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Conserved domains on  [gi|966945384|ref|XP_014994857|]
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pleiotropic regulator 1 [Macaca mulatta]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 196-490 1.44e-88

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 273.44  E-value: 1.44e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966945384 196 LYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDL 275
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966945384 276 EYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIR 355
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966945384 356 LWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDN-IKQWKFPDGSFIQNLSGHNAIINTLTVNSDG-VLVSGADN 433
Cdd:cd00200  161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGtIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGyLLASGSED 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 966945384 434 GTMHLWDWRTGYNFQRVHAavqpgsldSESGIFACAFDQSESRLLTAEADKTIKVYR 490
Cdd:cd00200  241 GTIRVWDLRTGECVQTLSG--------HTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 196-490 1.44e-88

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 273.44  E-value: 1.44e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966945384 196 LYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDL 275
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966945384 276 EYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIR 355
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966945384 356 LWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDN-IKQWKFPDGSFIQNLSGHNAIINTLTVNSDG-VLVSGADN 433
Cdd:cd00200  161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGtIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGyLLASGSED 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 966945384 434 GTMHLWDWRTGYNFQRVHAavqpgsldSESGIFACAFDQSESRLLTAEADKTIKVYR 490
Cdd:cd00200  241 GTIRVWDLRTGECVQTLSG--------HTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
195-490 4.08e-69

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 227.10  E-value: 4.08e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966945384 195 KLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWD 274
Cdd:COG2319  111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966945384 275 LEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTI 354
Cdd:COG2319  191 LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTV 270

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966945384 355 RLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDN-IKQWKFPDGSFIQNLSGHNAIINTLTVNSDG-VLVSGAD 432
Cdd:COG2319  271 RLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGtVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGkTLASGSD 350

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 966945384 433 NGTMHLWDWRTGynfqrvhaaVQPGSLDSESG-IFACAFDQSESRLLTAEADKTIKVYR 490
Cdd:COG2319  351 DGTVRLWDLATG---------ELLRTLTGHTGaVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 pfam00400
WD domain, G-beta repeat;
194-232 1.79e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 53.12  E-value: 1.79e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 966945384  194 WKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWD 232
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 193-232 2.96e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 52.31  E-value: 2.96e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 966945384   193 PWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWD 232
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 192-358 4.34e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 49.12  E-value: 4.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966945384 192 PPwklyrVISGHLGWVRCIAVEP-GNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGV-----IVS---TRSPYLF 262
Cdd:PTZ00421  68 PP-----ILLGQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHtkkvgIVSfhpSAMNVLA 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966945384 263 SCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAvATVRCQAAE 342
Cdd:PTZ00421 143 SAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASA-KSQRCLWAK 221

                        170       180
                 ....*....|....*....|..
gi 966945384 343 PQ--IIT----GSHDTTIRLWD 358
Cdd:PTZ00421 222 RKdlIITlgcsKSQQRQIMLWD 243
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 196-490 1.44e-88

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 273.44  E-value: 1.44e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966945384 196 LYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDL 275
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966945384 276 EYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIR 355
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966945384 356 LWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDN-IKQWKFPDGSFIQNLSGHNAIINTLTVNSDG-VLVSGADN 433
Cdd:cd00200  161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGtIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGyLLASGSED 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 966945384 434 GTMHLWDWRTGYNFQRVHAavqpgsldSESGIFACAFDQSESRLLTAEADKTIKVYR 490
Cdd:cd00200  241 GTIRVWDLRTGECVQTLSG--------HTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
195-490 4.08e-69

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 227.10  E-value: 4.08e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966945384 195 KLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWD 274
Cdd:COG2319  111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966945384 275 LEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTI 354
Cdd:COG2319  191 LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTV 270

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966945384 355 RLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDN-IKQWKFPDGSFIQNLSGHNAIINTLTVNSDG-VLVSGAD 432
Cdd:COG2319  271 RLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGtVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGkTLASGSD 350

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 966945384 433 NGTMHLWDWRTGynfqrvhaaVQPGSLDSESG-IFACAFDQSESRLLTAEADKTIKVYR 490
Cdd:COG2319  351 DGTVRLWDLATG---------ELLRTLTGHTGaVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
190-443 2.99e-64

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 214.39  E-value: 2.99e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966945384 190 WHPP-WKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDK 268
Cdd:COG2319  147 WDLAtGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADG 226

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966945384 269 QVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITG 348
Cdd:COG2319  227 TVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASG 306

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966945384 349 SHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDN-IKQWKFPDGSFIQNLSGHNAIINTLTVNSDG-V 426
Cdd:COG2319  307 SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGtVRLWDLATGELLRTLTGHTGAVTSVAFSPDGrT 386

                        250
                 ....*....|....*..
gi 966945384 427 LVSGADNGTMHLWDWRT 443
Cdd:COG2319  387 LASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
187-498 4.39e-62

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 208.61  E-value: 4.39e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966945384 187 KPQWHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGE 266
Cdd:COG2319   61 LLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSA 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966945384 267 DKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQII 346
Cdd:COG2319  141 DGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLA 220

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966945384 347 TGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDN-IKQWKFPDGSFIQNLSGHNAIINTLTVNSDG 425
Cdd:COG2319  221 SGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGtVRLWDLATGELLRTLTGHSGGVNSVAFSPDG 300

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966945384 426 -VLVSGADNGTMHLWDWRTGYNFQRVHAavqpgsldSESGIFACAFDQSESRLLTAEADKTIKVYredDTATEE 498
Cdd:COG2319  301 kLLASGSDDGTVRLWDLATGKLLRTLTG--------HTGAVRSVAFSPDGKTLASGSDDGTVRLW---DLATGE 363
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 195-399 3.49e-54

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 184.08  E-value: 3.49e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966945384 195 KLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWD 274
Cdd:cd00200   84 ECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWD 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966945384 275 LEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVrcqAAEPQ---IITGSHD 351
Cdd:cd00200  164 LRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSV---AFSPDgylLASGSED 240

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 966945384 352 TTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDN-IKQWK 399
Cdd:cd00200  241 GTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGtIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
198-499 3.91e-54

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 187.43  E-value: 3.91e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966945384 198 RVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEY 277
Cdd:COG2319   30 LLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966945384 278 NKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLW 357
Cdd:COG2319  110 GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966945384 358 DLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDN-IKQWKFPDGSFIQNLSGHNAIINTLTVNSDG-VLVSGADNGT 435
Cdd:COG2319  190 DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGtVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGrLLASGSADGT 269

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966945384 436 MHLWDWRTGynfQRVHAAVQPGsldseSGIFACAFDQSESRLLTAEADKTIKVYredDTATEET 499
Cdd:COG2319  270 VRLWDLATG---ELLRTLTGHS-----GGVNSVAFSPDGKLLASGSDDGTVRLW---DLATGKL 322
WD40 COG2319
WD40 repeat [General function prediction only];
211-498 6.77e-45

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 162.77  E-value: 6.77e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966945384 211 AVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSA 290
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966945384 291 VYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTN 370
Cdd:COG2319   81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966945384 371 HKKSVRAVVLHPRHYTFASGSPDN-IKQWKFPDGSFIQNLSGHNAIINTLTVNSDG-VLVSGADNGTMHLWDWRTGYNFQ 448
Cdd:COG2319  161 HSGAVTSVAFSPDGKLLASGSDDGtVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGkLLASGSADGTVRLWDLATGKLLR 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 966945384 449 RVHAavqpgsldSESGIFACAFDQSESRLLTAEADKTIKVYredDTATEE 498
Cdd:COG2319  241 TLTG--------HSGSVRSVAFSPDGRLLASGSADGTVRLW---DLATGE 279
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 194-316 1.00e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 120.90  E-value: 1.00e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966945384 194 WKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCW 273
Cdd:cd00200  167 GKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVW 246

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 966945384 274 DLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWD 316
Cdd:cd00200  247 DLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 pfam00400
WD domain, G-beta repeat;
194-232 1.79e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 53.12  E-value: 1.79e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 966945384  194 WKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWD 232
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 193-232 2.96e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 52.31  E-value: 2.96e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 966945384   193 PWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWD 232
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 279-316 4.97e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 4.97e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 966945384   279 KVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWD 316
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
278-316 1.37e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.03  E-value: 1.37e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 966945384  278 NKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWD 316
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 192-358 4.34e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 49.12  E-value: 4.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966945384 192 PPwklyrVISGHLGWVRCIAVEP-GNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGV-----IVS---TRSPYLF 262
Cdd:PTZ00421  68 PP-----ILLGQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHtkkvgIVSfhpSAMNVLA 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966945384 263 SCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAvATVRCQAAE 342
Cdd:PTZ00421 143 SAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASA-KSQRCLWAK 221

                        170       180
                 ....*....|....*....|..
gi 966945384 343 PQ--IIT----GSHDTTIRLWD 358
Cdd:PTZ00421 222 RKdlIITlgcsKSQQRQIMLWD 243
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 235-274 6.43e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 6.43e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 966945384   235 SGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWD 274
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
323-358 8.43e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 8.43e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 966945384  323 VHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWD 358
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 319-358 1.06e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 1.06e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 966945384   319 TKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWD 358
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
236-274 2.25e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.56  E-value: 2.25e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 966945384  236 GKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWD 274
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 309-440 2.47e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.00  E-value: 2.47e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966945384 309 DSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQII-TGSHDTTIRLWDLVAGKTRVTLTNhkKSVRAVVLHPRHY-- 385
Cdd:PLN00181 554 EGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLaSGSDDGSVKLWSINQGVSIGTIKT--KANICCVQFPSESgr 631

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 966945384 386 TFASGSPD------NIKQWKFPDGSFIqnlsGHNAIINTLTVNSDGVLVSGADNGTMHLWD 440
Cdd:PLN00181 632 SLAFGSADhkvyyyDLRNPKLPLCTMI----GHSKTVSYVRFVDSSTLVSSSTDNTLKLWD 688
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 402-440 1.60e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 1.60e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 966945384   402 DGSFIQNLSGHNAIINTLTVNSDG-VLVSGADNGTMHLWD 440
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGkYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 225-359 1.63e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 44.31  E-value: 1.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966945384 225 DRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCG-EDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVL 303
Cdd:PLN00181 554 EGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGsDDGSVKLWSINQGVSIGTIKTKANICCVQFPSESGRSL 633

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 966945384 304 VTCSRDSTARIWDVRT-KASVHTLSGHTNAVATVRCqAAEPQIITGSHDTTIRLWDL 359
Cdd:PLN00181 634 AFGSADHKVYYYDLRNpKLPLCTMIGHSKTVSYVRF-VDSSTLVSSSTDNTLKLWDL 689
WD40 pfam00400
WD domain, G-beta repeat;
403-440 3.29e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 3.29e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 966945384  403 GSFIQNLSGHNAIINTLTVNSDG-VLVSGADNGTMHLWD 440
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGkLLASGSDDGTVKVWD 39
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 323-435 5.91e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 38.90  E-value: 5.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966945384  323 VHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKtrvtlTNHKKSVRAVVLHPRHYTFASGSPDNIkqwkfpd 402
Cdd:pfam20426 117 VQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVLRGR-----SSEKRSRNTQTEFPRKDHVIAETPFHI------- 184

                          90       100       110
                  ....*....|....*....|....*....|....
gi 966945384  403 gsfiqnLSGHNAIINTLTVNSD-GVLVSGADNGT 435
Cdd:pfam20426 185 ------LCGHDDIITCLYVSVElDIVISGSKDGT 212
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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