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Conserved domains on  [gi|966951040|ref|XP_014997402|]
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thrombospondin-1 [Macaca mulatta]

Protein Classification

thrombospondin type-1 domain-containing protein( domain architecture ID 10641979)

thrombospondin type-1 domain-containing protein similar to Plasmodium circumsporozoite protein that is an essential sporozoite protein required for development of malaria sporozoites in mosquitoes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TSP_C pfam05735
Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and ...
 972-1169 3.03e-117

Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and related proteins.


:

Pssm-ID: 461725  Cd Length: 198  Bit Score: 361.18  E-value: 3.03e-117
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966951040   972 QNDPNWVVRHQGKELVQTVNCDPGLAVGYDEFNAVDFSGTFFINTERDDDYAGFVFGYQSSSRFYVVMWKQVTQSYWDTN 1051
Cdd:pfam05735    1 QIDPIWVIRNQGREIQQTDNSDPGLAIGFDRFGSVDFSGTFFVNTDDDDDYIGFVFGYQSNSKFYVVMWKQVNQSYWPFK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966951040  1052 PTRAQGYSGLSVKVVNSTTGPGEHLRNALWHTGNTPGQVRTLWHDPRHIGWKDFTAYRWRLSHRPKTGFIRVVMYEGKKI 1131
Cdd:pfam05735   81 PFRATGLKGIQLKVVKSTTGPGENLRNALWHTGDTTNQVRLLWHDPTWRGWKDRTAYRWHLQHRPSIGLIRVRVYEGITL 160

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 966951040  1132 MADSGPIYDKTYAGGRLGLFVFSQEMVFFSDLKYECRD 1169
Cdd:pfam05735  161 LADSGNVYDTTIRGGRLGVFCFSQENVIWSDLKYKCLD 198
TSPN smart00210
Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of ...
 26-221 1.15e-49

Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of thrombospondin


:

Pssm-ID: 214560  Cd Length: 184  Bit Score: 174.08  E-value: 1.15e-49
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966951040     26 GDNSVFDIFELTGAARKGSGRRlvkgpdPSSPAFRIEDanliPPVPDDKFQDLVDaVRAEKGFLLLASLRQMKKTRGTLL 105
Cdd:smart00210    3 DLLQVFDLPSLSFAIRQVVGPE------PGSPAYRLGD----PALVPQPTRDLFP-SGLPEDFSLLTTFRQTPKSRGVLF 71

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966951040    106 ALERKDhSGQVFSVVSNGKAGTLDLS-LTVQGKQHVVSVEEALLATGQWKSITLFVQEDRAQLYIDCEKMENAELDVPIQ 184
Cdd:smart00210   72 AIYDAQ-NVRQFGLEVDGRANTLLLRyQGVDGKQHTVSFRNLPLADGQWHKLALSVSGSSATLYVDCNEIDSRPLDRPGQ 150

                           170       180       190
                    ....*....|....*....|....*....|....*..
gi 966951040    185 svfTRDLASIARLRIAKGGVNDNFQGVLQNVRFVFGT 221
Cdd:smart00210  151 ---PPIDTDGIEVRGAQAADRKPFQGDLQQLKIVCDP 184
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 438-490 3.43e-18

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 79.17  E-value: 3.43e-18
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 966951040    438 WSHWSPWSSCSVTCGDGVITRIRLCNSPSPQMNGKPCEGEARETKACKKDACP 490
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 495-547 5.22e-18

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 78.78  E-value: 5.22e-18
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 966951040    495 WGPWSPWDICSVTCGGGVQKRSRLCNNPTPQFGGKDCIGDVTENQICNKQDCP 547
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 318-372 1.86e-17

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


:

Pssm-ID: 278520  Cd Length: 57  Bit Score: 77.46  E-value: 1.86e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 966951040   318 CYHNGVQYRNNEEWTVDSCTECRCQNSVTICKKVSCPIMPCSNAT--VPDGECCPRC 372
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRleIPPGECCPVC 57
TSP_1 pfam00090
Thrombospondin type 1 domain;
383-428 1.01e-12

Thrombospondin type 1 domain;


