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Conserved domains on  [gi|966959253|ref|XP_015001168|]
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anion exchange transporter isoform X2 [Macaca mulatta]

Protein Classification

SLC26A/SulP family transporter( domain architecture ID 1000281)

SLC26A/SulP family transporter may be an inorganic anion uptake transporter or an anion:anion exchange transporter, similar to human anion exchange transporter that acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport

Gene Ontology:  GO:0008509|GO:0015698
PubMed:  12759755|23506885
SCOP:  4006096
TCDB:  2.A.53

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK11660 super family cl46980
putative transporter; Provisional
33-636 8.39e-96

putative transporter; Provisional


The actual alignment was detected with superfamily member TIGR00815:

Pssm-ID: 481320 [Multi-domain]  Cd Length: 552  Bit Score: 305.41  E-value: 8.39e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253   33 PILDWAPHYNLKEnLLPDTVSGIMLAVQQVTQGLAFAVLSSVHPVFGLYGSLFPAIIYAIFGMGRHVATGTFALTSLISA 112
Cdd:TIGR00815   1 PVLRWLRKYRLKK-FKGDLMAGLTVGILLIPQAIAYAKLAGLPPIYGLYTSFVPPIIYALFGSSRHIAIGPTASVSLLLG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253  113 NAVERIvpqniqnlttpsntsvlGLSDFEMQRIHVAVAVSFLGGVIQVAMFVLQLGSATFVVTEPVISAMTTGAATHVVT 192
Cdd:TIGR00815  80 SLVQRE-----------------GLQGLFDDYIRLAFTATLLAGIFQVIMGLLRLGFLIEYLSHAVLVGFTAGAAITIGL 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253  193 SQVKYLLGMKMPYISGPLGFFY-IYAYVFENiksvRLEALLLSLLSIVVLVLVKELNEQFKRKIKVVLPVDLVLIIAASF 271
Cdd:TIGR00815 143 SQLKGLLGLSIFVKTDILGVVIsTWASLHQN----NWCTLVIGLLFLLFLLATKELGKRNKKLLWAPAPAPLLVVVLATL 218
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253  272 ACYCTNMENtYGLEVVGHIPQGIPS--PRAPPMNILSAVITEAFGVALVGYVASLALAQGSAKKFKYSIDDNQEFLAHGL 349
Cdd:TIGR00815 219 IVTIGLHDS-QGVSIVGHIPQGLSFfpPITFTWQHLPTLAPDAIAIAIVGLTESILTARVFAAMTGYEIDANKELVALGI 297
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253  350 SNIVSSFFFCIPSAAAMGRTAGLYSTGAKTQVACLISCIFVLIVIYAIGPLLYWLPMCVLASIIVVGLKGmLIQFRDLKK 429
Cdd:TIGR00815 298 ANIVGSFFSCYPATGSLSRTAVNYKAGCKTQLSAIVMAIVVLLVLLVLAPLFYYIPLAALAAIIISAAVG-LIDIRELYL 376
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253  430 YWNVDKIDWGIWVSTYVFTICFAANVGLLFGVVCTIAIVIGRFPRAMTLSIKNMKEMEF--KVKTEMDSETLQQVKIISI 507
Cdd:TIGR00815 377 LWKADKMDFVVWLGTFLGVVFTSIEIGLLVGVSLSAFFFILRVARPRAAVLGRIPGTEDyeNIEQYPKAQTPPGILIFRV 456
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253  508 NNPLVFLNAKKFYTDLMNIIqkenacnqplDDISKCEQntllnslsngncnevsqscpnekcSLILDCSGFTFFDYSGVS 587
Cdd:TIGR00815 457 DGPLYFANAEDLKERLLKWL----------ETLELDPQ------------------------IIILDMSAVPFLDTSGIH 502
                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|
gi 966959253  588 MLVEVYMDCKGRSVDVLLAHCTASLIKGMTYYGNLDS-EKPIFFESVSAA 636
Cdd:TIGR00815 503 ALEELFKELKARGIQLLLANPNPAVISTLARAGFVELiGEEHFFPSVHDA 552
 
