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Conserved domains on  [gi|966956578|ref|XP_014999947|]
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autophagy-related protein 2 homolog B isoform X3 [Macaca mulatta]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Chorein_N pfam12624
N-terminal region of Chorein or VPS13; Although mutations in the full-length vacuolar protein ...
 11-113 6.97e-16

N-terminal region of Chorein or VPS13; Although mutations in the full-length vacuolar protein sorting 13A (VPS13A) protein in vertebrates lead to the disease of chorea-acanthocytosis, the exact function of any of the regions within the protein is not yet known. This region is the proposed leucine zipper at the N-terminus. The full-length protein is a transmembrane protein with a presumed role in vesicle-mediated sorting and intracellular protein transport.


:

Pssm-ID: 463646  Cd Length: 116  Bit Score: 75.68  E-value: 6.97e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966956578    11 KRACRYLLQRYLGHFLqEKLSLEQLSLDLYQGTGSLAQVPLDKwclnEILESADAPLEVTEGFIQSISLSVPWGSLLQDN 90
Cdd:pfam12624    2 ESLVASLLNRYLGEYV-ENLDPDQLKVGLWSGDVVLENLKLKK----EALDKLDLPIEVKSGHIGKLTLKIPWTNLKSEP 76

                           90       100
                   ....*....|....*....|...
gi 966956578    91 CALEVRGLEMVFRPRPRPATGSE 113
Cdd:pfam12624   77 VVIEIEDVYLLAVPKDESEEYDE 99
MRS6 super family cl34879
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
17-234 2.94e-08

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5043:

Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 59.51  E-value: 2.94e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966956578   17 LLQRYLGHFLqEKLSLEQLSLDLYQGTGSLAQVPLDKwclnEILESADAPLEVTEGFIQSISLSVPWGSLLQDNCALEVR 96
Cdd:COG5043     9 LLNRLLGSYV-ENFDTKQLNVGVWGGDVSLHNLRIKP----SALDKLGLPIEVTSGLIGTLTLEIPWSSLKNKPVEIYIE 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966956578   97 GLEMVFRPRPRPATGSEPMYWSSFMTSSMQLAK-ECLSQklTDEQGEGSQPFEGLEKFAETIET-VLRRVKVTFIDTVLR 174
Cdd:COG5043    84 DIYLLISPQAKNSLTREELPQSQQALKQRQLDSwEILRE--TLEESSSSPNISRKQSFIESLITkLIDNIQIYIEDIHLR 161

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966956578  175 IEHVPENSKTG------TALEIRIERtvyCDETADESSginVHQPTAFAHKLLQLSGVSLFWDEFS 234
Cdd:COG5043   162 FEDNLSADLEGpysfglTLYSLRATS---TDASWTEYF---VSTDSSCIHKLITLDYFSIYWCEIS 221
ATG_C super family cl07826
Autophagy-related protein C terminal domain; ATG2 (also known as Apg2) is a peripheral ...
 1980-2004 6.28e-03

Autophagy-related protein C terminal domain; ATG2 (also known as Apg2) is a peripheral membrane protein. It functions in both cytoplasm-to-vacuole targeting and in autophagy.


The actual alignment was detected with superfamily member pfam09333:

Pssm-ID: 462761 [Multi-domain]  Cd Length: 96  Bit Score: 37.87  E-value: 6.28e-03
                           10        20
                   ....*....|....*....|....*
gi 966956578  1980 HRLAHQPVDLREGVAKAYSVVKEDF 2004
Cdd:pfam09333    2 SLYANQPEDVREGLQQAYSSLERGL 26
 
Name Accession Description Interval E-value
Chorein_N pfam12624
N-terminal region of Chorein or VPS13; Although mutations in the full-length vacuolar protein ...
 11-113 6.97e-16

N-terminal region of Chorein or VPS13; Although mutations in the full-length vacuolar protein sorting 13A (VPS13A) protein in vertebrates lead to the disease of chorea-acanthocytosis, the exact function of any of the regions within the protein is not yet known. This region is the proposed leucine zipper at the N-terminus. The full-length protein is a transmembrane protein with a presumed role in vesicle-mediated sorting and intracellular protein transport.


Pssm-ID: 463646  Cd Length: 116  Bit Score: 75.68  E-value: 6.97e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966956578    11 KRACRYLLQRYLGHFLqEKLSLEQLSLDLYQGTGSLAQVPLDKwclnEILESADAPLEVTEGFIQSISLSVPWGSLLQDN 90
Cdd:pfam12624    2 ESLVASLLNRYLGEYV-ENLDPDQLKVGLWSGDVVLENLKLKK----EALDKLDLPIEVKSGHIGKLTLKIPWTNLKSEP 76

                           90       100
                   ....*....|....*....|...
gi 966956578    91 CALEVRGLEMVFRPRPRPATGSE 113
Cdd:pfam12624   77 VVIEIEDVYLLAVPKDESEEYDE 99
MRS6 COG5043
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
17-234 2.94e-08

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 59.51  E-value: 2.94e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966956578   17 LLQRYLGHFLqEKLSLEQLSLDLYQGTGSLAQVPLDKwclnEILESADAPLEVTEGFIQSISLSVPWGSLLQDNCALEVR 96
Cdd:COG5043     9 LLNRLLGSYV-ENFDTKQLNVGVWGGDVSLHNLRIKP----SALDKLGLPIEVTSGLIGTLTLEIPWSSLKNKPVEIYIE 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966956578   97 GLEMVFRPRPRPATGSEPMYWSSFMTSSMQLAK-ECLSQklTDEQGEGSQPFEGLEKFAETIET-VLRRVKVTFIDTVLR 174
Cdd:COG5043    84 DIYLLISPQAKNSLTREELPQSQQALKQRQLDSwEILRE--TLEESSSSPNISRKQSFIESLITkLIDNIQIYIEDIHLR 161

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966956578  175 IEHVPENSKTG------TALEIRIERtvyCDETADESSginVHQPTAFAHKLLQLSGVSLFWDEFS 234
Cdd:COG5043   162 FEDNLSADLEGpysfglTLYSLRATS---TDASWTEYF---VSTDSSCIHKLITLDYFSIYWCEIS 221
ATG_C pfam09333
Autophagy-related protein C terminal domain; ATG2 (also known as Apg2) is a peripheral ...
 1980-2004 6.28e-03

Autophagy-related protein C terminal domain; ATG2 (also known as Apg2) is a peripheral membrane protein. It functions in both cytoplasm-to-vacuole targeting and in autophagy.


Pssm-ID: 462761 [Multi-domain]  Cd Length: 96  Bit Score: 37.87  E-value: 6.28e-03
                           10        20
                   ....*....|....*....|....*
gi 966956578  1980 HRLAHQPVDLREGVAKAYSVVKEDF 2004
Cdd:pfam09333    2 SLYANQPEDVREGLQQAYSSLERGL 26
 
Name Accession Description Interval E-value
Chorein_N pfam12624
N-terminal region of Chorein or VPS13; Although mutations in the full-length vacuolar protein ...
 11-113 6.97e-16

N-terminal region of Chorein or VPS13; Although mutations in the full-length vacuolar protein sorting 13A (VPS13A) protein in vertebrates lead to the disease of chorea-acanthocytosis, the exact function of any of the regions within the protein is not yet known. This region is the proposed leucine zipper at the N-terminus. The full-length protein is a transmembrane protein with a presumed role in vesicle-mediated sorting and intracellular protein transport.


Pssm-ID: 463646  Cd Length: 116  Bit Score: 75.68  E-value: 6.97e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966956578    11 KRACRYLLQRYLGHFLqEKLSLEQLSLDLYQGTGSLAQVPLDKwclnEILESADAPLEVTEGFIQSISLSVPWGSLLQDN 90
Cdd:pfam12624    2 ESLVASLLNRYLGEYV-ENLDPDQLKVGLWSGDVVLENLKLKK----EALDKLDLPIEVKSGHIGKLTLKIPWTNLKSEP 76

                           90       100
                   ....*....|....*....|...
gi 966956578    91 CALEVRGLEMVFRPRPRPATGSE 113
Cdd:pfam12624   77 VVIEIEDVYLLAVPKDESEEYDE 99
MRS6 COG5043
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
17-234 2.94e-08

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 59.51  E-value: 2.94e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966956578   17 LLQRYLGHFLqEKLSLEQLSLDLYQGTGSLAQVPLDKwclnEILESADAPLEVTEGFIQSISLSVPWGSLLQDNCALEVR 96
Cdd:COG5043     9 LLNRLLGSYV-ENFDTKQLNVGVWGGDVSLHNLRIKP----SALDKLGLPIEVTSGLIGTLTLEIPWSSLKNKPVEIYIE 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966956578   97 GLEMVFRPRPRPATGSEPMYWSSFMTSSMQLAK-ECLSQklTDEQGEGSQPFEGLEKFAETIET-VLRRVKVTFIDTVLR 174
Cdd:COG5043    84 DIYLLISPQAKNSLTREELPQSQQALKQRQLDSwEILRE--TLEESSSSPNISRKQSFIESLITkLIDNIQIYIEDIHLR 161

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966956578  175 IEHVPENSKTG------TALEIRIERtvyCDETADESSginVHQPTAFAHKLLQLSGVSLFWDEFS 234
Cdd:COG5043   162 FEDNLSADLEGpysfglTLYSLRATS---TDASWTEYF---VSTDSSCIHKLITLDYFSIYWCEIS 221
ATG_C pfam09333
Autophagy-related protein C terminal domain; ATG2 (also known as Apg2) is a peripheral ...
 1980-2004 6.28e-03

Autophagy-related protein C terminal domain; ATG2 (also known as Apg2) is a peripheral membrane protein. It functions in both cytoplasm-to-vacuole targeting and in autophagy.


Pssm-ID: 462761 [Multi-domain]  Cd Length: 96  Bit Score: 37.87  E-value: 6.28e-03
                           10        20
                   ....*....|....*....|....*
gi 966956578  1980 HRLAHQPVDLREGVAKAYSVVKEDF 2004
Cdd:pfam09333    2 SLYANQPEDVREGLQQAYSSLERGL 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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