NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1622831293|ref|XP_015000224|]
View 

bromodomain testis-specific protein isoform X1 [Macaca mulatta]

Protein Classification

Bromo_Brdt_I_like and Bromo_Brdt_II_like domain-containing protein( domain architecture ID 10860762)

protein containing domains Bromo_Brdt_I_like, Bromo_Brdt_II_like, BET, and BRD4_CDT

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Bromo_Brdt_I_like cd05497
Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET ...
 27-133 2.60e-70

Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


:

Pssm-ID: 99929  Cd Length: 107  Bit Score: 228.07  E-value: 2.60e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293  27 RLTNQLQYLQKVVLKDLWKHSFSWPFQRPVDAVKLKLPDYYTIIKNPMDLNTIKKRLENKYYVKASECIEDFNTMFSNCY 106
Cdd:cd05497     1 RHTNQLQYLLKVVLKALWKHKFAWPFQQPVDAVKLNLPDYHKIIKTPMDLGTIKKRLENNYYWSASECIQDFNTMFTNCY 80

                          90       100
                  ....*....|....*....|....*..
gi 1622831293 107 LYNKPGDDIVLMAQALEKLFMQKLSQM 133
Cdd:cd05497    81 IYNKPGDDVVLMAQTLEKLFLQKLAQM 107
Bromo_Brdt_II_like cd05498
Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET ...
 272-373 1.55e-60

Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


:

Pssm-ID: 99930  Cd Length: 102  Bit Score: 200.97  E-value: 1.55e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293 272 QLRHCSEILKEMLAKKHFSYAWPFYNPVDVNALGLHNYYDIVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKY 351
Cdd:cd05498     1 QLKFCSGILKELFSKKHKAYAWPFYKPVDPEALGLHDYHDIIKHPMDLSTIKKKLDNREYADAQEFAADVRLMFSNCYKY 80

                          90       100
                  ....*....|....*....|..
gi 1622831293 352 NPPDHEVVTMARMLQDVFETHF 373
Cdd:cd05498    81 NPPDHPVHAMARKLQDVFEDRW 102
BET pfam17035
Bromodomain extra-terminal - transcription regulation; The BET, or bromodomain extra-terminal ...
 509-571 8.21e-24

Bromodomain extra-terminal - transcription regulation; The BET, or bromodomain extra-terminal domain, is found on bromodomain proteins that play key roles in development, cancer progression and virus-host pathogenesis. It interacts with NSD3, JMJD6, CHD4, GLTSCR1, and ATAD5 all of which are shown to impart a pTEFb-independent transcriptional activation function on the bromodomain proteins.


:

Pssm-ID: 435704  Cd Length: 64  Bit Score: 95.25  E-value: 8.21e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622831293 509 PMNYDEKRQLSLNINKLPGDKLGRVVHIIQSREPSLsNSNPDEIEIDFETLKASTLRELEKYV 571
Cdd:pfam17035   1 PMTYEEKRELSERINKLPGEKLGRVIEIIKERNPEL-QSDDDEIELDIDALDDDTLRKLYNFV 62
BRD4_CDT pfam17105
C-terminal domain of bromodomain protein 4; BRD4_CDT is the short highly conserved C-terminal ...
 905-947 2.58e-10

C-terminal domain of bromodomain protein 4; BRD4_CDT is the short highly conserved C-terminal domain of certain bromodomain proteins, notably Brd4. The Brd4 CTD interacts with the cyclin T1 and Cdk9 subunits of positive transcription elongation factor b (pTEFb) complex. Brd4 displaces negative regulators, the HEXIM1 and 7SKsnRNA complex, from pTEFb, thereby transforming it into an active form that can phosphorylate RNA pol II.


:

Pssm-ID: 465349  Cd Length: 44  Bit Score: 56.25  E-value: 2.58e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1622831293 905 WLLKDRNLAREKEQERRRREAMAGTIDMTLQSDIMTMFENNFD 947
Cdd:pfam17105   2 SLDKERELARKREQERRRREAMAGTIDMNLQSDIMASFEENLD 44
 
Name Accession Description Interval E-value
Bromo_Brdt_I_like cd05497
Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET ...
 27-133 2.60e-70

Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99929  Cd Length: 107  Bit Score: 228.07  E-value: 2.60e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293  27 RLTNQLQYLQKVVLKDLWKHSFSWPFQRPVDAVKLKLPDYYTIIKNPMDLNTIKKRLENKYYVKASECIEDFNTMFSNCY 106
Cdd:cd05497     1 RHTNQLQYLLKVVLKALWKHKFAWPFQQPVDAVKLNLPDYHKIIKTPMDLGTIKKRLENNYYWSASECIQDFNTMFTNCY 80

                          90       100
                  ....*....|....*....|....*..
gi 1622831293 107 LYNKPGDDIVLMAQALEKLFMQKLSQM 133
Cdd:cd05497    81 IYNKPGDDVVLMAQTLEKLFLQKLAQM 107
Bromo_Brdt_II_like cd05498
Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET ...
 272-373 1.55e-60

Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99930  Cd Length: 102  Bit Score: 200.97  E-value: 1.55e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293 272 QLRHCSEILKEMLAKKHFSYAWPFYNPVDVNALGLHNYYDIVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKY 351
Cdd:cd05498     1 QLKFCSGILKELFSKKHKAYAWPFYKPVDPEALGLHDYHDIIKHPMDLSTIKKKLDNREYADAQEFAADVRLMFSNCYKY 80

                          90       100
                  ....*....|....*....|..
gi 1622831293 352 NPPDHEVVTMARMLQDVFETHF 373
Cdd:cd05498    81 NPPDHPVHAMARKLQDVFEDRW 102
BROMO smart00297
bromo domain;
271-376 8.76e-34

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 125.47  E-value: 8.76e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293  271 EQLRHCSEILKEMLAKKHFS-YAWPFYNPVDVNALglHNYYDIVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCY 349
Cdd:smart00297   3 KLQKKLQELLKAVLDKLDSHpLSWPFLKPVSRKEA--PDYYDIIKKPMDLKTIKKKLENGKYSSVEEFVADFNLMFSNAR 80

                           90       100
                   ....*....|....*....|....*..
gi 1622831293  350 KYNPPDHEVVTMARMLQDVFETHFSKI 376
Cdd:smart00297  81 TYNGPDSEVYKDAKKLEKFFEKKLREL 107
BROMO smart00297
bromo domain;
27-133 6.41e-33

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 122.77  E-value: 6.41e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293   27 RLTNQLQYLQKVVLKDLWKHSFSWPFQRPVDAVKLklPDYYTIIKNPMDLNTIKKRLENKYYVKASECIEDFNTMFSNCY 106
Cdd:smart00297   3 KLQKKLQELLKAVLDKLDSHPLSWPFLKPVSRKEA--PDYYDIIKKPMDLKTIKKKLENGKYSSVEEFVADFNLMFSNAR 80

                           90       100
                   ....*....|....*....|....*..
gi 1622831293  107 LYNKPGDDIVLMAQALEKLFMQKLSQM 133
Cdd:smart00297  81 TYNGPDSEVYKDAKKLEKFFEKKLREL 107
BET pfam17035
Bromodomain extra-terminal - transcription regulation; The BET, or bromodomain extra-terminal ...
 509-571 8.21e-24

Bromodomain extra-terminal - transcription regulation; The BET, or bromodomain extra-terminal domain, is found on bromodomain proteins that play key roles in development, cancer progression and virus-host pathogenesis. It interacts with NSD3, JMJD6, CHD4, GLTSCR1, and ATAD5 all of which are shown to impart a pTEFb-independent transcriptional activation function on the bromodomain proteins.