Name Accession Description Interval E-value
sulP TIGR00815
high affinity sulphate transporter 1; The SulP family is a large and ubiquitous family with ...
33-636 8.39e-96

high affinity sulphate transporter 1; The SulP family is a large and ubiquitous family with over 30 sequenced members derived from bacteria, fungi, plants and animals. Many organisms including Bacillus subtilis, Synechocystis sp, Saccharomyces cerevisiae, Arabidopsis thaliana and Caenorhabditis elegans possess multiple SulP family paralogues. Many of these proteins are functionally characterized, and all are sulfate uptake transporters. Some transport their substrate with high affinities, while others transport it with relatively low affinities. Most function by SO42- :H+symport, but SO42- :HCO3- antiport has been reported for the rat protein (spP45380). The bacterial proteins vary in size from 434 residues to 566 residues with one exception, a Mycobacterium tuberculosis protein with 784 residues. The eukaryotic proteins vary in size from 611 residues to 893 residues with one exception, a protein designated "early nodulin 70 protein" from Glycine max which is reported to be of 485 residues. Thus, the eukaryotic proteins are almost without exception larger than the prokaryotic proteins. These proteins exhibit 10-13 putative transmembrane a-helical spanners (TMSs) depending on the protein. The phylogenetic tree for the SulP family reveals five principal branches. Three of these are bacterial specific as follows: one bears a single protein from M. tuberculosis; a second bears two proteins, one from M. tuberculosis, the other from Synechocystis sp, and the third bears all remaining prokaryotic proteins. The remaining two clusters bear only eukaryotic proteins with the animal proteins all localized to one branch and the plant and fungal proteins localized to the other. The generalized transport reactions catalyzed by SulP family proteins are: (1) SO42- (out) + nH+ (out) --> SO42- (in) + nH+ (in). (2) SO42- (out) + nHCO3- (in) SO42- (in) + nHCO3- (out). [Transport and binding proteins, Anions]


Pssm-ID: 273284 [Multi-domain]  Cd Length: 552  Bit Score: 305.41  E-value: 8.39e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253   33 PILDWAPHYNLKEnLLPDTVSGIMLAVQQVTQGLAFAVLSSVHPVFGLYGSLFPAIIYAIFGMGRHVATGTFALTSLISA 112
Cdd:TIGR00815   1 PVLRWLRKYRLKK-FKGDLMAGLTVGILLIPQAIAYAKLAGLPPIYGLYTSFVPPIIYALFGSSRHIAIGPTASVSLLLG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253  113 NAVERIvpqniqnlttpsntsvlGLSDFEMQRIHVAVAVSFLGGVIQVAMFVLQLGSATFVVTEPVISAMTTGAATHVVT 192
Cdd:TIGR00815  80 SLVQRE-----------------GLQGLFDDYIRLAFTATLLAGIFQVIMGLLRLGFLIEYLSHAVLVGFTAGAAITIGL 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253  193 SQVKYLLGMKMPYISGPLGFFY-IYAYVFENiksvRLEALLLSLLSIVVLVLVKELNEQFKRKIKVVLPVDLVLIIAASF 271
Cdd:TIGR00815 143 SQLKGLLGLSIFVKTDILGVVIsTWASLHQN----NWCTLVIGLLFLLFLLATKELGKRNKKLLWAPAPAPLLVVVLATL 218
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253  272 ACYCTNMENtYGLEVVGHIPQGIPS--PRAPPMNILSAVITEAFGVALVGYVASLALAQGSAKKFKYSIDDNQEFLAHGL 349
Cdd:TIGR00815 219 IVTIGLHDS-QGVSIVGHIPQGLSFfpPITFTWQHLPTLAPDAIAIAIVGLTESILTARVFAAMTGYEIDANKELVALGI 297
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253  350 SNIVSSFFFCIPSAAAMGRTAGLYSTGAKTQVACLISCIFVLIVIYAIGPLLYWLPMCVLASIIVVGLKGmLIQFRDLKK 429
Cdd:TIGR00815 298 ANIVGSFFSCYPATGSLSRTAVNYKAGCKTQLSAIVMAIVVLLVLLVLAPLFYYIPLAALAAIIISAAVG-LIDIRELYL 376
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253  430 YWNVDKIDWGIWVSTYVFTICFAANVGLLFGVVCTIAIVIGRFPRAMTLSIKNMKEMEF--KVKTEMDSETLQQVKIISI 507
Cdd:TIGR00815 377 LWKADKMDFVVWLGTFLGVVFTSIEIGLLVGVSLSAFFFILRVARPRAAVLGRIPGTEDyeNIEQYPKAQTPPGILIFRV 456
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253  508 NNPLVFLNAKKFYTDLMNIIqkenacnqplDDISKCEQntllnslsngncnevsqscpnekcSLILDCSGFTFFDYSGVS 587
Cdd:TIGR00815 457 DGPLYFANAEDLKERLLKWL----------ETLELDPQ------------------------IIILDMSAVPFLDTSGIH 502
                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|
gi 966959253  588 MLVEVYMDCKGRSVDVLLAHCTASLIKGMTYYGNLDS-EKPIFFESVSAA 636
Cdd:TIGR00815 503 ALEELFKELKARGIQLLLANPNPAVISTLARAGFVELiGEEHFFPSVHDA 552
Sulfate_transp pfam00916
Sulfate permease family; This family of integral membrane proteins are known as the Sulfate ...
47-444 5.56e-88

Sulfate permease family; This family of integral membrane proteins are known as the Sulfate Permease (SulP) family. SulP is a large family found in all domains of life. Although sulfate is a commonly transported ion there are many other activities in this family. See the TCDB description for a comprehensive summary.


