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Conserved domains on  [gi|1622945228|ref|XP_014995769|]
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DNA polymerase kappa isoform X1 [Macaca mulatta]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PolY_Pol_IV_kappa cd03586
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ...
 104-516 8.95e-149

DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.


:

Pssm-ID: 176459 [Multi-domain]  Cd Length: 334  Bit Score: 441.19  E-value: 8.95e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 104 VHIDMDAFYAAVEMRDNPELKDKPIAVGSMS---MLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKE 180
Cdd:cd03586     1 IHIDMDAFYASVEQRDNPELKGKPVAVGGSSdrgVVSTASYEARKFGVRSAMPIFQAKKLCPNLIFVPPRFDKYREVSRQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 181 VKEILADYDPNFMAMSLDEAYLNITKHLeerqnwpedkrkyfikmgnsvendnpgkevnklsdhersispllfeespsdl 260
Cdd:cd03586    81 IMEILREYTPLVEPLSIDEAYLDVTDYV---------------------------------------------------- 108

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 261 lppgdpfqvnfeeqnspqilqnsiVFGTSAEEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPnrQ 340
Cdd:cd03586   109 ------------------------RLFGSATEIAKEIRARIREETGLTASAGIAPNKFLAKIASDLNKPNGLTVIPP--E 162

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 341 AVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQRALLSLLFSETSWHYFLHISLGLGSTYLTRDGERKSMSVER 420
Cdd:cd03586   163 DVEEFLAPLPVRKIPGVGKVTAEKLKELGIKTIGDLAKLDVELLKKLFGKSGRRLYELARGIDNRPVEPDRERKSIGVER 242

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 421 TFSE-INKAEEQYSLCEELCSELARDLQKEGLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKELLKTEIDad 499
Cdd:cd03586   243 TFSEdLTDPEELLEELLELAEELAERLRKRGLKGRTVTVKLKYADFSTRTRSRTLPEPTDDAEDIYELALELLEELLD-- 320

                         410
                  ....*....|....*..
gi 1622945228 500 fphPLRLRLMGVRISSF 516
Cdd:cd03586   321 ---GRPIRLLGVRLSGL 334
ZnF_Rad18 super family cl42863
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ...
 777-803 2.64e-04

Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.


The actual alignment was detected with superfamily member smart00734:

Pssm-ID: 128973 [Multi-domain]  Cd Length: 24  Bit Score: 38.74  E-value: 2.64e-04
                           10        20
                   ....*....|....*....|....*..
gi 1622945228  777 ALVCPVCNVEQKtsdLTLFNVHVDVCL 803
Cdd:smart00734   1 LVQCPVCFREVP---ENLINSHLDSCL 24
ZnF_Rad18 super family cl42863
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ...
 621-647 4.71e-04

Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.


The actual alignment was detected with superfamily member smart00734:

Pssm-ID: 128973 [Multi-domain]  Cd Length: 24  Bit Score: 37.97  E-value: 4.71e-04
                           10        20
                   ....*....|....*....|....*..
gi 1622945228  621 IFTCPVCFRAQgciSLEAFNKHVDACL 647
Cdd:smart00734   1 LVQCPVCFREV---PENLINSHLDSCL 24
 
Name Accession Description Interval E-value
PolY_Pol_IV_kappa cd03586
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ...
 104-516 8.95e-149

DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.


Pssm-ID: 176459 [Multi-domain]  Cd Length: 334  Bit Score: 441.19  E-value: 8.95e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 104 VHIDMDAFYAAVEMRDNPELKDKPIAVGSMS---MLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKE 180
Cdd:cd03586     1 IHIDMDAFYASVEQRDNPELKGKPVAVGGSSdrgVVSTASYEARKFGVRSAMPIFQAKKLCPNLIFVPPRFDKYREVSRQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 181 VKEILADYDPNFMAMSLDEAYLNITKHLeerqnwpedkrkyfikmgnsvendnpgkevnklsdhersispllfeespsdl 260
Cdd:cd03586    81 IMEILREYTPLVEPLSIDEAYLDVTDYV---------------------------------------------------- 108

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 261 lppgdpfqvnfeeqnspqilqnsiVFGTSAEEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPnrQ 340
Cdd:cd03586   109 ------------------------RLFGSATEIAKEIRARIREETGLTASAGIAPNKFLAKIASDLNKPNGLTVIPP--E 162

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 341 AVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQRALLSLLFSETSWHYFLHISLGLGSTYLTRDGERKSMSVER 420
Cdd:cd03586   163 DVEEFLAPLPVRKIPGVGKVTAEKLKELGIKTIGDLAKLDVELLKKLFGKSGRRLYELARGIDNRPVEPDRERKSIGVER 242

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 421 TFSE-INKAEEQYSLCEELCSELARDLQKEGLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKELLKTEIDad 499
Cdd:cd03586   243 TFSEdLTDPEELLEELLELAEELAERLRKRGLKGRTVTVKLKYADFSTRTRSRTLPEPTDDAEDIYELALELLEELLD-- 320

                         410
                  ....*....|....*..
gi 1622945228 500 fphPLRLRLMGVRISSF 516
Cdd:cd03586   321 ---GRPIRLLGVRLSGL 334
PRK02406 PRK02406
DNA polymerase IV; Validated
 108-522 1.52e-100

DNA polymerase IV; Validated


Pssm-ID: 235035 [Multi-domain]  Cd Length: 343  Bit Score: 316.29  E-value: 1.52e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 108 MDAFYAAVEMRDNPELKDKPIAVGS----MSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEVKE 183
Cdd:PRK02406    1 MDCFYAAVEMRDNPELRGKPVAVGGspgrRGVISTCNYEARKFGVRSAMPTAQALKLCPDLIFVPGRFDVYKEVSRQIRE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 184 ILADYDPNFMAMSLDEAYLNITkhleerqnwpedkrkyfikmgnsvenDNPgkevnklsdhersispllfeespsdllpp 263
Cdd:PRK02406   81 IFRRYTDLIEPLSLDEAYLDVT--------------------------DNK----------------------------- 105

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 264 gdpfqvnfeeQNSPqilqnsivfgtSAEEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPNRqaVM 343
Cdd:PRK02406  106 ----------LCIG-----------SATLIAQEIRQDIFEELGLTASAGVAPNKFLAKIASDWNKPNGLFVITPEE--VD 162

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 344 DFIKDLPIRKVSGIGKVTEKMLKALGIITCTELyQQRALLSLL-----FSetswHYFLHISLGLGSTYLTRDGERKSMSV 418
Cdd:PRK02406  163 AFLATLPVEKIPGVGKVTAEKLHALGIYTCADL-QKYDLAELIrhfgkFG----RRLYERARGIDERPVKPDRERKSVGV 237

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 419 ERTFSE-INKAEEQYSLCEELCSELARDLQKEG--LKGRTVTIKLKNVNFEVKTRaSTVSSVVSTAEEIFAIAKELLKTE 495
Cdd:PRK02406  238 ERTFAEdLYDLEACLAELPRLAEKLERRLERAKpdKRIKTVGVKLKFADFQQTTK-EHTADPLDKADLIELLAQALLRRL 316

