NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1622959102|ref|XP_015000236|]
View 

transcription factor GATA-4 isoform X2 [Macaca mulatta]

Protein Classification

GATA-type transcription factor( domain architecture ID 11786012)

GATA-type transcription factor binds to the DNA consensus sequence [AT]GATA[AG] and may function as a transcription factor/regulator

CATH:  3.30.50.10
Gene Ontology:  GO:0003700|GO:0006357|GO:0006355|GO:0008270|GO:0043565
PubMed:  31574210
SCOP:  4003617

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
GATA-N super family cl25837
GATA-type transcription activator, N-terminal; GATA transcription factors mediate cell ...
 1-205 5.90e-30

GATA-type transcription activator, N-terminal; GATA transcription factors mediate cell differentiation in a diverse range of tissues. Mutation are often associated with certain congenital human disorders. The six classical vertebrate GATA proteins, GATA-1 to GATA-6, are highly homologous and have two tandem zinc fingers. The classical GATA transcription factors function transcription activators. In lower metazoans GATA proteins carry a single canonical zinc finger. This family represents the N-terminal domain of the family of GATA transcription activators.


The actual alignment was detected with superfamily member pfam05349:

Pssm-ID: 461628 [Multi-domain]  Cd Length: 174  Bit Score: 114.45  E-value: 5.90e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622959102   1 MYQSLAMAANHGPPPgayEAGGPGAFMHGAgaASSPVYVPTPRVPSSVLGLSYLQGGGAGSASGGAAgsssgaaasgagp 80
Cdd:pfam05349   1 MYQSLALAANHGQAA---YDHDSGGFLHSA--ASSPVYVPTTRVPSMLPTLPYLQGCGSSQQSHPVS------------- 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622959102  81 gtqqGSPGWSQAGADGAAYTP--PPVSPRFSFPGTTgslaaaaaaAAAREAAAYSSGGGAAGAGLAGREQYG--RAGFAS 156
Cdd:pfam05349  63 ----SHSGWAQAGAESSSYNPgsPHPSPRFSYSHSP---------PGSNGTSRDAAYQSPLLISAGGREQYGalGRPLGG 129

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1622959102 157 SYSSPYPAYMAdvgasWAAAAAASAGPFDSPVLHSLPGRANP-AARHPNL 205
Cdd:pfam05349 130 SYPSPYPAYVS-----PEMAPSWTAGPFDSSVLHSLQGRGAPlPGRRPNL 174
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 270-321 3.39e-21

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


:

Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 86.27  E-value: 3.39e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1622959102 270 SCANCQTTTTTLWRRN-AEGEPVCNACGLYMKLHGVPRPLAMRKEG-IQTRKRK 321
Cdd:cd00202     1 ACSNCGTTTTPLWRRGpSGGSTLCNACGLYWKKHGVMRPLSKRKKDqIKRRNRK 54
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 216-266 1.25e-17

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


:

Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 76.26  E-value: 1.25e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1622959102 216 ECVNCGAMSTPLWRRDG-TGHYLCNACGLYHKMNGINRPLIKPQRRLSASRR 266
Cdd:cd00202     1 ACSNCGTTTTPLWRRGPsGGSTLCNACGLYWKKHGVMRPLSKRKKDQIKRRN 52
 
Name Accession Description Interval E-value
GATA-N pfam05349
GATA-type transcription activator, N-terminal; GATA transcription factors mediate cell ...
 1-205 5.90e-30

GATA-type transcription activator, N-terminal; GATA transcription factors mediate cell differentiation in a diverse range of tissues. Mutation are often associated with certain congenital human disorders. The six classical vertebrate GATA proteins, GATA-1 to GATA-6, are highly homologous and have two tandem zinc fingers. The classical GATA transcription factors function transcription activators. In lower metazoans GATA proteins carry a single canonical zinc finger. This family represents the N-terminal domain of the family of GATA transcription activators.