Pssm-ID: 459995 [Multi-domain]  Cd Length: 379  Bit Score: 279.52  E-value: 5.56e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253   47 LLPDTVSGIMLAVQQVTQGLAFAVLSSVHPVFGLYGSLFPAIIYAIFGMGRHVATGTFALTSLISANAVERIVPQNIQNl 126
Cdd:pfam00916   1 LKGDLIAGITVAILAIPQALAYAILAGLPPIYGLYSSFVPGFVYALFGTSRHLAIGPVAVLSLMVGAAIAKLAAKDPEL- 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253  127 ttpsntsvlglsdfemqRIHVAVAVSFLGGVIQVAMFVLQLGSATFVVTEPVISAMTTGAATHVVTSQVKYLLGMkmPYI 206
Cdd:pfam00916  80 -----------------GIALAFTLTFLAGIIQLALGLLRLGFLVTFLSHAVISGFMGGAAIVILLSQLKVLLGL--TNF 140
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253  207 SGPLGFFYIYAYVFENIKSVRLEALLLSLLSIVVLVLVKELNEQFKRKIKVVLPVDLVLIIAASFACYCTNMENTYGLEV 286
Cdd:pfam00916 141 SGPGYVVSVLQSLFTNLDKVNLATLVLGLLVLVILLFTKELGKKYKKLFWIPAPAPLVAVVLATLVSAIFDLLRRYGVKI 220
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253  287 VGHIPQGIPSPRAPPM--NILSAVITEAFGVALVGYVASLALAQGSAKKFKYSIDDNQEFLAHGLSNIVSSFFFCIPSAA 364
Cdd:pfam00916 221 VGEIPSGLPPFSLPKFswSLLSALLPDALAIAIVGLLEAIAISKSFAKKKGYEVDSNQELVALGFANILSGLFGGYPATG 300
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253  365 AMGRTAGLYSTGAKTQVACLISCIFVLIVIYAIGPLLYWLPMCVLASIIVVGLKGmLIQFRDLKKYWNVDKIDWGIWVST 444
Cdd:pfam00916 301 AFSRSAVNIKAGAKTPLSGIIMAVIVLLVLLFLTPLFAYIPKAVLAAIIIVAGKG-LIDYRELKHLWRLSKLDFLIWLAT 379
SUL1 COG0659
Sulfate permease or related transporter, MFS superfamily [Inorganic ion transport and ...
40-642 1.05e-76

Sulfate permease or related transporter, MFS superfamily [Inorganic ion transport and metabolism];


Pssm-ID: 440424 [Multi-domain]  Cd Length: 529  Bit Score: 254.65  E-value: 1.05e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253  40 HYNlKENLLPDTVSGIMLAVQQVTQGLAFAVLSSVHPVFGLYGSLFPAIIYAIFGMGRHVATGTFALTSLISANAVEriv 119
Cdd:COG0659    1 GYR-RSNLRGDLLAGLTVALVALPLALAFAIAAGLPPEAGLYAAIVGGIVYALFGGSRLLISGPTAALAVVVAAAVA--- 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253 120 pqniqnlttpsntsvlglsdfEMQRIHVAVAVSFLGGVIQVAMFVLQLGSATFVVTEPVISAMTTGAATHVVTSQVKYLL 199
Cdd:COG0659   77 ---------------------PLGSLALLLAATLLAGVLQLLLGLLRLGRLARFIPRPVIVGFLAGIAILIILGQLPHLL 135
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253 200 GMKMPyisgPLGFFYIYAYVFENIKSVRLEALLLSLLSIVVLVlvkelneqFKRKIKVVLPVDLVLIIAASFACYCTNME 279
Cdd:COG0659  136 GLPAP----GGSFLEKLAALLAALGEINPPTLALGLLTLAILL--------LLPRLLKRIPGPLVAVVLGTLLVWLLGLD 203
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253 280 ntygLEVVGHIPQGIPSPRAPPMNI--LSAVITEAFGVALVGYVASLALAQGSAKKFKYSIDDNQEFLAHGLSNIVSSFF 357
Cdd:COG0659  204 ----VATVGEIPSGLPSFSLPDFSLetLRALLPPALTIALVGSIESLLTARAVDAMTGTRSDPNRELIAQGLANIASGLF 279
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253 358 FCIPSAAAMGRTAGLYSTGAKTQVACLISCIFVLIVIYAIGPLLYWLPMCVLASI-IVVGLKgmLIQFRDLKKYWNVDKI 436
Cdd:COG0659  280 GGLPVTGSISRSAVNVKAGARTRLSGIVHALFLLLVLLFLAPLLAYIPLAALAAIlIVVGIG--LIDWRSFRRLWRAPRS 357
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253 437 DWGIWVSTYVFTICFAANVGLLFGVVCTIAIVIGRFPRAMTLSIKNMKEMEFKVKTEMDSETLQQVKIISINNPLVFLNA 516
Cdd:COG0659  358 DFLVMLVTFLVTVFTDLLIGVLVGVLLSLLLFLRRVSRPHVVVLRVPGTHFRNVERHPEAETGPGVLVYRLDGPLFFGNA 437
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253 517 KKFYTDLMNIiqkenacNQPLDDIskceqntllnslsngncnevsqscpnekcslILDCSGFTFFDYSGVSMLVEVYMDC 596
Cdd:COG0659  438 ERLKERLDAL-------APDPRVV-------------------------------ILDLSAVPFIDATALEALEELAERL 479
                        570       580       590       600
                 ....*....|....*....|....*....|....*....|....*..
gi 966959253 597 KGRSVDVLLAHCTASLIKGMTYYGNLDSEKPI-FFESVSAAISHIHS 642
Cdd:COG0659  480 RARGITLELAGLKPPVRDLLERAGLLDELGEErVFPDLDEALEAAEE 526
PRK11660 PRK11660
putative transporter; Provisional
37-528 1.52e-23

putative transporter; Provisional


Pssm-ID: 183265 [Multi-domain]  Cd Length: 568  Bit Score: 105.03  E-value: 1.52e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253  37 WAPHYNLKEnLLPDTVSGIMLAVQQVTQGLAFAVLSSVHPVFGLYGSLFPAIIYAIFGMGRHVATG-TFALTSLISAnav 115
Cdd:PRK11660  20 WKEKYTAAR-FTRDLIAGITVGIIAIPLAMALAIASGVPPQYGLYTAAVAGIVIALTGGSRFSVSGpTAAFVVILYP--- 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253 116 erIVPQniqnlttpsntsvLGLSDFEMqrihvavaVSFLGGVIQVAMFVLQLGSATFVVTEPVISAMTTGAATHVVTSQV 195
Cdd:PRK11660  96 --VSQQ-------------FGLAGLLV--------ATLMSGIILILMGLARLGRLIEYIPLSVTLGFTSGIGIVIATLQI 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253 196 KYLLGMKMPyiSGPLGFFYIYAYVFENIKSVRLEALLLSLLSIVVLVlvkelneqFKRKIKVVLPVDLVLIIAASFACYc 275
Cdd:PRK11660 153 KDFFGLQMA--HVPEHYLEKVGALFQALPTINWGDALIGIVTLGVLI--------LWPRLKIRLPGHLPALLAGTAVMG- 221
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253 276 tnMENTYGLEVV------------GHIPQGIPS-------------PRAPPMNI----LSAVITEAFGVALVGYVASLAL 326
Cdd:PRK11660 222 --VLNLLGGHVAtigsrfhyvladGSQGNGIPPllpqfvlpwnlpgADGQPFTLswdlIRALLPAAFSMAMLGAIESLLC 299
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253 327 A---QG-SAKKFkysiDDNQEFLAHGLSNIVSSFFFCIPSAAAMGRTAGLYSTGAKTQVACLISCIFVLIVIYAIGPLLY 402
Cdd:PRK11660 300 AvvlDGmTGTKH----SANSELVGQGLGNIVAPFFGGITATAAIARSAANVRAGATSPISAVIHALLVLLALLVLAPLLS 375
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253 403 WLPMCVLASIIVVGLKGM--LIQFRDLKKYWNVDKIdwgiwvstYVFTICFAANVglLFGVVctIAIVIGRFPRAMtLSI 480
Cdd:PRK11660 376 YLPLSAMAALLLMVAWNMseAHKVVDLLRHAPKDDI--------IVMLLCMSLTV--LFDMV--IAISVGIVLASL-LFM 442
                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*...
gi 966959253 481 KNMKEMEfKVKTEMDSETLQQVKIISINNPLVFLNAKKFYTDLMNIIQ 528
Cdd:PRK11660 443 RRIAEMT-RLAPISVQDVPDDVLVLRINGPLFFAAAERLFTELESRTE 489
STAS_SulP_like_sulfate_transporter cd07042
Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, ...
495-630 6.38e-11

Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; The SulP family is a large and diverse family of anion transporters, with members from eubacteria, plants, fungi, and mammals. They contain 10 to 14 transmembrane helices which form the catalytic core of the protein and a C-terminal extension, the STAS (Sulphate Transporter and AntiSigma factor antagonist) domain which plays a role in the function and regulation of the transport activity. The STAS domain is found in the C-terminal region of sulphate transporters and bacterial anti-sigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


Pssm-ID: 132913 [Multi-domain]  Cd Length: 107  Bit Score: 59.56  E-value: 6.38e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253 495 DSETLQQVKIISINNPLVFLNAKKFYTDLMNIIQKEnacnqplddiskceqntllnslsngncnevsqscPNEKCsLILD 574
Cdd:cd07042    3 LAEEPPGVLIYRIDGPLFFGNAEYFKDRLLRLVDED----------------------------------PPLKV-VILD 47
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 966959253 575 CSGFTFFDYSGVSMLVEVYMDCKGRSVDVLLAHCTASLIKGMTYYGNLDSEKPIFF 630
Cdd:cd07042   48 LSAVNFIDSTAAEALEELVKDLRKRGVELYLAGLNPQVRELLERAGLLDEIGEENF 103
 
Name Accession Description Interval E-value
sulP TIGR00815
high affinity sulphate transporter 1; The SulP family is a large and ubiquitous family with ...
33-636 8.39e-96

high affinity sulphate transporter 1; The SulP family is a large and ubiquitous family with over 30 sequenced members derived from bacteria, fungi, plants and animals. Many organisms including Bacillus subtilis, Synechocystis sp, Saccharomyces cerevisiae, Arabidopsis thaliana and Caenorhabditis elegans possess multiple SulP family paralogues. Many of these proteins are functionally characterized, and all are sulfate uptake transporters. Some transport their substrate with high affinities, while others transport it with relatively low affinities. Most function by SO42- :H+symport, but SO42- :HCO3- antiport has been reported for the rat protein (spP45380). The bacterial proteins vary in size from 434 residues to 566 residues with one exception, a Mycobacterium tuberculosis protein with 784 residues. The eukaryotic proteins vary in size from 611 residues to 893 residues with one exception, a protein designated "early nodulin 70 protein" from Glycine max which is reported to be of 485 residues. Thus, the eukaryotic proteins are almost without exception larger than the prokaryotic proteins. These proteins exhibit 10-13 putative transmembrane a-helical spanners (TMSs) depending on the protein. The phylogenetic tree for the SulP family reveals five principal branches. Three of these are bacterial specific as follows: one bears a single protein from M. tuberculosis; a second bears two proteins, one from M. tuberculosis, the other from Synechocystis sp, and the third bears all remaining prokaryotic proteins. The remaining two clusters bear only eukaryotic proteins with the animal proteins all localized to one branch and the plant and fungal proteins localized to the other. The generalized transport reactions catalyzed by SulP family proteins are: (1) SO42- (out) + nH+ (out) --> SO42- (in) + nH+ (in). (2) SO42- (out) + nHCO3- (in) SO42- (in) + nHCO3- (out). [Transport and binding proteins, Anions]


