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Conserved domains on  [gi|966958624|ref|XP_015000891|]
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brefeldin A-inhibited guanine nucleotide-exchange protein 1 isoform X3 [Macaca mulatta]

Protein Classification

ARF family guanine-nucleotide exchange factor( domain architecture ID 1001583)

ARF family guanine-nucleotide exchange factor activates ARF proteins by exchanging bound GDP for free GTP

Gene Ontology:  GO:0032012|GO:0015031
PubMed:  11752622

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PLN03076 super family cl33628
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
 15-1760 0e+00

ARF guanine nucleotide exchange factor (ARF-GEF); Provisional


The actual alignment was detected with superfamily member PLN03076:

Pssm-ID: 215560 [Multi-domain]  Cd Length: 1780  Bit Score: 1012.05  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624   15 ALEKILADKEVKKahHSQLRKACEVALEEIKAETEKQSPP--HGEAKAGSSTLP-PVKSKT----NFIEADKYFLPFELA 87
Cdd:PLN03076   17 ALEKIIKNASWRK--HSKLAHECKAVIERLNSPEKNPPSTssAAADSASASSLPgPLHDGGsieySLAESELILSPLINA 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624   88 CQSKCPRIVSTSLDCLQKLIAYGHLTGNAPDSTTPGKKLIDRIIETICGCFQgpQTDEGVQLQIIKALLTAVTSQHIEIH 167
Cdd:PLN03076   95 CGTGSAKIVDPALDCIQKLIAHGYLRGEADPSGGPEALLLAKLIESVCKCHD--LGDEGIELLVLKTLLSAVTSTSLRIH 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624  168 EGTVLQAVRTCYNIYLASKNLINQTTAKATLTQMLNVIFARMEN-------QALQEAKQMEK-ERhrqqqhllqSPVSHH 239
Cdd:PLN03076  173 GDCLLQAVRTCYDIYLGSKNVVNQTTAKASLIQMLVIVFRRMEAdsstvpiQPIVVAELMEPaEK---------SDSDTS 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624  240 EPESPQlrylppQTVDHISQeherdldlhtnDVDKSLQddtePENGSDISSAENEQTEADQATAAETLSKNDMLYDGENH 319
Cdd:PLN03076  244 MTQFVQ------GFITKIMQ-----------DIDGVLN----PATAGKSSGSGAHDGAFETTATVETTNPADLLDSTDKD 302

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624  320 DCEEKPQDIvqniveEMVnivvgdmgeRTAInasaDGNIGTIEDGSDSEniqangipgtpisvaytpslpDDRLSVSSND 399
Cdd:PLN03076  303 MLDAKYWEI------SMY---------KSAL----EGRKGELADGEVEK---------------------DDDLEVQIGN 342

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624  400 TqesgnssgpspgakfshiLQKDAFLVFRSLCKLSMK-PLSDGPPDPKSheLRSKILSLQLLLSILQNAGPVFRTNEMFI 478
Cdd:PLN03076  343 K------------------LRRDAFLVFRALCKLSMKtPPKEALADPQL--MRGKILALELLKILLENAGAVFRTSDRFL 402

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624  479 NAIKQYLCVALSKNGVSSVPEVFELSLSIFLTLLSNFKTHLKMQIEVFFKEIFLYILET-STSSFDHKWMVIQTLTRICA 557
Cdd:PLN03076  403 GAIKQYLCLSLLKNSASSLMIIFQLSCSIFISLVSRFRAGLKAEIGVFFPMIVLRVLENvAQPNFQQKMIVLRFLDKLCV 482

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624  558 DAQSVVDIYVNYDCDLNAANIFERLVNDLSKIAQG-RGSQELGMSNVQELSLRKKGLECLVSILKCMVEWSKDQYVNPNS 636
Cdd:PLN03076  483 DSQILVDIFINYDCDVNSSNIFERMVNGLLKTAQGvPPGVETTLLPPQEAAMKLEAMKCLVAILRSMGDWMNKQLRLPDP 562

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624  637 QTTlgqEKPSEQEMS-EIKHPETINRYGSLNSLESTSssgigsYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKPKR 715
Cdd:PLN03076  563 ASL---KKLDAVENNlEPGSLPVANGNGDENGEGSDS------HSELSSETSDAATIEQRRAYKLELQEGISLFNRKPKK 633

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624  716 GIQYLQEQGMLGTTPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRMFLEGFRLPGEAQ 795
Cdd:PLN03076  634 GIEFLINANKVGESPEEIAAFLKDASGLNKTLIGDYLGEREDLSLKVMHAYVDSFDFQGMEFDEAIRAFLQGFRLPGEAQ 713

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624  796 KIDRLMEKFAARYLECNqgQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSAIYN 875
Cdd:PLN03076  714 KIDRIMEKFAERYCKCN--PKAFSSADTAYVLAYSVIMLNTDAHNPMVKNKMSADDFIRNNRGIDDGKDLPEEFMRSLYE 791

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624  876 EIAGKKISMKEtkELTIPTKssKQNVASEKQRRLLYNLEMEQMAKTAKALMEA----VSHVQAPFT-----------SAT 940
Cdd:PLN03076  792 RISKNEIKMKE--DDLVPQQ--KQSANSNRILGLDSILNIVIRKRGEDSYMETsddlIKHMQEQFKekarksesvyyAAT 867

