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Conserved domains on  [gi|1622946247|ref|XP_014996046|]
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WD repeat-containing protein 36 [Macaca mulatta]

Protein Classification

WD40 and Utp21 domain-containing protein( domain architecture ID 13235296)

WD40 and Utp21 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Utp21 pfam04192
Utp21 specific WD40 associated putative domain; Utp21 is a subunit of U3 snoRNP, which is ...
 718-920 1.93e-68

Utp21 specific WD40 associated putative domain; Utp21 is a subunit of U3 snoRNP, which is essential for synthesis of 18S rRNA.


:

Pssm-ID: 461219  Cd Length: 209  Bit Score: 226.65  E-value: 1.93e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 718 EQLNEQLVTLSLLPESRWKNLLNLDVIKKKNKPKEPPKVPKSAPFFIPTIPGLVPRYAAP------EQNNDPQQSKVVNL 791
Cdd:pfam04192   1 DQLSEDLVTLSLLPRSRWQTLLHLDLIKQRNKPKEAPKKPEKAPFFLPTLGGLVGDFASVeaqeeeEEEEEEERSRLLKL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 792 GVLAQKSDFCLKLEEGLVNNKYDTALNLLKESGPSGIETELRSLspDCGGSVEVMQSFLKMIGMMLDRKRDFELAQAYLA 871
Cdd:pfam04192  81 GSLGFESEFTKLLREGSETGDYTPFLEYLKSLSPSAIDLEIRSL--NSGGPLEELVSFIRALTSRLKSNRDFELVQAYMA 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1622946247 872 LFLKLHLKMLPSEPV--LLEEITNLSSQVEENWTHLQSLFNQSMCILNYLK 920
Cdd:pfam04192 159 VFLKLHGDVIHSNEEeeLREALEEWKSVQEEEWERLDELVGYCSGVVGFLR 209
WD40 COG2319
WD40 repeat [General function prediction only];
193-665 6.01e-37

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 143.90  E-value: 6.01e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 193 ILLGSEQGSLQLWNVKSNKLLYTFPGWKLGVTALQQAPAVDVVAIGLMSGQVIIHNIKFNETLMKFRQDWGPITSISFRT 272
Cdd:COG2319     9 LAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 273 DGHPVmAAGSPCGHIGLWDLEDKKLINQMRnAHSTAIAGLTFLHREPLLVTNGADNALRIWifdgPTGEGRLLRFRMGHS 352
Cdd:COG2319    89 DGRLL-ASASADGTVRLWDLATGLLLRTLT-GHTGAVRSVAFSPDGKTLASGSADGTVRLW----DLATGKLLRTLTGHS 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 353 APLTSIRYyGQNGQQILSASQDGTlqsfstvhekfnkslghglinkkrvkrkglqntmsVRLppitkfaaeearesdWDg 432
Cdd:COG2319   163 GAVTSVAF-SPDGKLLASGSDDGT-----------------------------------VRL---------------WD- 190

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 433 iiaCHQGKLscstwnyqkstigayflkPKEMKKDDITATAVDITSCGNFAVIGLSSGTVDVYNMQSGIHRGSFgkdQAHK 512
Cdd:COG2319   191 ---LATGKL------------------LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTL---TGHS 246

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 513 GSVRGVAV--DGlnQLTVTTGSEGLLKFWNFKNKILIHSVS-LSSSPNVMLLHRDSGILGLALDDFSISVLDIETRKIVR 589
Cdd:COG2319   247 GSVRSVAFspDG--RLLASGSADGTVRLWDLATGELLRTLTgHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR 324

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622946247 590 EFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSGCLIDCFLLDSAPLN-VSMSPTGDFLATSHVDHlGIFLWS 665
Cdd:COG2319   325 TLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTsVAFSPDGRTLASGSADG-TVRLWD 400
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 122-246 1.39e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 51.18  E-value: 1.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 122 ARNKEIVHTFKGHKAEIHLLQPFGD--HIISVDTDSILIIWHIYSEEEYLQLT-FDKSVFkiSAILHPSTYLnkILLGSE 198
Cdd:cd00200   164 LRTGKCVATLTGHTGEVNSVAFSPDgeKLLSSSSDGTIKLWDLSTGKCLGTLRgHENGVN--SVAFSPDGYL--LASGSE 239