:

Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 63.59  E-value: 1.01e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 966951040   383 SPWSEWTSCSTSCGNGIQQRGRSCDSL---NNRCEGSSVQTRTCHIQEC 428
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPfpgGEPCTGDDIETQACKMDKC 49
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 846-882 2.52e-09

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


:

Pssm-ID: 367074  Cd Length: 36  Bit Score: 53.52  E-value: 2.52e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 966951040   846 DSDSDRIGDTCDNnqDIDEDGHQNNLDNCPYVPNANQ 882
Cdd:pfam02412    2 DSDSDGVGDACDN--DFDNDGVPDLLDNCPNNANIDQ 36
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 786-821 1.53e-08

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


:

Pssm-ID: 367074  Cd Length: 36  Bit Score: 51.21  E-value: 1.53e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 966951040   786 ADTDSNGEGDACAADIDGDGILNERDNCQYVYNVDQ 821
Cdd:pfam02412    1 TDSDSDGVGDACDNDFDNDGVPDLLDNCPNNANIDQ 36
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 919-952 5.55e-07

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


:

Pssm-ID: 367074  Cd Length: 36  Bit Score: 46.97  E-value: 5.55e-07
                           10        20        30
                   ....*....|....*....|....*....|....
gi 966951040   919 KDSDGDGRGDACKDDFDHDNVPDIDDICPENVDI 952
Cdd:pfam02412    1 TDSDSDGVGDACDNDFDNDGVPDLLDNCPNNANI 34
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 650-689 1.13e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 46.05  E-value: 1.13e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 966951040   650 CTDGTHDCNKNAKCNYlghySDPMYRCECKPGYAGNGIIC 689
Cdd:pfam12947    1 CSDNNGGCHPNATCTN----TGGSFTCTCNDGYTGDGVTC 36
MSCRAMM_ClfA super family cl41352
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 692-976 6.37e-03

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


The actual alignment was detected with superfamily member NF033609:

Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 40.66  E-value: 6.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966951040  692 DTDLDGWPNEDLVCVANATYHCKKDNCPNLPNSGQEDYDKDGIGDACDDDDDNDKIPDDRDNCPFHYNPAQYDYDRDDVG 771
Cdd:NF033609  625 ASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 704

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966951040  772 DRCDNCPYNHNPDqADTDSNGEGDAcAADIDGDgilNERDNCQYVYNVDQRDTDMDGVGDQCDNCPLEHNPDQlDSDSDR 851
Cdd:NF033609  705 DSDSDSDSDSDSD-SDSDSDSDSDS-DSDSDSD---SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS-DSDSDS 778

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966951040  852 IGDTcDNNQDIDEDghqnnldncpyvpnaNQADHDKDGKGDACDHDDDNDGIPDDRDNCRLVPNPDQKDSDGDGRGDACK 931
Cdd:NF033609  779 DSDS-DSDSDSDSD---------------SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 842

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 966951040  932 D-DFDHDNVPDIDDICPENVDiSETDFRRFQMIPLDPK-GTSQNDPN 976
Cdd:NF033609  843 DsDSDSDSDSDSDSESDSNSD-SESGSNNNVVPPNSPKnGTNASNKN 888
 
Name Accession Description Interval E-value
TSP_C pfam05735
Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and ...
 972-1169 3.03e-117

Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and related proteins.


Pssm-ID: 461725  Cd Length: 198  Bit Score: 361.18  E-value: 3.03e-117
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966951040   972 QNDPNWVVRHQGKELVQTVNCDPGLAVGYDEFNAVDFSGTFFINTERDDDYAGFVFGYQSSSRFYVVMWKQVTQSYWDTN 1051
Cdd:pfam05735    1 QIDPIWVIRNQGREIQQTDNSDPGLAIGFDRFGSVDFSGTFFVNTDDDDDYIGFVFGYQSNSKFYVVMWKQVNQSYWPFK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966951040  1052 PTRAQGYSGLSVKVVNSTTGPGEHLRNALWHTGNTPGQVRTLWHDPRHIGWKDFTAYRWRLSHRPKTGFIRVVMYEGKKI 1131
Cdd:pfam05735   81 PFRATGLKGIQLKVVKSTTGPGENLRNALWHTGDTTNQVRLLWHDPTWRGWKDRTAYRWHLQHRPSIGLIRVRVYEGITL 160

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 966951040  1132 MADSGPIYDKTYAGGRLGLFVFSQEMVFFSDLKYECRD 1169
Cdd:pfam05735  161 LADSGNVYDTTIRGGRLGVFCFSQENVIWSDLKYKCLD 198
TSPN smart00210
Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of ...
 26-221 1.15e-49

Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of thrombospondin


Pssm-ID: 214560  Cd Length: 184  Bit Score: 174.08  E-value: 1.15e-49
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966951040     26 GDNSVFDIFELTGAARKGSGRRlvkgpdPSSPAFRIEDanliPPVPDDKFQDLVDaVRAEKGFLLLASLRQMKKTRGTLL 105
Cdd:smart00210    3 DLLQVFDLPSLSFAIRQVVGPE------PGSPAYRLGD----PALVPQPTRDLFP-SGLPEDFSLLTTFRQTPKSRGVLF 71

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966951040    106 ALERKDhSGQVFSVVSNGKAGTLDLS-LTVQGKQHVVSVEEALLATGQWKSITLFVQEDRAQLYIDCEKMENAELDVPIQ 184
Cdd:smart00210   72 AIYDAQ-NVRQFGLEVDGRANTLLLRyQGVDGKQHTVSFRNLPLADGQWHKLALSVSGSSATLYVDCNEIDSRPLDRPGQ 150

                           170       180       190
                    ....*....|....*....|....*....|....*..
gi 966951040    185 svfTRDLASIARLRIAKGGVNDNFQGVLQNVRFVFGT 221
Cdd:smart00210  151 ---PPIDTDGIEVRGAQAADRKPFQGDLQQLKIVCDP 184
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 438-490 3.43e-18

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 79.17  E-value: 3.43e-18
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 966951040    438 WSHWSPWSSCSVTCGDGVITRIRLCNSPSPQMNGKPCEGEARETKACKKDACP 490
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 495-547 5.22e-18

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 78.78  E-value: 5.22e-18
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 966951040    495 WGPWSPWDICSVTCGGGVQKRSRLCNNPTPQFGGKDCIGDVTENQICNKQDCP 547
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 318-372 1.86e-17

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 77.46  E-value: 1.86e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 966951040   318 CYHNGVQYRNNEEWTVDSCTECRCQNSVTICKKVSCPIMPCSNAT--VPDGECCPRC 372
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRleIPPGECCPVC 57
TSP_1 pfam00090
Thrombospondin type 1 domain;
439-489 1.81e-16

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 74.38  E-value: 1.81e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 966951040   439 SHWSPWSSCSVTCGDGVITRIRLCNSPSPQmnGKPCEGEARETKACKKDAC 489
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFPG--GEPCTGDDIETQACKMDKC 49
VWC smart00214
von Willebrand factor (vWF) type C domain;
318-372 1.22e-14

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 69.47  E-value: 1.22e-14
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 966951040    318 CYHNGVQYRNNEEWTVDSCTECRCQNSVTI-CKKVSCPIMP-CSNAT--VPDGECCPRC 372
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTTVlCDPVECPPPPdCPNPErvKPPGECCPRC 59
TSP_1 pfam00090
Thrombospondin type 1 domain;
496-546 2.45e-14

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 68.21  E-value: 2.45e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 966951040   496 GPWSPWDICSVTCGGGVQKRSRLCNNPTPqfGGKDCIGDVTENQICNKQDC 546
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQACKMDKC 49
TSP_1 pfam00090
Thrombospondin type 1 domain;
383-428 1.01e-12

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 63.59  E-value: 1.01e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 966951040   383 SPWSEWTSCSTSCGNGIQQRGRSCDSL---NNRCEGSSVQTRTCHIQEC 428
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPfpgGEPCTGDDIETQACKMDKC 49
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 382-429 3.24e-12