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624  941 HLEHVRPMFKLAWTPFLAAFSVGLQDCDDTEVASLCLEGIRCAIRIACIFSIQLERDAYVQALARFTLLTVSSGItemKQ 1020
Cdd:PLN03076  868 DVVILRFMVEVCWAPMLAAFSVPLDQSDDEVVTFQCLEGFRHAIHVTAVMSMKTHRDAFVTSLAKFTSLHSPADI---KQ 944

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624 1021 KNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQLIGTGVKP---------------RYISGTV--------RGR- 1076
Cdd:PLN03076  945 KNIDAIKAIVSIADEDGNYLQEAWEHILTCVSRFEHLHLLGEGAPPdatffaapqnesdksKQAKSPIlpvlkrkgPGKl 1024

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624 1077 ----EGSLTGTKDQAPdefVGlGLVGGNVDWKQIASIQESIGETsSQSVVVAVDRIFTGSTRLDGNAIVDFVRWLCAVSM 1152
Cdd:PLN03076 1025 qyaaAAVRRGSYDSAG---VG-GKASGVVTSEQMNNLVSNLNML-EQVGSFEMNRIFTRSQKLNSEAIIDFVKALCKVSM 1099

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624 1153 DELLSTTHPRMFSLQKIVEISYYNMGRIRLQWSRIWEVIGDHFNKVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRF 1232
Cdd:PLN03076 1100 EELRSPSDPRVFSLTKIVEIAHYNMNRIRLVWSSIWHVLSDFFVTIGCSENLSIAIFAMDSLRQLSMKFLEREELANYNF 1179

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624 1233 QKDFLRPFEHIMKRNRSPTIRDMVVRCIAQMVNSQAANIRSGWKNIFSVFHLAASDQDESIVELAFQTTGHIVtlvfEKH 1312
Cdd:PLN03076 1180 QNEFMKPFVIVMRKSNAVEIRELIIRCVSQMVLSRVNNVKSGWKSMFMVFTTAAYDDHKNIVLLAFEIIEKII----REY 1255

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624 1313 FPATID----SFQDAVKCLSEFACNAAFPDTSMEAIRLIRHCAKYVSDRPQAFKEYTSDDMNVAPEDRVWVRG------- 1381
Cdd:PLN03076 1256 FPYITEtettTFTDCVNCLIAFTNSRFNKDISLNAIAFLRFCATKLAEGDLGSSSRNKDKEAPPSSPQSGKDGkqesgef 1335

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624 1382 ---------WFPILFELSCIINRCKLDVRTRGLTVMFEIMKTYGHTYEKHWWQDLFRIV-FRIFDNMK---------LPE 1442
Cdd:PLN03076 1336 tdkddhlyfWFPLLAGLSELSFDPRPEIRKSALQVLFDTLRNHGHLFSLPLWERVFESVlFPIFDYVRhaidpsggdEPE 1415

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624 1443 QQTEKAE--------WMTTTCNHALYAICDVFTQYLEVLsDVLLDDIFAQLYWCVQQDNEQLARSGTNCLENVVILNGEK 1514
Cdd:PLN03076 1416 GQGVDGDqgeldqdaWLYETCTLALQLVVDLFVKFYPTV-NPLLKKVLMLLVSFIKRPHQSLAGIGIAAFVRLMSNAGHL 1494

                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624 1515 FTLEIWDKTCNCTLDIFKTTIPHAlltwrptsgetappppspDTISQKSVDIHDSVQPRSVDNRPQAPLVSASAVNEevs 1594
Cdd:PLN03076 1495 FSDEKWLEVVLSLKEAANATLPDF------------------SYVVSGEYMPAENIQDSENAEAASSSTADNDAEAE--- 1553

                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624 1595 kikstakfPEQKLFAALL-IKC--VVQLELIQTIDNIVffpatskkedaenlaaaqrdavdfdvrvdtqdqGMYR-FLTS 1670
Cdd:PLN03076 1554 --------RSRRLYAAISdAKCraAVQLLLIQAVMEIY---------------------------------NMYRpRLSA 1592

                        1770      1780      1790      1800      1810      1820      1830      1840
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624 1671 QQLFKLLDCLLESHRFAKAFNSNNEQRTALWKAGFKGKSK-PNLLKQETSSLACGLRILFRMYMDESRVSAWEEVQQRLL 1749
Cdd:PLN03076 1593 KNTLVLFDALHTVASHAHKINSDTALRSKLQELGSMTQMQdPPLLRLENESYQICLTFLQNLILDKPPLAKEAEVESRLV 1672

                        1850
                  ....*....|.
gi 966958624 1750 NVCSEALSYFL 1760
Cdd:PLN03076 1673 ELCEEVLQFYI 1683
 
Name Accession Description Interval E-value
PLN03076 PLN03076
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
 15-1760 0e+00