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1622946247 199 QGSLQLWNVKSNKLLYTFPGWKLGVTALQQAPAVDVVAIGLMSGQVII 246
Cdd:cd00200   240 DGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRI 287
 
Name Accession Description Interval E-value
Utp21 pfam04192
Utp21 specific WD40 associated putative domain; Utp21 is a subunit of U3 snoRNP, which is ...
 718-920 1.93e-68

Utp21 specific WD40 associated putative domain; Utp21 is a subunit of U3 snoRNP, which is essential for synthesis of 18S rRNA.


Pssm-ID: 461219  Cd Length: 209  Bit Score: 226.65  E-value: 1.93e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 718 EQLNEQLVTLSLLPESRWKNLLNLDVIKKKNKPKEPPKVPKSAPFFIPTIPGLVPRYAAP------EQNNDPQQSKVVNL 791
Cdd:pfam04192   1 DQLSEDLVTLSLLPRSRWQTLLHLDLIKQRNKPKEAPKKPEKAPFFLPTLGGLVGDFASVeaqeeeEEEEEEERSRLLKL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 792 GVLAQKSDFCLKLEEGLVNNKYDTALNLLKESGPSGIETELRSLspDCGGSVEVMQSFLKMIGMMLDRKRDFELAQAYLA 871
Cdd:pfam04192  81 GSLGFESEFTKLLREGSETGDYTPFLEYLKSLSPSAIDLEIRSL--NSGGPLEELVSFIRALTSRLKSNRDFELVQAYMA 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1622946247 872 LFLKLHLKMLPSEPV--LLEEITNLSSQVEENWTHLQSLFNQSMCILNYLK 920
Cdd:pfam04192 159 VFLKLHGDVIHSNEEeeLREALEEWKSVQEEEWERLDELVGYCSGVVGFLR 209
WD40 COG2319
WD40 repeat [General function prediction only];
193-665 6.01e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 143.90  E-value: 6.01e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 193 ILLGSEQGSLQLWNVKSNKLLYTFPGWKLGVTALQQAPAVDVVAIGLMSGQVIIHNIKFNETLMKFRQDWGPITSISFRT 272
Cdd:COG2319     9 LAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 273 DGHPVmAAGSPCGHIGLWDLEDKKLINQMRnAHSTAIAGLTFLHREPLLVTNGADNALRIWifdgPTGEGRLLRFRMGHS 352
Cdd:COG2319    89 DGRLL-ASASADGTVRLWDLATGLLLRTLT-GHTGAVRSVAFSPDGKTLASGSADGTVRLW----DLATGKLLRTLTGHS 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 353 APLTSIRYyGQNGQQILSASQDGTlqsfstvhekfnkslghglinkkrvkrkglqntmsVRLppitkfaaeearesdWDg 432
Cdd:COG2319   163 GAVTSVAF-SPDGKLLASGSDDGT-----------------------------------VRL---------------WD- 190

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 433 iiaCHQGKLscstwnyqkstigayflkPKEMKKDDITATAVDITSCGNFAVIGLSSGTVDVYNMQSGIHRGSFgkdQAHK 512
Cdd:COG2319   191 ---LATGKL------------------LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTL---TGHS 246

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 513 GSVRGVAV--DGlnQLTVTTGSEGLLKFWNFKNKILIHSVS-LSSSPNVMLLHRDSGILGLALDDFSISVLDIETRKIVR 589
Cdd:COG2319   247 GSVRSVAFspDG--RLLASGSADGTVRLWDLATGELLRTLTgHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR 324

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622946247 590 EFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSGCLIDCFLLDSAPLN-VSMSPTGDFLATSHVDHlGIFLWS 665
Cdd:COG2319   325 TLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTsVAFSPDGRTLASGSADG-TVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 305-623 1.30e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 122.44  E-value: 1.30e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 305 HSTAIAGLTFLHREPLLVTNGADNALRIWIFDGptgeGRLLRFRMGHSAPLTSIRYYGqNGQQILSASQDGTLQSFSTVH 384
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLET----GELLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTIRLWDLET 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 385 EKFNKSL-GHglinKKRVkrkglqntMSVRLPPITKFAAEeareSDWDGIIAChqgklscstWNyqksTIGAYFLKPKEM 463
Cdd:cd00200    83 GECVRTLtGH----TSYV--------SSVAFSPDGRILSS----SSRDKTIKV---------WD----VETGKCLTTLRG 133