Pssm-ID: 461628 [Multi-domain]  Cd Length: 174  Bit Score: 114.45  E-value: 5.90e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622959102   1 MYQSLAMAANHGPPPgayEAGGPGAFMHGAgaASSPVYVPTPRVPSSVLGLSYLQGGGAGSASGGAAgsssgaaasgagp 80
Cdd:pfam05349   1 MYQSLALAANHGQAA---YDHDSGGFLHSA--ASSPVYVPTTRVPSMLPTLPYLQGCGSSQQSHPVS------------- 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622959102  81 gtqqGSPGWSQAGADGAAYTP--PPVSPRFSFPGTTgslaaaaaaAAAREAAAYSSGGGAAGAGLAGREQYG--RAGFAS 156
Cdd:pfam05349  63 ----SHSGWAQAGAESSSYNPgsPHPSPRFSYSHSP---------PGSNGTSRDAAYQSPLLISAGGREQYGalGRPLGG 129

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1622959102 157 SYSSPYPAYMAdvgasWAAAAAASAGPFDSPVLHSLPGRANP-AARHPNL 205
Cdd:pfam05349 130 SYPSPYPAYVS-----PEMAPSWTAGPFDSSVLHSLQGRGAPlPGRRPNL 174
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 270-321 3.39e-21

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 86.27  E-value: 3.39e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1622959102 270 SCANCQTTTTTLWRRN-AEGEPVCNACGLYMKLHGVPRPLAMRKEG-IQTRKRK 321
Cdd:cd00202     1 ACSNCGTTTTPLWRRGpSGGSTLCNACGLYWKKHGVMRPLSKRKKDqIKRRNRK 54
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 216-266 1.25e-17

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 76.26  E-value: 1.25e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1622959102 216 ECVNCGAMSTPLWRRDG-TGHYLCNACGLYHKMNGINRPLIKPQRRLSASRR 266
Cdd:cd00202     1 ACSNCGTTTTPLWRRGPsGGSTLCNACGLYWKKHGVMRPLSKRKKDQIKRRN 52
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
268-315 1.86e-17

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 75.92  E-value: 1.86e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1622959102  268 GLSCANCQTTTTTLWRRNAEGE-PVCNACGLYMKLHGVP-RPLAMRKEGI 315
Cdd:smart00401   3 GRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGLkRPLSLKKDGI 52
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 271-305 3.08e-14

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 66.19  E-value: 3.08e-14
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1622959102 271 CANCQTTTTTLWRRNAEGEP-VCNACGLYMKLHGVP 305
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGLK 36
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
212-257 5.53e-14

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 65.90  E-value: 5.53e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1622959102  212 SEGRECVNCGAMSTPLWRRDGTGH-YLCNACGLYHKMNGI-NRPLIKP 257
Cdd:smart00401   1 GSGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGlKRPLSLK 48
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 217-249 2.53e-12

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 60.79  E-value: 2.53e-12
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1622959102 217 CVNCGAMSTPLWRRDGTGHY-LCNACGLYHKMNG 249
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKG 34
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
192-324 2.20e-07

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 52.95  E-value: 2.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622959102 192 LPGRANPAARHPNLDMFDDFSegRECVNCGAMSTPLWRRD-----GTGHYLCNACGLYHKMNGINRPLIKPQRRLSASRR 266
Cdd:COG5641   138 NPGGTSSLNPNNNQSDNSNQP--HVCSNCKTTSTPLWRRAssessLPGNNLCNACGLYLKLHGSPRAPISLKSDSIKSRS 215

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622959102 267 VGLSCANCQTTT-TTLWRRNAEGEPVCNACGLYMKLHGvpRPLAMRKEGIQTRKRKPKN 324
Cdd:COG5641   216 SRSSHNNNDSNGeNANTESIGNSSASKLTKSWEERPQG--RQLLSDAGSLSPRSNNPKS 272
 
Name Accession Description Interval E-value
GATA-N pfam05349
GATA-type transcription activator, N-terminal; GATA transcription factors mediate cell ...
 1-205 5.90e-30

GATA-type transcription activator, N-terminal; GATA transcription factors mediate cell differentiation in a diverse range of tissues. Mutation are often associated with certain congenital human disorders. The six classical vertebrate GATA proteins, GATA-1 to GATA-6, are highly homologous and have two tandem zinc fingers. The classical GATA transcription factors function transcription activators. In lower metazoans GATA proteins carry a single canonical zinc finger. This family represents the N-terminal domain of the family of GATA transcription activators.