ARF guanine nucleotide exchange factor (ARF-GEF); Provisional


Pssm-ID: 215560 [Multi-domain]  Cd Length: 1780  Bit Score: 1012.05  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624   15 ALEKILADKEVKKahHSQLRKACEVALEEIKAETEKQSPP--HGEAKAGSSTLP-PVKSKT----NFIEADKYFLPFELA 87
Cdd:PLN03076   17 ALEKIIKNASWRK--HSKLAHECKAVIERLNSPEKNPPSTssAAADSASASSLPgPLHDGGsieySLAESELILSPLINA 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624   88 CQSKCPRIVSTSLDCLQKLIAYGHLTGNAPDSTTPGKKLIDRIIETICGCFQgpQTDEGVQLQIIKALLTAVTSQHIEIH 167
Cdd:PLN03076   95 CGTGSAKIVDPALDCIQKLIAHGYLRGEADPSGGPEALLLAKLIESVCKCHD--LGDEGIELLVLKTLLSAVTSTSLRIH 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624  168 EGTVLQAVRTCYNIYLASKNLINQTTAKATLTQMLNVIFARMEN-------QALQEAKQMEK-ERhrqqqhllqSPVSHH 239
Cdd:PLN03076  173 GDCLLQAVRTCYDIYLGSKNVVNQTTAKASLIQMLVIVFRRMEAdsstvpiQPIVVAELMEPaEK---------SDSDTS 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624  240 EPESPQlrylppQTVDHISQeherdldlhtnDVDKSLQddtePENGSDISSAENEQTEADQATAAETLSKNDMLYDGENH 319
Cdd:PLN03076  244 MTQFVQ------GFITKIMQ-----------DIDGVLN----PATAGKSSGSGAHDGAFETTATVETTNPADLLDSTDKD 302

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624  320 DCEEKPQDIvqniveEMVnivvgdmgeRTAInasaDGNIGTIEDGSDSEniqangipgtpisvaytpslpDDRLSVSSND 399
Cdd:PLN03076  303 MLDAKYWEI------SMY---------KSAL----EGRKGELADGEVEK---------------------DDDLEVQIGN 342

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624  400 TqesgnssgpspgakfshiLQKDAFLVFRSLCKLSMK-PLSDGPPDPKSheLRSKILSLQLLLSILQNAGPVFRTNEMFI 478
Cdd:PLN03076  343 K------------------LRRDAFLVFRALCKLSMKtPPKEALADPQL--MRGKILALELLKILLENAGAVFRTSDRFL 402

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624  479 NAIKQYLCVALSKNGVSSVPEVFELSLSIFLTLLSNFKTHLKMQIEVFFKEIFLYILET-STSSFDHKWMVIQTLTRICA 557
Cdd:PLN03076  403 GAIKQYLCLSLLKNSASSLMIIFQLSCSIFISLVSRFRAGLKAEIGVFFPMIVLRVLENvAQPNFQQKMIVLRFLDKLCV 482

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624  558 DAQSVVDIYVNYDCDLNAANIFERLVNDLSKIAQG-RGSQELGMSNVQELSLRKKGLECLVSILKCMVEWSKDQYVNPNS 636
Cdd:PLN03076  483 DSQILVDIFINYDCDVNSSNIFERMVNGLLKTAQGvPPGVETTLLPPQEAAMKLEAMKCLVAILRSMGDWMNKQLRLPDP 562

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624  637 QTTlgqEKPSEQEMS-EIKHPETINRYGSLNSLESTSssgigsYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKPKR 715
Cdd:PLN03076  563 ASL---KKLDAVENNlEPGSLPVANGNGDENGEGSDS------HSELSSETSDAATIEQRRAYKLELQEGISLFNRKPKK 633

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624  716 GIQYLQEQGMLGTTPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRMFLEGFRLPGEAQ 795
Cdd:PLN03076  634 GIEFLINANKVGESPEEIAAFLKDASGLNKTLIGDYLGEREDLSLKVMHAYVDSFDFQGMEFDEAIRAFLQGFRLPGEAQ 713

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624  796 KIDRLMEKFAARYLECNqgQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSAIYN 875
Cdd:PLN03076  714 KIDRIMEKFAERYCKCN--PKAFSSADTAYVLAYSVIMLNTDAHNPMVKNKMSADDFIRNNRGIDDGKDLPEEFMRSLYE 791

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624  876 EIAGKKISMKEtkELTIPTKssKQNVASEKQRRLLYNLEMEQMAKTAKALMEA----VSHVQAPFT-----------SAT 940
Cdd:PLN03076  792 RISKNEIKMKE--DDLVPQQ--KQSANSNRILGLDSILNIVIRKRGEDSYMETsddlIKHMQEQFKekarksesvyyAAT 867

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624  941 HLEHVRPMFKLAWTPFLAAFSVGLQDCDDTEVASLCLEGIRCAIRIACIFSIQLERDAYVQALARFTLLTVSSGItemKQ 1020
Cdd:PLN03076  868 DVVILRFMVEVCWAPMLAAFSVPLDQSDDEVVTFQCLEGFRHAIHVTAVMSMKTHRDAFVTSLAKFTSLHSPADI---KQ 944

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624 1021 KNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQLIGTGVKP---------------RYISGTV--------RGR- 1076
Cdd:PLN03076  945 KNIDAIKAIVSIADEDGNYLQEAWEHILTCVSRFEHLHLLGEGAPPdatffaapqnesdksKQAKSPIlpvlkrkgPGKl 1024