                         410       420
                  ....*....|....*....|....*..
gi 1622945228 496 idadfpHPLRLRLMGVRISSFPNEEDR 522
Cdd:PRK02406  317 ------GGRGVRLLGVGVTLLEPQLER 337
DinP COG0389
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ...
 102-514 3.34e-97

Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];


Pssm-ID: 440158 [Multi-domain]  Cd Length: 336  Bit Score: 307.46  E-value: 3.34e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 102 TIVHIDMDAFYAAVEMRDNPELKDKPIAVGSMSM---LSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVS 178
Cdd:COG0389     2 RILHVDMDAFYASVEQRDRPELRGKPVAVGGDNNrgvVAAASYEARAFGVRSGMPLFQARRLCPDLVVLPPDFELYRDVS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 179 KEVKEILADYDPNFMAMSLDEAYLNITKhleerqnwpedkrkyfikmgnsvendnpgkevnklsdhersiSPLLFEesps 258
Cdd:COG0389    82 RRVMAILERYTPLVEPLSIDEAFLDVTG------------------------------------------SARLFG---- 115

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 259 dllppgdpfqvnfeeqnspqilqnsivfgtSAEEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPN 338
Cdd:COG0389   116 ------------------------------SAEAIARRIRRRIRRETGLTVSVGIAPNKFLAKIASDLAKPDGLTVIPPG 165

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 339 RQAvmDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQ-RALLSLLFSEtSWHYFLHISLGLGSTYLTRDGERKSMS 417
Cdd:COG0389   166 EVA--AFLAPLPVEKLWGVGPKTAEKLARLGIRTIGDLAALpRAELRRRFGK-VGERLYRLARGIDPRPVEPRRPRKSIG 242

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 418 VERTFSE-INKAEEQYSLCEELCSELARDLQKEGLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKELLktei 496
Cdd:COG0389   243 VERTFGEdLTDLEELEAALRRLAERLAERLRRQGLGARTVTVKLRTSDFRTTTRSRTLPEPTDDTAELLRAARELL---- 318

                         410
                  ....*....|....*...
gi 1622945228 497 DADFPHPLRLRLMGVRIS 514
Cdd:COG0389   319 ERIYRPGRPVRLLGVRLS 336
IMS pfam00817
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
 106-325 2.39e-46

impB/mucB/samB family; These proteins are involved in UV protection (Swiss).


Pssm-ID: 425885 [Multi-domain]  Cd Length: 148  Bit Score: 162.36  E-value: 2.39e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 106 IDMDAFYAAVEMRDNPELKDKPIAVGS---MSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEVK 182
Cdd:pfam00817   1 IDMDAFFASVELLRDPELKGKPVAVGGgngRGIVAAASYEARKYGVRSGMPVFEAKKLCPNLIVVPPDLELYRRASRKIF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 183 EILADY-DPNFMAMSLDEAYLNITKHLEerqnwpedkrkyfikmgnsvendnpgkevnklsdhersisplLFEespsdll 261
Cdd:pfam00817  81 EILRRFsTPKVEQASIDEAFLDLTGLEK------------------------------------------LFG------- 111

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622945228 262 ppgdpfqvnfeeqnspqilqnsivfgtSAEEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSD 325
Cdd:pfam00817 112 ---------------------------AEEALAKRLRREIAEETGLTCSIGIAPNKLLAKLASD 148
ZnF_Rad18 smart00734
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ...
 777-803 2.64e-04

Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.


Pssm-ID: 128973 [Multi-domain]  Cd Length: 24  Bit Score: 38.74  E-value: 2.64e-04
                           10        20
                   ....*....|....*....|....*..
gi 1622945228  777 ALVCPVCNVEQKtsdLTLFNVHVDVCL 803
Cdd:smart00734   1 LVQCPVCFREVP---ENLINSHLDSCL 24
ZnF_Rad18 smart00734
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ...
 621-647 4.71e-04

Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.


Pssm-ID: 128973 [Multi-domain]  Cd Length: 24  Bit Score: 37.97  E-value: 4.71e-04
                           10        20
                   ....*....|....*....|....*..
gi 1622945228  621 IFTCPVCFRAQgciSLEAFNKHVDACL 647
Cdd:smart00734   1 LVQCPVCFREV---PENLINSHLDSCL 24
 
Name Accession Description Interval E-value
PolY_Pol_IV_kappa cd03586
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ...
 104-516 8.95e-149

DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.


Pssm-ID: 176459 [Multi-domain]  Cd Length: 334  Bit Score: 441.19  E-value: 8.95e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 104 VHIDMDAFYAAVEMRDNPELKDKPIAVGSMS---MLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKE 180
Cdd:cd03586     1 IHIDMDAFYASVEQRDNPELKGKPVAVGGSSdrgVVSTASYEARKFGVRSAMPIFQAKKLCPNLIFVPPRFDKYREVSRQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 181 VKEILADYDPNFMAMSLDEAYLNITKHLeerqnwpedkrkyfikmgnsvendnpgkevnklsdhersispllfeespsdl 260
Cdd:cd03586    81 IMEILREYTPLVEPLSIDEAYLDVTDYV---------------------------------------------------- 108

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 261 lppgdpfqvnfeeqnspqilqnsiVFGTSAEEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPnrQ 340
Cdd:cd03586   109 ------------------------RLFGSATEIAKEIRARIREETGLTASAGIAPNKFLAKIASDLNKPNGLTVIPP--E 162

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 341 AVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQRALLSLLFSETSWHYFLHISLGLGSTYLTRDGERKSMSVER 420
Cdd:cd03586   163 DVEEFLAPLPVRKIPGVGKVTAEKLKELGIKTIGDLAKLDVELLKKLFGKSGRRLYELARGIDNRPVEPDRERKSIGVER 242

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 421 TFSE-INKAEEQYSLCEELCSELARDLQKEGLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKELLKTEIDad 499
Cdd:cd03586   243 TFSEdLTDPEELLEELLELAEELAERLRKRGLKGRTVTVKLKYADFSTRTRSRTLPEPTDDAEDIYELALELLEELLD-- 320

                         410
                  ....*....|....*..
gi 1622945228 500 fphPLRLRLMGVRISSF 516
Cdd:cd03586   321 ---GRPIRLLGVRLSGL 334
PRK02406 PRK02406
DNA polymerase IV; Validated
 108-522 1.52e-100

DNA polymerase IV; Validated


Pssm-ID: 235035 [Multi-domain]  Cd Length: 343  Bit Score: 316.29  E-value: 1.52e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 108 MDAFYAAVEMRDNPELKDKPIAVGS----MSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEVKE 183
Cdd:PRK02406    1 MDCFYAAVEMRDNPELRGKPVAVGGspgrRGVISTCNYEARKFGVRSAMPTAQALKLCPDLIFVPGRFDVYKEVSRQIRE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 184 ILADYDPNFMAMSLDEAYLNITkhleerqnwpedkrkyfikmgnsvenDNPgkevnklsdhersispllfeespsdllpp 263
Cdd:PRK02406   81 IFRRYTDLIEPLSLDEAYLDVT--------------------------DNK----------------------------- 105

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 264 gdpfqvnfeeQNSPqilqnsivfgtSAEEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPNRqaVM 343
Cdd:PRK02406  106 ----------LCIG-----------SATLIAQEIRQDIFEELGLTASAGVAPNKFLAKIASDWNKPNGLFVITPEE--VD 162

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 344 DFIKDLPIRKVSGIGKVTEKMLKALGIITCTELyQQRALLSLL-----FSetswHYFLHISLGLGSTYLTRDGERKSMSV 418
Cdd:PRK02406  163 AFLATLPVEKIPGVGKVTAEKLHALGIYTCADL-QKYDLAELIrhfgkFG----RRLYERARGIDERPVKPDRERKSVGV 237

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 419 ERTFSE-INKAEEQYSLCEELCSELARDLQKEG--LKGRTVTIKLKNVNFEVKTRaSTVSSVVSTAEEIFAIAKELLKTE 495
Cdd:PRK02406  238 ERTFAEdLYDLEACLAELPRLAEKLERRLERAKpdKRIKTVGVKLKFADFQQTTK-EHTADPLDKADLIELLAQALLRRL 316

                         410       420
                  ....*....|....*....|....*..
gi 1622945228 496 idadfpHPLRLRLMGVRISSFPNEEDR 522
Cdd:PRK02406  317 ------GGRGVRLLGVGVTLLEPQLER 337
DinP COG0389
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ...
 102-514 3.34e-97

Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];


Pssm-ID: 440158 [Multi-domain]  Cd Length: 336  Bit Score: 307.46  E-value: 3.34e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 102 TIVHIDMDAFYAAVEMRDNPELKDKPIAVGSMSM---LSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVS 178
Cdd:COG0389     2 RILHVDMDAFYASVEQRDRPELRGKPVAVGGDNNrgvVAAASYEARAFGVRSGMPLFQARRLCPDLVVLPPDFELYRDVS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 179 KEVKEILADYDPNFMAMSLDEAYLNITKhleerqnwpedkrkyfikmgnsvendnpgkevnklsdhersiSPLLFEesps 258
Cdd:COG0389    82 RRVMAILERYTPLVEPLSIDEAFLDVTG------------------------------------------SARLFG---- 115

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 259 dllppgdpfqvnfeeqnspqilqnsivfgtSAEEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPN 338
Cdd:COG0389   116 ------------------------------SAEAIARRIRRRIRRETGLTVSVGIAPNKFLAKIASDLAKPDGLTVIPPG 165

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 339 RQAvmDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQ-RALLSLLFSEtSWHYFLHISLGLGSTYLTRDGERKSMS 417
Cdd:COG0389   166 EVA--AFLAPLPVEKLWGVGPKTAEKLARLGIRTIGDLAALpRAELRRRFGK-VGERLYRLARGIDPRPVEPRRPRKSIG 242

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 418 VERTFSE-INKAEEQYSLCEELCSELARDLQKEGLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKELLktei 496
Cdd:COG0389   243 VERTFGEdLTDLEELEAALRRLAERLAERLRRQGLGARTVTVKLRTSDFRTTTRSRTLPEPTDDTAELLRAARELL---- 318

                         410
                  ....*....|....*...
gi 1622945228 497 DADFPHPLRLRLMGVRIS 514
Cdd:COG0389   319 ERIYRPGRPVRLLGVRLS 336
PTZ00205 PTZ00205
DNA polymerase kappa; Provisional
 17-558 8.76e-85

DNA polymerase kappa; Provisional


Pssm-ID: 140232 [Multi-domain]  Cd Length: 571  Bit Score: 282.29  E-value: 8.76e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228  17 LRMGLNDNKAGMEGLDKEKINKIIMEATKGSRFYGNELKKEKQVNQRIENMMQQKAQIT--------SQQLRKAQLQVDR 88
Cdd:PTZ00205   42 FQLTLDCNKAGMGNVDKERVEAIIRNVSEGSSFLMNEQRLAEGREKQLQELKRKSSLFTqllggernAAQRKQWELKVSK 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228  89 FAMELEQSRNLSnTIVHIDMDAFYAAVEMRDNPELKDKPIAVGSMSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVP 168
Cdd:PTZ00205  122 IEQELEATRRLG-TYIHLDMDMFYAAVEIKKHPEYAAIPLAIGTMTMLQTANYVARGRGIRQGMPGFLALKICPNLLILP 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 169 PNFDKYRAVSKEVKEILADYDPNFMAMSLDEAYLNITKHLEErqnwpedkrkyfikmgnsvendnpgkevnklsdhersi 248
Cdd:PTZ00205  201 PDFDAYNEESNTVRRIVAEYDPNYISFGLDELTLEVSAYIER-------------------------------------- 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 249 spllFEespsdllppgdpfqvnfeeqnspqilqnsivfGT-SAEEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKN 327
Cdd:PTZ00205  243 ----FE--------------------------------GTkTAEDVASELRVRVFGETKLTASAGIGPTAALAKIASNIN 286

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 328 KPNGQYQI-LPNRQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQRALLSLLFSETSWHYFLHISLGL---- 402
Cdd:PTZ00205  287 KPNGQHDLnLHTRGDVMTYVRDLGLRSVPGVGKVTEALLKGLGITTLSDIYNRRVELCYILHNNLFRFLLGASIGImqwp 366

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 403 ------------GSTyltrDGERKSMSVERTFSEINKAEEQYSLCEELCSELARDLQKEGLKGRTVTIKLKNVNFEVKTR 470
Cdd:PTZ00205  367 daataantenceGAT----GGQRKAISSERSFTTPRTKEGLQEMVDTVFNGAYEEMRKSELMCRQISLTIRWASYRYQQY 442

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 471 ASTVSSVVSTAEEIFAIAKELLkteidadFPHPLR---LRLMGVRISSFPNEEDRkHQQRsiigflQAGNQaLSATgcil 547
Cdd:PTZ00205  443 TKSLIQYSDDSATLRRAVDGLL-------LPHAAKyseMCLLGVRFLDLISAKDF-HMKR------KGGNQ-LSIS---- 503

                         570
                  ....*....|.
gi 1622945228 548 ektdkdQFVKP 558
Cdd:PTZ00205  504 ------QFIRP 508
PRK02794 PRK02794
DNA polymerase IV; Provisional
 102-516 9.02e-67

DNA polymerase IV; Provisional


Pssm-ID: 179473 [Multi-domain]  Cd Length: 419  Bit Score: 228.66  E-value: 9.02e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 102 TIVHIDMDAFYAAVEMRDNPELKDKPIAVG--SMSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSK 179
Cdd:PRK02794   37 SIAHIDCDAFYASVEKRDNPELRDKPVIIGggKRGVVSTACYIARIHGVRSAMPMFKALKLCPDAVVIKPDMEKYVRVGR 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 180 EVKEILADYDPNFMAMSLDEAYLNitkhleerqnwpedkrkyfikmgnsvendnpgkevnkLSDHERsisplLFEESPSD 259
Cdd:PRK02794  117 EVRAMMQALTPLVEPLSIDEAFLD-------------------------------------LSGTER-----LHGAPPAV 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 260 LLppgdpfqvnfeeqnspqilqnsivfgtsaeevvkeIRF--RIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGqYQILP 337
Cdd:PRK02794  155 VL-----------------------------------ARFarRVEREIGITVSVGLSYNKFLAKIASDLDKPRG-FSVIG 198

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 338 NRQAVmDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQ--QRALLSLLFSETSWHYflHISLGLGSTYLTRDGERKS 415
Cdd:PRK02794  199 RAEAL-AFLAPKPVGIIWGVGPATAARLARDGIRTIGDLQRadEADLMRRFGSMGLRLW--RLARGIDDRKVSPDREAKS 275

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 416 MSVERTFSE-INKAEEQYSLCEELCSELARDLQKEGLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKELLKT 494
Cdd:PRK02794  276 VSAETTFETdLSDFEDLEPILWRLSEKVSRRLKAAGLAGRTVTLKLKTADFRLRTRRRTLEDPTQLADRIFRTARELLEK 355

                         410       420
                  ....*....|....*....|..
gi 1622945228 495 EIDadfphPLRLRLMGVRISSF 516
Cdd:PRK02794  356 ETD-----GTAFRLIGIGVSDL 372
PRK14133 PRK14133
DNA polymerase IV; Provisional
 101-529 9.44e-66

DNA polymerase IV; Provisional


Pssm-ID: 184529 [Multi-domain]  Cd Length: 347  Bit Score: 223.83  E-value: 9.44e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 101 NTIVHIDMDAFYAAVEMRDNPELKDKPIAVGSMS---MLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAV 177
Cdd:PRK14133    3 RVIIHVDMDAFFASVEQMDNPKLKGKPVIVGGISergVVSTCSYEARKYGVHSAMPVFMAKKRCPHGIFLPVRHERYKEV 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 178 SKEVKEILADYDPNFMAMSLDEAYLNITkHLEErqnwpedkrkyfikmgnsvendNPgkevnklsdhersispllfeesp 257
Cdd:PRK14133   83 SKNIFKILYEVTPIVEPVSIDEAYLDIT-NIKE----------------------EP----------------------- 116

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 258 sdllppgdpfqvnfeeqnspqilqnsivfgtsaEEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQIlp 337
Cdd:PRK14133  117 ---------------------------------IKIAKYIKKKVKKETGLTLSVGISYNKFLAKLASDWNKPDGIKII-- 161

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 338 NRQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQ-QRALLSLLFSETSWHYFLHISlGLGSTYLTRDGERKSM 416
Cdd:PRK14133  162 TEDMIPDILKPLPISKVHGIGKKSVEKLNNIGIYTIEDLLKlSREFLIEYFGKFGVEIYERIR-GIDYREVEVSRERKSI 240

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 417 SVERTFS-EINKAEEQYSLCEELCSELARDLQKEGLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKELLKtE 495
Cdd:PRK14133  241 GKETTLKkDTKDKEELKKYLKDFSNIISEELKKRNLYGKTVTVKIKTSDFQTHTKSKTLNDYIRDKEEIYNVACEILE-H 319

                         410       420       430
                  ....*....|....*....|....*....|....
gi 1622945228 496 IDADFPhplrLRLMGVRISSFpneEDRKHQQRSI 529
Cdd:PRK14133  320 INIKEP----IRLIGLSVSNL---SENKIEQLSF 346
PRK03348 PRK03348
DNA polymerase IV; Provisional
 102-516 1.57e-55

DNA polymerase IV; Provisional


Pssm-ID: 235118 [Multi-domain]  Cd Length: 454  Bit Score: 198.62  E-value: 1.57e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 102 TIVHIDMDAFYAAVEMRDNPELKDKPIAVGSMS---MLSTSNYHARRFGVRAAMPGFIAKRLCPQL-IIVPPNFDKYRAV 177
Cdd:PRK03348    6 WVLHLDMDAFFASVEQLTRPTLRGRPVLVGGLGgrgVVAGASYEARVFGARSAMPMHQARRLVGNGaVVLPPRFVVYRAA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 178 SKEVKEILADYDPNFMAMSLDEAYlnitkhleerqnwpedkrkyfikmgnsVEndnpgkevnklsdhersispllfeesP 257
Cdd:PRK03348   86 SRRVFDTLRELSPVVEQLSFDEAF---------------------------VE--------------------------P 112

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 258 SDLLppgdpfqvnfeeqnspqilqnsivfGTSAEEVVK---EIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQ 334
Cdd:PRK03348  113 AELA-------------------------GASAEEVEAfaeRLRARVREETGLPASVGAGSGKQIAKIASGLAKPDGIRV 167

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 335 ILPNRQavMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQ--QRALLSLLfSETSWHYFLHISLGLGSTYLTRDGE 412
Cdd:PRK03348  168 VPPGEE--RELLAPLPVRRLWGIGPVTEEKLHRLGIETIGDLAAlsEAEVANLL-GATVGPALHRLARGIDDRPVAERAE 244

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 413 RKSMSVERTF-SEINKAEEQYSLCEELCSELARDLQKEGLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKEL 491
Cdd:PRK03348  245 AKQISAESTFaVDLTTRAQLREAIERIAEHAHRRLLKDGRGARTVTVKLRKSDFSTLTRSATLPYATDDAAVLAATARRL 324

                         410       420
                  ....*....|....*....|....*
gi 1622945228 492 LkteIDADFPHPlrLRLMGVRISSF 516
Cdd:PRK03348  325 L---LDPDEIGP--IRLVGVGFSGL 344
PolY cd00424
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases ...
 104-514 3.78e-50

Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Most TLS polymerases are members of the Y-family, including Pol eta, Pol kappa/IV, Pol iota, Rev1, and Pol V, which is found exclusively in bacteria. In eukaryotes, the B-family polymerase Pol zeta also functions as a TLS polymerase. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.


Pssm-ID: 176453 [Multi-domain]  Cd Length: 343  Bit Score: 180.25  E-value: 3.78e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 104 VHIDMDAFYAAVEMRDNPELKDKPIAVGSMSMLSTS----NYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSK 179
Cdd:cd00424     1 LHIDFDNFFASVEQLARPELKGRPVVVVPFNSDSTCviacSYEARKYGVKRGMPVREARKMCPNLILVPARLDLYRRLSE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 180 EVKEILADYDPNFMAMSLDEAYLNITKhleerqnwpedkrkyfikmgnsvendnpgkevnklSDHersispllfeespsd 259
Cdd:cd00424    81 RLLSELEEVAPLVEVASIDELFLDLTG-----------------------------------SAR--------------- 110

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 260 LLPPGdpfqvnfeeqnspqilqnsivfgtsaEEVVKEIRFRIEQKT-TLTASAGIAPNTMLAKVCSDKNKPNGQYQILPn 338
Cdd:cd00424   111 LLGLG--------------------------SEVALRIKRHIAEQLgGITASIGIASNKLLAKLAAKYAKPDGLTILDP- 163

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 339 rQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELY--QQRALLSLLFSETS--WHYFLHislGLGSTYLTRDGERK 414
Cdd:cd00424   164 -EDLPGFLSKLPLTDLPGIGAVTAKRLEAVGINPIGDLLaaSPDALLALWGGVSGerLWYALR---GIDDEPLSPPRPRK 239

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 415 SMSVERTF-SEINKAEEQYSLCEELCSELARDLQKEGLKGRTVTIKLKNVN------FEVKTRASTVSSVVSTaEEIFAI 487
Cdd:cd00424   240 SFSHERVLpRDSRNAEDARPLLRLLLEKLARRLRRDGRGATRLRLWLRTVDgrwsghADIPSRSAPRPISTED-GELLHA 318

                         410       420
                  ....*....|....*....|....*..
gi 1622945228 488 AKELLKTEIDAdfPHPLRLRLMGVRIS 514
Cdd:cd00424   319 LDKLWRALLDD--KGPRRLRRLGVRLS 343
PRK01810 PRK01810
DNA polymerase IV; Validated
 100-511 3.72e-49

DNA polymerase IV; Validated


Pssm-ID: 179337 [Multi-domain]  Cd Length: 407  Bit Score: 179.46  E-value: 3.72e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 100 SNTIVHIDMDAFYAAVEMRDNPELKDKPIAV-GSMS----MLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKY 174
Cdd:PRK01810    4 GRVIFHVDMNSFFASVEIAYDPSLQGKPLAVaGNEKerkgIIVTCSYEARAYGIRTTMPLWEAKRLCPQLIVRRPNFDRY 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 175 RAVSKEVKEILADYDPNFMAMSLDEAYLNITkhleerqnwpedkrkyfikmgnsvendnpgkevnklsDHERSISPLlfe 254
Cdd:PRK01810   84 REASRQMFQILSEFTPLVQPVSIDEGYLDIT-------------------------------------DCYALGSPL--- 123

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 255 espsdllppgdpfqvnfeeqnspqilqnsivfgtsaeEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGqYQ 334
Cdd:PRK01810  124 -------------------------------------EIAKMIQQRLLTELQLPCSIGIAPNKFLAKMASDMKKPLG-IT 165

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 335 ILPNRQaVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQ-QRALLSLLFsetswhyflhislGLGSTYL------ 407
Cdd:PRK01810  166 VLRKRD-VPEMLWPLPVGEMHGIGEKTAEKLKDIGIQTIGDLAKaDEHILRAKL-------------GINGVRLqrrang 231

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 408 --------TRDGERKSMSVERTFSEiNKAEEQ--YSLCEELCSELARDLQKEGLKGRTVTIKLKNVNFEVKTRASTVSSV 477
Cdd:PRK01810  232 iddrpvdpEAIYQFKSVGNSTTLSH-DMDEEKelLDVLRRLSKSVSKRLQKKTVVSYNVQIMIRYHDRRTITRSKTLKNP 310

                         410       420       430
                  ....*....|....*....|....*....|....
gi 1622945228 478 VSTAEEIFAIAKELLKTEIDADfphplRLRLMGV 511
Cdd:PRK01810  311 IWEKRDIFQAASRLFKQHWNGD-----PVRLLGV 339
PolY_Rev1 cd01701
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. ...
 81-514 7.31e-48

DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Rev1 has both structural and enzymatic roles. Structurally, it is believed to interact with other nonclassical polymerases and replication machinery to act as a scaffold. Enzymatically, it catalyzes the specific insertion of dCMP opposite abasic sites. Rev1 interacts with the Rev7 subunit of the B-family TLS polymerase Pol zeta (Rev3/Rev7). Rev1 is known to actively promote the introduction of mutations, potentially making it a significant target for cancer treatment.


Pssm-ID: 176455 [Multi-domain]  Cd Length: 404  Bit Score: 175.58  E-value: 7.31e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228  81 KAQLQvDRFAMELEQSRN----------LSNTIVHIDMDAFYAAVEMRDNPELKDKPIAV----GSMSMLSTSNYHARRF 146
Cdd:cd01701    18 KARLK-DFFRELSNGSKEadpsnsihpdLQRIIMHVDFDCFFVSVSIRNRPDLKGKPVAVchgkGPNSEIASCNYEARSY 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 147 GVRAAMpgFI--AKRLCPQLIIVPPNFDKYRAVSKEVKEILADYDPNFMAMSLDEAYLNITKHLEERQnwpedkrkyfik 224
Cdd:cd01701    97 GIKNGM--WVgqAKKLCPQLVTLPYDFEAYEEVSLTFYEILASYTDNIEAVSCDEALIDITSLLEETY------------ 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 225 mgnsvendnpgkevnklsdhersispllfeespsdllppgdpfqvnfeeqnspqilqnsivfgTSAEEVVKEIRFRIEQK 304
Cdd:cd01701   163 ---------------------------------------------------------------ELPEELAEAIRNEIRET 179

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 305 TTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPnrQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQ----R 380
Cdd:cd01701   180 TGCSASVGIGPNILLARLATRKAKPDGQYHLSA--EKVEEFLSQLKVGDLPGVGSSLAEKLVKLFGDTCGGLELRsktkE 257

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 381 ALLSLLFSETSWHyFLHISLGLGSTYLTRDGERKSMSVertfsEIN------KAEEQYSLCEELCSELARDLQKEGLKGR 454
Cdd:cd01701   258 KLQKVLGPKTGEK-LYDYCRGIDDRPVTGEKERKSVSA-----EINygirftNVDDVEQFLQRLSEELSKRLEESNVTGR 331

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622945228 455 TVTIKLKN------------------VNFevkTRASTVSSVVSTAEEIFAIAKELLKTeIDADfphPLRLRLMGVRIS 514
Cdd:cd01701   332 QITLKLMKrapgapieppkymghgicDSF---SKSSTLGVATDDSGVIGTEAKKLFRD-LSIP---PEELRGVGIQVT 402
PRK03858 PRK03858
DNA polymerase IV; Validated
 102-526 1.93e-47

DNA polymerase IV; Validated


Pssm-ID: 179663 [Multi-domain]  Cd Length: 396  Bit Score: 174.02  E-value: 1.93e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 102 TIVHIDMDAFYAAVEMRDNPELKDKPIAVGSMSMLSTSnYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEV 181
Cdd:PRK03858    5 SILHADLDSFYASVEQRDDPALRGRPVIVGGGVVLAAS-YEAKAYGVRTAMGGRQARRLCPQAVVVPPRMSAYSRASKAV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 182 KEILADYDPNFMAMSLDEAYLnitkhleerqnwpedkrkyfikmgnsvendnpgkEVNKLSDhersispllfeespsdll 261
Cdd:PRK03858   84 FEVFRDTTPLVEGLSIDEAFL----------------------------------DVGGLRR------------------ 111

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 262 ppgdpfqvnfeeqnspqilqnsiVFGTSAeEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPNRQa 341
Cdd:PRK03858  112 -----------------------ISGTPV-QIAARLRRRVREEVGLPITVGVARTKFLAKVASQVAKPDGLLVVPPDRE- 166

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 342 vMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQ--QRALLSLLFSETSWHyfLH-ISLGLGSTYLTRDGERKSMSV 418
Cdd:PRK03858  167 -LAFLHPLPVRRLWGVGPVTAAKLRAHGITTVGDVAElpESALVSLLGPAAGRH--LHaLAHNRDPRRVETGRRRRSVGA 243

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 419 ERTFSE-INKAEEQYSLCEELCSELARDLQKEGLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKELLkteiD 497
Cdd:PRK03858  244 QRALGRgPNSPAEVDAVVVALVDRVARRMRAAGRTGRTVVLRLRFDDFTRATRSHTLPRPTASTATLLAAARDLV----A 319

                         410       420       430
                  ....*....|....*....|....*....|.
gi 1622945228 498 ADFP-HPLR-LRLMGVRISsfpNEEDRKHQQ 526
Cdd:PRK03858  320 AAAPlIAERgLTLVGFAVS---NLDDDGAQQ 347
IMS pfam00817
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
 106-325 2.39e-46

impB/mucB/samB family; These proteins are involved in UV protection (Swiss).


Pssm-ID: 425885 [Multi-domain]  Cd Length: 148  Bit Score: 162.36  E-value: 2.39e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 106 IDMDAFYAAVEMRDNPELKDKPIAVGS---MSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEVK 182
Cdd:pfam00817   1 IDMDAFFASVELLRDPELKGKPVAVGGgngRGIVAAASYEARKYGVRSGMPVFEAKKLCPNLIVVPPDLELYRRASRKIF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 183 EILADY-DPNFMAMSLDEAYLNITKHLEerqnwpedkrkyfikmgnsvendnpgkevnklsdhersisplLFEespsdll 261
Cdd:pfam00817  81 EILRRFsTPKVEQASIDEAFLDLTGLEK------------------------------------------LFG------- 111

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622945228 262 ppgdpfqvnfeeqnspqilqnsivfgtSAEEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSD 325
Cdd:pfam00817 112 ---------------------------AEEALAKRLRREIAEETGLTCSIGIAPNKLLAKLASD 148
PolY_Pol_eta cd01702
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. ...
 104-518 3.21e-35

DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Unlike other Y-family members, Pol eta can efficiently and accurately replicate DNA past UV-induced lesions. Its activity is initiated by two simultaneous interactions: the PIP box in pol eta interacting with PCNA, and the UBZ (ubiquitin-binding zinc finger) in pol eta interacting with monoubiquitin attached to PCNA. Pol eta is more efficient in copying damaged DNA than undamaged DNA and seems to recognize when a lesion has been passed, facilitating a lesion-dependent dissociation from the DNA.


Pssm-ID: 176456 [Multi-domain]  Cd Length: 359  Bit Score: 137.83  E-value: 3.21e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 104 VHIDMDAFYAAVEMRDNPELKDKPIAVGSMSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLII--VPP------------ 169
Cdd:cd01702     1 AHIDMDAFFAQVEQVRLGLLRNDPVAVVQWNSIIAVSYAARAFGVTRFMTIDEAKKKCPDLILahVATykkgedeadyhe 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 170 ---------NFDKYRAVSKEVKEILADYDPNFMAMSLDEAYLnitkhleerqnwpedkrkyfikmgnsvendnpgkevnk 240
Cdd:cd01702    81 npsparhkvSLDPYRRASRKILNILKRFGDVVEKASIDEAYL-------------------------------------- 122

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 241 lsdhersispllfeespsDLlppgdpfqvnfeeqnspqilqnsivfgtsAEEVVKEIRFRIEQKTTLTASAGIAPNTMLA 320
Cdd:cd01702   123 ------------------DL-----------------------------GSRIVEEIRQQVYDELGYTCSAGIAHNKMLA 155

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 321 KVCSDKNKPNGQyQILPNRqAVMDFIKDLPIRKVSGI-GKVTEKMLKALGIITCTELYQQRALLSLL---FSET--SWHY 394
Cdd:cd01702   156 KLASGMNKPNAQ-TILRND-AVASFLSSLPITSIRGLgGKLGEEIIDLLGLPTEGDVAGFRSSESDLqehFGEKlgEWLY 233

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 395 flHISLGLGSTYLTRDGERKSMSVERTFS-EINKAEEQYS-----LCEELCSELARDLQKEGLKGRTVTIKLKNVNFEVK 468
Cdd:cd01702   234 --NLLRGIDHEPVKPRPLPKSMGSSKNFPgKTALSTEDVQhwllvLASELNSRLEDDRYENNRRPKTLVLSLRQRGDGVR 311

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|
gi 1622945228 469 TRASTVSSVVsTAEEIFAIAKELLKtEIDADFPHPLRLRLMGVRISSFPN 518
Cdd:cd01702   312 RSRSCALPRY-DAQKIVKDAFKLIK-AINEEGLGLAWNYPLTLLSLSFTK 359
PRK03352 PRK03352
DNA polymerase IV; Validated
 103-520 5.00e-35

DNA polymerase IV; Validated


Pssm-ID: 179564 [Multi-domain]  Cd Length: 346  Bit Score: 136.69  E-value: 5.00e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 103 IVHIDMDAFYAAVEMRDNPELKDKPIAVG-------SMSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYR 175
Cdd:PRK03352    7 VLHVDLDQFIAAVELLRRPELAGLPVIVGgngdptePRKVVTCASYEARAFGVRAGMPLRTAARRCPDAVFLPSDPAAYD 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 176 AVSKEVKEILADYDPNFMAMSLDEAYLNITkhleerqnwpedkrkyfikmgnsvendnpgkevnklsdhersispllfee 255
Cdd:PRK03352   87 AASEEVMATLRDLGVPVEVWGWDEAFLGVD-------------------------------------------------- 116

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 256 spsdllpPGDPfqvnfeeqnspqilqnsivfgtsaEEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQI 335
Cdd:PRK03352  117 -------TDDP------------------------EALAEEIRAAVLERTGLSCSVGIGDNKLRAKIATGFAKPAGVFRL 165

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 336 lpNRQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTEL-YQQRALLSLLFSETSWHYFLHISLGLGSTYLTRDG-ER 413
Cdd:PRK03352  166 --TDANWMAVMGDRPTDALWGVGPKTAKRLAALGITTVADLaAADPAELAATFGPTTGPWLLLLARGGGDTEVSAEPwVP 243

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 414 KSMSVERTFSE-INKAEEQYSLCEELCSELARDLQKEGLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKELL 492
Cdd:PRK03352  244 RSRSREVTFPQdLTDRAEVESAVRELARRVLDEVVAEGRPVTRVAVKVRTATFYTRTKIRKLPEPTTDPDVIEAAALDVL 323

                         410       420
                  ....*....|....*....|....*...
gi 1622945228 493 KtEIDADFPhplrLRLMGVRISSFPNEE 520
Cdd:PRK03352  324 D-RFELDRP----VRLLGVRLELAMPDE 346
PRK03103 PRK03103
DNA polymerase IV; Reviewed
 103-529 9.09e-35

DNA polymerase IV; Reviewed


Pssm-ID: 235104 [Multi-domain]  Cd Length: 409  Bit Score: 137.44  E-value: 9.09e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 103 IVHIDMDAFYAAVEMRDNPELKDKPIAVG------SMSMLSTSnYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRA 176
Cdd:PRK03103    5 ILLVDMQSFYASVEKAANPELKGRPVIVSgdperrSGVVLAAC-PLAKAYGVKTAERLWEAQQKCPDLVVVKPRMQRYID 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 177 VSKEVKEILADYDPNFMAMSLDEAYLNITKhleerqnwpedkrkyfikmgnsvendnpgkevnklsdhersiSPLLFees 256
Cdd:PRK03103   84 VSLQITRILEDFTDLVEPFSIDEQFLDVTG------------------------------------------SQKLF--- 118

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 257 psdllppGDPfqvnfeeqnspqilqnsivfgtsaEEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSD---KNKPNGQY 333
Cdd:PRK03103  119 -------GSP------------------------LEIAQKIQQRIMRETGVYARVGIGPNKLLAKMACDnfaKKNPDGLF 167

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 334 QIlpNRQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELyqqrALLSLLFSETSW----HYFLHISLGLGSTYLTR 409
Cdd:PRK03103  168 TL--DKEDVPADLWPLPVRKLFGVGSRMEKHLRRMGIRTIGQL----ANTPLERLKKRWgingEVLWRTANGIDYSPVTP 241

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 410 DG--ERKSMSVERTF-SEINKAEEQYSLCEELCSELARDLQKEGLKGRTVTIKLKNVNFEVKT---RASTVSSVVSTAEE 483
Cdd:PRK03103  242 HSldRQKAIGHQMTLpRDYRGFEEIKVVLLELCEEVCRRARAKGYMGRTVSVSLRGADFDWPTgfsRQMTLPEPTNLAME 321

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1622945228 484 IFAIAKELLKTEIDAdfphpLRLRLMGVRISSF-PNEE------DRKHQQRSI 529
Cdd:PRK03103  322 VYEAACKLFHRHWDG-----KPVRRVGVTLSNLvSDDVwqlslfGDRERKRSL 369
PolY_Pol_iota cd01703
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. ...
 104-511 2.23e-32

DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol iota is thought to be one of the least efficient polymerases, particularly when opposite pyrimidines; it can incorporate the correct nucleotide opposite a purine much more efficiently than opposite a pyrimidine, and prefers to insert guanosine instead of adenosine opposite thymidine. Pol iota is believed to use Hoogsteen rather than Watson-Crick base pairing, which may explain the varying efficiency for different template nucleotides.


Pssm-ID: 176457 [Multi-domain]  Cd Length: 379  Bit Score: 129.90  E-value: 2.23e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 104 VHIDMDAFYAAVEMRDNPELKDKPIAVGSMSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVP-PNFDKYRAVSKEVK 182
Cdd:cd01703     1 IHLDLDCFYAQVEEIRDPSLKSKPLGIQQKYIVVTCNYEARRLGVKKLMSIKDAKEICPDLVLVNgEDLTPFRDMSKKVY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 183 EILADYDPNFMA--MSLDEAYLNITkhleerqnwpeDKRkyfikmgnsvendnpgkevnklsdhersispLLFeespsdl 260
Cdd:cd01703    81 RLLRSYSWNDRVerLGFDENFMDVT-----------EMR-------------------------------LLV------- 111

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 261 lppgdpfqvnfeeqnspqilqnsivfgtsAEEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILP-NR 339
Cdd:cd01703   112 -----------------------------ASHIAYEMRERIENELGLTCCAGIASNKLLAKLVGSVNKPNQQTTLLPpSC 162

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 340 QAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELyQQRALLSLLFSETSWHYFLHISLGLGSTYLT----------R 409
Cdd:cd01703   163 ADLMDFMDLHDLRKIPGIGYKTAAKLEAHGISSVRDL-QEFSNRNRQTVGAAPSLLELLLMVKEFGEGIgqriwkllfgR 241

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 410 DGER--------KSMSVERTF-----SEINKAEEQY-----SLCEELCSELARDLQKEGLKGRTVTIKL-------KNVN 464
Cdd:cd01703   242 DTSPvkpasdfpQQISIEDSYkkcslEEIREARNKIeellaSLLERMKQDLQEVKAGDGRRPHTLRLTLrrytstkKHYN 321

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1622945228 465 FEVKTrASTVSSVVST--------AEEIFAIAKELLKTEIDADFPHPLRLRLMGV 511
Cdd:cd01703   322 RESKQ-APIPSHVFQKltggneiaARPIEKILMRLFRELVPPKNVKGFNLTLLNV 375
PRK01216 PRK01216
DNA polymerase IV; Validated
 103-370 3.50e-31

DNA polymerase IV; Validated


Pssm-ID: 179251 [Multi-domain]  Cd Length: 351  Bit Score: 125.67  E-value: 3.50e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 103 IVHIDMDAFYAAVEMRDNPELKDKPIAVGSMS-------MLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYR 175
Cdd:PRK01216    3 ILFVDFDYFFAQVEEVLNPSLKGKPVVVCVYSgrfedsgAVATANYEARKLGIKAGMPIVEAKKILPNAVYLPMRKEVYQ 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 176 AVSKEVKEILADYDPNFMAMSLDEAYLNITKHLEerqnwpedkrkyfikmgnsvendnpgkevnklsdhersispllfee 255
Cdd:PRK01216   83 QVSNRIMKLLREYSEKIEIASIDEAYLDISDKVK---------------------------------------------- 116

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 256 spsdllppgdpfqvNFEEqnspqilqnsivfgtsAEEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQI 335
Cdd:PRK01216  117 --------------NYQD----------------AYNLGLEIKNKILEKEKITVTVGISKNKVFAKIAADMAKPNGIKVI 166

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1622945228 336 LPnrQAVMDFIKDLPIRKVSGIGKVTEKMLKALGI 370
Cdd:PRK01216  167 DD--EEVKRFINELDIADIPGIGDITAEKLKKLGV 199
PolY_Pol_V_umuC cd01700
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion ...
 106-458 2.80e-27

umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion synthesis (TLS) polymerase that consists of the heterotrimer of one umuC and two umuD subunits. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol V, RecA, single stranded DNA-binding protein, beta sliding clamp, and gamma clamp loading complex are responsible for inducing the SOS response in bacteria to repair UV-induced DNA damage.


Pssm-ID: 176454 [Multi-domain]  Cd Length: 344  Bit Score: 113.80  E-value: 2.80e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 106 IDMDAFYAAVEMRDNPELKDKPIAVgsmsmLSTS-------NYHARRFGVRAAMPGFIAKRLCPQL--IIVPPNFDKYRA 176
Cdd:cd01700     3 VDCNSFYASCERVFRPLLLGRPLVV-----LSNNdgcviarSPEAKALGIKMGSPYFKVPDLLERHgvAVFSSNYALYGD 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 177 VSKEVKEILADYDPNFMAMSLDEAYLNITkhleerqnwpedkrkyfikmgnsvendnpgkevnklsdhersispllfees 256
Cdd:cd01700    78 MSRRIMSILERFSPDVEVYSIDESFLDLT--------------------------------------------------- 106

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 257 psDLLPPGDPfqvnfeeqnspqilqnsivfgtsaEEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSD----KNKPNGQ 332
Cdd:cd01700   107 --GSLRFGDL------------------------EELARKIRRRILQETGIPVTVGIGPTKTLAKLANDlakkKNPYGGV 160

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 333 YQIL--PNRQAVMdfiKDLPIRKVSGIGKVTEKMLKALGIIT-----CTELYQQRALLSLLFSETSWHyfLH-IS-LGLG 403
Cdd:cd01700   161 VDLTdeEVRDKLL---KILPVGDVWGIGRRTAKKLNAMGIHTagdlaQADPDLLRKKFGVVGERLVRE--LNgIDcLPLE 235

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622945228 404 STyltrDGERKSMSVERTFSE--INKAEEQYSLCeELCSELARDLQKEGLKGRTVTI 458
Cdd:cd01700   236 EY----PPPKKSIGSSRSFGRdvTDLDELKQALA-EYAERAAEKLRRQKSVARTISV 287
IMS_C pfam11799
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss).
 413-520 1.94e-23

impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss).


Pssm-ID: 463354 [Multi-domain]  Cd Length: 104  Bit Score: 95.70  E-value: 1.94e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 413 RKSMSVERTFSE-INKAEEQYSLCEELCSELARDLQKEGLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKEL 491
Cdd:pfam11799   1 RKSIGAERTFGRdLTDLEELREALLELAEELAERLRRQGLVARTVTVKIRYSDFRTITRSVTLPSPTDDTDEIYRAALRL 80

                          90       100
                  ....*....|....*....|....*....
gi 1622945228 492 LKteidaDFPHPLRLRLMGVRISSFPNEE 520
Cdd:pfam11799  81 LR-----RLYRGRPVRLLGVSLSNLVPEG 104
IMS_HHH pfam11798
IMS family HHH motif; These proteins are involved in UV protection, eg.
 339-370 9.00e-07

IMS family HHH motif; These proteins are involved in UV protection, eg.


Pssm-ID: 432081 [Multi-domain]  Cd Length: 32  Bit Score: 45.85  E-value: 9.00e-07
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1622945228 339 RQAVMDFIKDLPIRKVSGIGKVTEKMLKALGI 370
Cdd:pfam11798   1 PDDVPEFLWPLPISKIPGIGKKLAEKLKALGI 32
umuC PRK03609
translesion error-prone DNA polymerase V subunit UmuC;
105-379 3.49e-05

translesion error-prone DNA polymerase V subunit UmuC;


Pssm-ID: 179607 [Multi-domain]  Cd Length: 422  Bit Score: 47.07  E-value: 3.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 105 HIDMDAFYAAVEMRDNPELKDKPIAVGSMS--MLSTSNYHARRFGVRAAMPGFIAK--RLCPQLIIVPPNFDKYRAVSKE 180
Cdd:PRK03609    4 LCDVNSFYASCETVFRPDLRGKPVVVLSNNdgCVIARSAEAKALGIKMGDPWFKQKdlFRRCGVVCFSSNYELYADMSNR 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 181 VKEILADYDPNFMAMSLDEAYLNITkhleerqnwpedkrkyfikmgnSVENdnpgkeVNKLSDhersispllfeespsdl 260
Cdd:PRK03609   84 VMSTLEELSPRVEIYSIDEAFCDLT----------------------GVRN------CRDLTD----------------- 118

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 261 lppgdpfqvnfeeqnspqilqnsivFGtsaeevvKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKP----NGQYQIL 336
Cdd:PRK03609  119 -------------------------FG-------REIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKwqrqTGGVVDL 166

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1622945228 337 PNRQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQ 379
Cdd:PRK03609  167 SNLERQRKLLSLQPVEEVWGVGRRISKKLNAMGIKTALDLADT 209
PolY_like cd03468
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that ...
 297-493 1.69e-04

DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.


Pssm-ID: 176458 [Multi-domain]  Cd Length: 335  Bit Score: 44.68  E-value: 1.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 297 IRFRIEQKTT-LTASAGIAPNTMLAKVCSDKNKPNGQYQIlPNRQAVMDFIKDLPIRkVSGIGKVTEKMLKALGIIT--- 372
Cdd:cd03468   119 ASLRAALATLgLSARAGIADTPGAAWLLARAGGGRGVLRR-EALAAALVLLAPLPVA-ALRLPPETVELLARLGLRTlgd 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945228 373 CTELYqqRALLSLLFSE--TSWHYFLhislgLGSTYLTRDG----ERKSMSVERTFsEINKAEEQYSLCEELCSELARDL 446
Cdd:cd03468   197 LAALP--RAELARRFGLalLLRLDQA-----YGRDPEPLLFspppPAFDFRLELQL-EEPIARGLLFPLRRLLEQLCAFL 268

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1622945228 447 QKEGLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKELLK 493
Cdd:cd03468   269 ALRGLGARRLSLTLFREDGRVTRVLVGLARPSRDDLPLLRLLRERLE 315
ZnF_Rad18 smart00734
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ...
 777-803 2.64e-04

Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.


Pssm-ID: 128973 [Multi-domain]  Cd Length: 24  Bit Score: 38.74  E-value: 2.64e-04
                           10        20
                   ....*....|....*....|....*..
gi 1622945228  777 ALVCPVCNVEQKtsdLTLFNVHVDVCL 803
Cdd:smart00734   1 LVQCPVCFREVP---ENLINSHLDSCL 24
ZnF_Rad18 smart00734
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ...
 621-647 4.71e-04

Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.


Pssm-ID: 128973 [Multi-domain]  Cd Length: 24  Bit Score: 37.97  E-value: 4.71e-04
                           10        20
                   ....*....|....*....|....*..
gi 1622945228  621 IFTCPVCFRAQgciSLEAFNKHVDACL 647
Cdd:smart00734   1 LVQCPVCFREV---PENLINSHLDSCL 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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