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Conserved domains on  [gi|966954328|ref|XP_014998944|]
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leukotriene B4 receptor 1 [Macaca mulatta]

Protein Classification

G protein-coupled receptor family protein( domain architecture ID 705710)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tm_GPCRs super family cl28897
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
19-297 3.15e-120

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


The actual alignment was detected with superfamily member cd15121:

Pssm-ID: 475119 [Multi-domain]  Cd Length: 278  Bit Score: 347.96  E-value: 3.15e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  19 LLAIILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCG 98
Cdd:cd15121    1 QLGIAILSLAFILGFPGNLFVVWSVLCRMKKRSVTCILVLNLALADAAVLLTAPFFLHFLSGGGWEFGSVVCKLCHYVCG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  99 VSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALKTNMSLCYPKYPSKEHE 178
Cdd:cd15121   81 VSMYASIFLITLMSMDRCLAVAKPFLSQKMRTKRSVRALLLAIWIVAFLLSLPMPFYRTVLKKNINMKLCIPYHPSVGHE 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 179 AFHLIFEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILAFAAFWLPYHVVNLAEAARALAGQAsGSGL 258
Cdd:cd15121  161 AFQYLFETITGFLLPFTAIVTCYSTIGRRLRSARFRRKRRTNRLVVLIIATFALFWLPYHVVNLIQVAGALQNQA-GNAS 239
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 966954328 259 VGQRLKLARSVLIALAFLSSSVNPVLYACAGGGLLRSAG 297
Cdd:cd15121  240 VLKAAKLARPNVTALAFLSSSVNPVLYAFAGGSLIRSAG 278
 
Name Accession Description Interval E-value
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
19-297 3.15e-120

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 347.96  E-value: 3.15e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  19 LLAIILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCG 98
Cdd:cd15121    1 QLGIAILSLAFILGFPGNLFVVWSVLCRMKKRSVTCILVLNLALADAAVLLTAPFFLHFLSGGGWEFGSVVCKLCHYVCG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  99 VSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALKTNMSLCYPKYPSKEHE 178
Cdd:cd15121   81 VSMYASIFLITLMSMDRCLAVAKPFLSQKMRTKRSVRALLLAIWIVAFLLSLPMPFYRTVLKKNINMKLCIPYHPSVGHE 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 179 AFHLIFEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILAFAAFWLPYHVVNLAEAARALAGQAsGSGL 258
Cdd:cd15121  161 AFQYLFETITGFLLPFTAIVTCYSTIGRRLRSARFRRKRRTNRLVVLIIATFALFWLPYHVVNLIQVAGALQNQA-GNAS 239
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 966954328 259 VGQRLKLARSVLIALAFLSSSVNPVLYACAGGGLLRSAG 297
Cdd:cd15121  240 VLKAAKLARPNVTALAFLSSSVNPVLYAFAGGSLIRSAG 278
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
35-285 1.65e-34

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 127.03  E-value: 1.65e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328   35 GNSFVVWSILKRMKKRSVTALLVLNLALA-DLAVLLTAPFFL-HFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMS 112
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVAdLLFSLLTLPFWLvYYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  113 LDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALK-TNMSLCYPKYPSKEH-EAFHLIFEALTGF 190
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPeGNVTVCFIDFPEDLSkPVSYTLLISVLGF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  191 LLPFLAVVASYSDI--------GRRLQARRFRRSRRTGRLVVLIILAFAAFWLPYHVVNLaeaARALAGQASGSGLVgqr 262
Cdd:pfam00001 161 LLPLLVILVCYTLIirtlrksaSKQKSSERTQRRRKALKTLAVVVVVFILCWLPYHIVNL---LDSLALDCELSRLL--- 234
                         250       260
                  ....*....|....*....|...
gi 966954328  263 lKLARSVLIALAFLSSSVNPVLY 285
Cdd:pfam00001 235 -DKALSVTLWLAYVNSCLNPIIY 256
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
22-289 1.16e-17

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 82.52  E-value: 1.16e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  22 IILLSVALAVGLPGNsFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVSM 101
Cdd:PHA03087  44 IVVYSTIFFFGLVGN-IIVIYVLTKTKIKTPMDIYLLNLAVSDLLFVMTLPFQIYYYILFQWSFGEFACKIVSGLYYIGF 122
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 102 YASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVAlKTNMSLCYPKYPSKEH--EA 179
Cdd:PHA03087 123 YNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYTTKK-DHETLICCMFYNNKTMnwKL 201
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 180 FHLIFEALTGFLLPFLAVVASYSDI-GRRLQARRFRRSRRTGRLVVLIILAFAAFWLPYHVVNLAEAARALAGQASGSGL 258
Cdd:PHA03087 202 FINFEINIIGMLIPLTILLYCYSKIlITLKGINKSKKNKKAIKLVLIIVILFVIFWLPFNVSVFVYSLHILHFKSGCKAV 281
                        250       260       270
                 ....*....|....*....|....*....|.
gi 966954328 259 VGQRLKLARSVLIALafLSSSVNPVLYACAG 289
Cdd:PHA03087 282 KYIQYALHVTEIISL--SHCCINPLIYAFVS 310
 
Name Accession Description Interval E-value
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
19-297 3.15e-120

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 347.96  E-value: 3.15e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  19 LLAIILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCG 98
Cdd:cd15121    1 QLGIAILSLAFILGFPGNLFVVWSVLCRMKKRSVTCILVLNLALADAAVLLTAPFFLHFLSGGGWEFGSVVCKLCHYVCG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  99 VSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALKTNMSLCYPKYPSKEHE 178
Cdd:cd15121   81 VSMYASIFLITLMSMDRCLAVAKPFLSQKMRTKRSVRALLLAIWIVAFLLSLPMPFYRTVLKKNINMKLCIPYHPSVGHE 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 179 AFHLIFEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILAFAAFWLPYHVVNLAEAARALAGQAsGSGL 258
Cdd:cd15121  161 AFQYLFETITGFLLPFTAIVTCYSTIGRRLRSARFRRKRRTNRLVVLIIATFALFWLPYHVVNLIQVAGALQNQA-GNAS 239
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 966954328 259 VGQRLKLARSVLIALAFLSSSVNPVLYACAGGGLLRSAG 297
Cdd:cd15121  240 VLKAAKLARPNVTALAFLSSSVNPVLYAFAGGSLIRSAG 278
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
19-297 9.52e-105

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 308.64  E-value: 9.52e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  19 LLAIILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCG 98
Cdd:cd14975    1 VLGCTLLSLAFAIGLPGNSFVIWSILIKVKQRSVTMLLVLNLALADLAVLLTLPVWIYFLATGTWDFGLAACKGCVYVCA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  99 VSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVaLKTNMSLCYPKYPSKEHE 178
Cdd:cd14975   81 VSMYASVFLITLMSLERFLAVSRPFVSQGWRAKALAHKVLAIIWLLAVLLATPVIAFRHVE-ETVENGMCKYRHYSDGQL 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 179 AFHLIFEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILAFAAFWLPYHVVNLAEAARALAGQASGSGL 258
Cdd:cd14975  160 VFHLLLETVVGFAVPFTAVVLCYSCLLRRLRRRRFRRRRRTGRLIASVVVAFAACWLPYHVGNLLEVVSELIGGSKMAGT 239
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 966954328 259 VGQRLKLARSVLIALAFLSSSVNPVLYACAGGGLLRSAG 297
Cdd:cd14975  240 LGKVAEAGRPIAGALAFLSSSINPLLYAFAARGLFRSAG 278
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
22-297 7.80e-74

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 230.08  E-value: 7.80e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  22 IILLSVALAVGLPGNSFVVWSILKRMKKR--SVTALLVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGV 99
Cdd:cd15122    4 TIFLLLAALLGLPGNGFIIWSILWKMKARgrSVTCILILNLAVADGAVLLLTPFFITFLTRKTWPFGQAVCKAVYYLCCL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 100 SMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVA-LKTNMSLCYPKYPSKEHE 178
Cdd:cd15122   84 SMYASIFIIGLMSLDRCLAVTRPYLAQSLRKKALVRKILLAIWLLALLLALPAFVYRHVWKdEGMNDRICEPCHASRGHA 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 179 AFHLIFEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILAFAAFWLPYHVVNLAEAARALAGQASGSGL 258
Cdd:cd15122  164 IFHYTFETLVAFVLPFGVILFSYSVILVRLKGARFRRRARVEKLIAAIVVAFALLWVPYHVVNLLQVVANLAPGEVLEKL 243
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 966954328 259 vGQRLKLARSVLIALAFLSSSVNPVLYACAGGGLLRSAG 297
Cdd:cd15122  244 -GGAAKAARAGATALAFFSSSVNPLLYVFAAGDLIKTSG 281
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
19-289 7.09e-38

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 136.66  E-value: 7.09e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  19 LLAIILLSVALAVGLPGNSFVVWSILKRMKkRSVTALLVLNLALADLAVLLTAPFFLHFLAQGT-WSFGLAGCRLCHYVC 97
Cdd:cd14974    1 IVSLVLYALIFLLGLPGNGLVIWVAGFKMK-RTVNTVWFLNLALADFLFCLFLPFLIVYIAMGHhWPFGSVLCKLNSFVI 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  98 GVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALKTN------MSLCYPK 171
Cdd:cd14974   80 SLNMFASVFLLTAISLDRCLLVLHPVWAQNHRTVRLASVVCVGIWILALVLSVPYFVFRDTVTHHNGrscnltCVEDYDL 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 172 YPSKEHEAFHLIFeaLTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILAFAAFWLPYHVVNLAEAAralag 251
Cdd:cd14974  160 RRSRHKALTVIRF--LCGFLLPLLIIAICYSVIAVKLRRKRLAKSSKPLRVLLAVVVAFFLCWLPYHVFALLELV----- 232
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 966954328 252 QASGSGLVgqrLKLARSVLIALAFLSSSVNPVLYACAG 289
Cdd:cd14974  233 AAAGLPEV---VLLGLPLATGLAYFNSCLNPILYVFMG 267
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
22-286 2.85e-36

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 132.41  E-value: 2.85e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  22 IILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALA-DLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVS 100
Cdd:cd00637    2 AVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVAdLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSVS 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 101 MYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALkTNMSLCYPKYPSKEHEAF 180
Cdd:cd00637   82 LLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDY-GGYCCCCLCWPDLTLSKA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 181 HLIFEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGR---------------LVVLIILAFAAFWLPYHVVNLAEA 245
Cdd:cd00637  161 YTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIRSSSSNssrrrrrrrerkvtkTLLIVVVVFLLCWLPYFILLLLDV 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 966954328 246 AralagqasgSGLVGQRLKLARSVLIALAFLSSSVNPVLYA 286
Cdd:cd00637  241 F---------GPDPSPLPRILYFLALLLAYLNSAINPIIYA 272
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
23-286 8.69e-36

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 131.35  E-value: 8.69e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  23 ILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLA-QGTWSFGLAGCRLCHYVCGVSM 101
Cdd:cd14985    5 ALYIAIFLVGLLGNLFVVWVFLFPRGPKRVADIFIANLAAADLVFVLTLPLWATYTAnQYDWPFGAFLCKVSSYVISVNM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 102 YASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALK-TNMSLCYPKYPSkEHEAF 180
Cdd:cd14985   85 FASIFLLTCMSVDRYLAIVHPVASRRLRRRRQARVTCALIWVVACLLSLPTFLLRSLQAIEnLNKTACIMLYPH-EAWHF 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 181 HLIFEALT-GFLLPFLAVVASYSDIGRRLQARRFRRSRR------TGRLVVLIILAFAAFWLPYHVVNLAEAARALagQA 253
Cdd:cd14985  164 GLSLELNIlGFVLPLLIILTCYFHIARSLRKRYERTGKNgrkrrkSLKIIFALVVAFLVCWLPFHFFKFLDFLAQL--GA 241
                        250       260       270
                 ....*....|....*....|....*....|...
gi 966954328 254 SGSGLVGQRLKLARSVLIALAFLSSSVNPVLYA 286
Cdd:cd14985  242 IRPCFWELFLDLGLPIATCLAFTNSCLNPFIYV 274
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
20-295 6.12e-35

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 128.68  E-value: 6.12e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  20 LAIILLSVALAVGLPGNSFVVWSILKRMKkRSVTALLVLNLALADLAVLLTAPFFLHFLAQ-GTWSFGLAGCRLCHYVCG 98
Cdd:cd15114    2 VALVLYAVVFLVGVPGNALVAWVTGFEAK-RSVNAVWFLNLAVADLLCCLSLPILAVPIAQdGHWPFGAAACKLLPSLIL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  99 VSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALK-TNMSLCYPKYP-SKE 176
Cdd:cd15114   81 LNMYASVLLLTAISADRCLLVLRPVWCQNHRRARLAWIACGAAWLLALLLTVPSFIYRRIHQEHfPEKTVCVVDYGgSTG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 177 HEAFHLIFEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILAFAAFWLPYHVVNLAEAAralagqASGS 256
Cdd:cd15114  161 VEWAVAIIRFLLGFLGPLVVIASCHGVLLVRTWSRRRQKSRRTLKVVTAVVVGFFLCWTPYHVVGLIIAA------SAPN 234
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 966954328 257 GLVGQRLKLARSVLIALAFLSSSVNPVLYACAGGGLLRS 295
Cdd:cd15114  235 SRLLANALKADPLTVSLAYINSCLNPIIYVVAGRGFRKS 273
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
35-285 1.65e-34

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 127.03  E-value: 1.65e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328   35 GNSFVVWSILKRMKKRSVTALLVLNLALA-DLAVLLTAPFFL-HFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMS 112
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVAdLLFSLLTLPFWLvYYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  113 LDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALK-TNMSLCYPKYPSKEH-EAFHLIFEALTGF 190
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPeGNVTVCFIDFPEDLSkPVSYTLLISVLGF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  191 LLPFLAVVASYSDI--------GRRLQARRFRRSRRTGRLVVLIILAFAAFWLPYHVVNLaeaARALAGQASGSGLVgqr 262
Cdd:pfam00001 161 LLPLLVILVCYTLIirtlrksaSKQKSSERTQRRRKALKTLAVVVVVFILCWLPYHIVNL---LDSLALDCELSRLL--- 234
                         250       260
                  ....*....|....*....|...
gi 966954328  263 lKLARSVLIALAFLSSSVNPVLY 285
Cdd:pfam00001 235 -DKALSVTLWLAYVNSCLNPIIY 256
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
19-289 2.28e-33

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 124.50  E-value: 2.28e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  19 LLAIILLSVALAVGLPGNSFVVWSILKRMKkRSVTALLVLNLALADLAVLLTAPFFL-HFLAQGTWSFGLAGCRLCHYVC 97
Cdd:cd15115    1 ILSLVVLSLTFLLGVPGNGLVIWVAGLKMK-RTVNTIWFLNLAVADLLCCLSLPFSIaHLLLNGHWPYGRFLCKLLPSII 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  98 GVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVaLKTNMSLCYPKYPSKEH 177
Cdd:cd15115   80 VLNMFASVFTLTAISLDRFLLVIKPVWAQNHRSVLLACLLCGCIWILALLLCLPVFIYRTTV-TDGNHTRCGYDFLVAIT 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 178 eafhlIFEALTGFLLPFLAVVASYSDIGR-RLQARRFRRSRRTGRLVVLIILAFAAFWLPYHVVNLaeaARALAGQASGS 256
Cdd:cd15115  159 -----ITRAVFGFLLPLLIIAACYSFIAFrMQRGRFAKSQSKTFRVIIAVVVAFFVCWAPYHIIGI---LSLYGDPPLSK 230
                        250       260       270
                 ....*....|....*....|....*....|...
gi 966954328 257 GLVgqrlkLARSVLIALAFLSSSVNPVLYACAG 289
Cdd:cd15115  231 VLM-----SWDHLSIALAYANSCLNPVLYVFMG 258
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
19-287 3.83e-33

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 124.33  E-value: 3.83e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  19 LLAIILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCG 98
Cdd:cd14970    1 IVIPAVYSVVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELFLLGLPFLATSYLLGYWPFGEVMCKIVLSVDA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  99 VSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALKTNMSLC---YPKYPSK 175
Cdd:cd14970   81 YNMFTSIFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVLGLPVIIFARTLQEEGGTISCnlqWPDPPDY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 176 EHEAFhLIFEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGR----------LVVLIILAFAAFWLPYHVVNLAEA 245
Cdd:cd14970  161 WGRVF-TIYTFVLGFAVPLLVITVCYSLIIRRLRSSRNLSTSGAREkrrarrkvtrLVLVVVAVFVVCWLPFHVFQIVRL 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 966954328 246 ARALagqasgsglvgQRLKLARSVL---IALAFLSSSVNPVLYAC 287
Cdd:cd14970  240 LIDP-----------PETLTVVGVFlfcIALSYANSCLNPILYAF 273
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
30-290 7.36e-33

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 123.33  E-value: 7.36e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  30 AVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLH-FLAQGTWSFGLAGCRLCHYVCGVSMYASVLLI 108
Cdd:cd15088   12 VVGLVGNGIVLYVLVRCSKLRTAPDIFIFNLAVADLLFMLGMPFLIHqFAIDGQWYFGEVMCKIITALDANNQFTSTYIL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 109 TAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALKTNMSLCYPKYPSKEHEAFHLIFEALT 188
Cdd:cd15088   92 TAMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLWAASFLSILPVWVYSSLIYFPDGTTFCYVSLPSPDDLYWFTIYHFIL 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 189 GFLLPFLAVVASY--------SDIGRRLQARRFRRSRRTGRLVVLIILAFAAFWLPYHVVNLAEAAralAGQASGSGLVG 260
Cdd:cd15088  172 GFAVPLVVITVCYililhrlaRGVAPGNQSHGSSRTKRVTKMVILIVVVFIVCWLPFHVVQLVNLA---MNRPTLAFEVA 248
                        250       260       270
                 ....*....|....*....|....*....|
gi 966954328 261 QRLKlarsvlIALAFLSSSVNPVLYACAGG 290
Cdd:cd15088  249 YFLS------ICLGYANSCLNPFVYILVSE 272
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
23-289 2.72e-32

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 121.94  E-value: 2.72e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  23 ILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGtWSFGLAGCRLCHYVCGVSMY 102
Cdd:cd14984    5 VLYSLVFLLGLVGNSLVLLVLLYYRKLRSMTDVYLLNLALADLLFVLTLPFWAVYAADG-WVFGSFLCKLVSALYTINFY 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 103 ASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALKTNMSlCYPKYPSKEHEA--- 179
Cdd:cd14984   84 SGILFLACISIDRYLAIVHAVSALRARTLLHGKLTCLGVWALALLLSLPEFIFSQVSEENGSSI-CSYDYPEDTATTwkt 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 180 FHLIFEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILAFAAFWLPYHVVNLAEAARALAGQASGSGLv 259
Cdd:cd14984  163 LLRLLQNILGFLLPLLVMLFCYSRIIRTLLRARNHKKHRALRVIFAVVVVFFLCWLPYNIVLLLDTLQLLGIISRSCEL- 241
                        250       260       270
                 ....*....|....*....|....*....|
gi 966954328 260 GQRLKLARSVLIALAFLSSSVNPVLYACAG 289
Cdd:cd14984  242 SKSLDYALQVTESLAFSHCCLNPVLYAFVG 271
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
18-287 5.56e-30

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 116.40  E-value: 5.56e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  18 VLLAIILLSVALaVGLPGNSFVVWSILKR-MKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQG-TWSFGLAGCRLCHY 95
Cdd:cd15190   11 ALIPVIYMLVFV-LGLSGNGLVLWTVFRSkRKRRRSADTFIANLALADLTFVVTLPLWAVYTALGyHWPFGSFLCKLSSY 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  96 VCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVAL-KTNMSLCYPKYP- 173
Cdd:cd15190   90 LVFVNMYASVFCLTGLSFDRYLAIVRSLASAKLRSRTSGIVALGVIWLLAALLALPALILRTTSDLeGTNKVICDMDYSg 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 174 --SKEHEAFHL----IFEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRR-------TGRLVVLIILAFAAFWLPYHVV 240
Cdd:cd15190  170 vvSNESEWAWIaglgLSSTVLGFLLPFLIMLTCYFFIGRTVARHFSKLRRKedkkkrrLLKIIITLVVTFALCWLPFHLV 249
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 966954328 241 NLAEAARALaGQASGSGLVGQRLKLARSVLIALAFLSSSVNPVLYAC 287
Cdd:cd15190  250 KTLYALMYL-GILPFSCGFDLFLMNAHPYATCLAYVNSCLNPFLYAF 295
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
20-285 3.30e-29

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 113.90  E-value: 3.30e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  20 LAIILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLH-FLAQGTWSFGLAGCRLCHYVCG 98
Cdd:cd14982    2 LFPIVYSLIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLFVLTLPFRIYyYLNGGWWPFGDFLCRLTGLLFY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  99 VSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALKTNMSLCYPKYPSKEHE 178
Cdd:cd14982   82 INMYGSILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASVPLLLLRSTIAKENNSTTCFEFLSEWLAS 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 179 AFHLIFEALT-GFLLPFLAVVASYSDI-----GRRLQARRFRRSRRTGRLVVLIILAFAAFWLPYHVVNLAEAARALAGQ 252
Cdd:cd14982  162 AAPIVLIALVvGFLIPLLIILVCYSLIiralrRRSKQSQKSVRKRKALRMILIVLAVFLVCFLPYHVTRILYLLVRLSFI 241
                        250       260       270
                 ....*....|....*....|....*....|...
gi 966954328 253 ASGSglVGQRLKLARSVLIALAFLSSSVNPVLY 285
Cdd:cd14982  242 ADCS--ARNSLYKAYRITLCLASLNSCLDPLIY 272
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
19-285 3.59e-28

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 110.99  E-value: 3.59e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  19 LLAIILLSVALAVGLPGNSFVVWSILKRMKKrSVTALLVLNLALADLAVLLTAPFFLHFLAQG-TWSFGLAGCRLCHYVC 97
Cdd:cd15119    1 IVSIVIYIVAFVLGVPGNAIVIWVTGFKWKK-TVNTLWFLNLAIADFVFVLFLPLHITYVALDfHWPFGVWLCKINSFVA 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  98 GVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALKTNMSLCYPKYPSKEH 177
Cdd:cd15119   80 VLNMFASVLFLTVISLDRYISLAHPVWSHRYRTLKSALILCGIVWLSAAAISGPALYFRDTMELSINVTICFNNFHKHDG 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 178 EAFHLIFEALT------GFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILAFAAFWLPYHVVNLAEAAralag 251
Cdd:cd15119  160 DLIVMRHTILVwvrfffGFLFPLLTMVVCYSLLAIKVKRRTLLISSKFFWTISAVIVAFFVCWTPYHIFSILELS----- 234
                        250       260       270
                 ....*....|....*....|....*....|....
gi 966954328 252 qASGSGLVGQRLKLARSVLIALAFLSSSVNPVLY 285
Cdd:cd15119  235 -IHHSSYLHNVLRAGIPLATSLAFINSCLNPILY 267
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
21-285 9.77e-28

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 109.89  E-value: 9.77e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  21 AIILLSVALAVGLPGNSFVVWSILKRMKkRSVTALLVLNLALADLAVLLTAPFFLHFLAQG-TWSFGLAGCRLCHYVCGV 99
Cdd:cd15118    3 TICLHGIVSTLGIVENLLILWVVGFRLR-RTVISIWILNLALSDLLATLSLPFFTYYLASGhTWELGTTFCRIHSSIFFL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 100 SMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALKTNMSLCYPKY----PSK 175
Cdd:cd15118   82 NMFVSGFLLAAISLDRCLLVVKPVWAQNHRNVAAAKKICGVIWAMALINTIPYFVFRDVIERKDGRKLCYYNFalfsPSP 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 176 EHEAFHL--------IFEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILAFAAFWLPYHVVNLAEAAR 247
Cdd:cd15118  162 DNNHPICkqrqeglaISKLLLAFLIPLVIIAVSYAVVSLIIRHRCRRRPGRFVRLVVSVVVSFALCWAPYHIFSIIEVMA 241
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 966954328 248 alAGQASGSGLVGQRLKLARSvliaLAFLSSSVNPVLY 285
Cdd:cd15118  242 --HNQHSLRPLVIQGLPFATT----LAFLNSVLNPVLY 273
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
22-286 1.06e-27

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 109.29  E-value: 1.06e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  22 IILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALA-DLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVS 100
Cdd:cd15001    3 IIVYVITFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATAdLLLLVFCVPLKTAEYFSPTWSLGAFLCKAVAYLQLLS 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 101 MYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALKTN----MSLCYPKYPSKE 176
Cdd:cd15001   83 FICSVLTLTAISIERYYVILHPMKAKSFCTIGRARKVALLIWILSAILASPVLFGQGLVRYESEngvtVYHCQKAWPSTL 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 177 HEAFHLIFEALTGFLLPFLAVVASYSDIGrrlqarrfrrSRRTGRLVVLIILAFAAFWLPYHVVNLAEAARALagqasgS 256
Cdd:cd15001  163 YSRLYVVYLAIVIFFIPLIVMTFAYARDT----------RKQVIKMLISVVVLFAVCWGPLLIDNLLVSFDVI------S 226
                        250       260       270
                 ....*....|....*....|....*....|
gi 966954328 257 GLVGQRLKLARSVLIALAFLSSSVNPVLYA 286
Cdd:cd15001  227 TLHTQALKYMRIAFHLLSYANSCINPIIYA 256
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
19-289 1.12e-26

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 106.77  E-value: 1.12e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  19 LLAIILLSVALAVGLPGNSFVVWSILKRMKKrSVTALLVLNLALADLAVLLTAPFFLHFLAQGT-WSFGLAGCRLCHYVC 97
Cdd:cd15116    1 ILSMVIYSVVFVLGVLGNGLVIFITGFKMKK-TVNTVWFLNLAVADFLFTFFLPFSIAYTAMDFhWPFGRFMCKLNSFLL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  98 GVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYR-TVVALKTNMSLCYPKY---- 172
Cdd:cd15116   80 FLNMFTSVFLLTVISIDRCISVVFPVWSQNHRSVRLASLVSLAVWVVAFFLSSPSFIFRdTAPSQNNNKIICFNNFslsg 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 173 PSKEHEAFHL---------IFEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILAFAAFWLPYHVVNLA 243
Cdd:cd15116  160 DNSSPEVNQLrnmrhqvmtITRFLLGFLIPFTIIICCYAAIVLKLKRNRLAKSSKPFKIIAAVIVTFFLCWAPYHILNLL 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 966954328 244 EAARALAgqasgsglVGQRLKLARSVLIALAFLSSSVNPVLYACAG 289
Cdd:cd15116  240 EMEATRS--------PASVFKIGLPITSSLAFINSCLNPILYVFMG 277
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
82-286 3.28e-26

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 105.58  E-value: 3.28e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  82 TWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVV-- 159
Cdd:cd15098   67 EWVFGAFMCKFVHYFFTVSMLVSIFTLVAMSVDRYIAVVHSRTSSSLRTRRNALLGVLVIWVLSLAMASPVAVHQDLVhh 146
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 160 ALKTNMSLCYPKYPSKEHEAFHLIFEALTGFLLPFLAVVASYSDI-------GRRLQARRFRRSRRTGRLVVLIILAFAA 232
Cdd:cd15098  147 WTASNQTFCWENWPEKQQKPVYVVCTFVFGYLLPLLLITFCYAKVlnhlhkkLKNMSKKSERSKKKTAQTVLVVVVVFGI 226
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 966954328 233 FWLPYHVVNL-AEAARALAGQASgsglvgqrlKLARSVLIALAFLSSSVNPVLYA 286
Cdd:cd15098  227 SWLPHHIIHLwVEFGDFPLTQAS---------FVLRITAHCLAYANSCVNPIIYA 272
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
23-286 6.01e-26

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 104.83  E-value: 6.01e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  23 ILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQG-TWSFGLAGCRLCHYVCGVSM 101
Cdd:cd15193    5 ILYLIIFFTGLLGNLFVIALMSKRSTTKRLVDTFVLNLAVADLVFVLTLPFWAASTALGgQWLFGEGLCKLSSFIIAVNR 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 102 YASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVValktNMSLCYPKYPSKEHEAFH 181
Cdd:cd15193   85 CSSILFLTGMSVDRYLAVVKLLDSRPLRTRRCALITCCIIWAVSLVLGIPSLVYRNLI----NESVCVEDSSSRFFQGIS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 182 LIFEALTgFLLPFLAVVASYSDIGR------RLQARRFRRSRRTGRLVVLIILAFAAFWLPYhvvNLAEAARALAGQASG 255
Cdd:cd15193  161 LATLFLT-FVLPLIVILFCYCSILVrlrrhfHGAKRTGRRRRNSLRIVFAIVTAFVLSWLPF---NTLKAVRLLLELGGG 236
                        250       260       270
                 ....*....|....*....|....*....|...
gi 966954328 256 SGLVGQRLKLARSVLIA--LAFLSSSVNPVLYA 286
Cdd:cd15193  237 VLPCHTTVAIRQGLTITacLAFVNSCVNPLIYS 269
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
22-286 7.09e-26

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 104.99  E-value: 7.09e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  22 IILLSVALAVGLPGNSFVVWSILKRMKKRSVTAllvlnlaladlavlltapFFLHFLA-------------------QGT 82
Cdd:cd14993    4 IVLYVVVFLLALVGNSLVIAVVLRNKHMRTVTN------------------YFLVNLAvadllvslfcmpltllenvYRP 65
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  83 WSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALK 162
Cdd:cd14993   66 WVFGEVLCKAVPYLQGVSVSASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIIIMLPLLVVYELEEII 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 163 TNMS------LCYPKYPSKEHEAFHLIFEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGR--------------- 221
Cdd:cd14993  146 SSEPgtitiyICTEDWPSPELRKAYNVALFVVLYVLPLLIISVAYSLIGRRLWRRKPPGDRGSANstssrrilrskkkva 225
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966954328 222 -LVVLIILAFAAFWLPYHVVNLAEAARALAGQASGSGlvgqrLKLARSVLIALAFLSSSVNPVLYA 286
Cdd:cd14993  226 rMLIVVVVLFALSWLPYYVLSILLDFGPLSSEESDEN-----FLLILPFAQLLGYSNSAINPIIYC 286
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
19-285 7.29e-26

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 104.77  E-value: 7.29e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  19 LLAIILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQG-TWSFGLAGCRLCHYVC 97
Cdd:cd15160    1 IFLPVVYSFVFVVGLPANCLALWVLYLQIKKENVLGVYLLNLSLSDLLYILTLPLWIDYTANHhNWTFGPLSCKVVGFFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  98 GVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALKTNMSLCYPKYPSKEH 177
Cdd:cd15160   81 YTNIYASIGFLCCIAVDRYLAVVHPLRFRGLRTRRFALKVSASIWVLELGTHSVFLGHDELFRDEPNHTLCYEKYPMEGW 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 178 EAFHLIFEALTGFLLPFLAVVASYSDIGRRLQARRFRRS---RRTGRLVVLIILAFAAFWLPYHVVNLAEAARALAgqAS 254
Cdd:cd15160  161 QASYNYARFLVGFLIPLSLILFFYRRVLRAVRQSPSLEReekRKIIGLLLSIVVIFLLCFLPYHVVLLVRSVIELV--QN 238
                        250       260       270
                 ....*....|....*....|....*....|.
gi 966954328 255 GSGLVGQRLKLARSVLIALAFLSSSVNPVLY 285
Cdd:cd15160  239 GLCGFEKRVFTAYQISLCLTSLNCVADPILY 269
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
23-289 1.92e-25

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 103.55  E-value: 1.92e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  23 ILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGT-WSFGLAGCRLCHYVCGVSM 101
Cdd:cd15168    5 IVYGVVFLVGLLLNSVVLYRFIFHLKPWNSSAIYMFNLAVSDLLYLLSLPFLIYYYANGDhWIFGDFMCKLVRFLFYFNL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 102 YASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVAlKTNMSLCYPKYPSKEHEAFH 181
Cdd:cd15168   85 YGSILFLTCISVHRYLGICHPLRSLGKLKKRHAVAISVAVWILVLLQLLPILFFATTGR-KNNRTTCYDTTSPEELNDYV 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 182 L--IFEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTG-----RLVVLIILAFAAFWLPYHVV-NLAEAARALAGQA 253
Cdd:cd15168  164 IysMVLTGLGFLLPLLIILACYGLIVRALIRKLGEGVTSALrrksiRLVIIVLALFAVCFLPFHVTrTINLAARLLSGTA 243
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 966954328 254 SGSGLVGqrLKLARSVLIALAFLSSSVNPVLYACAG 289
Cdd:cd15168  244 SCATLNG--IYVAYKVTRPLASLNSCLNPLLYFLAG 277
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
23-286 4.20e-25

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 102.76  E-value: 4.20e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  23 ILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALA-DLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVSM 101
Cdd:cd15096    5 VIFGLIFIVGLIGNSLVILVVLSNQQMRSTTNILILNLAVAdLLFVVFCVPFTATDYVLPTWPFGDVWCKIVQYLVYVTA 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 102 YASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLV-YRTVVALKTNMSLCYPKYPSKEHEAF 180
Cdd:cd15096   85 YASVYTLVLMSLDRYLAVVHPITSMSIRTERNTLIAIVGIWIVILVANIPVLFlHGVVSYGFSSEAYSYCTFLTEVGTAA 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 181 HLIFEA--LTGFLLPFLAVVASYSDI----------GRRLQARRFRRSRRTGRLVVLIILAFAAFWLPYHVVNLAEaarA 248
Cdd:cd15096  165 QTFFTSffLFSYLIPLTLICVLYMLMlrrlrrqkspGGRRSAESQRGKRRVTRLVVVVVVVFAICWLPIHIILLLK---Y 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 966954328 249 LAGQASGsglvgqrlKLARSVLIA---LAFLSSSVNPVLYA 286
Cdd:cd15096  242 YGVLPET--------VLYVVIQILsncLAYGNSCVNPILYA 274
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
19-239 2.08e-24

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 100.63  E-value: 2.08e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  19 LLAIILLSVALAVGLPGNSFVVWsILKRMKKRSVTALLVLNLALADLAVLLTAPFF-LHFLAQGTWSFGLAGCRLCHYVC 97
Cdd:cd15120    1 VLIAVALFVTFLVGLVVNGLYLW-VLGFKMRRTVNTLWFLHLILSNLIFTLILPFMaVHVLMDNHWAFGTVLCKVLNSTL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  98 GVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALKTNMSLCYPKY----- 172
Cdd:cd15120   80 SVGMFTSVFLLTAISLDRYLLTLHPVWSRQHRTNRWASAIVLGVWISAILLSIPYLAFRETRLDEKGKTICQNNYalstn 159
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966954328 173 -PSKEHEAFH-------LIFEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILAFAAFWLPYHV 239
Cdd:cd15120  160 wESAEVQASRqwihvamFVFRFLLGFLLPFLIITFCYVRMALKMKERGLARSSKPFKVMFTAVVSFFVCWLPYHL 234
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
18-289 8.62e-24

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 99.28  E-value: 8.62e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  18 VLLAIILLsvalaVGLPGNSFVVWSILKRMKKRSVTALLVLNLALA-DLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYV 96
Cdd:cd15095    5 LIFAIIFL-----VGLAGNSLVIYVVSRHREMRTVTNYYIVNLAVTdLAFLVCCVPFTAALYATPSWVFGDFMCKFVNYM 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  97 CGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALKTN--MSLCYPKYPS 174
Cdd:cd15095   80 MQVTVQATCLTLTALSVDRYYAIVHPIRSLRFRTPRVAVVVSACIWIVSFLLSIPVAIYYRLEEGYWYgpQTYCREVWPS 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 175 KEHEAFHLIFEALTGFLLPFLAVVASYSDI--------------GRRLQARRFRRSRRTGRLVVLIILAFAAFWLPYHVV 240
Cdd:cd15095  160 KAFQKAYMIYTVLLTYVIPLAIIAVCYGLIlrrlwrrsvdgnnqSEQLSERALRQKRKVTRMVIVVVVLFAICWLPNHVL 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 966954328 241 NLaeaARALAGQASGSGLVGQrLKLArsvLIALAFLSSSVNPVLYACAG 289
Cdd:cd15095  240 NL---WQRFDPNFPETYATYA-LKIA---ALCLSYANSAVNPFVYAFMG 281
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
18-286 1.15e-23

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 98.69  E-value: 1.15e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  18 VLLAIILLSVALaVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVC 97
Cdd:cd15093    1 VLIPCIYAVVCL-VGLCGNSLVIYVVLRYAKMKTVTNIYILNLAIADELFMLGLPFLAASNALRHWPFGSVLCRLVLSVD 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  98 GVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALKTNMSLCYPKYPSKEH 177
Cdd:cd15093   80 GINMFTSIFCLTVMSVDRYLAVVHPIKSARWRRPRVAKVVNLAVWVASLLVILPVVVFAGTRENQDGSSACNMQWPEPAA 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 178 --EAFHLIFEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRR--------TGRLVVLIILAFAAFWLPYHVVNLAEAAR 247
Cdd:cd15093  160 awSAGFIIYTFVLGFLLPLLIICLCYLLIVIKVKSAGLRAGWQqrkrserkVTRMVVMVVVVFVICWLPFYVLQLVNVFV 239
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 966954328 248 ALAgqasgsglVGQRLKLARSVLIALAFLSSSVNPVLYA 286
Cdd:cd15093  240 QLP--------ETPALVGVYHFVVILSYANSCANPILYG 270
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
72-287 7.39e-23

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 95.71  E-value: 7.39e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  72 PFFLHFLAQGTWSFGLAGCRL---CHYVCGVsmyASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLL 148
Cdd:cd14967   54 PFSAVYTLLGYWPFGPVLCRFwiaLDVLCCT---ASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLI 130
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 149 ATPVLVYRTVVALKTNMSLCYPKYPSKEheafHLIFEALTGFLLPFLAVVASYSDIgrrlqARRFRRSRRTGRLVVLIIL 228
Cdd:cd14967  131 SLPPLVGWRDETQPSVVDCECEFTPNKI----YVLVSSVISFFIPLLIMIVLYARI-----FRVARRELKAAKTLAIIVG 201
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 966954328 229 AFAAFWLPYHVVNLAEAARalagqasGSGLVgqrLKLARSVLIALAFLSSSVNPVLYAC 287
Cdd:cd14967  202 AFLLCWLPFFIIYLVSAFC-------PPDCV---PPILYAVFFWLGYLNSALNPIIYAL 250
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
24-285 2.91e-22

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 94.88  E-value: 2.91e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  24 LLSVALAVGLPGNSFVVWSILkRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQG-TWSFGLAGCRLCHYVCGVSMY 102
Cdd:cd15339    6 FIGILCSTGLVGNILVLFTII-RSRKKTVPDIYVCNLAVADLVHIIVMPFLIHQWARGgEWVFGSPLCTIITSLDTCNQF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 103 ASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALKTNMSLCYPKYPSKEHEAFHL 182
Cdd:cd15339   85 ACSAIMTAMSLDRYIALVHPFRLTSLRTRSKTIRINLLVWAASFILVLPVWVYAKVIKFRDGLESCAFNLTSPDDVLWYT 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 183 IFEALTGFLLPFLAVVASYS--------------DIGRRLQARRFRRSRRTGRLVVLIILAFAAFWLPYHV---VNLAEA 245
Cdd:cd15339  165 LYQTITTFFFPLPLILICYIlilcytwemyrknkKAGRYNTSIPRQRVMRLTKMVLVLVGVFLVSAAPYHViqlVNLSVS 244
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 966954328 246 ARALAgqasgsglvgqrLKLARSVLIALAFLSSSVNPVLY 285
Cdd:cd15339  245 QPTLA------------FYVSYYLSICLSYASSSINPFLY 272
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
23-286 2.92e-22

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 94.84  E-value: 2.92e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  23 ILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALA-DLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVSM 101
Cdd:cd14971    5 LFFALIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVAdLTFLLFCVPFTATIYPLPGWVFGDFMCKFVHYFQQVSM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 102 YASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVL-VYRTVVALKTNMSLCYPKYPSKEHEAF 180
Cdd:cd14971   85 HASIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVAAPVLaLHRLRNYTPGNRTVCSEAWPSRAHRRA 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 181 HLIFEALTGFLLPFLAVVASY---------SDIGRRLQARRFRRSRRTGRLVVLIILAFAAFWLPYHVVNLAeaaralag 251
Cdd:cd14971  165 FALCTFLFGYLLPLLLICVCYaamlrhlwrVAVRPVLSEGSRRAKRKVTRLVLVVVVLFAACWGPIHAILLL-------- 236
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 966954328 252 QASGSGLVGQRLKLARSVLIALAFLSSSVNPVLYA 286
Cdd:cd14971  237 VALGPFPLTYATYALRIWAHCLAYSNSAVNPVLYA 271
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
23-296 4.51e-22

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 94.06  E-value: 4.51e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  23 ILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFlHFLAQGTWSFGLAGCRLCHYVCGVSMY 102
Cdd:cd15179    5 TVYSIIFLLGIVGNGLVILVMGYQKKSRTMTDKYRLHLSVADLLFVLTLPFW-AVDAAANWYFGNFLCKAVHVIYTVNLY 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 103 ASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALkTNMSLCYPKYPSKEHEAFHL 182
Cdd:cd15179   84 SSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWLPALLLTVPDLVFAKVSEL-DDRYICDRIYPEDTFELWVV 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 183 IFEA---LTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILAFAAFWLPYHVVNLAEAARALAGQASGSGLv 259
Cdd:cd15179  163 AFRFqhiLVGLVLPGLVILTCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDTFMLLEIIKQSCEM- 241
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 966954328 260 GQRLKLARSVLIALAFLSSSVNPVLYACAGGGLLRSA 296
Cdd:cd15179  242 EQTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSA 278
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
19-289 1.06e-21

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 93.26  E-value: 1.06e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  19 LLAIILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQG-TWSFGLAGCRLCHYVC 97
Cdd:cd15192    1 IMIPTVYSIIFVVGIFGNSLVVIVIYCYMKLKTVANIFLLNLALADLCFLITLPLWAAYTAMEyHWPFGNFLCKIASALV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  98 GVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALK-TNMSLCYPKYPSKE 176
Cdd:cd15192   81 SFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTLVVARVTCIVIWLLAGVASLPAIIHRDVFFIEnTNITVCAFHYPSQN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 177 HEafHLIFEALT----GFLLPFLAVVASYSDIGRRLQARRFRRSRR-----TGRLVVLIILAFAAFWLPYHVVNLAEAAR 247
Cdd:cd15192  161 ST--LLVGLGLMknllGFLIPFLIILTCYTLIGKALKKAYEIQRNKprndeIFKMIMAVVLFFFFCWIPHQIFTFLDVLI 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 966954328 248 ALagQASGSGLVGQRLKLARSVLIALAFLSSSVNPVLYACAG 289
Cdd:cd15192  239 QL--KVIQDCHIADIVDTAMPFTICIAYFNSCLNPILYGFVG 278
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
19-289 1.35e-21

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 92.94  E-value: 1.35e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  19 LLAIILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQgTWSFGLAGCRLCHYVCG 98
Cdd:cd15187    1 LFLPVLYCLLFVFGLLGNSLVIWVLVACKKLRSMTDVYLLNLAASDLLFVFSLPFQAYYLLD-QWVFGNAMCKIVSGAYY 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  99 VSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVAlKTNMSLCYPKYP--SKE 176
Cdd:cd15187   80 IGFYSSMFFITLMSIDRYLAIVHAVYALKVRTASHGTILSLALWLVAILASVPLLVFYQVAS-EDGRLQCIPFYPgqGNS 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 177 HEAFHLIFEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILAFAAFWLPYHVVNLAEAARAL----AGQ 252
Cdd:cd15187  159 WKVFTNFEVNILGLLIPFSILIFCYHNILRNLRRCHNQNKTKAIKLVFIVVIVFFLFWTPFNVVLFLDSLHSLhiidGCQ 238
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 966954328 253 ASgsglvgQRLKLARSVLIALAFLSSSVNPVLYACAG 289
Cdd:cd15187  239 NS------QRLTLALHLTETISFTHCCLNPVIYAFVG 269
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
20-289 3.28e-21

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 92.10  E-value: 3.28e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  20 LAIILLSVALAVGLPGNSFVVWSILKRMKkRSVTALLVLNLALADLAVLLTAPFFLHFLAQG-TWSFGLAGCRLCHYVCG 98
Cdd:cd15117    2 LSLVIYSSAFVLGTLGNGLVIWVTGFRMT-RTVTTVCFLNLAVADFAFCLFLPFSVVYTALGfHWPFGWFLCKLYSTLVV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  99 VSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVAlKTNMSLCYPKYPS---- 174
Cdd:cd15117   81 FNLFASVFLLTLISLDRCVSVLWPVWARNHRTPARAALVAVGAWLLALALSGPHLVFRDTRK-ENGCTHCYLNFDPwnet 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 175 -------KEHEAFHLIFEALT----GFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILAFAAFWLPYHVVNLA 243
Cdd:cd15117  160 aedpvlwLETVVQRLSAQVITrfvlGFLVPLVIIGGCYGLIAARLWREGWVHSSRPFRVLTAVVAAFFLCWFPFHLVSLL 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 966954328 244 EAARALaGQASGsglVGQRLKLARSVLIALAFLSSSVNPVLYACAG 289
Cdd:cd15117  240 ELVVIL-NQKED---LNPLLILLLPLSSSLACVNSCLNPLLYVFVG 281
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
22-286 3.53e-21

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 91.90  E-value: 3.53e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  22 IILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALA-DLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVS 100
Cdd:cd15203    4 ILLYGLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSdLLLCLVSLPFTLIYTLTKNWPFGSILCKLVPSLQGVS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 101 MYASVLLITAMSLDRSLAVARPFvSQKLRTKaMALRVLAGIWVVSFLLATPVLVYRTVVALKTNM-----SLCYPKYPSK 175
Cdd:cd15203   84 IFVSTLTLTAIAIDRYQLIVYPT-RPRMSKR-HALLIIALIWILSLLLSLPLAIFQELSDVPIEIlpycgYFCTESWPSS 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 176 EHEAFHLIFEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGR-----------------LVVLIILAFAAFWLPYH 238
Cdd:cd15203  162 SSRLIYTISVLVLQFVIPLLIISFCYFRISLKLRKRVKKKRGKRTLssrrrrselrrkrrtnrLLIAMVVVFAVCWLPLN 241
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 966954328 239 VVNLaeaARALAGQASGSG----LVGQRLKLarsvliaLAFLSSSVNPVLYA 286
Cdd:cd15203  242 LFNL---LRDFEPLPQIDGrhfyLIFLICHL-------IAMSSACVNPLLYG 283
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
18-285 3.70e-21

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 91.79  E-value: 3.70e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  18 VLLAIILLSVAlAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVC 97
Cdd:cd15974    1 VLIPVIYLLVC-AIGLSGNTLVIYVVLRYAKMKTVTNIYILNLAVADELFMLGLPFLATQNAISYWPFGSFLCRLVMTVD 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  98 GVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALKTNMSLCYPKYPSKEH 177
Cdd:cd15974   80 GVNQFTSIFCLTVMSIDRYLAVVHPIKSTKWRRPRVAKLINATVWTLSFLVVLPVIIFSDVQPDLNTCNISWPEPVSVWS 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 178 EAFhLIFEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRR--------TGRLVVLIILAFAAFWLPYHVVNLAEAARAL 249
Cdd:cd15974  160 TAF-IIYTAVLGFFGPLLVICLCYLLIVIKVKSSGLRVGSTkrrkserkVTRMVVIIVVVFVFCWLPFYMLNIVNLIVIL 238
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 966954328 250 AGQASGSGLVgqrlklarSVLIALAFLSSSVNPVLY 285
Cdd:cd15974  239 PEEPAFVGVY--------FFVVVLSYANSCANPILY 266
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
26-295 5.72e-21

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 91.13  E-value: 5.72e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  26 SVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYASV 105
Cdd:cd15970    8 SVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLVTSTLLRHWPFGSLLCRLVLSVDAINMFTSI 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 106 LLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALKTNMSLCYPKYPSKEHE--AFHLI 183
Cdd:cd15970   88 YCLTVLSIDRYIAVVHPIKAARYRRPTVAKMVNLGVWVFSILVILPIIIFSNTAPNSDGSVACNMQMPEPSQRwlAVFVV 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 184 FEALTGFLLPFLAVVASYSDIGRRLQARRFRR--------SRRTGRLVVLIILAFAAFWLPYHVVNLAEAaralagqasg 255
Cdd:cd15970  168 YTFLMGFLLPVIAICLCYILIIVKMRVVALKAgwqqrkrsERKITLMVMMVVTVFVICWMPFYVVQLVSV---------- 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 966954328 256 sgLVGQRLKLARSVLIALAFLSSSVNPVLYACAGGGLLRS 295
Cdd:cd15970  238 --FVGQHDATVSQLSVILGYANSCANPILYGFLSDNFKRS 275
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
32-289 8.15e-21

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 90.99  E-value: 8.15e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  32 GLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFF-LHFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITA 110
Cdd:cd15189   14 GLLGNLFVLLVFLLHRRRLTVAEIYLGNLAAADLVFVSGLPFWaMNILNQFNWPFGELLCRVVNGVIKVNLYTSIYLLVM 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 111 MSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALKT-NMSLCYPKYPSKEHEAFHLIFEALTG 189
Cdd:cd15189   94 ISQDRYLALVKTMAARRLRRRRYAKLICVLIWVVGLLLSIPTFLLRKIKAIPDlNITACVLLYPHEAWHFAHIVLLNIVG 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 190 FLLPFLAVVASYSDIGRRLQARRFRRS------RRTGRLVVLIILAFAAFWLPYHVVNLAEAARALagQASGSGLVGQRL 263
Cdd:cd15189  174 FLLPLLVITFCNYNILQALRTREESTRcedrndSKATALVLAVTLLFLVCWGPYHFFTFLDFLFDV--GVLDECFWEHFI 251
                        250       260
                 ....*....|....*....|....*.
gi 966954328 264 KLARSVLIALAFLSSSVNPVLYACAG 289
Cdd:cd15189  252 DIGLQLAVFLAFSNSCLNPVLYVFVG 277
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
23-289 1.22e-20

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 90.19  E-value: 1.22e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  23 ILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQG-TWSFGLAGCRLCHYVCGVSM 101
Cdd:cd15191    5 VLYSIIFILGFLGNSLVVCVFCHQSGPKTVASIYIFNLAVADLLFLATLPLWATYYSYGyNWLFGSVMCKICGSLLTLNL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 102 YASVLLITAMSLDRSLAVARPFVSQKlRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALKT-NMSLCYPKYPSKEHEAF 180
Cdd:cd15191   85 FASIFFITCMSVDRYLAVVYPLRSQR-RRSWQARLVCLLVWVLACLSSLPTFYFRDTYYIEElGVNACIMAFPNEKYAQW 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 181 HL---IFEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGR-----LVVLIILAFAAFWLPYHVVNLAEAARALagQ 252
Cdd:cd15191  164 SAglaLMKNTLGFLIPLIVIATCYFGIGRHLLKTKGFGKNKQRRdkvlkMVAAVVLAFLICWFPFHVLTFLDALARM--G 241
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 966954328 253 ASGSGLVGQRLKLARSVLIALAFLSSSVNPVLYACAG 289
Cdd:cd15191  242 VINNCWVITVIDKALPFAICLGFSNSCINPFLYCFVG 278
7tmA_ACKR2_D6 cd15188
atypical chemokine receptor 2, member of the class A family of seven-transmembrane G ...
23-286 2.52e-20

atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR2 (also known as D6) binds non-selectively to all inflammatory CC-chemokines, but not to homeostatic CC-chemokines involved in controlling the migration of cells. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320316 [Multi-domain]  Cd Length: 278  Bit Score: 89.46  E-value: 2.52e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  23 ILLSVALAVGLPGNSFVVWSILKRM-KKRSVTALLVLNLALADLAVLLTAPFFLHFLAQgTWSFGLAGCRLCHYVCGVSM 101
Cdd:cd15188    5 VFYTLVFLLGLAGNLLLFVVLLLYVpKKKKMTEVYLLNLAVSDLLFLVTLPFWAMYVAW-HWVFGSFLCKFVSTLYTINF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 102 YASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALKTNMSLCYPKYpSKEHEAFH 181
Cdd:cd15188   84 YSGIFFVSCMSLDKYLEIVHAQSPHRLRTRRKSLLVLVAVWVLSIALSVPDMVFVQTHHTNNGVWVCHADY-GGHHTIWK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 182 LIF---EALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILAFAAFWLPYHVVNLAEAARALagQASGSGL 258
Cdd:cd15188  163 LVFqfqQNLLGFLFPLLAMVFFYSRIACVLTRLRPPGQGRALRFVAALVVVFFVLWFPYNLTLFLHSLQDL--HVIGNCE 240
                        250       260
                 ....*....|....*....|....*...
gi 966954328 259 VGQRLKLARSVLIALAFLSSSVNPVLYA 286
Cdd:cd15188  241 RSRHLDYALQVTESLAFVHCCLNPLLYA 268
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
26-287 4.85e-20

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 88.45  E-value: 4.85e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  26 SVALAVGLPGNSFVVWSIL--KRMKKRSVTALLVLNLALADLAVLLTAPFFLhFLAQGTWSFGLAGCRLCHYVCGVSMYA 103
Cdd:cd16003    8 GFVVAVAVFGNLIVIWIILahKRMRTVTNYFLVNLAFSDASMAAFNTLINFI-YALHSEWYFGEAYCRFHNFFPITSVFA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 104 SVLLITAMSLDRSLAVARPFvsqKLRTKAMALRVLAG-IWVVSFLLATPVLVYRTVVALKTNmSLCYPKYP--SKEHEAF 180
Cdd:cd16003   87 SIYSMTAIAVDRYMAIIDPL---KPRLSATATKVVIGsIWILAFLLAFPQCLYSKTKVMPGR-TLCFVAWPggPDQHFTY 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 181 HLIFEALTgFLLPFLAVVASYSDIGRRL------------QARRFRRSRRTGRLVVLIILAFAAFWLPYHVVNLAEaarA 248
Cdd:cd16003  163 HIIVIVLV-YCLPLLVMGITYTIVGITLwggeipgdtsdkYHEQLRAKRKVVKMMIIVVLTFAICWLPYHIYFIVT---G 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 966954328 249 LAGQASgsglvgqRLKLARSVLIA---LAFLSSSVNPVLYAC 287
Cdd:cd16003  239 LYQQLN-------RWKYIQQVYLAsfwLAMSSTMYNPIIYCC 273
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
18-286 5.15e-20

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 88.32  E-value: 5.15e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  18 VLLAIILLsVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVC 97
Cdd:cd15972    1 VLIPLVYL-VVCVVGLGGNTLVIYVVLRYSASESVTNIYILNLALADELFMLGLPFLAAQNALSYWPFGSFMCRLVMTVD 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  98 GVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALKTNMSLCYPKyPSKEH 177
Cdd:cd15972   80 AINQFTSIFCLTVMSVDRYLAVVHPIRSSKWRKPPVAKTVNATVWALSFLVVLPVVIFSGVPGGMGTCHIAWPE-PAQVW 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 178 EAFHLIFEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRT----------GRLVVLIILAFAAFWLPYHVVNLAEAAR 247
Cdd:cd15972  159 RAGFIIYTATLGFFCPLLVICLCYLLIVVKVRSSGRRVRATStkrrgserkvTRMVVIVVAAFVLCWLPFYALNIVNLVC 238
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 966954328 248 ALAGQASGSGLVgqrlklarSVLIALAFLSSSVNPVLYA 286
Cdd:cd15972  239 PLPEEPSLFGLY--------FFVVVLSYANSCANPIIYG 269
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
24-285 5.62e-20

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 88.27  E-value: 5.62e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  24 LLSVALAVGLPGNSFVVWSILKRMKK-RSVTALLVLNLALADLAVLLTAPFFLHFLAQgTWSFGLAGCRLCHYVCGVSMY 102
Cdd:cd15372    6 LYTLVFLVGLPANGLALWVLATQVKRlPSTIFLINLAVADLLLILVLPFKISYHFLGN-NWPFGEGLCRVVTAFFYGNMY 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 103 ASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYR-TVVALKTNMSLCYPKYPSKE---HE 178
Cdd:cd15372   85 CSVLLLMCISLDRYLAVVHPFFARTLRSRRFALCMCTAIWLIAAALTLPLTLQRqSYPLERLNITLCHDVLPLDEqdtYL 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 179 AFHLIFEALTGFLLPFLAVVASYSDIgRRLQARRFRRSRRTGRLVVLIILAFAAFWLPYHVVNLAEAARAlagQASGSGL 258
Cdd:cd15372  165 FYYFACLAVLGFLLPLVVILFCYGSV-LHTLLRSGQRYGHAMKLTVLVLVSFVLCFTPSNLLLLLHYSDP---TLDDGGN 240
                        250       260
                 ....*....|....*....|....*..
gi 966954328 259 vgqrLKLARSVLIALAFLSSSVNPVLY 285
Cdd:cd15372  241 ----LYIVYMVSLAISTLNSCVDPFIY 263
7tmA_CX3CR1 cd15186
CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G ...
23-289 1.24e-19

CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CX3CR1 is an inflammatory receptor specific for CX3CL1 (also known as fractalkine in human), which is involved in the adhesion and migration of leukocytes. The CX3C chemokine subfamily is only represented by CX3CL1, which exists in both soluble and membrane-anchored forms. Membrane-anchored form promotes strong adhesion of receptor-bearing leukocytes to CX3CL1-expressing endothelial cells. On the other hand, soluble CX3CL1, which is released by the proteolytic cleavage of membrane-anchored CX3CL1, is a potent chemoattractant for CX3CR1-expressing T cells and monocytes. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 320314 [Multi-domain]  Cd Length: 273  Bit Score: 87.20  E-value: 1.24e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  23 ILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGtWSFGLAGCRLCHYVCGVSMY 102
Cdd:cd15186    5 IFYSLVFAFGLVGNLLVVLALTNSGKSKSITDIYLLNLALSDLLFVATLPFWTHYLINE-WGLHNAMCKLTTAFFFIGFF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 103 ASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRtvvalKTNMSLCYPKYPSKEHEAFHL 182
Cdd:cd15186   84 GGIFFITVISIDRYLAIVLAANSMNNRTVQHGVTISLGVWAAAILVAVPQFMFT-----KMKENECLGDYPEVLQEIWPV 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 183 IFEA---LTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILAFAAFWLPYHVVNLAEAARALAGQASGSglV 259
Cdd:cd15186  159 LRNVelnFLGFLLPLLIMSYCYFRIIQTLFSCKNHKKARAIKLILLVVIVFFLFWTPYNVMIFLETLKLYDFFPSCD--M 236
                        250       260       270
                 ....*....|....*....|....*....|
gi 966954328 260 GQRLKLARSVLIALAFLSSSVNPVLYACAG 289
Cdd:cd15186  237 KKDLRLALSVTETIAFSHCCLNPLIYAFAG 266
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
23-289 1.35e-19

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 87.11  E-value: 1.35e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  23 ILLSVALAVGLPGNSFVV--WSILKRMkkRSVTALLVLNLALADLAVLLTAPFFLHFLAQGtWSFGLAGCRLCHYVCGVS 100
Cdd:cd15176    5 VFYTIALVVGLAGNSLVVaiYAYYKKL--KTKTDVYILNLAVADLLLLFTLPFWAADAVNG-WVLGTAMCKITSALYTMN 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 101 MYASVLLITAMSLDRSLAVARpfVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVvALKTNMSLCYPKYPS---KEH 177
Cdd:cd15176   82 FSCGMQFLACISVDRYVAITK--ATSRQFTGKHCWIVCLCVWLLAILLSIPDLVFSTV-RENSDRYRCLPVFPPslvTSA 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 178 EAFHLIFEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILAFAAFWLPYHVVNLAEA---ARALAGQAS 254
Cdd:cd15176  159 KATIQILEVLLGFVLPFLVMVFCYSRVARALSRTPNVKKSRALKVLLAVVGVFIVTQLPYNVVKFYRAidvIYLLITDCS 238
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 966954328 255 GSglvgQRLKLARSVLIALAFLSSSVNPVLYACAG 289
Cdd:cd15176  239 MS----KTLDIAIQVTESIALFHSCLNPVLYVFMG 269
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
22-288 1.69e-19

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 87.35  E-value: 1.69e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  22 IILLSVALAVGLPGNSFVVWSIL--KRMkkRSVTALLVLNLALA-DLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCG 98
Cdd:cd15390    4 SIVFVVMVLVAIGGNLIVIWIVLahKRM--RTVTNYFLVNLAVAdLLISAFNTVFNFTYLLYNDWPFGLFYCKFSNFVAI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  99 VSMYASVLLITAMSLDRSLAVARPFvsQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALKTNMS----LCYPKYP- 173
Cdd:cd15390   82 TTVAASVFTLMAISIDRYIAIVHPL--RPRLSRRTTKIAIAVIWLASFLLALPQLLYSTTETYYYYTGsertVCFIAWPd 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 174 ---SKEHEAFHLIFEALTgFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRL------------VVLIILAFAAFWLPYH 238
Cdd:cd15390  160 gpnSLQDFVYNIVLFVVT-YFLPLIIMAVAYTRVGVELWGSKTIGENTPRQLesvrakrkvvkmMIVVVVIFAICWLPYH 238
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 966954328 239 VVNLAEAARALAGQAsgsglvgqrlKLARSVLIA---LAFLSSSVNPVLYACA 288
Cdd:cd15390  239 LYFILTYLYPDINSW----------KYIQQIYLAiywLAMSNSMYNPIIYCWM 281
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
27-286 1.76e-19

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 86.82  E-value: 1.76e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  27 VALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYASVL 106
Cdd:cd15971    9 VVCIIGLCGNTLVIYVILRYAKMKTVTNIYILNLAIADELFMLGLPFLAIQVALVHWPFGKAICRVVMTVDGINQFTSIF 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 107 LITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVAL--KTNMSLCYPKYPSKEHEAFhLIF 184
Cdd:cd15971   89 CLTVMSIDRYLAVVHPIKSAKWRKPRTAKMINMAVWGVSLLVILPIMIYAGVQTKhgRSSCTIIWPGESSAWYTGF-IIY 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 185 EALTGFLLP-------FLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILAFAAF-WLPYHVVNLAEAARALAGQASgs 256
Cdd:cd15971  168 TFILGFFVPltiiclcYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFVFcWLPFYIFNVSSVSVSISPTPG-- 245
                        250       260       270
                 ....*....|....*....|....*....|
gi 966954328 257 glvgqrLKLARSVLIALAFLSSSVNPVLYA 286
Cdd:cd15971  246 ------LKGMFDFVVVLSYANSCANPILYA 269
7tmA_CCR6 cd15172
CC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
19-289 5.15e-19

CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR6 is the only known receptor identified for the chemokine CCL20 (also known as macrophage inflammatory protein-3alpha, MIP-3alpha). CCR6 is expressed by all mature human B cells, effector memory T-cells, and dendritic cells found in the gut mucosal immune system. CCL20 contributes to recruitment of CCR6-expressing cells to Peyer's patches and isolated lymphoid follicles in the intestine, thereby promoting the assembly and maintenance of organized lymphoid structures. Also, CCL20 expression is highly inducible in response to inflammatory signals. Thus, CCL20 is involved in both inflammatory and homeostatic functions in the immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341330 [Multi-domain]  Cd Length: 281  Bit Score: 85.58  E-value: 5.15e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  19 LLAIILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQgTWSFGLAGCRLCHYVCG 98
Cdd:cd15172    1 VFVPVIYSLICVVGLIGNSLVVITYAFYKRTKSMTDVYLLNMAIADILFVLTLPFWAVYEAH-QWIFGNFSCKLLRGIYA 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  99 VSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALR--VLAGIWVVSFLLATPVLVYRTVVALKTNMS-LCYPKYPSK 175
Cdd:cd15172   80 INFYSGMLLLACISVDRYIAIVQATKSFRLRSRTLAYSklICAAVWLLAILISLPTFIFSEVYDFGLEEQyVCEPKYPKN 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 176 EH----EAFHLIFEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILAFAAFWLPYHVVNLAEAARALAG 251
Cdd:cd15172  160 STaimwKLLVLSLQVSLGFFIPLLVMIFCYSFIIKTLLQAQNSQRHKAVRVVVAVVLVFLVCQVPYNIVLLIEAINLGEQ 239
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 966954328 252 QASGSglvGQRLKLARSVLIALAFLSSSVNPVLYACAG 289
Cdd:cd15172  240 QSCSS---EKAVAYAKTITECLAFFHCCLNPVLYAFIG 274
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
19-286 6.61e-19

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 85.63  E-value: 6.61e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  19 LLAIILLSVALAVGLPGNSFVVW--SILKRMKKRSVTALLVLNLALADLAVLLTAPFF-LHFLAQGTWSFGLAGCRLCHY 95
Cdd:cd14976    1 NLVSVVYMVVFTVGLLGNLLVLYllKSNKKLRQQSESNKFVFNLALTDLIFVLTLPFWaVEYALDFVWPFGTAMCKVVRY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  96 VCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALKTNMSLCYPKYPSK 175
Cdd:cd14976   81 VTKLNMYSSIFFLTALSVTRYIAVARALKHGWIRKAFGAFATTIAIWAAAALAAIPEAIFSTDTWSSVNHTLCLLRFPKN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 176 EHE--------AFHLIfEALTGFLLPFLAVVASYSDIGRRLQARRFRR---SRRTGRLVVLIILAFAAFWLPYHVVNLAE 244
Cdd:cd14976  161 SSVtrwynwlgMYQLQ-KVVLGFFLPLGIITLSYLLLLRFLQRKRGGSkrrKSRVTKSVFIVVLSFFICWLPNQALSLWS 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 966954328 245 A-ARALAGQASGSGLVGQRlkLARSVLIALAFLSSSVNPVLYA 286
Cdd:cd14976  240 AlIKFDDVPFSDAFFAFQT--YAFPVAICLAHSNSCLNPVLYC 280
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
25-289 7.34e-19

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 85.21  E-value: 7.34e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  25 LSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGtWSFGLAGCRLCHYVCGVSMYAS 104
Cdd:cd15177    7 YLVVFVLGLVGNGLVLATHTRYRRLRSMTDVYLLNLALADLLLLLTLPFAAAETLQG-WIFGNAMCKLIQGLYAINFYSG 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 105 VLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAG--IWVVSFLLATPVLVYRTVvALKTNMSLCYPKYPSKEHEAFH- 181
Cdd:cd15177   86 FLFLTCISVDRYVVIVRATSAHRLRPKTLFYSVLTSliVWLLSILFALPQLIYSRV-ENRSELSSCRMIFPEVVSRTVKg 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 182 --LIFEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILAFAAFWLPYHVVNLAEAARALAGQASgSGLV 259
Cdd:cd15177  165 atALTQVVLGFAIPLIVMAVCYAAIGRTLLAARGWERHRALRVIAALVVAFVLFQLPYSVVLLLDTADLLATLEL-SCSQ 243
                        250       260       270
                 ....*....|....*....|....*....|
gi 966954328 260 GQRLKLARSVLIALAFLSSSVNPVLYACAG 289
Cdd:cd15177  244 SKRKDIALLVTSGLAYVRCCLNPLLYAFVG 273
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
24-289 9.16e-19

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 84.72  E-value: 9.16e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  24 LLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGtWSFGLAGCRLCHYVCGVSMYA 103
Cdd:cd15182    6 FYYLVFLLSLLGNGLVLWILVKYEKLKTLTNIFILNLAISDLLFTFTLPFWASYHSSG-WIFGEILCKAVTSIFYIGFYS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 104 SVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALKTNMSLCYPKYPSKEHEAF--H 181
Cdd:cd15182   85 SILFLTLMTIDRYLAVVHPLSALRSRKLRYASLVSVAVWVISILASLPELILSTVMKSDEDGSLCEYSSIKWKLGYYyqQ 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 182 LIFealtgFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILAFAAFWLPYHVVNLaeaARALAGQASGSGLVGQ 261
Cdd:cd15182  165 NLF-----FLIPLGIIVYCYVRILQTLMRTRTMRKHRTVKLIFVIVLVFFLSWAPYNIVIF---LRSLKDLTIPICECSK 236
                        250       260
                 ....*....|....*....|....*...
gi 966954328 262 RLKLARSVLIALAFLSSSVNPVLYACAG 289
Cdd:cd15182  237 QLDYAFYICRNIAFSHCCLNPVFYVFVG 264
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
17-289 1.16e-18

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 84.63  E-value: 1.16e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  17 IVLLAIILLSValavglPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGtWSFGLAGCRLCHYV 96
Cdd:cd15178    5 VIYVLVFLLSL------PGNSLVVLVILYNRRSRSSTDVYLLHLAIADLLFALTLPFWAVSVVKG-WIFGTFMCKLVSLL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  97 CGVSMYASVLLITAMSLDRSLAVARPfvsqklrTKAMALR------VLAGIWVVSFLLATPVLVYRTVVALKTNMS-LCY 169
Cdd:cd15178   78 QEANFYSGILLLACISVDRYLAIVHA-------TRALTQKrhlvkfVCAGVWLLSLLLSLPALLNRDAFKPPNSGRtVCY 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 170 PKYPSKEHEAFHL---IFEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILAFAAFWLPYHVVNLAEAA 246
Cdd:cd15178  151 ENLGNESADKWRVvlrILRHTLGFLLPLVVMLFCYGFTIKTLLQTRSFQKHRAMRVIFAVVLAFLLCWLPYNVTVLIDTL 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 966954328 247 -RALAGQASGSglVGQRLKLARSVLIALAFLSSSVNPVLYACAG 289
Cdd:cd15178  231 mRTKLITETCE--LRNHVDVALYVTQILGFLHSCINPVLYAFIG 272
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
31-285 1.24e-18

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 84.52  E-value: 1.24e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  31 VGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITA 110
Cdd:cd15973   13 VGLIGNSMVIFVILRYAKMKTATNIYILNLAIADELFMLSVPFLAASAALQHWPFGSAMCRTVLSVDGINMFTSVFCLTV 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 111 MSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALKTNMSLCYPKYPSKEHEAFHLIFEALTGF 190
Cdd:cd15973   93 LSVDRYIAVVHPLRAARYRRPTVAKMINICVWILSLLVISPIIIFADTATRKGQAVACNLIWPHPAWSAAFVIYTFLLGF 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 191 LLPFLAVVASYSDIGRRLQARRFRR--------SRRTGRLVVLIILAFAAFWLPYHVVNLAEAaralagqasgsgLVGQR 262
Cdd:cd15973  173 LLPVLAIGLCYILIIGKMRAVALKAgwqqrrksEKKITRMVLMVVTVFVICWMPFYVVQLLNL------------FLPRL 240
                        250       260
                 ....*....|....*....|...
gi 966954328 263 LKLARSVLIALAFLSSSVNPVLY 285
Cdd:cd15973  241 DATVNHASLILSYANSCANPILY 263
7tmA_CXCR6 cd15173
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
24-289 1.74e-18

CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320301 [Multi-domain]  Cd Length: 270  Bit Score: 84.05  E-value: 1.74e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  24 LLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGtWSFGLAGCRLCHYVCGVSMYA 103
Cdd:cd15173    6 MYSVMFVTGLVGNSLVIVIYIFYEKLRTLTDIFLVNLAVADLLFLCTLPFWAYSAAHE-WIFGTVMCKITNGLYTINLYS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 104 SVLLITAMSLDRSLAVARPFVSQKLRTKAMALR--VLAGIWVVSFLLATPVLVYRTVVALKTnmSLCYPKYPSKEHEAFH 181
Cdd:cd15173   85 SMLILTCITVDRFIVIVQATKAHNCHAKKMRWGkvVCTLVWVISLLLSLPQFIYSEVRNLSS--KICSMVYPPDAIEVVV 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 182 LIFEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILAFAAFWLPYHVVNLAEAaralagqASGSGLVGQ 261
Cdd:cd15173  163 NIIQMTVGFFLPLLAMIICYSVIIKTLLHAKGFQKHKSLKIIFVVVAVFILTQLPYNIMKLIRT-------LHIENTDST 235
                        250       260
                 ....*....|....*....|....*...
gi 966954328 262 RLKLARSVLIALAFLSSSVNPVLYACAG 289
Cdd:cd15173  236 NFKYAILITEAIAYLHACLNPILYAFVG 263
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
85-285 2.07e-18

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 83.59  E-value: 2.07e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  85 FGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVAL-KT 163
Cdd:cd15206   68 FGEVMCKLIPYFQAVSVSVSTFTLVAISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSFLIMSPILVFSNLIPMsRP 147
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 164 NMSLCYPKYPSKEHEAFHLIFEALTGFLLPFLAVVASYSDIgrrLQARRFRRSRRTGRLVVLIILAFAAfWLPYHVVNLA 243
Cdd:cd15206  148 GGHKCREVWPNEIAEQAWYVFLDLMLLVIPGLVMSVAYGLI---SWTLLEAKKRVIRMLFVIVVEFFIC-WTPLYVINTW 223
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 966954328 244 EAARALAGQASGSGlvgqrlkLARSVLIALAFLSSSVNPVLY 285
Cdd:cd15206  224 KAFDPPSAARYVSS-------TTISLIQLLAYISSCVNPITY 258
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
23-295 2.52e-18

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 83.75  E-value: 2.52e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  23 ILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQ-GTWSFGLAGCRLCHYVCGVSM 101
Cdd:cd15194    5 ILYCLVFLVGAVGNAILMGALVFKRGVRRLIDIFISNLAASDFIFLVTLPLWVDKEVVlGPWRSGSFLCKGSSYIISVNM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 102 YASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRtVVALKTNMSLCYPKYPSKEHEAFH 181
Cdd:cd15194   85 YCSVFLLTCMSLDRYLAIVLPLVSRKFRTKHNAKVCCTCVWMLSCLLGLPTLLSR-ELKKYEEKEYCNEDAGTPSKVIFS 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 182 LIFEALTgFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRL------VVLIILAFAAFWLPYHVVNLAEAARALagQASG 255
Cdd:cd15194  164 LVSLIVA-FFLPLLSILTCYCTIIWKLCHHYQKSGKHQKKLrksikiVFIVVAAFVFSWMPFNLFKALAIASGL--QVEV 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 966954328 256 SGLVGQRLKLARSVLIALAFLSSSVNPVLYACAGGGLLRS 295
Cdd:cd15194  241 TCLPYTLAQLGMEVSAPLAFANSCANPFIYYFFDRYIRRA 280
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
19-286 6.42e-18

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 82.52  E-value: 6.42e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  19 LLAIILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCG 98
Cdd:cd15094    1 LISAVLYGLICIVGLVGNGLVIYVVLRYAKMKTVTNLYILNLAVADECFLIGLPFLIVTMILKYWPFGAAMCKIYMVLTS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  99 VSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALKTNMS--LCYPKYPSKE 176
Cdd:cd15094   81 INQFTSSFTLTVMSADRYLAVCHPIRSMRYRTPFIAKVVCATTWSISFLVMLPIILYASTVPDSGRYSctIVWPDSSAVN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 177 HEAFHLIFEALTGFLLPFLAVVASY-------SDIGRRLQARRFRRS-RRTGRLVVLIILAFAAFWLPYHVVNLAEAARA 248
Cdd:cd15094  161 GQKAFTLYTFLLGFAIPLLLISVFYtlvilrlRTVGPKNKSKEKRRShRKVTRLVLTVISVYIICWLPYWAFQVHLIFLP 240
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 966954328 249 LAGQASgsglvgqRLKLARSVLI-ALAFLSSSVNPVLYA 286
Cdd:cd15094  241 PGTDMP-------KWEILMFLLLtVLSYANSMVNPLLYA 272
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
24-294 9.11e-18

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 82.10  E-value: 9.11e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  24 LLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPF-FLHFLAQGTWSFGLAGCRLCHYVCGVSMY 102
Cdd:cd15158    6 LYSVITVFGLVGNGFALYVLIKTYRQKSAFHIYMLNLAVSDLLCVCTLPLrVVYYVHKGQWLFGDFLCRISSYALYVNLY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 103 ASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTvVALKTNMSLCY--PKYPSKEHEAF 180
Cdd:cd15158   86 CSIYFMTAMSFTRFLAIVFPVQNLNLVTVKKARIVCVGIWIFVTLTSSPFLMSGS-HDTETNKTKCFepPQSNQQLTKLL 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 181 HLIFEALT-GFLLPFLAVVASYSDI------GRRLQARRFRRSRRTGRLVVLIILAFAAFWLPYHV---VNLAEAARALA 250
Cdd:cd15158  165 VLNYISLVvGFIIPFLVILICYAMIirtllkNTMKARKQQSSRKKAIRMIIIVLLAFLVSFMPYHIqrtIHLHFLSRKDS 244
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 966954328 251 GQASgsglvgqRLKLARSVLI--ALAFLSSSVNPVLYACAGGGLLR 294
Cdd:cd15158  245 TCEE-------VLYMQKSVVItlCLAAANCCFDPLLYFFSGENFRR 283
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
22-289 1.16e-17

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 82.52  E-value: 1.16e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  22 IILLSVALAVGLPGNsFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVSM 101
Cdd:PHA03087  44 IVVYSTIFFFGLVGN-IIVIYVLTKTKIKTPMDIYLLNLAVSDLLFVMTLPFQIYYYILFQWSFGEFACKIVSGLYYIGF 122
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 102 YASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVAlKTNMSLCYPKYPSKEH--EA 179
Cdd:PHA03087 123 YNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYTTKK-DHETLICCMFYNNKTMnwKL 201
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 180 FHLIFEALTGFLLPFLAVVASYSDI-GRRLQARRFRRSRRTGRLVVLIILAFAAFWLPYHVVNLAEAARALAGQASGSGL 258
Cdd:PHA03087 202 FINFEINIIGMLIPLTILLYCYSKIlITLKGINKSKKNKKAIKLVLIIVILFVIFWLPFNVSVFVYSLHILHFKSGCKAV 281
                        250       260       270
                 ....*....|....*....|....*....|.
gi 966954328 259 VGQRLKLARSVLIALafLSSSVNPVLYACAG 289
Cdd:PHA03087 282 KYIQYALHVTEIISL--SHCCINPLIYAFVS 310
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
27-294 1.98e-17

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 81.50  E-value: 1.98e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  27 VALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGT-WSFGLAGCRLCHYVCGVSMYASV 105
Cdd:cd15377    9 LVFITGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTdWIFGDAMCKLQRFIFHVNLYGSI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 106 LLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALKTNMSLCYPKYPSKEHEAFHLIFE 185
Cdd:cd15377   89 LFLTCISVHRYTGVVHPLKSLGRLKKKNAICISVLVWLIVVVAISPILFYSGTGVRKNKTITCYDTTSDEYLRSYFIYSM 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 186 ALT--GFLLPFLAVVASYSDIGRRLQARRFRRSRRTGR--------LVVLIILAFAAFWLPYHVV-NLAEAARaLAGQAS 254
Cdd:cd15377  169 CTTvaMFCVPFILILGCYGLIVRALIYKDMKYTEENNAplrrksiyLVIIVLTVFAVSYLPFHVMkTLNLRAR-LDFQTP 247
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 966954328 255 GSGLVGQRLKLARSVLIALAFLSSSVNPVLYACAGGGLLR 294
Cdd:cd15377  248 AMCAFNDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRR 287
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
23-285 2.66e-17

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 80.59  E-value: 2.66e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  23 ILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQG-TWSFGLAGCRLCHYVCGVSM 101
Cdd:cd15365    5 FVYIFVIVISIPSNCISLYVSCLQIRKKNELGVYLFNLSLSDLLYIVILPLWIDYLWNGdNWTLSGFVCIFSAFLLYTNF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 102 YASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALKTNMSLCYPKYPSKEHEAFH 181
Cdd:cd15365   85 YTSTALLTCIALDRYLAVVHPLKFMHLRTIRTALSVSVAIWLLEICFNAVILTWEDSFHESSSHTLCYDKFPLEDWQARL 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 182 LIFEALTGFLLPFLAVVASYSDIGRRLQARRFRR---SRRTGRLVVLIILAFAAFWLPYHVVNLAEAARALAGQASgsgl 258
Cdd:cd15365  165 NLFRICLGYLLPLLIILFCYWKIYQAVRSNQATEdqeKKKIFKLLLLITVTFVICFTPYHVVLLIRSIVEPCDCRN---- 240
                        250       260
                 ....*....|....*....|....*..
gi 966954328 259 vGQRLKLARSVLIALAFLSSSVNPVLY 285
Cdd:cd15365  241 -AKWLYTLYKITVALTSLNCIADPFLY 266
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
31-285 2.93e-17

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 80.63  E-value: 2.93e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  31 VGLPGNSFVVWSILKRMKKR---SVTALLVLNLALADLAVLLTAPFFLH-FLAQGTWSFGLAGCRLCHYVCGVSMYASVL 106
Cdd:cd15338   13 LGIIGNSIVIYTIVKKSKFRcqqTVPDIFIFNLSIVDLLFLLGMPFLIHqLLGNGVWHFGETMCTLITALDTNSQITSTY 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 107 LITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALKTNMSLCYPKYPSKEHEAF-HLIFE 185
Cdd:cd15338   93 ILTVMTLDRYLATVHPIRSTKIRTPRVAVAVICLVWILSLLSITPVWMYAGLMPLPDGSVGCALLLPNPETDTYwFTLYQ 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 186 ALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRL--------VVLIILAFAAFWLPYHVVNLAEaaralagqasgsg 257
Cdd:cd15338  173 FFLAFALPLVVICVVYFKILQNMASTVAPLPQRSLRVrtkkvtrmAVAICLAFFICWAPFYILQLAH------------- 239
                        250       260       270
                 ....*....|....*....|....*....|..
gi 966954328 258 LVGQRLKLA----RSVLIALAFLSSSVNPVLY 285
Cdd:cd15338  240 LSIDRPSLAflyaYNVAISMGYANSCINPFLY 271
7tmA_GPR4 cd15366
proton-sensing G protein-coupled receptor 4, member of the class A family of ...
19-291 6.65e-17

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.


Pssm-ID: 320488 [Multi-domain]  Cd Length: 280  Bit Score: 79.84  E-value: 6.65e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  19 LLAIILLSVALAVGLPGNSFVVWSI-LKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVC 97
Cdd:cd15366    1 LFPPTLYIIVIVLGLPTNCLALWAAyLQVRQRNELGVYLLNLSVSDLLYIATLPLWIDYFLHRDNWIHGPESCKLFGFIF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  98 GVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALKTNMSLCYPKYPSKEH 177
Cdd:cd15366   81 YTNIYISIAFLCCISVDRYLAVAHPLRFAKVRRVKTAVAVSAVVWAIEIGANSAPLFHDELFRDRYNHTFCFEKYPMEDW 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 178 EAFHLIFEALTGFLLPFLAVVASYSDIGRRLQARRFR-------RSRRTGRLVVLIILAFAafwlPYHVVNLAEAARALA 250
Cdd:cd15366  161 VAWMNLYRVFVGFLFPWVLMLFSYRGILRAVRGNVSTeqqekakIKRLALSLIAIVLLCFA----PYHVLLLSRSVVYLG 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 966954328 251 GQASGSglVGQRLKLARSVLIALAFLSSSVNPVLYACAGGG 291
Cdd:cd15366  237 KPCDCG--FEERVFTAYHVSLALTSLNCVADPILYCLVNEG 275
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
31-289 8.24e-17

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 79.41  E-value: 8.24e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  31 VGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGtWSFGLAGCRLCHYVCGVSMYASVLLITA 110
Cdd:cd15174   13 VGAVGNSLVVLIYTYYRRRKTMTDVYLLNLAIADLLFLCTLPFWATAASSG-WVFGTFLCKVVNSMYKINFYSCMLLLTC 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 111 MSLDRSLAVARPFVSQKLRTKAMALR--VLAGIWVVSFLLATPVLVYRTVVALKTNMSlCYPKYPSKEHEAFHLIFEALT 188
Cdd:cd15174   92 ISVDRYIAIVQATKAHNSKNKRLLYSklVCFFVWLLSTILSLPEILFSQSKEEESVTT-CTMVYPSNESNRFKVAVLALK 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 189 ---GFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILAFAAFWLPYHVVNLAEAARALAGQASgSGLVGQRLKL 265
Cdd:cd15174  171 vtvGFFLPFVVMVICYTLIIHTLLQAKRFQKHKALKVIIAVVTVFVLSQLPYNSILLIKTINAYNITIT-DCATSQNLDI 249
                        250       260
                 ....*....|....*....|....
gi 966954328 266 ARSVLIALAFLSSSVNPVLYACAG 289
Cdd:cd15174  250 AGQVTQSIAFLHSCLNPFLYVFVG 273
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
24-289 1.01e-16

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 79.14  E-value: 1.01e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  24 LLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYA 103
Cdd:cd15183    6 LYSLVFIIGVVGNVLVVLVLIQHKRLRNMTSIYLFNLAISDLVFLFTLPFWIDYKLKDDWIFGDAMCKFLSGFYYLGLYS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 104 SVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLvYRTVVALKTNMSLCYPKYPSKEHEAFhLI 183
Cdd:cd15183   86 EIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWALAILASMPCL-YFFKSQWEFTHHTCSAHFPRKSLIRW-KR 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 184 FEALT----GFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILAFAAFWLPYHVVNLAEAARALAgqASGSGLV 259
Cdd:cd15183  164 FQALKlnllGLILPLLVMIICYTGIINILLRRPNEKKAKAVRLIFVITLLFFLLWTPYNLAAFVSAFQDVL--FTPSCEQ 241
                        250       260       270
                 ....*....|....*....|....*....|
gi 966954328 260 GQRLKLARSVLIALAFLSSSVNPVLYACAG 289
Cdd:cd15183  242 SQQLDLALQVTEVIAYTHCCVNPVIYVFVG 271
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
24-287 1.15e-16

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 79.02  E-value: 1.15e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  24 LLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYA 103
Cdd:cd14999    5 VLSLMCVVGVAGNVYTLVVMCLSMRPRASMYVYILNLALADLLYLLTIPFYVSTYFLKKWYFGDVGCRLLFSLDFLTMHA 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 104 SVLLITAMSLDRSLAVARPFVSQKlRTKAMAlRVLAG-IWVVSFLLATPVLVY---RTVVALKTNMSLCYPKYPSKEHEA 179
Cdd:cd14999   85 SIFTLTVMSTERYLAVVKPLDTVK-RSKSYR-KLLAGvIWLLSLLLTLPMAIMirlVTVEDKSGGSKRICLPTWSEESYK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 180 FHLIFEALTGFLLPFLAVVASY---------SDIGRRLQARRFRRSRRTGRLVVLIILAFAAFWLPYHVVNLAEAARALA 250
Cdd:cd14999  163 VYLTLLFSTSIVIPGLVIGYLYirlarkywlSQAAASNSSRKRLPKQKVLKMIFTIVLVFWACFLPFWIWQLLYLYSPSL 242
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 966954328 251 GQASGSGLVGQRLklarsvLIALAFLSSSVNPVLYAC 287
Cdd:cd14999  243 SLSPRTTTYVNYL------LTCLTYSNSCINPFLYTL 273
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
23-290 1.38e-16

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 78.58  E-value: 1.38e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  23 ILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGtWSFGLAGCRLCHYVCGVSMY 102
Cdd:cd15180    5 VLYSLVFLLGLLGNGLVLAVLLQKRRNLSVTDTFILHLALADILLLVTLPFWAVQAVHG-WIFGTGLCKLAGAVFKINFY 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 103 ASVLLITAMSLDRSLAV--ARPFVSQKlRTKAMALRVLAgIWVVSFLLATPVLVYRTVVA-LKTNMSLCYPKYPSKEHEA 179
Cdd:cd15180   84 CGIFLLACISFDRYLSIvhAVQMYSRK-KPMLVHLSCLI-VWLFCLLLSIPDFIFLEATKdPRQNKTECVHNFPQSDTYW 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 180 FHL--IFEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVL-IILAFAAFWLPYHVVNLAEAARALAGQASGS 256
Cdd:cd15180  162 WLAlrLLYHIVGFLLPLAVMVYCYTSILLRLLRSSQGFQKQRAIRVIVaVVVVFFLCWTPYNIALLVDTLIDLSVLDRNC 241
                        250       260       270
                 ....*....|....*....|....*....|....
gi 966954328 257 GLVGqRLKLARSVLIALAFLSSSVNPVLYACAGG 290
Cdd:cd15180  242 GTES-RLDIALSVTSSLGYFHCCLNPLLYAFVGV 274
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
72-285 1.44e-16

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 78.70  E-value: 1.44e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  72 PFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATP 151
Cdd:cd15979   55 PFTLIPNLMGTFIFGEVICKAVAYLMGVSVSVSTFSLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGLIMIP 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 152 VLVYRTVVAL----KTNMSLCYPKYPSKEHEAFHLIFEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLII 227
Cdd:cd15979  135 YPVYSVTVPVpvgdRPRGHQCRHAWPSAQVRQAWYVLLLLILFFIPGVVMIVAYGLISRELYRGLLAKKRVIRMLVVIVA 214
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 966954328 228 LAFAAfWLPYHVVNlaeAARALAGQASGSGLVGQRLklarSVLIALAFLSSSVNPVLY 285
Cdd:cd15979  215 MFFLC-WLPIFSAN---TWRAFDPLSAHRALSGAPI----SFIHLLSYTSACVNPLVY 264
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
23-289 2.42e-16

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 78.27  E-value: 2.42e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  23 ILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQG-TWSFGLAGCRLCHYVCGVSM 101
Cdd:cd15381    5 IYLWIIFVLGTIENAFVLIVFCLHKSSCTVAEIYLGNLAAADLLLVCCLPFWAINISNGfNWPFGEFLCKSVNAVIYMNL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 102 YASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALKT-NMSLCYPKYPSKEHEAF 180
Cdd:cd15381   85 YSSIYFLMMVSIDRYLALVKTMSSGRMRRPACAKLNCLIIWMFGLLMSTPMIVFRTVMYFPEyNITACVLDYPSEGWHVA 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 181 HLIFEALTGFLLPFLAVVASYSDI------GRRLQARRFRRSRRTGRLVVLIILAFAAFWLPYHVVNLAEAARALAGQAS 254
Cdd:cd15381  165 LNILLNVVGFLIPLSIITFCSTQIiqvlrnNKMQKFKEIQTERKATVLVLAVLLMFFICWLPFHIFTFLDTLHKLGLISG 244
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 966954328 255 GSglVGQRLKLARSVLIALAFLSSSVNPVLYACAG 289
Cdd:cd15381  245 CR--WEDILDIGTQIATFLAYSNSCLNPLLYVIVG 277
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
23-290 3.16e-16

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 77.93  E-value: 3.16e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  23 ILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFL-HFLAQGTWSFGLAGCRLCHYVCGVSM 101
Cdd:cd15921    5 TAYILIFILGLTGNSISVYVFLSQYRSQTPVSVLMVNLAISDLLLVCTLPLRLtYYVLNSHWPFGDIACRIILYVLYVNM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 102 YASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALKTNMS-LCYPKYPSKEHEAF 180
Cdd:cd15921   85 YSSIYFLTALSVFRYLALVWPYLYLRVQTHSVAGIICGLIWILMGLASSPLLFAKSKQHDEGSTRcLELAHDAVDKLLLI 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 181 HLIfEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRR------TGRLVVLIILAFAAFWLPYHVVNLAEAarALAGQAS 254
Cdd:cd15921  165 NYV-TLPVGFVVPFMTVIFCYIFIIKNLLKPSPALGRTrpsrrkACALIIISLGIFLVCFLPYHIVRTIHL--ITERQIK 241
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 966954328 255 GSGLVGQRLKLARSVLIALAFLSSSVNPVLYACAGG 290
Cdd:cd15921  242 ESCGYILRVRKAAVITLCLAASNSCFDPLLYFFVGE 277
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
24-286 5.08e-16

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 77.30  E-value: 5.08e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  24 LLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYA 103
Cdd:cd15089    6 LYSVVCVVGLLGNVLVMYGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 104 SVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALKTNMSLCYPKYPSKE--HEAFH 181
Cdd:cd15089   86 SIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLSSGVGVPIMVMAVTKTPRDGAVVCMLQFPSPSwyWDTVT 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 182 LIFEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRR--------TGRLVVLIILAFAAFWLPYHVVNLAeaaRALAGQA 253
Cdd:cd15089  166 KICVFIFAFVVPILVITVCYGLMILRLRSVRLLSGSKekdrnlrrITRMVLVVVAAFIICWTPIHIFVIV---WTLVDID 242
                        250       260       270
                 ....*....|....*....|....*....|...
gi 966954328 254 SGSGLVGQRLKLArsvlIALAFLSSSVNPVLYA 286
Cdd:cd15089  243 RRNPLVVAALHLC----IALGYANSSLNPVLYA 271
7tmA_CCR7 cd15175
CC chemokine receptor type 7, member of the class A family of seven-transmembrane G ...
82-289 6.55e-16

CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR7 is a major homeostatic receptor responsible for lymph node development and effective adaptive immune responses and plays a critical role in trafficking of dendritic cells and B and T lymphocytes. Its only two ligands, CCL and CCl21, are primarily produced by stromal cells in the T cell zones of lymph nodes and spleen. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341331 [Multi-domain]  Cd Length: 278  Bit Score: 76.73  E-value: 6.55e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  82 TWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVL--AGIWVVSFLLATPVLVYrTVV 159
Cdd:cd15175   63 KWVFGEEMCKAVYCLYKMSFFSGMLLLMCISIDRYFAIVQAASAHRHRSRAVFISKVssLGVWVLAFILSIPELLY-SGV 141
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 160 ALKTNMSLCYPKYPSK-EHEAFHLIFEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILAFAAFWLPYH 238
Cdd:cd15175  142 NNNDGNGTCSIFTNNKqTLSVKIQISQMVLGFLVPLVVMSFCYSVIIKTLLQARNFEKNKAIKVIIAVVVVFVVFQLPYN 221
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 966954328 239 VVNLAEAARALAGQASgSGLVGQRLKLARSVLIALAFLSSSVNPVLYACAG 289
Cdd:cd15175  222 SVMLVSTLSSFKGNTT-DCDYSKNLDFALDVTYSLACFRCCLNPFLYAFIG 271
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
23-242 7.15e-16

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 76.92  E-value: 7.15e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  23 ILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALA-DLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVSM 101
Cdd:cd15927    5 ILFALIFLVGVLGNGTLILIFLRNKSMRNVPNIFILSLALGdLLLLLTCVPFTSTIYTLDSWPFGEFLCKLSEFLKDTSI 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 102 YASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALKT----NMSLCYPkYPS--- 174
Cdd:cd15927   85 GVSVFTLTALSADRYFAIVNPMRKHRSQATRRTLVTAASIWIVSILLAIPEAIFSHVVTFTLtdnqTIQICYP-YPQelg 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 175 KEHEAFHLIFEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGR--------------LVVLIILAFAAFWLPYHVV 240
Cdd:cd15927  164 PNYPKIMVLLRFLVYYLIPLLIIGVFYVLMARHLIRSTRNIGSGQNQaaqrqiearkkvakTVLAFVVLFAVCWLPRHVF 243

                 ..
gi 966954328 241 NL 242
Cdd:cd15927  244 ML 245
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
23-286 8.16e-16

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 76.66  E-value: 8.16e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  23 ILLSVALAVGLPGNSFVVWSILKRMKK--RSVTALLVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVS 100
Cdd:cd15376    5 PILGVEFLVAVLGNGLALWLFVTRERRpwHTGVVFSFNLAVSDLLYALSLPLLAAYYYPPKNWRFGEAACKLERFLFTCN 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 101 MYASVLLITAMSLDRSLAVARPFVSQ-KLRTKaMALRVLAGIWVVSFLLATPVLVYRTVVALKTNMSLCYPKYPSKEHEA 179
Cdd:cd15376   85 LYGSIFFITCISLNRYLGIVHPFFTRsHVRPK-HAKLVSLAVWLLVAALSAPVLSFSHLEVERHNKTECLGTAVDSRLPT 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 180 F--HLIFEALTGFLLPFLAVVASYSDIGRRLQARRFRRSR---RTGRLVVLIILAFAAFWLPYHV---VNLAEAARALAG 251
Cdd:cd15376  164 YlpYSLFLAVVGCGLPFLLTLASYLAIVWAVLRSPGITTLekrKVAALVAVVVALYAVSFVPYHIlrnLNLYRRLQWLKA 243
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 966954328 252 QASGsglvgqRLKLARSVLIALAFLSSSVNPVLYA 286
Cdd:cd15376  244 AASL------RIYFAYQVTKGLVTLNMCIHPLLYM 272
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
23-286 8.18e-16

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 76.68  E-value: 8.18e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  23 ILLSVALAVGLPGNSFVV---WSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGV 99
Cdd:cd15002    4 ILLGVICLLGFAGNLMVIgilLNNARKGKPSLIDSLILNLSAADLLLLLFSVPFRAAAYSKGSWPLGWFVCKTADWFGHA 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 100 SMYASVLLITAMSLDRSLAVARPF--VSQKLRTkamALRVLAGIWVVSFLLATPVLVYRTVV--ALKTNMSLCYPkYPSK 175
Cdd:cd15002   84 CMAAKSFTIAVLAKACYMYVVNPTkqVTIKQRR---ITAVVASIWVPACLLPLPQWLFRTVKqsEGVYLCILCIP-PLAH 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 176 EHEAFHLIFEALTGFLLPFLAVVASYSDI-------GRRLQARRFRRSRRTGRLVVLII-LAFAAFWLPYHVVNLAEaar 247
Cdd:cd15002  160 EFMSAFVKLYPLFVFCLPLTFALFYFWRAygqcqrrGTKTQNLRNQIRSRKLTHMLLSVvLAFTILWLPEWVAWLWL--- 236
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 966954328 248 aLAGQASGSGLVGQRLKLARsvliALAFLSSSVNPVLYA 286
Cdd:cd15002  237 -IHIKSSGSSPPQLFNVLAQ----LLAFSISSVNPIIFL 270
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
31-245 1.12e-15

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 76.33  E-value: 1.12e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  31 VGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQ-GTWSFGLAGCRLCHYVCGVSMYASVLLIT 109
Cdd:cd14987   13 IGLLANSVVVWVNLQAKRTGYETHLYILNLAIADLCVVATLPVWVVSLVQhNQWPMGEFTCKITHLIFSINLFGSIFFLT 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 110 AMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVY-RTVVALKTNMSLCYPKYPSKEHEAFHLIFEALT 188
Cdd:cd14987   93 CMSVDRYLSVTLFGNTSSRRKKIVRRIICVLVWLLAFVASLPDTYFlKTVTSPSNNETYCRSFYPEESFKEWLIGMELVS 172
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 189 ---GFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILAFAAFWLPYHVVNLAEA 245
Cdd:cd14987  173 ivlGFVIPFPIIAVFYFLLARAISASSDQERKSSRKIIFSYVVVFLVCWLPYHTVVLLDI 232
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
24-289 1.42e-15

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 76.02  E-value: 1.42e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  24 LLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYA 103
Cdd:cd15185    6 LYSLVFIVGLLGNVVVVVILIKYRRLRIMTNIYLLNLAISDLLFLFTLPFWIHYVRWNNWVFGHGMCKLLSGFYYLGLYS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 104 SVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALkTNMSLCYPKYPSKEHEA---F 180
Cdd:cd15185   86 EIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWGLAVLAALPEFIFYETQEL-FEEFLCSPLYPEDTEDSwkrF 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 181 HLIFEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILAFAAFWLPYHVVNLAEAARALAGQASGSGlvG 260
Cdd:cd15185  165 HALRMNIFGLALPLLIMVICYTGIIKTLLRCPSKKKYKAIRLIFVIMVVFFIFWTPYNLVLLLSAFQSIFFETDCER--S 242
                        250       260
                 ....*....|....*....|....*....
gi 966954328 261 QRLKLARSVLIALAFLSSSVNPVLYACAG 289
Cdd:cd15185  243 KHLDLAMQVTEVIAYTHCCINPVIYAFVG 271
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
18-201 2.98e-15

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 74.79  E-value: 2.98e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  18 VLLAIILLSVALaVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGT-WSFGLAGCRLCHYV 96
Cdd:cd15162    1 VFLPAVYTLVFV-VGLPANGMALWVLLFRTKKKAPAVIYMANLAIADLLLVIWLPFKIAYHIHGNnWIFGEALCRLVTVA 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  97 CGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALK-TNMSLCYPKYPSK 175
Cdd:cd15162   80 FYGNMYCSILLLTCISIDRYLAIVHPMGHRRLRARRYALGTCLAIWLLALLVTLPLYLVKQTIFLPaLDITTCHDVLPEQ 159
                        170       180
                 ....*....|....*....|....*....
gi 966954328 176 EHEAFHLIF---EALTGFLLPFLAVVASY 201
Cdd:cd15162  160 LLVGDWFYYflsLAIVGFLIPFILTASCY 188
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
23-285 3.09e-15

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 74.83  E-value: 3.09e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  23 ILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQG-TWSFGLAGCRLCHYVCGVSM 101
Cdd:cd15928    5 AVCSVLMLVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDLLIFLVLPLDLYRLWRYrPWRFGDLLCRLMYFFSETCT 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 102 YASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALKTNMSL----CYPKYPSKEH 177
Cdd:cd15928   85 YASILHITALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIVSAGPALVLVGVEHIQGQQTPrgfeCTVVNVSSGL 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 178 EAFHLIFEALTgFLLPFLAVVASYSDIGRRLQARRFRRSRRTGR-----------LVVLIILAFAAFWLPYHVvnlaeaA 246
Cdd:cd15928  165 LSVMLWVSTSF-FFVPMVCLSLLYGLIGRALWDRRQRSRTAGASrrdnnhrqtvrMLAVIVLAFVLCWLPFHV------G 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 966954328 247 RALAGQASGSGL----VGQRLKLARSVLIalaFLSSSVNPVLY 285
Cdd:cd15928  238 RVIFNHSRASTKhlhyVSQYFNLVSFVLF---YLSAAINPILY 277
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
23-285 4.62e-15

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 74.45  E-value: 4.62e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  23 ILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGT-WSFGLAGCRLCHYVCGVSM 101
Cdd:cd15132    5 IVCLILFVVGVTGNTMTVLIIRRYKDMRTTTNLYLSSMAVSDLLILLCLPFDLYRLWKSRpWIFGEFLCRLYHYISEGCT 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 102 YASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLV-----YRTVVALKTNMSLCYPKYPSKE 176
Cdd:cd15132   85 YATILHITALSIERYLAICFPLRAKVLVTRRRVKCVIAALWAFALLSAGPFLFlvgveQDNNIHPDDFSRECKHTPYAVS 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 177 HEAFHLIFEALTG-FLLPFLAVVASYSDIGRRL-----------QARRFRRSRRTGRLVVLIILAFAAFWLPYHVvnlae 244
Cdd:cd15132  165 SGLLGIMIWVTTTyFFLPMLCLSFLYGFIGRKLwkskndlrgpnAAARERSHRQTVRILAVVVLAFIICWLPFHI----- 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 966954328 245 aARALAGQASGSG--LVGQRLKLarsVLIALAFLSSSVNPVLY 285
Cdd:cd15132  240 -GRILFANTEDYRtmMFSQYFNI---VAMQLFYLSASINPILY 278
7tmA_SUCNR1_GPR91 cd15378
succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
23-290 5.47e-15

succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Succinate receptor (SUCNR1) GPR91 exclusively couples to G(i) protein to inhibit cAMP production and also activates PLC-beta to increase intracellular calcium concentrations in an inositol phosphate dependent mechanism. Succinate, an intermediate molecule of the citric cycle, is shown to cause cardiac hypertrophy via GPR91 activation. Furthermore, succinate-induced GPR91 activation is involved in the regulation of renin-angiotensin system and is suggested to play an important role in the development of renovascular hypertension and diabetic nephropathy. SUCNR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC).


Pssm-ID: 320500 [Multi-domain]  Cd Length: 283  Bit Score: 74.37  E-value: 5.47e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  23 ILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVSMY 102
Cdd:cd15378    5 TMYSIEFVLGFIGNTIVILGYIFCLKNWKSSNIYLFNLSVSDLAFLCTLPMLVYSYSNGQWLFGDFLCKSNRYLLHANLY 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 103 ASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYrTVVALKTNMSLCYpKYPSKEHEAFHL 182
Cdd:cd15378   85 SSILFLTFISIDRYLLIKYPFREHILQKKRSAVAISLAIWVLVTLELLPILTF-IGPNLKDNVTKCK-DYASSGDATNSL 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 183 IFE---ALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTG-----RLVVLIILAFAAFWLPYHVV-NLAEAARALAGQA 253
Cdd:cd15378  163 IYSlflTVTGFLIPLCVMCFFYYKIALFLKNRNRQLANATSfekplTLVILAVVIFSVLFTPYHVMrNVRIASRLDSIGV 242
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 966954328 254 SGSGLVGqrLKLARSVLIALAFLSSSVNPVLYACAGG 290
Cdd:cd15378  243 SECTLII--IKSLYIVTRPIAFLNSVINPVFYFLMGD 277
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
23-242 7.19e-15

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 73.65  E-value: 7.19e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  23 ILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFF-LHFLAQGTWSFGLAGCRLCHYVCGVSM 101
Cdd:cd14988    5 ILYLVIFVVGLVENVLVIWVNWHRWGSKNLVNLYILNMAIADLGVVLTLPVWmLEVMLDYTWLWGSFLCKFTHYFYFANM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 102 YASVLLITAMSLDRSLAVARPFVSQKlRTKAMALRVL-AGIWVVSFLLATPVLVYRTVVALKTNMslCYPKYPSKEHEAF 180
Cdd:cd14988   85 YSSIFFLTCLSVDRYLTLTSSSPFWQ-QHQHRIRRALcAGIWVLSAIIPLPEVVHMQLLDGVEPM--CLFLAPFETYDEW 161
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966954328 181 HLIFEALT---GFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILAFAAFWLPYHVVNL 242
Cdd:cd14988  162 ALAVSLLTliiGFLIPFSIIAVFNVLTARYIRTAGRPESRRHCLLIYAYILVFVVCWLPYHVTLL 226
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
22-285 7.47e-15

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 73.75  E-value: 7.47e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  22 IILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALA-DLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVS 100
Cdd:cd15978    4 ILLYSLIFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSdLMLCLFCMPFTLIPNLLKDFIFGSAVCKTATYFMGIS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 101 MYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVAL----KTNMSLCYPKYPSKE 176
Cdd:cd15978   84 VSVSTFNLVAISLERYSAICKPLKSRVWQTKSHALKVIAATWCLSFTIMLPYPIYSNLVPFtrinNSTGNMCRLLWPNDV 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 177 HEAFHLIFEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILAFAAF--WLPYHVVNlaeAARALAGQAS 254
Cdd:cd15978  164 TQQSWYIFLLLILFLIPGIVMMTAYGLISLELYRGIKFLMAKKRVIRMLIVIVILFFlcWTPIFSAN---AWRAFDTRSA 240
                        250       260       270
                 ....*....|....*....|....*....|.
gi 966954328 255 GSGLVGQRLklarSVLIALAFLSSSVNPVLY 285
Cdd:cd15978  241 DRLLSGAPI----SFIHLLSYTSACVNPIIY 267
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
20-242 8.08e-15

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 73.69  E-value: 8.08e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  20 LAIILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALA-DLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCG 98
Cdd:cd15202    2 LLIVAYSFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVAdIMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  99 VSMYASVLLITAMSLDRSLAVARPFvsQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTV----VALKTNMSLCYPKYPS 174
Cdd:cd15202   82 CSVHVSAYTLTAIAVDRYQAIMHPL--KPRISKTKAKFIIAVIWTLALAFALPHAICSKLetfkYSEDIVRSLCLEDWPE 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 175 KEHEA---FHLIFEALTgFLLPFLAVVASYSDIGRRLQA-------------RRFRRSRRTGRLVVLIILAFAAFWLPYH 238
Cdd:cd15202  160 RADLFwkyYDLALFILQ-YFLPLLVISFAYARVGIKLWAsnmpgdatteryfALRRKKKKVIKMLMVVVVLFALCWLPFN 238

                 ....
gi 966954328 239 VVNL 242
Cdd:cd15202  239 IYVL 242
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
80-289 1.06e-14

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 73.29  E-value: 1.06e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  80 QGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVV 159
Cdd:cd15380   63 QFNWPFGNFLCRVISGVIKANLFISIFLVVAISQDRYRTLVHTMTSRRQRSRRQAQVICLLIWVFGGLLSIPTFLFRSVK 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 160 AL-KTNMSLCYPKYPskeHEAFH---LIFEALTGFLLPFLAVVASYSDI--------GRRLQARRFRRSRRTGRLVVLII 227
Cdd:cd15380  143 HVpDLNISACILLFP---HEAWHfarRVELNIVGFLLPLAAIVFFNFHIiaslrertEESRKRCGGLKDTKATRLILTLV 219
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966954328 228 LAFAAFWLPYHVVNLAEAARALagQASGSGLVGQRLKLARSVLIALAFLSSSVNPVLYACAG 289
Cdd:cd15380  220 LMFLVCWTPYHFFAFLDFLFQV--EVIQGCFWEEFIDLGLQLANFFAFANSCLNPVIYVFAG 279
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
83-287 2.58e-14

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 72.27  E-value: 2.58e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  83 WSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFvSQKLrTKAMALRVLAGIWVVSFLLATPVLVYRTVVALK 162
Cdd:cd15207   66 WPFGDVMCKLSPLVQGVSVAASVFTLVAIAVDRYRAVVHPT-EPKL-TNRQAFVIIVAIWVLALAIMIPQALVLEVKEYQ 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 163 TN----MSLCYPKYPSKEHEAFHLIFEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGR----------------L 222
Cdd:cd15207  144 FFrgqtVHICVEFWPSDEYRKAYTTSLFVLCYVAPLLIIAVLYVRIGYRLWFKPVPGGGSASReaqaavskkkvrvikmL 223
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966954328 223 VVLIILaFAAFWLPYHVVNLAEAARALagqasgsGLVGQRLKLARSVLIA--LAFLSSSVNPVLYAC 287
Cdd:cd15207  224 IVVVVL-FALSWLPLHTVTMLDDFGNL-------SPNQREVLYVYIYPIAhwLAYFNSCVNPIVYGY 282
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
26-286 2.65e-14

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 72.29  E-value: 2.65e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  26 SVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYASV 105
Cdd:cd15091    8 SVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSI 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 106 LLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVY-RTVVALKTNMSLCYPKYPSKEHEAFHLIF 184
Cdd:cd15091   88 FTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLgGTKVREDVDSTECSLQFPDDDYSWWDTFM 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 185 EA---LTGFLLPFLAVVASYSDIGRRLQARRFRRSR--------RTGRLVVLIILAFAAFWLPYHVVNLAEaarALAGQA 253
Cdd:cd15091  168 KIcvfIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSrekdrnlrRITRLVLVVVAVFVVCWTPIHIFILVE---ALGSVS 244
                        250       260       270
                 ....*....|....*....|....*....|...
gi 966954328 254 SGSGLVGqrlklARSVLIALAFLSSSVNPVLYA 286
Cdd:cd15091  245 HSTAAVS-----SYYFCIALGYTNSSLNPILYA 272
7tmA_GPR55-like cd15165
G protein-coupled receptor 55 and similar proteins, member of the class A family of ...
29-198 4.78e-14

G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR55 shares closest homology with GPR35, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Lysophosphatidylinositol (LPI) is currently considered as the endogenous ligand for GPR55, although the receptor was initially de-orphanized as a cannabinoid receptor and binds many cannabinoid ligands.


Pssm-ID: 320293 [Multi-domain]  Cd Length: 277  Bit Score: 71.21  E-value: 4.78e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  29 LAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFlAQGTWSFGLAGCRLCHYVCGVSMYASVLLI 108
Cdd:cd15165   11 FVLGLLLNLMALWVFLFKIKKWTESTIYMINLALNDLLLLLSLPFKMHS-SKKQWPLGRTLCSFLESLYFVNMYGSILII 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 109 TAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVvalKTNMSLCYPKYPSKEHEAFHLIFEALT 188
Cdd:cd15165   90 VCISVDRYIAIRHPFLAKRLRSPRKAAIVCLTIWVFVWAGSIPIYSFHDK---PTNNTRCFHGFSNKTWSKKVIVVVEEF 166
                        170
                 ....*....|
gi 966954328 189 GFLLPFLAVV 198
Cdd:cd15165  167 GFLIPMAVMV 176
7tmA_GPR68_OGR1 cd15367
G protein-coupled receptor 68, member of the class A family of seven-transmembrane G ...
29-239 5.06e-14

G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors; The ovarian cancer G-protein receptor 1 (OGR1, also known as GPR68) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), and the G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Knock-out mice studies have suggested that OGR1 plays a role in the regulation of insulin secretion and glucose metabolism. OGR1 couples to G(q/11) proteins and activates phospholipase C and Ca2+ signaling pathways.


Pssm-ID: 320489 [Multi-domain]  Cd Length: 276  Bit Score: 71.33  E-value: 5.06e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  29 LAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQG-TWSFGLAGCRLCHYVCGVSMYASVLL 107
Cdd:cd15367   11 LVVGLPANCLSLYYGYLQIKAKNELGIYLCNLTVADLLYIFSLPFWLQYVLQHdNWTYSELLCKICGILLYENIYISIGF 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 108 ITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALKTNMSLCYPKYPSKEHEAFHLIFEAL 187
Cdd:cd15367   91 LCCISVDRYLAVVHPFRFHAFRTMKAATLVSTVIWLKELMTCVFFFLHGEISKDKENHSVCFEHYPIKAWEHNINYYRFY 170
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 966954328 188 TGFLLPFLAVVASYSDIGRRLQARRFRRSRRTG---RLVVLIILAFAAFWLPYHV 239
Cdd:cd15367  171 AGFLFPIFLLSFSYCRILRAVRKSHGTQKSQKIqikRLVLSTVVIFLVCFGPYHI 225
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
31-285 5.12e-14

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 71.28  E-value: 5.12e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  31 VGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFL-HFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLIT 109
Cdd:cd15161   13 LAFPGNTLALWLFIHDRKSGTPSNVFLMHLAVADLSYVLILPMRLvYHLSGNHWPFGEVPCRLAGFLFYLNMYASLYFLA 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 110 AMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALkTNMSLCYPKYpsKEHEAFHLIFEALTG 189
Cdd:cd15161   93 CISVDRFLAIVHPVKSMKIRKPLYAHVVCGFLWVIVTVAMAPLLVSPQTVEV-NNTTVCLQLY--REKASRGALVSLAVA 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 190 FLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILAFAAF---WLPYHVVNLAEAARALAGQASGSGLvgQRLKLA 266
Cdd:cd15161  170 FTIPFVTTVTCYLLIIRSLRTGKREEKPLKDKAIKMIILVLTIFlicFVPYHISRYIYILSHNGAGASCSSR--RGLALA 247
                        250
                 ....*....|....*....
gi 966954328 267 RSVLIALAFLSSSVNPVLY 285
Cdd:cd15161  248 NRITSCLTCLNGALDPVMY 266
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
19-285 5.81e-14

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 71.35  E-value: 5.81e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  19 LLAIILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGT-WSFGLAGCRLCHYVC 97
Cdd:cd15968    1 ILLPICYSFVFLLGLPLNSVVLTRCCRHTKAWTRTAIYMVNLALADLLYALSLPLLIYNYAMRDrWLFGDFMCRLVRFLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  98 GVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVY-RTvvALKTNMSLCYPKYPSKE 176
Cdd:cd15968   81 YFNLYGSILFLTCISVHRYLGICHPMRPWHKETRRAAWLTCVLVWILVFAQTLPILIFaRT--GIIRNRTVCYDLAPPAL 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 177 HEAFHL--IFEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGR-------LVVLIILAFAAFWLPYHVVNLAEAAR 247
Cdd:cd15968  159 FPHYVPygMALTVSGFLLPFSIILWCYCLVVRTLCRTLGPAEPPAQArrrksirTIVTVTLLFALCFLPFHITRTIYLAV 238
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 966954328 248 ALAGQASGSGLvgQRLKLARSVLIALAFLSSSVNPVLY 285
Cdd:cd15968  239 RVTPGVPCHVL--EAVAACYKITRPLASANSVLNPLLY 274
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
20-242 7.42e-14

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 70.92  E-value: 7.42e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  20 LAIILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALA-DLAVLLTAPFFLHF-LAQGTWSFGLAGCRLCHYVC 97
Cdd:cd15394    2 LIIPLYSLVVLVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSdMLMCATCVPLTLAYaFEPRGWVFGRFMCYFVFLMQ 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  98 GVSMYASVLLITAMSLDRSLAVARPFvSQKLRTKAMALrVLAGIWVVSFLLATPVLVYRTVVALKT-NMSLCYPKYPSKE 176
Cdd:cd15394   82 PVTVYVSVFTLTAIAVDRYYVTVYPL-RRRISRRTCAY-IVAAIWLLSCGLALPAAAHTYYVEFKGlDFSICEEFWFGQE 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 177 HE--AFHLIFEALTgFLLPFLAVVASYSDIGRRLQARRFRRSRRTGR-------------LVVLIILAFAAFWLPYHVVN 241
Cdd:cd15394  160 KQrlAYACSTLLIT-YVLPLLAISLSYLRISVKLRNRVVPGSMTQSQaewdrarrrktfrLLVVVVVAFAICWLPLHIFN 238

                 .
gi 966954328 242 L 242
Cdd:cd15394  239 V 239
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
22-285 1.20e-13

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 70.48  E-value: 1.20e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  22 IILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLltapFF-----LHFLAQGTWSFGLAGCRLCHYV 96
Cdd:cd14986    4 VAVLGVLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVA----FFtvltqIIWEATGEWVAGDVLCRIVKYL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  97 CGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAgiWVVSFLLATPVLVYRTVVALKTNMSLCYPKYPSKE 176
Cdd:cd14986   80 QVVGLFASTYILVSMSLDRYQAIVKPMSSLKPRKRARLMIVVA--WVLSFLFSIPQLVIFVERELGDGVHQCWSSFYTPW 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 177 HEAFHLIFEALTGFLLPFLAVVASY--------------SDIGRRLQARRFRRSRRTGRLVVL--------------IIL 228
Cdd:cd14986  158 QRKVYITWLATYVFVIPLIILSYCYgrilrtiwirsrqkTDRPIAPTAMSCRSVSCVSSRVSLisrakiktikmtlvIIL 237
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 966954328 229 AFAAFWLPYHVVNLAEAAralagqasgsGLVGQRLKLARSVLIALAFLSSSVNPVLY 285
Cdd:cd14986  238 AFILCWTPYFIVQLLDVY----------AGMQQLENDAYVVSETLASLNSALNPLIY 284
7tmA_CCR5_CCR2 cd15184
CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G ...
24-289 1.64e-13

CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR2 and CCR5 share very high amino acid sequence identity. Both receptors play important roles in the trafficking of monocytes/macrophages and are implicated in the pathogenesis of immunologic diseases (rheumatoid arthritis, celiac disease, and transplant rejection) and cardiovascular diseases (atherosclerosis and autoimmune hepatitis). CCR2 is a receptor specific for members of the monocyte chemotactic protein family, including CCL2, CCL7, and CCL13. Conversely, CCR5 is a major co-receptor for HIV infection and binds many CC chemokine ligands, including CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14, and CCL16. CCR2 is expressed primarily on blood monocytes and memory T cells, whereas CCR5 is expressed on antigen-presenting cells (macrophages and dendritic cells) and activated T effector cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341338 [Multi-domain]  Cd Length: 278  Bit Score: 69.78  E-value: 1.64e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  24 LLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQgTWSFGLAGCRLCHYVCGVSMYA 103
Cdd:cd15184    6 LYSLVFIFGFVGNMLVVLILINCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAAN-EWVFGNAMCKLLTGLYHIGFFS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 104 SVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYrTVVALKTNMSLCYPKYPSKEHE---AF 180
Cdd:cd15184   85 GIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVVTWVVAVFASLPGIIF-TKSQKEGSHYTCSPHFPPSQYQfwkNF 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 181 HLIFEALTGFLLPFLAVVASYSDI-GRRLQARRFRRSRRTGRLVVLIILAFAAFWLPYHVVNLAEAARALAGQASGSglV 259
Cdd:cd15184  164 QTLKMNILGLVLPLLVMIICYSGIlKTLLRCRNEKKRHKAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCS--S 241
                        250       260       270
                 ....*....|....*....|....*....|
gi 966954328 260 GQRLKLARSVLIALAFLSSSVNPVLYACAG 289
Cdd:cd15184  242 SNRLDQAMQVTETLGMTHCCINPVIYAFVG 271
7tmA_LPAR6_P2Y5 cd15156
lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G ...
24-195 1.89e-13

lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 6 (LPAR6), also known as P2Y5, is a G(i), G(12/13) G protein-coupled receptor that is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively present in serum. LPAR6 plays an important role in maintenance of human hair growth. Thus, mutations in the receptor are responsible for both autosomal recessive wooly hair and hypotrichosis. Phylogenetic analysis of the class A GPCRs shows that LAPR6 (P2Y5) is classified into the cluster consisting of receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production.


Pssm-ID: 320284 [Multi-domain]  Cd Length: 285  Bit Score: 69.88  E-value: 1.89e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  24 LLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYA 103
Cdd:cd15156    6 VFSMVFVLGLIANCVAIYIFMCTLKVRNETTTYMINLAISDLLFVFTLPFRIFYFVQRNWPFGDLLCKISVTLFYTNMYG 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 104 SVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALKTNMSL-CYPKYPSKEHEAFH- 181
Cdd:cd15156   86 SILFLTCISVDRFLAIVYPFRSKTLRTKRNAKIVCAAVWLTVLAGSLPASFFQSTNNQLNNNSEtCFENFSSKTWKTYLs 165
                        170
                 ....*....|....*.
gi 966954328 182 --LIFEALTGFLLPFL 195
Cdd:cd15156  166 kiVIFIEIVGFFIPLI 181
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
82-285 1.92e-13

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 70.11  E-value: 1.92e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  82 TWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARP--FVSQKLRTKAMALrvlaGIWVVSFLLATPVLVY---R 156
Cdd:cd15208   65 TWFFGQVLCKIIPYLQTVSVSVSVLTLSCIALDRWYAICHPlmFKSTAKRARVSIL----IIWIVSLLIMIPQAIVmecS 140
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 157 TVVALKTNMSL---CYPKYPSKEHEAFHLIFEALTGFLLPFLAVVASYSDI----------GRRLQARRFRRSRRTGR-- 221
Cdd:cd15208  141 RVVPLANKTILltvCDERWSDSIYQKVYHICFFLVTYLLPLCLMILAYFQIfrklwcrqipGTSSVVQRKWNKPRKSAva 220
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 222 --------------LVVLIILAFAAFWLPYHVVNLAEAARALagqasgsgLVGQRLKLARSVLIA--LAFLSSSVNPVLY 285
Cdd:cd15208  221 aeekqlrsrrktakMLIVVVIMFAICYLPVHLLNILRYVFGL--------FTVDRETIYAWFLFShwLVYANSAINPIIY 292
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
23-287 1.93e-13

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 69.77  E-value: 1.93e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  23 ILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALA-DLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVSM 101
Cdd:cd14992    5 VALVVIILVSVVGNFIVIAALARHKNLRGATNYFIASLAISdLLMALFCTPFNFTYVVSLSWEYGHFLCKIVNYLRTVSV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 102 YASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALKTNMSLCYPKY------PSK 175
Cdd:cd14992   85 YASSLTLTAIAFDRYFAIIHPLKPRHRQSYTTTVIIIITIWVVSLLLAIPQLYYATTEVLFSVKNQEKIFCcqippvDNK 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 176 EHEAFHLIFEALTGFLLPFLAVVASYSDIGR-------------RLQARRFRRSRRTGRLVVLIILAFAAFWLPYHVVNL 242
Cdd:cd14992  165 TYEKVYFLLIFVVIFVLPLIVMTLAYARISRelwfrkvpgfsikEVERKRLKCKRRVIKMLVCVVVLFVICWLPFHLFFL 244
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 966954328 243 AeaaralaGQASGSGLVGQRLKLARSVLIALAFLSSSVNPVLYAC 287
Cdd:cd14992  245 L-------RDFFPLIMKEKHTLQVYYFLHWIAMSNSMYNPIIYVT 282
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
19-198 1.98e-13

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 69.41  E-value: 1.98e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  19 LLAIILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQgTWSFGLAGCRLCHYVCG 98
Cdd:cd15923    1 LLQYAIYIPTFVLGLLLNILALWVFCWRLKKWTETNIYMTNLAVADLLLLISLPFKMHSYRR-ESAGLQKLCNFVLSLYY 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  99 VSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPvlvyRTVVALKTNMSLCYPKYPSKEHE 178
Cdd:cd15923   80 INMYVSIFTITAISVDRYVAIRYPLRARELRSPRKAAVVCAVIWVLVVTISIP----YFLLDSSNEKTMCFQRTKQTESL 155
                        170       180
                 ....*....|....*....|
gi 966954328 179 AFHLIFEALtGFLLPFLAVV 198
Cdd:cd15923  156 KVFLLLEIF-GFLLPLIIMT 174
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
24-285 2.36e-13

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 69.40  E-value: 2.36e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  24 LLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQG-TWSFGLAGCRLCHYVCGVSMY 102
Cdd:cd14991    6 LLILEFVLGLPGNVVALWIFCFHSRTWKANTVYLFNLVLADFLLLICLPFRIDYYLRGeHWIFGEAWCRVNLFMLSVNRS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 103 ASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVyRTVVALKTNMSLCYPKYPSKEHEAFHL 182
Cdd:cd14991   86 ASIAFLTAVALDRYFKVVHPHHRVNRMSVKAAAGVAGLLWALVLLLTLPLLL-STLLTVNSNKSSCHSFSSYTKPSLSIR 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 183 IFEALT--GFLLPFLAVVASYSDIGRRLQARRFRRSRR----TGRLVVLIILAFAAFWLPYHVVNLAEAARALAGQASGS 256
Cdd:cd14991  165 WHNALFllEFFLPLGLIVFCSVRIACNLRIRQSLGKQArvqrAIRLVFLVVIVFVLCFLPSIIAGLLALVFKNLGSCRCL 244
                        250       260
                 ....*....|....*....|....*....
gi 966954328 257 GLVGQRLklarSVLIALAFLSSSVNPVLY 285
Cdd:cd14991  245 NSVAQLF----HISLAFTYLNSALDPVIY 269
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
20-243 3.02e-13

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 69.31  E-value: 3.02e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  20 LAIILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALA-DLAVLLTAPF-FLHFLAQGTWSFGLAGCRLCHYVC 97
Cdd:cd15392    2 IIILMYSTIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSdILMAVFCVPFsFIALLILQYWPFGEFMCPVVNYLQ 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  98 GVSMYASVLLITAMSLDRSLAVARPFvsqKLR-TKAMALRVLAGIWVVSFLLATPVLVYRTV---VALKTNMSLCYPKYP 173
Cdd:cd15392   82 AVSVFVSAFTLVAISIDRYVAIMWPL---RPRmTKRQALLLIAVIWIFALATALPIAITSRLfedSNASCGQYICTESWP 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 174 SKEHEAFHLIFEALTGFLLPFLAVVASYSDIGRRLQAR-------------RFRRSRRTGRLVVLIILAFAAFWLPYHVV 240
Cdd:cd15392  159 SDTNRYIYSLVLMILQYFVPLAVLVFTYTRIGIVVWAKrtpgeaennrdqrMAESKRKLVKMMITVVAIFALCWLPLNIL 238

                 ...
gi 966954328 241 NLA 243
Cdd:cd15392  239 NLV 241
7tmA_PAR3 cd15371
protease-activated receptor 3, member of the class A family of seven-transmembrane G ...
27-204 4.54e-13

protease-activated receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320493 [Multi-domain]  Cd Length: 274  Bit Score: 68.67  E-value: 4.54e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  27 VALAVGLPGNSFVVWSILKRMkkRSVTALLVLNLALAD-LAVLLTAPFFLHFLAQGT-WSFGLAGCRLCHYVCGVSMYAS 104
Cdd:cd15371    9 IVVVLGVPSNAIILWMLFFRL--RSVCTAIFYANLAISdLLFCITLPFKIVYHLNGNnWVFGETMCRIITITFYGNMYCS 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 105 VLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATP-VLVYRTVVALKTNMSLCYPKYPSKEHEA---- 179
Cdd:cd15371   87 ILLLTCISINRYLAIVHPFIYRSLPKKTYAVLICALVWTIVFLYMLPfFILKQTYYLKELNITTCHDVLPECEQNSnfqf 166
                        170       180
                 ....*....|....*....|....*
gi 966954328 180 FHLIFEALTGFLLPFLAVVASYSDI 204
Cdd:cd15371  167 YYFISMAVFGFLIPLVITIFCYISI 191
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
19-286 4.59e-13

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 68.48  E-value: 4.59e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  19 LLAIILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCG 98
Cdd:cd15090    1 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGNILCKIVISIDY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  99 VSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALK--TNMSLCYPkYPSKE 176
Cdd:cd15090   81 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQgsIDCTLTFS-HPSWY 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 177 HEAFHLIFEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRR--------TGRLVVLIILAFAAFWLPYHVVNLAEAARA 248
Cdd:cd15090  160 WENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKekdrnlrrITRMVLVVVAVFIVCWTPIHIYVIIKALVT 239
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 966954328 249 LAGQASGSglvgqrlkLARSVLIALAFLSSSVNPVLYA 286
Cdd:cd15090  240 IPETTFQT--------VSWHFCIALGYTNSCLNPVLYA 269
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
17-239 5.36e-13

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 68.33  E-value: 5.36e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  17 IVLLAIILLSVAlavglpGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLA-QGTWSFGLAGCRLCHY 95
Cdd:cd16004    5 IAYSLIVLVAVT------GNATVIWIILAHRRMRTVTNYFIVNLALADLSMAAFNTAFNFVYAsHNDWYFGLEFCRFQNF 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  96 VCGVSMYASVLLITAMSLDRSLAVARPFvsqKLRTKAMALR-VLAGIWVVSFLLATPVLVYrTVVALKTNMSLCYPKYP- 173
Cdd:cd16004   79 FPITAMFVSIYSMTAIAADRYMAIIHPF---KPRLSAGSTKvVIAGIWLVALALAFPQCFY-STVTMDQGRTKCIVAWPg 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 174 ---SKEHEAFHLIFEALTgFLLPFLAVVASYSDIGRRLQARR-------------FRRSRRTGRLVVLIILAFAAFWLPY 237
Cdd:cd16004  155 dsgGKHQLTYHLAVIVLI-YLLPLAVMFVTYSIIGITLWRSAvpghqahgayhrqLQAKKKFVKTMVVVVVTFAICWLPY 233

                 ..
gi 966954328 238 HV 239
Cdd:cd16004  234 HL 235
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
83-288 6.06e-13

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 68.31  E-value: 6.06e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  83 WSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALK 162
Cdd:cd15097   67 WVFGSFLCKAVHFFIYLTMYASSFTLAAVSVDRYLAIRYPLRSRELRTPRNAVAAIALIWGLSLLFAGPYLSYYDLIDYA 146
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 163 tNMSLCYPKYPSKEHEAFHlIFEALTGFLLPFLAVVASYSD--------IGRRLQARRFRRSRRTGRLVVLIILA-FAAF 233
Cdd:cd15097  147 -NSTVCMPGWEEARRKAMD-TCTFAFGYLIPVLVVSLSYTRtikylwtaVDPLEAMSESKRAKRKVTKMIIIVTAlFCLC 224
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 966954328 234 WLPYHVVNLaeaaRALAGQASGSglvgQRLKLARSVLIALAFLSSSVNPVLYACA 288
Cdd:cd15097  225 WLPHHVVIL----CYLYGDFPFN----QATYAFRLLSHCMAYANSCLNPIVYALV 271
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
26-289 6.27e-13

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 68.15  E-value: 6.27e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  26 SVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQG-TWSFGLAGCRLCHYVCGVSMYAS 104
Cdd:cd15159    8 SLILVFGLLGNTLALHVICQKRKKINSTTLYLINLAVSDILFTLALPGRIAYYALGfDWPFGDWLCRLTALLFYINTYAG 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 105 VLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLvYRTVVALKTNMSLC--YPKYPSKEHEAFHL 182
Cdd:cd15159   88 VNFMTCLSVDRYIAVVHPLRRHRLRKVKVVRYICVFVWVLVFLQTLPLL-FMPMTKEMGGRITCmeYPNFEKIKRLPLIL 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 183 IFEALTGFLLPFLAVVASYSDIGRRLQARR--------FRRSRRTGRLVVLIILAFAAFWLPYHVVNLAEAARALAGQAS 254
Cdd:cd15159  167 LGACVIGFGVPVGIILFCYSQITLKLCRTAkenpltekSGHHKKACNVILLVLLVFVVCFSPYHLNIIQFMIRKLLYQPS 246
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 966954328 255 GSGLvgQRLKLARSVLIALAFLSSSVNPVLY--ACAG 289
Cdd:cd15159  247 CSEL--KAFKISLQITVCLMNLNCCLDPFIYffACKG 281
7tmA_P2Y4 cd15374
P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled ...
19-289 1.64e-12

P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y4 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320496 [Multi-domain]  Cd Length: 285  Bit Score: 67.14  E-value: 1.64e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  19 LLAIILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLA-QGTWSFGLAGCRLCHYVC 97
Cdd:cd15374    1 ILLPVSYGLVFVVGLPLNATALWLFIKRMRPWNPTTVYMFHLALSDTLYVLSLPTLIYYYAdHNHWPFGVVACKIVRFLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  98 GVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTvVALKTNMSLCYPKYPSKEH 177
Cdd:cd15374   81 YANLYCSILFLTCISVHRYVGICHPIRALRWVKPRHAYLICASVWLVVTVCLVPNLIFVT-TSRKDNITLCHDTTRPEEF 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 178 EAFHLIFEALTGFL--LPFLAVVASY--------SDIGRRLQARRFRRSRRTGRLVVLIILAFAAFWLPYHVV-NLAEAA 246
Cdd:cd15374  160 DHYVHYSSAVMVLLfgIPCLVIVVCYglmarrlcKPRVGSSRQQGPSSKKRSLKTIIMVLTVFAICFVPFHITrTLYYVA 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 966954328 247 RALAGQASGSGLVGQRLKLARsvliALAFLSSSVNPVLYACAG 289
Cdd:cd15374  240 RLLKADCDTLNIINVTYKVTR----PLASANSCLDPILYFLAG 278
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
23-201 2.10e-12

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 66.84  E-value: 2.10e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  23 ILLSVALAVGLPGNSFVVWsILKRMK--KRSVTALLVLNLALADLAVLLTAPFF-----LHFlaqgTWSFGLAGCRLCHY 95
Cdd:cd15926    5 IVYSVVCALGLVGNLLVLY-LMKSKQgwKKSSINLFVTSLAVTDFQFVLTLPFWavenaLDF----TWLFGKAMCKIVSY 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  96 VCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALkTNMSLCYPKYPSK 175
Cdd:cd15926   80 VTAMNMYASVFFLTAMSVARYHSVASALKSKRRRGCCSAKWLCVLIWVLAILASLPNAIFSTTATV-SNEELCLVKFPDN 158
                        170       180       190
                 ....*....|....*....|....*....|.
gi 966954328 176 EHEA-----FHLIFEALTGFLLPFLAVVASY 201
Cdd:cd15926  159 RGNAqfwlgLYHAQKVLLGFLIPLGIISLCY 189
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
18-242 2.15e-12

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 66.66  E-value: 2.15e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  18 VLLAIILLSVALaVGLPGNSFVVWSILKRMKKRSVTALLVLNLALA-DLAVLLTAPF-FLHFLAQgTWSFGLAGCRLCHY 95
Cdd:cd15393    1 VLLSILYGIISL-VAVVGNFLVIWVVAKNRRMRTVTNIFIANLAVAdIIIGLFSIPFqFQAALLQ-RWVLPRFMCPFCPF 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  96 VCGVSMYASVLLITAMSLDRSLAVARPFVSQKlrTKAMALRVLAGIWVVSFLLATPV-LVYRTV-VALKTNMSL---CYP 170
Cdd:cd15393   79 VQVLSVNVSVFTLTVIAVDRYRAVIHPLKARC--SKKSAKIIILIIWILALLVALPVaLALRVEeLTDKTNNGVkpfCLP 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 171 KYPS-KEHEAFHLIFeALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTG--------------RLVVLIILaFAAFWL 235
Cdd:cd15393  157 VGPSdDWWKIYNLYL-VCVQYFVPLVIICYAYTRIAVKIWGTKAPGNAQDVrddeilknkkkvikMLIIVVAL-FALCWL 234

                 ....*..
gi 966954328 236 PYHVVNL 242
Cdd:cd15393  235 PLQTYNL 241
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
22-286 2.33e-12

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 66.43  E-value: 2.33e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  22 IILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVSM 101
Cdd:cd15092    4 VVVYLIVCVVGLVGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDIFLGFWPFGNALCKTVIAIDYYNM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 102 YASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTvVALKTNMSLCYPKYPSKEH--EA 179
Cdd:cd15092   84 FTSTFTLTAMSVDRYVAICHPIKALDVRTPHKAKVVNVCIWALASVVGVPVMVMGS-AQVEDEEIECLVEIPTPQDywDP 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 180 FHLIFEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRR--------TGRLVVLIILAFAAFWLPYHVVNLAeaaralag 251
Cdd:cd15092  163 VFGICVFLFSFIIPVLIISVCYSLMIRRLRGVRLLSGSKekdrnlrrITRLVLVVVAVFVGCWTPIQIFVLA-------- 234
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 966954328 252 QASGSGLVGQRLKLARSVLIALAFLSSSVNPVLYA 286
Cdd:cd15092  235 QGLGVQPSSETAVAILRFCTALGYVNSSLNPVLYA 269
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
83-285 2.38e-12

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 66.59  E-value: 2.38e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  83 WSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVValk 162
Cdd:cd15134   67 WVFGEVFCKLRAFLSEMSSYASVLTITAFSVERYLAICHPLRSHTMSKLSRAIRIIIAIWIIAFVCALPFAIQTRIV--- 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 163 tnmslcYPKYPSKEHEAFH---------------LIFEALTG--FLLPFLAVVASYSDIGRRLQARRFRRSRRTGR---- 221
Cdd:cd15134  144 ------YLEYPPTSGEALEesafcamlneippitPVFQLSTFlfFIIPMIAIIVLYVLIGLQLRRSTLLRRGQRSVsggr 217
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966954328 222 -----------LVVLIILAFAAFWLPYHvvnlaeAARALAGQASGSglvGQRLKLARSVLIALA----FLSSSVNPVLY 285
Cdd:cd15134  218 rssqsrrtvlrMLVAVVVAFFICWAPFH------AQRLLTVYAKNM---TPPYLFINRILFYISgvlyYVSSTVNPILY 287
7tmA_GPR132_G2A cd15364
proton-sensing G protein-coupled receptor 132, member of the class A family of ...
22-285 2.82e-12

proton-sensing G protein-coupled receptor 132, member of the class A family of seven-transmembrane G protein-coupled receptors; The G2 accumulation receptor (G2A, also known as GPR132) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. G2A was originally identified as a stress-inducible receptor that causes the cell cycle arrest at G2/M phase when serum is deprived. Lysophosphatidylcholine was identified as a ligand for G2A, and whose overexpression was shown to induce cell proliferation, oncogenic transformation, and apoptosis.


Pssm-ID: 320486 [Multi-domain]  Cd Length: 279  Bit Score: 66.34  E-value: 2.82e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  22 IILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLA-QGTWSFGLAGCRLCHYVCGVS 100
Cdd:cd15364    4 VVVYSVVFALGFPANCLTLWLTLLQVRRKNVLAVYLFSLSLCELLYLGTLPLWTIYVSnNHKWPWGSLACKITGYIFFCN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 101 MYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTvvALKTNMSLCYPKYPSKEHEAF 180
Cdd:cd15364   84 IYISILLLCCISIDRFVAVVYALESRGRRRQRIAAFISFLIFIVVGLVHSPVFIMRE--GQTEGSHTCFETLQMDTQVAG 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 181 HLIFEALTGFLLPFLAVVASYSDIGRRLQARRFRRS---RRTGRLVVLIILAFAAFWLPYHVVNLAEAArALAGQASGSG 257
Cdd:cd15364  162 FYYARFCIGFAIPLAILIFTNYRIFRSIQTSTSLTPhqkAKVKYLAIAVIVIFLICFAPYHLVLLVRAI-AFSLYPNGMC 240
                        250       260
                 ....*....|....*....|....*...
gi 966954328 258 LVGQRLKLARSVLIALAFLSSSVNPVLY 285
Cdd:cd15364  241 GFEERIYTPSVIFLCLSTVNSVADPIIY 268
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
23-242 3.43e-12

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 66.08  E-value: 3.43e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  23 ILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALA-DLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVSM 101
Cdd:cd14969    5 VYLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALAdLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAVTFLG 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 102 YASVLLITAMSLDRSLAVARPFVSQKLRTKaMALRVLAGIWVVSFLLATPVLV----YrTVVALKTNmslCYPKYPSKEH 177
Cdd:cd14969   85 LVSISTLAALAFERYLVIVRPLKAFRLSKR-RALILIAFIWLYGLFWALPPLFgwssY-VPEGGGTS---CSVDWYSKDP 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 178 EA-----FHLIFealtGFLLPFLAVVASYSDI---------------GRRLQARRFRRSRRTGRLVVLIILAFAAFWLPY 237
Cdd:cd14969  160 NSlsyivSLFVF----CFFLPLAIIIFCYYKIyrtlrkmskraarrkNSAITKRTKKAEKKVAKMVLVMIVAFLIAWTPY 235

                 ....*
gi 966954328 238 HVVNL 242
Cdd:cd14969  236 AVVSL 240
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
83-285 5.69e-12

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 65.68  E-value: 5.69e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  83 WSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTV---- 158
Cdd:cd15131   66 WNFGDLLCKLFQFVSESCTYSTILNITALSVERYFAICFPLRAKVVVTKRRVKLVILVLWAVSFLSAGPIFVLVGVehen 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 159 --VALKTNMslCYP-KYPSKEHEAFHLIFEALTGFLLPFLAVVASYSDIG-----------RRLQARRFRRSRRTGRLVV 224
Cdd:cd15131  146 gtNPIDTNE--CKAtEYAVRSGLLTIMVWVSSVFFFLPVFCLTVLYSLIGrklwrrrreniGPNASHRDKNNRQTVKMLA 223
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966954328 225 LIILAFAAFWLPYHVvnlaeaARALAGQAS--GSGLVGQRLKLARSVLIALAFLSSSVNPVLY 285
Cdd:cd15131  224 VVVFAFVLCWLPFHV------GRYLFSKSFeaGSLEIALISQYCNLVSFVLFYLSAAINPILY 280
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
18-285 5.89e-12

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 65.45  E-value: 5.89e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  18 VLLAIILLSVALaVGLPGNSFVVWSILKRMKKRS-VTALLVLNLALADLAVLLTAPF-FLHFLAQGTWSFGLAGCRLCHY 95
Cdd:cd14979    1 VLVTAIYVAIFV-VGIVGNLLTCIVIARHKSLRTtTNYYLFSLAVSDLLILLVGLPVeLYNFWWQYPWAFGDGGCKLYYF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  96 VCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVAL-------KTNMSLC 168
Cdd:cd14979   80 LFEACTYATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAIPILFLMGIQYLngplpgpVPDSAVC 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 169 ypkYPSKEHEAFHLIFE--ALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGR-------------------LVVLII 227
Cdd:cd14979  160 ---TLVVDRSTFKYVFQvsTFIFFVLPMFVISILYFRIGVKLRSMRNIKKGTRAQgtrnvelslsqqarrqvvkMLGAVV 236
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 966954328 228 LAFAAFWLPYHvvnlaeAARALAGQASGSGLVGQRL-KLARSVLIALAFLSSSVNPVLY 285
Cdd:cd14979  237 IAFFVCWLPFH------AQRLMFSYASKEDTFLFDFyQYLYPISGILFYLSSAINPILY 289
7tmA_P2Y3-like cd16001
P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G ...
26-290 6.12e-12

P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y3-like proteins are an uncharacterized group that belongs to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320667 [Multi-domain]  Cd Length: 284  Bit Score: 65.17  E-value: 6.12e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  26 SVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFF-LHFLAQGTWSFGLAGCRLCHYVCGVSMYAS 104
Cdd:cd16001    8 SVVFVLGLPLNGTVLWLSWCRTKRWTCSTIYLVNLAVADLLYVCSLPLLiVNYAMRDRWPFGDFLCKLVRFLFYTNLYGS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 105 VLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALkTNMSLCYPKYPSKEHEAFHLIF 184
Cdd:cd16001   88 ILFLTCISVHRFLGVCYPIRSLAYRTRRLAVIGSAATWILVVLQLLPTLVYARTGSI-NNRTVCYDLTSPDNFGNYFPYG 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 185 EALT--GFLLPFLAVVASYSDI------GRRLQARRFRRSRRTGRLVVLIILAFAAFWLPYHV---------VNLAEAAR 247
Cdd:cd16001  167 MVLTvtGFLIPFLIILLCYCLMikslirSEEAAGVGKAARAKSIRTILLVCGLFALCFVPFHItrtiylfvrVYLVQDCP 246
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 966954328 248 ALagqasgsglvgQRLKLARSVLIALAFLSSSVNPVLYACAGG 290
Cdd:cd16001  247 LL-----------QFVSLAYKIWRPLVSFNSCINPLLYFLSGD 278
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
76-287 1.42e-11

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 64.00  E-value: 1.42e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  76 HFLAQGtWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATP-VLV 154
Cdd:cd15012   59 IYLIPS-WPFGEVLCRMYQFVHSLSYTASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNTPyFVF 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 155 YRTVVALKTNMSLCYPKYPSKEHEAFHLIFEA---LTGFLLPFLAVVASYSDIGRRLQARRFRRS-RRTGRLVVLIILAF 230
Cdd:cd15012  138 SQTVEILVTQDGQEEEICVLDREMFNSKLYDTinfIVWYLIPLLIMTVLYSKISIVLWKSSSIEArRKVVRLLVAVVVSF 217
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 966954328 231 AAFWLPYHVVNLAEAARALAGQASGSGLVGQRLKLarsvliALAFLSSSVNPVLYAC 287
Cdd:cd15012  218 ALCNLPYHARKMWQYWSEPYRCDSNWNALLTPLTF------LVLYFNSAVNPLLYAF 268
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
19-240 1.83e-11

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 63.90  E-value: 1.83e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  19 LLAIILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALA-DLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVC 97
Cdd:cd15389    1 ALLIVAYSIIIVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSdILITLLNTPFTLVRFVNSTWVFGKIMCHLSRFAQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  98 GVSMYASVLLITAMSLDRSLAVARPFvsqKLR-TKAMALRVLAGIWVVSFLLATPVLVYRTVVALK----TNMSLCYPKY 172
Cdd:cd15389   81 YCSVYVSTLTLTAIALDRHRVILHPL---KPRiTPCQGVVVIAIIWIMASCLSLPHAIYQKLVEFEysneRTRSRCLPSF 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 173 P--SKEHEAFHLIFEALTGFLLPFLAVVASYS-------------DIGRRLQARRFRRSRRTGRLVVLIILAFAAFWLP- 236
Cdd:cd15389  158 PepSDLFWKYLDLATFILQYVLPLLIIGVAYTrvakklwlrnaigDVTTEQYVAQRRKKKKTIKMLMLVVLLFAICWLPl 237

                 ....*.
gi 966954328 237 --YHVV 240
Cdd:cd15389  238 ncYHVL 243
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
20-287 2.28e-11

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 63.14  E-value: 2.28e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  20 LAIILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALA-DLAVLLTAPF-FLHFLAQGTWSFGLAGCRLCHYVC 97
Cdd:cd15067    1 LLGVVLSLFCLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVAdLLVGSIVMPFsILHEMTGGYWLFGRDWCDVWHSFD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  98 GVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVAlktnmslcyPKYPSKEH 177
Cdd:cd15067   81 VLASTASILNLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWICSALISFPAIAWWRAVD---------PGPSPPNQ 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 178 EAF-----HLIFEALTGFLLPFLAVVASYSDIgrrlqARRFRRSRRTGRLVVLIILAFAAFWLPYHVVNLAEAaralagq 252
Cdd:cd15067  152 CLFtddsgYLIFSSCVSFYIPLVVMLFTYYRI-----YRAAAKEQKAAKTLGIVMGVFILCWLPFFVTNILIG------- 219
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 966954328 253 ASGSGLVgQRLKLARSVLIALAFLSSSVNPVLYAC 287
Cdd:cd15067  220 FCPSNCV-SNPDILFPLVTWLGYINSGMNPIIYAC 253
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
81-286 2.35e-11

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 63.51  E-value: 2.35e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  81 GTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVA 160
Cdd:cd15083   64 GRWIFGKTGCDMYGFSGGLFGIMSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLLWVLPPLFGWSRYV 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 161 LKTNMSLCYPKYPSKEHEA-FHLIFEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLV---------------- 223
Cdd:cd15083  144 LEGLLTSCSFDYLSRDDANrSYVICLLIFGFVLPLLIIIYCYSFIFRAVRRHEKAMKEMAKRFSkselsspkarrqaevk 223
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966954328 224 -----VLIILAFAAFWLPYHVVnlaeaarALAGQASGSGLVGqrlKLARSVLIALAFLSSSVNPVLYA 286
Cdd:cd15083  224 takiaLLLVLLFCLAWTPYAVV-------ALIGQFGYLEVLT---PLATAIPAAFAKTSAIYNPVIYA 281
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
26-287 2.63e-11

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 63.35  E-value: 2.63e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  26 SVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFF-LHFLAQGTWSFGLAGCRLCHYVCGVSMYAS 104
Cdd:cd16002    8 SVIVVVSVVGNIIVMWIILAHKRMRTVTNYFLVNLAFAEASMSAFNTVInFTYAIHNEWYYGLEYCKFHNFFPIAAVFAS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 105 VLLITAMSLDRSLAVARPFvsqKLRTKAMALRVLAG-IWVVSFLLATPVLVYRTVVALKTNMsLCY---PKYPSKEHE-A 179
Cdd:cd16002   88 IYSMTAIALDRYMAIIHPL---QPRLSATATKVVICvIWVLAFLLAFPQGYYSDTEEMPGRV-VCYvewPEHEERKYEtV 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 180 FHLIFEALTgFLLPFLAVVASYSDIGRRLQAR------------RFRRSRRTGRLVVLIILAFAAFWLPYHVVNLAeaar 247
Cdd:cd16002  164 YHVCVTVLI-YFLPLLVIGCAYTVVGITLWASeipgdssdryheQVSAKRKVVKMMIVVVCTFAICWLPYHIYFLL---- 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 966954328 248 alagQASGSGLVGQrlKLARSVLIA---LAFLSSSVNPVLYAC 287
Cdd:cd16002  239 ----QYFHPELYEQ--KFIQQVYLAimwLAMSSTMYNPIIYCC 275
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
17-286 3.04e-11

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 63.26  E-value: 3.04e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  17 IVLLAIILLSVALAvgLPGNSFVVWSILKRMKKRSVTALLVLNLALA-DLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHY 95
Cdd:cd15205    1 TAFVITYVLIFVLA--LFGNSLVIYVVTRKRAMRTATNIFICSLALSdLLITFFCIPFTLLQNISSNWLGGAFMCKMVPF 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  96 VCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVyrtVVALKTNMSL-------- 167
Cdd:cd15205   79 VQSTAVVTSILTMTCIAVERHQGIVHPLKMKWQYTNRRAFTMLGLVWIVSVIVGSPMLF---VQQLEVKYDFlyekrhvc 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 168 CYPKYPSKEHEAFHLIFEALTGFLLPFLAVVASYSDIG-------------------RRLQARRFRRSRRTGRLVVLIIL 228
Cdd:cd15205  156 CLERWYSPTQQKIYTTFILVILFLLPLTTMLFLYSRIGyelwikkrvgdasvlqtihGIEMSKISRKKKRAVKMMVTVVL 235
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 966954328 229 AFAAFWLPYHVVNLAEAARALAGQasgsgLVGQRLKLARSVLIALAFLSSSVNPVLYA 286
Cdd:cd15205  236 LFAVCWAPFHVVHMMIEYSNLENK-----YDGVTIKLIFAIVQLIGFSNSFNNPIVYA 288
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
18-204 1.00e-10

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 61.71  E-value: 1.00e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  18 VLLAIILLSVALaVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGT-WSFGLAGCRLCHYV 96
Cdd:cd15368    1 VILPVVYSLVAL-ISIPGNLFSLWLLCFHTKPKTPSIIFMINLSLTDLMLACFLPFQIVYHIQRNhWIFGKPLCNVVTVL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  97 CGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALKT-NMSLCY-----P 170
Cdd:cd15368   80 FYANMYSSILTMTCISIERYLGVVYPMRSMRWRKKRYAVAACIGMWLLVLTALSPLERTDLTYYVKElNITTCFdvlkwT 159
                        170       180       190
                 ....*....|....*....|....*....|....
gi 966954328 171 KYPSKEHEAFHLIFEALTGFLLPFLAVVASYSDI 204
Cdd:cd15368  160 MLPNIAAWAAFLFTLFILLFLIPFIITVYCYVLI 193
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
22-294 1.01e-10

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 61.48  E-value: 1.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  22 IILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLltapfFLHFLAQGTWSF------GLAGCRLCHY 95
Cdd:cd15196    4 IAVLATILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVA-----LFNVLPQLIWDItyrfygGDLLCRLVKY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  96 VCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVlAGIWVVSFLLATPVLVYRTVVALKTNMSLCYPKYPSK 175
Cdd:cd15196   79 LQVVGMYASSYVLVATAIDRYIAICHPLSSHRWTSRRVHLMV-AIAWVLSLLLSIPQLFIFSYQEVGSGVYDCWATFEPP 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 176 EHEAFHLIFEALTGFLLPFLAVVASYSDIgrrlQARRFRRSRRTGRLVVLIILAFAAFWLPYHVVNLAEAARALAgQASG 255
Cdd:cd15196  158 WGLRAYITWFTVAVFVVPLIILAFCYGRI----CYVVWRAKIKTVKLTLVVVACYIVCWTPFFVVQMWAAWDPTA-PIEG 232
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 966954328 256 SGLVgqrlklarsVLIALAFLSSSVNPVLYACAGGGLLR 294
Cdd:cd15196  233 PAFV---------IIMLLASLNSCTNPWIYLAFSGNLRR 262
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
76-289 1.14e-10

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 61.27  E-value: 1.14e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  76 HFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVvsFLLATPVLVY 155
Cdd:cd15157   59 YYLMGSHWVFGDIACRIMSYSLYVNMYCSIYFLTVLSIVRFLAIVHPFKLWKVTSIKYARILCAVIWI--FVMAASSPLL 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 156 RTVVALKTNMSLCYPKYPSKEHEAFHLIFEAL-TGFLLPFLAVVASYSDI------GRRLQARRFRRSRRTGRLVVLIIL 228
Cdd:cd15157  137 SKGTSKYNSQTKCLDLHPSKIDKLLILNYIVLvVGFILPFCTLSICYILIikallkPRVPQSKLRVSHKKALLTIIITLI 216
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 966954328 229 AFAAFWLPYHVVnlaeaaRALAGQASGSGLVGQRLKLARSVLIALAFLSSSVNPVLYACAG 289
Cdd:cd15157  217 LFLLCFLPYHIL------RTVHLMQWSEGQCNLRLHKAVVITLCLAAANSCLDPLLYYFAG 271
7tmA_OXGR1 cd15375
2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G ...
31-239 1.50e-10

2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; 2-oxoglutarate receptor 1 (OXGR1) is also known as GPR80, GPR99, or P2Y15. OXGR1 functions as a receptor for alpha-ketoglutarate, a citric acid cycle intermediate, and acts exclusively through a G(q)-dependent pathway. OXGR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC). OXGR1 has also been reported as a potential third cysteinyl leukotriene receptor with specificity for leukotriene E4.


Pssm-ID: 320497 [Multi-domain]  Cd Length: 280  Bit Score: 61.24  E-value: 1.50e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  31 VGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQG-TWSFGLAGCRLCHYVCGVSMYASVLLIT 109
Cdd:cd15375   13 VGFPGNIIAIFVYLFKMRPWKSSTIIMLNLALTDLLYVTSLPFLIYYYINGeSWIFGEFMCKFIRFIFHFNLYGSILFLT 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 110 AMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVAlKTNMSLCYPKYPSKEHEA---FHLIFEA 186
Cdd:cd15375   93 CFSIFRYVVIVHPLRAFQVQKRRWAIVACAVVWVISLAEVSPMTFLITTKE-KNNRTICLDFTSSDNLNTiwwYNWILTV 171
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 966954328 187 LtGFLLPFLAVVASYSDIGRRLQA---RRFRRSRRTGRLVVLIILAFAAFWLPYHV 239
Cdd:cd15375  172 L-GFLLPLVIVTLCYTRIIYTLAKgphTGSASKQKARRLIILILLVFYVCFLPFHI 226
7tmA_PAR1 cd15369
protease-activated receptor 1, member of the class A family of seven-transmembrane G ...
31-204 1.51e-10

protease-activated receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320491  Cd Length: 281  Bit Score: 61.32  E-value: 1.51e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  31 VGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGT-WSFGLAGCRLCHYVCGVSMYASVLLIT 109
Cdd:cd15369   13 ISLPLNILALVVFLRKMRVKKPAVIYMLNLACADLLFVLLLPFKIAYHFSGNdWLFGEAMCRVVTAAFYCNMYCSILLMT 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 110 AMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALK-TNMSLCYPKYPSKEHEAFHL----IF 184
Cdd:cd15369   93 CISVDRFLAVVYPMQSLSWRTLRRASFTCAAIWLLSIAGVVPLLLSEQTIQIPdLGITTCHDVLNEQLLMGYYVyyfsIF 172
                        170       180
                 ....*....|....*....|
gi 966954328 185 EALTgFLLPFLAVVASYSDI 204
Cdd:cd15369  173 SCLF-FFVPLIITTVCYVSI 191
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
81-285 1.84e-10

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 60.90  E-value: 1.84e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  81 GTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARP--FVSQKLRTKAMalrvLAGIWVVSFLLATPVLVYRTV 158
Cdd:cd15197   64 VEWRAGDFACKVIRYLQVVVTYASTYVLVALSIDRYDAICHPmnFSQSGRQARVL----ICVAWILSALFSIPMLIIFEK 139
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 159 VALKTNMSLCYPKYPSKEHEAFHLIFEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGR----------------- 221
Cdd:cd15197  140 TGLSNGEVQCWILWPEPWYWKVYMTIVAFLVFFIPATIISICYIIIVRTIWKKSKIQVTINKAglhdgssrrsssrgiip 219
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966954328 222 --------LVVLIILAFAAFWLPYHVVNLAEAAralagqasgSGLVGQRLKLARSVLI-ALAFLSSSVNPVLY 285
Cdd:cd15197  220 rakiktikMTFVIVTVFIICWSPYFVFDLLDVF---------GLLPRSKTKIAAATFIqSLAPLNSAINPLIY 283
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
26-289 2.05e-10

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 60.92  E-value: 2.05e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  26 SVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGtWSFGLAGCRLCHYVCGVSMYASV 105
Cdd:cd15181    8 SLVFLLGVVGNGLVLTILLRRRRSRRTTENYLLHLALADLLLLLTFPFSVVESIAG-WVFGTFLCKLVGAIHKLNFYCSS 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 106 LLITAMSLDRSLAVARPFVS-QKLRTKAMALRVLaGIWVVSFLLATPVLVYRTV-VALKTNMSLCYpkYPSKEHEAFHLI 183
Cdd:cd15181   87 LLLACISVDRYLAIVHAIHSyRHRRLRSVHLTCG-SIWLVCFLLSLPNLVFLEVeTSTNANRTSCS--FHQYGIHESNWW 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 184 FEA-----LTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGR-LVVLIILAFAAFWLPYHVVNLAEAARALAGQASGSG 257
Cdd:cd15181  164 LTSrflyhVVGFFLPLLIMGYCYATIVVTLCQSSRRLQKQKAIrVAILVTLVFCLCWLPYNIVIFLDTLDDLKAVVKNCK 243
                        250       260       270
                 ....*....|....*....|....*....|..
gi 966954328 258 LVGQrLKLARSVLIALAFLSSSVNPVLYACAG 289
Cdd:cd15181  244 LNDL-LDAAITVTESLGFSHCCLNPILYAFIG 274
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
83-204 3.26e-10

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 60.07  E-value: 3.26e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  83 WSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAgiWVVSFLLATPVLV-YRTVVAL 161
Cdd:cd15383   67 WYAGDLACRLLMFLKLFAMYSSAFVTVVISLDRHAAILNPLAIGSARRRNRIMLCAA--WGLSALLALPQLFlFHTVTAT 144
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 966954328 162 K-TNMSLCYPK--YPSKEHEAFHLIFEALTGFLLPFLAVVASYSDI 204
Cdd:cd15383  145 PpVNFTQCATHgsFPAHWQETLYNMFTFFCLFLLPLLIMIFCYTRI 190
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
19-286 3.36e-10

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 59.82  E-value: 3.36e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  19 LLAIILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALA-DLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVC 97
Cdd:cd15063    1 LISLLVLTFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACAdLLVGTLVLPFSAVNEVLDVWIFGHTWCQIWLAVD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  98 GVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVY---RTVVALKTNMSLCYPKYPS 174
Cdd:cd15063   81 VWMCTASILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSFVICFPPLVGwndGKDGIMDYSGSSSLPCTCE 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 175 KEHEAFHLIFEALTGFLLPFLAVVASYSDIgrrlqARRFRRSRRTGRLVVLIILAFAAFWLPYHVVNLAEAARALAGQas 254
Cdd:cd15063  161 LTNGRGYVIYSALGSFYIPMLVMLFFYFRI-----YRAARMETKAAKTVAIIVGCFIFCWLPFFTVYLVRAFCEDCIP-- 233
                        250       260       270
                 ....*....|....*....|....*....|..
gi 966954328 255 gsglvgqrlKLARSVLIALAFLSSSVNPVLYA 286
Cdd:cd15063  234 ---------PLLFSVFFWLGYCNSALNPCIYA 256
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
72-243 4.95e-10

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 59.60  E-value: 4.95e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  72 PFFL--HFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMAlrVLAGIWVVSFLLA 149
Cdd:cd15204   55 PFEMdyYVVRQRSWTHGDVLCAVVNYLRTVSLYVSTNALLVIAIDRYLVIVHPLKPRMKRRTACV--VIALVWVVSLLLA 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 150 TPVLVY-RTVVALKTNMSLC---YPKYPSKEHEAFHLIFEALTgFLLPFLAVVASYSDIGR------------RLQARRF 213
Cdd:cd15204  133 IPSAVYsKTTPYANQGKIFCgqiWPVDQQAYYKAYYLFLFVLE-FVLPVLIMTLCYLRIVRkvwfrrvpgqqtEQIRRRL 211
                        170       180       190
                 ....*....|....*....|....*....|
gi 966954328 214 RRSRRTGRLVVLIILAFAAFWLPYHVVNLA 243
Cdd:cd15204  212 RRRRRKVRLLVVILTAFVLCWAPYYGYAIV 241
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
19-287 6.11e-10

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 59.33  E-value: 6.11e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  19 LLAIILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLltapfFLHFLAQGTWSFG---LAG---CRL 92
Cdd:cd15195    1 LVRVLVTWVLFVISAAGNLTVLIQLFRRRRAKSHIQILIMHLALADLMVT-----FFNMPMDAVWNYTvewLAGdlmCRV 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  93 CHYVCGVSMYASVLLITAMSLDRSLAVARPFV--SQKLRTKAMalrvLAGIWVVSFLLATPVLVYRTVVALKT---NMSL 167
Cdd:cd15195   76 MMFLKQFGMYLSSFMLVVIALDRVFAILSPLSanQARKRVKIM----LTVAWVLSALCSIPQSFIFSVLRKMPeqpGFHQ 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 168 C--YPKYPSKEHEAFHLIFEALTGFLLPFLAVVASYSDI-------------------GRRLQARRFRRSRRTGRLVVLI 226
Cdd:cd15195  152 CvdFGSAPTKKQERLYYFFTMILSFVIPLIITVTCYLLIlfeiskmakrardtpisnrRRSRTNSLERARMRTLRMTALI 231
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 966954328 227 ILAFAAFWLPYHVVNLAEAARALAGQASGSGLVGqrlklarsVLIALAFLSSSVNPVLYAC 287
Cdd:cd15195  232 VLTFIVCWGPYYVLGLWYWFDKESIKNLPPALSH--------IMFLLGYLNPCLHPIIYGV 284
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
20-285 6.54e-10

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 59.39  E-value: 6.54e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  20 LAIILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGV 99
Cdd:cd15154    2 LHLVGYSLLFPVGLLLNAVALWVFVRYLRLHSVVSIYMCNLALSDLLFTLSLPLRIYYYANHYWPFGNFLCQFSGSIFQM 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 100 SMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPV-LVYRTVVALKTN--MSLCYPKYPSKE 176
Cdd:cd15154   82 NMYGSCLFLMCINVDRYLAIVHPLRFRHLRRPKVARLLCLAVWALILGGSVPAaIVHSSSDCLLHGekVYRCFESFSDND 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 177 H-EAFHLIFEA-LTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIIL---AFAAFWLPYHVVnLAEAARALAG 251
Cdd:cd15154  162 WkGLLPLVVLAeILGFLLPLAAVLYCSCRIFVELCRTQEPQQGRRRKTVRLLLVnlvIFLICFVPYNTT-LAVYGLLRAN 240
                        250       260       270
                 ....*....|....*....|....*....|....
gi 966954328 252 QASGSGLVGQRLKLARSVLIALAFLSSSVNPVLY 285
Cdd:cd15154  241 LVEDTWNIKDTLRKVLSVTVLLASTNCALDPLVY 274
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
72-286 7.50e-10

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 58.91  E-value: 7.50e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  72 PFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATP 151
Cdd:cd15061   54 PLAIIRQLLGYWPLGSHLCDFWISLDVLLCTASILNLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVISLLITSP 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 152 VLVYRTVVALKTNMSLCYPKYPSkeheafHLIFEALTGFLLPFLAVVASYSDIgrrlqARRFRRSRRTGRLVVLIILAFA 231
Cdd:cd15061  134 PLVGPSWHGRRGLGSCYYTYDKG------YRIYSSMGSFFLPLLLMLFVYLRI-----FRVIAKERKTAKTLAIVVGCFI 202
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 966954328 232 AFWLPYHVVNLAEAarALAGQASgsglvgQRLKLArsvLIALAFLSSSVNPVLYA 286
Cdd:cd15061  203 VCWLPFFIMYLIEP--FCDCQFS------EALSTA---FTWLGYFNSVINPFIYA 246
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
83-201 7.60e-10

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 59.19  E-value: 7.60e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  83 WSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQK----LRTKAMALrvlaGIWVVSFLLATPVLVYRTV 158
Cdd:cd15125   66 WMFGTVGCKLIPVIQLTSVGVSVFTLTALSADRYKAIVNPMDIQTssavLRTCLKAI----AIWVVSVLLAVPEAVFSEV 141
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 966954328 159 VAL----KTNMSLCYPkYPSKE--HEAFHLIFEALTGFLLPfLAVVASY 201
Cdd:cd15125  142 AHImpddNTTFTACIP-YPQTDemHPKIHSVLIFLVYFLIP-LAIISIY 188
7tmA_P2Y6 cd15379
P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled ...
19-285 7.87e-10

P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes mammalian P2Y6, avian P2Y3, and similar proteins. P2Y3 is the avian homolog of mammalian P2Y6. They belong to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320501 [Multi-domain]  Cd Length: 288  Bit Score: 59.12  E-value: 7.87e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  19 LLAIILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGT-WSFGLAGCRLCHYVC 97
Cdd:cd15379    1 VLLPLVYSVVFLLGLPLNAVVIGQIWATRQALSRTTIYMLNLATADLLYVCSLPLLIYNYTQKDyWPFGDFTCRLVRFQF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  98 GVSMYASVLLITAMSLDRSLAVARPFVS-QKLRTKAMALRVLAGIWVVSFLLATPVLVYRTvVALKTNMSLCYPKYPSKE 176
Cdd:cd15379   81 YTNLHGSILFLTCISVQRYLGICHPLASwHKKKGKKLTWLVCGAVWLVVIAQCLPTFVFAS-TGTQRNRTVCYDLSPPAR 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 177 HEAFHLIFEALT--GFLLPFLAVVASY---------SDIGRRLQARRFRRSRRTGRLVVLIILAFAAFWLPYHVVNLA-E 244
Cdd:cd15379  160 STAYFPYGITLTrtGFLLPFAARLACYcsmatilcrVVIAVAVVAAPGEKRGKAARMIIVVAAVFLISFLPFHYTKTRyL 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 966954328 245 AARALAGQASGsglVGQRLKLARSVLIALAFLSSSVNPVLY 285
Cdd:cd15379  240 QVRSWDGGPCT---TRQAFAEAYKRTRPFASMNSVLDPILF 277
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
19-242 7.88e-10

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 59.12  E-value: 7.88e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  19 LLAIILLSVALAVGLPGNSFVVWSI-LKRMKKRSVTALLVLNLALADLAVLLTAPFF-LHFLAQGTWSFGLAGCRLCHYV 96
Cdd:cd15925    1 ILVALAYGLVCAIGLLGNLAVMYLLrNCARRAPPPIDVFVFNLALADFGFALTLPFWaVESALDFHWPFGGAMCKMVLTA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  97 CGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALkTNMSLCYPKYPSKE 176
Cdd:cd15925   81 TVLNVYASVFLLTAMSVTRYWVVASAAGPGTHLSTFWAKIITLALWAAALLATVPTAIFATEGEV-CGVELCLLKFPSNY 159
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 966954328 177 HEAFHLIFEALTGFLLPFLAVVASYSDIGRRLQARRFRR-----SRRTGRLVVLIILAFAAFWLPYHVVNL 242
Cdd:cd15925  160 WLGAYHLQRVVVAFVVPLGVITTSYLLLLSFLQQHKVNQnnrqrQSVIARSVRLVVASFFLCWFPNHVVTF 230
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
26-202 1.02e-09

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 58.78  E-value: 1.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  26 SVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYASV 105
Cdd:cd15155    8 SVVFILGLITNCASLFVFCFRMKMRNETAIFMTNLAVSDLLFVFTLPFKIFYNFNRHWPFGDSLCKISGTAFLTNIYGSM 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 106 LLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALKTNMSlCYPKYPS---KEHEAFHL 182
Cdd:cd15155   88 LFLTCISVDRFLAIVYPFRSRTIRTRRNSAIVCAGVWILVLSGGISASLFSTTNVSNTSTT-CFEGFSKsiwKTYLSKIT 166
                        170       180
                 ....*....|....*....|
gi 966954328 183 IFEALTGFLLPFLAVVASYS 202
Cdd:cd15155  167 IFIEVVGFIIPLLLNLTCSS 186
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
31-285 1.08e-09

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 58.55  E-value: 1.08e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  31 VGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPF-FLHFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLIT 109
Cdd:cd15967   13 VGLVGNVWGLKSLLANWKKLGNINVFVLNLGLADLLYLLTLPFlVVYYLKGRKWIFGQVFCKITRFCFNLNLYGSIGFLT 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 110 AMSLDRSLAVARPF-VSQKLRTKAMALrVLAGIWVVSFLLATPVLVYrtvvaLKT--NMSLCYPKYPSKEHEAF--HLIF 184
Cdd:cd15967   93 CISVYRYLAIVHPMrVMGRITTTHSVV-ISALVWLLVVIQSLPDLFF-----SKTnsNGTKCFDTTFNDYLESYltYSLG 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 185 EALTGFLLPFLAVVASYSDIGRRLQARRFRRSRR---TGRLVVLIILAFAAFWLPYHVV-NLAEAARALAGQasgsglvG 260
Cdd:cd15967  167 WTVTGFVIPLLIILGCYGHVVVVLCRNNNVDKGLkqrCLKLVIILIVLFSVCYIPYHVFrNLNLLSRILQKQ-------G 239
                        250       260       270
                 ....*....|....*....|....*....|.
gi 966954328 261 QRLKLARSVLIA------LAFLSSSVNPVLY 285
Cdd:cd15967  240 SCTQWFRGIYIAhqvsrgLVCLNSALNPLVY 270
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
21-287 1.43e-09

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 58.20  E-value: 1.43e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  21 AIILLS-VALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALA-DLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCG 98
Cdd:cd14977    2 VIMSLSlVIFAVGIIGNLMVLCIVCTNYYMRSVPNILIASLALGdLLLLLLCVPLNAYNLLTKDWLFGDVMCKLVPFIQV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  99 VSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALK----TNMSLCyPKYPS 174
Cdd:cd14977   82 TSLGVTVFSLCALSIDRYRAAVNSMPMQTIGACLSTCVKLAVIWVGSVLLAVPEAVLSTVARESsldnSSLTVC-IMKPS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 175 KEHEAFH------LIFeaLTGFLLPFLAVVASYSDIGRRLQARRFRRSRR----------TGRLVVLIILAFAAFWLPYH 238
Cdd:cd14977  161 TPFAETYpkarswWLF--GCYFCLPLAFTAVCYLLMARTLIRAAKEYTRGtkkhmkqrrqLAKTVLCLVLVFAFCWLPEH 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 966954328 239 VVNLAEAARAlagqASGSGLVGQRLKLARSVLIALAFLSSSVNPVLYAC 287
Cdd:cd14977  239 ISNILRATLY----NEVLIDTRSTLDILDLIGQFLSFFNSCVNPIALYL 283
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
18-153 1.94e-09

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 57.93  E-value: 1.94e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  18 VLLAIILLSVaLAVGLPGNSFVVWSILKRMKKRS----VTALLVLNLALADLAVLLTAPFFLH--FLAQGTWSFGLAGCR 91
Cdd:cd15355    1 VLVTAIYLAL-FVVGTVGNSITLYTLARKKSLQHlqstVHYHLASLALSDLLILLLAMPVELYnfIWVHHPWAFGDAACR 79
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966954328  92 LCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVL 153
Cdd:cd15355   80 GYYFLRDACTYATALNVASLSVERYLAICHPFKAKSLMSRSRTKKFISAIWLASALLAIPML 141
7tmA_P2Y2 cd15373
P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
23-296 2.15e-09

P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y2 belongs to the P2Y receptor family of purinergic G-protein coupled receptors and is implicated to play a role in the control of the cell cycle of endometrial carcinoma cells. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320495 [Multi-domain]  Cd Length: 283  Bit Score: 57.84  E-value: 2.15e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  23 ILLSVALA----VGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGT-WSFGLAGCRLCHYVC 97
Cdd:cd15373    1 ILLPVSYGivfvVGLVLNILALYVFLFRTKPWNASTTYMFNLAISDTLYVLSLPLLVYYYADENdWPFSEALCKIVRFLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  98 GVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALKTNMsLCYPKYPSKEH 177
Cdd:cd15373   81 YTNLYCSILFLLCISVHRFLGVCYPVRSLRWLKVRYARIVSVVVWVIVLACQSPVLYFVTTSDKGGNI-TCHDTSSPELF 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 178 EAFhLIFEALTGFLL---PFLAVVASYSDIGRRLQARRFRRSRRTGR------LVVLIILAFAAFWLPYHVV-NLAEAAR 247
Cdd:cd15373  160 DQF-VVYSSVMLVLLfcvPFVVILVCYALMVRKLLKPSAGTSTNSRSkkksvkMIIIVLAVFILCFLPFHVTrTLYYSFR 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 966954328 248 ALAGQASGSGLVGQRLKLARsvliALAFLSSSVNPVLYACAGGGLLRSA 296
Cdd:cd15373  239 SMDLSCGTLNAINLAYKVTR----PLASANSCLDPILYFLAGQSFRSNL 283
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
23-285 4.26e-09

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 56.72  E-value: 4.26e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  23 ILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPF-FLHFLAQGTWSFGLAGCRLCHYVCGVSM 101
Cdd:cd15199    5 SLLILEFGLGLPGNAIALWTFIFRLKVWKPYAVYLLNLVLADVLLLICLPFkAYFYLNGNRWSLGGGTCKALLFMLSLSR 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 102 YASVLLITAMSLDRSLAVARPfvsqKLRTKAMALRVLAGIWVVSFLLATPvLVYRTVVALKTNMSLCYPKYPSKEHEAFH 181
Cdd:cd15199   85 GVSIAFLTAVALDRYFRVVHP----RGKKNSLSLQAAPYISFLVWLLLVG-LTIPTLLASQPKNFTECNSFSPKDDEDFS 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 182 LIF-EAL--TGFLLPFLAVVasYSDIGRRLQARRFRRSRR-------TGRLVVLIILAFAAFWLPYHVvnlaeaARALAG 251
Cdd:cd15199  160 DTWqEAVffLQFLLPFGLIV--FCTVRIIRRLKKRLRDVGkqpklqrAMALVTSVVVVFGFCFLPCFL------ARVLML 231
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 966954328 252 --QASGSGLVGQRLKLARSVLIALAFLSSSVNPVLY 285
Cdd:cd15199  232 ifQNKESCNALNIAVHTYDVTMCLTYLNSVLDPIVY 267
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
77-242 4.40e-09

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 56.51  E-value: 4.40e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  77 FLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATP-VLVY 155
Cdd:cd15297   60 YTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPaILFW 139
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 156 RTVVALKT-NMSLCYPKYPSKEHEAFHlifEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRrtgrlVVLIILAFAAFW 234
Cdd:cd15297  140 QFIVGGRTvPEGECYIQFFSNAAVTFG---TAIAAFYLPVIIMTVLYWQISRASSREKKVTRT-----ILAILLAFIITW 211

                 ....*...
gi 966954328 235 LPYHVVNL 242
Cdd:cd15297  212 TPYNVMVL 219
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
90-285 4.50e-09

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 56.87  E-value: 4.50e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  90 CRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVV----ALKTNM 165
Cdd:cd14978   77 LPYIYPLANTFQTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVVecenCNNNSY 156
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 166 SLCYPKYPSKEHE---AFHLIFEALTGFLLPFL-------AVVASYSDIGRRLQARRFRRSRRTG---------RLVVLI 226
Cdd:cd14978  157 YYVIPTLLRQNETyllKYYFWLYAIFVVLLPFIlllilniLLIRALRKSKKRRRLLRRRRRLLSRsqrrerrttIMLIAV 236
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 966954328 227 ILAFAAFWLPYHVVNLAEAaralagqASGSGLVGQRLKLARSVLIALAFLSSSVNPVLY 285
Cdd:cd14978  237 VIVFLICNLPAGILNILEA-------IFGESFLSPIYQLLGDISNLLVVLNSAVNFIIY 288
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
72-285 5.93e-09

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 56.37  E-value: 5.93e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  72 PFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKlrTKAMALRVLAGIWVVSFLLAT- 150
Cdd:cd15391   55 PFTFTQIMLGHWVFPAPMCPIVLYVQLVSVTASVLTNTAIGIDRFFAVIFPLRSRH--TKSRTKCIIASIWAISFSLSSv 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 151 PVLVYRTVVALKTN--MSLCYPKYPSKEHEA-FHLIFEALTGFLLPFLAVVASYSDIGR-------------RLQARRFR 214
Cdd:cd15391  133 QLFAGRTQRYGQYSegRVLCGESWPGPDTSRsAYTVFVMLLTYIIPLLILTSTYGYVGFrlwnrtapgnadkGRDDMQIK 212
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 966954328 215 RSRRTGRLVVLIILAFAAFWLPYHVVNLAEAARALAGQASgsglvGQRLKLARSVLIALAFLSSSVNPVLY 285
Cdd:cd15391  213 SKRKVIKMLVFVVLMFGICWLPLHLFNLVQDFSTVFRNMP-----QHTTRLIYGACHWIAMSNSFVNPIIY 278
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
83-285 7.31e-09

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 56.11  E-value: 7.31e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  83 WSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLV-----YRT 157
Cdd:cd15130   71 WAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFtmglqNES 150
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 158 VVALKTNMSLCYPKYPSKEHEAFhLIFEALTGFLLPFLAVvasySDIGRRLQARRFRRSRRTGRLVVLIILAFAAFWLPY 237
Cdd:cd15130  151 DDGTHPGGLVCTPIVDTATLKVV-IQVNTFMSFLFPMLVT----SILNTVIANKLVQALRRGVLVLRAVVIAFVVCWLPY 225
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 966954328 238 HVVNLaeaARALAGQASGSGLVGQRLKLARSVLIALAFLSSSVNPVLY 285
Cdd:cd15130  226 HVRRL---MFCYISDEQWTTFLFDFYHYFYMLTNALFYVSSAINPILY 270
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
21-285 1.38e-08

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 55.21  E-value: 1.38e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  21 AIILLsvalavGLPGNSFVVWSILKRMKKRSVTALLVLNLALA-DLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGV 99
Cdd:cd15399    9 SIILL------GVVGNSLVIYVVIKFKNMRTVTNFFIANLAVAdLMVNTLCLPFTLVYTLLDEWKFGAVLCHLVPYAQAL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 100 SMYASVLLITAMSLDRSLAVARpFVSQKLRTKAMALrVLAGIWVVSFLLATPVLVYR----TVVALKTNMSLCYPKYPSk 175
Cdd:cd15399   83 AVHVSTVTLTVIALDRHRCIVY-HLESKISKKISFL-IIGLTWAASALLASPLAIFReysvIEISPDFKIQACSEKWPN- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 176 EHEAFHLIFEA---LTGFLLPFLAVVASYSDIGRRLQARRFRRSRR---------TGRLVVLIILAFAAFWLPYHVVNLA 243
Cdd:cd15399  160 GTLNDGTIYSVsmlLIQYVLPLAIISYAYIRIWTKLKNHVSPGGGNdhyhqrrrkTTKMLVCVVVVFAVSWLPFHAFQLA 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 966954328 244 eaaralagqasgSGLVGQRLKLARSVLI-----ALAFLSSSVNPVLY 285
Cdd:cd15399  240 ------------SDIDSKVLDLKEYKLIytifhVIAMCSTFANPLLY 274
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
18-285 1.56e-08

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 55.06  E-value: 1.56e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  18 VLLAIILLSVaLAVGLPGNSFVVWSILKRMKKRS-VTALLVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYV 96
Cdd:cd15213    1 ITLAILMILM-IFVGFLGNSIVCLIVYQKPAMRSaINLLLANLAFSDIMLSLVCMPFAAVTIITGRWIFGDIFCRISAML 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  97 CGVSMYASVLLITAMSLDRSLAVARpfvSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALKTNMSLCYPKYPSKE 176
Cdd:cd15213   80 YWFFVLEGVAILLIISVDRYLIIVQ---RQDKLNPHRAKILIAVSWVLSFCVSFPPLVGWGKYEFPPRAPQCVLGYTESP 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 177 HEAFHLIFEALTGFLLPFLAVVASYSDIgrrlQARRFRRSRRTGRLVVLIILAFAAFWLPYHVVNLAeaarALAGQASGS 256
Cdd:cd15213  157 ADRIYVVLLLVAVFFIPFLIMLYSYFCI----LNTVRSFKTRAFTTILILFIGFSVCWLPYTVYSLL----SVFSRYSSS 228
                        250       260
                 ....*....|....*....|....*....
gi 966954328 257 GLVgqrlklARSVLIALAFLSSSVNPVLY 285
Cdd:cd15213  229 FYV------ISTCLLWLSYLKSAFNPVIY 251
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
21-285 1.57e-08

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 55.13  E-value: 1.57e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  21 AIILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGTW-SFGLAGCRLCHYVCGV 99
Cdd:cd14964    1 TTIILSLLTCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDLLASLVVLVLFFLLGLTEAsSRPQALCYLIYLLWYG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 100 SMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALKTN-MSLCYPKYPSKEHE 178
Cdd:cd14964   81 ANLASIWTTLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWGVSLLLSIPPLVGKGAIPRYNTlTGSCYLICTTIYLT 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 179 AFHLIFealtGFLLPFLAVVASYSDI----------GRRLQARRFRRSRRTGRLVVLIILAFAAFWLPYHVVNLaeaara 248
Cdd:cd14964  161 WGFLLV----SFLLPLVAFLVIFSRIvlrlrrrvraIRSAASLNTDKNLKATKSLLILVITFLLCWLPFSIVFI------ 230
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 966954328 249 laGQASGSGlvGQRLKLARSVLIALAFLSSSVNPVLY 285
Cdd:cd14964  231 --LHALVAA--GQGLNLLSILANLLAVLASTLNPFIY 263
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
23-286 1.81e-08

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 54.74  E-value: 1.81e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  23 ILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFL--HFLAQgtWSFGLAGCRLCHYVCGVS 100
Cdd:cd15087    5 VIYSVICAVGLTGNTAVIYVILRAPKMKTVTNVFILNLAIADDLFTLVLPINIaeHLLQQ--WPFGELLCKLILSIDHYN 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 101 MYASVLLITAMSLDRSLAVARPFVSQKL--RTKAMALRVLAGIWVVSFLLATPVLVYRTVVALKTNMSLCYPKYPSKEHE 178
Cdd:cd15087   83 IFSSIYFLTVMSVDRYLVVLATVRSRRMpyRTYRAAKIVSLCVWLLVTIIVLPFTVFAGVYSNELGRKSCVLSFPSPESL 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 179 AFHL--IFEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRT-------GRLVVLIILAFAAF-WLPYHVVNLAeaarA 248
Cdd:cd15087  163 WFKAsrIYTLVLGFAIPVSTICILYTMMLYKLRNMRLNSNAKAldkakkkVTLMVLVVLAVCLFcWTPFHLSTVV----A 238
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 966954328 249 LAGQASGSGLVgqrlkLARSVLI-ALAFLSSSVNPVLYA 286
Cdd:cd15087  239 LTTDLPQTPLV-----IGISYFItSLSYANSCLNPFLYA 272
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
83-285 4.17e-08

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 53.85  E-value: 4.17e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  83 WSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSqkLRTKAMALRVLAGIWVVSFLLATP-VLVYRTVV-A 160
Cdd:cd15382   67 WLAGDFLCRLMLFFRAFGLYLSSFVLVCISLDRYFAILKPLRL--SDARRRGRIMLAVAWVISFLCSIPqSFIFHVEShP 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 161 LKTNMSLC--YPKYPSKEHEAFHLIFEALTGFLLPFLAVVASYSDI-----------GRRLQARRFRRSRRTGR------ 221
Cdd:cd15382  145 CVTWFSQCvtFNFFPSHDHELAYNIFNMITMYALPLIIIVFCYSLIlceisrkskekKEDVSEKSSSVRLRRSSvgller 224
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966954328 222 -------LVVLIILAFAAFWLPYHVVNL-----AEAAralagqasgsGLVGQRLklaRSVLIALAFLSSSVNPVLY 285
Cdd:cd15382  225 arsrtlkMTIVIVLVFIICWTPYFIMSLwywfdRESA----------SKVDPRI---QKGLFLFAVSNSCMNPIVY 287
7tmA_P2Y10 cd15153
P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled ...
32-194 5.25e-08

P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y10 receptor is a G-protein coupled receptor that is activated by both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA). Phylogenetic analysis of the class A GPCRs shows that P2Y10 is grouped into the cluster comprising nucleotide and lipid receptors. Although the mouse P2Y10 was found to be expressed in brain, lung, reproductive organs, and skeletal muscle, the physiological function of this receptor is not yet known. S1P and LPA are bioactive lipid molecules that induce a variety of cellular responses through G proteins: adhesion, invasion, cell migration and proliferation, among many others.


Pssm-ID: 320281 [Multi-domain]  Cd Length: 283  Bit Score: 53.64  E-value: 5.25e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  32 GLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAM 111
Cdd:cd15153   14 GLLANSAALWVLCRFISKKNKAIIFMINLAVADLAHVLSLPLRIHYYIQHTWPFGRFLCLLCFYLKYLNMYASICFLTCI 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 112 SLDRSLAVARPFVSQKLRTKaMALRVLAGIWVVSFLLATPVLVYRTvVALKTNMSLCYPKYPSKEHEAFHLI----FEAL 187
Cdd:cd15153   94 SIQRCFFLLHPFKARDWKRR-YDVGISAAVWIVVGLACLPFPLLRS-KSLSNNNRSCFADLGMKKLNFGAAIammtVAEL 171

                 ....*..
gi 966954328 188 TGFLLPF 194
Cdd:cd15153  172 FGFVIPL 178
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
72-286 5.60e-08

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 53.09  E-value: 5.60e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  72 PFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLL-AT 150
Cdd:cd15049   55 NLYTVYLVMGYWPLGPLLCDLWLALDYVASNASVMNLLLISFDRYFSVTRPLTYRAKRTPKRAILMIALAWVISFVLwAP 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 151 PVLVYRTVVALKT-NMSLCYPKYPSkehEAFHLIFEALTGFLLPFLAVVASYSDIgrrlqARRFRRSRRTGRLVVLIILA 229
Cdd:cd15049  135 AILGWQYFVGERTvPDGQCYIQFLD---DPAITFGTAIAAFYLPVLVMTILYWRI-----YRETARERKAARTLSAILLA 206
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 966954328 230 FAAFWLPYHVVNLAEaaralagqASGSGLVGQRLklaRSVLIALAFLSSSVNPVLYA 286
Cdd:cd15049  207 FIITWTPYNILVLVS--------TFCAKCIPDTL---WSFGYWLCYINSTINPFCYA 252
7tmA_NPY5R cd15398
neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G ...
31-285 7.09e-08

neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320520 [Multi-domain]  Cd Length: 273  Bit Score: 52.85  E-value: 7.09e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  31 VGLPGNSFVVWSILKRMKKRS-VTALLVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLIT 109
Cdd:cd15398   13 LGFLGNLLILTALTKKWKQKTiINFLIGNLAFSDILVVLFCSPFTLTCVLLDQWIFGEVMCHIVPFLQCVSVMVSTLMLM 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 110 AMSLDRSLAVARPfVSQKLRTKAMALrVLAGIWVVSFLLATPVLVYRTVVALK--------TNMSLCYPKYPSKEHEAFH 181
Cdd:cd15398   93 SIAIVRYHMIKHP-LSNHLTANHGYF-LLGTVWTLGFTICSPLPVFHKIVDLSetfnleslKNKYLCIESWPSDSYRIAF 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 182 LIFEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRrtgrlVVLIILAFAAFWLPYHVVNLAEaaralagQASGSGLVGQ 261
Cdd:cd15398  171 TISLLFVQYILPLVCLTVSHTSVCRSVKRSRSVFYR-----LTIVILAFAVSWMPLHLFHLVT-------DFNANLISNR 238
                        250       260
                 ....*....|....*....|....
gi 966954328 262 RLKLARSVLIALAFLSSSVNPVLY 285
Cdd:cd15398  239 HFKLVYCICHLLGMLSCCLNPILY 262
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
21-286 8.75e-08

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 52.65  E-value: 8.75e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  21 AIILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALA-DLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGV 99
Cdd:cd15210    3 AAVWGIVFMVVGVPGNLLTVLALLRSKKLRTRTNAFIINLSISdLLFCAFNLPLAASTFLHQAWIHGETLCRVFPLLRYG 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 100 SMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSF-LLATPVLVYRTVVALKTNMSLCYPKYPSKEHE 178
Cdd:cd15210   83 LVAVSLLTLVLITLNRYILIAHPSLYPRIYTRRGLALMIAGTWIFSFgSFLPLWLGIWGRFGLDPKVCSCSILRDKKGRS 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 179 AFHLIFeaLTGFLLPFLAVVASYSdigrrlqarrFRRSRRTGRLVVLIILAFAAFWLPYHVVNLAEAARAlagqasgsgl 258
Cdd:cd15210  163 PKTFLF--VFGFVLPCLVIIICYA----------RREDRRLTRMMLVIFLCFLVCYLPITLVNVFDDEVA---------- 220
                        250       260
                 ....*....|....*....|....*...
gi 966954328 259 vGQRLKLARSVLIalaFLSSSVNPVLYA 286
Cdd:cd15210  221 -PPVLHIIAYVLI---WLSSCINPIIYV 244
PHA02834 PHA02834
chemokine receptor-like protein; Provisional
72-294 9.77e-08

chemokine receptor-like protein; Provisional


Pssm-ID: 165177  Cd Length: 323  Bit Score: 52.98  E-value: 9.77e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  72 PFFLHFlAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARpfvSQKLRTKAMALRVL--AGIWVVSFLLA 149
Cdd:PHA02834  81 PFIIHN-DLNEWIFGEFMCKLVLGVYFVGFFSNMFFVTLISIDRYILVVN---ATKIKNKSISLSVLlsVAAWVCSVILS 156
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 150 TPVLVYRTVVALKTNMSLCYPKYPSKEHEAFHLIFEA-LTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIIL 228
Cdd:PHA02834 157 MPAMVLYYVDNTDNLKQCIFNDYHENFSWSAFFNFEInIFGIVIPLIILIYCYSKILYTLKNCKNKNKTRSIKIILTVVT 236
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966954328 229 AFAAFWLPYHVVNLAEAARALaGQASGSGLVGQRLKLARSVLIALAFLSSSVNPVLYACAGGGLLR 294
Cdd:PHA02834 237 FTVVFWVPFNIVLFINSLQSV-GLIDIGCYHFKKIVYSIDIAELISFVHCCVNPIIYAFVGKNFKK 301
7tmA_Mrgpr cd14973
mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G ...
17-289 9.96e-08

mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined. Also included in this family is Mas-related G-protein coupled receptor 1-like (MAS1L) which is only found in primates. The angiotensin-II metabolite angiotensin is an endogenous ligand for MAS1L.


Pssm-ID: 320104 [Multi-domain]  Cd Length: 272  Bit Score: 52.64  E-value: 9.96e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  17 IVLLAIILLSValaVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGTWsFGLAGCRLCHYV 96
Cdd:cd14973    2 VIFSLTVLLSL---CGLVGNGLVLWLLGFRIKRNPFSVYILNLAAADFLFLSCQAIQSLEDLLGGSL-PGFALCRLLATL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  97 CGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALKTNMSLCypkypske 176
Cdd:cd14973   78 MFFSYTVGLSLLAAISTERCLSVLFPIWYRCHRPKHLSAVVCALLWALSLLLSVLESYFCGFLFWKFNESAC-------- 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 177 heaFHLIFEALTGFLLPF-LAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILAFAAFWLPYHVVNLAEAARAlagqasg 255
Cdd:cd14973  150 ---RTFNFLSALLFLLLFlVMCVSSLTLLIRVQCSSQRRPPTRLYVVILLTVLVFLLCGLPLGIYWFLLLWFS------- 219
                        250       260       270
                 ....*....|....*....|....*....|....
gi 966954328 256 sglvGQRLKLARSVLIALAFLSSSVNPVLYACAG 289
Cdd:cd14973  220 ----NYLFHTFHPISDLLSCVNSSANPIIYFFVG 249
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
72-286 1.06e-07

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 52.52  E-value: 1.06e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  72 PFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATP 151
Cdd:cd15301   55 PLFTVYTALGYWPLGYEVCDTWLAIDYLASNASVLNLLIISFDRYFSVTRPLTYRARRTTKKAAVMIASAWIISLLLWPP 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 152 VLVYRTVVALKTNMSL--CYPKYPSKEHeaFHLIFEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILA 229
Cdd:cd15301  135 WIYSWPYIEGKRTVPAgtCYIQFLETNP--YVTFGTALAAFYVPVTIMCILYWRIWRETKKRQKKQESKAAKTLSAILLA 212
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 966954328 230 FAAFWLPYHVVNLAEAAralagqASGSGLVGQRLklaRSVLIALAFLSSSVNPVLYA 286
Cdd:cd15301  213 FIVTWTPYNVLVLIKAF------FPCSDTIPTEL---WDFSYYLCYINSTINPLCYA 260
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
77-242 1.33e-07

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 51.94  E-value: 1.33e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  77 FLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATP-VLVY 155
Cdd:cd15298   60 YIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPaILFW 139
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 156 RTVVALKTNMS-LCYPKYPSKEHEAFHlifEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRrtgrlVVLIILAFAAFW 234
Cdd:cd15298  140 QFVVGKRTVPDnQCFIQFLSNPAVTFG---TAIAAFYLPVVIMTVLYIHISLASARERKVTRT-----IFAILLAFILTW 211

                 ....*...
gi 966954328 235 LPYHVVNL 242
Cdd:cd15298  212 TPYNVMVL 219
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
77-242 1.36e-07

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 52.28  E-value: 1.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  77 FLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATP-VLVY 155
Cdd:cd17790   60 YILMGHWALGTVACDLWLALDYVASNASVMNLLIISFDRYFSITRPLTYRAKRTPRRAAIMIGLAWLISFVLWAPaILFW 139
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 156 RTVVALKTNMSL-CYPKYPSKEHEAFHlifEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGrlvvlIILAFAAFW 234
Cdd:cd17790  140 QYLVGERTVLAGqCYIQFLSQPIITFG---TAIAAFYLPVTIMIILYWRIYRETIKEKKAARTLSA-----ILLAFILTW 211

                 ....*...
gi 966954328 235 LPYHVVNL 242
Cdd:cd17790  212 TPYNIMVL 219
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
82-287 1.40e-07

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 52.29  E-value: 1.40e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  82 TWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVL---VYRTV 158
Cdd:cd14997   66 PWLLGEFMCKLVPFVELTVAHASVLTILAISFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTSSPVLfitEFKEE 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 159 VALKTNMSLCYPKYPSKEHEAFHLIFEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGR--------------LVV 224
Cdd:cd14997  146 DFNDGTPVAVCRTPADTFWKVAYILSTIVVFFVVPLAILSGLYSVICRRLVGHPALESRRADAanrhtlrsrrqvvyMLI 225
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966954328 225 LIILAFAAFWLPYHVVNL-AEAARALAGQASGSGLVGQRLKLARSvliaLAFLSSSVNPVLYAC 287
Cdd:cd14997  226 TVVVLFFVCLLPFRVVTLwIIFAPDEDLQALGLEGYLNLLVFCRV----MVYLNSALNPILYNL 285
7tmA_GPR150 cd15198
G protein-coupled receptor 150, member of the class A family of seven-transmembrane G ...
22-285 1.74e-07

G protein-coupled receptor 150, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors. Its endogenous ligand is not known. These receptors share a significant amino acid sequence similarity, suggesting that they have a common evolutionary origin.


Pssm-ID: 320326 [Multi-domain]  Cd Length: 299  Bit Score: 52.12  E-value: 1.74e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  22 IILLSVALAVGLPGNSFV-VWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHF-LAQGTWSFGLAGCRLCHYVCGV 99
Cdd:cd15198    4 LIFLGVILVAGVAGNTTVlCWLCGGRRRKSRMNFLLLQLALADLLVIGGTALSQIIWeLLGDRWMAGDVACRLLKLLQAS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 100 SMYASVLLITAMSLDRSLAVARPFvSQKLRTKAMAlrvlAGIWVVSFLLATPVLVYRTVVALKT------NMSLCYPKYP 173
Cdd:cd15198   84 ARGASANLVVLLALDRHQAIRAPL-GQPLRAWKLA----ALGWLLALLLALPQAYVFRVDFPDDpasawpGHTLCRGIFA 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 174 S--KEHEAFHLIFEALTGFLLPF----------LAVVASYSDIGRRLQARRFRRSRRTGR----------------LVVL 225
Cdd:cd15198  159 PlpRWHLQVYATYEAVVGFVAPVvilgvcygrlLLKWWERANQAPGAKKPWKKPSKSHLRatapsalprakvktlkMTLV 238
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 226 IILAFAAFWLPYHVVNLAeaaralagqASGSGLVGQRLKLArSVLIALAFLSSSVNPVLY 285
Cdd:cd15198  239 IALLFVGCSLPYFIAELA---------AAFGSGDWEPEKVA-AALGVMAVANSATNPFVF 288
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
83-242 2.14e-07

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 51.82  E-value: 2.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  83 WSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVAL- 161
Cdd:cd15124   66 WLFGRVGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMDIQASNALMKICLKAALIWILSMLLAIPEAVFSDLHPFy 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 162 --KTNMSL--CYPkYPSKE--HEAFHLIFEALTGFLLPFLAVVASYSDI--------------GRRLQARRFRRSRRTGR 221
Cdd:cd15124  146 dkSTNKTFvsCAP-YPHSNelHPKIHSMASFLIFYVIPLSIISVYYYFIaknlirsaynlpveGNVHVRRQIESRKRLAK 224
                        170       180
                 ....*....|....*....|.
gi 966954328 222 LVVLIILAFAAFWLPYHVVNL 242
Cdd:cd15124  225 TVLVFVGLFAFCWLPNHIIYL 245
7tmA_GPR34-like cd15148
putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G ...
22-205 2.97e-07

putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 34 of unknown function. Orphan GPR34 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320276 [Multi-domain]  Cd Length: 282  Bit Score: 51.23  E-value: 2.97e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  22 IILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPF-FLHFLAQGTWSFGLAGCRLCHYVCGVS 100
Cdd:cd15148    4 AVFYSLIFLFGLVGNLLALWVFLFIHRKRNSVRIFLINVAIADLLLIICLPFrILYHVNNNQWTLGPLLCKVVGNLFYMN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 101 MYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLvyrtVVALKTNMS-LCYpKYPSKEHEA 179
Cdd:cd15148   84 MYISIILLGFISLDRYLKINRSSRRQKFLTRKWSIVACGVLWAVALVGFVPMI----VLTEKNEEStKCF-QYKDRKNAK 158
                        170       180
                 ....*....|....*....|....*...
gi 966954328 180 FHLIFEAL--TGFLLPFLAVVASYSDIG 205
Cdd:cd15148  159 GKAIFNFLivAMFWLVFLLLILSYGKIA 186
7tmA_P2Y-like cd15922
P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G ...
23-285 3.16e-07

P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y-like proteins are an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320588 [Multi-domain]  Cd Length: 284  Bit Score: 51.25  E-value: 3.16e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  23 ILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQG-TWSFGLAGCRLCHYVCGVSM 101
Cdd:cd15922    5 VFLSLVFLGGFLLNSFSLWIFWFRIKQWSSGTILQFNLALSDAIITPAAPLLIAYFSLGsHWPFGQFLCQLKVFLLSTHM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 102 YASVLLITAMSLDRSLAVARpFVSQKLRTKAMALRVL-AGIWVVSFLLATPVLVYrtvvaLKT----NMSLCYPKYPSKE 176
Cdd:cd15922   85 YGSIYFLMLISIHRYVTVVH-YNWKSLWKKKSFMKKLcLGVWLLLFVQGLPFFFV-----LKTsvidGKTKCLSIHQSEL 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 177 HEAFHL--IFEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGR------LVVLIILAFAAFWLPYHVVNLAEAARA 248
Cdd:cd15922  159 SLLYFVwnFVLLILGFLLPFGVSLTCYALLGASIAKMNSNNARGRAMkakslqMIGISLVIFIICFVPLHVTRTVGVVVK 238
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 966954328 249 LAGQASGSGLvgQRLKLARSVLIALAFLSSSVNPVLY 285
Cdd:cd15922  239 LFYPESCTLL--HKVEVAYYISWVLTGVNCCLDPLLY 273
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
88-285 3.78e-07

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 51.05  E-value: 3.78e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  88 AGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLrTKAMALRVLAGIWVVSFLLA-TPVLVYRTVVALKTNMS 166
Cdd:cd15137   78 WLCTFAGFLATLSSEVSVLILTLITLDRFICIVFPFSGRRL-GLRRAIIVLACIWLIGLLLAvLPLLPWDYFGNFYGRSG 156
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 167 LCYP------KYPSKEHEAFHLIFEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLV---VLIILAFAAFWLPY 237
Cdd:cd15137  157 VCLPlhitdeRPAGWEYSVFVFLGLNFLAFVFILLSYIAMFISIRRTRKAAASRKSKRDMAVAkrfFLIVLTDFLCWIPI 236
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 966954328 238 HVVNLAeaarALAGqASGSGLVgqrlkLARSVLIALAfLSSSVNPVLY 285
Cdd:cd15137  237 IVIGIL----ALSG-VPIPGEV-----YAWVAVFVLP-INSALNPILY 273
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
83-285 4.63e-07

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 50.63  E-value: 4.63e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  83 WSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVY------- 155
Cdd:cd15356   71 WVFGDLVCRGYYFVRDICSYATVLNIASLSAERYLAICQPLRAKRLLSKRRTKWLLALIWASSLGFALPMAFImgqkyel 150
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 156 RTVVALKTNMSLCYPKYPSKEHEAFHLIFEALTGFLLPfLAVVASYSdiGRRLQARRFRRSRRTGRLVVLIILAFAAFWL 235
Cdd:cd15356  151 ETADGEPEPSSRVCTVLVSRATLKVFIQVNAFVSFVLP-LALIAFLN--GVTVSHLRIQSLQHSVQVLRAIVIAYVICWL 227
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 966954328 236 PYHvvnlaeAARALAGQASGSGLVGQRLKLARSVLI---ALAFLSSSVNPVLY 285
Cdd:cd15356  228 PYH------ARRLMFCYVPDDAWTDSLYNFYHYFYMltnTLFYVSSAVNPLLY 274
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
72-285 5.75e-07

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 50.33  E-value: 5.75e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  72 PFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATP 151
Cdd:cd15334   55 PFSIMYIVKETWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMIAVVWIISIFISMP 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 152 VLVYRTVVALKTNMSLCypkypsKEHEAFHLIFEALTGFLLPFLAVVASYSDIgrrlqARRFRRSRRTGRLVVLIILAFA 231
Cdd:cd15334  135 PLFWRHQTTSREDECII------KHDHIVFTIYSTFGAFYIPLALILILYYKI-----YRAATRERKAATTLGLILGAFV 203
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 966954328 232 AFWLPYHV----VNLAEAARALAGQAsgsglvgqrlklarSVLIALAFLSSSVNPVLY 285
Cdd:cd15334  204 ICWLPFFVkeviVNTCDSCYISEEMS--------------NFLTWLGYINSLINPLIY 247
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
83-289 5.88e-07

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 50.78  E-value: 5.88e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  83 WSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATP---VLVYRTVV 159
Cdd:PHA02638 161 WIFGDFMCKVISASYYIGFFSNMFLITLMSIDRYFAILYPISFQKYRTFNIGIILCIISWILSLIITSPayfIFEASNII 240
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 160 ALKTNMSLCYPKYPS---KEHEAFHLIFEA--------LTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIIL 228
Cdd:PHA02638 241 FSAQDSNETISNYQCtliEDNEKNNISFLGrilqfeinILGMFIPIIIFAFCYIKIILKLKQLKKSKKTKSIIIVSIIII 320
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966954328 229 AFAAFWLPYHVVNLAEAARALAGQAS-GSGLVGQRLKLARSVLI--ALAFLSSSVNPVLYACAG 289
Cdd:PHA02638 321 CSLICWIPLNIVILFATMYSFKGFNSiISEHICGFIKLGYAMMLaeAISLTHCCINPLIYTLIG 384
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
19-285 5.89e-07

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 50.12  E-value: 5.89e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  19 LLAIILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALA-DLAVLLTAPFFLHFLAQGTWSFGLAGCRL---CH 94
Cdd:cd15060    1 VVTTILLSVIIAFTIVGNILVILSVFTYRPLRIVQNFFIVSLAVAdLAVAIFVLPLNVAYFLLGKWLFGIHLCQMwltCD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  95 YVCGVsmyASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLV-YRTVVALKTNMSLCYPKyp 173
Cdd:cd15060   81 ILCCT---ASILNLCAIALDRYWAIHDPINYAQKRTLKRVLLMIVVVWALSALISVPPLIgWNDWPENFTETTPCTLT-- 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 174 skeHEAFHLIFEALTGFLLPFLAVVASYSDIgrrlqARRFRRSRRTGRLVVLIILAFAAFWLPYHvvnLAEAARALAGQA 253
Cdd:cd15060  156 ---EEKGYVIYSSSGSFFIPLLIMTIVYVKI-----FIATSKERRAARTLGIIMGVFVVCWLPFF---LMYVILPFCETC 224
                        250       260       270
                 ....*....|....*....|....*....|..
gi 966954328 254 SGSGLVgqrlklaRSVLIALAFLSSSVNPVLY 285
Cdd:cd15060  225 SPSAKV-------VNFITWLGYVNSALNPVIY 249
7tmA_GPR87 cd15969
G protein-coupled receptor 87, member of the class A family of seven-transmembrane G ...
81-168 7.27e-07

G protein-coupled receptor 87, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR87 acts as one of multiple receptors for lysophosphatidic acid (LPA). This orphan receptor has been shown to be over-expressed in several malignant tumors including lung squamous cell carcinoma and regulated by p53. GPR87 is phylogenetically closely related to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase.


Pssm-ID: 320635 [Multi-domain]  Cd Length: 283  Bit Score: 50.17  E-value: 7.27e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  81 GTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVA 160
Cdd:cd15969   63 GPWNFNFFLCRYTSVLFYASMYTSIVFLGLISLDRYLKVVKPFGDSRMYSITFTKVLSACVWLIMAFLSLPNIILTNGQP 142

                 ....*...
gi 966954328 161 LKTNMSLC 168
Cdd:cd15969  143 TEDNIHDC 150
7tmA_PAR2 cd15370
protease-activated receptor 2, member of the class A family of seven-transmembrane G ...
23-201 7.45e-07

protease-activated receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341349 [Multi-domain]  Cd Length: 280  Bit Score: 49.80  E-value: 7.45e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  23 ILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGT-WSFGLAGCRLCHYVCGVSM 101
Cdd:cd15370    5 IVYIIVFVVGLPSNAMALWVFLFRTKKKHPAVIYMANLALADLLFVIWFPLKIAYHINGNnWIYGEALCKVLIGFFYGNM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 102 YASVLLITAMSLDRSLAVARPFVSQKLRTKaMALRVLAGIWVVSFLLATPVLVY-RTVVALKTNMSLCYPKYPSKE--HE 178
Cdd:cd15370   85 YCSILFMTCLSVQRYWVIVNPMSHSRKKAN-IAIGISLAIWLLILLVTIPLYLVkQTVFIPALDITTCHDVLPEQLlvGD 163
                        170       180
                 ....*....|....*....|....
gi 966954328 179 AF-HLIFEALTGFLLPFLAVVASY 201
Cdd:cd15370  164 MFnYFLSLAIGVFLFPAFLTAVAY 187
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
21-285 7.45e-07

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 50.08  E-value: 7.45e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  21 AIILLSVALAVGLPGNSFVVWSIL--KRMKKRSVTALLVLNLALADLAVLLTAP-FFLHFLAQGTWSFGLAGCRLCHYVC 97
Cdd:cd14995    3 ATFLVLLICGVGIVGNIMVVLVVLrtRHMRTPTNCYLVSLAVADLMVLVAAGLPnEIESLLGPDSWIYGYAGCLLITYLQ 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  98 GVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATP---VLVYRTVVALKTNMSLCYPKYPS 174
Cdd:cd14995   83 YLGINASSLSITAFTIERYIAICHPMKAQFICTVSRAKKIICFVWIFTSLYCSPwlfLLDLSIKHYGDDIVVRCGYKVSR 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 175 KEHEAFHLIfEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLiilaFAAFWLPYH---VVNlaeaaralaG 251
Cdd:cd14995  163 HYYLPIYLA-DFVLFYVIPLLLAIVLYGLIGRILFSSRKQVTKMLAVVVVL----FALLWMPYRtlvVYN---------S 228
                        250       260       270
                 ....*....|....*....|....*....|....
gi 966954328 252 QASGSGLVGQRLKLARsvliALAFLSSSVNPVLY 285
Cdd:cd14995  229 FASPPYLDLWFLLFCR----TCIYLNSAINPILY 258
7tmA_GPR174-like cd15152
putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G ...
23-198 7.57e-07

putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR174 has been recently identified as a lysophosphatidylserine receptor that enhances intracellular cAMP formation by coupling to a G(s) protein. GPR174 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320280 [Multi-domain]  Cd Length: 282  Bit Score: 50.11  E-value: 7.57e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  23 ILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVSMY 102
Cdd:cd15152    5 VTYTVILIPGLIGNVLALWVFYAYVKETKRAVIFMINLAIADLLQVLSLPLRIFYYLNKSWPFGKFLCMFCFYLKYVNMY 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 103 ASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGiWVVSFLLATPVLVYRTvvALKTNMSLCYPKYP----SKEHE 178
Cdd:cd15152   85 ASIYFLVCISVRRCLYLIYPFRYNDCKRKCDVYISIAG-WLVVCVGCLPFPLLRQ--SQDTNPTCCFADLPlrnvGLTTS 161
                        170       180
                 ....*....|....*....|
gi 966954328 179 AFHLIFEALTGFLLPFLAVV 198
Cdd:cd15152  162 VIMLTIAELTGFVTPLLIVL 181
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
76-282 7.61e-07

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 49.92  E-value: 7.61e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  76 HFLAQgTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFvsqKLRTKAMALR--VLAG-IWVVSFLLATPV 152
Cdd:cd15123   60 RYIAD-TWLFGRIGCKLLSFIQLTSVGVSVFTLTVLSADRYRAIVKPL---ELQTSDAVLKtcCKAGcVWIVSMLFAIPE 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 153 LVYRTVVALK-----TNMSLCYPkYPSKEH--EAFHLIFEALTGFLLPFLAVVASYSDIGRRLQARRFRRSR-------- 217
Cdd:cd15123  136 AVFSDLYSFRdpeknTTFEACAP-YPVSEKilQEIHSLLCFLVFYIIPLSIISVYYFLIARTLYKSTFNMPAeehshark 214
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966954328 218 ------RTGRLVVLIILAFAAFWLPYHVVNLAEAAralagqASGSGLVGQRLKLARSVLI-ALAFLSSSVNP 282
Cdd:cd15123  215 qiesrkRVAKTVLVLVALFAFCWLPNHILYLYRSF------TYHTSVDSSAFHLIATIFSrVLAFSNSCVNP 280
7tmA_GPR35-like cd15164
G protein-coupled receptor 35 and similar proteins, member of the class A family of ...
19-198 1.68e-06

G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. Several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast. GPR35 couples to G(13) and G(i/o) proteins.


Pssm-ID: 320292 [Multi-domain]  Cd Length: 272  Bit Score: 48.80  E-value: 1.68e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  19 LLAIILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGTWSFGLagCRLCHYVCG 98
Cdd:cd15164    1 LIQLIIYIPILFFGLLFNVLALWVFCCKMKKWTETRVYMINLAVADCCLLFSLPFVLYFLKHSWPDDEL--CLVLQSIYF 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  99 VSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVsfllatpVLVYRTVVALKT--NMSLCYPKyPSKE 176
Cdd:cd15164   79 INRYMSIYIITAIAVDRYIAIKYPLKAKSLRSPRKAALTCGLLWVL-------VIISVSLRLAWEeqEENFCFGK-TSTR 150
                        170       180
                 ....*....|....*....|..
gi 966954328 177 HEAFHLIFeALTGFLLPFLAVV 198
Cdd:cd15164  151 PSKRTLIF-SLLGFFIPLIILS 171
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
72-286 1.95e-06

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 48.84  E-value: 1.95e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  72 PFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATP 151
Cdd:cd15048   55 PFYIPYTLTGKWPFGKVFCKAWLVVDYTLCTASALTIVLISLDRYLSVTKAVKYRAKQTKRRTVLLMALVWILAFLLYGP 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 152 VLVYRTVVA----LKTNmsLCYPKYPSkeheafHLIFEALTG---FLLPFLAVVASYSDI----------------GRRL 208
Cdd:cd15048  135 AIIGWDLWTgysiVPTG--DCEVEFFD------HFYFTFITSvleFFIPFISVSFFNLLIylnirkrsrrrplrsvPILP 206
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 209 QARRFRRSRRTGRLVVL------------IILAFAAFWLPYHVVNLAEAAralagqASGSGLVgqrlKLARSVLIALAFL 276
Cdd:cd15048  207 ASQNPSRARSQREQVKLrrdrkaakslaiLVLVFLICWAPYTILTIIRSF------CSGSCVD----SYLYEFTFWLLWT 276
                        250
                 ....*....|
gi 966954328 277 SSSVNPVLYA 286
Cdd:cd15048  277 NSAINPFLYA 286
7tmA_GPER1 cd14989
G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G ...
99-289 1.98e-06

G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled estrogen receptor 1 (GPER1), also known as the G-protein coupled receptor 30 (GPR30), is a high affinity receptor for estrogen. This receptor is a member of the class A of seven-transmembrane GPCRs. Estrogen binding results in intracellular calcium mobilization and synthesis of phosphatidylinositol (3,4,5)-trisphosphate in the nucleus. GPR30 plays an important role in development of tamoxifen resistance in breast cancer cells. The distribution of GPR30 is well established in the rodent, with high expression observed in the hypothalamus, pituitary gland, adrenal medulla, kidney medulla and developing follicles of the ovary. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320120 [Multi-domain]  Cd Length: 276  Bit Score: 48.67  E-value: 1.98e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  99 VSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLAtpvLVYRTVVALK--TNMSLCYPKYPSKE 176
Cdd:cd14989   80 INMYSSIFFLTWMSFDRYIALAKVMKSSPLRTMQHARLSCGLIWMASISAT---LLPFTAVQAQhtGEVHFCFADVREIQ 156
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 177 HeafhliFEALTGFLLPFLAVVASYSDIGRRLQARRFRRSR-----RTGRLVVLIILAFAAFWLPYhvvNLAEAARALAG 251
Cdd:cd14989  157 W------LEVTLGFIIPFSIIGLCYSLIVRVLVRAQKHRRLrprrqKALRMILVVVLVFFICWLPE---NVFISIQLLQG 227
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 966954328 252 QASGSGLVGQRLK----LARSVLIALAFLSSSVNPVLYACAG 289
Cdd:cd14989  228 TQEPSESYDESFRhnhpLTGHIVNLAAFSNSCLNPLIYSFLG 269
7tmA_PAFR cd15147
platelet-activating factor receptor, member of the class A family of seven-transmembrane G ...
23-285 2.13e-06

platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The platelet-activating factor receptor is a G(q/11)-protein coupled receptor, which is linked to p38 MAPK and PI3K signaling pathways. PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) which is synthesized by cells especially involved in host defense such as platelets, macrophages, neutrophils, and monocytes. PAF is well-known for its ability to induce platelet aggregation and anaphylaxis, and also plays important roles in allergy, asthma, and inflammatory responses, among many others.


Pssm-ID: 320275 [Multi-domain]  Cd Length: 291  Bit Score: 48.59  E-value: 2.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  23 ILLSVALAVGLPGNSFVVWsILKRM---KKRSVTALLVLNLALADLAVLLTAPFFL-HFLAQGTWSFGLAGCRLCHYVCG 98
Cdd:cd15147    5 IVYSIIFVLGLIANCYVLW-VFARLypsKKLNEIKIFMVNLTIADLLFLITLPFWIvYYHNEGNWILPKFLCNVAGCLFF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  99 VSMYASVLLITAMSLDRSLAVARPF--VSQKLRTKAMALRVLagIWVVSFLLATPVLVY---RTVVALKTNMSLCYPKYP 173
Cdd:cd15147   84 INTYCSVAFLGVISYNRYQAVTRPIktAQSTTRKRGIIISVA--IWVIIVASASYFLFMdstNTVKIDSGNFTRCFEGYE 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 174 SKEHEAFHLI-FEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGR------LVVLIILAFAAFWLPYHVVNLAEAA 246
Cdd:cd15147  162 KDNSKPVLIIhFIIIGLFFLVFLLILVCNLVIARTLLSQPVQGQRNAGVkrralwMVCTVLAVFVICFVPHHVVQGPWTL 241
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 966954328 247 RALAGQASGSGLVGQRLKLARSVLIALAFLSSSVNPVLY 285
Cdd:cd15147  242 AVLQQWRYWDCQFRQALNDAHQITLCLMSTNCVLDPVIY 280
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
73-242 2.16e-06

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 48.41  E-value: 2.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  73 FFLHFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATP- 151
Cdd:cd15299   59 LFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPa 138
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 152 VLVYRTVVALKT-NMSLCYPKYPSKEHEAFHlifEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGrlvvlIILAF 230
Cdd:cd15299  139 ILFWQYFVGKRTvPPDECFIQFLSEPIITFG---TAIAAFYLPVTIMTILYWRIYKETIKEKKAAQTLSA-----ILLAF 210
                        170
                 ....*....|..
gi 966954328 231 AAFWLPYHVVNL 242
Cdd:cd15299  211 IITWTPYNIMVL 222
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
89-149 2.43e-06

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 48.40  E-value: 2.43e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966954328  89 GCRLCHYVCGVSMYA---SVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLA 149
Cdd:cd14981   72 GQPLCDYFGFMMSFFglsSLLIVCAMAVERFLAITHPFFYNSHVKKRRARLMLGAVWAFALLIA 135
7tmA_GPR39 cd15135
G protein-coupled receptor 39, member of the class A family of seven-transmembrane G ...
82-154 2.46e-06

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR39 is an orphan G protein-coupled receptor that belongs to the growth hormone secretagogue and neurotensin receptor subfamily. GPR39 is expressed in peripheral tissues such as pancreas, gut, gastrointestinal tract, liver, kidney as well as certain regions of the brain. The divalent metal ion Zn(2+) has been shown to be a ligand capable of activating GPR39. Thus, it has been suggested that GPR39 function as a G(q)-coupled Zn(2+)-sensing receptor which involved in the regulation of endocrine pancreatic function, body weight, gastrointestinal mobility, and cell death.


Pssm-ID: 320263 [Multi-domain]  Cd Length: 320  Bit Score: 48.64  E-value: 2.46e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966954328  82 TWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAgIWVVSFLLATPVLV 154
Cdd:cd15135   70 ATPSGNIACKIYNFLFEACSYATILNVATLSFERYIAICHPFKYKALSGSRVRLLICF-VWLTSALVALPLLF 141
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
72-285 3.27e-06

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 47.73  E-value: 3.27e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  72 PFFLHFLAQ-GTWSFGlagCRLCHYVCG---VSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFL 147
Cdd:cd15053   55 PFAVYVEVNgGKWYLG---PILCDIYIAmdvMCSTASIFNLCAISIDRYIAVTQPIKYARQKNSKRVLLTIAIVWVVSAA 131
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 148 LATPVL-VYRTVVALKTNMSLCYpkypskehEAFHLIFEALTGFLLPFLAVVASYSDIgrrlqaRRFRRSRRTGRLVVLI 226
Cdd:cd15053  132 IACPLLfGLNNVPYRDPEECRFY--------NPDFIIYSSISSFYIPCIVMLLLYYRI------FRALRREKKATKTLAI 197
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 227 IL-AFAAFWLPYHVVNLAEAARALAGQASGSglVGQRLKlarSVLIALAFLSSSVNPVLY 285
Cdd:cd15053  198 VLgVFLFCWLPFFTLNILNAICPKLQNQSCH--VGPALF---SLTTWLGYVNSFLNPIIY 252
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
79-237 3.31e-06

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 47.85  E-value: 3.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  79 AQGTWSFGLAGCRL---CHYVCGVSMYASVLLItamSLDRSLAVARPFVSQKLRTKaMALRVLAGIWVVSFLLATPVLVY 155
Cdd:cd15075   62 AVGYFNLGRVGCVLegfAVAFFGIAALCTVAVI---AVDRLFVVCKPLGTLTFQTR-HALAGIASSWLWSLIWNTPPLFG 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 156 RTVVALKTNMSLCYPKYPSKE-HEAFHLIFEALTGFLLPFLAVVASYS----------DIGRRLQARRFRRSRRTGRLVV 224
Cdd:cd15075  138 WGSYQLEGVMTSCAPDWYSRDpVNVSYILCYFSFCFAIPFAIILVSYGyllwtlrqvaKLGVAEGGSTAKAEVQVARMVV 217
                        170
                 ....*....|...
gi 966954328 225 LIILAFAAFWLPY 237
Cdd:cd15075  218 VMVMAFLLCWLPY 230
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
81-285 6.56e-06

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 46.89  E-value: 6.56e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  81 GTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRV---LAGIWVVSFLLATPVLVYRT 157
Cdd:cd15310   65 GVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVslmITAVWVLAFAVSCPLLFGFN 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 158 VVALKTNMSLCYPKYpskeheafhLIFEALTGFLLPFLAVVASYSDIgrrlqARRFRRSRRTGRLVVLIILAFAAFWLPY 237
Cdd:cd15310  145 TTGDPTVCSISNPDF---------VIYSSVVSFYLPFGVTLLVYVRI-----YVVLLREKKATQMLAIVLGAFIVCWLPF 210
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 966954328 238 HVVNLAEAARALAGQASGsglvgqrlklARSVLIALAFLSSSVNPVLY 285
Cdd:cd15310  211 FLTHILNTHCQACHVPPE----------LYSATTWLGYVNSALNPVIY 248
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
74-285 7.67e-06

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 46.75  E-value: 7.67e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  74 FLHFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVL 153
Cdd:cd15306   58 LLTILFEAMWPLPLVLCPIWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQASQYNSRATAFIKITVVWLISIGIAIPVP 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 154 V--YRTVVALKTNMSLCYPKYPSKEheafHLIFEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILAFA 231
Cdd:cd15306  138 IkgIETDVDNPNNITCVLTKERFGD----FILFGSLAAFFTPLAIMIVTYFLTIHALRKQTITNEQRASKVLGIVFFLFL 213
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 966954328 232 AFWLPYHVVNLAEaarALAGQASGSglvgqRLKLARSVLIALAFLSSSVNPVLY 285
Cdd:cd15306  214 LMWCPFFITNITS---VLCDSCNQT-----TLQMLMEIFVWIGYVSSGVNPLVY 259
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
20-151 8.49e-06

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 46.74  E-value: 8.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  20 LAIILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLltapfFLHFLAQGTW--SFGLAG----CRLC 93
Cdd:cd15385    2 LEIAVLAVIFAVAVIGNSSVLLALYKTKKKASRMHLFIKHLSLADLVVA-----FFQVLPQLCWdiTYRFYGpdflCRIV 76
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 966954328  94 HYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGiWVVSFLLATP 151
Cdd:cd15385   77 KHLQVLGMFASTYMLVMMTADRYIAICHPLKTLQQPTKRSYLMIGSA-WALSFILSTP 133
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
103-286 8.68e-06

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 46.60  E-value: 8.68e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 103 ASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYrTVVALKTNMSLCypKYPSKEHEAFHL 182
Cdd:cd15104   86 ASVLSLAAIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWLYSGLIGFLPLIS-PQFQQTSYKGKC--SFFAAFHPRVLL 162
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 183 IFeALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRL------------------VVLIILAFAAFWLPYHVVNLAE 244
Cdd:cd15104  163 VL-SCMVFFPALLLFVFCYCDILKIARVHSRAIYKVEHALarqihprrtlsdfkaartVAVLIGCFLLSWLPFQITGLVQ 241
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 966954328 245 AaralagqASGSGLVGQrlkLARSVLIALAFLSSSVNPVLYA 286
Cdd:cd15104  242 A-------LCDECKLYD---VLEDYLWLLGLCNSLLNPWIYA 273
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
85-151 8.70e-06

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 46.69  E-value: 8.70e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966954328  85 FGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATP 151
Cdd:cd15358   69 LGAGGCYFKTLLFETVCFASILNVTALSVERYIAVVHPLKAKYVVTRTHAKRVIGAVWVVSILCSIP 135
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
72-149 8.76e-06

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 46.68  E-value: 8.76e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966954328  72 PFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLA 149
Cdd:cd15058   55 PLGATIVVTGKWQLGNFWCELWTSVDVLCVTASIETLCVIAVDRYIAITRPLRYQVLLTKRRARVIVCVVWIVSALVS 132
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
78-285 9.49e-06

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 46.54  E-value: 9.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  78 LAQGTWSFGLagcrlchYVCGVSMYASVLLITA-------MSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLAT 150
Cdd:cd15052   62 LFGGVWPLPL-------VLCLLWVTLDVLFCTAsimhlctISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVWLISIGISS 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 151 PVLVY---RTVVALKTNMslCYPKYPSkeheafHLIFEALTGFLLPFLAVVASYSdigrrlqARRFRRSRRTGRLVVLII 227
Cdd:cd15052  135 PIPVLgiiDTTNVLNNGT--CVLFNPN------FVIYGSIVAFFIPLLIMVVTYA-------LTIRLLSNEQKASKVLGI 199
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 966954328 228 LaFAAF---WLPYHVVNLAEAARALAGQASGSGLVgqrlklarSVLIALAFLSSSVNPVLY 285
Cdd:cd15052  200 V-FAVFvicWCPFFITNILTGLCEECNCRISPWLL--------SVFVWLGYVSSTINPIIY 251
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
85-151 9.59e-06

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 46.75  E-value: 9.59e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966954328  85 FGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATP 151
Cdd:cd15133   69 LGSGGCYFKTFLFETVCLASILNVTALSVERYIAVVHPLAARTCSTRPRVTRVLGCVWGVSMLCALP 135
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
23-286 1.23e-05

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 46.17  E-value: 1.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  23 ILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALA-DLAVLLTAPFFLHFLAQGTWSFGLAGCRL---CHYVCG 98
Cdd:cd15064    5 VLLSLIILATILGNALVIAAILLTRKLHTPANYLIASLAVAdLLVAVLVMPLSAVYELTGRWILGQVLCDIwisLDVTCC 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  99 VsmyASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTvVALKTNMSLCypkYPSKEHE 178
Cdd:cd15064   85 T---ASILHLCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICISLPPLFGWR-TPDSEDPSEC---LISQDIG 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 179 afHLIFEALTGFLLPFLAVVASYSDIgrrlqARRFRRSRRTGRLVVLIILAFAAFWLPYHVVnlaeaarALAGQASGSGL 258
Cdd:cd15064  158 --YTIFSTFGAFYIPLLLMLILYWKI-----YRAAARERKAAKTLGIILGAFIVCWLPFFLV-------ALIVPLCSHCW 223
                        250       260
                 ....*....|....*....|....*...
gi 966954328 259 VGQRLKlarSVLIALAFLSSSVNPVLYA 286
Cdd:cd15064  224 IPLALK---SFFLWLGYFNSLINPLIYT 248
7tmA_GPR141 cd14994
orphan G protein-coupled receptor 141, member of the class A family of seven-transmembrane G ...
22-156 1.38e-05

orphan G protein-coupled receptor 141, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 141 of unknown function. Several ESTs for GPR141 were found in marrow and cancer cells. GPR141 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320125  Cd Length: 275  Bit Score: 45.94  E-value: 1.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  22 IILLSVALAVGLPGNSFVVWsILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVSM 101
Cdd:cd14994    5 IFLYSVVLIGGVIGVILMSF-LLVKMNTRSVTTTAVINLIVVHSLFLLTVPFRIYYYASKTWKFGMPLCKMVSAMIHIHM 83
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 966954328 102 YASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYR 156
Cdd:cd14994   84 HLTFLFYVIILVIRYLIFFQRKDKMEFYRKLHAVAASAVVWVLVLLIVVPVFVKE 138
7tmA_OXER1 cd15200
oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G ...
72-285 1.50e-05

oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; OXER1, also called GPR170, is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. OXER1 is a member of the class A family of seven-transmembrane G-protein coupled receptors and appears to be coupled to the G(i/o) protein. The receptor is expressed in various tissues except brain. Phylogenetic analysis showed that GPR31 and OXER1 are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). OXER1, like GPR31, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike GPR31, does cause increase in the cytosolic calcium level.


Pssm-ID: 320328 [Multi-domain]  Cd Length: 276  Bit Score: 45.92  E-value: 1.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  72 PFFLHFLAQG-TWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLAT 150
Cdd:cd15200   54 PFRIDYYLRNeVWRFGATACQVNLFMLSMNRTASIVFLTAIALNRYLKVVHPHHQLSKASVGCAAKVAAGLWILILLLNI 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 151 PVLVYRTVVALKTNMSLCYPKYPSKEHEAFHLIFeaLTGFLLPFLAVVASYSDIGRRL---QARRFRRSRRTGRLVVLII 227
Cdd:cd15200  134 HLLLLDHVQSNSTCLSYDHGTDPSASDRWHRILF--FLEFFLPLGIILFCIFSIILTLkqrKLAKQAGPQRAVKVLAVIV 211
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 966954328 228 LAFAAFWLPYHVVNLAEAARALAGQASGSGLVGQRLKLArsvlIALAFLSSSVNPVLY 285
Cdd:cd15200  212 LVYTVCFLPSILFALASLVAFKVSQCRSLDLCTQLFHGS----LAFTYLNSALDPVLY 265
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
72-285 1.53e-05

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 45.88  E-value: 1.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  72 PFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATP 151
Cdd:cd15050   55 PLNIVYLLESKWILGRPVCLFWLSMDYVASTASIFSLFILCIDRYRSVQQPLKYLKYRTKTRASLMISGAWLLSFLWVIP 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 152 VLVYRTVvalktnMSLCYPKYPSKEHEA-FH--LIFEALTGFL---LPFLAVVASYSDIgrrlqARRFRRSRRTGRLVVL 225
Cdd:cd15050  135 ILGWHHF------ARGGERVVLEDKCETdFHdvTWFKVLTAILnfyIPSLLMLWFYAKI-----FKAVNRERKAAKQLGF 203
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 226 IILAFAAFWLPYHVVNLAeaaralagQASGSGLVGQRLKLArsvLIALAFLSSSVNPVLY 285
Cdd:cd15050  204 IMAAFILCWIPYFILFMV--------IAFCKNCCNENLHMF---TIWLGYINSTLNPFIY 252
7tmA_GPR34-like cd15920
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G ...
23-285 3.74e-05

P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320586 [Multi-domain]  Cd Length: 278  Bit Score: 44.79  E-value: 3.74e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  23 ILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFlaqGTWSFGLAGCRLCHYVCGVSMY 102
Cdd:cd15920    5 VMYSIICIVGLLSNTLALWVFFLRQQRETSISVYMRNLALADLLLVLCLPFRVAY---QNTAGPLSFCKIVGAFFYLNMY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 103 ASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYrtvvalKTNMSLCYPK---YPSKEHEA 179
Cdd:cd15920   82 ASILFLSLISLDRYLKIIKPLQQFKIHTVPWSSAASGGVWLLLLACMIPFLFE------SRNEGPCDNKcfhFRSKGLTA 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 180 FHLIFEALTGFLLPFLAVVASYSDIGRRLQARRFRRS----------RRTGRLVVLIIlaFAAFWLPYHVVNLaeaARAL 249
Cdd:cd15920  156 GGINLTAVVIFYILSLLFLYFYAKISHKLYKVSLGNAqqqikkaskrAIIKTFIVLAI--FIVCFVPYHIVRV---PYVL 230
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 966954328 250 AGQASGSGLVGQR-LKLARSVLIALAFLSSSVNPVLY 285
Cdd:cd15920  231 AQIDVISSLPWKQtLHIANELVLCLSALNSCLDPIIY 267
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
73-242 3.99e-05

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 44.63  E-value: 3.99e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  73 FFLHFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLL-ATP 151
Cdd:cd15300   56 LYTSYILMGYWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILwAPP 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 152 VLVYRTVVALKT-NMSLCYPKYPSKEHEAFHlifEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGrlvvlIILAF 230
Cdd:cd15300  136 ILCWQYFVGKRTvPERECQIQFLSEPTITFG---TAIAAFYIPVSVMTILYCRIYKETIKERKAAQTLSA-----ILLAF 207
                        170
                 ....*....|..
gi 966954328 231 AAFWLPYHVVNL 242
Cdd:cd15300  208 IITWTPYNIMVL 219
7tmA_FFAR2_FFAR3 cd15170
free fatty acid receptors 2, 3, and similar proteins, member of the class A family of ...
73-201 4.08e-05

free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes free fatty acid receptor 2 (FFAR2), FFAR3, and similar proteins. They are a member of the class A G-protein coupled receptors that bind free fatty acids. The FFAR subfamily is composed of three receptors, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR2 and FFAR3 are cell-surface receptors for short chain FFAs (SCFAs) with different ligand affinities, whereas FFAR1 is a receptor for medium- and long-chain FFAs. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), thus suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320298  Cd Length: 278  Bit Score: 44.56  E-value: 4.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  73 FFLHFL--------AQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVV 144
Cdd:cd15170   49 IFLLFLpfkmaeaaSGMIWPLPYFLCPLSSFIFFSTIYISTLFLTAISVERYLGVAFPIKYKLRRRPLYAVIASVFFWVL 128
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966954328 145 SFLLATPVLV----YRTVVALKTNMSLCYPKYpSKEHEAFHLIF---EALTGFLLPFLAVVASY 201
Cdd:cd15170  129 AFSHCSIVYIveyhIDSENTSVTNNSRCYDNF-TPEQLKILLPVrleLFLVLFCIPFLITCFCY 191
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
19-201 4.39e-05

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 44.74  E-value: 4.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  19 LLAIILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLltapfFLHFLAQGTWSFG---LAG---CRL 92
Cdd:cd15384    1 LLKIVVLAVMFVISFIGNLLTIIQIYRLRRSRRTIYSLLLHLAIADLLVT-----FFCIPSEAIWAYTvawLAGntmCKL 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  93 CHYVCGVSMYASVLLITAMSLDRSLAVARPFvsQKLRTKAMALRVLAGIWVVSFLLATP--VLVYRTVVALKTNMSLC-- 168
Cdd:cd15384   76 VKYLQVFGLYLSTYITVLISLDRCVAILYPM--KRNQAPERVRRMVTVAWILSPIFSIPqaVIFHVERGPFVEDFHQCvt 153
                        170       180       190
                 ....*....|....*....|....*....|...
gi 966954328 169 YPKYPSKEHEAFHLIFEALTGFLLPFLAVVASY 201
Cdd:cd15384  154 YGFYTAEWQEQLYNMLSLVFMFPIPLVIMVTCY 186
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
17-169 4.62e-05

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 44.76  E-value: 4.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  17 IVLLAIILLSVALavglpGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLltapfFLHFLAQGTWSFG--LAG----C 90
Cdd:cd15388    4 IAVLAIIFACALL-----SNSLVLLVLWRRRKQLARMHVFMLHLCIADLVVA-----FFQVLPQLVWDITdrFRGpdvlC 73
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966954328  91 RLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGiWVVSFLLATPVLVYRTVVALKTNMSLCY 169
Cdd:cd15388   74 RLVKYLQVVGMFASSYMIVAMTFDRHQAICRPMVTFQKGRARWNGPVCVA-WAISLILSLPQVFIFSKVEVAPGVYECW 151
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
73-154 4.93e-05

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 44.32  E-value: 4.93e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  73 FFLHFLAQGtWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPV 152
Cdd:cd15336   57 FFVNSLHKR-WIFGEKGCELYAFCGALFGITSMITLLAISLDRYLVITKPLASIRWVSKKRAMIIILLVWLYSLAWSLPP 135

                 ..
gi 966954328 153 LV 154
Cdd:cd15336  136 LF 137
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
19-204 5.78e-05

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 44.10  E-value: 5.78e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  19 LLAIILLsVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCG 98
Cdd:cd15079    2 LLGFIYI-FLGIVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLMMIKMPIFIYNSFYEGWALGPLGCQIYAFLGS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  99 VSMYASVLLITAMSLDRSLAVARPFVSQKLrTKAMALRVLAGIWVVSFLLAT-PVLVYRTVVALKTNMSLCYPKYPSKEH 177
Cdd:cd15079   81 LSGIGSIWTNAAIAYDRYNVIVKPLNGNPL-TRGKALLLILFIWLYALPWALlPLLFGWGRYVPEGFLTSCSFDYLTRDW 159
                        170       180
                 ....*....|....*....|....*...
gi 966954328 178 EA-FHLIFEALTGFLLPFLAVVASYSDI 204
Cdd:cd15079  160 NTrSFVATIFVFAYVIPLIIIIYCYSFI 187
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
19-242 6.05e-05

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 44.19  E-value: 6.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  19 LLAIILLSVALAVGLPGNSFVVWSILKRMKK-RSVTALLVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCR---LCH 94
Cdd:cd15074    1 IIIGIYLTVIGILSTLGNGTVLFVLYRRRSKlKPAELLTVNLAVSDLGISVFGYPLAIISAFAHRWLFGDIGCVfygFCG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  95 YVCGVSmyaSVLLITAMSLDRSLAVARPFVSQKLrTKAMALRVLAGIWVVSFLLATPVLV---------YRTVVALKTNM 165
Cdd:cd15074   81 FLFGCC---SINTLTAISIYRYLKICHPPYGPKL-SRRHVCIVIVAIWLYALFWAVAPLVgwgsygpepFGTSCSIDWTG 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 166 SLCYPKYPSkeheafHLIFEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGR-------------LVVLIILAFAA 232
Cdd:cd15074  157 ASASVGGMS------YIISIFIFCYLLPVLIIVFSYVKIIRKVKSSRKRVAGFDSRskrqhkierkvtkVAVLICAGFLI 230
                        250
                 ....*....|
gi 966954328 233 FWLPYHVVNL 242
Cdd:cd15074  231 AWTPYAVVSM 240
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
90-151 8.10e-05

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 43.65  E-value: 8.10e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966954328  90 CRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMAlrVLAGiWVVSFLLATP 151
Cdd:cd15387   73 CRLVKYLQVVGMFASTYMLLLMSIDRCLAICQPLRSLHRRSDRVY--VLFS-WLLSLVFSIP 131
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
32-156 8.44e-05

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 43.57  E-value: 8.44e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  32 GLPGNsFVVWSILKRMKK-RSVTALLVLNLALADLAVLLTAP--FFLHFLAQgTWSFGLAGCRLCHYVCGVSMYASVLLI 108
Cdd:cd15000   13 GIFGN-FVLLYILASNRSlRTPTNLLIGNMALADLLTLLVCPwmFLVHDFFQ-NYVLGSVGCKLEGFLEGSLLLASVLAL 90
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 966954328 109 TAMSLDRSLAVARPfvsQKLRTKAMALRVLAGI-WVVSFLLATPVLVYR 156
Cdd:cd15000   91 CAVSYDRLTAIVLP---SEARLTKRGAKIVIVItWIVGLLLALPLAIYR 136
7tmA_GPR45 cd15403
G protein-coupled receptor 45, member of the class A family of seven-transmembrane G ...
18-201 8.47e-05

G protein-coupled receptor 45, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR45 and closely related proteins found in vertebrates. GPR45 is also called PSP24 in Xenopus and PSP24-alpha (or PSP24-1) in mammals. GPR45 shows the highest sequence homology with GPR63 (PSP24-beta, or PSP24-2). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320525 [Multi-domain]  Cd Length: 301  Bit Score: 43.68  E-value: 8.47e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  18 VLLAIILLSVaLAVGLPGNSFVVWSILKRMKKRS-VTALLVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYV 96
Cdd:cd15403    1 ILLAIVMILM-IAIGFLGNAIVCLIVYQKPAMRSaINLLLATLAFSDIMLSLLCMPFTAVTIITVDWHFGAHFCRISAML 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  97 CGVSMYASVLLITAMSLDRSLAVARpfvSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALKTNMSLCYPKYPSKE 176
Cdd:cd15403   80 YWFFVLEGVAILLIISVDRFLIIVQ---RQDKLNPHRAKVMIAISWVLSFCISFPSVVGWTLVEVPARAPQCVLGYTESP 156
                        170       180
                 ....*....|....*....|....*
gi 966954328 177 HEAFHLIFEALTGFLLPFLAVVASY 201
Cdd:cd15403  157 ADRVYAVLLVVAVFFVPFSIMLYSY 181
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
18-288 8.76e-05

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 43.73  E-value: 8.76e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  18 VLLAIILlSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALA-DLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYV 96
Cdd:cd15325    1 IVLGVIL-GGFILFGVLGNILVILSVACHRHLQTVTHYFIVNLAVAdLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAV 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  97 CGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLAT-PVLVYRTvvALKTNMSLCypkypSK 175
Cdd:cd15325   80 DVLCCTASIMSLCIISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVLSLVISIgPLFGWKE--PAPEDETIC-----QI 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 176 EHEAFHLIFEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVliILAFAAFWLPYHVVnLAEAARALAGQASG 255
Cdd:cd15325  153 TEEPGYALFSALGSFYLPLAIILVMYCRVYVVALKFSREKKAAKTLGIV--VGCFVLCWLPFFLV-MPIGSIFPAYKPSD 229
                        250       260       270
                 ....*....|....*....|....*....|...
gi 966954328 256 SGLvgqrlklarSVLIALAFLSSSVNPVLYACA 288
Cdd:cd15325  230 TVF---------KITFWLGYFNSCINPIIYPCS 253
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
103-285 9.01e-05

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 43.38  E-value: 9.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 103 ASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYrtvvALKTNMSLCYPKYPSKEHEAFHL 182
Cdd:cd15304   87 ASIMHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVF----GLQDDSKVFKEGSCLLADENFVL 162
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 183 IfEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILaFAAFWLPYHVVNLAEaarALAGQASGSGLVGQR 262
Cdd:cd15304  163 I-GSFVAFFIPLTIMVITYFLTIKSLQQSISNEQKASKVLGIVFFL-FVVMWCPFFITNVMA---VICKESCNEVVIGGL 237
                        170       180
                 ....*....|....*....|...
gi 966954328 263 LKlarsVLIALAFLSSSVNPVLY 285
Cdd:cd15304  238 LN----VFVWIGYLSSAVNPLVY 256
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
80-204 9.40e-05

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 43.46  E-value: 9.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  80 QGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVV 159
Cdd:cd15337   64 NKKWIWGKVACELYGFAGGIFGFMSITTLAAISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWLWSLLWSIPPFFGWGRY 143
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 966954328 160 ALKTNMSLCYPKYPSKEheAFHLIFEA---LTGFLLPFLAVVASYSDI 204
Cdd:cd15337  144 VPEGFQTSCTFDYLSRD--LNNRLFILglfIFGFLCPLLIIIFCYVNI 189
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
12-288 9.89e-05

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 43.25  E-value: 9.89e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  12 LGVGfIVLLAIILLSVAlavglpGNSFVVWSILKRMKKRSVTALLVLNLALA-DLAVLLTAPFFLHFLAQGTWSFGLAGC 90
Cdd:cd15062    1 IVVG-VALGAFILFAIG------GNLLVILSVACNRHLRTPTHYFIVNLAVAdLLLSFTVLPFSATLEVLGYWAFGRIFC 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  91 RLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLAT-PVLVYRTVVAlkTNMSLCy 169
Cdd:cd15062   74 DVWAAVDVLCCTASIMSLCVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVLSLVISIgPLLGWKEPAP--ADEQAC- 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 170 pkypSKEHEAFHLIFEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVliILAFAAFWLPYHVVNLAEAARAL 249
Cdd:cd15062  151 ----GVNEEPGYVLFSSLGSFYLPLAIILVMYCRVYVVAFKFSREKKAAKTLGIV--VGAFVLCWFPFFVVLPLGSLFST 224
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 966954328 250 AGQASGsglvgqrlklARSVLIALAFLSSSVNPVLYACA 288
Cdd:cd15062  225 LKPPEP----------VFKVVFWLGYFNSCLNPIIYPCS 253
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
16-154 1.35e-04

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 43.03  E-value: 1.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  16 FIVLLAIILLSVAlavglpGNSFVVWSIL--KRMKKRSvTALLVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLc 93
Cdd:cd15329    4 GIVLLIIILGTVV------GNALVIIAVClvKKLRTPS-NYLIVSLAVSDLLVALLVMPLAIIYELSGYWPFGEILCDV- 75
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966954328  94 HYVCGVSM-YASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLV 154
Cdd:cd15329   76 WISFDVLLcTASILNLCAISVDRYLVITRPLTYAVKRTPKRMALMIAIVWLLSALISIPPLF 137
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
72-285 1.42e-04

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 42.89  E-value: 1.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  72 PFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTK-AMALRVLAGIWVVSFLLAT 150
Cdd:cd15295   55 PLYIPYTLTNRWDFGRGLCVFWLVIDYLLCTASVYNIVLISYDRYQSVSNAVSYRNQQTAtLRIVTQMVAVWVLAFLVHG 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 151 PVLVYRTVValKTNMSLCYPKYPSKEHeafHLIFEALTGFLLPFLAVVasYSDIGRRLQARRFRRSRRTGRLVVLIILAF 230
Cdd:cd15295  135 PAILVSDSW--KTEDGECEPEFFSNWY---ILAITSVLEFLVPVILVA--YFNTQIYWSLWKRLRDRKLAKSLAIILGTF 207
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 966954328 231 AAFWLPYHVVNLAEAARAlagqasgsglvGQRLKLARSVLIALAFLSSSVNPVLY 285
Cdd:cd15295  208 AICWAPYSLFTIIRAACE-----------KHRGSPWYNFAFWLQWFNSFINPFLY 251
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
83-285 1.44e-04

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 42.95  E-value: 1.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  83 WSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFvSQKLRTKAmALRVLAGIWVVSFLLATPVLV-------- 154
Cdd:cd15980   66 WPFGSTVCKMSGMVQGISVSASVFTLVAIAVDRFRCIVYPF-KQKLTIST-AVVIIVIIWVLAIAIMCPSAVmlhvqeek 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 155 -YRTVVALKTNMS---LCYPKYPSKEHEAFHLIFEALTGFLLPFLAVVASYSDIGRRLQARRFRRS-------------- 216
Cdd:cd15980  144 nYRVVLGSQNKTSpvyWCREDWPNQEMRKIYTTVLFANIYLAPLSLIVIMYARIGITLFKTAMPHTgkhnqeqrhvvsrk 223
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966954328 217 -RRTGRLVVLIILAFAAFWLP-YHVVNLAEAARalagqasgsgLVGQRLKLARSVLIA----LAFLSSSVNPVLY 285
Cdd:cd15980  224 kQKVIKMLLIVALLFILSWLPlWTLMMLSDYAN----------LSPNQLQIINIYIYPfahwLAFFNSSVNPIIY 288
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
85-151 1.53e-04

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 42.93  E-value: 1.53e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966954328  85 FGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATP 151
Cdd:cd15357   69 FGPVGCYFKTALFETVCFASILSVTTVSVERYVAILHPFRAKLNSTRERALKIIVVLWVLSVLFSIP 135
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
103-285 1.59e-04

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 42.97  E-value: 1.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 103 ASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVlvyrTVVALKTNMSLCYPKYPSKEHEAFHL 182
Cdd:cd15305   87 ASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAMMKIAAVWTISIGISMPI----PVIGLQDDEKVFVNGTCVLNDENFVL 162
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 183 IfEALTGFLLPFLAVVASYS-DIGRRLQARRFRRSRRTGRLVVLIILAFAAFWLPYHVVNLAEaarALAGQASGSGLVGQ 261
Cdd:cd15305  163 I-GSFVAFFIPLIIMVITYClTIQVLQRQQAINNERRASKVLGIVFFLFLIMWCPFFITNILS---VLCKEACDQKLMEE 238
                        170       180
                 ....*....|....*....|....
gi 966954328 262 RLklarSVLIALAFLSSSVNPVLY 285
Cdd:cd15305  239 LL----NVFVWVGYVSSGINPLVY 258
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
89-287 1.59e-04

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 43.00  E-value: 1.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  89 GCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAmALRVLAGIWVVSFLLAT-PVLV---YRTVVALKTN 164
Cdd:cd14980   80 PCLLACFLVSLSSLMSVLMMLLITLDRYICIVYPFSNKRLSYKS-AKIILILGWLFSIIFAAiPILYsinQPGDNRLYGY 158
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 165 MSLCYPKYPSKEHEAFHLIFEALTGFLLpFLAVVASYSDI-------GRRLQARRFRRSRRTGRLVVLIILAFAAFWLPY 237
Cdd:cd14980  159 SSICMPSNVSNPYYRGWLIAYLLLTFIA-WIIICILYILIfisvrksRKSARRSSSKRDKRIAIRLALILITDLICWLPY 237
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 966954328 238 HVVNlaeaaraLAGQASGSGLVGQRLKLArsVLIALAfLSSSVNPVLYAC 287
Cdd:cd14980  238 YIVI-------FSGLLTSTEIDIHVLQFI--AILALP-LNSAINPYLYTL 277
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
12-288 1.83e-04

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 42.59  E-value: 1.83e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  12 LGVGfIVLLAIILLSVAlavglpGNSFVVWSILKRMKKRSVTALLVLNLALA-DLAVLLTAPFFLHFLAQGTWSFGLAGC 90
Cdd:cd15327    1 VGVG-VFLAIFILMAIV------GNILVILSVACNRHLQTVTNYFIVNLAIAdLLLSTTVLPFSATLEVLGFWAFGRVFC 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  91 RLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLAT-PVLVYRTVVAlkTNMSLCy 169
Cdd:cd15327   74 DIWAAVDVLCCTASILSLCVISVDRYVGVKHSLKYPTIMTERKAGVILVLLWVSSMVISIgPLLGWKEPPP--PDESIC- 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 170 pkypSKEHEAFHLIFEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIIlaFAAFWLPYH-VVNLAEAARA 248
Cdd:cd15327  151 ----SITEEPGYALFSSLFSFYLPLMVILVMYFRVYVVALKFSREKKAAKTLAIVVGV--FILCWFPFFfVLPLGSFFPA 224
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 966954328 249 LagqasgsglvgQRLKLARSVLIALAFLSSSVNPVLYACA 288
Cdd:cd15327  225 L-----------KPSEMVFKVIFWLGYFNSCVNPIIYPCS 253
7tmA_D2_dopamine_R cd15309
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
72-285 1.90e-04

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320435 [Multi-domain]  Cd Length: 254  Bit Score: 42.33  E-value: 1.90e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  72 PFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFV-SQKLRTKAMALRVLAGIWVVSFLLAT 150
Cdd:cd15309   55 PWVVYLEVVGEWRFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLyNTRYSSKRRVTVMISVVWVLSFAISC 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 151 PVLVYRTvvalKTNMSLCYPKYPSkeheafHLIFEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILaf 230
Cdd:cd15309  135 PLLFGLN----NTDQNECIIANPA------FVVYSSIVSFYVPFIVTLLVYVQIYIVLQKEKKATQMLAIVLGVFIIC-- 202
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 966954328 231 aafWLPY---HVVNLAEAARALAGQASGsglvgqrlklarsvLIALAFLSSSVNPVLY 285
Cdd:cd15309  203 ---WLPFfitHILNMHCDCNIPPALYSA--------------FTWLGYVNSAVNPIIY 243
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
72-149 1.95e-04

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 42.70  E-value: 1.95e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  72 PFFLHFLAQGTWSFGLAGCRLchYVCGVSMY--ASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLA 149
Cdd:cd15051   55 PFSAIYELRGEWPLGPVFCNI--YISLDVMLctASILNLFAISLDRYLAITAPLRYPSRVTPRRVAIALAAIWVVSLAVS 132
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
72-287 2.05e-04

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 42.44  E-value: 2.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  72 PFFLHFLaqgtwsFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLL-AT 150
Cdd:cd15220   60 PFFLGVV------FGEAECRVYIFLSVCLVSASILTISAISVERYYYIVHPMRYEVKMTIGLVAAVLVGVWVKALLLgLL 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 151 PVLVY----RTVVALKTNMSLCYPkyPSKEHEAFHLIFeALTGFLLPFLAVVASYSDIgrrlqaRRFRRSRRTGRLVVLI 226
Cdd:cd15220  134 PVLGWpsygGPAPIAARHCSLHWS--HSGHRGVFVVLF-ALVCFLLPLLLILVVYCGV------FKVFGGGKAALTLAAI 204
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 966954328 227 ILAFAAFWLPYHVVNLAEaarALAGQASGSGlvgqrlkLARSVLIALAFLSSSVNPVLYAC 287
Cdd:cd15220  205 VGQFLCCWLPYFAFHLYS---ALAASPVSGG-------EAEEVVTWLAYSCFAVNPFFYGL 255
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
72-285 2.13e-04

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 42.22  E-value: 2.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  72 PFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATP 151
Cdd:cd15335   55 PLSITYIVMDTWTLGYFICEIWLSVDMTCCTCSILHLCVIALDRYWAITDAIEYARKRTAKRAGLMILTVWTISIFISIP 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 152 VLVYRtvvalkTNMSLCYPKYPSKEHE-AFHLIFEALTGFLLPFLAVVASYSDIgrrlqARRFRRSRRTGRLVVLIILAF 230
Cdd:cd15335  135 PLFWR------NHHDANIPSQCIIQHDhVIYTIYSTFGAFYIPLTLILILYYRI-----YHAASRERKAARILGLILGAF 203
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 966954328 231 AAFWLPYHVVNLaeaaralagqasgsgLVGQRLKLARS----VLIALAFLSSSVNPVLY 285
Cdd:cd15335  204 ILSWLPFFIKEL---------------IVGLSVMTVSPevadFLTWLGYVNSLVNPLLY 247
7tmA_P2Y13 cd15151
P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled ...
81-151 2.57e-04

P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y13 receptor (P2Y13R) is activated by adenosine diphosphate (ADP) and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341327  Cd Length: 284  Bit Score: 42.08  E-value: 2.57e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 966954328  81 GTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATP 151
Cdd:cd15151   63 GPWQLRAFVCRFSAVVFYITMYISIILLGLISFDRYLKIVRPFGKSWVQRVRFAKILSGAVWLVMFLLSVP 133
7tmA_P2Y12-like cd15924
P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of ...
72-204 2.84e-04

P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y12-like receptors as well as closely related orphan receptor, GPR87.


Pssm-ID: 341352 [Multi-domain]  Cd Length: 284  Bit Score: 42.05  E-value: 2.84e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  72 PF-FLHFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLAT 150
Cdd:cd15924   53 PFkILSDAGLGPWQLRTFVCRVTSVLFYFTMYTSIVFLGLISIDRYLKIVRPFKTSFPKSVSFAKILSVVVWALMFLLSL 132
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966954328 151 P--VLVYRTV--------VALKTNMSLcypkypsKEHEAFHLIFEALtgFLLPFLAVVASYSDI 204
Cdd:cd15924  133 PnmILTNQQPreknvkkcSFLKSELGL-------KWHEIVNYICQVI--FWIVFLLMIVCYTAI 187
7tmA_NAGly_R_GPR18 cd15166
N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G ...
21-153 3.00e-04

N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors; N-arachidonyl glycine (NAGly), an endogenous metabolite of the endocannabinoid anandamide, has been identified as an endogenous ligand of the G(i/o) protein-coupled receptor 18 (GPR18). NAGly is involved in directing microglial migration in the CNS through activation of GPR18. NAGly-GPR18 signaling is thought to play an important role in microglial-neuronal communication. Recent studies also show that GPR18 functions as the abnormal cannabidiol (Abn-CBD) receptor. Abn-CBD is a synthetic isomer of cannabidiol and is inactive at cannabinoid receptors (CB1 or CB2), but acts as a selective agonist at GPR18. The NAGly receptor is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320294 [Multi-domain]  Cd Length: 275  Bit Score: 42.12  E-value: 3.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  21 AIILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVS 100
Cdd:cd15166    3 ALVFYSFIFIIGLFVNITALWVFSCTTKKRTTVTVYMMNVALVDLIFILSLPFRMVYYAKDEWPFGDYFCRILGALTVFY 82
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 966954328 101 MYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVL 153
Cdd:cd15166   83 PSIALWLLAFISADRYMAIVQPKHAKELKNTPKAVLACVGVWIMTLASTFPLL 135
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
11-242 3.42e-04

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 41.70  E-value: 3.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  11 SLGVGFIVLLAIILLSVALAvglpgNSFVVWSILKRMKKRS-VTALLVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAG 89
Cdd:cd15333    2 GLKISLAVLLALITLATTLS-----NAFVIATIYLTRKLHTpANYLIASLAVTDLLVSILVMPISIVYTVTGTWTLGQVV 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  90 CRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVAlKTNMSLCY 169
Cdd:cd15333   77 CDIWLSSDITCCTASILHLCVIALDRYWAITDAVEYSKKRTPKRAAVMIALVWVISISISLPPFFWRQAKA-EEEVSECV 155
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966954328 170 pkypSKEHEAFHLIFEALTGFLLPFLAVVASYSDIgrrlQARRFRRSRRTGRLVVLIILAFAAFWLPYHVVNL 242
Cdd:cd15333  156 ----VNTDHILYTVYSTVGAFYIPTLLLIALYGRI----YVEARARERKATKTLGIILGAFIVCWLPFFIISL 220
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
72-155 3.68e-04

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 41.81  E-value: 3.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  72 PFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLA-T 150
Cdd:cd15958   55 PFGATLVVRGRWLYGSFFCELWTSVDVLCVTASIETLCVIAIDRYLAITSPFRYQSLLTRARAKGIVCTVWAISALVSfL 134

                 ....*
gi 966954328 151 PVLVY 155
Cdd:cd15958  135 PIMMH 139
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
90-204 6.09e-04

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 41.32  E-value: 6.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  90 CRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALrVLAGIWVVSFLLATPVLVYRTVVALKTNMSL-- 167
Cdd:cd15386   73 CRAVKYLQVLSMFASTYMLIMMTVDRYIAVCHPLRTLQQPSRQAYL-MIGATWLLSCILSLPQVFIFSLREVDQGSGVld 151
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 966954328 168 CYPKYPSKEHEAFHLIFEALTGFLLPFLAVVASYSDI 204
Cdd:cd15386  152 CWADFGFPWGAKAYITWTTLSIFVLPVAILIVCYSLI 188
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
22-285 6.23e-04

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 41.26  E-value: 6.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  22 IILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALA-DLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVS 100
Cdd:cd15397    4 VVSYSLVMAVGLLGNICLICVIARQKEKTNVTNILIANLSFSdILVCLVCLPFTVVYTLMDYWIFGEVLCKMTPFIQCMS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 101 MYASVLLITAMSLDRSLAVA-----RPFVSQklrtkamALRVLAGIWVVSFLLATPVLVYRTV-----------VALKTN 164
Cdd:cd15397   84 VTVSILSLVLIALERHQLIInptgwKPSVSQ-------AYLAVVVIWMLACFISLPFLAFHILtdepyknlshfFAPLAD 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 165 MSLCYPKYPSKEHEAFHLIFEALTGFLLPFLAVVASYSDI------------GRRLQARRFRRSRRTGRLVVLIILAFAA 232
Cdd:cd15397  157 KAVCTESWPSEHHKLAYTTWLLLFQYCLPLLFILVCYLRIylrlrrrkdmleRRGEYNRRAGHSKRINVMLVSLVAAFAL 236
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 966954328 233 FWLPYHVVNlaeaarALAGQASGSGLVGQRlKLARSVLIALAFLSSSVNPVLY 285
Cdd:cd15397  237 CWLPLNVFN------AIADWNHEAIPHCQH-NLIFSLCHLAAMASTCVNPIIY 282
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
81-288 7.82e-04

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 40.65  E-value: 7.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  81 GTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSfllatpvlvyrTVVA 160
Cdd:cd15326   64 GYWVFGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRHSLQYPTIVTRKRAILALLGVWVLS-----------TVIS 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 161 LKTNMSLCYPKYPSKE-----HEAFHLIFEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIIlaFAAFWL 235
Cdd:cd15326  133 IGPLLGWKEPAPPDDKvceitEEPFYALFSSLGSFYIPLIVILVMYCRVYIVALKFSREKKAAKTLGIVVGM--FILCWL 210
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 966954328 236 PYHVvnlaeaarALAGQASGSGLvgQRLKLARSVLIALAFLSSSVNPVLYACA 288
Cdd:cd15326  211 PFFI--------ALPLGSLFSHL--KPPETLFKIIFWLGYFNSCLNPIIYPCS 253
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
20-151 7.97e-04

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 40.90  E-value: 7.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  20 LAIILLSVALAVGLPGNSFVVWSILK-RMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQG-TWSFGLAGCRLCHYVC 97
Cdd:cd15005    2 LKLTTLGLILCVSLAGNLLFSVLIVRdRSLHRAPYYFLLDLCLADGLRSLACFPFVMASVRHGsGWIYGALSCKVIAFLA 81
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 966954328  98 GVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATP 151
Cdd:cd15005   82 VLFCFHSAFTLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAWTLSVAMAFP 135
7tmA_GPR82 cd14996
orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G ...
23-201 1.15e-03

orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 82 of unknown function. GPR82 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320127 [Multi-domain]  Cd Length: 305  Bit Score: 40.17  E-value: 1.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  23 ILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGT-WSFGLAGCRLCHY----VC 97
Cdd:cd14996    5 IIYSFLFVTGVFGNLLSLWVFLTKISKKTSTHIYLINLVTANLLVCSAMPFQAAYFLKGFyWKYQSTQCRIANFfgtlVI 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  98 GVSMYASVLLITAMSLDRSLAVARPFVSQ----------------KLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVAL 161
Cdd:cd14996   85 HVSMCVSILILSWIAISRYATLMKHDSATqkqscyekifyghflkRFRQPKFARYLCIYIWGVVLCIIIPVVVYYSVREA 164
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 966954328 162 KTNM-SLCYP---KYPSKEHEAFHLIfeALTGFLLPFLAVVASY 201
Cdd:cd14996  165 DEDGeSLCYNrqvELGAKGSQIAGLI--ATTFFFLFFLVVLLSY 206
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
19-286 1.46e-03

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 39.96  E-value: 1.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  19 LLAIILLSVALAVGLPGNSFVVWSI-LKRMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVC 97
Cdd:cd15330    1 IITSLFLGTLILCAIFGNACVVAAIaLERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  98 GVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATPVLVYRTVVALKTNMSLCYPkypSKEH 177
Cdd:cd15330   81 VLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAVLISLTWLIGFSISIPPMLGWRTPEDRSDPDACTI---SKDP 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 178 EafHLIFEALTGFLLPFLAVVASYSDIgrrlqARRFRRSRRTGRLVVLIILAFAAFWLPYHVVNLAeaaraLAGQASGSG 257
Cdd:cd15330  158 G--YTIYSTFGAFYIPLILMLVLYGRI-----FKAAARERKTVKTLGIIMGTFILCWLPFFIVALV-----LPFCESTCH 225
                        250       260
                 ....*....|....*....|....*....
gi 966954328 258 LVgqrlKLARSVLIALAFLSSSVNPVLYA 286
Cdd:cd15330  226 MP----ELLGAIINWLGYSNSLLNPIIYA 250
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
72-204 1.60e-03

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 39.54  E-value: 1.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  72 PFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATP 151
Cdd:cd15322   55 PFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFP 134
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 966954328 152 VLVYRTVVALKTNMSLCypkypSKEHEAFHLIFEALTGFLLPFLAVVASYSDI 204
Cdd:cd15322  135 PLITIEKKSGQPEGPIC-----KINDEKWYIISSCIGSFFAPCLIMVLVYIRI 182
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
78-149 1.61e-03

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 39.89  E-value: 1.61e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966954328  78 LAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLA 149
Cdd:cd15959   61 LLTGHWPLGTTVCELWTSVDVLCVTASIETLCAIAVDRYLAITNPLRYEALVTKRRARTAVCLVWAISAAIS 132
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
72-286 1.96e-03

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 39.25  E-value: 1.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  72 PFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATP 151
Cdd:cd15059   55 PFSLVNELMGYWYFGSVWCEIWLALDVLFCTASIVNLCAISLDRYWSVTQAVEYNLKRTPRRAKAMIAAVWIISAVISLP 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 152 VLVYRTVvalKTNMSLCYPKYPSKEhEAFHLIFEALTGFLLPFLAVVASYSDIgrrlQARRFRRSRRTGRLVVLIILAFA 231
Cdd:cd15059  135 PLFGWKD---EQPWHGAEPQCELSD-DPGYVLFSSIGSFYIPLLIMIIVYARI----YRAAKRKERRFTLVLGVVMGAFV 206
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 966954328 232 AFWLPYHVVNLAEAaralagqasgsglVGQRLKLARSVL---IALAFLSSSVNPVLYA 286
Cdd:cd15059  207 LCWLPFFFTYPLVV-------------VCKTCGVPELLFkffFWLGYCNSALNPVIYT 251
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
17-151 2.05e-03

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 39.37  E-value: 2.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  17 IVLLAIILLSVAlavglpGNSFVVWSILKRMKKRSVTALLVLNLALA-DLAVLLTAPF-FLHFLAQGTWSFGLAGCRLCH 94
Cdd:cd15212    5 LVLLAIFLLSSL------GNCAVIGVIVKHRQLRTVTNAFILSLSLSdLLTALLCLPFaFLTLFSRPGWLFGDRLCLANG 78
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 966954328  95 YVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALrvLAGIWVVSFLLATP 151
Cdd:cd15212   79 FFNACFGIVSTLTMTLISFDRYYAIVRQPQGKIGRRRALQL--LAAAWLTALGFSLP 133
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
14-147 2.06e-03

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 39.46  E-value: 2.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  14 VGFIVLLAIILLSVALavglpGNSFVVWSILKRMKKRSVTALLVLNLALA-DLAVLLTAPFFLHFLAQGTWSFGLAGCRL 92
Cdd:cd15957    1 VGMGIVMSLIVLAIVF-----GNVLVITAIAKFERLQTVTNYFITSLACAdLVMGLAVVPFGAAHILLKTWTFGNFWCEF 75
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 966954328  93 CHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFL 147
Cdd:cd15957   76 WTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGL 130
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
80-149 3.10e-03

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 38.87  E-value: 3.10e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966954328  80 QGTWSFGLAGCRLchYVCGVSMY--ASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLA 149
Cdd:cd15065   62 LGYWLFGETFCNI--WISFDVMCstASILNLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSALIS 131
7tmA_GPR20 cd15163
G protein-coupled receptor 20, member of the class A family of seven-transmembrane G ...
85-157 3.83e-03

G protein-coupled receptor 20, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan GPR20 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR20 has been shown to constitutively activate G(i) proteins in the absence of a ligand; however its functional role is not known. GPR20 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320291 [Multi-domain]  Cd Length: 258  Bit Score: 38.62  E-value: 3.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  85 FGLAGCRLCHYV----CGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIW----VVSFLLATPVLVYR 156
Cdd:cd15163   61 YSAGNCLTCSFVhifsYFVNMYCSILFLTCICVDRYLAIVQVEASRRWRNPNYAKGICVFIWlfaiVVTFSILTTAIKFA 140

                 .
gi 966954328 157 T 157
Cdd:cd15163  141 S 141
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
17-149 4.41e-03

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 38.56  E-value: 4.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  17 IVLLAIILLSVAlavglpGNSFVVWSILK--RMKKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGTWSFGlAGCRLch 94
Cdd:cd15057    5 CILYLLVLLTLL------GNALVIAAVLRfrHLRSKVTNYFIVSLAVSDLLVAILVMPWAAVNEVAGYWPFG-SFCDV-- 75
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 966954328  95 YVCGVSM--YASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLA 149
Cdd:cd15057   76 WVSFDIMcsTASILNLCVISVDRYWAISSPFRYERRMTRRRAFIMIAVAWTLSALIS 132
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
103-286 5.68e-03

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 37.99  E-value: 5.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 103 ASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLA-TPVLVYRTVVAL----------KTNMSLCYPK 171
Cdd:cd15069   84 SSIFSLLAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLAFGIGlTPFLGWNKAMSAtnnstnpadhGTNHSCCLIS 163
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 172 --YPSKEHEAFHLIFEALTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVL------------IILAFAAFWLPY 237
Cdd:cd15069  164 clFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLqreihaakslaiIVGIFALCWLPV 243
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 966954328 238 HVVNLAEAARALAGQAsgsglvgqRLKLARSVLIALAFLSSSVNPVLYA 286
Cdd:cd15069  244 HILNCITLFQPEFSKS--------KPKWAMNVAILLSHANSVVNPIVYA 284
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
72-285 6.28e-03

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 38.00  E-value: 6.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  72 PFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATP 151
Cdd:cd15214   54 PFVVTSSIRREWIFGVVWCNFSALLYLLISSASMLTLGAIAIDRYYAVLYPMVYPMKITGNRAVLALVYIWLHSLIGCLP 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 152 VLVYRTVVALKTNMSLCYPKYpskEHEAFHLIFEALTGFLLPFLAVVASYSDIgrrlQARRFRRSRRTGRLVVLIILAFA 231
Cdd:cd15214  134 PLFGWSSLEFDRFKWMCVAAW---HKEAGYTAFWQVWCALLPFVVMLVCYGFI----FRVARANQCKAFITILVVLGAFV 206
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 966954328 232 AFWLPYHVVNLAEaarALAGQASGSGLVgqrlklaRSVLIALAFLSSSVNPVLY 285
Cdd:cd15214  207 TTWGPYMVVISTE---ALWGKNSVSPQL-------ETLATWLSFTSAVCHPLIY 250
7tmA_RXFP2_LGR8 cd15966
relaxin receptor 2 (or LGR8), member of the class A family of seven-transmembrane G ...
90-202 6.57e-03

relaxin receptor 2 (or LGR8), member of the class A family of seven-transmembrane G protein-coupled receptors; Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural similarity, but low sequence similarity, and exert their physiological functions by activating a group of four G protein-coupled receptors, RXFP1-4. INSL3 is the endogenous ligand for RXFP2, which couples to the G(s) protein to increase intracellular cAMP levels, but also to the GoB protein to decrease cAMP formation. RXFP2 (or LGR8) is expressed in various tissues including the brain, kidney, muscle, testis, thyroid, uterus, and peripheral blood cells, among others.


Pssm-ID: 320632  Cd Length: 287  Bit Score: 37.84  E-value: 6.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  90 CRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFvSQKLRTKAMALRVLAGIWVVSFLLAT-PVLVYRTVVALKTNMSLC 168
Cdd:cd15966   80 CRIIGFLAMLSTEVSVLLLTYLTLEKYLVIVFPF-SNIRPGKCQTLIILISIWLVGFIIAViPFWNEDFFGNYYGKNGVC 158
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 966954328 169 YPKYPSKEHEAFHL-----IFEALTgfLLPFLAVVASYS 202
Cdd:cd15966  159 FPLHSDQTEKIGAKgystgIFLGLN--LLAFIIIVFSYS 195
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
24-151 8.24e-03

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 37.52  E-value: 8.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  24 LLSVALAVGLPGNSFVVWSILKRMKKR-SVTALLVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVSMY 102
Cdd:cd15400    6 VLIFTTVVDILGNLLVIISVFRNRKLRnSGNVFVVSLALADLVVALYPYPLVLVAIFHNGWALGEMHCKVSGFVMGLSVI 85
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 966954328 103 ASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLATP 151
Cdd:cd15400   86 GSIFNITGIAINRYCYICHSFAYDKLYSRWNTLLYVCLIWALTVVAIVP 134
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
19-285 8.52e-03

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 37.50  E-value: 8.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  19 LLAIILLSVALAVGLPGNSFVVWSILKRMKKRSVTALLVLNLALA-DLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVC 97
Cdd:cd15396    1 FLLIIAYSVVTIVGLFGNLCLITIIKKQKEEHNVTNILIANLSLSdVLVCVMCIPFTAVYTLMDHWIFGETMCKLTSFVQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  98 GVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLagIWVVSFLLATPVLVYRTVV-----------ALKTNMS 166
Cdd:cd15396   81 SVSVSVSIFSLVLIAIERYQLIVNPRGWKPSASHAYWGIVL--IWLFSLMISIPFLIFHQLTdepfrnlsshsDFYKDKV 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 167 LCYPKYPSKEHEAFHLIFEALTGFLLPFLAVVASYSDIGRRLQA------------RRFRRSRRTGRLVVLIILAFAAFW 234
Cdd:cd15396  159 VCIEAWPSETERLIFTTSLLVFQYFVPLGFIFICYLKIFVCLKKrnskidrmreneSRLSENKRINTMLISIVVTFAACW 238
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 966954328 235 LPYHVVNlaeaaraLAGQASGSGLVGQRLKLARSVLIALAFLSSSVNPVLY 285
Cdd:cd15396  239 LPLNIFN-------VVFDWNHEVLMSCHHNLVFTLCHLVAMVSTCINPIFY 282
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
72-285 9.51e-03

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 37.46  E-value: 9.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  72 PFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARP--FVSQKLRTKAMALRVLAgIWVVSFLLA 149
Cdd:cd15296   55 PLYIPYVLTGRWKFGRGLCKLWLVVDYLLCTASVFNIVLISYDRFLSVTRAvsYRAQKGMTRQAVLKMVL-VWVLAFLLY 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 150 TPVLVYRTVVALKTNM--SLCYPKYpskEHEAFHLIFEALTGFLLPFLAV----VASYSDIGRRLQARRFRRSRRTGRLV 223
Cdd:cd15296  134 GPAIISWEYIAGGSIIpeGECYAEF---FYNWYFLMTASTLEFFTPFISVtyfnLSIYLNIQKRRFRLSRDKKVAKSLAI 210
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966954328 224 vlIILAFAAFWLPYHVVNLAEAAraLAGQASGSGLVgqrlklarSVLIALAFLSSSVNPVLY 285
Cdd:cd15296  211 --IVCVFGLCWAPYTLLMIIRAA--CHGHCVPDYWY--------ETSFWLLWVNSAINPVLY 260
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
99-286 9.78e-03

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 37.27  E-value: 9.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328  99 VSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMALRVLAGIWVVSFLLAT-PVLVYRTVVALKTNMSLCYPKYPsKEH 177
Cdd:cd14972   79 LSLLASAYSLLAIAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLALlPVLGWNCVLCDQESCSPLGPGLP-KSY 157
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966954328 178 EAFHLIFealtgFLLPFLAVVASY-----------SDIGRRLQARRFRRSRRTGRL---VVLIILAFAAFWLPYHVVNLA 243
Cdd:cd14972  158 LVLILVF-----FFIALVIIVFLYvrifwclwrhaNAIAARQEAAVPAQPSTSRKLaktVVIVLGVFLVCWLPLLILLVL 232
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 966954328 244 EaaralagqaSGSGLVGQRLKLARSVLIaLAFLSSSVNPVLYA 286
Cdd:cd14972  233 D---------VLCPSVCDIQAVFYYFLV-LALLNSAINPIIYA 265
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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