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624 1077 ----EGSLTGTKDQAPdefVGlGLVGGNVDWKQIASIQESIGETsSQSVVVAVDRIFTGSTRLDGNAIVDFVRWLCAVSM 1152
Cdd:PLN03076 1025 qyaaAAVRRGSYDSAG---VG-GKASGVVTSEQMNNLVSNLNML-EQVGSFEMNRIFTRSQKLNSEAIIDFVKALCKVSM 1099

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624 1153 DELLSTTHPRMFSLQKIVEISYYNMGRIRLQWSRIWEVIGDHFNKVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRF 1232
Cdd:PLN03076 1100 EELRSPSDPRVFSLTKIVEIAHYNMNRIRLVWSSIWHVLSDFFVTIGCSENLSIAIFAMDSLRQLSMKFLEREELANYNF 1179

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624 1233 QKDFLRPFEHIMKRNRSPTIRDMVVRCIAQMVNSQAANIRSGWKNIFSVFHLAASDQDESIVELAFQTTGHIVtlvfEKH 1312
Cdd:PLN03076 1180 QNEFMKPFVIVMRKSNAVEIRELIIRCVSQMVLSRVNNVKSGWKSMFMVFTTAAYDDHKNIVLLAFEIIEKII----REY 1255

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624 1313 FPATID----SFQDAVKCLSEFACNAAFPDTSMEAIRLIRHCAKYVSDRPQAFKEYTSDDMNVAPEDRVWVRG------- 1381
Cdd:PLN03076 1256 FPYITEtettTFTDCVNCLIAFTNSRFNKDISLNAIAFLRFCATKLAEGDLGSSSRNKDKEAPPSSPQSGKDGkqesgef 1335

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624 1382 ---------WFPILFELSCIINRCKLDVRTRGLTVMFEIMKTYGHTYEKHWWQDLFRIV-FRIFDNMK---------LPE 1442
Cdd:PLN03076 1336 tdkddhlyfWFPLLAGLSELSFDPRPEIRKSALQVLFDTLRNHGHLFSLPLWERVFESVlFPIFDYVRhaidpsggdEPE 1415

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624 1443 QQTEKAE--------WMTTTCNHALYAICDVFTQYLEVLsDVLLDDIFAQLYWCVQQDNEQLARSGTNCLENVVILNGEK 1514
Cdd:PLN03076 1416 GQGVDGDqgeldqdaWLYETCTLALQLVVDLFVKFYPTV-NPLLKKVLMLLVSFIKRPHQSLAGIGIAAFVRLMSNAGHL 1494

                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624 1515 FTLEIWDKTCNCTLDIFKTTIPHAlltwrptsgetappppspDTISQKSVDIHDSVQPRSVDNRPQAPLVSASAVNEevs 1594
Cdd:PLN03076 1495 FSDEKWLEVVLSLKEAANATLPDF------------------SYVVSGEYMPAENIQDSENAEAASSSTADNDAEAE--- 1553

                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624 1595 kikstakfPEQKLFAALL-IKC--VVQLELIQTIDNIVffpatskkedaenlaaaqrdavdfdvrvdtqdqGMYR-FLTS 1670
Cdd:PLN03076 1554 --------RSRRLYAAISdAKCraAVQLLLIQAVMEIY---------------------------------NMYRpRLSA 1592

                        1770      1780      1790      1800      1810      1820      1830      1840
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624 1671 QQLFKLLDCLLESHRFAKAFNSNNEQRTALWKAGFKGKSK-PNLLKQETSSLACGLRILFRMYMDESRVSAWEEVQQRLL 1749
Cdd:PLN03076 1593 KNTLVLFDALHTVASHAHKINSDTALRSKLQELGSMTQMQdPPLLRLENESYQICLTFLQNLILDKPPLAKEAEVESRLV 1672

                        1850
                  ....*....|.
gi 966958624 1750 NVCSEALSYFL 1760
Cdd:PLN03076 1673 ELCEEVLQFYI 1683
Sec7 pfam01369
Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 ...
 698-882 2.64e-101

Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family.


Pssm-ID: 460178  Cd Length: 183  Bit Score: 322.49  E-value: 2.64e-101
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624   698 QKEIIEQGIDLFNKKPKRGIQYLQEQGMLGTTPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDF 777
Cdd:pfam01369    1 RKKLLREGIEKFNKKPKKGIEYLIEKGFIEDDPESIAKFLFETPGLDKKAIGEYLGKPDEFNIEVLKAFVDLFDFKGLRI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624   778 VSALRMFLEGFRLPGEAQKIDRLMEKFAARYLECNQGqtLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNR 857
Cdd:pfam01369   81 DEALRLFLESFRLPGEAQKIDRIMEAFAERYYEQNPG--VFANADAAYVLAYSIIMLNTDLHNPNVKKKMTLEDFIRNLR 158

                          170       180
                   ....*....|....*....|....*
gi 966958624   858 GINDSKDLPEEYLSAIYNEIAGKKI 882
Cdd:pfam01369  159 GINDGKDFPDEYLEEIYDSIKKNEI 183
Sec7 cd00171
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the ...
 698-882 3.51e-91

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor activity.