Pssm-ID: 435704  Cd Length: 64  Bit Score: 95.25  E-value: 8.21e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622831293 509 PMNYDEKRQLSLNINKLPGDKLGRVVHIIQSREPSLsNSNPDEIEIDFETLKASTLRELEKYV 571
Cdd:pfam17035   1 PMTYEEKRELSERINKLPGEKLGRVIEIIKERNPEL-QSDDDEIELDIDALDDDTLRKLYNFV 62
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 39-120 1.78e-20

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 86.60  E-value: 1.78e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293  39 VLKDLWKHSFSWPFQRPVDAVKLklPDYYTIIKNPMDLNTIKKRLENKYYVKASECIEDFNTMFSNCYLYNKPGDDIVLM 118
Cdd:pfam00439   4 ILDKLMEHPIAAPFLEPVDPDEY--PDYYSVIKKPMDLSTIKKKLENGEYKSLAEFLADVKLIFSNARTYNGPGSVIYKA 81


                  ..
gi 1622831293 119 AQ 120
Cdd:pfam00439  82 AE 83
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 276-363 3.66e-18

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 80.05  E-value: 3.66e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293 276 CSEILKEMlaKKHFSYAWpFYNPVDVNALGlhNYYDIVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPD 355
Cdd:pfam00439   1 CLEILDKL--MEHPIAAP-FLEPVDPDEYP--DYYSVIKKPMDLSTIKKKLENGEYKSLAEFLADVKLIFSNARTYNGPG 75


                  ....*...
gi 1622831293 356 HEVVTMAR 363
Cdd:pfam00439  76 SVIYKAAE 83
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 13-136 3.92e-17

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 84.47  E-value: 3.92e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293  13 NPPPPEYINTKKNgrltNQLQYLQKVVLKDLWKHSFSWPFQRPVDavKLKLPDYYTIIKNPMDLNTIKKRLENKYYVKAS 92
Cdd:COG5076   134 KTPKIEDELLYAD----NKAIAKFKKQLFLRDGRFLSSIFLGLPS--KREYPDYYEIIKSPMDLLTIQKKLKNGRYKSFE 207

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1622831293  93 ECIEDFNTMFSNCYLYNKPGDDIVLMAQALEKLFMQKLSQMPQE 136
Cdd:COG5076   208 EFVSDLNLMFDNCKLYNGPDSSVYVDAKELEKYFLKLIEEIPEE 251
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 274-385 4.97e-17

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 84.09  E-value: 4.97e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293 274 RHCSEILKEML---AKKHFSYAWPFYNPVDVNALGlhNYYDIVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYK 350
Cdd:COG5076   145 ADNKAIAKFKKqlfLRDGRFLSSIFLGLPSKREYP--DYYEIIKSPMDLLTIQKKLKNGRYKSFEEFVSDLNLMFDNCKL 222

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1622831293 351 YNPPDHEVVTMARMLQDVFETHFSKIPVEPVESMP 385
Cdd:COG5076   223 YNGPDSSVYVDAKELEKYFLKLIEEIPEEMLELSI 257
BRD4_CDT pfam17105
C-terminal domain of bromodomain protein 4; BRD4_CDT is the short highly conserved C-terminal ...
 905-947 2.58e-10

C-terminal domain of bromodomain protein 4; BRD4_CDT is the short highly conserved C-terminal domain of certain bromodomain proteins, notably Brd4. The Brd4 CTD interacts with the cyclin T1 and Cdk9 subunits of positive transcription elongation factor b (pTEFb) complex. Brd4 displaces negative regulators, the HEXIM1 and 7SKsnRNA complex, from pTEFb, thereby transforming it into an active form that can phosphorylate RNA pol II.


Pssm-ID: 465349  Cd Length: 44  Bit Score: 56.25  E-value: 2.58e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1622831293 905 WLLKDRNLAREKEQERRRREAMAGTIDMTLQSDIMTMFENNFD 947
Cdd:pfam17105   2 SLDKERELARKREQERRRREAMAGTIDMNLQSDIMASFEENLD 44
 
Name Accession Description Interval E-value
Bromo_Brdt_I_like cd05497
Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET ...
 27-133 2.60e-70

Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99929  Cd Length: 107  Bit Score: 228.07  E-value: 2.60e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293  27 RLTNQLQYLQKVVLKDLWKHSFSWPFQRPVDAVKLKLPDYYTIIKNPMDLNTIKKRLENKYYVKASECIEDFNTMFSNCY 106
Cdd:cd05497     1 RHTNQLQYLLKVVLKALWKHKFAWPFQQPVDAVKLNLPDYHKIIKTPMDLGTIKKRLENNYYWSASECIQDFNTMFTNCY 80

                          90       100
                  ....*....|....*....|....*..
gi 1622831293 107 LYNKPGDDIVLMAQALEKLFMQKLSQM 133
Cdd:cd05497    81 IYNKPGDDVVLMAQTLEKLFLQKLAQM 107
Bromo_Brdt_II_like cd05498
Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET ...
 272-373 1.55e-60

Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99930  Cd Length: 102  Bit Score: 200.97  E-value: 1.55e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293 272 QLRHCSEILKEMLAKKHFSYAWPFYNPVDVNALGLHNYYDIVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKY 351
Cdd:cd05498     1 QLKFCSGILKELFSKKHKAYAWPFYKPVDPEALGLHDYHDIIKHPMDLSTIKKKLDNREYADAQEFAADVRLMFSNCYKY 80

                          90       100
                  ....*....|....*....|..
gi 1622831293 352 NPPDHEVVTMARMLQDVFETHF 373
Cdd:cd05498    81 NPPDHPVHAMARKLQDVFEDRW 102
Bromo_BDF1_2_II cd05499
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast ...
 273-372 1.03e-36

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99931  Cd Length: 102  Bit Score: 133.56  E-value: 1.03e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293 273 LRHCSEILKEMLAKKHFSYAWPFYNPVDVNALGLHNYYDIVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYN 352
Cdd:cd05499     2 LKFCEEVLKELMKPKHSAYNWPFLDPVDPVALNIPNYFSIIKKPMDLGTISKKLQNGQYQSAKEFERDVRLIFKNCYTFN 81

                          90       100
                  ....*....|....*....|
gi 1622831293 353 PPDHEVVTMARMLQDVFETH 372
Cdd:cd05499    82 PEGTDVYMMGHQLEEVFNDK 101
Bromo_plant1 cd05506
Bromodomain, uncharacterized subfamily specific to plants. Might function as a global ...
 273-371 7.40e-36

Bromodomain, uncharacterized subfamily specific to plants. Might function as a global transcription factor. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99938  Cd Length: 99  Bit Score: 130.91  E-value: 7.40e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293 273 LRHCSEILKEMLAKKHfsyAWPFYNPVDVNALGLHNYYDIVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYN 352
Cdd:cd05506     2 MKQCGTLLRKLMKHKW---GWVFNAPVDVVALGLPDYFDIIKKPMDLGTVKKKLEKGEYSSPEEFAADVRLTFANAMRYN 78

                          90
                  ....*....|....*....
gi 1622831293 353 PPDHEVVTMARMLQDVFET 371
Cdd:cd05506    79 PPGNDVHTMAKELLKIFET 97
Bromo_Brdt_II_like cd05498
Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET ...
 31-129 4.77e-34

Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99930  Cd Length: 102  Bit Score: 125.85  E-value: 4.77e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293  31 QLQYLQKVvLKDLW--KH-SFSWPFQRPVDAVKLKLPDYYTIIKNPMDLNTIKKRLENKYYVKASECIEDFNTMFSNCYL 107
Cdd:cd05498     1 QLKFCSGI-LKELFskKHkAYAWPFYKPVDPEALGLHDYHDIIKHPMDLSTIKKKLDNREYADAQEFAADVRLMFSNCYK 79

                          90       100
                  ....*....|....*....|..
gi 1622831293 108 YNKPGDDIVLMAQALEKLFMQK 129
Cdd:cd05498    80 YNPPDHPVHAMARKLQDVFEDR 101
BROMO smart00297
bromo domain;
271-376 8.76e-34

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 125.47  E-value: 8.76e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293  271 EQLRHCSEILKEMLAKKHFS-YAWPFYNPVDVNALglHNYYDIVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCY 349
Cdd:smart00297   3 KLQKKLQELLKAVLDKLDSHpLSWPFLKPVSRKEA--PDYYDIIKKPMDLKTIKKKLENGKYSSVEEFVADFNLMFSNAR 80

                           90       100
                   ....*....|....*....|....*..
gi 1622831293  350 KYNPPDHEVVTMARMLQDVFETHFSKI 376
Cdd:smart00297  81 TYNGPDSEVYKDAKKLEKFFEKKLREL 107
Bromo_gcn5_like cd05509
Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates ...
 31-130 3.95e-33

Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99941 [Multi-domain]  Cd Length: 101  Bit Score: 123.05  E-value: 3.95e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293  31 QLQYLQKVVLKDLWKHSFSWPFQRPVDavKLKLPDYYTIIKNPMDLNTIKKRLENKYYVKASECIEDFNTMFSNCYLYNK 110
Cdd:cd05509     1 PLYTQLKKVLDSLKNHKSAWPFLEPVD--KEEAPDYYDVIKKPMDLSTMEEKLENGYYVTLEEFVADLKLIFDNCRLYNG 78