Pssm-ID: 273284 [Multi-domain]  Cd Length: 552  Bit Score: 305.41  E-value: 8.39e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253   33 PILDWAPHYNLKEnLLPDTVSGIMLAVQQVTQGLAFAVLSSVHPVFGLYGSLFPAIIYAIFGMGRHVATGTFALTSLISA 112
Cdd:TIGR00815   1 PVLRWLRKYRLKK-FKGDLMAGLTVGILLIPQAIAYAKLAGLPPIYGLYTSFVPPIIYALFGSSRHIAIGPTASVSLLLG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253  113 NAVERIvpqniqnlttpsntsvlGLSDFEMQRIHVAVAVSFLGGVIQVAMFVLQLGSATFVVTEPVISAMTTGAATHVVT 192
Cdd:TIGR00815  80 SLVQRE-----------------GLQGLFDDYIRLAFTATLLAGIFQVIMGLLRLGFLIEYLSHAVLVGFTAGAAITIGL 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253  193 SQVKYLLGMKMPYISGPLGFFY-IYAYVFENiksvRLEALLLSLLSIVVLVLVKELNEQFKRKIKVVLPVDLVLIIAASF 271
Cdd:TIGR00815 143 SQLKGLLGLSIFVKTDILGVVIsTWASLHQN----NWCTLVIGLLFLLFLLATKELGKRNKKLLWAPAPAPLLVVVLATL 218
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253  272 ACYCTNMENtYGLEVVGHIPQGIPS--PRAPPMNILSAVITEAFGVALVGYVASLALAQGSAKKFKYSIDDNQEFLAHGL 349
Cdd:TIGR00815 219 IVTIGLHDS-QGVSIVGHIPQGLSFfpPITFTWQHLPTLAPDAIAIAIVGLTESILTARVFAAMTGYEIDANKELVALGI 297
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253  350 SNIVSSFFFCIPSAAAMGRTAGLYSTGAKTQVACLISCIFVLIVIYAIGPLLYWLPMCVLASIIVVGLKGmLIQFRDLKK 429
Cdd:TIGR00815 298 ANIVGSFFSCYPATGSLSRTAVNYKAGCKTQLSAIVMAIVVLLVLLVLAPLFYYIPLAALAAIIISAAVG-LIDIRELYL 376
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253  430 YWNVDKIDWGIWVSTYVFTICFAANVGLLFGVVCTIAIVIGRFPRAMTLSIKNMKEMEF--KVKTEMDSETLQQVKIISI 507
Cdd:TIGR00815 377 LWKADKMDFVVWLGTFLGVVFTSIEIGLLVGVSLSAFFFILRVARPRAAVLGRIPGTEDyeNIEQYPKAQTPPGILIFRV 456
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253  508 NNPLVFLNAKKFYTDLMNIIqkenacnqplDDISKCEQntllnslsngncnevsqscpnekcSLILDCSGFTFFDYSGVS 587
Cdd:TIGR00815 457 DGPLYFANAEDLKERLLKWL----------ETLELDPQ------------------------IIILDMSAVPFLDTSGIH 502
                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|
gi 966959253  588 MLVEVYMDCKGRSVDVLLAHCTASLIKGMTYYGNLDS-EKPIFFESVSAA 636
Cdd:TIGR00815 503 ALEELFKELKARGIQLLLANPNPAVISTLARAGFVELiGEEHFFPSVHDA 552
Sulfate_transp pfam00916
Sulfate permease family; This family of integral membrane proteins are known as the Sulfate ...
47-444 5.56e-88

Sulfate permease family; This family of integral membrane proteins are known as the Sulfate Permease (SulP) family. SulP is a large family found in all domains of life. Although sulfate is a commonly transported ion there are many other activities in this family. See the TCDB description for a comprehensive summary.


Pssm-ID: 459995 [Multi-domain]  Cd Length: 379  Bit Score: 279.52  E-value: 5.56e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253   47 LLPDTVSGIMLAVQQVTQGLAFAVLSSVHPVFGLYGSLFPAIIYAIFGMGRHVATGTFALTSLISANAVERIVPQNIQNl 126
Cdd:pfam00916   1 LKGDLIAGITVAILAIPQALAYAILAGLPPIYGLYSSFVPGFVYALFGTSRHLAIGPVAVLSLMVGAAIAKLAAKDPEL- 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253  127 ttpsntsvlglsdfemqRIHVAVAVSFLGGVIQVAMFVLQLGSATFVVTEPVISAMTTGAATHVVTSQVKYLLGMkmPYI 206
Cdd:pfam00916  80 -----------------GIALAFTLTFLAGIIQLALGLLRLGFLVTFLSHAVISGFMGGAAIVILLSQLKVLLGL--TNF 140
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253  207 SGPLGFFYIYAYVFENIKSVRLEALLLSLLSIVVLVLVKELNEQFKRKIKVVLPVDLVLIIAASFACYCTNMENTYGLEV 286
Cdd:pfam00916 141 SGPGYVVSVLQSLFTNLDKVNLATLVLGLLVLVILLFTKELGKKYKKLFWIPAPAPLVAVVLATLVSAIFDLLRRYGVKI 220
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253  287 VGHIPQGIPSPRAPPM--NILSAVITEAFGVALVGYVASLALAQGSAKKFKYSIDDNQEFLAHGLSNIVSSFFFCIPSAA 364
Cdd:pfam00916 221 VGEIPSGLPPFSLPKFswSLLSALLPDALAIAIVGLLEAIAISKSFAKKKGYEVDSNQELVALGFANILSGLFGGYPATG 300
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253  365 AMGRTAGLYSTGAKTQVACLISCIFVLIVIYAIGPLLYWLPMCVLASIIVVGLKGmLIQFRDLKKYWNVDKIDWGIWVST 444
Cdd:pfam00916 301 AFSRSAVNIKAGAKTPLSGIIMAVIVLLVLLFLTPLFAYIPKAVLAAIIIVAGKG-LIDYRELKHLWRLSKLDFLIWLAT 379
SUL1 COG0659
Sulfate permease or related transporter, MFS superfamily [Inorganic ion transport and ...
40-642 1.05e-76

Sulfate permease or related transporter, MFS superfamily [Inorganic ion transport and metabolism];


