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Conserved domains on  [gi|1622939571|ref|XP_014993830|]
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protein furry homolog-like isoform X5 [Macaca mulatta]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Fry_C pfam19421
Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a ...
 2376-3099 0e+00

Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity. This domain binds to polo-like kinase 1 (Plk1) through the polo-box domain (PBD) of Plk1 in a manner dependent on the cyclin-dependent kinase 1-mediated Fry phosphorylation, promoting Plk1 activity during early mitosis. Fry also binds to Aurora A and may function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation.


:

Pssm-ID: 466072  Cd Length: 633  Bit Score: 1064.37  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 2376 VSKELPGKTLDFHFDISETPIIGNKYGDQHSAAGRNGKPKVIAVTRSTSSTSSGSNSNALVPVSWKRPQLSQRRTREKLM 2455
Cdd:pfam19421    1 SSKELPGKTLDFHFDISETPIIGRRYDELHGSAGRDGKPRVIAVTRSTSSTSSGSNSNVLVPVSWKRPQLSQKRTREKLV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 2456 NVLSLCGPESGLPKNPSVVFSSNEDLEVGDQQTSLISTtEDIIQEEEVaVEDNSSEQQFGVFKDFDFLDVELEDAEGESM 2535
Cdd:pfam19421   81 NVLSLCGQEVGLTKNPSVIFSSCGDLDLMDQQTSLVSS-EDGIREEEN-MDDTTSEQQFRVFRDFDFLDVELEDGEGESM 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 2536 DNFNWGVRRRSLDSIDKGDTPSLQEYQCSSSTPSLNLTNQEDTDESSEEEAaLTASQILSRTQMLNSDSATDEtmPDHPD 2615
Cdd:pfam19421  159 DNFNWGVRRRSLDSLDKGDTPSLEESQLSGSTPSLNLTNHEDSDESSEEES-LTASQILSHSQLLNSDSPTEE--PNHVD 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 2616 LLLQSQDSigSITTEEMLqiRDETPTLEASLdnansqlPEDTSSVlkeehvttfedegsyiiqeqqdslvcqgildleet 2695
Cdd:pfam19421  236 SLSQSQDS--SSADEESL--RAETPSLEVSL-------PEDASAR----------------------------------- 269

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 2696 empeplapesypesiceedvtlalkelderceeeeadfsglssqdeeeqdGFPEVQTSPLPSPFLSAIIAAFQPVAYDDE 2775
Cdd:pfam19421  270 --------------------------------------------------GFPEIQSSPPPSPFFSAILAAFQPVVCDDA 299

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 2776 EEAWRCHVNQMLSDTDGSSAVFTFHVFSRLFQTIQRKFGEITNEAVSFLGESLQRIGTKFKSSLEVMMICSECPTVFVDA 2855
Cdd:pfam19421  300 EEAWRCHVNQLVSDSDGSCAVYTFHVFSSLFQNIQRKFCSLTCDAVSYLGDSLRGIGSKFLSSSQMLTSCSECPTLFVDA 379

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 2856 ETLMSCGLLETLKFGVLELQEHLDTYNAKREATEQWLDDCKRTFGAKED--MYRINTDAQE---LELCRRLYKLHFQLLL 2930
Cdd:pfam19421  380 ETLMSCGLLEKLKFSVLELQEYLDTYNNKKEAAESWLDNCKATFPRGSGdgVITCQPADQEekqLELCQRLYKLHFQLLL 459

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 2931 LFQAYCKLINQVNTIKNEAEVINMSEELAQLESILKEAESVSEN-----EEIDISKAAQTTIETAIHSLIETLKNKEFIS 3005
Cdd:pfam19421  460 LFQSYCKLIGQVHAISSVPELINMSEELAQLESSLKEAEASVTSdelaqEESASSEPSFSSSEAAVQSILESLRNKEFST 539

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 3006 AVVQVKAFRSLWPSDIFGSCEDDPVQTLLHIYFHHQTLGQTGSFAVIGSNLDMSEANYKLMELNLEIRESLRMVQSYQLL 3085
Cdd:pfam19421  540 AIRQIKECRSLWPNDIFGSSSEDEVQTLLNIYFRHQTLGQTGTFALVGSNQDLSEICSKLMELNLEIRDMIRRAQGYRAL 619

                          730
                   ....*....|....
gi 1622939571 3086 AQPKPMGNMVSTGF 3099
Cdd:pfam19421  620 TAFLPDSSVSGSSL 633
MOR2-PAG1_N pfam14222
Cell morphogenesis N-terminal; This family is the conserved N-terminal region of proteins that ...
 209-741 0e+00

Cell morphogenesis N-terminal; This family is the conserved N-terminal region of proteins that are involved in cell morphogenesis.


:

Pssm-ID: 464107  Cd Length: 554  Bit Score: 630.38  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571  209 ERRDLAVDFIFCLVLVEVLKQIPVHPVPDPLVHEVLNLAFKHFKHKEGYSGTNTGNVHIIADLYAEVIGVLAQSKFQAVR 288
Cdd:pfam14222    1 ERKSLASIYILCRVLIEIVKQSPLDALTEELGDKLEEIVFGQLKTADPDQLSSSPNRSANWNLFAELLGVLSEIRFVSVS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571  289 KKFVTELKELRQKEQSPHVVQSVISLIMGMKFFRVKMYPVEDFEASFQFMQECAQYFLEVKDKDIKHALAGLFVEILIPV 368
Cdd:pfam14222   81 DRFIAELEKLPKGLSSKDLEAKIELLIRGMRYLRIKVYPEEAFEESADFMQSLAKFFLNAHGQRVKHAYAEVLVELLLPV 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571  369 AATVKNEVNVPCLKNFVEMLYQTTFELSSRKKHSLALYPLITCLLCVSQKQFFLNNWHIFLQNCLSHLKNKdpKMSRVAL 448
Cdd:pfam14222  161 AATATAEVNHPKWKEAVELLYPRAAKMASKPRHWNVAFPLVTTLLCVSPKEFFLSNWLSLIESLISKLKDK--TTRPVAL 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571  449 ESLYRLLWVYVIRIKcESNTVTQSRLMSIVSALFPKGSRSVVPRDTPLNIFVKIIQFIAQERLDFAMKEIIFDLLSVG-- 526
Cdd:pfam14222  239 QGLSRLLWVYLYRCT-ESLNTTTRKLESILKLLFPPGKKTWLPADPPLDPLVQIIRFIGFKHPDFCFENIIFPLLNADlf 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571  527 KSTKTFTINPERMNIGLRVFLVIADSLQQKDGEPPMPTTGVILPSGN--TLRVKKIFLNKTlTDEEAKVIGMSVYYPQVR 604
Cdd:pfam14222  318 NGLKLENLNPERMIIGIRAFLAILSDLEKGEQRPPFPQSFGTLPSPSssALRSKEENLSRP-VDTLALSEGIKDYYERFC 396