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 464 KKDDITAtaVDITSCGNFAVIGLSSGTVDVYNMQSGIHRGSFgkdQAHKGSVRGVAVDGLNQLTVTTGSEGLLKFWNFKN 543
Cdd:cd00200   134 HTDWVNS--VAFSPDGTFVASSSQDGTIKLWDLRTGKCVATL---TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST 208

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 544 KILIHSVSLSSSP-NVMLLHRDSGILGLALDDFSISVLDIETRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTW 622
Cdd:cd00200   209 GKCLGTLRGHENGvNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288


                  .
gi 1622946247 623 D 623
Cdd:cd00200   289 D 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 584-623 1.04e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 54.63  E-value: 1.04e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1622946247  584 TRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWD 623
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
585-623 2.39e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 53.50  E-value: 2.39e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1622946247 585 RKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWD 623
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 122-246 1.39e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 51.18  E-value: 1.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 122 ARNKEIVHTFKGHKAEIHLLQPFGD--HIISVDTDSILIIWHIYSEEEYLQLT-FDKSVFkiSAILHPSTYLnkILLGSE 198
Cdd:cd00200   164 LRTGKCVATLTGHTGEVNSVAFSPDgeKLLSSSSDGTIKLWDLSTGKCLGTLRgHENGVN--SVAFSPDGYL--LASGSE 239

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1622946247 199 QGSLQLWNVKSNKLLYTFPGWKLGVTALQQAPAVDVVAIGLMSGQVII 246
Cdd:cd00200   240 DGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRI 287
PQQ_ABC_repeats TIGR03866
PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family ...
 546-654 7.58e-05

PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family consist of seven repeats each of the YVTN family beta-propeller repeat (see TIGR02276). Members occur invariably as part of a transport operon that is associated with PQQ-dependent catabolism of alcohols such as phenylethanol.


Pssm-ID: 274824 [Multi-domain]  Cd Length: 310  Bit Score: 45.80  E-value: 7.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 546 LIHSVSLSSSPNVMLLHRDSGILGLA-LDDFSISVLDIETRKIVrefsghqGQIN------DMAFSPDGRWLISAAMDCS 618
Cdd:TIGR03866  75 VLHTLPSGPDPEQFALHPNGKILYIAnEDDALVTVIDIETRKVL-------AQIDvgvepeGMAVSPDGKIVVNTSETTN 147

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1622946247 619 IRTW-DLPSGCLIDCFLLDSAPLNVSMSPTGDFLATS 654
Cdd:TIGR03866 148 MAHWiDTATYEIVDNTLVDARPRFAEFTADGKELWVS 184
 
Name Accession Description Interval E-value
Utp21 pfam04192
Utp21 specific WD40 associated putative domain; Utp21 is a subunit of U3 snoRNP, which is ...
 718-920 1.93e-68

Utp21 specific WD40 associated putative domain; Utp21 is a subunit of U3 snoRNP, which is essential for synthesis of 18S rRNA.