                          90       100
                  ....*....|....*....|
gi 1622831293 111 PGDDIVLMAQALEKLFMQKL 130
Cdd:cd05509    79 PDTEYYKCANKLEKFFWKKL 98
BROMO smart00297
bromo domain;
27-133 6.41e-33

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 122.77  E-value: 6.41e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293   27 RLTNQLQYLQKVVLKDLWKHSFSWPFQRPVDAVKLklPDYYTIIKNPMDLNTIKKRLENKYYVKASECIEDFNTMFSNCY 106
Cdd:smart00297   3 KLQKKLQELLKAVLDKLDSHPLSWPFLKPVSRKEA--PDYYDIIKKPMDLKTIKKKLENGKYSSVEEFVADFNLMFSNAR 80

                           90       100
                   ....*....|....*....|....*..
gi 1622831293  107 LYNKPGDDIVLMAQALEKLFMQKLSQM 133
Cdd:smart00297  81 TYNGPDSEVYKDAKKLEKFFEKKLREL 107
Bromo_plant1 cd05506
Bromodomain, uncharacterized subfamily specific to plants. Might function as a global ...
 40-126 1.06e-30

Bromodomain, uncharacterized subfamily specific to plants. Might function as a global transcription factor. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99938  Cd Length: 99  Bit Score: 116.28  E-value: 1.06e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293  40 LKDLWKHSFSWPFQRPVDAVKLKLPDYYTIIKNPMDLNTIKKRLENKYYVKASECIEDFNTMFSNCYLYNKPGDDIVLMA 119
Cdd:cd05506     9 LRKLMKHKWGWVFNAPVDVVALGLPDYFDIIKKPMDLGTVKKKLEKGEYSSPEEFAADVRLTFANAMRYNPPGNDVHTMA 88


                  ....*..
gi 1622831293 120 QALEKLF 126
Cdd:cd05506    89 KELLKIF 95
Bromodomain cd04369
Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear ...
 37-130 1.09e-28

Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99922 [Multi-domain]  Cd Length: 99  Bit Score: 110.54  E-value: 1.09e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293  37 KVVLKDLWKH--SFSWPFQRPVDavKLKLPDYYTIIKNPMDLNTIKKRLENKYYVKASECIEDFNTMFSNCYLYNKPGDD 114
Cdd:cd04369     6 RSLLDALKKLkrDLSEPFLEPVD--PKEAPDYYEVIKNPMDLSTIKKKLKNGEYKSLEEFEADVRLIFSNAKTYNGPGSP 83

                          90
                  ....*....|....*.
gi 1622831293 115 IVLMAQALEKLFMQKL 130
Cdd:cd04369    84 IYKDAKKLEKLFEKLL 99
Bromodomain cd04369
Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear ...
 276-373 1.52e-28

Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99922 [Multi-domain]  Cd Length: 99  Bit Score: 110.15  E-value: 1.52e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293 276 CSEILKEMLaKKHFSYAWPFYNPVDvnALGLHNYYDIVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPD 355
Cdd:cd04369     5 LRSLLDALK-KLKRDLSEPFLEPVD--PKEAPDYYEVIKNPMDLSTIKKKLKNGEYKSLEEFEADVRLIFSNAKTYNGPG 81

                          90
                  ....*....|....*...
gi 1622831293 356 HEVVTMARMLQDVFETHF 373
Cdd:cd04369    82 SPIYKDAKKLEKLFEKLL 99
Bromo_gcn5_like cd05509
Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates ...
 268-371 1.39e-26

Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99941 [Multi-domain]  Cd Length: 101  Bit Score: 104.56  E-value: 1.39e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293 268 KVTEQLRHcseILKEMlaKKHfSYAWPFYNPVDVNALglHNYYDIVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMN 347
Cdd:cd05509     1 PLYTQLKK---VLDSL--KNH-KSAWPFLEPVDKEEA--PDYYDVIKKPMDLSTMEEKLENGYYVTLEEFVADLKLIFDN 72

                          90       100
                  ....*....|....*....|....
gi 1622831293 348 CYKYNPPDHEVVTMARMLQDVFET 371
Cdd:cd05509    73 CRLYNGPDTEYYKCANKLEKFFWK 96
Bromo_BDF1_2_II cd05499
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast ...
 39-130 3.35e-26

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99931  Cd Length: 102  Bit Score: 103.52  E-value: 3.35e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293  39 VLKDLWK---HSFSWPFQRPVDAVKLKLPDYYTIIKNPMDLNTIKKRLENKYYVKASECIEDFNTMFSNCYLYNKPGDDI 115
Cdd:cd05499     8 VLKELMKpkhSAYNWPFLDPVDPVALNIPNYFSIIKKPMDLGTISKKLQNGQYQSAKEFERDVRLIFKNCYTFNPEGTDV 87

                          90
                  ....*....|....*
gi 1622831293 116 VLMAQALEKLFMQKL 130
Cdd:cd05499    88 YMMGHQLEEVFNDKW 102
Bromo_Brdt_I_like cd05497
Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET ...
 268-369 6.46e-26

Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99929  Cd Length: 107  Bit Score: 102.89  E-value: 6.46e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293 268 KVTEQLRHCSEILKEMLAKKHFsyAWPFYNPVDVNALGLHNYYDIVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMN 347
Cdd:cd05497     1 RHTNQLQYLLKVVLKALWKHKF--AWPFQQPVDAVKLNLPDYHKIIKTPMDLGTIKKRLENNYYWSASECIQDFNTMFTN 78

                          90       100
                  ....*....|....*....|..
gi 1622831293 348 CYKYNPPDHEVVTMARMLQDVF 369
Cdd:cd05497    79 CYIYNKPGDDVVLMAQTLEKLF 100
Bromo_BDF1_2_I cd05500
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast ...
 271-372 4.32e-24

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99932  Cd Length: 103  Bit Score: 97.38  E-value: 4.32e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293 271 EQLRHCSEILKemlAKKHFSYAWPFYNPVDVNALGLHNYYDIVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYK 350
Cdd:cd05500     4 HQHKFLLSSIR---SLKRLKDARPFLVPVDPVKLNIPHYPTIIKKPMDLGTIERKLKSNVYTSVEEFTADFNLMVDNCLT 80

                          90       100
                  ....*....|....*....|..
gi 1622831293 351 YNPPDHEVVTMARMLQDVFETH 372
Cdd:cd05500    81 FNGPEHPVSQMGKRLQAAFEKH 102
BET pfam17035
Bromodomain extra-terminal - transcription regulation; The BET, or bromodomain extra-terminal ...
 509-571 8.21e-24

Bromodomain extra-terminal - transcription regulation; The BET, or bromodomain extra-terminal domain, is found on bromodomain proteins that play key roles in development, cancer progression and virus-host pathogenesis. It interacts with NSD3, JMJD6, CHD4, GLTSCR1, and ATAD5 all of which are shown to impart a pTEFb-independent transcriptional activation function on the bromodomain proteins.


Pssm-ID: 435704  Cd Length: 64  Bit Score: 95.25  E-value: 8.21e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622831293 509 PMNYDEKRQLSLNINKLPGDKLGRVVHIIQSREPSLsNSNPDEIEIDFETLKASTLRELEKYV 571
Cdd:pfam17035   1 PMTYEEKRELSERINKLPGEKLGRVIEIIKERNPEL-QSDDDEIELDIDALDDDTLRKLYNFV 62
Bromo_BDF1_2_I cd05500
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast ...
 31-130 2.63e-22

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99932  Cd Length: 103  Bit Score: 92.38  E-value: 2.63e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293  31 QLQYLQKVvLKDLWKHSFSWPFQRPVDAVKLKLPDYYTIIKNPMDLNTIKKRLENKYYVKASECIEDFNTMFSNCYLYNK 110
Cdd:cd05500     5 QHKFLLSS-IRSLKRLKDARPFLVPVDPVKLNIPHYPTIIKKPMDLGTIERKLKSNVYTSVEEFTADFNLMVDNCLTFNG 83

                          90       100
                  ....*....|....*....|
gi 1622831293 111 PGDDIVLMAQALEKLFMQKL 130
Cdd:cd05500    84 PEHPVSQMGKRLQAAFEKHL 103
Bromo_Acf1_like cd05504
Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was ...
 39-133 4.08e-22

Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) and regulates ISWI-induced nucleosome remodeling. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99936  Cd Length: 115  Bit Score: 92.46  E-value: 4.08e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293  39 VLKDLWKHSFSWPFQRPVDavKLKLPDYYTIIKNPMDLNTIKKRLENKYYVKASECIEDFNTMFSNCYLYNKPGDDIVLM 118
Cdd:cd05504    20 LLVEIVKHKDSWPFLRPVS--KIEVPDYYDIIKKPMDLGTIKEKLNMGEYKLAEEFLSDIQLVFSNCFLYNPEHTSVYKA 97

                          90
                  ....*....|....*
gi 1622831293 119 AQALEKLFMQKLSQM 133
Cdd:cd05504    98 GTRLQRFFIKRCRKL 112
Bromo_cbp_like cd05495
Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase ...
 271-370 3.31e-21

Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to phosphorylated CREB protein and augments the activity of phosphorylated CREB to activate transcription of cAMP-responsive genes. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99927  Cd Length: 108  Bit Score: 89.42  E-value: 3.31e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293 271 EQLRHCSEILKEMLakKHFSYAWPFYNPVDVNALGLHNYYDIVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYK 350
Cdd:cd05495     3 ELRQALMPTLEKLY--KQDPESLPFRQPVDPKLLGIPDYFDIVKNPMDLSTIRRKLDTGQYQDPWQYVDDVWLMFDNAWL 80

                          90       100
                  ....*....|....*....|
gi 1622831293 351 YNPPDHEVVTMARMLQDVFE 370
Cdd:cd05495    81 YNRKTSRVYKYCTKLAEVFE 100
Bromo_tif1_like cd05502
Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of ...
 273-376 7.63e-21

Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or corepressors to modulate transcription. Vertebrate Tif1-gamma, also labeled E3 ubiquitin-protein ligase TRIM33, plays a role in the control of hematopoiesis. Its homologue in Xenopus laevis, Ectodermin, has been shown to function in germ-layer specification and control of cell growth during embryogenesis. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99934 [Multi-domain]  Cd Length: 109  Bit Score: 88.50  E-value: 7.63e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293 273 LRHCSEILKEMLAKkhfSYAWPFYNPVDVNAlglHNYYDIVKNPMDLGTIKEKMD---NQEYKDAYKFAADVRLMFMNCY 349
Cdd:cd05502     6 QRKCERLLLELYCH---ELSLPFHEPVSPSV---PNYYKIIKTPMDLSLIRKKLQpksPQHYSSPEEFVADVRLMFKNCY 79

                          90       100
                  ....*....|....*....|....*..
gi 1622831293 350 KYNPPDHEVVTMARMLQDVFETHFSKI 376
Cdd:cd05502    80 KFNEEDSEVAQAGKELELFFEEQLKEI 106
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 39-120 1.78e-20

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 86.60  E-value: 1.78e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293  39 VLKDLWKHSFSWPFQRPVDAVKLklPDYYTIIKNPMDLNTIKKRLENKYYVKASECIEDFNTMFSNCYLYNKPGDDIVLM 118
Cdd:pfam00439   4 ILDKLMEHPIAAPFLEPVDPDEY--PDYYSVIKKPMDLSTIKKKLENGEYKSLAEFLADVKLIFSNARTYNGPGSVIYKA 81


                  ..
gi 1622831293 119 AQ 120
Cdd:pfam00439  82 AE 83
Bromo_Acf1_like cd05504
Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was ...
 271-371 3.55e-20

Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) and regulates ISWI-induced nucleosome remodeling. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99936  Cd Length: 115  Bit Score: 86.68  E-value: 3.55e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293 271 EQLRHCSEILKEMLA--KKHfSYAWPFYNPVDVNALGlhNYYDIVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNC 348
Cdd:cd05504     8 HHGPLNLSALEQLLVeiVKH-KDSWPFLRPVSKIEVP--DYYDIIKKPMDLGTIKEKLNMGEYKLAEEFLSDIQLVFSNC 84

                          90       100
                  ....*....|....*....|...
gi 1622831293 349 YKYNPPDHEVVTMARMLQDVFET 371
Cdd:cd05504    85 FLYNPEHTSVYKAGTRLQRFFIK 107
Bromo_cbp_like cd05495
Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase ...
 32-135 4.57e-20

Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to phosphorylated CREB protein and augments the activity of phosphorylated CREB to activate transcription of cAMP-responsive genes. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99927  Cd Length: 108  Bit Score: 86.34  E-value: 4.57e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293  32 LQYLQKVVLKDLWKHSFSWPFQRPVDAVKLKLPDYYTIIKNPMDLNTIKKRLENKYYVKASECIEDFNTMFSNCYLYNKP 111
Cdd:cd05495     5 RQALMPTLEKLYKQDPESLPFRQPVDPKLLGIPDYFDIVKNPMDLSTIRRKLDTGQYQDPWQYVDDVWLMFDNAWLYNRK 84

                          90       100
                  ....*....|....*....|....
gi 1622831293 112 GDDIVLMAQALEKLFMQKLSQMPQ 135
Cdd:cd05495    85 TSRVYKYCTKLAEVFEQEIDPVMQ 108
Bromo_tif1_like cd05502
Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of ...
 32-132 1.19e-19

Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or corepressors to modulate transcription. Vertebrate Tif1-gamma, also labeled E3 ubiquitin-protein ligase TRIM33, plays a role in the control of hematopoiesis. Its homologue in Xenopus laevis, Ectodermin, has been shown to function in germ-layer specification and control of cell growth during embryogenesis. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99934 [Multi-domain]  Cd Length: 109  Bit Score: 85.04  E-value: 1.19e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293  32 LQYLQKVVLKdLWKHSFSWPFQRPVdavKLKLPDYYTIIKNPMDLNTIKKRLENK---YYVKASECIEDFNTMFSNCYLY 108
Cdd:cd05502     6 QRKCERLLLE-LYCHELSLPFHEPV---SPSVPNYYKIIKTPMDLSLIRKKLQPKspqHYSSPEEFVADVRLMFKNCYKF 81

                          90       100
                  ....*....|....*....|....
gi 1622831293 109 NKPGDDIVLMAQALEKLFMQKLSQ 132
Cdd:cd05502    82 NEEDSEVAQAGKELELFFEEQLKE 105
Bromo_BAZ2A_B_like cd05503
Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B ...
 37-129 3.64e-19

Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting protein 5) and hWALp3. The proteins may play roles in transcriptional regulation. Human Tip5 is part of a complex termed NoRC (nucleolar remodeling complex), which induces nucleosome sliding and may play a role in the regulation of the rDNA locus. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99935  Cd Length: 97  Bit Score: 83.19  E-value: 3.64e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293  37 KVVLKDLWKHSFSWPFQRPVDAvKLkLPDYYTIIKNPMDLNTIKKRLENKYYVKASECIEDFNTMFSNCYLYNKPGDDIV 116
Cdd:cd05503     6 ETILDEMEAHEDAWPFLEPVNT-KL-VPGYRKIIKKPMDFSTIREKLESGQYKTLEEFAEDVRLVFDNCETFNEDDSEVG 83

                          90
                  ....*....|...
gi 1622831293 117 LMAQALEKLFMQK 129
Cdd:cd05503    84 RAGHNMRKFFEKR 96
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 276-363 3.66e-18

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 80.05  E-value: 3.66e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293 276 CSEILKEMlaKKHFSYAWpFYNPVDVNALGlhNYYDIVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPD 355
Cdd:pfam00439   1 CLEILDKL--MEHPIAAP-FLEPVDPDEYP--DYYSVIKKPMDLSTIKKKLENGEYKSLAEFLADVKLIFSNARTYNGPG 75


                  ....*...
gi 1622831293 356 HEVVTMAR 363
Cdd:pfam00439  76 SVIYKAAE 83
Bromo_BAZ2A_B_like cd05503
Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B ...
 276-371 3.56e-17

Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting protein 5) and hWALp3. The proteins may play roles in transcriptional regulation. Human Tip5 is part of a complex termed NoRC (nucleolar remodeling complex), which induces nucleosome sliding and may play a role in the regulation of the rDNA locus. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99935  Cd Length: 97  Bit Score: 77.41  E-value: 3.56e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293 276 CSEILKEMLAKKHfsyAWPFYNPVdvNALGLHNYYDIVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPD 355
Cdd:cd05503     5 CETILDEMEAHED---AWPFLEPV--NTKLVPGYRKIIKKPMDFSTIREKLESGQYKTLEEFAEDVRLVFDNCETFNEDD 79