Pssm-ID: 440424 [Multi-domain]  Cd Length: 529  Bit Score: 254.65  E-value: 1.05e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253  40 HYNlKENLLPDTVSGIMLAVQQVTQGLAFAVLSSVHPVFGLYGSLFPAIIYAIFGMGRHVATGTFALTSLISANAVEriv 119
Cdd:COG0659    1 GYR-RSNLRGDLLAGLTVALVALPLALAFAIAAGLPPEAGLYAAIVGGIVYALFGGSRLLISGPTAALAVVVAAAVA--- 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253 120 pqniqnlttpsntsvlglsdfEMQRIHVAVAVSFLGGVIQVAMFVLQLGSATFVVTEPVISAMTTGAATHVVTSQVKYLL 199
Cdd:COG0659   77 ---------------------PLGSLALLLAATLLAGVLQLLLGLLRLGRLARFIPRPVIVGFLAGIAILIILGQLPHLL 135
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253 200 GMKMPyisgPLGFFYIYAYVFENIKSVRLEALLLSLLSIVVLVlvkelneqFKRKIKVVLPVDLVLIIAASFACYCTNME 279
Cdd:COG0659  136 GLPAP----GGSFLEKLAALLAALGEINPPTLALGLLTLAILL--------LLPRLLKRIPGPLVAVVLGTLLVWLLGLD 203
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253 280 ntygLEVVGHIPQGIPSPRAPPMNI--LSAVITEAFGVALVGYVASLALAQGSAKKFKYSIDDNQEFLAHGLSNIVSSFF 357
Cdd:COG0659  204 ----VATVGEIPSGLPSFSLPDFSLetLRALLPPALTIALVGSIESLLTARAVDAMTGTRSDPNRELIAQGLANIASGLF 279
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253 358 FCIPSAAAMGRTAGLYSTGAKTQVACLISCIFVLIVIYAIGPLLYWLPMCVLASI-IVVGLKgmLIQFRDLKKYWNVDKI 436
Cdd:COG0659  280 GGLPVTGSISRSAVNVKAGARTRLSGIVHALFLLLVLLFLAPLLAYIPLAALAAIlIVVGIG--LIDWRSFRRLWRAPRS 357
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253 437 DWGIWVSTYVFTICFAANVGLLFGVVCTIAIVIGRFPRAMTLSIKNMKEMEFKVKTEMDSETLQQVKIISINNPLVFLNA 516
Cdd:COG0659  358 DFLVMLVTFLVTVFTDLLIGVLVGVLLSLLLFLRRVSRPHVVVLRVPGTHFRNVERHPEAETGPGVLVYRLDGPLFFGNA 437
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253 517 KKFYTDLMNIiqkenacNQPLDDIskceqntllnslsngncnevsqscpnekcslILDCSGFTFFDYSGVSMLVEVYMDC 596
Cdd:COG0659  438 ERLKERLDAL-------APDPRVV-------------------------------ILDLSAVPFIDATALEALEELAERL 479
                        570       580       590       600
                 ....*....|....*....|....*....|....*....|....*..
gi 966959253 597 KGRSVDVLLAHCTASLIKGMTYYGNLDSEKPI-FFESVSAAISHIHS 642
Cdd:COG0659  480 RARGITLELAGLKPPVRDLLERAGLLDELGEErVFPDLDEALEAAEE 526
PRK11660 PRK11660
putative transporter; Provisional
37-528 1.52e-23

putative transporter; Provisional


Pssm-ID: 183265 [Multi-domain]  Cd Length: 568  Bit Score: 105.03  E-value: 1.52e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253  37 WAPHYNLKEnLLPDTVSGIMLAVQQVTQGLAFAVLSSVHPVFGLYGSLFPAIIYAIFGMGRHVATG-TFALTSLISAnav 115
Cdd:PRK11660  20 WKEKYTAAR-FTRDLIAGITVGIIAIPLAMALAIASGVPPQYGLYTAAVAGIVIALTGGSRFSVSGpTAAFVVILYP--- 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253 116 erIVPQniqnlttpsntsvLGLSDFEMqrihvavaVSFLGGVIQVAMFVLQLGSATFVVTEPVISAMTTGAATHVVTSQV 195
Cdd:PRK11660  96 --VSQQ-------------FGLAGLLV--------ATLMSGIILILMGLARLGRLIEYIPLSVTLGFTSGIGIVIATLQI 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253 196 KYLLGMKMPyiSGPLGFFYIYAYVFENIKSVRLEALLLSLLSIVVLVlvkelneqFKRKIKVVLPVDLVLIIAASFACYc 275
Cdd:PRK11660 153 KDFFGLQMA--HVPEHYLEKVGALFQALPTINWGDALIGIVTLGVLI--------LWPRLKIRLPGHLPALLAGTAVMG- 221
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253 276 tnMENTYGLEVV------------GHIPQGIPS-------------PRAPPMNI----LSAVITEAFGVALVGYVASLAL 326
Cdd:PRK11660 222 --VLNLLGGHVAtigsrfhyvladGSQGNGIPPllpqfvlpwnlpgADGQPFTLswdlIRALLPAAFSMAMLGAIESLLC 299
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253 327 A---QG-SAKKFkysiDDNQEFLAHGLSNIVSSFFFCIPSAAAMGRTAGLYSTGAKTQVACLISCIFVLIVIYAIGPLLY 402
Cdd:PRK11660 300 AvvlDGmTGTKH----SANSELVGQGLGNIVAPFFGGITATAAIARSAANVRAGATSPISAVIHALLVLLALLVLAPLLS 375
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253 403 WLPMCVLASIIVVGLKGM--LIQFRDLKKYWNVDKIdwgiwvstYVFTICFAANVglLFGVVctIAIVIGRFPRAMtLSI 480
Cdd:PRK11660 376 YLPLSAMAALLLMVAWNMseAHKVVDLLRHAPKDDI--------IVMLLCMSLTV--LFDMV--IAISVGIVLASL-LFM 442
                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*...
gi 966959253 481 KNMKEMEfKVKTEMDSETLQQVKIISINNPLVFLNAKKFYTDLMNIIQ 528
Cdd:PRK11660 443 RRIAEMT-RLAPISVQDVPDDVLVLRINGPLFFAAAERLFTELESRTE 489
STAS_SulP_like_sulfate_transporter cd07042
Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, ...
495-630 6.38e-11

Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; The SulP family is a large and diverse family of anion transporters, with members from eubacteria, plants, fungi, and mammals. They contain 10 to 14 transmembrane helices which form the catalytic core of the protein and a C-terminal extension, the STAS (Sulphate Transporter and AntiSigma factor antagonist) domain which plays a role in the function and regulation of the transport activity. The STAS domain is found in the C-terminal region of sulphate transporters and bacterial anti-sigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


Pssm-ID: 132913 [Multi-domain]  Cd Length: 107  Bit Score: 59.56  E-value: 6.38e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253 495 DSETLQQVKIISINNPLVFLNAKKFYTDLMNIIQKEnacnqplddiskceqntllnslsngncnevsqscPNEKCsLILD 574
Cdd:cd07042    3 LAEEPPGVLIYRIDGPLFFGNAEYFKDRLLRLVDED----------------------------------PPLKV-VILD 47
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 966959253 575 CSGFTFFDYSGVSMLVEVYMDCKGRSVDVLLAHCTASLIKGMTYYGNLDSEKPIFF 630
Cdd:cd07042   48 LSAVNFIDSTAAEALEELVKDLRKRGVELYLAGLNPQVRELLERAGLLDEIGEENF 103
STAS pfam01740
STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is ...
494-636 1.40e-07

STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is found in the C terminal region of Sulphate transporters and bacterial antisigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


Pssm-ID: 426404 [Multi-domain]  Cd Length: 106  Bit Score: 49.92  E-value: 1.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253  494 MDSETLQQVKIISINNPLVFLNAKKFYTDLMNIIQKENACNqplddiskceqntllnslsngncnevsqscpnekcsLIL 573
Cdd:pfam01740   2 PEAEEIPGILILRLDGPLDFANAESLRERLLRALEEGEIKH------------------------------------VVL 45
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966959253  574 DCSGFTFFDYSGVSMLVEVYMDCKGRSVDVLLAHCTASLIKGMTYYGNLDSEKpiFFESVSAA 636
Cdd:pfam01740  46 DLSAVPFIDSSGLGALEELYKELRRRGVELVLVGPSPEVARTLEKTGLDDIIK--IFPTVAEA 106
CodB COG1457
Purine-cytosine permease or related protein [Nucleotide transport and metabolism];
51-184 4.62e-03

Purine-cytosine permease or related protein [Nucleotide transport and metabolism];


Pssm-ID: 441066 [Multi-domain]  Cd Length: 448  Bit Score: 39.85  E-value: 4.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966959253  51 TVSGIMLAVQQVTQGLAFAVLSsvHPVFGLYGSLFPAIIYAIFGMgrhvatGTFALTSLISANAVERIVPQniqnLTTPS 130
Cdd:COG1457   75 FLLGALIAYIGARTGLPTMLLS--RAAFGYRGSTLPSLLNALTTI------GWFAVEAAIAAQALAALLGG----LGIPL 142
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966959253 131 NTSVL--GLsdfemqrIHVAVAV------SFLGGVIQVAMFVLQLGSATFVVTEPVISAMTT 184
Cdd:COG1457  143 VLAYLivGL-------LVILLAIfgyraiSRLQRWAVPLLLVLFVLLVVLALSHPGLSALLA 197
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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