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571  605 KALDSILRHLDKEVGRPM-------------CMTSVQMSNKEPED-MITGERKPKIDLFRTCIAAIPRLIPDGMSRTDLI 670
Cdd:pfam14222  397 KILGKILILCDNTFGGQAvldekfssptpktPISETFNFSRRPDDnAYDGQRQPFYELLHTAVQAIPRCLPSSIPFNSLI 476

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571  671 ELLARLTIHMDEELRALAFNTLQALMLdfPDWREDVLSGFVYFIV---------REVTDIHPTLLDNAVKMLVQLINQWK 741
Cdd:pfam14222  477 ELLCRGTVHVDPNIAESAAQALKRIAR--PSHAQQVITGFARFIFnfddrystmSDGGMLGPGHIESLLKLYVELLEIWI 554
MOR2-PAG1_C pfam14225
Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that ...
 2093-2346 2.03e-75

Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that are involved in cell morphogenesis.


:

Pssm-ID: 464109  Cd Length: 252  Bit Score: 252.01  E-value: 2.03e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 2093 ATIFWIAASLLESDYEYEYLLALRLLNKLLIHLPLDKSESREKIENVQSKlKWTN-FPGLQQLFLKGFTSASTQEMTVHL 2171
Cdd:pfam14225    1 PQLFWTTVACLETIHEHEFLEALRLLEKLLDKLDLDDPDVVEKLLSSQPQ-KWEGkFEGLQPLLLKGLRSSVTLEPTLKL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 2172 LSKLISVSKHTLVDPSQlSGFPLNILCLLPHLIQHFDSP--TQFCKETASRIAKVCAEEKCPtlvNLAHMMSLYSTHTYs 2249
Cdd:pfam14225   80 LDRLTKLPDDRLVGPSD-SRLLFLVLANLPRFLHALDDPdiDPDCIETAENLAELAEEQGLP---SLARVLTSYAKGRF- 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 2250 RDCSNWINVVCRYLHDSFS-DTTFNLVTYLAELLEKGLSSMQQSLLQIIYSLLSHIDLSAAPAKQFNLEIIKIIGKYVQS 2328
Cdd:pfam14225  155 RTSDDFLKQVVSYLREAYFpDYEFQMLTFLLGLLTNGPPWVKVKTLQILKVLLPEIDMRRPEIAGHGADLISPLLRLLQT 234

                          250
                   ....*....|....*...
gi 1622939571 2329 PYWKEALNILKLVVSRSA 2346
Cdd:pfam14225  235 DLCMQALEVLDEIVTISG 252
MOR2-PAG1_mid super family cl20509
Cell morphogenesis central region; This family is the conserved central region of proteins ...
 773-1951 6.09e-36

Cell morphogenesis central region; This family is the conserved central region of proteins that are involved in cell morphogenesis.


The actual alignment was detected with superfamily member pfam14228:

Pssm-ID: 433790 [Multi-domain]  Cd Length: 1113  Bit Score: 150.56  E-value: 6.09e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571  773 SNVFHV--VEGFALVILCSSRPATRKLAVSVLREIRALFALLEIPKGDDELAIDVMDRLSPSILESFIHLTGADQTTLLY 850
Cdd:pfam14228    1 TNEFRPsgLDAVGLIFLSSVDVQIRHTALELLRCVRALYNDLRDMSSKERSDVSWKNNKEPIFIIDVFEENGDDIVQQCY 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571  851 CPSSIDLQTLAEWNSSPISHQFDVISPShiwifahvtQGQDPWIISLSSFLKQENlpKHCSTAVSYAWMFAYTRLQLLSP 930
Cdd:pfam14228   81 WDSGRPYDMRRESDAIPPDLTLQSILES---------PDKGRWARCLSELVKYAA--ELCPSSVQEARLEVVQRLAQITP 149

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571  931 qVDINSpinakKVNTTTSSDSYIGLWRNYLILCCSaatsssstsagsvrCsPPETlasTPDSGYSidskiigipSPSSLF 1010
Cdd:pfam14228  150 -VELGG-----KAHQSQDADNKLDQWLLYSMFACS--------------C-PPDD---VEDTKSH---------SAKELY 196

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 1011 KHIVPMMRSESMEITESLVLGLGRTNPGAFRELIEELHPIIKEA---LERRPENMKRRRRRDILRVQLVRIFELLAD--- 1084
Cdd:pfam14228  197 HLIFPSLKSGSETHIHAATLALGHSHLEVCEPMFGELRSFLDEVateTESKPKWKSQKARREELRVHVANIYRMVAEnfw 276

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 1085 AGVISHSASGGLdnetHFLNntLLEyvDLTRQLLEAENEKDSDtLKDIRCHFSALVANIIQNVpVHQRRSIFPQQSlRHS 1164
Cdd:pfam14228  277 PGMLIRKPVFRL----HVLK--FIE--DTVRYITTSPLENFQD-LQPLRFALASVLRSLAPEF-VKSKSERFDPRT-RKR 345

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 1165 LFMLFSHWAGPFSIMFT---------PLDRYS------------------DRNMQINRHQYCALKAMSAVLCcGPVADNV 1217
Cdd:pfam14228  346 LFDLLASWCDDTGTVWSqdgvsdyrrEVERYKssqnsrskdsvdkisfdkEVNEQVEAIQWIAMNAMAALLY-GPCFDDN 424