                          90
                  ....*....|....*.
gi 1622831293 356 HEVVTMARMLQDVFET 371
Cdd:cd05503    80 SEVGRAGHNMRKFFEK 95
Bromo_SPT7_like cd05510
Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the ...
 276-377 3.76e-17

Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA, and SLIK. SAGA is involved in the RNA polymerase II-dependent transcriptional regulation of about 10% of all yeast genes. The SPT7 bromodomain has been shown to weakly interact with acetylated histone H3, but not H4. The human representative of this subfamily is cat eye syndrome critical region protein 2 (CECR2). Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99942 [Multi-domain]  Cd Length: 112  Bit Score: 77.87  E-value: 3.76e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293 276 CSEILKEMlaKKHFSYAWPFYNPVdvNALGLHNYYDIVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNP-P 354
Cdd:cd05510    12 LDKVLNEL--KTYTEHSTPFLTKV--SKREAPDYYDIIKKPMDLGTMLKKLKNLQYKSKAEFVDDLNLIWKNCLLYNSdP 87

                          90       100
                  ....*....|....*....|...
gi 1622831293 355 DHEVVTMARMLQDVFETHFSKIP 377
Cdd:cd05510    88 SHPLRRHANFMKKKAEHLLKLIP 110
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 13-136 3.92e-17

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 84.47  E-value: 3.92e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293  13 NPPPPEYINTKKNgrltNQLQYLQKVVLKDLWKHSFSWPFQRPVDavKLKLPDYYTIIKNPMDLNTIKKRLENKYYVKAS 92
Cdd:COG5076   134 KTPKIEDELLYAD----NKAIAKFKKQLFLRDGRFLSSIFLGLPS--KREYPDYYEIIKSPMDLLTIQKKLKNGRYKSFE 207

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1622831293  93 ECIEDFNTMFSNCYLYNKPGDDIVLMAQALEKLFMQKLSQMPQE 136
Cdd:COG5076   208 EFVSDLNLMFDNCKLYNGPDSSVYVDAKELEKYFLKLIEEIPEE 251
Bromo_SNF2 cd05519
Bromodomain, SNF2-like subfamily, specific to fungi. SNF2 is a yeast protein involved in ...
 64-129 4.44e-17

Bromodomain, SNF2-like subfamily, specific to fungi. SNF2 is a yeast protein involved in transcriptional activation, it is the catalytic component of the SWI/SNF ATP-dependent chromatin remodeling complex. The protein is essential for the regulation of gene expression (both positive and negative) of a large number of genes. The SWI/SNF complex changes chromatin structure by altering DNA-histone contacts within the nucleosome, which results in a re-positioning of the nucleosome and facilitates or represses the binding of gene-specific transcription factors. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99950  Cd Length: 103  Bit Score: 77.38  E-value: 4.44e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622831293  64 PDYYTIIKNPMDLNTIKKRLENKYYVKASECIEDFNTMFSNCYLYNKPGDDIVLMAQALEKLFMQK 129
Cdd:cd05519    37 PDYYVIIKRPIALDQIKRRIEGRAYKSLEEFLEDFHLMFANARTYNQEGSIVYEDAVEMEKAFKKK 102
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 274-385 4.97e-17

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 84.09  E-value: 4.97e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293 274 RHCSEILKEML---AKKHFSYAWPFYNPVDVNALGlhNYYDIVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYK 350
Cdd:COG5076   145 ADNKAIAKFKKqlfLRDGRFLSSIFLGLPSKREYP--DYYEIIKSPMDLLTIQKKLKNGRYKSFEEFVSDLNLMFDNCKL 222

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1622831293 351 YNPPDHEVVTMARMLQDVFETHFSKIPVEPVESMP 385
Cdd:COG5076   223 YNGPDSSVYVDAKELEKYFLKLIEEIPEEMLELSI 257
Bromo_SPT7_like cd05510
Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the ...
 35-124 9.74e-17

Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA, and SLIK. SAGA is involved in the RNA polymerase II-dependent transcriptional regulation of about 10% of all yeast genes. The SPT7 bromodomain has been shown to weakly interact with acetylated histone H3, but not H4. The human representative of this subfamily is cat eye syndrome critical region protein 2 (CECR2). Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99942 [Multi-domain]  Cd Length: 112  Bit Score: 76.71  E-value: 9.74e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293  35 LQKVV--LKDLWKHSFswPFQRPVDavKLKLPDYYTIIKNPMDLNTIKKRLENKYYVKASECIEDFNTMFSNCYLYNK-P 111
Cdd:cd05510    12 LDKVLneLKTYTEHST--PFLTKVS--KREAPDYYDIIKKPMDLGTMLKKLKNLQYKSKAEFVDDLNLIWKNCLLYNSdP 87

                          90
                  ....*....|...
gi 1622831293 112 GDDIVLMAQALEK 124
Cdd:cd05510    88 SHPLRRHANFMKK 100
Bromo_polybromo_V cd05515
Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which ...
 60-132 1.53e-16

Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99946  Cd Length: 105  Bit Score: 76.19  E-value: 1.53e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622831293  60 KLKLPDYYTIIKNPMDLNTIKKRLENKYYVKASECIEDFNTMFSNCYLYNKPGDDIVLMAQALEKLFMQKLSQ 132
Cdd:cd05515    33 KSEYPDYYDVIKKPIDMEKIRSKIEGNQYQSLDDMVSDFVLMFDNACKYNEPDSQIYKDALTLQKVLLETKRE 105
Bromo_TFIID cd05511
Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, ...
 49-136 4.55e-16

Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to acetylated histone H4. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99943 [Multi-domain]  Cd Length: 112  Bit Score: 74.99  E-value: 4.55e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293  49 SWPFQRPVDavKLKLPDYYTIIKNPMDLNTIKKRLENKYYVKASECIEDFNTMFSNCYLYNKPGDDIVLMAQALEKLFMQ 128
Cdd:cd05511    18 SWPFHTPVN--KKKVPDYYKIIKRPMDLQTIRKKISKHKYQSREEFLEDIELIVDNSVLYNGPDSVYTKKAKEMLELAEE 95


                  ....*...
gi 1622831293 129 KLSQMPQE 136
Cdd:cd05511    96 LLAEREEK 103
Bromo_TFIID cd05511
Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, ...
 277-375 6.09e-16

Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to acetylated histone H4. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99943 [Multi-domain]  Cd Length: 112  Bit Score: 74.61  E-value: 6.09e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293 277 SEILKEMLAK-KHFSYAWPFYNPVdvNALGLHNYYDIVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPD 355
Cdd:cd05511     2 SFILDEIVNElKNLPDSWPFHTPV--NKKKVPDYYKIIKRPMDLQTIRKKISKHKYQSREEFLEDIELIVDNSVLYNGPD 79

                          90       100
                  ....*....|....*....|....*..
gi 1622831293 356 H-------EVVTMARMLQDVFETHFSK 375
Cdd:cd05511    80 SvytkkakEMLELAEELLAEREEKLTQ 106
Bromo_WDR9_I_like cd05529
Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 27-133 2.55e-15

Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99958  Cd Length: 128  Bit Score: 73.53  E-value: 2.55e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293  27 RLTNQLQYLQKVVLKDLWKhsfswPFQRPVDaVKLKLPDYYTIIKNPMDLNTIKKRLENKYYVKASECIEDFNTMFSNCY 106
Cdd:cd05529    28 RLISGLDKLLLSLQLEIAE-----YFEYPVD-LRAWYPDYWNRVPVPMDLETIRSRLENRYYRSLEALRHDVRLILSNAE 101

                          90       100
                  ....*....|....*....|....*..
gi 1622831293 107 LYNKPGDDIVLMAQALEKLFMQKLSQM 133
Cdd:cd05529   102 TFNEPNSEIAKKAKRLSDWLLRILSSL 128
Bromo_WDR9_II cd05496
Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 276-376 1.82e-14

Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99928  Cd Length: 119  Bit Score: 70.56  E-value: 1.82e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293 276 CSEILKEMLAKkhfSYAWPFYNPVDVnaLGLHNYYDIVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNP-P 354
Cdd:cd05496    10 CKELVNLMWDC---EDSEPFRQPVDL--LKYPDYRDIIDTPMDLGTVKETLFGGNYDDPMEFAKDVRLIFSNSKSYTPnK 84

                          90       100
                  ....*....|....*....|..
gi 1622831293 355 DHEVVTMARMLQDVFETHFSKI 376
Cdd:cd05496    85 RSRIYSMTLRLSALFEEHIKKI 106
Bromo_WSTF_like cd05505
Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The ...
 39-116 8.11e-14

Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The Williams-Beuren syndrome deletion transcript 9 is a putative transcriptional regulator. WSTF was found to play a role in vitamin D-mediated transcription as part of two chromatin remodeling complexes, WINAC and WICH. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99937  Cd Length: 97  Bit Score: 67.95  E-value: 8.11e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622831293  39 VLKDLWKHSFSWPFQRPVDAVKLklPDYYTIIKNPMDLNTIKKRLENKYYVKASECIEDFNTMFSNCYLYNKPGDDIV 116
Cdd:cd05505     8 ILSKILKYRFSWPFREPVTADEA--EDYKKVITNPMDLQTMQTKCSCGSYSSVQEFLDDMKLVFSNAEKYYENGSYVL 83
Bromo_polybromo_IV cd05518
Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which ...
 64-130 9.07e-14

Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99949 [Multi-domain]  Cd Length: 103  Bit Score: 68.24  E-value: 9.07e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622831293  64 PDYYTIIKNPMDLNTIKKRLENKYYVKASECIEDFNTMFSNCYLYNKPGDDIVLMAQALEKLFMQKL 130
Cdd:cd05518    37 PDYYKIILEPIDLKTIEHNIRNDKYATEEELMDDFKLMFRNARHYNEEGSQVYEDANILEKVLKEKR 103
Bromo_brd8_like cd05507
Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with ...
 291-367 4.54e-13

Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be a nuclear receptor coactivator. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99939  Cd Length: 104  Bit Score: 66.23  E-value: 4.54e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622831293 291 YAWPFYNPV-DVNALGlhnYYDIVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPDHEVVTMARMLQD 367
Cdd:cd05507    20 YASVFLKPVtEDIAPG---YHSVVYRPMDLSTIKKNIENGTIRSTAEFQRDVLLMFQNAIMYNSSDHDVYLMAVEMQR 94
Bromo_AAA cd05528
Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long ...
 272-368 6.80e-13

Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this alignment is an uncharacterized protein predicted from analysis of cDNA clones from human fetal liver


Pssm-ID: 99957  Cd Length: 112  Bit Score: 65.84  E-value: 6.80e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293 272 QLRHC-SEILKEMLAKKHFSyawPFYNPVDVNALglHNYYDIVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYK 350
Cdd:cd05528     3 ELRLFlRDVLKRLASDKRFN---AFTKPVDEEEV--PDYYEIIKQPMDLQTILQKLDTHQYLTAKDFLKDIDLIVTNALE 77

                          90       100
                  ....*....|....*....|..
gi 1622831293 351 YNP----PDHEVVTMARMLQDV 368
Cdd:cd05528    78 YNPdrdpADKLIRSRACELRDE 99
Bromo_WSTF_like cd05505
Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The ...
 272-369 6.91e-13

Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The Williams-Beuren syndrome deletion transcript 9 is a putative transcriptional regulator. WSTF was found to play a role in vitamin D-mediated transcription as part of two chromatin remodeling complexes, WINAC and WICH. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99937  Cd Length: 97  Bit Score: 65.25  E-value: 6.91e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293 272 QLRHCSEILKEMLakkHFSYAWPFYNPVdvNALGLHNYYDIVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKY 351
Cdd:cd05505     1 ELQKCEEILSKIL---KYRFSWPFREPV--TADEAEDYKKVITNPMDLQTMQTKCSCGSYSSVQEFLDDMKLVFSNAEKY 75

                          90
                  ....*....|....*...
gi 1622831293 352 NPPDHEVVTMARMLQDVF 369
Cdd:cd05505    76 YENGSYVLSCMRKTEQCC 93
Bromo_Rsc1_2_II cd05522
Bromodomain, repeat II in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are ...
 27-127 9.49e-13

Bromodomain, repeat II in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two bromodomains. The RSC complex has also been linked to homologous recombination and nonhomologous end-joining repair of DNA double strand breaks. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99953 [Multi-domain]  Cd Length: 104  Bit Score: 65.34  E-value: 9.49e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293  27 RLTNQLQYLQKVVLKDlwKHSFSWPFQRPVDavKLKLPDYYTIIKNPMDLNTIKKRLENKYYVKASECIEDFNTMFSNCY 106
Cdd:cd05522     5 RIKNILKGLRKERDEN--GRLLTLHFEKLPD--KAREPEYYQEISNPISLDDIKKKVKRRKYKSFDQFLNDLNLMFENAK 80

                          90       100
                  ....*....|....*....|.
gi 1622831293 107 LYNKPGDDIVLMAQALEKLFM 127
Cdd:cd05522    81 LYNENDSQEYKDAVLLEKEAR 101
Bromo_brd8_like cd05507
Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with ...
 39-138 3.54e-12

Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be a nuclear receptor coactivator. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99939  Cd Length: 104  Bit Score: 63.54  E-value: 3.54e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293  39 VLKDLWKHSFSWPFQRPVDavKLKLPDYYTIIKNPMDLNTIKKRLENKYYVKASECIEDFNTMFSNCYLYNKPGDDIVLM 118
Cdd:cd05507    11 VYRTLASHRYASVFLKPVT--EDIAPGYHSVVYRPMDLSTIKKNIENGTIRSTAEFQRDVLLMFQNAIMYNSSDHDVYLM 88

                          90       100
                  ....*....|....*....|
gi 1622831293 119 AqalekLFMQKlSQMPQEEQ 138
Cdd:cd05507    89 A-----VEMQR-EVMSQIQQ 102
Bromo_SNF2L2 cd05516
Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI ...
 27-126 7.53e-12

Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone receptors to boost transcriptional activation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99947  Cd Length: 107  Bit Score: 62.83  E-value: 7.53e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293  27 RLTNQLQYLQKVVLK--DLWKHSFSWPFQR-PVdavKLKLPDYYTIIKNPMDLNTIKKRLENKYYVKASECIEDFNTMFS 103
Cdd:cd05516     1 ELTKKMNKIVDVVIKykDSDGRQLAEVFIQlPS---RKELPEYYELIRKPVDFKKIKERIRNHKYRSLEDLEKDVMLLCQ 77

                          90       100
                  ....*....|....*....|...
gi 1622831293 104 NCYLYNKPGDDIVLMAQALEKLF 126
Cdd:cd05516    78 NAQTFNLEGSLIYEDSIVLQSVF 100
Bromo_polybromo_V cd05515
Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which ...
 309-369 9.63e-12

Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99946  Cd Length: 105  Bit Score: 62.32  E-value: 9.63e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622831293 309 YYDIVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPDHEVVTMARMLQDVF 369
Cdd:cd05515    39 YYDVIKKPIDMEKIRSKIEGNQYQSLDDMVSDFVLMFDNACKYNEPDSQIYKDALTLQKVL 99
Bromo_WDR9_I_like cd05529
Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 280-369 1.33e-11

Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99958  Cd Length: 128  Bit Score: 62.74  E-value: 1.33e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293 280 LKEMLAKKHFSYAWPFYNPVDVNALgLHNYYDIVKNPMDLGTIKEKMDNQEY--KDAYKFaaDVRLMFMNCYKYNPPDHE 357
Cdd:cd05529    33 LDKLLLSLQLEIAEYFEYPVDLRAW-YPDYWNRVPVPMDLETIRSRLENRYYrsLEALRH--DVRLILSNAETFNEPNSE 109

                          90
                  ....*....|..
gi 1622831293 358 VVTMARMLQDVF 369
Cdd:cd05529   110 IAKKAKRLSDWL 121
Bromo_brd1_like cd05512
Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein ...
 52-109 2.20e-11

Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99944  Cd Length: 98  Bit Score: 61.26  E-value: 2.20e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622831293  52 FQRPVDAVKLklPDYYTIIKNPMDLNTIKKRLENKYYVKASECIEDFNTMFSNCYLYN 109
Cdd:cd05512    22 FSEPVDLSEV--PDYLDHIKQPMDFSTMRKKLESQRYRTLEDFEADFNLIINNCLAYN 77
Bromo_brd1_like cd05512
Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein ...
 295-355 7.16e-11

Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99944  Cd Length: 98  Bit Score: 59.72  E-value: 7.16e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622831293 295 FYNPVDVNALglHNYYDIVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPD 355
Cdd:cd05512    22 FSEPVDLSEV--PDYLDHIKQPMDFSTMRKKLESQRYRTLEDFEADFNLIINNCLAYNAKD 80
Bromo_polybromo_I cd05524
Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which ...
 309-376 1.99e-10

Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99954 [Multi-domain]  Cd Length: 113  Bit Score: 58.88  E-value: 1.99e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622831293 309 YYDIVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPDHEVVTMARMLQDVFETHFSKI 376
Cdd:cd05524    41 YYEVVSNPIDLLKIQQKLKTEEYDDVDDLTADFELLINNAKAYYKPDSPEHKDACKLWELFLSARNEV 108
BRD4_CDT pfam17105
C-terminal domain of bromodomain protein 4; BRD4_CDT is the short highly conserved C-terminal ...
 905-947 2.58e-10

C-terminal domain of bromodomain protein 4; BRD4_CDT is the short highly conserved C-terminal domain of certain bromodomain proteins, notably Brd4. The Brd4 CTD interacts with the cyclin T1 and Cdk9 subunits of positive transcription elongation factor b (pTEFb) complex. Brd4 displaces negative regulators, the HEXIM1 and 7SKsnRNA complex, from pTEFb, thereby transforming it into an active form that can phosphorylate RNA pol II.


