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Conserved domains on  [gi|966947066|ref|XP_014995583|]
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importin-11 isoform X3 [Macaca mulatta]

Protein Classification

importin-beta family protein( domain architecture ID 1004407)

importin-beta family protein may be involved in nuclear transport and play a role in the import and export of proteins and RNAs from the nucleus.

Gene Ontology:  GO:0061608|GO:0031267|GO:0006606

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CSE1 super family cl35039
CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning]; ...
10-980 1.72e-49

CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5657:

Pssm-ID: 227944 [Multi-domain]  Cd Length: 947  Bit Score: 190.02  E-value: 1.72e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966947066  10 VLQVLTQATSQDTAVLKPAEEQLKQWETQPGFYSVLLNIFTNHTLDINVRWLAVLYFKHGIDRYWRRVAPHALSEEEKTT 89
Cdd:COG5657    6 VVKQLDLAQSPDPPSVKCAEERLRQWEKQHGFALKLLSINLSAFNSMSLRWAALIQFKNYIDKHWREENGNSILPDENVL 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966947066  90 LRAGLITNFNEPINQIATQIAVLIAKVARLDCPRQWPELIPTLIESVKVQDDLRQHRALLTFYHVTKTLAskRLAADRKL 169
Cdd:COG5657   86 IRDELFSLIISSSNQLQIQNALAVSRIARLDFPDEWPTLVPDLLSLLSEKDMVTNENSLRVLHHIFKRLR--RLFRSDAL 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966947066 170 FYDLASGIYNFACSLWNHHTDTFLQqvSSGNEAVILSSLERTLlslKVLRKLTVNGFVEPHKNME-----VMGFLHGIFE 244
Cdd:COG5657  164 FLEIAPVLLSILCPFLFSSAYFWSM--SENLDESLLSLFQVCL---KLIRRYYDLGFQDIPEFFEdnldkFMEHFCKLLS 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966947066 245 RLKQFLE--CSRSIGTDNVCRDRLEkTIILFTKVLLDFLDQHPFSFTPLIQRSLEfsvSYVFTEVGEGVTFERFIVqCMN 322
Cdd:COG5657  239 YSNPVLQkdCLEDCVYFKLKGSICE-IFNLYTTKYPEVITYLIYDFVEIVWNLLT---TITRPYIRDYLVSKSLTV-LIN 313
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966947066 323 LIKMIVKNYAYKPSKNFEDSSPETLEAhkikmafftyptlteicrrLVSHYFLLTEEELTMWEEDPEGFTVEETGGDSwK 402
Cdd:COG5657  314 VIKYPIRKTAEVLSNVSENLINNLVDL-------------------LILPNLILREEDLEEWEDDPLEYIREQSKTDY-E 373
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966947066 403 YSLRPCTEVLFIDIFHEYNQTLTPVLLEMMQtlQGPTNVEDMNALLIKDAVYNAVGLAAYELFDSVDFDQWFKNQLLPEL 482
Cdd:COG5657  374 VNVRPCIENELKDLFDVFGRIAVGHELTVIE--SEATTPNILDEARQLFAAYASFGLGVEAVNRMVDFVKFLGSIIYPDL 451
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966947066 483 ----QVIHNRYkpLRRRVIWLIGQWISVK--FKSDLRPMLYEAICNLLQDQDLVIQIYFDRTYVFSIFlncaspvDDFEF 556
Cdd:COG5657  452 lspnEIIHLRI--LRSRIAYILTFRNQLDssELSESKFLASQFFVNYTTACIDAVVLLTTREAYSTIF-------DDWNF 522
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966947066 557 RTDQFLPYLETMFTLLFQLLQQVTECDTKMHVLHVLSCVIERVNMQIRPYVGCLVQYLPLLWKQSEEhNMLRCAILTTLI 636
Cdd:COG5657  523 SVCSKIGLLENLILLVLSLMASPSSLEEREFLLQLISRIIIIDPELIAPLGSEILQLLDNLVEINAK-NPSNPQFAHYTF 601
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966947066 637 HLVQGLGADSKNLYPFLLPVIQLStdVSQPPHVYLLEDGLELWLVtlenspcitpellrIFQNMSPLLELSS-ENLRTCF 715
Cdd:COG5657  602 EDIGALVFLKSGMCEITIPTLVLA--LVPEFPVLLSEDATELWSY--------------VLQLLSILPEHFSgDVLPSVV 665
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966947066 716 KIIngYIFLSSTEFLQTyAVGLCQSFCELLKEITTEGQ-------VQVLKVVENALKVNP------ILGPQMFQPILPYV 782
Cdd:COG5657  666 KIL--RQPSLATELLPT-KLEILKSYRLLDNPILTTGYifkssgfQPVLGILQYLLGSEPhdalcfLNLTVVETLYLENI 742
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966947066 783 FKGIIEGERYPVVMSTYLGVMGRVLLQNTSFFSSLLN---------EMAHKFNQEMDQLLGNMIEMWVDRMDNITQPERR 853
Cdd:COG5657  743 YEPYVNLIFVLLLSRLKNSKTERFVIKIIHVFSLVSFkdsltvgcdNLISKINQTKNILIVQLYGNWILGFDEIHDSKDR 822
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966947066 854 KLSALaLLSLLPSDNSVIQDKFCGIINISVEglhdVMTEDPETGTyKDCMLmSHLEEPKVTE--DEEPPTEQDKRKKMLA 931
Cdd:COG5657  823 KIHLI-GLSNLLRTLHPEVLSYVSVTNLIIS----LLSEIFETAS-GDAII-YELNDDYADDwfDGEISAEEFSRLAQLE 895
                        970       980       990      1000      1010
                 ....*....|....*....|....*....|....*....|....*....|..
gi 966947066 932 LK-DPVHMVSL-QQFIYEKLKAQQEMLG-EQGFQSLMETVDTEIVTQLQEFL 980
Cdd:COG5657  896 FKvDPVHDIDNtKYFISFFMEAMNSNLGnENEIVFRLPTENQSLLEQLQEKL 947
 
Name Accession Description Interval E-value
CSE1 COG5657
CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning]; ...
10-980 1.72e-49

CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning];


Pssm-ID: 227944 [Multi-domain]  Cd Length: 947  Bit Score: 190.02  E-value: 1.72e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966947066  10 VLQVLTQATSQDTAVLKPAEEQLKQWETQPGFYSVLLNIFTNHTLDINVRWLAVLYFKHGIDRYWRRVAPHALSEEEKTT 89
Cdd:COG5657    6 VVKQLDLAQSPDPPSVKCAEERLRQWEKQHGFALKLLSINLSAFNSMSLRWAALIQFKNYIDKHWREENGNSILPDENVL 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966947066  90 LRAGLITNFNEPINQIATQIAVLIAKVARLDCPRQWPELIPTLIESVKVQDDLRQHRALLTFYHVTKTLAskRLAADRKL 169
Cdd:COG5657   86 IRDELFSLIISSSNQLQIQNALAVSRIARLDFPDEWPTLVPDLLSLLSEKDMVTNENSLRVLHHIFKRLR--RLFRSDAL 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966947066 170 FYDLASGIYNFACSLWNHHTDTFLQqvSSGNEAVILSSLERTLlslKVLRKLTVNGFVEPHKNME-----VMGFLHGIFE 244
Cdd:COG5657  164 FLEIAPVLLSILCPFLFSSAYFWSM--SENLDESLLSLFQVCL---KLIRRYYDLGFQDIPEFFEdnldkFMEHFCKLLS 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966947066 245 RLKQFLE--CSRSIGTDNVCRDRLEkTIILFTKVLLDFLDQHPFSFTPLIQRSLEfsvSYVFTEVGEGVTFERFIVqCMN 322
Cdd:COG5657  239 YSNPVLQkdCLEDCVYFKLKGSICE-IFNLYTTKYPEVITYLIYDFVEIVWNLLT---TITRPYIRDYLVSKSLTV-LIN 313
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966947066 323 LIKMIVKNYAYKPSKNFEDSSPETLEAhkikmafftyptlteicrrLVSHYFLLTEEELTMWEEDPEGFTVEETGGDSwK 402
Cdd:COG5657  314 VIKYPIRKTAEVLSNVSENLINNLVDL-------------------LILPNLILREEDLEEWEDDPLEYIREQSKTDY-E 373
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966947066 403 YSLRPCTEVLFIDIFHEYNQTLTPVLLEMMQtlQGPTNVEDMNALLIKDAVYNAVGLAAYELFDSVDFDQWFKNQLLPEL 482
Cdd:COG5657  374 VNVRPCIENELKDLFDVFGRIAVGHELTVIE--SEATTPNILDEARQLFAAYASFGLGVEAVNRMVDFVKFLGSIIYPDL 451
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966947066 483 ----QVIHNRYkpLRRRVIWLIGQWISVK--FKSDLRPMLYEAICNLLQDQDLVIQIYFDRTYVFSIFlncaspvDDFEF 556
Cdd:COG5657  452 lspnEIIHLRI--LRSRIAYILTFRNQLDssELSESKFLASQFFVNYTTACIDAVVLLTTREAYSTIF-------DDWNF 522
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966947066 557 RTDQFLPYLETMFTLLFQLLQQVTECDTKMHVLHVLSCVIERVNMQIRPYVGCLVQYLPLLWKQSEEhNMLRCAILTTLI 636
Cdd:COG5657  523 SVCSKIGLLENLILLVLSLMASPSSLEEREFLLQLISRIIIIDPELIAPLGSEILQLLDNLVEINAK-NPSNPQFAHYTF 601
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966947066 637 HLVQGLGADSKNLYPFLLPVIQLStdVSQPPHVYLLEDGLELWLVtlenspcitpellrIFQNMSPLLELSS-ENLRTCF 715
Cdd:COG5657  602 EDIGALVFLKSGMCEITIPTLVLA--LVPEFPVLLSEDATELWSY--------------VLQLLSILPEHFSgDVLPSVV 665
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966947066 716 KIIngYIFLSSTEFLQTyAVGLCQSFCELLKEITTEGQ-------VQVLKVVENALKVNP------ILGPQMFQPILPYV 782
Cdd:COG5657  666 KIL--RQPSLATELLPT-KLEILKSYRLLDNPILTTGYifkssgfQPVLGILQYLLGSEPhdalcfLNLTVVETLYLENI 742
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966947066 783 FKGIIEGERYPVVMSTYLGVMGRVLLQNTSFFSSLLN---------EMAHKFNQEMDQLLGNMIEMWVDRMDNITQPERR 853
Cdd:COG5657  743 YEPYVNLIFVLLLSRLKNSKTERFVIKIIHVFSLVSFkdsltvgcdNLISKINQTKNILIVQLYGNWILGFDEIHDSKDR 822
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966947066 854 KLSALaLLSLLPSDNSVIQDKFCGIINISVEglhdVMTEDPETGTyKDCMLmSHLEEPKVTE--DEEPPTEQDKRKKMLA 931
Cdd:COG5657  823 KIHLI-GLSNLLRTLHPEVLSYVSVTNLIIS----LLSEIFETAS-GDAII-YELNDDYADDwfDGEISAEEFSRLAQLE 895
                        970       980       990      1000      1010
                 ....*....|....*....|....*....|....*....|....*....|..
gi 966947066 932 LK-DPVHMVSL-QQFIYEKLKAQQEMLG-EQGFQSLMETVDTEIVTQLQEFL 980
Cdd:COG5657  896 FKvDPVHDIDNtKYFISFFMEAMNSNLGnENEIVFRLPTENQSLLEQLQEKL 947
IBN_N pfam03810
Importin-beta N-terminal domain;
28-100 1.55e-17

Importin-beta N-terminal domain;


Pssm-ID: 397745 [Multi-domain]  Cd Length: 72  Bit Score: 77.66  E-value: 1.55e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966947066   28 AEEQLKQWETQPGFYSVLLNIFTNHTLDINVRWLAVLYFKHGIDRYWRRVApHALSEEEKTTLRAGLITNFNE 100
Cdd:pfam03810   1 AEKQLEQFEKSPGFWSKLLQILSNSENPLEVRQLAALYLKNLITRHWEEEK-NSLPPEEKEQIKNNLLNLLGS 72
IBN_N smart00913
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ...
28-95 1.33e-12

Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport.


Pssm-ID: 197981 [Multi-domain]  Cd Length: 67  Bit Score: 63.42  E-value: 1.33e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966947066    28 AEEQLKQWETQPGFYSVLLNIFTNHTlDINVRWLAVLYFKHGIDRYWRrvaphALSEEEKTTLRAGLI 95
Cdd:smart00913   1 AEKQLEQFQKSPGFWLLLLEILANSE-DQYVRQLAAITLKNKITRRWS-----SLPEEEKEEIKNSLL 62
 
Name Accession Description Interval E-value
CSE1 COG5657
CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning]; ...
10-980 1.72e-49

CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning];


Pssm-ID: 227944 [Multi-domain]  Cd Length: 947  Bit Score: 190.02  E-value: 1.72e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966947066  10 VLQVLTQATSQDTAVLKPAEEQLKQWETQPGFYSVLLNIFTNHTLDINVRWLAVLYFKHGIDRYWRRVAPHALSEEEKTT 89
Cdd:COG5657    6 VVKQLDLAQSPDPPSVKCAEERLRQWEKQHGFALKLLSINLSAFNSMSLRWAALIQFKNYIDKHWREENGNSILPDENVL 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966947066  90 LRAGLITNFNEPINQIATQIAVLIAKVARLDCPRQWPELIPTLIESVKVQDDLRQHRALLTFYHVTKTLAskRLAADRKL 169
Cdd:COG5657   86 IRDELFSLIISSSNQLQIQNALAVSRIARLDFPDEWPTLVPDLLSLLSEKDMVTNENSLRVLHHIFKRLR--RLFRSDAL 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966947066 170 FYDLASGIYNFACSLWNHHTDTFLQqvSSGNEAVILSSLERTLlslKVLRKLTVNGFVEPHKNME-----VMGFLHGIFE 244
Cdd:COG5657  164 FLEIAPVLLSILCPFLFSSAYFWSM--SENLDESLLSLFQVCL---KLIRRYYDLGFQDIPEFFEdnldkFMEHFCKLLS 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966947066 245 RLKQFLE--CSRSIGTDNVCRDRLEkTIILFTKVLLDFLDQHPFSFTPLIQRSLEfsvSYVFTEVGEGVTFERFIVqCMN 322
Cdd:COG5657  239 YSNPVLQkdCLEDCVYFKLKGSICE-IFNLYTTKYPEVITYLIYDFVEIVWNLLT---TITRPYIRDYLVSKSLTV-LIN 313
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966947066 323 LIKMIVKNYAYKPSKNFEDSSPETLEAhkikmafftyptlteicrrLVSHYFLLTEEELTMWEEDPEGFTVEETGGDSwK 402
Cdd:COG5657  314 VIKYPIRKTAEVLSNVSENLINNLVDL-------------------LILPNLILREEDLEEWEDDPLEYIREQSKTDY-E 373
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966947066 403 YSLRPCTEVLFIDIFHEYNQTLTPVLLEMMQtlQGPTNVEDMNALLIKDAVYNAVGLAAYELFDSVDFDQWFKNQLLPEL 482
Cdd:COG5657  374 VNVRPCIENELKDLFDVFGRIAVGHELTVIE--SEATTPNILDEARQLFAAYASFGLGVEAVNRMVDFVKFLGSIIYPDL 451
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966947066 483 ----QVIHNRYkpLRRRVIWLIGQWISVK--FKSDLRPMLYEAICNLLQDQDLVIQIYFDRTYVFSIFlncaspvDDFEF 556
Cdd:COG5657  452 lspnEIIHLRI--LRSRIAYILTFRNQLDssELSESKFLASQFFVNYTTACIDAVVLLTTREAYSTIF-------DDWNF 522
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966947066 557 RTDQFLPYLETMFTLLFQLLQQVTECDTKMHVLHVLSCVIERVNMQIRPYVGCLVQYLPLLWKQSEEhNMLRCAILTTLI 636
Cdd:COG5657  523 SVCSKIGLLENLILLVLSLMASPSSLEEREFLLQLISRIIIIDPELIAPLGSEILQLLDNLVEINAK-NPSNPQFAHYTF 601
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966947066 637 HLVQGLGADSKNLYPFLLPVIQLStdVSQPPHVYLLEDGLELWLVtlenspcitpellrIFQNMSPLLELSS-ENLRTCF 715
Cdd:COG5657  602 EDIGALVFLKSGMCEITIPTLVLA--LVPEFPVLLSEDATELWSY--------------VLQLLSILPEHFSgDVLPSVV 665
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966947066 716 KIIngYIFLSSTEFLQTyAVGLCQSFCELLKEITTEGQ-------VQVLKVVENALKVNP------ILGPQMFQPILPYV 782
Cdd:COG5657  666 KIL--RQPSLATELLPT-KLEILKSYRLLDNPILTTGYifkssgfQPVLGILQYLLGSEPhdalcfLNLTVVETLYLENI 742
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966947066 783 FKGIIEGERYPVVMSTYLGVMGRVLLQNTSFFSSLLN---------EMAHKFNQEMDQLLGNMIEMWVDRMDNITQPERR 853
Cdd:COG5657  743 YEPYVNLIFVLLLSRLKNSKTERFVIKIIHVFSLVSFkdsltvgcdNLISKINQTKNILIVQLYGNWILGFDEIHDSKDR 822
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966947066 854 KLSALaLLSLLPSDNSVIQDKFCGIINISVEglhdVMTEDPETGTyKDCMLmSHLEEPKVTE--DEEPPTEQDKRKKMLA 931
Cdd:COG5657  823 KIHLI-GLSNLLRTLHPEVLSYVSVTNLIIS----LLSEIFETAS-GDAII-YELNDDYADDwfDGEISAEEFSRLAQLE 895
                        970       980       990      1000      1010
                 ....*....|....*....|....*....|....*....|....*....|..
gi 966947066 932 LK-DPVHMVSL-QQFIYEKLKAQQEMLG-EQGFQSLMETVDTEIVTQLQEFL 980
Cdd:COG5657  896 FKvDPVHDIDNtKYFISFFMEAMNSNLGnENEIVFRLPTENQSLLEQLQEKL 947
IBN_N pfam03810
Importin-beta N-terminal domain;
28-100 1.55e-17

Importin-beta N-terminal domain;


Pssm-ID: 397745 [Multi-domain]  Cd Length: 72  Bit Score: 77.66  E-value: 1.55e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966947066   28 AEEQLKQWETQPGFYSVLLNIFTNHTLDINVRWLAVLYFKHGIDRYWRRVApHALSEEEKTTLRAGLITNFNE 100
Cdd:pfam03810   1 AEKQLEQFEKSPGFWSKLLQILSNSENPLEVRQLAALYLKNLITRHWEEEK-NSLPPEEKEQIKNNLLNLLGS 72
IBN_N smart00913
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ...
28-95 1.33e-12

Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport.


Pssm-ID: 197981 [Multi-domain]  Cd Length: 67  Bit Score: 63.42  E-value: 1.33e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966947066    28 AEEQLKQWETQPGFYSVLLNIFTNHTlDINVRWLAVLYFKHGIDRYWRrvaphALSEEEKTTLRAGLI 95
Cdd:smart00913   1 AEKQLEQFQKSPGFWLLLLEILANSE-DQYVRQLAAITLKNKITRRWS-----SLPEEEKEEIKNSLL 62
SXM1 COG5656
Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, ...
8-658 2.31e-11

Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227943 [Multi-domain]  Cd Length: 970  Bit Score: 67.96  E-value: 2.31e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966947066   8 TVVLQVLTQATSQDTAVLKPAEEQLKQWETQPGFYSVLLNIFTNHTLDINVRWLAVLYFKHGIDRYWRRVAPHALSEEEK 87
Cdd:COG5656    3 EELLQCFLQTLDADAGKRTIAEAMLKDLEKQPGFVMALLHICSKDEGDLNVKLSAAIYFKNKIIRSWSSKRDDGIKADEK 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966947066  88 TTLRAGLITNF-----NEPINQIATQIAVLIAkVARLDCPRQWPELIPTLIESVKVQDDLRQHRALLTFYHVTKTLASKR 162
Cdd:COG5656   83 SEAKKYLIENIldvflYSPEVTRTALNAILVN-IFSEDKPSDLWGLFPKAANLLRSSEANHVYTGLLCLEELFKAYRWKY 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966947066 163 LAADRKL------FYDLASGIYNFACSLWNHHTDTFLQQVSSGNEAVILSSLERTL-----------LSLKVLRKLTVNG 225
Cdd:COG5656  162 NDEQVDIlmlitaLFPILEKVGGNLESQGNYGSVETLMLILKSFKSVCYYSLPDFLsaietfsswfqLSLRILQKPLPNE 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966947066 226 FVE-------PHKNMEVMGFLHGIFERLkqfleCSRSIGTDNVCRDRLEKTIIL--FTKVLLDFLDQHPFSFTP---LIQ 293
Cdd:COG5656  242 VLSldpevrsLSKWVKCKKWAAYNLYRS-----FQRYIKKSYKKSYLSFYITFMtrVPMILATFFKQIEEWGQGqlwLSD 316
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966947066 294 RSLEFSVSyvftevgegvtferFIVQCMNlikmivknyaykpsknfEDSSPETLEAH-KIKMAFFTYPTLTeicrrlvsh 372
Cdd:COG5656  317 IELYFIDF--------------FVELCVD-----------------ADQTWRLMEPHlQYIISGVIFPLLC--------- 356
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966947066 373 yflLTEEELTMWEEDPEGFTVEETggDSWKYSLRPCTEVLFIDIFHEYNQ---TLTPVLLEMMQTL----QGPTNVEdmN 445
Cdd:COG5656  357 ---LSEEEEELFENDPDEYIRRYY--DFFDNGLSPDLAALFFLIISKSKRkeeTFQGILSFLLSILgqsaATPSNID--N 429
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966947066 446 ALLIKDAVYNAVGLAAYELFDSV---DFDQWFKNQLLPELQvihNRYKPLRRRVIWLIGQwISVKFK-SDLRPMLYEAIC 521
Cdd:COG5656  430 ARQAEGALRLLASIKSFITKMSPaanVMEYFIVNHVIPAFR---SNYGFLKSRACEFIST-IEEDFKdNGILLEAYENTH 505
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966947066 522 NLLQDQDLVIQIYFDRTYVFSIFLNCASPVddfefrTDQFLPylETMFTLLFqlLQQVTECDTkmhVLHVLSCVIERVNM 601
Cdd:COG5656  506 NCLKNNHLPVMIEAALALQFFIFNEQSHEK------FSAHVP--ETMEKLLS--LSNTFEIDP---LSMVMESFVEYFSE 572
                        650       660       670       680       690       700       710
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966947066 602 QIRPY----VGCLVQYL-----------PLLWKQSEEHNMLRCAILTTLIHLVQGLGADS---KNLYPFLLPVIQ 658
Cdd:COG5656  573 ELSPFapelAGSLVRQFlkiaqsllensSDTSSVVDDKQMAASGILRTIESMILSLENRPlvlKYLEVSLYPVIS 647
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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