Pssm-ID: 461219  Cd Length: 209  Bit Score: 226.65  E-value: 1.93e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 718 EQLNEQLVTLSLLPESRWKNLLNLDVIKKKNKPKEPPKVPKSAPFFIPTIPGLVPRYAAP------EQNNDPQQSKVVNL 791
Cdd:pfam04192   1 DQLSEDLVTLSLLPRSRWQTLLHLDLIKQRNKPKEAPKKPEKAPFFLPTLGGLVGDFASVeaqeeeEEEEEEERSRLLKL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 792 GVLAQKSDFCLKLEEGLVNNKYDTALNLLKESGPSGIETELRSLspDCGGSVEVMQSFLKMIGMMLDRKRDFELAQAYLA 871
Cdd:pfam04192  81 GSLGFESEFTKLLREGSETGDYTPFLEYLKSLSPSAIDLEIRSL--NSGGPLEELVSFIRALTSRLKSNRDFELVQAYMA 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1622946247 872 LFLKLHLKMLPSEPV--LLEEITNLSSQVEENWTHLQSLFNQSMCILNYLK 920
Cdd:pfam04192 159 VFLKLHGDVIHSNEEeeLREALEEWKSVQEEEWERLDELVGYCSGVVGFLR 209
WD40 COG2319
WD40 repeat [General function prediction only];
193-665 6.01e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 143.90  E-value: 6.01e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 193 ILLGSEQGSLQLWNVKSNKLLYTFPGWKLGVTALQQAPAVDVVAIGLMSGQVIIHNIKFNETLMKFRQDWGPITSISFRT 272
Cdd:COG2319     9 LAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 273 DGHPVmAAGSPCGHIGLWDLEDKKLINQMRnAHSTAIAGLTFLHREPLLVTNGADNALRIWifdgPTGEGRLLRFRMGHS 352
Cdd:COG2319    89 DGRLL-ASASADGTVRLWDLATGLLLRTLT-GHTGAVRSVAFSPDGKTLASGSADGTVRLW----DLATGKLLRTLTGHS 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 353 APLTSIRYyGQNGQQILSASQDGTlqsfstvhekfnkslghglinkkrvkrkglqntmsVRLppitkfaaeearesdWDg 432
Cdd:COG2319   163 GAVTSVAF-SPDGKLLASGSDDGT-----------------------------------VRL---------------WD- 190

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 433 iiaCHQGKLscstwnyqkstigayflkPKEMKKDDITATAVDITSCGNFAVIGLSSGTVDVYNMQSGIHRGSFgkdQAHK 512
Cdd:COG2319   191 ---LATGKL------------------LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTL---TGHS 246

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 513 GSVRGVAV--DGlnQLTVTTGSEGLLKFWNFKNKILIHSVS-LSSSPNVMLLHRDSGILGLALDDFSISVLDIETRKIVR 589
Cdd:COG2319   247 GSVRSVAFspDG--RLLASGSADGTVRLWDLATGELLRTLTgHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR 324

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622946247 590 EFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSGCLIDCFLLDSAPLN-VSMSPTGDFLATSHVDHlGIFLWS 665
Cdd:COG2319   325 TLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTsVAFSPDGRTLASGSADG-TVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
193-626 2.74e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 141.97  E-value: 2.74e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 193 ILLGSEQGSLQLWNVKSNKLLYTFPGWKLGVTALQQAPAVDVVAIGLMSGQVIIHNIKFNETLMKFRQDWGPITSISFRT 272
Cdd:COG2319    51 LAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 273 DGHPVMAAGSPcGHIGLWDLEDKKLINQMRnAHSTAIAGLTFLHREPLLVTNGADNALRIWifDGPTGegRLLRFRMGHS 352
Cdd:COG2319   131 DGKTLASGSAD-GTVRLWDLATGKLLRTLT-GHSGAVTSVAFSPDGKLLASGSDDGTVRLW--DLATG--KLLRTLTGHT 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 353 APLTSIRYyGQNGQQILSASQDGTlqsfstvhekfnkslghglinkkrvkrkglqntmsVRLppitkfaaeearesdWDg 432
Cdd:COG2319   205 GAVRSVAF-SPDGKLLASGSADGT-----------------------------------VRL---------------WD- 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 433 iiaCHQGKLscstwnyqkstigayflkPKEMKKDDITATAVDITSCGNFAVIGLSSGTVDVYNMQSGIHRGSFGkdqAHK 512
Cdd:COG2319   233 ---LATGKL------------------LRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT---GHS 288

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 513 GSVRGVAV--DGlnQLTVTTGSEGLLKFWNFKNKILIHSVSLSSSPNVML-LHRDSGILGLALDDFSISVLDIETRKIVR 589
Cdd:COG2319   289 GGVNSVAFspDG--KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVaFSPDGKTLASGSDDGTVRLWDLATGELLR 366

