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Conserved domains on  [gi|966957027|ref|XP_015000143|]
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zinc finger protein 596 isoform X2 [Macaca mulatta]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
289-430 5.22e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.17  E-value: 5.22e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966957027 289 KPHGCHLCGKAFTESSVLKRHER--IHTGE--KPYECHV--CGKAFTESSDLRRHERTHTGEKPYECHL--CGKAFNHSS 360
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPLL 367

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966957027 361 VLRRHERTH-----TGEKPYEC--NICGKAFNRSYNFRLHKRVHTGEKPYVC--LLCGKAFSKFFNLRQHERTHTKKVM 430
Cdd:COG5048  368 NNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAP 446
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
27-277 1.16e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.93  E-value: 1.16e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966957027  27 TSTISTMRSHTQEDPFLCNDLGEDvTEHTALTQNVITYMRKKHFVSKKFGKTFSDwvqhkEIHTRCKSDEGHLFDYAFIQ 106
Cdd:COG5048  198 SSSENSPLSSSYSIPSSSSDQNLE-NSSSSLPLTTNSQLSPKSLLSQSPSSLSSS-----DSSSSASESPRSSLPTASSQ 271

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966957027 107 NSALRPHNVTHTRVITL--ECHVCGKTFSKNSNLRRH--EMIHTGE--KPHGC--HLCGKAFTHCSDLRKHERTHTGEKP 178
Cdd:COG5048  272 SSSPNESDSSSEKGFSLpiKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966957027 179 YGCHL--CGKAFSKSSNLRRHEMIH-------TREKAQVCHLCGKAFTHCSDLRKHERTHLGDKPYGCH--LCGKAFSKC 247
Cdd:COG5048  352 AKEKLlnSSSKFSPLLNNEPPQSLQqykdlknDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRH 431

                        250       260       270
                 ....*....|....*....|....*....|..
gi 966957027 248 SYLRQHERTHNGEKPYECHLCGK--AFSHCSH 277
Cdd:COG5048  432 YNLIPHKKIHTNHAPLLCSILKSfrRDLDLSN 463
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
289-430 5.22e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.17  E-value: 5.22e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966957027 289 KPHGCHLCGKAFTESSVLKRHER--IHTGE--KPYECHV--CGKAFTESSDLRRHERTHTGEKPYECHL--CGKAFNHSS 360
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPLL 367

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966957027 361 VLRRHERTH-----TGEKPYEC--NICGKAFNRSYNFRLHKRVHTGEKPYVC--LLCGKAFSKFFNLRQHERTHTKKVM 430
Cdd:COG5048  368 NNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAP 446
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
27-277 1.16e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.93  E-value: 1.16e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966957027  27 TSTISTMRSHTQEDPFLCNDLGEDvTEHTALTQNVITYMRKKHFVSKKFGKTFSDwvqhkEIHTRCKSDEGHLFDYAFIQ 106
Cdd:COG5048  198 SSSENSPLSSSYSIPSSSSDQNLE-NSSSSLPLTTNSQLSPKSLLSQSPSSLSSS-----DSSSSASESPRSSLPTASSQ 271

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966957027 107 NSALRPHNVTHTRVITL--ECHVCGKTFSKNSNLRRH--EMIHTGE--KPHGC--HLCGKAFTHCSDLRKHERTHTGEKP 178
Cdd:COG5048  272 SSSPNESDSSSEKGFSLpiKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966957027 179 YGCHL--CGKAFSKSSNLRRHEMIH-------TREKAQVCHLCGKAFTHCSDLRKHERTHLGDKPYGCH--LCGKAFSKC 247
Cdd:COG5048  352 AKEKLlnSSSKFSPLLNNEPPQSLQqykdlknDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRH 431

                        250       260       270
                 ....*....|....*....|....*....|..
gi 966957027 248 SYLRQHERTHNGEKPYECHLCGK--AFSHCSH 277
Cdd:COG5048  432 YNLIPHKKIHTNHAPLLCSILKSfrRDLDLSN 463
zf-H2C2_2 pfam13465
Zinc-finger double domain;
333-358 3.72e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.72e-04
                          10        20
                  ....*....|....*....|....*.
gi 966957027  333 DLRRHERTHTGEKPYECHLCGKAFNH 358
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
249-274 3.35e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.35e-03
                          10        20
                  ....*....|....*....|....*.
gi 966957027  249 YLRQHERTHNGEKPYECHLCGKAFSH 274
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
289-430 5.22e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.17  E-value: 5.22e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966957027 289 KPHGCHLCGKAFTESSVLKRHER--IHTGE--KPYECHV--CGKAFTESSDLRRHERTHTGEKPYECHL--CGKAFNHSS 360
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPLL 367

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966957027 361 VLRRHERTH-----TGEKPYEC--NICGKAFNRSYNFRLHKRVHTGEKPYVC--LLCGKAFSKFFNLRQHERTHTKKVM 430
Cdd:COG5048  368 NNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAP 446
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
33-427 7.49e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.40  E-value: 7.49e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966957027  33 MRSHTQEDPFLCNDLGED---VTEHTALTQNVITYMRKKHFVSKKFGKTFSDWVQHKEIHTRCKSDE---GHLFDYAFIQ 106
Cdd:COG5048   53 IRSHTGEKPSQCSYSGCDksfSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSSSNSNDnnlLSSHSLPPSS 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966957027 107 NSALRPHNVTHTRVITLECHVCGKTF--SKNSNLRRHEMIHtgekphgcHLCGKAFTHCSDLRKHERTHTgekPYGCHLC 184
Cdd:COG5048  133 RDPQLPDLLSISNLRNNPLPGNNSSSvnTPQSNSLHPPLPA--------NSLSKDPSSNLSLLISSNVST---SIPSSSE 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966957027 185 GKAFSKSSNLRRHEMIHTREKAQVCHLCGKAFTHCSDLRKHERTHLGDKPYGCHLCGKAFSKCSYLRQHERTHN------ 258
Cdd:COG5048  202 NSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPnesdss 281