Pssm-ID: 238100  Cd Length: 185  Bit Score: 293.75  E-value: 3.51e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624  698 QKEIIEQGIDLFNKKPKRGIQYLQEQGML-GTTPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKD 776
Cdd:cd00171     1 RKTLLSEGRQLFNRKPKKGISFLIEKGFLeDDSPKEIAKFLYETEGLNKKAIGEYLGENNEFNSLVLHEFVDLFDFSGLR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624  777 FVSALRMFLEGFRLPGEAQKIDRLMEKFAARYLECNQGqTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMN 856
Cdd:cd00171    81 LDEALRKFLQSFRLPGEAQKIDRLLEKFSERYCECNPG-IFSSSADAAYTLAYSIIMLNTDLHNPNVKKKMTLEDFIKNL 159

                         170       180
                  ....*....|....*....|....*.
gi 966958624  857 RGINDSKDLPEEYLSAIYNEIAGKKI 882
Cdd:cd00171   160 RGINDGEDFPREFLKELYDSIKNNEI 185
Sec7 smart00222
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for ...
 695-882 4.10e-85

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for proper protein transport through the Golgi. The domain facilitates guanine nucleotide exchange on the small GTPases, ARFs (ADP ribosylation factors).


Pssm-ID: 214569 [Multi-domain]  Cd Length: 189  Bit Score: 276.48  E-value: 4.10e-85
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624    695 LKQQKEIIEQGIDLFNKKPKRGIQYLQEQGMLGT-TPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFS 773
Cdd:smart00222    1 SKGRKKLLSEGIVKFNDKPKKGIQSLQEKGFLANeDPQDVADFLSKNEGLNKKAIGDYLGEHDEFNRLVLHAFVDLFDFS 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624    774 GKDFVSALRMFLEGFRLPGEAQKIDRLMEKFAARYLECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYI 853
Cdd:smart00222   81 AKDLDQALREFLESFRLPGEAQKIDRLLEAFSSRYCECNPGVFSKANADAAYTLAYSLIMLNTDLHNPNVKKKMTLEDFI 160

                           170       180
                    ....*....|....*....|....*....
gi 966958624    854 KMNRGINDSKDLPEEYLSAIYNEIAGKKI 882
Cdd:smart00222  161 KNVRGSNDGEDLPREFLEELYDSIKNNEI 189
 
Name Accession Description Interval E-value
PLN03076 PLN03076
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
 15-1760 0e+00

ARF guanine nucleotide exchange factor (ARF-GEF); Provisional


Pssm-ID: 215560 [Multi-domain]  Cd Length: 1780  Bit Score: 1012.05  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624   15 ALEKILADKEVKKahHSQLRKACEVALEEIKAETEKQSPP--HGEAKAGSSTLP-PVKSKT----NFIEADKYFLPFELA 87
Cdd:PLN03076   17 ALEKIIKNASWRK--HSKLAHECKAVIERLNSPEKNPPSTssAAADSASASSLPgPLHDGGsieySLAESELILSPLINA 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624   88 CQSKCPRIVSTSLDCLQKLIAYGHLTGNAPDSTTPGKKLIDRIIETICGCFQgpQTDEGVQLQIIKALLTAVTSQHIEIH 167
Cdd:PLN03076   95 CGTGSAKIVDPALDCIQKLIAHGYLRGEADPSGGPEALLLAKLIESVCKCHD--LGDEGIELLVLKTLLSAVTSTSLRIH 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624  168 EGTVLQAVRTCYNIYLASKNLINQTTAKATLTQMLNVIFARMEN-------QALQEAKQMEK-ERhrqqqhllqSPVSHH 239
Cdd:PLN03076  173 GDCLLQAVRTCYDIYLGSKNVVNQTTAKASLIQMLVIVFRRMEAdsstvpiQPIVVAELMEPaEK---------SDSDTS 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624  240 EPESPQlrylppQTVDHISQeherdldlhtnDVDKSLQddtePENGSDISSAENEQTEADQATAAETLSKNDMLYDGENH 319
Cdd:PLN03076  244 MTQFVQ------GFITKIMQ-----------DIDGVLN----PATAGKSSGSGAHDGAFETTATVETTNPADLLDSTDKD 302

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624  320 DCEEKPQDIvqniveEMVnivvgdmgeRTAInasaDGNIGTIEDGSDSEniqangipgtpisvaytpslpDDRLSVSSND 399
Cdd:PLN03076  303 MLDAKYWEI------SMY---------KSAL----EGRKGELADGEVEK---------------------DDDLEVQIGN 342

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624  400 TqesgnssgpspgakfshiLQKDAFLVFRSLCKLSMK-PLSDGPPDPKSheLRSKILSLQLLLSILQNAGPVFRTNEMFI 478
Cdd:PLN03076  343 K------------------LRRDAFLVFRALCKLSMKtPPKEALADPQL--MRGKILALELLKILLENAGAVFRTSDRFL 402

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624  479 NAIKQYLCVALSKNGVSSVPEVFELSLSIFLTLLSNFKTHLKMQIEVFFKEIFLYILET-STSSFDHKWMVIQTLTRICA 557
Cdd:PLN03076  403 GAIKQYLCLSLLKNSASSLMIIFQLSCSIFISLVSRFRAGLKAEIGVFFPMIVLRVLENvAQPNFQQKMIVLRFLDKLCV 482

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624  558 DAQSVVDIYVNYDCDLNAANIFERLVNDLSKIAQG-RGSQELGMSNVQELSLRKKGLECLVSILKCMVEWSKDQYVNPNS 636
Cdd:PLN03076  483 DSQILVDIFINYDCDVNSSNIFERMVNGLLKTAQGvPPGVETTLLPPQEAAMKLEAMKCLVAILRSMGDWMNKQLRLPDP 562

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624  637 QTTlgqEKPSEQEMS-EIKHPETINRYGSLNSLESTSssgigsYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKPKR 715
Cdd:PLN03076  563 ASL---KKLDAVENNlEPGSLPVANGNGDENGEGSDS------HSELSSETSDAATIEQRRAYKLELQEGISLFNRKPKK 633

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624  716 GIQYLQEQGMLGTTPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRMFLEGFRLPGEAQ 795
Cdd:PLN03076  634 GIEFLINANKVGESPEEIAAFLKDASGLNKTLIGDYLGEREDLSLKVMHAYVDSFDFQGMEFDEAIRAFLQGFRLPGEAQ 713

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624  796 KIDRLMEKFAARYLECNqgQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSAIYN 875
Cdd:PLN03076  714 KIDRIMEKFAERYCKCN--PKAFSSADTAYVLAYSVIMLNTDAHNPMVKNKMSADDFIRNNRGIDDGKDLPEEFMRSLYE 791

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624  876 EIAGKKISMKEtkELTIPTKssKQNVASEKQRRLLYNLEMEQMAKTAKALMEA----VSHVQAPFT-----------SAT 940
Cdd:PLN03076  792 RISKNEIKMKE--DDLVPQQ--KQSANSNRILGLDSILNIVIRKRGEDSYMETsddlIKHMQEQFKekarksesvyyAAT 867

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624  941 HLEHVRPMFKLAWTPFLAAFSVGLQDCDDTEVASLCLEGIRCAIRIACIFSIQLERDAYVQALARFTLLTVSSGItemKQ 1020
Cdd:PLN03076  868 DVVILRFMVEVCWAPMLAAFSVPLDQSDDEVVTFQCLEGFRHAIHVTAVMSMKTHRDAFVTSLAKFTSLHSPADI---KQ 944

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624 1021 KNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQLIGTGVKP---------------RYISGTV--------RGR- 1076
Cdd:PLN03076  945 KNIDAIKAIVSIADEDGNYLQEAWEHILTCVSRFEHLHLLGEGAPPdatffaapqnesdksKQAKSPIlpvlkrkgPGKl 1024

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624 1077 ----EGSLTGTKDQAPdefVGlGLVGGNVDWKQIASIQESIGETsSQSVVVAVDRIFTGSTRLDGNAIVDFVRWLCAVSM 1152
Cdd:PLN03076 1025 qyaaAAVRRGSYDSAG---VG-GKASGVVTSEQMNNLVSNLNML-EQVGSFEMNRIFTRSQKLNSEAIIDFVKALCKVSM 1099

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624 1153 DELLSTTHPRMFSLQKIVEISYYNMGRIRLQWSRIWEVIGDHFNKVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRF 1232
Cdd:PLN03076 1100 EELRSPSDPRVFSLTKIVEIAHYNMNRIRLVWSSIWHVLSDFFVTIGCSENLSIAIFAMDSLRQLSMKFLEREELANYNF 1179

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624 1233 QKDFLRPFEHIMKRNRSPTIRDMVVRCIAQMVNSQAANIRSGWKNIFSVFHLAASDQDESIVELAFQTTGHIVtlvfEKH 1312
Cdd:PLN03076 1180 QNEFMKPFVIVMRKSNAVEIRELIIRCVSQMVLSRVNNVKSGWKSMFMVFTTAAYDDHKNIVLLAFEIIEKII----REY 1255

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624 1313 FPATID----SFQDAVKCLSEFACNAAFPDTSMEAIRLIRHCAKYVSDRPQAFKEYTSDDMNVAPEDRVWVRG------- 1381
Cdd:PLN03076 1256 FPYITEtettTFTDCVNCLIAFTNSRFNKDISLNAIAFLRFCATKLAEGDLGSSSRNKDKEAPPSSPQSGKDGkqesgef 1335

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624 1382 ---------WFPILFELSCIINRCKLDVRTRGLTVMFEIMKTYGHTYEKHWWQDLFRIV-FRIFDNMK---------LPE 1442
Cdd:PLN03076 1336 tdkddhlyfWFPLLAGLSELSFDPRPEIRKSALQVLFDTLRNHGHLFSLPLWERVFESVlFPIFDYVRhaidpsggdEPE 1415

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624 1443 QQTEKAE--------WMTTTCNHALYAICDVFTQYLEVLsDVLLDDIFAQLYWCVQQDNEQLARSGTNCLENVVILNGEK 1514
Cdd:PLN03076 1416 GQGVDGDqgeldqdaWLYETCTLALQLVVDLFVKFYPTV-NPLLKKVLMLLVSFIKRPHQSLAGIGIAAFVRLMSNAGHL 1494

                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624 1515 FTLEIWDKTCNCTLDIFKTTIPHAlltwrptsgetappppspDTISQKSVDIHDSVQPRSVDNRPQAPLVSASAVNEevs 1594
Cdd:PLN03076 1495 FSDEKWLEVVLSLKEAANATLPDF------------------SYVVSGEYMPAENIQDSENAEAASSSTADNDAEAE--- 1553

                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624 1595 kikstakfPEQKLFAALL-IKC--VVQLELIQTIDNIVffpatskkedaenlaaaqrdavdfdvrvdtqdqGMYR-FLTS 1670
Cdd:PLN03076 1554 --------RSRRLYAAISdAKCraAVQLLLIQAVMEIY---------------------------------NMYRpRLSA 1592

                        1770      1780      1790      1800      1810      1820      1830      1840
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624 1671 QQLFKLLDCLLESHRFAKAFNSNNEQRTALWKAGFKGKSK-PNLLKQETSSLACGLRILFRMYMDESRVSAWEEVQQRLL 1749
Cdd:PLN03076 1593 KNTLVLFDALHTVASHAHKINSDTALRSKLQELGSMTQMQdPPLLRLENESYQICLTFLQNLILDKPPLAKEAEVESRLV 1672

                        1850
                  ....*....|.
gi 966958624 1750 NVCSEALSYFL 1760
Cdd:PLN03076 1673 ELCEEVLQFYI 1683
Sec7 pfam01369
Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 ...
 698-882 2.64e-101

Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family.


Pssm-ID: 460178  Cd Length: 183  Bit Score: 322.49  E-value: 2.64e-101
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624   698 QKEIIEQGIDLFNKKPKRGIQYLQEQGMLGTTPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDF 777
Cdd:pfam01369    1 RKKLLREGIEKFNKKPKKGIEYLIEKGFIEDDPESIAKFLFETPGLDKKAIGEYLGKPDEFNIEVLKAFVDLFDFKGLRI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624   778 VSALRMFLEGFRLPGEAQKIDRLMEKFAARYLECNQGqtLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNR 857
Cdd:pfam01369   81 DEALRLFLESFRLPGEAQKIDRIMEAFAERYYEQNPG--VFANADAAYVLAYSIIMLNTDLHNPNVKKKMTLEDFIRNLR 158

                          170       180
                   ....*....|....*....|....*
gi 966958624   858 GINDSKDLPEEYLSAIYNEIAGKKI 882
Cdd:pfam01369  159 GINDGKDFPDEYLEEIYDSIKKNEI 183
Sec7 cd00171
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the ...
 698-882 3.51e-91

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor activity.


Pssm-ID: 238100  Cd Length: 185  Bit Score: 293.75  E-value: 3.51e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624  698 QKEIIEQGIDLFNKKPKRGIQYLQEQGML-GTTPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKD 776
Cdd:cd00171     1 RKTLLSEGRQLFNRKPKKGISFLIEKGFLeDDSPKEIAKFLYETEGLNKKAIGEYLGENNEFNSLVLHEFVDLFDFSGLR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624  777 FVSALRMFLEGFRLPGEAQKIDRLMEKFAARYLECNQGqTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMN 856
Cdd:cd00171    81 LDEALRKFLQSFRLPGEAQKIDRLLEKFSERYCECNPG-IFSSSADAAYTLAYSIIMLNTDLHNPNVKKKMTLEDFIKNL 159

                         170       180
                  ....*....|....*....|....*.
gi 966958624  857 RGINDSKDLPEEYLSAIYNEIAGKKI 882
Cdd:cd00171   160 RGINDGEDFPREFLKELYDSIKNNEI 185
Sec7 smart00222
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for ...
 695-882 4.10e-85

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for proper protein transport through the Golgi. The domain facilitates guanine nucleotide exchange on the small GTPases, ARFs (ADP ribosylation factors).


Pssm-ID: 214569 [Multi-domain]  Cd Length: 189  Bit Score: 276.48  E-value: 4.10e-85
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624    695 LKQQKEIIEQGIDLFNKKPKRGIQYLQEQGMLGT-TPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFS 773
Cdd:smart00222    1 SKGRKKLLSEGIVKFNDKPKKGIQSLQEKGFLANeDPQDVADFLSKNEGLNKKAIGDYLGEHDEFNRLVLHAFVDLFDFS 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624    774 GKDFVSALRMFLEGFRLPGEAQKIDRLMEKFAARYLECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYI 853
Cdd:smart00222   81 AKDLDQALREFLESFRLPGEAQKIDRLLEAFSSRYCECNPGVFSKANADAAYTLAYSLIMLNTDLHNPNVKKKMTLEDFI 160

                           170       180
                    ....*....|....*....|....*....
gi 966958624    854 KMNRGINDSKDLPEEYLSAIYNEIAGKKI 882
Cdd:smart00222  161 KNVRGSNDGEDLPREFLEELYDSIKNNEI 189
BIG2_C pfam20252
BIG2 C-terminal domain; This presumed domain is found at the C-terminus of BIG2 the brefeldin ...
 1616-1822 3.98e-59

BIG2 C-terminal domain; This presumed domain is found at the C-terminus of BIG2 the brefeldin A-inhibited guanine nucleotide-exchange protein. The function of this region is unknown.


Pssm-ID: 466403  Cd Length: 178  Bit Score: 201.31  E-value: 3.98e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624  1616 VVQLELIQTIDNIVffpatskkedaenlaaaqrdavdfdvrvdtqdQGMYRFLTSQQLFKLLDCLLESHRFAKAFNSNNE 1695
Cdd:pfam20252    1 VVQLLLIQTVNEIL--------------------------------DEHYESLPSDHLLRLLDCLEKSYTFARSFNSDLE 48

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624  1696 QRTALWKAGFkGKSKPNLLKQETSSLACGLRILFRMYMDES-RVSAWEEVQQRLLNVCSEALSYFLTL-TSESHRE--AW 1771
Cdd:pfam20252   49 LRTALWRAGF-MKQLPNLLKQETSSLSTYLRILFRLYADDEpRTSQREEVEERLIPLCEDILEYYLSLdEEEKQRElaAW 127

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 966958624  1772 TNLLLLFLTKVLKISDNRFKAHASFYYPLLCEIMQFDLIPELRAVLRRFFL 1822
Cdd:pfam20252  128 TPVVVLILQGLLALPDDDFRRHLPEFYPLLCDLILCELSPEVRLALREFFS 178
DCB pfam16213
dimerization and cyclophilin-binding domain of Mon2; DCB is the N-terminal domain of Mon2- and ...
 29-209 5.69e-52

dimerization and cyclophilin-binding domain of Mon2; DCB is the N-terminal domain of Mon2- and GIG1-like proteins from metazoa. Mon2 and BIG1 like proteins play an important role in the cytoplasm-to-vacuole transport pathway and are required for Golgi homeostasis.


Pssm-ID: 465072 [Multi-domain]  Cd Length: 172  Bit Score: 180.91  E-value: 5.69e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624    29 HHSQLRKACEVALEEIKAETEKQSPP-HGEAKAGSSTLPPVKSK----TNFIEA-DKYFLPFELACQSKCPRIVSTSLDC 102
Cdd:pfam16213    1 QGSKLLEALQSDLRTLSSEAKRKYPPvKEASEKGILRLRTVHSSsplmQNLLSAsEDILKPFVLACETKNPKLVQIALGC 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624   103 LQKLIAYGHLTGNApdsttpgkklIDRIIETICGCFQGPQTdegVQLQIIKALLTAVTSQHIeIHEGTVLQAVRTCYNIY 182
Cdd:pfam16213   81 LQKLISHDAISQSA----------APYILDTLWMLMELGSE---IELKVLQTVLLLITTNSV-IHGDTLAKALVLCFRLH 146

                          170       180
                   ....*....|....*....|....*..
gi 966958624   183 LaSKNLINQTTAKATLTQMLNVIFARM 209
Cdd:pfam16213  147 F-SKDPTVQNTASATLRQLVSVVFERV 172
Sec7_N pfam12783
Guanine nucleotide exchange factor in Golgi transport N-terminal; The full-length Sec7 ...
 419-574 7.39e-52

Guanine nucleotide exchange factor in Golgi transport N-terminal; The full-length Sec7 functions proximally in the secretory pathway as a protein binding scaffold for the coat protein complexes COPII-COPI. The COPII-COPI-protein switch is necessary for maturation of the vesicular-tubular cluster, VTC, intermediate compartments for Golgi compartment biogenesis. This N-terminal domain however does not appear to be binding either of the COP or the ARF.


Pssm-ID: 463703  Cd Length: 154  Bit Score: 179.61  E-value: 7.39e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624   419 LQKDAFLVFRSLCKLS-MKPLSDgpPDPKSHELRSKILSLQLLLSILQNAGPVFRTNEMFINAIKQYLCVALSKNGVSSV 497
Cdd:pfam12783    1 AAKDAFLVFRDLCKLSnGKPLSK--SDPKSHAERSKLFSLELIESILENHGDVFLKHPELLQLLKQYLCPSLLRNLSSSS 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966958624   498 PEVFELSLSIFLTLLSNFKTHLKMQIEVFFKEIFLYILEtSTSSFDHKWMVIQTLTRICADAQSVVDIYVNYDCDLN 574
Cdd:pfam12783   79 FPVFVRSLRIFLLLLRRFRSHLKLEIEVFLSLLILPLLE-SDSSLWQKALVLEVLRRLCSDPQLLVEIYLNYDCDLG 154
DUF1981 pfam09324
Domain of unknown function (DUF1981); Members of this family of functionally uncharacterized ...
 1220-1301 2.01e-39

Domain of unknown function (DUF1981); Members of this family of functionally uncharacterized domains are found in various plant and yeast protein transport proteins.


Pssm-ID: 462756  Cd Length: 84  Bit Score: 141.47  E-value: 2.01e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958624  1220 KFLEKGELANFRFQKDFLRPFEHIMKRNRSPTIRDMVVRCIAQMVNSQAANIRSGWKNIFSVFHLAASDQDESIVELAFQ 1299
Cdd:pfam09324    1 KFLEKEELSNFKFQKDFLKPFEYIMSNNSSVDVKELVLECILQMIQSKGDNIKSGWKTIFGVLTAAAKDSNESLVRLAFQ 80


                   ..
gi 966958624  1300 TT 1301
Cdd:pfam09324   81 IL 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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