                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 1622946247 590 EFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPS 626
Cdd:COG2319   367 TLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 305-623 1.30e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 122.44  E-value: 1.30e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 305 HSTAIAGLTFLHREPLLVTNGADNALRIWIFDGptgeGRLLRFRMGHSAPLTSIRYYGqNGQQILSASQDGTLQSFSTVH 384
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLET----GELLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTIRLWDLET 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 385 EKFNKSL-GHglinKKRVkrkglqntMSVRLPPITKFAAEeareSDWDGIIAChqgklscstWNyqksTIGAYFLKPKEM 463
Cdd:cd00200    83 GECVRTLtGH----TSYV--------SSVAFSPDGRILSS----SSRDKTIKV---------WD----VETGKCLTTLRG 133

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 464 KKDDITAtaVDITSCGNFAVIGLSSGTVDVYNMQSGIHRGSFgkdQAHKGSVRGVAVDGLNQLTVTTGSEGLLKFWNFKN 543
Cdd:cd00200   134 HTDWVNS--VAFSPDGTFVASSSQDGTIKLWDLRTGKCVATL---TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST 208

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 544 KILIHSVSLSSSP-NVMLLHRDSGILGLALDDFSISVLDIETRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTW 622
Cdd:cd00200   209 GKCLGTLRGHENGvNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288


                  .
gi 1622946247 623 D 623
Cdd:cd00200   289 D 289
WD40 COG2319
WD40 repeat [General function prediction only];
22-378 1.00e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 110.77  E-value: 1.00e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247  22 SGAGIAAAMERASERRTASALFAGFRALGLFSNDIPHVVRFSALKRRFyVTTCVGKSFHTYDVQKLSLVAVSNSVPQDIC 101
Cdd:COG2319    46 PDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLL-ASASADGTVRLWDLATGLLLRTLTGHTGAVR 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 102 CMA--ADGRLVFAAYGN----VFSAfaRNKEIVHTFKGHKAEIHLLQ--PFGDHIISVDTDSILIIWHIYSEEEYLQLT- 172
Cdd:COG2319   125 SVAfsPDGKTLASGSADgtvrLWDL--ATGKLLRTLTGHSGAVTSVAfsPDGKLLASGSDDGTVRLWDLATGKLLRTLTg 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 173 FDKSVFkiSAILHPStylNKILL-GSEQGSLQLWNVKSNKLLYTFPGWKLGVTALQQAPAVDVVAIGLMSGQVIIHNIKF 251
Cdd:COG2319   203 HTGAVR--SVAFSPD---GKLLAsGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAT 277

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 252 NETLMKFRQDWGPITSISFRTDGHPVMAAGSPcGHIGLWDLEDKKLINQMRnAHSTAIAGLTFLHREPLLVTNGADNALR 331
Cdd:COG2319   278 GELLRTLTGHSGGVNSVAFSPDGKLLASGSDD-GTVRLWDLATGKLLRTLT-GHTGAVRSVAFSPDGKTLASGSDDGTVR 355

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 1622946247 332 IWIFDGptgeGRLLRFRMGHSAPLTSIRYyGQNGQQILSASQDGTLQ 378
Cdd:COG2319   356 LWDLAT----GELLRTLTGHTGAVTSVAF-SPDGRTLASGSADGTVR 397
WD40 COG2319
WD40 repeat [General function prediction only];
471-690 1.39e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 110.39  E-value: 1.39e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 471 TAVDITSCGNFAVIGLSSGTVDVYNMQSGIHRGSFgkdQAHKGSVRGVAV--DGlnQLTVTTGSEGLLKFWNFKNKILIH 548
Cdd:COG2319   124 RSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL---TGHSGAVTSVAFspDG--KLLASGSDDGTVRLWDLATGKLLR 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 549 SV--------SLSSSPnvmllhrDSGILGLALDDFSISVLDIETRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIR 620
Cdd:COG2319   199 TLtghtgavrSVAFSP-------DGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVR 271