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966957027 259 ----GEKPYECHLCGKAFSHCSHLRQHERS--HNGE--KPHGC--HLCGKAFTESSVLKRHERIHTGEKPYECH--VCGK 326
Cdd:COG5048  282 sekgFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllNSSS 361

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966957027 327 AFTESSDLRRHERTH-----TGEKPYEC--HLCGKAFNHSSVLRRHERTHTGEKPYECN--ICGKAFNRSYNFRLHKRVH 397
Cdd:COG5048  362 KFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIH 441

                        410       420       430
                 ....*....|....*....|....*....|
gi 966957027 398 TGEKPYVCLLCgkafsKFFNLRQHERTHTK 427
Cdd:COG5048  442 TNHAPLLCSIL-----KSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
27-277 1.16e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.93  E-value: 1.16e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966957027  27 TSTISTMRSHTQEDPFLCNDLGEDvTEHTALTQNVITYMRKKHFVSKKFGKTFSDwvqhkEIHTRCKSDEGHLFDYAFIQ 106
Cdd:COG5048  198 SSSENSPLSSSYSIPSSSSDQNLE-NSSSSLPLTTNSQLSPKSLLSQSPSSLSSS-----DSSSSASESPRSSLPTASSQ 271

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966957027 107 NSALRPHNVTHTRVITL--ECHVCGKTFSKNSNLRRH--EMIHTGE--KPHGC--HLCGKAFTHCSDLRKHERTHTGEKP 178
Cdd:COG5048  272 SSSPNESDSSSEKGFSLpiKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966957027 179 YGCHL--CGKAFSKSSNLRRHEMIH-------TREKAQVCHLCGKAFTHCSDLRKHERTHLGDKPYGCH--LCGKAFSKC 247
Cdd:COG5048  352 AKEKLlnSSSKFSPLLNNEPPQSLQqykdlknDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRH 431

                        250       260       270
                 ....*....|....*....|....*....|..
gi 966957027 248 SYLRQHERTHNGEKPYECHLCGK--AFSHCSH 277
Cdd:COG5048  432 YNLIPHKKIHTNHAPLLCSILKSfrRDLDLSN 463
zf-H2C2_2 pfam13465
Zinc-finger double domain;
333-358 3.72e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.72e-04
                          10        20
                  ....*....|....*....|....*.
gi 966957027  333 DLRRHERTHTGEKPYECHLCGKAFNH 358
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 259-342 4.57e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 4.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966957027 259 GEKPYECHL--CGKAFshcshlrqheRSHNGEKPHGCH-LCGKAFTESSVLKRHERIHTGEKPYECHVCGKAFTESSDLR 335
Cdd:COG5189  346 DGKPYKCPVegCNKKY----------KNQNGLKYHMLHgHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                 ....*..
gi 966957027 336 RHeRTHT 342
Cdd:COG5189  416 YH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
362-386 5.34e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 5.34e-04
                          10        20
                  ....*....|....*....|....*
gi 966957027  362 LRRHERTHTGEKPYECNICGKAFNR 386
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
149-428 6.07e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 6.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966957027 149 KPHGCHLCGKAFTHCSDLRKHERTHTGEKPYGCHL--CGKAFSKSSNLRRHEMIHTREKAQVC-HLCGKAFTHCSDLRKH 225
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966957027 226 ERTHLGDKPYGCHLCGKAF-----------SKCSYLRQHERTHNGEK-----------PYECHLCGKAFSHCSHLRQHER 283
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPssrdpqlpdllSISNLRNNPLPGNNSSSvntpqsnslhpPLPANSLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966957027 284 SHNGEKPHGCHLCGKAFTESSVLKRHERIHTGEKPYECHVCGKAFTESSDLRRH------ERTHTGEKPYECHLCGKAFN 357
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPsslsssDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966957027 358 HSSVLRRHERTHTG-EKPYECNICGKAFNRSYNFRLHKR--VHTGE--KPYVC--LLCGKAFSKFFNLRQHERTHTKK 428
Cdd:COG5048  272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSI 349
zf-H2C2_2 pfam13465
Zinc-finger double domain;
306-329 6.90e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 6.90e-04
                          10        20
                  ....*....|....*....|....
gi 966957027  306 LKRHERIHTGEKPYECHVCGKAFT 329
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 175-257 7.15e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 7.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966957027 175 GEKPYGCHL--CGKAFSKSSNLRRHeMIHTRekaqvchlCGKAFTHCSDLRKHERTHLGDKPYGCHLCGKAFSKCSYLRQ 252
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYH-MLHGH--------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*
gi 966957027 253 HeRTH 257
Cdd:COG5189  417 H-RKH 420
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 271-370 8.44e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 8.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966957027 271 AFSHCSHLRQHERSHN----GEKPHGCHL--CGKAFTESSVLKRHERihtgekpyECHvCGKAFTESSDLRRHERTHTGE 344
Cdd:COG5189  326 KLAHGGERNIDTPSRMlkvkDGKPYKCPVegCNKKYKNQNGLKYHML--------HGH-QNQKLHENPSPEKMNIFSAKD 396

                         90       100
                 ....*....|....*....|....*.
gi 966957027 345 KPYECHLCGKAFNHSSVLRRHeRTHT 370
Cdd:COG5189  397 KPYRCEVCDKRYKNLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
249-274 3.35e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.35e-03
                          10        20
                  ....*....|....*....|....*.
gi 966957027  249 YLRQHERTHNGEKPYECHLCGKAFSH 274
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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