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 1218 GLSSDGYLYKWLDNILD------------------------------SLDKKVHQLGCEAVTL-------LLELNPDqsn 1260
Cdd:pfam14228  425 ARKMSGRVIAWINGLFLepaprapfgyspadprtpsyskfagegvrgLGGKDRHRGGPLRVHLakvalknLLQTNLD--- 501

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 1261 LMYWAVDRCYTGSRRVAAGCFKAIANVFQNRDY-QFDTVMLLNLILFKAADSSRSIYEVAMQLLQILEPKmfRYAHKLEV 1339
Cdd:pfam14228  502 LFPACIDQCYSSDASIADGYFSVLAEVYMRQEIpRCDIQRLLSLILYKVVDPSRRIRDDALQMLETLSVR--EWAEDGEE 579

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 1340 QRTDGVLSQLSPLPHLYSVSYYQLSEELARAYPELTLAIFSEISQRIQTA--HPAGRQVmLHYLLPWMNNIELVDLKplp 1417
Cdd:pfam14228  580 GTGRYRAAVVGNLPDSYQQFQYKLSAKLAKDHPELSELLCEEIMQRQLDAvdIIAQHQV-LTCMAPWIENLNFLKLW--- 655

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 1418 tarrhdededDSlkdrelmvtsrrwlrgeGWgspqaTAMVLNNLMYMTAKYGDELAwSEVENVWTTLADGwPKNLKIILH 1497
Cdd:pfam14228  656 ----------ES-----------------GW-----SERLLKSLYYVTWRHGDQFP-DEIEKLWRTIASK-PRNISPVLD 701

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 1498 FLIS--ICGVNSEPS---------LLPYVKKVIVYLGRDKTMQLLEELVSEL------QLTDPVSSGVTHMDnppyyrIT 1560
Cdd:pfam14228  702 FLISkgIEDCDSNASaeitgafatYFSVAKRVSLYLARICPQQTIDHLVYELaqrmleESVEPSRPSDGAFD------LE 775

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 1561 SSYKIPSVTSGTTSSSNTMVAPtdgNPDNKPikenieesyvhLDIYSGLNSHLNRQHHRLesryssssGGSYEEEKSDSM 1640
Cdd:pfam14228  776 SSAVLEFSQGPAPVQVAQLLDP---QPHMSP-----------LLVRSSLEGPLRNASGSL--------SWRTVTGRSMSG 833

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 1641 PLYSNWRLKVMEHNQGE-------PLPFPPAGGcwsPLV-------------------DYVPETSSPG------------ 1682
Cdd:pfam14228  834 PLNTMPEVVAVDTHTGRsgqlftgSGPLPNMSG---PLMgvrsstgslrshhvsrdsgDYFIDTPNSVeeiritpvvnas 910

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 1683 -----LPLH-----RCNIAVILLTDliIDHSVKVEWGSYLHLLLHAIFIGFDHCHPEVYEHCKRLLLHLLIVMGpksnir 1752
Cdd:pfam14228  911 elqsaLQGHqhwlsRADIALILLAE--IAYENDEDFRSHLPLLFHVTFVSMDSSEDIVLKHCQHLLVNLLYSLA------ 982

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 1753 tvasvllrnkefnePRVLTVKQVAHLDYnftagindfipdyqpspmtdsglsssstsssislgnnsaaishlhttilnev 1832
Cdd:pfam14228  983 --------------GRHLELYDVEHGDG---------------------------------------------------- 996

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 1833 disvEQDGKVKTLMEFITSRKRGPLWNHEDVSAKNPSIKSAEQLTTFLKHVVsvfkqsssEAIHLEHHLSEV----ALQT 1908
Cdd:pfam14228  997 ----EYKQQVVSLIKYVQSKRGSRMWENEDMTLTRTELPSAALLSALVLSMV--------DAIFFQGDLREKwgeeALKW 1064

                         1290      1300      1310      1320
                   ....*....|....*....|....*....|....*....|...
gi 1622939571 1909 ALSCSSRHYAGRSFQIFRALKQPLTATTLSDVLSRLVETVGDP 1951
Cdd:pfam14228 1065 AMECTSRHLACRSHQIYRALRPSVTSDTCVSLLRCLHRCLGNP 1107
 
Name Accession Description Interval E-value
Fry_C pfam19421
Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a ...
 2376-3099 0e+00

Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity. This domain binds to polo-like kinase 1 (Plk1) through the polo-box domain (PBD) of Plk1 in a manner dependent on the cyclin-dependent kinase 1-mediated Fry phosphorylation, promoting Plk1 activity during early mitosis. Fry also binds to Aurora A and may function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation.


Pssm-ID: 466072  Cd Length: 633  Bit Score: 1064.37  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 2376 VSKELPGKTLDFHFDISETPIIGNKYGDQHSAAGRNGKPKVIAVTRSTSSTSSGSNSNALVPVSWKRPQLSQRRTREKLM 2455
Cdd:pfam19421    1 SSKELPGKTLDFHFDISETPIIGRRYDELHGSAGRDGKPRVIAVTRSTSSTSSGSNSNVLVPVSWKRPQLSQKRTREKLV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 2456 NVLSLCGPESGLPKNPSVVFSSNEDLEVGDQQTSLISTtEDIIQEEEVaVEDNSSEQQFGVFKDFDFLDVELEDAEGESM 2535
Cdd:pfam19421   81 NVLSLCGQEVGLTKNPSVIFSSCGDLDLMDQQTSLVSS-EDGIREEEN-MDDTTSEQQFRVFRDFDFLDVELEDGEGESM 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 2536 DNFNWGVRRRSLDSIDKGDTPSLQEYQCSSSTPSLNLTNQEDTDESSEEEAaLTASQILSRTQMLNSDSATDEtmPDHPD 2615
Cdd:pfam19421  159 DNFNWGVRRRSLDSLDKGDTPSLEESQLSGSTPSLNLTNHEDSDESSEEES-LTASQILSHSQLLNSDSPTEE--PNHVD 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 2616 LLLQSQDSigSITTEEMLqiRDETPTLEASLdnansqlPEDTSSVlkeehvttfedegsyiiqeqqdslvcqgildleet 2695
Cdd:pfam19421  236 SLSQSQDS--SSADEESL--RAETPSLEVSL-------PEDASAR----------------------------------- 269

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 2696 empeplapesypesiceedvtlalkelderceeeeadfsglssqdeeeqdGFPEVQTSPLPSPFLSAIIAAFQPVAYDDE 2775
Cdd:pfam19421  270 --------------------------------------------------GFPEIQSSPPPSPFFSAILAAFQPVVCDDA 299

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 2776 EEAWRCHVNQMLSDTDGSSAVFTFHVFSRLFQTIQRKFGEITNEAVSFLGESLQRIGTKFKSSLEVMMICSECPTVFVDA 2855
Cdd:pfam19421  300 EEAWRCHVNQLVSDSDGSCAVYTFHVFSSLFQNIQRKFCSLTCDAVSYLGDSLRGIGSKFLSSSQMLTSCSECPTLFVDA 379

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 2856 ETLMSCGLLETLKFGVLELQEHLDTYNAKREATEQWLDDCKRTFGAKED--MYRINTDAQE---LELCRRLYKLHFQLLL 2930
Cdd:pfam19421  380 ETLMSCGLLEKLKFSVLELQEYLDTYNNKKEAAESWLDNCKATFPRGSGdgVITCQPADQEekqLELCQRLYKLHFQLLL 459

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 2931 LFQAYCKLINQVNTIKNEAEVINMSEELAQLESILKEAESVSEN-----EEIDISKAAQTTIETAIHSLIETLKNKEFIS 3005
Cdd:pfam19421  460 LFQSYCKLIGQVHAISSVPELINMSEELAQLESSLKEAEASVTSdelaqEESASSEPSFSSSEAAVQSILESLRNKEFST 539

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 3006 AVVQVKAFRSLWPSDIFGSCEDDPVQTLLHIYFHHQTLGQTGSFAVIGSNLDMSEANYKLMELNLEIRESLRMVQSYQLL 3085
Cdd:pfam19421  540 AIRQIKECRSLWPNDIFGSSSEDEVQTLLNIYFRHQTLGQTGTFALVGSNQDLSEICSKLMELNLEIRDMIRRAQGYRAL 619

                          730
                   ....*....|....
gi 1622939571 3086 AQPKPMGNMVSTGF 3099
Cdd:pfam19421  620 TAFLPDSSVSGSSL 633
MOR2-PAG1_N pfam14222
Cell morphogenesis N-terminal; This family is the conserved N-terminal region of proteins that ...
 209-741 0e+00

Cell morphogenesis N-terminal; This family is the conserved N-terminal region of proteins that are involved in cell morphogenesis.


Pssm-ID: 464107  Cd Length: 554  Bit Score: 630.38  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571  209 ERRDLAVDFIFCLVLVEVLKQIPVHPVPDPLVHEVLNLAFKHFKHKEGYSGTNTGNVHIIADLYAEVIGVLAQSKFQAVR 288
Cdd:pfam14222    1 ERKSLASIYILCRVLIEIVKQSPLDALTEELGDKLEEIVFGQLKTADPDQLSSSPNRSANWNLFAELLGVLSEIRFVSVS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571  289 KKFVTELKELRQKEQSPHVVQSVISLIMGMKFFRVKMYPVEDFEASFQFMQECAQYFLEVKDKDIKHALAGLFVEILIPV 368
Cdd:pfam14222   81 DRFIAELEKLPKGLSSKDLEAKIELLIRGMRYLRIKVYPEEAFEESADFMQSLAKFFLNAHGQRVKHAYAEVLVELLLPV 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571  369 AATVKNEVNVPCLKNFVEMLYQTTFELSSRKKHSLALYPLITCLLCVSQKQFFLNNWHIFLQNCLSHLKNKdpKMSRVAL 448
Cdd:pfam14222  161 AATATAEVNHPKWKEAVELLYPRAAKMASKPRHWNVAFPLVTTLLCVSPKEFFLSNWLSLIESLISKLKDK--TTRPVAL 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571  449 ESLYRLLWVYVIRIKcESNTVTQSRLMSIVSALFPKGSRSVVPRDTPLNIFVKIIQFIAQERLDFAMKEIIFDLLSVG-- 526
Cdd:pfam14222  239 QGLSRLLWVYLYRCT-ESLNTTTRKLESILKLLFPPGKKTWLPADPPLDPLVQIIRFIGFKHPDFCFENIIFPLLNADlf 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571  527 KSTKTFTINPERMNIGLRVFLVIADSLQQKDGEPPMPTTGVILPSGN--TLRVKKIFLNKTlTDEEAKVIGMSVYYPQVR 604
Cdd:pfam14222  318 NGLKLENLNPERMIIGIRAFLAILSDLEKGEQRPPFPQSFGTLPSPSssALRSKEENLSRP-VDTLALSEGIKDYYERFC 396

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571  605 KALDSILRHLDKEVGRPM-------------CMTSVQMSNKEPED-MITGERKPKIDLFRTCIAAIPRLIPDGMSRTDLI 670
Cdd:pfam14222  397 KILGKILILCDNTFGGQAvldekfssptpktPISETFNFSRRPDDnAYDGQRQPFYELLHTAVQAIPRCLPSSIPFNSLI 476

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571  671 ELLARLTIHMDEELRALAFNTLQALMLdfPDWREDVLSGFVYFIV---------REVTDIHPTLLDNAVKMLVQLINQWK 741
Cdd:pfam14222  477 ELLCRGTVHVDPNIAESAAQALKRIAR--PSHAQQVITGFARFIFnfddrystmSDGGMLGPGHIESLLKLYVELLEIWI 554
MOR2-PAG1_C pfam14225
Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that ...
 2093-2346 2.03e-75

Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that are involved in cell morphogenesis.


Pssm-ID: 464109  Cd Length: 252  Bit Score: 252.01  E-value: 2.03e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 2093 ATIFWIAASLLESDYEYEYLLALRLLNKLLIHLPLDKSESREKIENVQSKlKWTN-FPGLQQLFLKGFTSASTQEMTVHL 2171
Cdd:pfam14225    1 PQLFWTTVACLETIHEHEFLEALRLLEKLLDKLDLDDPDVVEKLLSSQPQ-KWEGkFEGLQPLLLKGLRSSVTLEPTLKL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 2172 LSKLISVSKHTLVDPSQlSGFPLNILCLLPHLIQHFDSP--TQFCKETASRIAKVCAEEKCPtlvNLAHMMSLYSTHTYs 2249
Cdd:pfam14225   80 LDRLTKLPDDRLVGPSD-SRLLFLVLANLPRFLHALDDPdiDPDCIETAENLAELAEEQGLP---SLARVLTSYAKGRF- 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 2250 RDCSNWINVVCRYLHDSFS-DTTFNLVTYLAELLEKGLSSMQQSLLQIIYSLLSHIDLSAAPAKQFNLEIIKIIGKYVQS 2328
Cdd:pfam14225  155 RTSDDFLKQVVSYLREAYFpDYEFQMLTFLLGLLTNGPPWVKVKTLQILKVLLPEIDMRRPEIAGHGADLISPLLRLLQT 234

                          250
                   ....*....|....*...
gi 1622939571 2329 PYWKEALNILKLVVSRSA 2346
Cdd:pfam14225  235 DLCMQALEVLDEIVTISG 252
MOR2-PAG1_mid pfam14228
Cell morphogenesis central region; This family is the conserved central region of proteins ...
 773-1951 6.09e-36

Cell morphogenesis central region; This family is the conserved central region of proteins that are involved in cell morphogenesis.


Pssm-ID: 433790 [Multi-domain]  Cd Length: 1113  Bit Score: 150.56  E-value: 6.09e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571  773 SNVFHV--VEGFALVILCSSRPATRKLAVSVLREIRALFALLEIPKGDDELAIDVMDRLSPSILESFIHLTGADQTTLLY 850
Cdd:pfam14228    1 TNEFRPsgLDAVGLIFLSSVDVQIRHTALELLRCVRALYNDLRDMSSKERSDVSWKNNKEPIFIIDVFEENGDDIVQQCY 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571  851 CPSSIDLQTLAEWNSSPISHQFDVISPShiwifahvtQGQDPWIISLSSFLKQENlpKHCSTAVSYAWMFAYTRLQLLSP 930
Cdd:pfam14228   81 WDSGRPYDMRRESDAIPPDLTLQSILES---------PDKGRWARCLSELVKYAA--ELCPSSVQEARLEVVQRLAQITP 149

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571  931 qVDINSpinakKVNTTTSSDSYIGLWRNYLILCCSaatsssstsagsvrCsPPETlasTPDSGYSidskiigipSPSSLF 1010
Cdd:pfam14228  150 -VELGG-----KAHQSQDADNKLDQWLLYSMFACS--------------C-PPDD---VEDTKSH---------SAKELY 196

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 1011 KHIVPMMRSESMEITESLVLGLGRTNPGAFRELIEELHPIIKEA---LERRPENMKRRRRRDILRVQLVRIFELLAD--- 1084
Cdd:pfam14228  197 HLIFPSLKSGSETHIHAATLALGHSHLEVCEPMFGELRSFLDEVateTESKPKWKSQKARREELRVHVANIYRMVAEnfw 276

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 1085 AGVISHSASGGLdnetHFLNntLLEyvDLTRQLLEAENEKDSDtLKDIRCHFSALVANIIQNVpVHQRRSIFPQQSlRHS 1164
Cdd:pfam14228  277 PGMLIRKPVFRL----HVLK--FIE--DTVRYITTSPLENFQD-LQPLRFALASVLRSLAPEF-VKSKSERFDPRT-RKR 345

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 1165 LFMLFSHWAGPFSIMFT---------PLDRYS------------------DRNMQINRHQYCALKAMSAVLCcGPVADNV 1217
Cdd:pfam14228  346 LFDLLASWCDDTGTVWSqdgvsdyrrEVERYKssqnsrskdsvdkisfdkEVNEQVEAIQWIAMNAMAALLY-GPCFDDN 424

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 1218 GLSSDGYLYKWLDNILD------------------------------SLDKKVHQLGCEAVTL-------LLELNPDqsn 1260
Cdd:pfam14228  425 ARKMSGRVIAWINGLFLepaprapfgyspadprtpsyskfagegvrgLGGKDRHRGGPLRVHLakvalknLLQTNLD--- 501

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 1261 LMYWAVDRCYTGSRRVAAGCFKAIANVFQNRDY-QFDTVMLLNLILFKAADSSRSIYEVAMQLLQILEPKmfRYAHKLEV 1339
Cdd:pfam14228  502 LFPACIDQCYSSDASIADGYFSVLAEVYMRQEIpRCDIQRLLSLILYKVVDPSRRIRDDALQMLETLSVR--EWAEDGEE 579

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 1340 QRTDGVLSQLSPLPHLYSVSYYQLSEELARAYPELTLAIFSEISQRIQTA--HPAGRQVmLHYLLPWMNNIELVDLKplp 1417
Cdd:pfam14228  580 GTGRYRAAVVGNLPDSYQQFQYKLSAKLAKDHPELSELLCEEIMQRQLDAvdIIAQHQV-LTCMAPWIENLNFLKLW--- 655

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 1418 tarrhdededDSlkdrelmvtsrrwlrgeGWgspqaTAMVLNNLMYMTAKYGDELAwSEVENVWTTLADGwPKNLKIILH 1497
Cdd:pfam14228  656 ----------ES-----------------GW-----SERLLKSLYYVTWRHGDQFP-DEIEKLWRTIASK-PRNISPVLD 701

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 1498 FLIS--ICGVNSEPS---------LLPYVKKVIVYLGRDKTMQLLEELVSEL------QLTDPVSSGVTHMDnppyyrIT 1560
Cdd:pfam14228  702 FLISkgIEDCDSNASaeitgafatYFSVAKRVSLYLARICPQQTIDHLVYELaqrmleESVEPSRPSDGAFD------LE 775

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 1561 SSYKIPSVTSGTTSSSNTMVAPtdgNPDNKPikenieesyvhLDIYSGLNSHLNRQHHRLesryssssGGSYEEEKSDSM 1640
Cdd:pfam14228  776 SSAVLEFSQGPAPVQVAQLLDP---QPHMSP-----------LLVRSSLEGPLRNASGSL--------SWRTVTGRSMSG 833

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 1641 PLYSNWRLKVMEHNQGE-------PLPFPPAGGcwsPLV-------------------DYVPETSSPG------------ 1682
Cdd:pfam14228  834 PLNTMPEVVAVDTHTGRsgqlftgSGPLPNMSG---PLMgvrsstgslrshhvsrdsgDYFIDTPNSVeeiritpvvnas 910

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 1683 -----LPLH-----RCNIAVILLTDliIDHSVKVEWGSYLHLLLHAIFIGFDHCHPEVYEHCKRLLLHLLIVMGpksnir 1752
Cdd:pfam14228  911 elqsaLQGHqhwlsRADIALILLAE--IAYENDEDFRSHLPLLFHVTFVSMDSSEDIVLKHCQHLLVNLLYSLA------ 982

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 1753 tvasvllrnkefnePRVLTVKQVAHLDYnftagindfipdyqpspmtdsglsssstsssislgnnsaaishlhttilnev 1832
Cdd:pfam14228  983 --------------GRHLELYDVEHGDG---------------------------------------------------- 996

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 1833 disvEQDGKVKTLMEFITSRKRGPLWNHEDVSAKNPSIKSAEQLTTFLKHVVsvfkqsssEAIHLEHHLSEV----ALQT 1908
Cdd:pfam14228  997 ----EYKQQVVSLIKYVQSKRGSRMWENEDMTLTRTELPSAALLSALVLSMV--------DAIFFQGDLREKwgeeALKW 1064

                         1290      1300      1310      1320
                   ....*....|....*....|....*....|....*....|...
gi 1622939571 1909 ALSCSSRHYAGRSFQIFRALKQPLTATTLSDVLSRLVETVGDP 1951
Cdd:pfam14228 1065 AMECTSRHLACRSHQIYRALRPSVTSDTCVSLLRCLHRCLGNP 1107
 
Name Accession Description Interval E-value
Fry_C pfam19421
Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a ...
 2376-3099 0e+00

Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity. This domain binds to polo-like kinase 1 (Plk1) through the polo-box domain (PBD) of Plk1 in a manner dependent on the cyclin-dependent kinase 1-mediated Fry phosphorylation, promoting Plk1 activity during early mitosis. Fry also binds to Aurora A and may function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation.


Pssm-ID: 466072  Cd Length: 633  Bit Score: 1064.37  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 2376 VSKELPGKTLDFHFDISETPIIGNKYGDQHSAAGRNGKPKVIAVTRSTSSTSSGSNSNALVPVSWKRPQLSQRRTREKLM 2455
Cdd:pfam19421    1 SSKELPGKTLDFHFDISETPIIGRRYDELHGSAGRDGKPRVIAVTRSTSSTSSGSNSNVLVPVSWKRPQLSQKRTREKLV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 2456 NVLSLCGPESGLPKNPSVVFSSNEDLEVGDQQTSLISTtEDIIQEEEVaVEDNSSEQQFGVFKDFDFLDVELEDAEGESM 2535
Cdd:pfam19421   81 NVLSLCGQEVGLTKNPSVIFSSCGDLDLMDQQTSLVSS-EDGIREEEN-MDDTTSEQQFRVFRDFDFLDVELEDGEGESM 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 2536 DNFNWGVRRRSLDSIDKGDTPSLQEYQCSSSTPSLNLTNQEDTDESSEEEAaLTASQILSRTQMLNSDSATDEtmPDHPD 2615
Cdd:pfam19421  159 DNFNWGVRRRSLDSLDKGDTPSLEESQLSGSTPSLNLTNHEDSDESSEEES-LTASQILSHSQLLNSDSPTEE--PNHVD 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 2616 LLLQSQDSigSITTEEMLqiRDETPTLEASLdnansqlPEDTSSVlkeehvttfedegsyiiqeqqdslvcqgildleet 2695
Cdd:pfam19421  236 SLSQSQDS--SSADEESL--RAETPSLEVSL-------PEDASAR----------------------------------- 269

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 2696 empeplapesypesiceedvtlalkelderceeeeadfsglssqdeeeqdGFPEVQTSPLPSPFLSAIIAAFQPVAYDDE 2775
Cdd:pfam19421  270 --------------------------------------------------GFPEIQSSPPPSPFFSAILAAFQPVVCDDA 299

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 2776 EEAWRCHVNQMLSDTDGSSAVFTFHVFSRLFQTIQRKFGEITNEAVSFLGESLQRIGTKFKSSLEVMMICSECPTVFVDA 2855
Cdd:pfam19421  300 EEAWRCHVNQLVSDSDGSCAVYTFHVFSSLFQNIQRKFCSLTCDAVSYLGDSLRGIGSKFLSSSQMLTSCSECPTLFVDA 379

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 2856 ETLMSCGLLETLKFGVLELQEHLDTYNAKREATEQWLDDCKRTFGAKED--MYRINTDAQE---LELCRRLYKLHFQLLL 2930
Cdd:pfam19421  380 ETLMSCGLLEKLKFSVLELQEYLDTYNNKKEAAESWLDNCKATFPRGSGdgVITCQPADQEekqLELCQRLYKLHFQLLL 459

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 2931 LFQAYCKLINQVNTIKNEAEVINMSEELAQLESILKEAESVSEN-----EEIDISKAAQTTIETAIHSLIETLKNKEFIS 3005
Cdd:pfam19421  460 LFQSYCKLIGQVHAISSVPELINMSEELAQLESSLKEAEASVTSdelaqEESASSEPSFSSSEAAVQSILESLRNKEFST 539

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 3006 AVVQVKAFRSLWPSDIFGSCEDDPVQTLLHIYFHHQTLGQTGSFAVIGSNLDMSEANYKLMELNLEIRESLRMVQSYQLL 3085
Cdd:pfam19421  540 AIRQIKECRSLWPNDIFGSSSEDEVQTLLNIYFRHQTLGQTGTFALVGSNQDLSEICSKLMELNLEIRDMIRRAQGYRAL 619

                          730
                   ....*....|....
gi 1622939571 3086 AQPKPMGNMVSTGF 3099
Cdd:pfam19421  620 TAFLPDSSVSGSSL 633
MOR2-PAG1_N pfam14222
Cell morphogenesis N-terminal; This family is the conserved N-terminal region of proteins that ...
 209-741 0e+00

Cell morphogenesis N-terminal; This family is the conserved N-terminal region of proteins that are involved in cell morphogenesis.


Pssm-ID: 464107  Cd Length: 554  Bit Score: 630.38  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571  209 ERRDLAVDFIFCLVLVEVLKQIPVHPVPDPLVHEVLNLAFKHFKHKEGYSGTNTGNVHIIADLYAEVIGVLAQSKFQAVR 288
Cdd:pfam14222    1 ERKSLASIYILCRVLIEIVKQSPLDALTEELGDKLEEIVFGQLKTADPDQLSSSPNRSANWNLFAELLGVLSEIRFVSVS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571  289 KKFVTELKELRQKEQSPHVVQSVISLIMGMKFFRVKMYPVEDFEASFQFMQECAQYFLEVKDKDIKHALAGLFVEILIPV 368
Cdd:pfam14222   81 DRFIAELEKLPKGLSSKDLEAKIELLIRGMRYLRIKVYPEEAFEESADFMQSLAKFFLNAHGQRVKHAYAEVLVELLLPV 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571  369 AATVKNEVNVPCLKNFVEMLYQTTFELSSRKKHSLALYPLITCLLCVSQKQFFLNNWHIFLQNCLSHLKNKdpKMSRVAL 448
Cdd:pfam14222  161 AATATAEVNHPKWKEAVELLYPRAAKMASKPRHWNVAFPLVTTLLCVSPKEFFLSNWLSLIESLISKLKDK--TTRPVAL 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571  449 ESLYRLLWVYVIRIKcESNTVTQSRLMSIVSALFPKGSRSVVPRDTPLNIFVKIIQFIAQERLDFAMKEIIFDLLSVG-- 526
Cdd:pfam14222  239 QGLSRLLWVYLYRCT-ESLNTTTRKLESILKLLFPPGKKTWLPADPPLDPLVQIIRFIGFKHPDFCFENIIFPLLNADlf 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571  527 KSTKTFTINPERMNIGLRVFLVIADSLQQKDGEPPMPTTGVILPSGN--TLRVKKIFLNKTlTDEEAKVIGMSVYYPQVR 604
Cdd:pfam14222  318 NGLKLENLNPERMIIGIRAFLAILSDLEKGEQRPPFPQSFGTLPSPSssALRSKEENLSRP-VDTLALSEGIKDYYERFC 396

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571  605 KALDSILRHLDKEVGRPM-------------CMTSVQMSNKEPED-MITGERKPKIDLFRTCIAAIPRLIPDGMSRTDLI 670
Cdd:pfam14222  397 KILGKILILCDNTFGGQAvldekfssptpktPISETFNFSRRPDDnAYDGQRQPFYELLHTAVQAIPRCLPSSIPFNSLI 476

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571  671 ELLARLTIHMDEELRALAFNTLQALMLdfPDWREDVLSGFVYFIV---------REVTDIHPTLLDNAVKMLVQLINQWK 741
Cdd:pfam14222  477 ELLCRGTVHVDPNIAESAAQALKRIAR--PSHAQQVITGFARFIFnfddrystmSDGGMLGPGHIESLLKLYVELLEIWI 554
MOR2-PAG1_C pfam14225
Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that ...
 2093-2346 2.03e-75

Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that are involved in cell morphogenesis.


Pssm-ID: 464109  Cd Length: 252  Bit Score: 252.01  E-value: 2.03e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 2093 ATIFWIAASLLESDYEYEYLLALRLLNKLLIHLPLDKSESREKIENVQSKlKWTN-FPGLQQLFLKGFTSASTQEMTVHL 2171
Cdd:pfam14225    1 PQLFWTTVACLETIHEHEFLEALRLLEKLLDKLDLDDPDVVEKLLSSQPQ-KWEGkFEGLQPLLLKGLRSSVTLEPTLKL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 2172 LSKLISVSKHTLVDPSQlSGFPLNILCLLPHLIQHFDSP--TQFCKETASRIAKVCAEEKCPtlvNLAHMMSLYSTHTYs 2249
Cdd:pfam14225   80 LDRLTKLPDDRLVGPSD-SRLLFLVLANLPRFLHALDDPdiDPDCIETAENLAELAEEQGLP---SLARVLTSYAKGRF- 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 2250 RDCSNWINVVCRYLHDSFS-DTTFNLVTYLAELLEKGLSSMQQSLLQIIYSLLSHIDLSAAPAKQFNLEIIKIIGKYVQS 2328
Cdd:pfam14225  155 RTSDDFLKQVVSYLREAYFpDYEFQMLTFLLGLLTNGPPWVKVKTLQILKVLLPEIDMRRPEIAGHGADLISPLLRLLQT 234

                          250
                   ....*....|....*...
gi 1622939571 2329 PYWKEALNILKLVVSRSA 2346
Cdd:pfam14225  235 DLCMQALEVLDEIVTISG 252
MOR2-PAG1_mid pfam14228
Cell morphogenesis central region; This family is the conserved central region of proteins ...
 773-1951 6.09e-36

Cell morphogenesis central region; This family is the conserved central region of proteins that are involved in cell morphogenesis.


Pssm-ID: 433790 [Multi-domain]  Cd Length: 1113  Bit Score: 150.56  E-value: 6.09e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571  773 SNVFHV--VEGFALVILCSSRPATRKLAVSVLREIRALFALLEIPKGDDELAIDVMDRLSPSILESFIHLTGADQTTLLY 850
Cdd:pfam14228    1 TNEFRPsgLDAVGLIFLSSVDVQIRHTALELLRCVRALYNDLRDMSSKERSDVSWKNNKEPIFIIDVFEENGDDIVQQCY 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571  851 CPSSIDLQTLAEWNSSPISHQFDVISPShiwifahvtQGQDPWIISLSSFLKQENlpKHCSTAVSYAWMFAYTRLQLLSP 930
Cdd:pfam14228   81 WDSGRPYDMRRESDAIPPDLTLQSILES---------PDKGRWARCLSELVKYAA--ELCPSSVQEARLEVVQRLAQITP 149

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571  931 qVDINSpinakKVNTTTSSDSYIGLWRNYLILCCSaatsssstsagsvrCsPPETlasTPDSGYSidskiigipSPSSLF 1010
Cdd:pfam14228  150 -VELGG-----KAHQSQDADNKLDQWLLYSMFACS--------------C-PPDD---VEDTKSH---------SAKELY 196

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 1011 KHIVPMMRSESMEITESLVLGLGRTNPGAFRELIEELHPIIKEA---LERRPENMKRRRRRDILRVQLVRIFELLAD--- 1084
Cdd:pfam14228  197 HLIFPSLKSGSETHIHAATLALGHSHLEVCEPMFGELRSFLDEVateTESKPKWKSQKARREELRVHVANIYRMVAEnfw 276

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 1085 AGVISHSASGGLdnetHFLNntLLEyvDLTRQLLEAENEKDSDtLKDIRCHFSALVANIIQNVpVHQRRSIFPQQSlRHS 1164
Cdd:pfam14228  277 PGMLIRKPVFRL----HVLK--FIE--DTVRYITTSPLENFQD-LQPLRFALASVLRSLAPEF-VKSKSERFDPRT-RKR 345

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 1165 LFMLFSHWAGPFSIMFT---------PLDRYS------------------DRNMQINRHQYCALKAMSAVLCcGPVADNV 1217
Cdd:pfam14228  346 LFDLLASWCDDTGTVWSqdgvsdyrrEVERYKssqnsrskdsvdkisfdkEVNEQVEAIQWIAMNAMAALLY-GPCFDDN 424

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 1218 GLSSDGYLYKWLDNILD------------------------------SLDKKVHQLGCEAVTL-------LLELNPDqsn 1260
Cdd:pfam14228  425 ARKMSGRVIAWINGLFLepaprapfgyspadprtpsyskfagegvrgLGGKDRHRGGPLRVHLakvalknLLQTNLD--- 501

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 1261 LMYWAVDRCYTGSRRVAAGCFKAIANVFQNRDY-QFDTVMLLNLILFKAADSSRSIYEVAMQLLQILEPKmfRYAHKLEV 1339
Cdd:pfam14228  502 LFPACIDQCYSSDASIADGYFSVLAEVYMRQEIpRCDIQRLLSLILYKVVDPSRRIRDDALQMLETLSVR--EWAEDGEE 579

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 1340 QRTDGVLSQLSPLPHLYSVSYYQLSEELARAYPELTLAIFSEISQRIQTA--HPAGRQVmLHYLLPWMNNIELVDLKplp 1417
Cdd:pfam14228  580 GTGRYRAAVVGNLPDSYQQFQYKLSAKLAKDHPELSELLCEEIMQRQLDAvdIIAQHQV-LTCMAPWIENLNFLKLW--- 655

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 1418 tarrhdededDSlkdrelmvtsrrwlrgeGWgspqaTAMVLNNLMYMTAKYGDELAwSEVENVWTTLADGwPKNLKIILH 1497
Cdd:pfam14228  656 ----------ES-----------------GW-----SERLLKSLYYVTWRHGDQFP-DEIEKLWRTIASK-PRNISPVLD 701

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 1498 FLIS--ICGVNSEPS---------LLPYVKKVIVYLGRDKTMQLLEELVSEL------QLTDPVSSGVTHMDnppyyrIT 1560
Cdd:pfam14228  702 FLISkgIEDCDSNASaeitgafatYFSVAKRVSLYLARICPQQTIDHLVYELaqrmleESVEPSRPSDGAFD------LE 775

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 1561 SSYKIPSVTSGTTSSSNTMVAPtdgNPDNKPikenieesyvhLDIYSGLNSHLNRQHHRLesryssssGGSYEEEKSDSM 1640
Cdd:pfam14228  776 SSAVLEFSQGPAPVQVAQLLDP---QPHMSP-----------LLVRSSLEGPLRNASGSL--------SWRTVTGRSMSG 833

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 1641 PLYSNWRLKVMEHNQGE-------PLPFPPAGGcwsPLV-------------------DYVPETSSPG------------ 1682
Cdd:pfam14228  834 PLNTMPEVVAVDTHTGRsgqlftgSGPLPNMSG---PLMgvrsstgslrshhvsrdsgDYFIDTPNSVeeiritpvvnas 910

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 1683 -----LPLH-----RCNIAVILLTDliIDHSVKVEWGSYLHLLLHAIFIGFDHCHPEVYEHCKRLLLHLLIVMGpksnir 1752
Cdd:pfam14228  911 elqsaLQGHqhwlsRADIALILLAE--IAYENDEDFRSHLPLLFHVTFVSMDSSEDIVLKHCQHLLVNLLYSLA------ 982

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 1753 tvasvllrnkefnePRVLTVKQVAHLDYnftagindfipdyqpspmtdsglsssstsssislgnnsaaishlhttilnev 1832
Cdd:pfam14228  983 --------------GRHLELYDVEHGDG---------------------------------------------------- 996

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622939571 1833 disvEQDGKVKTLMEFITSRKRGPLWNHEDVSAKNPSIKSAEQLTTFLKHVVsvfkqsssEAIHLEHHLSEV----ALQT 1908
Cdd:pfam14228  997 ----EYKQQVVSLIKYVQSKRGSRMWENEDMTLTRTELPSAALLSALVLSMV--------DAIFFQGDLREKwgeeALKW 1064

                         1290      1300      1310      1320
                   ....*....|....*....|....*....|....*....|...
gi 1622939571 1909 ALSCSSRHYAGRSFQIFRALKQPLTATTLSDVLSRLVETVGDP 1951
Cdd:pfam14228 1065 AMECTSRHLACRSHQIYRALRPSVTSDTCVSLLRCLHRCLGNP 1107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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