Pssm-ID: 461628 [Multi-domain]  Cd Length: 174  Bit Score: 114.45  E-value: 5.90e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622959102   1 MYQSLAMAANHGPPPgayEAGGPGAFMHGAgaASSPVYVPTPRVPSSVLGLSYLQGGGAGSASGGAAgsssgaaasgagp 80
Cdd:pfam05349   1 MYQSLALAANHGQAA---YDHDSGGFLHSA--ASSPVYVPTTRVPSMLPTLPYLQGCGSSQQSHPVS------------- 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622959102  81 gtqqGSPGWSQAGADGAAYTP--PPVSPRFSFPGTTgslaaaaaaAAAREAAAYSSGGGAAGAGLAGREQYG--RAGFAS 156
Cdd:pfam05349  63 ----SHSGWAQAGAESSSYNPgsPHPSPRFSYSHSP---------PGSNGTSRDAAYQSPLLISAGGREQYGalGRPLGG 129

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1622959102 157 SYSSPYPAYMAdvgasWAAAAAASAGPFDSPVLHSLPGRANP-AARHPNL 205
Cdd:pfam05349 130 SYPSPYPAYVS-----PEMAPSWTAGPFDSSVLHSLQGRGAPlPGRRPNL 174
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 270-321 3.39e-21

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 86.27  E-value: 3.39e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1622959102 270 SCANCQTTTTTLWRRN-AEGEPVCNACGLYMKLHGVPRPLAMRKEG-IQTRKRK 321
Cdd:cd00202     1 ACSNCGTTTTPLWRRGpSGGSTLCNACGLYWKKHGVMRPLSKRKKDqIKRRNRK 54
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 216-266 1.25e-17

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 76.26  E-value: 1.25e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1622959102 216 ECVNCGAMSTPLWRRDG-TGHYLCNACGLYHKMNGINRPLIKPQRRLSASRR 266
Cdd:cd00202     1 ACSNCGTTTTPLWRRGPsGGSTLCNACGLYWKKHGVMRPLSKRKKDQIKRRN 52
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
268-315 1.86e-17

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 75.92  E-value: 1.86e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1622959102  268 GLSCANCQTTTTTLWRRNAEGE-PVCNACGLYMKLHGVP-RPLAMRKEGI 315
Cdd:smart00401   3 GRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGLkRPLSLKKDGI 52
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 271-305 3.08e-14

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 66.19  E-value: 3.08e-14
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1622959102 271 CANCQTTTTTLWRRNAEGEP-VCNACGLYMKLHGVP 305
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGLK 36
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
212-257 5.53e-14

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 65.90  E-value: 5.53e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1622959102  212 SEGRECVNCGAMSTPLWRRDGTGH-YLCNACGLYHKMNGI-NRPLIKP 257
Cdd:smart00401   1 GSGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGlKRPLSLK 48
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 217-249 2.53e-12

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 60.79  E-value: 2.53e-12
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1622959102 217 CVNCGAMSTPLWRRDGTGHY-LCNACGLYHKMNG 249
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKG 34
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
192-324 2.20e-07

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 52.95  E-value: 2.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622959102 192 LPGRANPAARHPNLDMFDDFSegRECVNCGAMSTPLWRRD-----GTGHYLCNACGLYHKMNGINRPLIKPQRRLSASRR 266
Cdd:COG5641   138 NPGGTSSLNPNNNQSDNSNQP--HVCSNCKTTSTPLWRRAssessLPGNNLCNACGLYLKLHGSPRAPISLKSDSIKSRS 215

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622959102 267 VGLSCANCQTTT-TTLWRRNAEGEPVCNACGLYMKLHGvpRPLAMRKEGIQTRKRKPKN 324
Cdd:COG5641   216 SRSSHNNNDSNGeNANTESIGNSSASKLTKSWEERPQG--RQLLSDAGSLSPRSNNPKS 272
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
219-334 1.49e-06

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 50.25  E-value: 1.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622959102 219 NCGAMSTPLWRR-DGTGHYLCNACGLYHKMNGINRPLikPQRRLSASRRVGLSCANCQTTTTTLWRrnaEGEPVCNACGL 297
Cdd:COG5641   303 LTTSTATPLWRRtSDKSSFSCNASGSALKPPGSKRPL--LPKPDPNSKRSNATCMNCSSTPTNKIL---SPPTTSNSPGA 377

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1622959102 298 YMKLHGVPRPLAMRKEGIQTRKRKPKN---LNKSKTPAGP 334
Cdd:COG5641   378 QVKLPNQTRSTGATKKKITRRRMNSGKipaLSSSMKNPVP 417
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH