NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|966957029|ref|XP_015000144|]
View 

zinc finger protein 596 isoform X3 [Macaca mulatta]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
286-427 6.08e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.78  E-value: 6.08e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966957029 286 KPHGCHLCGKAFTESSVLKRHER--IHTGE--KPYECHV--CGKAFTESSDLRRHERTHTGEKPYECHL--CGKAFNHSS 357
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPLL 367

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966957029 358 VLRRHERTH-----TGEKPYEC--NICGKAFNRSYNFRLHKRVHTGEKPYVC--LLCGKAFSKFFNLRQHERTHTKKVM 427
Cdd:COG5048  368 NNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAP 446
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
24-274 1.36e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.55  E-value: 1.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966957029  24 TSTISTMRSHTQEDPFLCNDLGEDvTEHTALTQNVITYMRKKHFVSKKFGKTFSDwvqhkEIHTRCKSDEGHLFDYAFIQ 103
Cdd:COG5048  198 SSSENSPLSSSYSIPSSSSDQNLE-NSSSSLPLTTNSQLSPKSLLSQSPSSLSSS-----DSSSSASESPRSSLPTASSQ 271

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966957029 104 NSALRPHNVTHTRVITL--ECHVCGKTFSKNSNLRRH--EMIHTGE--KPHGC--HLCGKAFTHCSDLRKHERTHTGEKP 175
Cdd:COG5048  272 SSSPNESDSSSEKGFSLpiKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966957029 176 YGCHL--CGKAFSKSSNLRRHEMIH-------TREKAQVCHLCGKAFTHCSDLRKHERTHLGDKPYGCH--LCGKAFSKC 244
Cdd:COG5048  352 AKEKLlnSSSKFSPLLNNEPPQSLQqykdlknDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRH 431

                        250       260       270
                 ....*....|....*....|....*....|..
gi 966957029 245 SYLRQHERTHNGEKPYECHLCGK--AFSHCSH 274
Cdd:COG5048  432 YNLIPHKKIHTNHAPLLCSILKSfrRDLDLSN 463
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
286-427 6.08e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.78  E-value: 6.08e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966957029 286 KPHGCHLCGKAFTESSVLKRHER--IHTGE--KPYECHV--CGKAFTESSDLRRHERTHTGEKPYECHL--CGKAFNHSS 357
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPLL 367

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966957029 358 VLRRHERTH-----TGEKPYEC--NICGKAFNRSYNFRLHKRVHTGEKPYVC--LLCGKAFSKFFNLRQHERTHTKKVM 427
Cdd:COG5048  368 NNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAP 446
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
24-274 1.36e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.55  E-value: 1.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966957029  24 TSTISTMRSHTQEDPFLCNDLGEDvTEHTALTQNVITYMRKKHFVSKKFGKTFSDwvqhkEIHTRCKSDEGHLFDYAFIQ 103
Cdd:COG5048  198 SSSENSPLSSSYSIPSSSSDQNLE-NSSSSLPLTTNSQLSPKSLLSQSPSSLSSS-----DSSSSASESPRSSLPTASSQ 271

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966957029 104 NSALRPHNVTHTRVITL--ECHVCGKTFSKNSNLRRH--EMIHTGE--KPHGC--HLCGKAFTHCSDLRKHERTHTGEKP 175
Cdd:COG5048  272 SSSPNESDSSSEKGFSLpiKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966957029 176 YGCHL--CGKAFSKSSNLRRHEMIH-------TREKAQVCHLCGKAFTHCSDLRKHERTHLGDKPYGCH--LCGKAFSKC 244
Cdd:COG5048  352 AKEKLlnSSSKFSPLLNNEPPQSLQqykdlknDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRH 431

                        250       260       270
                 ....*....|....*....|....*....|..
gi 966957029 245 SYLRQHERTHNGEKPYECHLCGK--AFSHCSH 274
Cdd:COG5048  432 YNLIPHKKIHTNHAPLLCSILKSfrRDLDLSN 463
zf-H2C2_2 pfam13465
Zinc-finger double domain;
330-355 4.11e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.11e-04
                          10        20
                  ....*....|....*....|....*.
gi 966957029  330 DLRRHERTHTGEKPYECHLCGKAFNH 355
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
246-271 3.64e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 3.64e-03
                          10        20
                  ....*....|....*....|....*.
gi 966957029  246 YLRQHERTHNGEKPYECHLCGKAFSH 271
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
286-427 6.08e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.78  E-value: 6.08e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966957029 286 KPHGCHLCGKAFTESSVLKRHER--IHTGE--KPYECHV--CGKAFTESSDLRRHERTHTGEKPYECHL--CGKAFNHSS 357
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPLL 367

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966957029 358 VLRRHERTH-----TGEKPYEC--NICGKAFNRSYNFRLHKRVHTGEKPYVC--LLCGKAFSKFFNLRQHERTHTKKVM 427
Cdd:COG5048  368 NNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAP 446
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
30-424 9.45e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.01  E-value: 9.45e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966957029  30 MRSHTQEDPFLCNDLGED---VTEHTALTQNVITYMRKKHFVSKKFGKTFSDWVQHKEIHTRCKSDE---GHLFDYAFIQ 103
Cdd:COG5048   53 IRSHTGEKPSQCSYSGCDksfSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSSSNSNDnnlLSSHSLPPSS 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966957029 104 NSALRPHNVTHTRVITLECHVCGKTF--SKNSNLRRHEMIHtgekphgcHLCGKAFTHCSDLRKHERTHTgekPYGCHLC 181
Cdd:COG5048  133 RDPQLPDLLSISNLRNNPLPGNNSSSvnTPQSNSLHPPLPA--------NSLSKDPSSNLSLLISSNVST---SIPSSSE 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966957029 182 GKAFSKSSNLRRHEMIHTREKAQVCHLCGKAFTHCSDLRKHERTHLGDKPYGCHLCGKAFSKCSYLRQHERTHN------ 255
Cdd:COG5048  202 NSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPnesdss 281

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966957029 256 ----GEKPYECHLCGKAFSHCSHLRQHERS--HNGE--KPHGC--HLCGKAFTESSVLKRHERIHTGEKPYECH--VCGK 323
Cdd:COG5048  282 sekgFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllNSSS 361

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966957029 324 AFTESSDLRRHERTH-----TGEKPYEC--HLCGKAFNHSSVLRRHERTHTGEKPYECN--ICGKAFNRSYNFRLHKRVH 394
Cdd:COG5048  362 KFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIH 441

                        410       420       430
                 ....*....|....*....|....*....|
gi 966957029 395 TGEKPYVCLLCgkafsKFFNLRQHERTHTK 424
Cdd:COG5048  442 TNHAPLLCSIL-----KSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
24-274 1.36e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.55  E-value: 1.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966957029  24 TSTISTMRSHTQEDPFLCNDLGEDvTEHTALTQNVITYMRKKHFVSKKFGKTFSDwvqhkEIHTRCKSDEGHLFDYAFIQ 103
Cdd:COG5048  198 SSSENSPLSSSYSIPSSSSDQNLE-NSSSSLPLTTNSQLSPKSLLSQSPSSLSSS-----DSSSSASESPRSSLPTASSQ 271

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966957029 104 NSALRPHNVTHTRVITL--ECHVCGKTFSKNSNLRRH--EMIHTGE--KPHGC--HLCGKAFTHCSDLRKHERTHTGEKP 175
Cdd:COG5048  272 SSSPNESDSSSEKGFSLpiKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966957029 176 YGCHL--CGKAFSKSSNLRRHEMIH-------TREKAQVCHLCGKAFTHCSDLRKHERTHLGDKPYGCH--LCGKAFSKC 244
Cdd:COG5048  352 AKEKLlnSSSKFSPLLNNEPPQSLQqykdlknDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRH 431

                        250       260       270
                 ....*....|....*....|....*....|..
gi 966957029 245 SYLRQHERTHNGEKPYECHLCGK--AFSHCSH 274
Cdd:COG5048  432 YNLIPHKKIHTNHAPLLCSILKSfrRDLDLSN 463
zf-H2C2_2 pfam13465
Zinc-finger double domain;
330-355 4.11e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.11e-04
                          10        20
                  ....*....|....*....|....*.
gi 966957029  330 DLRRHERTHTGEKPYECHLCGKAFNH 355
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 256-339 5.30e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 5.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966957029 256 GEKPYECHL--CGKAFshcshlrqheRSHNGEKPHGCH-LCGKAFTESSVLKRHERIHTGEKPYECHVCGKAFTESSDLR 332
Cdd:COG5189  346 DGKPYKCPVegCNKKY----------KNQNGLKYHMLHgHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                 ....*..
gi 966957029 333 RHeRTHT 339
Cdd:COG5189  416 YH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
359-383 5.91e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 5.91e-04
                          10        20
                  ....*....|....*....|....*
gi 966957029  359 LRRHERTHTGEKPYECNICGKAFNR 383
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
146-425 7.03e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 7.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966957029 146 KPHGCHLCGKAFTHCSDLRKHERTHTGEKPYGCHL--CGKAFSKSSNLRRHEMIHTREKAQVC-HLCGKAFTHCSDLRKH 222
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966957029 223 ERTHLGDKPYGCHLCGKAF-----------SKCSYLRQHERTHNGEK-----------PYECHLCGKAFSHCSHLRQHER 280
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPssrdpqlpdllSISNLRNNPLPGNNSSSvntpqsnslhpPLPANSLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966957029 281 SHNGEKPHGCHLCGKAFTESSVLKRHERIHTGEKPYECHVCGKAFTESSDLRRH------ERTHTGEKPYECHLCGKAFN 354
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPsslsssDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966957029 355 HSSVLRRHERTHTG-EKPYECNICGKAFNRSYNFRLHKR--VHTGE--KPYVC--LLCGKAFSKFFNLRQHERTHTKK 425
Cdd:COG5048  272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSI 349
zf-H2C2_2 pfam13465
Zinc-finger double domain;
303-326 7.71e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 7.71e-04
                          10        20
                  ....*....|....*....|....
gi 966957029  303 LKRHERIHTGEKPYECHVCGKAFT 326
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 172-254 8.06e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 8.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966957029 172 GEKPYGCHL--CGKAFSKSSNLRRHeMIHTRekaqvchlCGKAFTHCSDLRKHERTHLGDKPYGCHLCGKAFSKCSYLRQ 249
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYH-MLHGH--------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*
gi 966957029 250 HeRTH 254
Cdd:COG5189  417 H-RKH 420
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 268-367 9.78e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 9.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966957029 268 AFSHCSHLRQHERSHN----GEKPHGCHL--CGKAFTESSVLKRHERihtgekpyECHvCGKAFTESSDLRRHERTHTGE 341
Cdd:COG5189  326 KLAHGGERNIDTPSRMlkvkDGKPYKCPVegCNKKYKNQNGLKYHML--------HGH-QNQKLHENPSPEKMNIFSAKD 396

                         90       100
                 ....*....|....*....|....*.
gi 966957029 342 KPYECHLCGKAFNHSSVLRRHeRTHT 367
Cdd:COG5189  397 KPYRCEVCDKRYKNLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
246-271 3.64e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 3.64e-03
                          10        20
                  ....*....|....*....|....*.
gi 966957029  246 YLRQHERTHNGEKPYECHLCGKAFSH 271
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH