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Conserved domains on  [gi|966943483|ref|XP_014994018|]
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amphiregulin [Macaca mulatta]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA02887 super family cl31518
EGF-like protein; Provisional
 146-186 1.76e-07

EGF-like protein; Provisional


The actual alignment was detected with superfamily member PHA02887:

Pssm-ID: 165214  Cd Length: 126  Bit Score: 48.77  E-value: 1.76e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 966943483 146 CNAEFQNFCIHGECKYIEHLEAVTCKCQQEYFGERCGEKSM 186
Cdd:PHA02887  86 CKNDFNDFCINGECMNIIDLDEKFCICNKGYTGIRCDEVSI 126
PI3K_1B_p101 super family cl11126
Phosphoinositide 3-kinase gamma adapter protein p101 subunit; Class I PI3Ks are dual-specific ...
 52-117 3.96e-05

Phosphoinositide 3-kinase gamma adapter protein p101 subunit; Class I PI3Ks are dual-specific lipid and protein kinases involved in numerous intracellular signaling pathways. Class IB PI3K, p110gamma, is mainly activated by seven-transmembrane G-protein-coupled receptors (GPCRs), through its regulatory subunit p101 and G-protein beta-gamma subunits.


The actual alignment was detected with superfamily member pfam10486:

Pssm-ID: 463109  Cd Length: 860  Bit Score: 44.29  E-value: 3.96e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966943483   52 TSRSEMSSGSEISPVSEMPSSSELSSGVDYDYSEEYDNEPqipgyivDDSVRVEQVVKPPKNKTES 117
Cdd:pfam10486 355 SSTDSMFSTLSLSSSSLTPSVSSLSSGVDSDYCEDSDESS-------SSSPRAEKPREKSKKKSRS 413
 
Name Accession Description Interval E-value
PHA02887 PHA02887
EGF-like protein; Provisional
 146-186 1.76e-07

EGF-like protein; Provisional


Pssm-ID: 165214  Cd Length: 126  Bit Score: 48.77  E-value: 1.76e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 966943483 146 CNAEFQNFCIHGECKYIEHLEAVTCKCQQEYFGERCGEKSM 186
Cdd:PHA02887  86 CKNDFNDFCINGECMNIIDLDEKFCICNKGYTGIRCDEVSI 126
PI3K_1B_p101 pfam10486
Phosphoinositide 3-kinase gamma adapter protein p101 subunit; Class I PI3Ks are dual-specific ...
 52-117 3.96e-05

Phosphoinositide 3-kinase gamma adapter protein p101 subunit; Class I PI3Ks are dual-specific lipid and protein kinases involved in numerous intracellular signaling pathways. Class IB PI3K, p110gamma, is mainly activated by seven-transmembrane G-protein-coupled receptors (GPCRs), through its regulatory subunit p101 and G-protein beta-gamma subunits.


Pssm-ID: 463109  Cd Length: 860  Bit Score: 44.29  E-value: 3.96e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966943483   52 TSRSEMSSGSEISPVSEMPSSSELSSGVDYDYSEEYDNEPqipgyivDDSVRVEQVVKPPKNKTES 117
Cdd:pfam10486 355 SSTDSMFSTLSLSSSSLTPSVSSLSSGVDSDYCEDSDESS-------SSSPRAEKPREKSKKKSRS 413
 
Name Accession Description Interval E-value
PHA02887 PHA02887
EGF-like protein; Provisional
 146-186 1.76e-07

EGF-like protein; Provisional


Pssm-ID: 165214  Cd Length: 126  Bit Score: 48.77  E-value: 1.76e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 966943483 146 CNAEFQNFCIHGECKYIEHLEAVTCKCQQEYFGERCGEKSM 186
Cdd:PHA02887  86 CKNDFNDFCINGECMNIIDLDEKFCICNKGYTGIRCDEVSI 126
PI3K_1B_p101 pfam10486
Phosphoinositide 3-kinase gamma adapter protein p101 subunit; Class I PI3Ks are dual-specific ...
 52-117 3.96e-05

Phosphoinositide 3-kinase gamma adapter protein p101 subunit; Class I PI3Ks are dual-specific lipid and protein kinases involved in numerous intracellular signaling pathways. Class IB PI3K, p110gamma, is mainly activated by seven-transmembrane G-protein-coupled receptors (GPCRs), through its regulatory subunit p101 and G-protein beta-gamma subunits.


Pssm-ID: 463109  Cd Length: 860  Bit Score: 44.29  E-value: 3.96e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966943483   52 TSRSEMSSGSEISPVSEMPSSSELSSGVDYDYSEEYDNEPqipgyivDDSVRVEQVVKPPKNKTES 117
Cdd:pfam10486 355 SSTDSMFSTLSLSSSSLTPSVSSLSSGVDSDYCEDSDESS-------SSSPRAEKPREKSKKKSRS 413
PHA03099 PHA03099
epidermal growth factor-like protein (EGF-like protein); Provisional
 146-181 5.30e-03

epidermal growth factor-like protein (EGF-like protein); Provisional


Pssm-ID: 165381  Cd Length: 139  Bit Score: 36.15  E-value: 5.30e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 966943483 146 CNAEFQNFCIHGECKYIEHLEAVTCKCQQEYFGERC 181
Cdd:PHA03099  45 CGPEGDGYCLHGDCIHARDIDGMYCRCSHGYTGIRC 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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