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 62.22  E-value: 3.24e-12
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 966951040    382 WSPWSEWTSCSTSCGNGIQQRGRSCDSLNNR-----CEGSSVQTRTCHIQECD 429
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQngggpCTGEDVETRACNEQPCP 53
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 846-882 2.52e-09

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 53.52  E-value: 2.52e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 966951040   846 DSDSDRIGDTCDNnqDIDEDGHQNNLDNCPYVPNANQ 882
Cdd:pfam02412    2 DSDSDGVGDACDN--DFDNDGVPDLLDNCPNNANIDQ 36
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 786-821 1.53e-08

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 51.21  E-value: 1.53e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 966951040   786 ADTDSNGEGDACAADIDGDGILNERDNCQYVYNVDQ 821
Cdd:pfam02412    1 TDSDSDGVGDACDNDFDNDGVPDLLDNCPNNANIDQ 36
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 919-952 5.55e-07

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 46.97  E-value: 5.55e-07
                           10        20        30
                   ....*....|....*....|....*....|....
gi 966951040   919 KDSDGDGRGDACKDDFDHDNVPDIDDICPENVDI 952
Cdd:pfam02412    1 TDSDSDGVGDACDNDFDNDGVPDLLDNCPNNANI 34
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 650-689 1.13e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 46.05  E-value: 1.13e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 966951040   650 CTDGTHDCNKNAKCNYlghySDPMYRCECKPGYAGNGIIC 689
Cdd:pfam12947    1 CSDNNGGCHPNATCTN----TGGSFTCTCNDGYTGDGVTC 36
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 496-517 2.47e-03

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 41.87  E-value: 2.47e-03
                          10        20
                  ....*....|....*....|..
gi 966951040  496 GPWSPWDICSVTCGGGVQKRSR 517
Cdd:PTZ00441  241 GPWDEWTPCSVTCGKGTHSRSR 262
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 124-217 5.79e-03

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 38.17  E-value: 5.79e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966951040   124 KAGTLDLSLTVQGKQHVVSVEEALLATGQWKSITLFVQEDRAQLYID-CEKMENAELDVPIQSVFTRDL---ASIARLRI 199
Cdd:pfam02210   26 VNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDgQTVVSSLPPGESLLLNLNGPLylgGLPPLLLL 105

                           90
                   ....*....|....*...
gi 966951040   200 AKGGVNDNFQGVLQNVRF 217
Cdd:pfam02210  106 PALPVRAGFVGCIRDVRV 123
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 692-976 6.37e-03

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 40.66  E-value: 6.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966951040  692 DTDLDGWPNEDLVCVANATYHCKKDNCPNLPNSGQEDYDKDGIGDACDDDDDNDKIPDDRDNCPFHYNPAQYDYDRDDVG 771
Cdd:NF033609  625 ASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 704

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966951040  772 DRCDNCPYNHNPDqADTDSNGEGDAcAADIDGDgilNERDNCQYVYNVDQRDTDMDGVGDQCDNCPLEHNPDQlDSDSDR 851
Cdd:NF033609  705 DSDSDSDSDSDSD-SDSDSDSDSDS-DSDSDSD---SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS-DSDSDS 778

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966951040  852 IGDTcDNNQDIDEDghqnnldncpyvpnaNQADHDKDGKGDACDHDDDNDGIPDDRDNCRLVPNPDQKDSDGDGRGDACK 931
Cdd:NF033609  779 DSDS-DSDSDSDSD---------------SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 842

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 966951040  932 D-DFDHDNVPDIDDICPENVDiSETDFRRFQMIPLDPK-GTSQNDPN 976
Cdd:NF033609  843 DsDSDSDSDSDSDSESDSNSD-SESGSNNNVVPPNSPKnGTNASNKN 888
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 124-217 9.33e-03

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 38.17  E-value: 9.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966951040  124 KAGTLDLSLTVQGKQHVVSVEEaLLATGQWKSITLFVQEDRAQLYIDCEKMENAELDVPIQSVFTRDL----ASIARLRI 199
Cdd:cd00110    54 EDGRLVLRYDLGSGSLVLSSKT-PLNDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPlylgGLPEDLKS 132

                          90
                  ....*....|....*...
gi 966951040  200 AKGGVNDNFQGVLQNVRF 217
Cdd:cd00110   133 PGLPVSPGFVGCIRDLKV 150
 
Name Accession Description Interval E-value
TSP_C pfam05735
Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and ...
 972-1169 3.03e-117

Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and related proteins.


Pssm-ID: 461725  Cd Length: 198  Bit Score: 361.18  E-value: 3.03e-117
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966951040   972 QNDPNWVVRHQGKELVQTVNCDPGLAVGYDEFNAVDFSGTFFINTERDDDYAGFVFGYQSSSRFYVVMWKQVTQSYWDTN 1051
Cdd:pfam05735    1 QIDPIWVIRNQGREIQQTDNSDPGLAIGFDRFGSVDFSGTFFVNTDDDDDYIGFVFGYQSNSKFYVVMWKQVNQSYWPFK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966951040  1052 PTRAQGYSGLSVKVVNSTTGPGEHLRNALWHTGNTPGQVRTLWHDPRHIGWKDFTAYRWRLSHRPKTGFIRVVMYEGKKI 1131
Cdd:pfam05735   81 PFRATGLKGIQLKVVKSTTGPGENLRNALWHTGDTTNQVRLLWHDPTWRGWKDRTAYRWHLQHRPSIGLIRVRVYEGITL 160

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 966951040  1132 MADSGPIYDKTYAGGRLGLFVFSQEMVFFSDLKYECRD 1169
Cdd:pfam05735  161 LADSGNVYDTTIRGGRLGVFCFSQENVIWSDLKYKCLD 198
TSPN smart00210
Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of ...
 26-221 1.15e-49

Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of thrombospondin


Pssm-ID: 214560  Cd Length: 184  Bit Score: 174.08  E-value: 1.15e-49
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966951040     26 GDNSVFDIFELTGAARKGSGRRlvkgpdPSSPAFRIEDanliPPVPDDKFQDLVDaVRAEKGFLLLASLRQMKKTRGTLL 105
Cdd:smart00210    3 DLLQVFDLPSLSFAIRQVVGPE------PGSPAYRLGD----PALVPQPTRDLFP-SGLPEDFSLLTTFRQTPKSRGVLF 71

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966951040    106 ALERKDhSGQVFSVVSNGKAGTLDLS-LTVQGKQHVVSVEEALLATGQWKSITLFVQEDRAQLYIDCEKMENAELDVPIQ 184
Cdd:smart00210   72 AIYDAQ-NVRQFGLEVDGRANTLLLRyQGVDGKQHTVSFRNLPLADGQWHKLALSVSGSSATLYVDCNEIDSRPLDRPGQ 150

                           170       180       190
                    ....*....|....*....|....*....|....*..
gi 966951040    185 svfTRDLASIARLRIAKGGVNDNFQGVLQNVRFVFGT 221
Cdd:smart00210  151 ---PPIDTDGIEVRGAQAADRKPFQGDLQQLKIVCDP 184
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 438-490 3.43e-18

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 79.17  E-value: 3.43e-18
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 966951040    438 WSHWSPWSSCSVTCGDGVITRIRLCNSPSPQMNGKPCEGEARETKACKKDACP 490
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 495-547 5.22e-18

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 78.78  E-value: 5.22e-18
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 966951040    495 WGPWSPWDICSVTCGGGVQKRSRLCNNPTPQFGGKDCIGDVTENQICNKQDCP 547
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 318-372 1.86e-17

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 77.46  E-value: 1.86e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 966951040   318 CYHNGVQYRNNEEWTVDSCTECRCQNSVTICKKVSCPIMPCSNAT--VPDGECCPRC 372
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRleIPPGECCPVC 57
TSP_1 pfam00090
Thrombospondin type 1 domain;
439-489 1.81e-16

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 74.38  E-value: 1.81e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 966951040   439 SHWSPWSSCSVTCGDGVITRIRLCNSPSPQmnGKPCEGEARETKACKKDAC 489
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFPG--GEPCTGDDIETQACKMDKC 49
VWC smart00214
von Willebrand factor (vWF) type C domain;
318-372 1.22e-14

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 69.47  E-value: 1.22e-14
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 966951040    318 CYHNGVQYRNNEEWTVDSCTECRCQNSVTI-CKKVSCPIMP-CSNAT--VPDGECCPRC 372
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTTVlCDPVECPPPPdCPNPErvKPPGECCPRC 59
TSP_1 pfam00090
Thrombospondin type 1 domain;
496-546 2.45e-14

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 68.21  E-value: 2.45e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 966951040   496 GPWSPWDICSVTCGGGVQKRSRLCNNPTPqfGGKDCIGDVTENQICNKQDC 546
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQACKMDKC 49
TSP_1 pfam00090
Thrombospondin type 1 domain;
383-428 1.01e-12

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 63.59  E-value: 1.01e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 966951040   383 SPWSEWTSCSTSCGNGIQQRGRSCDSL---NNRCEGSSVQTRTCHIQEC 428
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPfpgGEPCTGDDIETQACKMDKC 49
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 382-429 3.24e-12

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 62.22  E-value: 3.24e-12
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 966951040    382 WSPWSEWTSCSTSCGNGIQQRGRSCDSLNNR-----CEGSSVQTRTCHIQECD 429
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQngggpCTGEDVETRACNEQPCP 53
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 846-882 2.52e-09

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 53.52  E-value: 2.52e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 966951040   846 DSDSDRIGDTCDNnqDIDEDGHQNNLDNCPYVPNANQ 882
Cdd:pfam02412    2 DSDSDGVGDACDN--DFDNDGVPDLLDNCPNNANIDQ 36
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 439-489 4.13e-09

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 53.44  E-value: 4.13e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 966951040   439 SHWSPWSSCSVTCGDGVITRIRLCNSPsPQMNGKPCeGEARETKACKKDAC 489
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRTRTVIVE-PQNGGRPC-PELLERRPCNLPPC 52
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 496-546 7.51e-09

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 52.67  E-value: 7.51e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 966951040   496 GPWSPWDICSVTCGGGVQKRSRLCNNPtPQFGGKDCiGDVTENQICNKQDC 546
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRTRTVIVE-PQNGGRPC-PELLERRPCNLPPC 52
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 786-821 1.53e-08

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 51.21  E-value: 1.53e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 966951040   786 ADTDSNGEGDACAADIDGDGILNERDNCQYVYNVDQ 821
Cdd:pfam02412    1 TDSDSDGVGDACDNDFDNDGVPDLLDNCPNNANIDQ 36
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 919-952 5.55e-07

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 46.97  E-value: 5.55e-07
                           10        20        30
                   ....*....|....*....|....*....|....
gi 966951040   919 KDSDGDGRGDACKDDFDHDNVPDIDDICPENVDI 952
Cdd:pfam02412    1 TDSDSDGVGDACDNDFDNDGVPDLLDNCPNNANI 34
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 383-428 5.65e-07

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 47.27  E-value: 5.65e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 966951040   383 SPWSEWTSCSTSCGNGIQQR-----------GRSCDSLnnrcegssVQTRTCHIQEC 428
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRtrtvivepqngGRPCPEL--------LERRPCNLPPC 52
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 650-689 1.13e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 46.05  E-value: 1.13e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 966951040   650 CTDGTHDCNKNAKCNYlghySDPMYRCECKPGYAGNGIIC 689
Cdd:pfam12947    1 CSDNNGGCHPNATCTN----TGGSFTCTCNDGYTGDGVTC 36
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 496-546 2.25e-04

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 40.13  E-value: 2.25e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 966951040   496 GPWSPwdiCSVTCGGGVQKRSRLCNNPTPQ--FGGKDCIGDV--TENQICNKQDC 546
Cdd:pfam19030    4 GPWGE---CSVTCGGGVQTRLVQCVQKGGGsiVPDSECSAQKkpPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 443-489 1.21e-03

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 38.20  E-value: 1.21e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 966951040   443 PWSSCSVTCGDGVITRIRLCNSPSPQ--MNGKPCEGEAR--ETKACKKDAC 489
Cdd:pfam19030    5 PWGECSVTCGGGVQTRLVQCVQKGGGsiVPDSECSAQKKppETQSCNLKPC 55
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 496-517 2.47e-03

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 41.87  E-value: 2.47e-03
                          10        20
                  ....*....|....*....|..
gi 966951040  496 GPWSPWDICSVTCGGGVQKRSR 517
Cdd:PTZ00441  241 GPWDEWTPCSVTCGKGTHSRSR 262
VWC_out smart00215
von Willebrand factor (vWF) type C domain;
318-385 3.12e-03

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214565  Cd Length: 67  Bit Score: 37.16  E-value: 3.12e-03
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966951040    318 CYHNGVQYRNNEEWtVDSCTECRCQNSVTICKKVSCPIMPCSNATVpDGECCPRCWPSDSADDGWSPW 385
Cdd:smart00215    1 CWNNGSYYPPGAKW-DDDCNRCTCLNGRVSCTKVWCGPKPCLLHNL-SGECPLGQGCVPSLSDCLSSP 66
Amnionless pfam14828
Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for ...
 324-372 4.98e-03

Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for vitamin B12 uptake.


Pssm-ID: 464340  Cd Length: 449  Bit Score: 40.83  E-value: 4.98e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 966951040   324 QYRNNEEWTVDS-----CTECRCQNSVT---ICKKVS--CPIMPCSNATVPDGECCPRC 372
Cdd:pfam14828  177 QFHGAGALRVGPeacsdPSGCGCGNDENlerICANVLqrCPPPHCLSPLRPEGHCCDVC 235
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 124-217 5.79e-03

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 38.17  E-value: 5.79e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966951040   124 KAGTLDLSLTVQGKQHVVSVEEALLATGQWKSITLFVQEDRAQLYID-CEKMENAELDVPIQSVFTRDL---ASIARLRI 199
Cdd:pfam02210   26 VNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDgQTVVSSLPPGESLLLNLNGPLylgGLPPLLLL 105

                           90
                   ....*....|....*...
gi 966951040   200 AKGGVNDNFQGVLQNVRF 217
Cdd:pfam02210  106 PALPVRAGFVGCIRDVRV 123
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 692-976 6.37e-03

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 40.66  E-value: 6.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966951040  692 DTDLDGWPNEDLVCVANATYHCKKDNCPNLPNSGQEDYDKDGIGDACDDDDDNDKIPDDRDNCPFHYNPAQYDYDRDDVG 771
Cdd:NF033609  625 ASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 704

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966951040  772 DRCDNCPYNHNPDqADTDSNGEGDAcAADIDGDgilNERDNCQYVYNVDQRDTDMDGVGDQCDNCPLEHNPDQlDSDSDR 851
Cdd:NF033609  705 DSDSDSDSDSDSD-SDSDSDSDSDS-DSDSDSD---SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS-DSDSDS 778

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966951040  852 IGDTcDNNQDIDEDghqnnldncpyvpnaNQADHDKDGKGDACDHDDDNDGIPDDRDNCRLVPNPDQKDSDGDGRGDACK 931
Cdd:NF033609  779 DSDS-DSDSDSDSD---------------SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 842

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 966951040  932 D-DFDHDNVPDIDDICPENVDiSETDFRRFQMIPLDPK-GTSQNDPN 976
Cdd:NF033609  843 DsDSDSDSDSDSDSESDSNSD-SESGSNNNVVPPNSPKnGTNASNKN 888
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 124-217 9.33e-03

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 38.17  E-value: 9.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966951040  124 KAGTLDLSLTVQGKQHVVSVEEaLLATGQWKSITLFVQEDRAQLYIDCEKMENAELDVPIQSVFTRDL----ASIARLRI 199
Cdd:cd00110    54 EDGRLVLRYDLGSGSLVLSSKT-PLNDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPlylgGLPEDLKS 132

                          90
                  ....*....|....*...
gi 966951040  200 AKGGVNDNFQGVLQNVRF 217
Cdd:cd00110   133 PGLPVSPGFVGCIRDLKV 150
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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