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622946247 621 TWDLPSGCLIDCFLLDSAPLN-VSMSPTGDFLATSHVDHlGIFLWsNISLYSVVSLRPLPADYVPSVVMLP 690
Cdd:COG2319   272 LWDLATGELLRTLTGHSGGVNsVAFSPDGKLLASGSDDG-TVRLW-DLATGKLLRTLTGHTGAVRSVAFSP 340
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 128-393 3.68e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 106.65  E-value: 3.68e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 128 VHTFKGHKAEIHLLQ--PFGDHIISVDTDSILIIWHIYSEEEYLQLT-FDKSVFKISAILHpstyLNKILLGSEQGSLQL 204
Cdd:cd00200     2 RRTLKGHTGGVTCVAfsPDGKLLATGSGDGTIKVWDLETGELLRTLKgHTGPVRDVAASAD----GTYLASGSSDKTIRL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 205 WNVKSNKLLYTFPGWKLGVTALQQAPAVDVVAIGLMSGQVIIHNIKFNETLMKFRQDWGPITSISFRTDGHpVMAAGSPC 284
Cdd:cd00200    78 WDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGT-FVASSSQD 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 285 GHIGLWDLEDKKLINQMRnAHSTAIAGLTFLHREPLLVTNGADNALRIWIFDgptgEGRLLRFRMGHSAPLTSIRyYGQN 364
Cdd:cd00200   157 GTIKLWDLRTGKCVATLT-GHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS----TGKCLGTLRGHENGVNSVA-FSPD 230

                         250       260       270
                  ....*....|....*....|....*....|
gi 1622946247 365 GQQILSASQDGTLQSFSTVHEKFNKSL-GH 393
Cdd:cd00200   231 GYLLASGSEDGTIRVWDLRTGECVQTLsGH 260
WD40 COG2319
WD40 repeat [General function prediction only];
479-690 1.02e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 101.53  E-value: 1.02e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 479 GNFAVIGLSSGTVDVYNMQSGIHRGSFgkdQAHKGSVRGVAVDGLNQLTVTTGSEGLLKFWNFKNKILIHSVS-LSSSPN 557
Cdd:COG2319    48 GARLAAGAGDLTLLLLDAAAGALLATL---LGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTgHTGAVR 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 558 VMLLHRDSGILGLALDDFSISVLDIETRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSGCLIDCFLLDS 637
Cdd:COG2319   125 SVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHT 204

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1622946247 638 APLN-VSMSPTGDFLATSHVDHlGIFLWsNISLYSVVSLRPLPADYVPSVVMLP 690
Cdd:COG2319   205 GAVRsVAFSPDGKLLASGSADG-TVRLW-DLATGKLLRTLTGHSGSVRSVAFSP 256
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 100-377 3.42e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 97.79  E-value: 3.42e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 100 ICCMA--ADGRLVFAAYGN----VFSAFarNKEIVHTFKGHKAEIHLLQ--PFGDHIISVDTDSILIIWHIYSEEEYLQL 171
Cdd:cd00200    12 VTCVAfsPDGKLLATGSGDgtikVWDLE--TGELLRTLKGHTGPVRDVAasADGTYLASGSSDKTIRLWDLETGECVRTL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 172 T-FDKSVFKISaiLHPSTYLnkILLGSEQGSLQLWNVKSNKLLYTFPGWKLGVTALQQAPAVDVVAIGLMSGQVIIHNIK 250
Cdd:cd00200    90 TgHTSYVSSVA--FSPDGRI--LSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLR 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 251 FNETLMKFRQDWGPITSISFRTDGHPVMAAGSPcGHIGLWDLEDKKLINQMRnAHSTAIAGLTFLHREPLLVTNGADNAL 330
Cdd:cd00200   166 TGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSD-GTIKLWDLSTGKCLGTLR-GHENGVNSVAFSPDGYLLASGSEDGTI 243

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1622946247 331 RIWifDGPTGEgRLLRFRmGHSAPLTSIRYYGqNGQQILSASQDGTL 377
Cdd:cd00200   244 RVW--DLRTGE-CVQTLS-GHTNSVTSLAWSP-DGKRLASGSADGTI 285
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 509-665 3.03e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.01  E-value: 3.03e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 509 QAHKGSVRGVAVDGLNQLTVTTGSEGLLKFWNFKNKILIHS-VSLSSSPNVMLLHRDSGILGLALDDFSISVLDIETRKI 587
Cdd:cd00200     6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTlKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC 85

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622946247 588 VREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSGCLIDCFLLDSAPLN-VSMSPTGDFLATSHVDHLgIFLWS 665
Cdd:cd00200    86 VRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNsVAFSPDGTFVASSSQDGT-IKLWD 163
WD40 COG2319
WD40 repeat [General function prediction only];
60-333 1.80e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.90  E-value: 1.80e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247  60 VRFSALKRRFyVTTCVGKSFHTYDVQKLSLVAVSNSVPQDICCMA--ADGRLVFAAYGN----VFSAfaRNKEIVHTFKG 133
Cdd:COG2319   126 VAFSPDGKTL-ASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAfsPDGKLLASGSDDgtvrLWDL--ATGKLLRTLTG 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 134 HKAEIHLLQ--PFGDHIISVDTDSILIIWHIYSEEeyLQLTFDKSVFKISAI-LHPStylNKILL-GSEQGSLQLWNVKS 209
Cdd:COG2319   203 HTGAVRSVAfsPDGKLLASGSADGTVRLWDLATGK--LLRTLTGHSGSVRSVaFSPD---GRLLAsGSADGTVRLWDLAT 277

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 210 NKLLYTFPGWKLGVTALQQAPAVDVVAIGLMSGQVIIHNIKFNETLMKFRQDWGPITSISFRTDGHPVmAAGSPCGHIGL 289
Cdd:COG2319   278 GELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTL-ASGSDDGTVRL 356

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1622946247 290 WDLEDKKLINQMRnAHSTAIAGLTFLHREPLLVTNGADNALRIW 333
Cdd:COG2319   357 WDLATGELLRTLT-GHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 471-678 2.83e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 89.32  E-value: 2.83e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 471 TAVDITSCGNFAVIGLSSGTVDVYNMQSGIHRGSFgkdQAHKGSVRGVAVDGLNQLTVTTGSEGLLKFWNFKNKILIH-- 548
Cdd:cd00200    13 TCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL---KGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRtl 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 549 --------SVSLSSSPNVML---------------------------------LHRDSGILGLALDDFSISVLDIETRKI 587
Cdd:cd00200    90 tghtsyvsSVAFSPDGRILSsssrdktikvwdvetgkclttlrghtdwvnsvaFSPDGTFVASSSQDGTIKLWDLRTGKC 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 588 VREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSGCLIDCFLLDSAPLN-VSMSPTGDFLATSHVDhlgiflwSN 666
Cdd:cd00200   170 VATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNsVAFSPDGYLLASGSED-------GT 242

                         250
                  ....*....|..
gi 1622946247 667 ISLYSVVSLRPL 678
Cdd:cd00200   243 IRVWDLRTGECV 254
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 123-333 8.47e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 73.14  E-value: 8.47e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 123 RNKEIVHTFKGHKAEIH--LLQPFGDHIISVDTDSILIIWHIysEEEYLQLTFD---KSVFKISaiLHPStylNKILLGS 197
Cdd:cd00200    81 ETGECVRTLTGHTSYVSsvAFSPDGRILSSSSRDKTIKVWDV--ETGKCLTTLRghtDWVNSVA--FSPD---GTFVASS 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 198 EQ-GSLQLWNVKSNKLLYTFPGWKLGVTALQQAPAVDVVAIGLMSGQVIIHNIKFNETLMKFRQDWGPITSISFRTDGHp 276
Cdd:cd00200   154 SQdGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGY- 232

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622946247 277 VMAAGSPCGHIGLWDLEDKKLINQMRnAHSTAIAGLTFLHREPLLVTNGADNALRIW 333
Cdd:cd00200   233 LLASGSEDGTIRVWDLRTGECVQTLS-GHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 588-665 3.58e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 61.97  E-value: 3.58e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622946247 588 VREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSGCLIDCFLLDSAPLN-VSMSPTGDFLATSHVDHLgIFLWS 665
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRdVAASADGTYLASGSSDKT-IRLWD 79
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 561-690 6.25e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 61.20  E-value: 6.25e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 561 LHRDSGILGLALDDFSISVLDIETRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSGCLIDCFLLDSAPL 640
Cdd:cd00200    17 FSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYV 96

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1622946247 641 N-VSMSPTGDFLATSHVDHlGIFLWSNISLYSVVSLRPlPADYVPSVVMLP 690
Cdd:cd00200    97 SsVAFSPDGRILSSSSRDK-TIKVWDVETGKCLTTLRG-HTDWVNSVAFSP 145
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 584-623 1.04e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 54.63  E-value: 1.04e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1622946247  584 TRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWD 623
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
585-623 2.39e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 53.50  E-value: 2.39e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1622946247 585 RKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWD 623
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
468-651 2.35e-08

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 55.86  E-value: 2.35e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 468 ITATAVDITSCGNFAVIGLSSGTVDVYNMQSGIHRGSFGKDQAHKGSVRGVAVDGlNQLTVTTGSEGLLKFWNFKNKILI 547
Cdd:COG3391    25 VAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADG-RRLYVANSGSGRVSVIDLATGKVV 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 548 HSVSLSSSPNVMLLHRDSGILGLA-LDDFSISVLDIETRKIVREFSGHqGQINDMAFSPDGRWLISAAMDCS-----IRT 621
Cdd:COG3391   104 ATIPVGGGPRGLAVDPDGGRLYVAdSGNGRVSVIDTATGKVVATIPVG-AGPHGIAVDPDGKRLYVANSGSNtvsviVSV 182

                         170       180       190
                  ....*....|....*....|....*....|
gi 1622946247 622 WDLPSGCLIDCFLLDSAPLNVSMSPTGDFL 651
Cdd:COG3391   183 IDTATGKVVATIPVGGGPVGVAVSPDGRRL 212
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 122-246 1.39e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 51.18  E-value: 1.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 122 ARNKEIVHTFKGHKAEIHLLQPFGD--HIISVDTDSILIIWHIYSEEEYLQLT-FDKSVFkiSAILHPSTYLnkILLGSE 198
Cdd:cd00200   164 LRTGKCVATLTGHTGEVNSVAFSPDgeKLLSSSSDGTIKLWDLSTGKCLGTLRgHENGVN--SVAFSPDGYL--LASGSE 239

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1622946247 199 QGSLQLWNVKSNKLLYTFPGWKLGVTALQQAPAVDVVAIGLMSGQVII 246
Cdd:cd00200   240 DGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRI 287
PQQ_ABC_repeats TIGR03866
PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family ...
 546-654 7.58e-05

PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family consist of seven repeats each of the YVTN family beta-propeller repeat (see TIGR02276). Members occur invariably as part of a transport operon that is associated with PQQ-dependent catabolism of alcohols such as phenylethanol.


Pssm-ID: 274824 [Multi-domain]  Cd Length: 310  Bit Score: 45.80  E-value: 7.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 546 LIHSVSLSSSPNVMLLHRDSGILGLA-LDDFSISVLDIETRKIVrefsghqGQIN------DMAFSPDGRWLISAAMDCS 618
Cdd:TIGR03866  75 VLHTLPSGPDPEQFALHPNGKILYIAnEDDALVTVIDIETRKVL-------AQIDvgvepeGMAVSPDGKIVVNTSETTN 147

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1622946247 619 IRTW-DLPSGCLIDCFLLDSAPLNVSMSPTGDFLATS 654
Cdd:TIGR03866 148 MAHWiDTATYEIVDNTLVDARPRFAEFTADGKELWVS 184
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 230-314 7.41e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 39.57  E-value: 7.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946247 230 PAVDVVAIGLMSGQVIIHNIKFNE--TLMKFRQDwGPITSISFRTDGHpVMAAGSPCGHIGLWDLEDKKLINQmRNAHST 307
Cdd:pfam12894   5 PTMDLIALATEDGELLLHRLNWQRvwTLSPDKED-LEVTSLAWRPDGK-LLAVGYSDGTVRLLDAENGKIVHH-FSAGSD 81


                  ....*..
gi 1622946247 308 AIAGLTF 314
Cdd:pfam12894  82 LITCLGW 88
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 573-610 2.35e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 41.95  E-value: 2.35e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1622946247  573 DDFSISVLDIET---RKIVRefSGHQGQINDMAFSPDGRWL 610
Cdd:COG4946    408 NRGRLWVVDLASgkvRKVDT--DGYGDGISDLAWSPDSKWL 446
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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