Pssm-ID: 465349  Cd Length: 44  Bit Score: 56.25  E-value: 2.58e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1622831293 905 WLLKDRNLAREKEQERRRREAMAGTIDMTLQSDIMTMFENNFD 947
Cdd:pfam17105   2 SLDKERELARKREQERRRREAMAGTIDMNLQSDIMASFEENLD 44
Bromo_polybromo_II cd05517
Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which ...
 60-129 2.66e-10

Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99948  Cd Length: 103  Bit Score: 58.22  E-value: 2.66e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293  60 KLKLPDYYTIIKNPMDLNTIKKRLENKYYVKASECIEDFNTMFSNCYLYNKPGDDIVLMAQALEKLFMQK 129
Cdd:cd05517    33 KVLYPDYYAVIKEPIDLKTIAQRIQSGYYKSIEDMEKDLDLMVKNAKTFNEPGSQVYKDANAIKKIFTAK 102
Bromo_brd7_like cd05513
Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown ...
 273-355 3.48e-10

Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene involved in nasopharyngeal carcinoma. The protein interacts with acetylated histone H3 via its bromodomain. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99945  Cd Length: 98  Bit Score: 57.81  E-value: 3.48e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293 273 LRHCSEILKEMLAKK--HFSYAWPfynpvdVNALGLHNYYDIVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYK 350
Cdd:cd05513     2 LQKALEQLIRQLQRKdpHGFFAFP------VTDFIAPGYSSIIKHPMDFSTMKEKIKNNDYQSIEEFKDDFKLMCENAMK 75


                  ....*
gi 1622831293 351 YNPPD 355
Cdd:cd05513    76 YNKPD 80
Bromo_AAA cd05528
Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long ...
 31-133 6.49e-10

Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this alignment is an uncharacterized protein predicted from analysis of cDNA clones from human fetal liver


Pssm-ID: 99957  Cd Length: 112  Bit Score: 57.37  E-value: 6.49e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293  31 QLQYLQKVVLKDLWKHSFSWPFQRPVDAVKLklPDYYTIIKNPMDLNTIKKRLENKYYVKASECIEDFNTMFSNCYLYNk 110
Cdd:cd05528     3 ELRLFLRDVLKRLASDKRFNAFTKPVDEEEV--PDYYEIIKQPMDLQTILQKLDTHQYLTAKDFLKDIDLIVTNALEYN- 79

                          90       100
                  ....*....|....*....|....*...
gi 1622831293 111 PGDD-----IVLMAQALEKLFMQKLSQM 133
Cdd:cd05528    80 PDRDpadklIRSRACELRDEVHAMIEAE 107
Bromo_Rsc1_2_I cd05521
Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are ...
 60-124 7.70e-10

Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two bromodomains. The RSC complex has also been linked to homologous recombination and nonhomologous end-joining repair of DNA double strand breaks. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99952  Cd Length: 106  Bit Score: 56.95  E-value: 7.70e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622831293  60 KLKLPDYYTIIKNPMDLNTIKKRLenKYYVKASECIEDFNTMFSNCYLYNKPGDDIVLMAQALEK 124
Cdd:cd05521    34 RKDYPDYYKIIKNPLSLNTVKKRL--PHYTNAQEFVNDLAQIPWNARLYNTKGSVIYKYALILEK 96
Bromo_polybromo_III cd05520
Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which ...
 309-368 1.15e-09

Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99951  Cd Length: 103  Bit Score: 56.58  E-value: 1.15e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293 309 YYDIVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPDHEVVTMARMLQDV 368
Cdd:cd05520    39 YYQEIKNPISLQQIRTKLKNGEYETLEELEADLNLMFENAKRYNVPNSRIYKDAEKLQKL 98
Bromo_WDR9_II cd05496
Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 37-133 1.41e-09

Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99928  Cd Length: 119  Bit Score: 56.70  E-value: 1.41e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293  37 KVVLKDLWKHSFSWPFQRPVDavKLKLPDYYTIIKNPMDLNTIKKRLENKYYVKASECIEDFNTMFSNCYLYN-KPGDDI 115
Cdd:cd05496    11 KELVNLMWDCEDSEPFRQPVD--LLKYPDYRDIIDTPMDLGTVKETLFGGNYDDPMEFAKDVRLIFSNSKSYTpNKRSRI 88

                          90
                  ....*....|....*...
gi 1622831293 116 VLMAQALEKLFMQKLSQM 133
Cdd:cd05496    89 YSMTLRLSALFEEHIKKI 106
Bromo_polybromo_III cd05520
Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which ...
 48-130 2.38e-09

Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99951  Cd Length: 103  Bit Score: 55.42  E-value: 2.38e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293  48 FSWPFQR-PVdavKLKLPDYYTIIKNPMDLNTIKKRLENKYYVKASECIEDFNTMFSNCYLYNKPGDDIVLMAQALEKLF 126
Cdd:cd05520    23 LAEPFLKlPS---KRKYPDYYQEIKNPISLQQIRTKLKNGEYETLEELEADLNLMFENAKRYNVPNSRIYKDAEKLQKLM 99


                  ....
gi 1622831293 127 MQKL 130
Cdd:cd05520   100 QAKK 103
Bromo_brd7_like cd05513
Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown ...
 28-112 5.75e-09

Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene involved in nasopharyngeal carcinoma. The protein interacts with acetylated histone H3 via its bromodomain. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99945  Cd Length: 98  Bit Score: 54.34  E-value: 5.75e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293  28 LTNQLQYLQKvvlKDLwKHSFSWPFQrpvDAVKlklPDYYTIIKNPMDLNTIKKRLENKYYVKASECIEDFNTMFSNCYL 107
Cdd:cd05513     6 LEQLIRQLQR---KDP-HGFFAFPVT---DFIA---PGYSSIIKHPMDFSTMKEKIKNNDYQSIEEFKDDFKLMCENAMK 75


                  ....*
gi 1622831293 108 YNKPG 112
Cdd:cd05513    76 YNKPD 80
Bromo_Rsc1_2_II cd05522
Bromodomain, repeat II in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are ...
 308-366 2.61e-07

Bromodomain, repeat II in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two bromodomains. The RSC complex has also been linked to homologous recombination and nonhomologous end-joining repair of DNA double strand breaks. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99953 [Multi-domain]  Cd Length: 104  Bit Score: 49.55  E-value: 2.61e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622831293 308 NYYDIVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPDHEVVTMARMLQ 366
Cdd:cd05522    39 EYYQEISNPISLDDIKKKVKRRKYKSFDQFLNDLNLMFENAKLYNENDSQEYKDAVLLE 97
Bromodomain_1 cd05494
Bromodomain; uncharacterized subfamily. Bromodomains are found in many chromatin-associated ...
 276-342 2.94e-07

Bromodomain; uncharacterized subfamily. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99926 [Multi-domain]  Cd Length: 114  Bit Score: 49.75  E-value: 2.94e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293 276 CSEILKEMLAKKHFSYAWPFYNPVDVNALGLHNYYDIVKNPMDLGTI---KEKMDNQEYKDAYKFAADVR 342
Cdd:cd05494     5 LERVLRELKRHRRNEDAWPFLEPVNPPRRGAPDYRDVIKRPMSFGTKvnnIVETGARDLEDLQIVQEDPA 74
Bromo_SP100C_like cd05501
Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major ...
 65-126 3.28e-07

Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin level. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99933  Cd Length: 102  Bit Score: 49.35  E-value: 3.28e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622831293  65 DYYTIIKNPMDLNTIKKRLENKYYVKASECIEDFNTMFSNCYLYNKpGDDIVLMAQALEKLF 126
Cdd:cd05501    32 DYCQGIKEPMWLNKVKERLNERVYHTVEGFVRDMRLIFHNHKLFYK-DDDFGQVGITLEKKF 92
Bromo_ASH1 cd05525
Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the ...
 60-128 6.79e-07

Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the trithorax-group in Drosophila melanogaster, an epigenetic transcriptional regulator of HOX genes. Drosophila ASH1 has been shown to methylate specific lysines in histones H3 and H4. Mammalian ASH1 has been shown to methylate histone H3. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99955 [Multi-domain]  Cd Length: 106  Bit Score: 48.54  E-value: 6.79e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622831293  60 KLKLPDYYTIIKNPMDLNTIKKRLENKYYVKASECIEDFNTMFSNCYLYNKPGDDIVLMAQALEKLFMQ 128
Cdd:cd05525    35 KKKNPDYYERITDPVDLSTIEKQILTGYYKTPEAFDSDMLKVFRNAEKYYGRKSPIGRDVCRLRKAYYQ 103
Bromo_polybromo_IV cd05518
Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which ...
 308-368 1.53e-06

Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99949 [Multi-domain]  Cd Length: 103  Bit Score: 47.44  E-value: 1.53e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622831293 308 NYYDIVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPDHEVVTMARMLQDV 368
Cdd:cd05518    38 DYYKIILEPIDLKTIEHNIRNDKYATEEELMDDFKLMFRNARHYNEEGSQVYEDANILEKV 98
Bromodomain_1 cd05494
Bromodomain; uncharacterized subfamily. Bromodomains are found in many chromatin-associated ...
 32-84 2.01e-06

Bromodomain; uncharacterized subfamily. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99926 [Multi-domain]  Cd Length: 114  Bit Score: 47.44  E-value: 2.01e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1622831293  32 LQYLQKV--VLKDLWKHSFSWPFQRPVDAVKLKLPDYYTIIKNPMDLNTIKKRLE 84
Cdd:cd05494     2 YEALERVlrELKRHRRNEDAWPFLEPVNPPRRGAPDYRDVIKRPMSFGTKVNNIV 56
Bromo_SNF2L2 cd05516
Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI ...
 306-376 2.54e-06

Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone receptors to boost transcriptional activation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99947  Cd Length: 107  Bit Score: 47.04  E-value: 2.54e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622831293 306 LHNYYDIVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPDHEVVTMARMLQDVFETHFSKI 376
Cdd:cd05516    37 LPEYYELIRKPVDFKKIKERIRNHKYRSLEDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFKSARQKI 107
Bromo_SP100C_like cd05501
Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major ...
 309-376 3.05e-06

Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin level. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99933  Cd Length: 102  Bit Score: 46.65  E-value: 3.05e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622831293 309 YYDIVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPDhEVVTMARMLQDVFETHFSKI 376
Cdd:cd05501    33 YCQGIKEPMWLNKVKERLNERVYHTVEGFVRDMRLIFHNHKLFYKDD-DFGQVGITLEKKFEKNFKEV 99
Bromo_SNF2 cd05519
Bromodomain, SNF2-like subfamily, specific to fungi. SNF2 is a yeast protein involved in ...
 309-373 3.45e-06

Bromodomain, SNF2-like subfamily, specific to fungi. SNF2 is a yeast protein involved in transcriptional activation, it is the catalytic component of the SWI/SNF ATP-dependent chromatin remodeling complex. The protein is essential for the regulation of gene expression (both positive and negative) of a large number of genes. The SWI/SNF complex changes chromatin structure by altering DNA-histone contacts within the nucleosome, which results in a re-positioning of the nucleosome and facilitates or represses the binding of gene-specific transcription factors. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99950  Cd Length: 103  Bit Score: 46.56  E-value: 3.45e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622831293 309 YYDIVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPDHEVVTMARMLQDVFETHF 373
Cdd:cd05519    39 YYVIIKRPIALDQIKRRIEGRAYKSLEEFLEDFHLMFANARTYNQEGSIVYEDAVEMEKAFKKKY 103
Bromo_RACK7 cd05508
Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) ...
 29-130 1.58e-05

Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular proliferation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99940  Cd Length: 99  Bit Score: 44.68  E-value: 1.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293  29 TNQLQYLQKVVLKDLwKHSFSWPFQRPVDavKLKLPDYYTIIKNPMDLNTIKKRLENKYYVKASECIEDFNTMFSNCYLY 108
Cdd:cd05508     1 VDQLSKLLKFALERM-KQPGAEPFLKPVD--LEQFPDYAQYVFKPMDLSTLEKNVRKKAYGSTDAFLADAKWILHNAIIY 77

                          90       100
                  ....*....|....*....|..
gi 1622831293 109 NKPGDDIVLMAQALEKLFMQKL 130
Cdd:cd05508    78 NGGDHKLTQAAKAIVKICEQEM 99
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 46-131 2.40e-05

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 47.49  E-value: 2.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293  46 HSFSWPFQRPVDavKLKLPDYYTIIKNPMDLNTIKKRLENKYYVKASECIEDFNTMFSNCYLYNKPGDDIVLMAQALEKL 125
Cdd:COG5076   278 HVGAWPFLRPVS--DEEVPDYYKDIRDPMDLSTKELKLRNNYYRPEETFVRDAKLFFDNCVMYNGEVTDYYKNANVLEDF 355


                  ....*.
gi 1622831293 126 FMQKLS 131
Cdd:COG5076   356 VIKKTR 361
Bromo_polybromo_I cd05524
Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which ...
 64-137 4.16e-05

Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99954 [Multi-domain]  Cd Length: 113  Bit Score: 43.86  E-value: 4.16e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622831293  64 PDYYTIIKNPMDLNTIKKRLENKYYVKASECIEDFNTMFSNCYLYNKPGDDIVLMAQALEKLFMQKLSQMPQEE 137
Cdd:cd05524    39 PEYYEVVSNPIDLLKIQQKLKTEEYDDVDDLTADFELLINNAKAYYKPDSPEHKDACKLWELFLSARNEVLSGG 112
Bromo_RACK7 cd05508
Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) ...
 270-365 5.04e-05

Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular proliferation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99940  Cd Length: 99  Bit Score: 43.14  E-value: 5.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622831293 270 TEQLrhcSEILKEMLAKKHFSYAWPFYNPVDVNALglHNYYDIVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCY 349
Cdd:cd05508     1 VDQL---SKLLKFALERMKQPGAEPFLKPVDLEQF--PDYAQYVFKPMDLSTLEKNVRKKAYGSTDAFLADAKWILHNAI 75

                          90
                  ....*....|....*.
gi 1622831293 350 KYNPPDHEVVTMARML 365
Cdd:cd05508    76 IYNGGDHKLTQAAKAI 91
Bromo_Rsc1_2_I cd05521
Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are ...
 309-367 6.74e-05

Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two bromodomains. The RSC complex has also been linked to homologous recombination and nonhomologous end-joining repair of DNA double strand breaks. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99952  Cd Length: 106  Bit Score: 43.08  E-value: 6.74e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622831293 309 YYDIVKNPMDLGTIKEKMDNqeYKDAYKFAADVRLMFMNCYKYNPPDHEVVTMARMLQD 367
Cdd:cd05521    40 YYKIIKNPLSLNTVKKRLPH--YTNAQEFVNDLAQIPWNARLYNTKGSVIYKYALILEK 96
Bromo_polybromo_II cd05517
Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which ...
 309-369 2.86e-04

Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99948  Cd Length: 103  Bit Score: 40.89  E-value: 2.86e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622831293 309 YYDIVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPDHEVVTMARMLQDVF 369
Cdd:cd05517    39 YYAVIKEPIDLKTIAQRIQSGYYKSIEDMEKDLDLMVKNAKTFNEPGSQVYKDANAIKKIF 99
Bromo_ASH1 cd05525
Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the ...
 309-371 7.23e-04

Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the trithorax-group in Drosophila melanogaster, an epigenetic transcriptional regulator of HOX genes. Drosophila ASH1 has been shown to methylate specific lysines in histones H3 and H4. Mammalian ASH1 has been shown to methylate histone H3. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99955 [Multi-domain]  Cd Length: 106  Bit Score: 40.07  E-value: 7.23e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622831293 309 YYDIVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPDHEVVTMARMLQDVFET 371
Cdd:cd05525    41 YYERITDPVDLSTIEKQILTGYYKTPEAFDSDMLKVFRNAEKYYGRKSPIGRDVCRLRKAYYQ 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH