|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC18B1 |
cd17385 |
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ... |
1-384 |
0e+00 |
|
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340943 [Multi-domain] Cd Length: 390 Bit Score: 535.26 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 1 MNLGSMMCYSILGPFFPKEAEKKGTSNTIIGMIFGCFALFELLACLVFGNYLVHIGAKFMFVAGMFVSGGVTILFGVLDR 80
Cdd:cd17385 7 ANFSSMICYSILAPFFPREAEKKGVSDTIIGLVFGCFALVIFLTSPIFGKYLVKIGAKFMFVAGMFVSGGCTILFGFLDR 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 81 VPDGPVFIAMCFLVRVMDAVSFAAAVTASSSILAKAFPNNVATVLGSLETFSGLGLILGPPVGGFLYQSFGYEVPFIVLG 160
Cdd:cd17385 87 VPDGTVFIALCFLVRIVEAVGFAAFITASFAIIAKEFPNNIATVLGTLETFSGLGLMLGPPLGGFLYQAGGYELPFLVLG 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 161 CIILLMVPLNMYILPNYESDPGEH--SFWKLIALPKVGLIAFVINSLSSCFGFLDPTLSLFvLEKFNLPAGYVGLVFLGL 238
Cdd:cd17385 167 CLLLLTVPLNMFILPRYDDDPSPKsgSMLKLLKIPSVLLLCLSIVSGSVSLGFLDPTLSPH-LRQFKLSPGQVGLMFLIL 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 239 ALSYAISSPLFGLLSDKMpPLRKWLLVFGNLITAGCYILLGPVPVLHIKSQLWLLVLILVVNGISAGMSIIPTFPEILSC 318
Cdd:cd17385 246 AGSYAISAPLWGWLSDKK-KIPKWLMVIGSIITGVGFLLLGPAPLLPIKSELWMVIIGLVLLGLSLGAALVPTFPELLNC 324
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622928889 319 AHENGFEEGLSTLGLVSGLFSAMWSIGAFLGPTLGGFLYEKIGFEWAAAIQGLWALISGLAMGLFY 384
Cdd:cd17385 325 AREYGFPDNLSTYGLVSGLFNAAFSLGAFIGPTLGGFLLERLGFEWAATIQAGLAFVVGILMSIYY 390
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
5-384 |
1.61e-54 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 185.09 E-value: 1.61e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 5 SMMCYSILGPFFPKEAEKKGTSNTIIGMIFGCFALFELLACLVFGNYLVHIGAKFMFVAGMFVSGGVTILFGVLDrvpdg 84
Cdd:cd17325 8 DMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFAT----- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 85 pvFIAMCFLVRVMDAVSFAAAVTASSSILAKAFP-NNVATVLGSLETFSGLGLILGPPVGGFLYQSFGYEVPFIVLGCII 163
Cdd:cd17325 83 --SYWQLLLARFLQGLASAAVWPAAMALIADIAPpEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 164 LLMVPLNMYILPNYE---------SDPGEHSFWKLIALPKVGLIAFVINSLSSCFGFLDPTLSLFVLEKFNLPAGYVGLV 234
Cdd:cd17325 161 LLALVLALLLLPEPRpppnkravsAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 235 FLGLALSYAISSPLFGLLSDKMPplRKWLLVFGNLITAGCYILLGPVPVLHIksqlwlLVLILVVNGISAGMSIIPTFPE 314
Cdd:cd17325 241 FGAQGLASALSQPPAGKLSDRIG--RKPLILIGLLLSAVALLLLPLATSFWL------LLLLLALLGLGLGLVFPATLAL 312
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 315 ILSCAHENGfeeglstLGLVSGLFSAMWSIGAFLGPTLGGFLYEKIGFEWAAAIQGLWALISGLAMGLFY 384
Cdd:cd17325 313 LADIVPPEG-------RGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
24-383 |
1.66e-23 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 100.71 E-value: 1.66e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 24 GTSNTIIGMIFGCFALFELLACLVFGNYLVHIGAKFMFVAGMFVSGGVTILFGVldrVPDGPVFIAMCFLVrvmdAVSFA 103
Cdd:COG2271 41 GLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGF---ATSFWQLLLLRFLL----GLGEA 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 104 AAVTASSSILAKAFPNNV-ATVLGSLETFSGLGLILGPPVGGFLYQSFGYEVPFIVLGCIILLMVPLNMYILpnyesdpg 182
Cdd:COG2271 114 GFFPAALKLIAEWFPPKErGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALLRFWLL-------- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 183 ehsfwklialpkvGLIAFVINSLSSCFGFLdptLSLFVLEKFNLPAGYVGLVFLGLALSYAISSPLFGLLSDKMPPLRKW 262
Cdd:COG2271 186 -------------ALAYFLVYFALYGFLTW---LPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 263 LLVFGNLITAGCYILLGPVPVLHIksqlWLLVLILVVNGISAGMSIIPTFPEILScahengfeeGLSTLGLVSGLFSAMW 342
Cdd:COG2271 250 VLAIGLLLAALALLLLALLPSPAL----AIALLFLAGFGLGGAFGLLWALAAELF---------PKKARGTASGLVNTFG 316
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1622928889 343 SIGAFLGPTLGGFLYEKIGFEWAAAIQGLWALISGLAMGLF 383
Cdd:COG2271 317 FLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLL 357
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
1-346 |
2.25e-22 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 97.35 E-value: 2.25e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 1 MNLGSMMCYSILGPFFPKEAEKKGTSNTIIGMIFGCFALFELLACLVFGNYLVHIGAKFMFVAGMFVSGGVTILFGVldr 80
Cdd:COG2814 18 GAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCAL--- 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 81 VPDGPVFIAMcflvRVMDAVSFAAAVTASSSILAKAFP-NNVATVLGSLETFSGLGLILGPPVGGFLYQSFGYEVPFIVL 159
Cdd:COG2814 95 APSLWLLLAA----RFLQGLGAGALFPAALALIADLVPpERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVN 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 160 GCIILLMVPLNMYILPNY---ESDPGEHSFWKLIALPKVGLIAFVINSLSSCFGFLDPTLSLFVLEKFNLPAGYVGLVFL 236
Cdd:COG2814 171 AVLALLALLLLLRLLPESrpaARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLA 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 237 GLALSYAISSPLFGLLSDKMPplRKWLLVFGNLITAGCYILLGPVPVLhiksqlWLLVLILVVNGISAGMSIIPTFPEIL 316
Cdd:COG2814 251 LFGLGGVLGALLAGRLADRFG--RRRLLLIGLLLLALGLLLLALAGSL------WLLLLALFLLGFGFGLLFPLLQALVA 322
|
330 340 350
....*....|....*....|....*....|
gi 1622928889 317 SCAHENGfeeglstLGLVSGLFSAMWSIGA 346
Cdd:COG2814 323 ELAPPEA-------RGRASGLYNSAFFLGG 345
|
|
| MFS_SLC18A1_2_VAT1_2 |
cd17384 |
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ... |
27-364 |
7.50e-19 |
|
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340942 [Multi-domain] Cd Length: 373 Bit Score: 87.24 E-value: 7.50e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 27 NTIIGMIFGCFALFELLACLVFGNYLVHIGAKFMFVAG---MFVSggvTILFGVldrvpdGPVFIAMcFLVRVMDAVSFA 103
Cdd:cd17384 30 NVRVGLLFASKALVQLITNPIVGPLTNRIGYSLPMFVGfviMFIS---TLLFAF------GESYGVL-FLARALQGVGSA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 104 AAVTASSSILAKAFPNN------VATVLGSLetfsGLGLILGPPVGGFLYQSFGYEVPFIVLGCIILLMVPLNMYIL-PN 176
Cdd:cd17384 100 CSSVAGMGMLASLYPDDkergkaMGIALGGL----ALGVLVGPPFGGVMYEFVGKSAPFLILAFLALLDGALQLFILqPS 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 177 YESDPGEH--SFWKLIALPKVGLIAFVINSLSSCFGFLDPTLSLFVLEKFNLPAGYVGLVFLGLALSYAISSPLFGLLSD 254
Cdd:cd17384 176 VKSEESEEgtPWKTLLKDPYILIAAGAICFSNSGIAILEPCLPIWMMETMCPPKWQLGTAFLPDSIGYLIGTNLFGPLAH 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 255 KMpplRKWLLVFGNLITAGCYILLGPvpvlhIKSQLWLLVLILVVNGISAGM---SIIPTFPEILSCAHEngfeeglSTL 331
Cdd:cd17384 256 KI---GRWLCSLLGMLLVGISLILIP-----LAKNIYGLIIPHFGLGLGIGMvdsSMMPLLAYLVDLRHS-------SVY 320
|
330 340 350
....*....|....*....|....*....|...
gi 1622928889 332 GLVSGLFSAMWSIGAFLGPTLGGFLYEKIGFEW 364
Cdd:cd17384 321 GSVYAIADVAFCLAFALGPSLGGAIVKSIGFPW 353
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
5-384 |
1.17e-18 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 86.86 E-value: 1.17e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 5 SMMCYSILGPFFPKEAEKKGTSNTIIGMIFGCFALFELLACLVFGNYLVHIGAKFMFVAGMFVSGGVTILFGVldrVPDG 84
Cdd:COG2223 17 AFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLAL---AVSY 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 85 PVFIAMCFLVRVMDAVSFAAAVtassSILAKAFP-NNVATVLGSLETFSGLGLILGPPVGGFLYQSFGYEVPFIVLGCII 163
Cdd:COG2223 94 WLLLLLGLLLGIGGGGSFAVGI----ALVSKWFPpDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 164 LLMVPLNMYILPNYESDPGE------HSFWKLIALPKVGLIAFVINSLSSCFGFLDPTLSLFVLEKFNLPAGYVGLVFLG 237
Cdd:COG2223 170 LVVAVLAWLFLRDPPAGAAAaakaslRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAAL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 238 LALSYAISSPLFGLLSDKMPPlRKWLLVFGNLITAGCYILLGPVPVLhiksqlWLLVLILVVNGISAGMSIIPTFPEIls 317
Cdd:COG2223 250 FALLGALGRPLGGWLSDRIGG-RRVLLIVFALMALGLLLLALALGSL------WLFLVLFLLLGLALGGGNGAVFALV-- 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622928889 318 cahenGFEEGLSTLGLVSGLFSAMWSIGAFLGPTLGGFLYEKIG-FEWAAAIQGLWALISGLAMGLFY 384
Cdd:COG2223 321 -----PDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVLTLLLY 383
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
1-350 |
1.18e-17 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 83.62 E-value: 1.18e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 1 MNLGSMMCYSILGPFFPKE-AEKKGTSNTIIGMIFGCFALFELLACLVFGNYLVHIGAKFMFVAGMFVSGGVTILFGVLD 79
Cdd:pfam07690 4 AAFLAALGRSLLGPALPLLlAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 80 RVPdgpvfiaMCFLVRVMDAVSFAAAVTASSSILAKAFP-NNVATVLGSLETFSGLGLILGPPVGGFLYQSFGYEVPFIV 158
Cdd:pfam07690 84 SLW-------LLLVLRVLQGLGAGALFPAALALIADWFPpEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 159 LGCIILLMVPLNMYILPNYESDP---------GEHSFWKLIALPKVGLIAFVINSLSSCFGFLDPTLSLFVlEKFNLPAG 229
Cdd:pfam07690 157 LAILSLLAAVLLLLPRPPPESKRpkpaeearlSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQ-EVLGLSAL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 230 YVGLVFLGLALSYAISSPLFGLLSDKMPPLRKWLLVFGNLITAGCYILLGPVPVLHIKSQLWLlvlilvvngISAGMSII 309
Cdd:pfam07690 236 LAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLAL---------LLLGFGFG 306
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1622928889 310 PTFPEILSCAHENGFEEglsTLGLVSGLFSAMWSIGAFLGP 350
Cdd:pfam07690 307 LVFPALNALVSDLAPKE---ERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
2-385 |
1.31e-17 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 83.80 E-value: 1.31e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 2 NLGSMMCYSILGPFFPKEAEKKGTSNTIIGMIFGCFALFELLACLVFGNYLVHIGAKFMFVAGMFVSGGVTILFGVLDRv 81
Cdd:cd17489 5 NFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATS- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 82 pdgpvfIAMCFLVRVMDAVSFAAAVTASSSILAKAFPN-NVATVLGSLETFSGLGLILGPPVGGFLYQSFGYEVPFIVLG 160
Cdd:cd17489 84 ------VALLLVLRLIHGIGWGAFTTAAATLVADIIPPsRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 161 CIILLMVPLNMYILPNYESDPGEH----SFWKLIALPKVGLIAFVINSLSSCFGFLDPTLSLFVLEkfnLPAGYVGLVFL 236
Cdd:cd17489 158 VLALLALLLVFLVKDPPPVAAEEAeagtRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAE---RGISNAGLFFT 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 237 GLALSYAISSPLFGLLSDKMPPlrKWLLVFGNLITAGCYILLGPVPVLHiksqlwLLVLILVVNGISAGMSIIPTFPEIL 316
Cdd:cd17489 235 VYAIALLLSRPFSGKLSDRKGP--KTVIIPGLLLLALGLLLLSFAGSPW------MLLLAAVLYGLGFGLLFPALQALAV 306
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622928889 317 SCAHENGFeeglstlGLVSGLFSAMWSIGAFLGPTLGGFLYEKIGFEWAAAIQGLWALIsGLAMGLFYL 385
Cdd:cd17489 307 DLVPPHRR-------GAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLL-ALVLYIFLL 367
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
9-383 |
2.93e-17 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 82.61 E-value: 2.93e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 9 YSILGPFFPKEAEKKGTSNTIIGMIFGCFALFELLACLVFGNYLVHIGAKFMFVAGMFVSGGVTILFGVLDRVpdgPVFI 88
Cdd:cd17477 12 SGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSP---WVWF 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 89 AMCFLVRVMDAVSFaaaVTASSSILAKAFPNNVATVLGSLETFSGLGLILGPPVGGFLYQSfGYEVPFIVLGCIILLMVP 168
Cdd:cd17477 89 LLRFVMGIGLAGLF---VVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTA-GALPFLIAAVLLLLALVP 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 169 LNMYILPNYESDPGEH-SFWKLIALPKVGLIAFVINSL--SSCFGFldptLSLFVLEKfNLPAGYVGLVFLGLALSYAIS 245
Cdd:cd17477 165 LLLTRRAAPEIEEAESiSLRRLLRIAPLALLGAFVAGFleGAFYSL----LPLYGLRL-GLSVAQAALLLAAFVLGGLLL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 246 SPLFGLLSDKMPplRKWLLVFGNLITAGCYILLGPVPvlhiksqlwLLVLILVVNGISAGMSIIPTFPeiLSCAHENGFE 325
Cdd:cd17477 240 QWPLGWLADRFD--RRRVLLGCALLGALAALLLPLVP---------GLPLALLVLLFLWGGAAGPLYT--LALALAGDRL 306
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1622928889 326 EGlSTLGLVSGLFSAMWSIGAFLGPTLGGFLYEKIGfewaaaIQGLWALISGLAMGLF 383
Cdd:cd17477 307 PG-DELVAANAALLLLYGLGSVIGPLLAGALMDAFG------PHGLFLFLAAVALLFL 357
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
5-376 |
3.32e-15 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 76.08 E-value: 3.32e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 5 SMMCYSILGPFFP---KEAEKKGTSNTIIGMIFGCFALFELLACLVFGNYLVHIGAKFMFVAGMFVSGGVTILFGVLdrv 81
Cdd:cd17330 8 DALGFGIVFPVLPfyvREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLS--- 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 82 pdgpVFIAMCFLVRVMDAVSFAAAVTASSSILAKAFPNNVATVLGSLETFSGLGLILGPPVGGFLYQSFGYEVPFIVlGC 161
Cdd:cd17330 85 ----RNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLV-AA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 162 IILLMVPLNMYILpnyesdpgehsfwkliaLPKVGLIAFVINSLSSCFGFLDPTLSLFVLEKFNLPAGYVGLVFLGLALS 241
Cdd:cd17330 160 ALALLNLVLVLFF-----------------LPPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIA 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 242 YAISSPLFGLLSDKMPPLRKwLLVFGNLITAGCYILLGPVPVLHIksqlwllvLILVVNGISAGMSIipTFPEILSCAHE 321
Cdd:cd17330 223 GILAQLLLIPRLAKRLGERK-LLRLGLLLAIIGLLLLPFASSVPL--------LVLAAAILAFGTGI--VFPALSALLSK 291
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1622928889 322 NGfeeGLSTLGLVSGLFSAMWSIGAFLGPTLGGFLYEKIGFEWAAAIQGLWALIS 376
Cdd:cd17330 292 SV---PSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIA 343
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
10-378 |
2.01e-13 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 71.06 E-value: 2.01e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 10 SILGPFFPKEAEKKGTSNTIIGMIFGCFALFELLACLVFGNYLVHIGAKFMFVAGMFVSGGVTILFGVLDRvpdgpvfIA 89
Cdd:cd17474 16 SIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDS-------FA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 90 MCFLVRVMDAVSFAAAVTASSSILAKAFP-NNVATVLGSLETFSGLGLILGPPVGGFLyQSFGYEVPFIVLGCIILLMVP 168
Cdd:cd17474 89 LLLAGRALQGIGAAGLGPLALTLIGDLFEgGERAKAMGLYEAALGLGIAVGPLLGGLL-AAISWRYPFFLLAALIPVAFL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 169 LNMYILPNYESDPGEHSFWKLIALPKV----GLIAFVINSLSSCFGF--LDPTLSLFVLEKFNLPAGYVGLVFLGLALSY 242
Cdd:cd17474 168 AILFLLPEPKEKAKSSSATKLRDLKKAlrgrGLLTFLVSAFLYFFLYfaFLTYLPFLLELLYGISPIIIGLLFAGWSVLL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 243 AISSPLFGLLSdKMPPLRKWLLVFGNLITAGCYILLGPVPvlhiksQLWLLVLILVVNGISAGMSIiPTFPEILScaheN 322
Cdd:cd17474 248 ALGSLFVGRLL-KKRFGARRILVIGLLLYALSLLLLGFVP------SLALLLIAIVLFGLGLGLNL-PLLTTLVT----E 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1622928889 323 GFEEGLstLGLVSGLFSAMWSIGAFLGPTLGGFLYEKIGFEWAAAIQGLWALISGL 378
Cdd:cd17474 316 LAPEEE--RGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAV 369
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
7-395 |
5.32e-12 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 66.80 E-value: 5.32e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 7 MCYSILGPFFPKEAEKKGTSNTIIGMIFGCFALFELLACLVFGNYLVHIGAKFMFVAGMFVSGGVTILFGVldrVPDGPV 86
Cdd:COG0738 22 FATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFAL---APSYPL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 87 FIAMCFLVrvmdAVSFAAAVTASSSILAKAFPNNVATVLGSLETFSGLGLILGPPVGGFLYQ---SFGYEVPFIVLGCII 163
Cdd:COG0738 99 LLLALFLL----GLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILlglSLSWHLPYLILAVLL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 164 LLM------VPLNMYILPNYESDPGEHSFWKLIALPKVGLIAFVINSLSSCFGFLDPTLSLFVLEKFNLPAGYVGLVFLG 237
Cdd:COG0738 175 LLLallflrSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSL 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 238 LALSYAISSPLFGLLSDKMPPlrKWLLVFGNLITAGCYILLGPVPVLHIksqlwllvLILVVNGISAGMSIIptFPEILS 317
Cdd:COG0738 255 FWGGMTIGRFLGGFLLKRFGP--VRLLRLSALLAAVGLLLALLAPGPWL--------ALIGLALVGLGLSLM--FPTIFS 322
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622928889 318 CAHENGFEEGLSTLGLVSglfsAMWSIGAFLGPTLGGFLYEKIGFEWAaaiqgLWALISGLAMGLFYLLEYSRRRRSK 395
Cdd:COG0738 323 LALDGLGKRTAAAVSAVL----IMGIVGGAIGPPLIGFLADAFGLRAA-----FLVPLVCYLLILLLALALKRKRRKK 391
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
24-376 |
2.37e-11 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 64.88 E-value: 2.37e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 24 GTSNTIIGMIFGCFALFELLACLVFGNYLVHIGAKFMFVAGMFVSGGVTILFGVLdrvpdgPVFIAMcFLVRVMDAVSFA 103
Cdd:cd17324 30 GVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALA------PSFALL-LLARALAGLAHG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 104 AAVTASSSILAKAFP-NNVATVLGSLETFSGLGLILGPPVGGFLYQSFGYEVPFIVLGCIILLMVPLNMYILPNYESDPG 182
Cdd:cd17324 103 GFWAIAAAYAADLVPpEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKP 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 183 EH-----SFWKLIALPKVGLIAFVINSLSSCFGFLDPTLSLFVLEKFNLPAGYVGLVFLGLALSYAISSPLFGLLSDKMP 257
Cdd:cd17324 183 GSlgllsSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGG 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 258 PLRkwlLVFGNLITAGCYILLgpvPVLHIKSQLWLLVLILVVNGISAGMSIIPTFpeILSCAHENgfeeglstLGLVSGL 337
Cdd:cd17324 263 RRA---LLIALLLLAAALLLL---TLLGPSPLLLLVGLVLWGLGFFAAHSALQTR--VLRLAPEA--------RGLASSL 326
|
330 340 350
....*....|....*....|....*....|....*....
gi 1622928889 338 FSAMWSIGAFLGPTLGGFLYEKIGFEWAAAIQGLWALIS 376
Cdd:cd17324 327 YLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLA 365
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
2-383 |
1.13e-10 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 63.00 E-value: 1.13e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 2 NLGSMMCYSILGPFFPK-EAEKKGTSNTIIGMIFGCFALFELLACLVFGNYLVHIGAKF-----MFVAGMFVSGGVTILF 75
Cdd:COG2211 19 DLGLNLAFGLLSAYLLYfYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWgrrrpWILIGAIPLALSFVLL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 76 GVLDRVPDGPVFIaMCFLVRVMDAVSFAAAVTASSSILAKAFPNNV--ATVLGSLETFSGLGLILGPPVGGFLYQSF--- 150
Cdd:COG2211 99 FTAPDLSPTGKLI-YALVTYLLLGLAYTLVNIPYSALGAELTPDYEerTRLSSWRFAFAGLGGLLASVLPPPLVAAFggd 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 151 ---GYEVPFIVLGCIILLMVPLNMYILPNYESDPGEHS----FWKLIALPKVGLIAFVINSLSSCFGFLDPTLSLFVLEK 223
Cdd:COG2211 178 aalGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVslkeSLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKY 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 224 -FNLPAGYVGLVFLGLALSYAISSPLFGLLSDKMPplRKWLLVFGNLITAGCYILLGPVPVlhikSQLWLLVLILVVNGI 302
Cdd:COG2211 258 vLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFG--KKKAFIIGLLLAALGLLLLFFLGP----GNLWLLLVLAALAGI 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 303 SAGMSIIPTFPEILSCAHENGFEEGLSTLGLVSGLFSAMWSIGAFLGPTLGGFLYEKIGFEWAA-----AIQGLWALISG 377
Cdd:COG2211 332 GLGAILVLPWAMLADVVDYDEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYVAGAaqspsALTGIRLLFFL 411
|
....*.
gi 1622928889 378 LAMGLF 383
Cdd:COG2211 412 LPAVLL 417
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
1-379 |
2.18e-10 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 61.67 E-value: 2.18e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 1 MNLGSMMCYSILGPFFPKEAEKKGTSNTIIGMIFGCFALFELLACLVFGNYLVHIGAKFMFVAGMFVSGGVTILFGVldr 80
Cdd:cd06174 4 GFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF--- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 81 vpdgPVFIAMCFLVRVMDAVSFAAAVTASSSILAKAFP-NNVATVLGSLETFSGLGLILGPPVGGFLYQ--SFGYEVPFI 157
Cdd:cd06174 81 ----APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPeRERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVFL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 158 VLGCIILLMVPLNMYILPNYESDPGE-----------HSFWKLIALPKVGLIAFVINSLSSCFGFLDPTLSLFVLEKFNL 226
Cdd:cd06174 157 IAAALALLAAILLLLVVPDPPESARAkneeassksvlKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 227 PAGYVGLVFLGLALSYAISSPLFGLLSDKMPPLRKWLLVFGNLITAGC-YILLGPVPVLHIKSQLWLLVLILVVNGISAG 305
Cdd:cd06174 237 SVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLaLLLLAPSLLLLLLLLLLLGFGLGGLLPLSFA 316
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622928889 306 MSIIPTFPEIlscahengfeeglstLGLVSGLFSAMWSIGAFLGPTLGGFLY-EKIGFEWAAAIQGLWALISGLA 379
Cdd:cd06174 317 LIAELFPPEI---------------RGTAFGLLNTFGFLGGAIGPLLAGFLLaATFGLTGAFLVLAVLLLLAAIL 376
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
55-357 |
5.35e-10 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 60.65 E-value: 5.35e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 55 IGAKFMFVAGMFVSGGVTILFGVldrVPDGPVFIAMcflvRVMDAVSFAAAVTASSSILAKAFP-NNVATVLGSLETFSG 133
Cdd:cd17321 58 FGRKRVFLIGLALFGLASLLCAL---APSLAFLIAA----RALQGIGAAAIMPASLALIAATFPgERRGRALGLWGAVVG 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 134 LGLILGPPVGGFLYQSFGYEVPFIVLGCIILLMvplnmyilpnyesdpgehsfwkLIALPKVGLIAFVINSLSSCFGFLD 213
Cdd:cd17321 131 IGAALGPLLGGLLLELFGWRWIFLINVPIGLVA----------------------LLLARTFSGAVLAAFLLGAALGGLL 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 214 PTLSLFVLEKFNLPAGYVGLVFLGLALSYAISSPLFGLLSDKMPPlrKWLLVFGNLITAGCYILLGPVPVLHIKSQLWLL 293
Cdd:cd17321 189 FLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGP--RLVLVAGLLLTAVGLLLLALLGADSSVWLLLPG 266
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622928889 294 VLILvvnGISAGMSIIPTFPEILSCAHENgfeeglsTLGLVSGLFSAMWSIGAFLGPTLGGFLY 357
Cdd:cd17321 267 LVLL---GLGLGLFATPLTNAALSSVPKE-------KAGAASGILNTARQLGGALGVALLGALL 320
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
1-380 |
2.49e-09 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 58.32 E-value: 2.49e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 1 MNLGSMMCYSILGPFFpkeaEKKGTSNTIIGMIFGcfaLFELLACL--VFGNYLVHI--GAKFMFVAGMFVSGGVTILFG 76
Cdd:cd17370 11 ADISYEMARSILPLFL----VVLGASAAAVGLIEG---LAEALGSLlrLFSGYLSDRtgKRKPLVILGYGLSALAKPLLA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 77 VLDRVPDgpVFIAMcFLVRVMDAVSFAA-----AVTASSSILAKAFpnnvatvlGSLETFSGLGLILGPPVGGFL--YQS 149
Cdd:cd17370 84 LAGSWQL--VLLLR-ILERLGKGIRTPPrdallADATPPSGRGKAF--------GLHRALDTLGAVLGPLLAALLlyLLG 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 150 FGYEVPFIVLGCIILLMVPLNMYILPNYE--SDPGEHSFW-KLIALPKVGLIAFVINSLSScFGFLDPTLSLFVLEKFNL 226
Cdd:cd17370 153 GNYRTIFLLAAIPALLALLILLFVVKEYPrpPKLRKKSKKtSLKKLPKAFWLYLLAVALFA-LGNFSFAFLILRAQELGL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 227 PAGYVGLVFLGLALSYAISSPLFGLLSDKMPplRKWLLVFGNLITAGCYILLGpvpvlhIKSQLWLLVLILVVNGISAGM 306
Cdd:cd17370 232 SAALIPLLYALFNLVYALAAYPAGRLSDRIG--RKKLLILGYLSLALAYLGFA------LGSSLWLLLLGFILWGLYMGA 303
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622928889 307 --SIIPTFPEILSCAHENGFeeglstlglVSGLFSAMWSIGAFLGPTLGGFLYEKIGFEWAAAIQGLWALISGLAM 380
Cdd:cd17370 304 qeSIERAAVADLVPAELRGT---------AYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLL 370
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
10-379 |
4.52e-09 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 57.58 E-value: 4.52e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 10 SILGPFFPKEAekkGTSNTIIGMIFGCFALFELLACLVFGNYLVHIGAKFMFVAGMFVSGGVTILFGVldrVPDGPVFIA 89
Cdd:cd17319 23 SVAAPTIMKDL---GLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGF---ATSLTSLYV 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 90 MCFLVRVMDAVSFAAAVTAsssiLAKAFPNNV-ATVLGSLETFSGLGLILGPPVGGFLYQSFGYEVPFIVLGCIILLMVP 168
Cdd:cd17319 97 LRFLLGVAEAGFFPGAIKA----LAEWFPARErGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAV 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 169 LnmyilpnyesdpgehsfWkLIALPKVGLIAFVINSLSSCFGFLDPTLSLFVLEKFNLPAGYVGLVFLGLALSYAISSPL 248
Cdd:cd17319 173 L-----------------W-WFYLRQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMIL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 249 FGLLSDKMPPL-RKWLLVFGNLITAGCYILLGPVPVLHIksqlWLLVLILVVNGISAGMSIIPTFPEILScahengfeeG 327
Cdd:cd17319 235 GGRLSDRLLRGaRRLVIIIGLLLAAVGLLLAYLTTSPVV----AVILLSLAGFGIGAASPVFWSLPADLL---------P 301
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1622928889 328 LSTLGLVSGLFSAMWSIGAFLGPTLGGFLYEKIG-FEWAAAIQGLWALISGLA 379
Cdd:cd17319 302 GEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGsYTAAFLFLAAVALLAALL 354
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
14-384 |
1.60e-08 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 56.08 E-value: 1.60e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 14 PFFPKEAEKKGTSNTIIGMIFGCFALFELLACLVFGNYLVHIGAKFMFV-AGMFVSGGVTILFGVLDRVpdgpvfiAMCF 92
Cdd:cd17490 17 PFLSPYAESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFIiIGLLFTVLASLIMILFPSP-------WGLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 93 LVRVMDAVSFAAAVTASSSILAKAFPNNVATVLGSLETFSGLGLILGPPVGGFLYQSFGYEVPFIVLGCI----ILLMVP 168
Cdd:cd17490 90 IARFLSGIAAATWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAgvlgFILSLF 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 169 LNMYILPNYESDPGEHSFWKLIALPKV------GLIAFVINsLSSCFGFLDPTLSLFVLEKFNLpaGYVGLVFLglaLSY 242
Cdd:cd17490 170 IKEERREKKPVLTELKELLSVLKDKKLlffsllAILQQMIT-FSTTFGFTPLIAKQLGASSFQL--GLLSIIYL---LPN 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 243 AISSPLFGLLSDKMPPLRKWLLvFGNLITAGCYILlgpVPVLhikSQLWLLVLILVVNGISAGMsiipTFPEILSCAHEN 322
Cdd:cd17490 244 ALASLLSGTLFYKKLGERNTII-IGFLLLGAYCFL---IPFA---PNLTLLYLLQALNGFGTGI----LFPLLMSLSIEG 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622928889 323 GFEEGLSTlglVSGLFSAMWSIGAFLGPTLGGFLYEKIGFEWAAAIQGLWALISGLAMGLFY 384
Cdd:cd17490 313 VPAEQRST---AMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAILSLAYY 371
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
7-386 |
1.82e-08 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 56.07 E-value: 1.82e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 7 MCYSILGPFFPKEAEKKGTSNTIIGMIFGCFALFELLACLVFGNYLVHIGAKFMFVAGMFVSGGVTILFGVLDRVPdgpv 86
Cdd:cd17331 14 TCYWLQQPVLPYLTKKLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVP---- 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 87 fiaMCFLVRV----MDAVSFAAAVTASSSIlakafPNNVATVLGSLETFSGLGLILGPPVGGFLYQSFGYEVPFIVLGCI 162
Cdd:cd17331 90 ---MLFLSRLpsvfMHAMQAAQMVVTDLTD-----PGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 163 ILLMVPLNMYILPNYE------------SDPGEHSFWKLIAL---PKVGLIAFVINSLSSCFGFLDPTLSLFVLEKFNLP 227
Cdd:cd17331 162 SLLSIVLVILLIPSNTkskrekeakesaSPPSVFNLKEILRLlrlPGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLT 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 228 AGYVGLVFLGLALSYAIS-----SPLFGLLSDKMpplrkwLLVFGNLITAGCYILLGPVPVLhiksqlwlLVLILVVNGI 302
Cdd:cd17331 242 PEENGYLMSYAGVLGMVVqgllvGPLTKRFGERS------LLKLSVALLAIGYLLLAFVTTV--------WQLLVLLLPL 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 303 SAGMSIIPTfpeILSCAHENGFEEglSTLGLVSGLFSAMWSIGAFLGPTLGGFLYEKIGFewaAAIQGLWALISGLAmgL 382
Cdd:cd17331 308 VIGGSVLYT---VITSLLTKAVPP--EDTGTALGLSHALFSLVRTVSPTIGGALLQAYGF---PSFGLLGAAINGLL--T 377
|
....
gi 1622928889 383 FYLL 386
Cdd:cd17331 378 VYLL 381
|
|
| MFS_SLC18A3_VAChT |
cd17383 |
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator ... |
7-236 |
1.96e-08 |
|
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator Superfamily; Vesicular acetylcholine transporter (VAChT) is also called solute carrier family 18 member 3 (SLC18A3) in vertebrates and uncoordinated protein 17 (unc-17) in Caenorhabditis elegans. It is a glycoprotein involved in acetylcholine transport into synaptic vesicles and is responsible for the accumulation of acetylcholine into pre-synaptic vesicules of cholinergic neurons. Variants in SLC18A3 are associated with congenital myasthenic syndrome in humans. VAChT belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340941 [Multi-domain] Cd Length: 378 Bit Score: 55.78 E-value: 1.96e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 7 MCYSILGPFFPKEAEkkgtSNTIIGMIFGCFALFELLACLVFGNYLVHIGAKFMFVAG---MFVSGGVTIL---FGVLdr 80
Cdd:cd17383 13 MLYMVIVPIIPDYLN----EDIAIGVLFASKAIVQLLVNPFSGTLIDRVGYDIPMMIGltvMFLSTAVFAFgesYAVL-- 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 81 vpdgpvfiamcFLVRVMDAVSFAAAVTASSSILAKAFP--NNVATVLGSLETFSGLGLILGPPVGGFLYQSFGYEVPFIV 158
Cdd:cd17383 87 -----------FFARSLQGVGSAFADTAGLAMIADRFTeeAERSKALGIALAFISFGCLVAPPFGGILYEFAGKEVPFLI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 159 LGCIILLMVPLNMYILPNYESDPGEHS-------FWKLIALPkvgLIAFVINSLSSC---FGFLDPTLSLFVLEKFNLPA 228
Cdd:cd17383 156 LAFVCLLDGLLLLLVMKPVRRETRANMpepvgtpIHRLLMDP---YIAVCAGALTMAnvsLAFLEPTIANWMKDTMNASE 232
|
....*...
gi 1622928889 229 GYVGLVFL 236
Cdd:cd17383 233 WQMGLVWL 240
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
5-286 |
1.23e-07 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 52.89 E-value: 1.23e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 5 SMMCYSILGPFFPKEAEKKGTSNTIIGMIFGCFALFELLACLVFGNYLVHIGAKFMFVAGMFVSGGVTILFGVLdrvPDG 84
Cdd:COG0477 26 EGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLA---PSP 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 85 PVFIAMcflvRVMDAVSFAAAVTASSSILAKAFPNNV-ATVLGSLETFSGLGLILGPPVGGFLYQSFGYEVPFIVLGCII 163
Cdd:COG0477 103 ELLIAA----RALQGIGAGGLMPGALALIAELFPARErGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLG 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 164 LLMVPLNMYIlpnyesdpGEHSFWKLIALPKVGLIAFVINSLSSCFGFLDPTLSLFVLEKFNLPAGYVGLVFLGLALSYA 243
Cdd:COG0477 179 LLALVLRLRL--------PESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLAL 250
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 1622928889 244 ISSPLFGLLSDKMPPLRKWLLVFGNLITAGCYILLGPVPVLHI 286
Cdd:COG0477 251 LLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLAL 293
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
7-384 |
1.64e-07 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 53.00 E-value: 1.64e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 7 MCYSILGPFFPKE-AEKKGTSNTIIGMIFGCFALFELLACLVFGNYLVHIGAKFMFVAGMFVSGGVTILFGVLDRVPdgp 85
Cdd:cd17329 13 LGFFMVWPFMAIYlHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPW--- 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 86 VFIAMCFLVRVMDAVSFaaavTASSSILAKAFPN-NVATVLGSLETFSGLGLILGPPVGGFLYQsFGYEVPFIVLGCIIL 164
Cdd:cd17329 90 LFAIALVLTGFGGGLFE----PASEAMIADVTTPeNRTRAFSLLYWAINLGVAIGPLLGGLLLL-YSFRLLFLAAAVLFL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 165 LMVPLNMYILPNYESDPGEHSF------WKLIALPKVGLIAFVINSL-SSCFGFLDPTLSLFVLEKFNLPAGYVGLVFLG 237
Cdd:cd17329 165 LAALVLLFLLPETRPKRRAAEKteilrgYKIVLRDRAFLLFLLASFLiSLIYFQLESTLPVYVVEILGLGESLLGLLLAL 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 238 LALSYAISSPLFGLLSDKMPPLRkwLLVFGNLITAGCYILLGPVPVLhiksqlwllvlilvvnGISAGMSIIPTFPEILS 317
Cdd:cd17329 245 NALLIVLLQFPVARLVERFRLRK--ILMIGILLFAIGFAVLAFANTL----------------AVLILAMIVLTLGEMLV 306
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 318 CAHENGFEEGLS---TLGLVSGLFSAMWSIGAFLGPTLGGFLYEKIGFEWAAAIQGLWALISGLAMGLFY 384
Cdd:cd17329 307 FPAVQTLVAALAppdKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGLQ 376
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
198-383 |
3.12e-07 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 52.04 E-value: 3.12e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 198 IAFVINSLSSCFGFLDPTLSLFVLEKFNLPAGYVGLVFLGLALSYAISSPLFGLLSDKMPplRKWLLVFGNLITAGCYIL 277
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFG--RRRVLLIGLLLFALGLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 278 LGPVpvlhikSQLWLLVLILVVNGISAGMSIIPTFPEILSCAHEngfeeglSTLGLVSGLFSAMWSIGAFLGPTLGGFLY 357
Cdd:pfam07690 79 LLFA------SSLWLLLVLRVLQGLGAGALFPAALALIADWFPP-------EERGRALGLVSAGFGLGAALGPLLGGLLA 145
|
170 180
....*....|....*....|....*.
gi 1622928889 358 EKIGFEWAAAIQGLWALISGLAMGLF 383
Cdd:pfam07690 146 SLFGWRAAFLILAILSLLAAVLLLLP 171
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
184-410 |
4.20e-07 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 51.51 E-value: 4.20e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 184 HSFWKLIALPKVGLIAFVInslSSCFGFLDPTLSLFVLEkFNLPAGYVGLVFLGLALSYAISSPLFGLLSDKMPplRKWL 263
Cdd:COG2814 4 TPRRRWLALLALALGAFLS---GLGIGIVLPALPLIAAD-LGASPAQAGLVVTAYLLGAALGAPLAGRLADRFG--RRRV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 264 LVFGNLITAGCYILLGPVPVLHIksqlwlLVLILVVNGISAGMSIIPTFPEILSCAHEngfeeglSTLGLVSGLFSAMWS 343
Cdd:COG2814 78 LLLGLLLFALGSLLCALAPSLWL------LLAARFLQGLGAGALFPAALALIADLVPP-------ERRGRALGLLGAGLG 144
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622928889 344 IGAFLGPTLGGFLYEKIGFEWAAAIQGLWALISGLAMGLFYLLEYSRRRRSKSQNILSTEEERTTLL 410
Cdd:COG2814 145 LGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELLRRPRLLL 211
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
12-386 |
2.49e-06 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 49.10 E-value: 2.49e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 12 LGPFFPKEAEKKGTSNTIIGMIFG----CFALFELLAclvfGNYLVHIGAKFMFVAGMFVSGGVTILFGVldrVPDGPVF 87
Cdd:COG2807 37 VGPLLPEIRADLGLSATQAGLLTTlpllAFGLFAPLA----PRLARRFGLERTLLLALLLLAAGLLLRSL---APSVALL 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 88 IAMCFLVrvmdAVSFAAAVTASSSILAKAFPNNVATVLGSLETFSGLGLILGPPVGGFLYQSFGYEVPFIVLGCIILLMV 167
Cdd:COG2807 110 LAGTALI----GAGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLAL 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 168 PLNMYILPNYESDPGE-------HSFWKLIALPKVGLIAFVINSLSSC-FGFLDPtlslfVLEKFNLPAGYVGLVFLGLA 239
Cdd:COG2807 186 LLWLPLLRRRPAAAAAapaaaslRSLWRSPLAWLLTLFFGLQSLLYYAvVAWLPP-----ILRDAGLSAATAGLLLSLFQ 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 240 LSYAISSPLFGLLSDKMPPLRKWLLVFGNLITAGCYILL---GPVPVLHIksqlwllvlilvvngISAGMSIIPTFPeiL 316
Cdd:COG2807 261 LAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLlapGSLPWLWA---------------VLLGLGQGGLFP--L 323
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 317 SCAHENGFEEGLSTLGLVSGLFSAMWSIGAFLGPTLGGFLYEKIGfEWAAAIqgLWALISGLAMGLFYLL 386
Cdd:COG2807 324 ALTLIGLRARTPAEAAALSGMAQSVGYLLAALGPLLVGALHDATG-SWTAAL--LLLAALAVLMLVAGLL 390
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
1-278 |
4.29e-06 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 48.31 E-value: 4.29e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 1 MNLGSMMCYSILGPFFPK-EAEKKGTSNTIIGMIFGCFALFELLACLVFGNYL-VHIGAKFMFVAGMFVSGGVTILFGVL 78
Cdd:cd17471 4 ATLLTGLAGAFVLPYLSLfLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSdRGGDRKPLILLALLAGALGYLLFAFL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 79 DrvpDGPVFIAMCFLVRVMDAVSFAAAVTASSSILAKAFPNNVATVLGSLETFSGLGLILGPPVGGFLYQSFGYEVPFIV 158
Cdd:cd17471 84 R---NYWVLLLVGVVLLSLGAAAFPQLFALAREYADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 159 LGCIILLMVPLNMYILPNYESDPGE----HSFWKLIALPKVGLIAFVINSLSSCFGFLDPTLSLFVLEKFNLPAGYVGLV 234
Cdd:cd17471 161 AALLYLVVALLVLFLLPSVKPPAQKatpaSSLVKAPVNRRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSESWVGLL 240
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 1622928889 235 FlglALSYAISSP---LFGLLSDKMPplRKWLLVFGNLITAGCYILL 278
Cdd:cd17471 241 F---GLAAALEIPimlLAGLLAKRFG--KRRLLLAGFLAGVLFYLGL 282
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
24-379 |
7.89e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 47.61 E-value: 7.89e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 24 GTSNTIIGMIFGCFALFELLACLVFGNYLVHIGAKFMFVAGMFVSGGVTILFGVL---DRVPDGPVFIAMcFLVRVMDAV 100
Cdd:cd06173 30 TGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLallGSLSLWLLLVLA-FLLGIASAF 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 101 SFAAAVTASSSILAKafpNNVATVLGSLETFSGLGLILGPPVGGFLYQSFGYEVPFIVLGCIILLMVPLNMYILPNYESD 180
Cdd:cd06173 109 FGPARQALLPELVPK---EQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAA 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 181 PGEHSFWKLIAL---------PKVGLIAFVINSLSSCFGFLDPTLS-LFVLEKFNLPAGYVGLVFLGLALSYAISSPLFG 250
Cdd:cd06173 186 PGESSSLLLRDLreglrylrrSPLLRLLLLALALFALLGGALTVLLpLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLG 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 251 LLSDKMPPLRkwLLVFGNLITAGCYILLGPVPVLhiksqlWLLVLILVVNGISAGMSIIPTFPEILSCAHENgfeeglsT 330
Cdd:cd06173 266 RLSKRRRRGR--LLLIGALLLGLALLVLGLSPSL------WLLLAALFLLGLAGGLFNVPLNTLLQLRVPDE-------L 330
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1622928889 331 LGLVSGLFSAMWSIGAFLGPTLGGFLYEKIGFEWAAAIQGLWALISGLA 379
Cdd:cd06173 331 RGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALL 379
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
215-410 |
1.11e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 47.22 E-value: 1.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 215 TLSLFVLEKFNLPAgYVGLVFLGLALSYAISSPLFGLLSDKMPplRKWLLVFGNLITAGCyILLGPVPVLHIKSQLWLLV 294
Cdd:cd06173 21 ALPWLVLQLTGSAL-LVGLVLAAFFLPFLLFSPFAGVLADRFD--RRRLLILADLLRALL-AAVLALLALLGSLSLWLLL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 295 LILVVNGISAGMSIIP---TFPEILScahengfEEGLSTLglvSGLFSAMWSIGAFLGPTLGGFLYEKIGFEWAAAIQGL 371
Cdd:cd06173 97 VLAFLLGIASAFFGPArqaLLPELVP-------KEQLVRA---NALNSLATQLARIIGPALGGLLVALLGPGGAFAINAL 166
|
170 180 190
....*....|....*....|....*....|....*....
gi 1622928889 372 WALISGLAMGLFYLLEYSRRRRSKSQNILSTEEERTTLL 410
Cdd:cd06173 167 SFLLSALLLLFIRRPPPAAPGESSSLLLRDLREGLRYLR 205
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
20-175 |
1.12e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 47.17 E-value: 1.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 20 AEKKGTSNTIIGMIFGCFALFELLACLVFGNYLVHIGAKFMFVAgMFVSGGVTILFGVLDRVPDGPVFIAMCFLVrvmdA 99
Cdd:COG2271 208 VEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVL-AIGLLLAALALLLLALLPSPALAIALLFLA----G 282
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622928889 100 VSFAAAVTASSSILAKAFP-NNVATVLGSLETFSGLGLILGPPVGGFLYQSFGYEVPFIVLGCIILLMVPLNMYILP 175
Cdd:COG2271 283 FGLGGAFGLLWALAAELFPkKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLR 359
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
10-277 |
1.25e-05 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 46.87 E-value: 1.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 10 SILGPFFPKEAEKKG-TSNTII----GMIFGCFALFELLACLVFGNYLVHIGAKFMFVAGMFvsgGVTILFGVLDRVPDG 84
Cdd:cd17391 13 SLIAPFLPLYIEQLGvTSGGLVelwsGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASL---GMAIVIGLMAFVTNV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 85 PVFIAMCFLVRVmdavsFAAAVTASSSILAKAFPNNVA-TVLGSLETFSGLGLILGPPVGGFLYQSFGYEVPFIVLGCII 163
Cdd:cd17391 90 WQLLILRLLQGV-----FSGYVPNATALIASQTPKEKSgWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 164 LLMVPLNMYIL------PNYESDPGEHSFWKLIALPKVGLIAFVINSLS-SCFGFLDPTLSLFVlEKFNLPAGYV----G 232
Cdd:cd17391 165 FLAFLLTLFFVkedfkpVEKKKMVSTKEVWNSVPNPSLLISLFVTTFIIqLANQSIEPILTLYI-RQLMGDASNLafisG 243
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 1622928889 233 LVFLGLALSYAISSPLFGLLSDKMPPLRkwLLVFGNLITAGCYIL 277
Cdd:cd17391 244 LVFSATGVSSLLSAPRLGKLGDRIGHHR--ILLGALLASALLYIP 286
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
12-378 |
1.46e-05 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 46.88 E-value: 1.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 12 LGPFFPKEAEKKGTSNTIIGMIFGCFALFELLACLVFGNYLVHIGAKFMFVAGMFVSGGVTILFGVldrVPDGPVFIAMC 91
Cdd:cd17355 22 FGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLAL---ATSLWQLYLLW 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 92 FLVRVMDAVSFAAAVTASssILAKAFPNNVATVLGSLETFSGLGLILGPPVGGFLYQSFGYEVPFIVLGCIILLMVPLNM 171
Cdd:cd17355 99 GLLGGGGAGTLAAVAFAT--VAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 172 YILPNYESDPGEHSFW--KLIALPKVGLIAF--------VINSLSSCFGFLDPTLSLFV-LEKFNLPAGYVGLVFLGLAL 240
Cdd:cd17355 177 LLLRRRPADLALRAYDdaSPASPGSTLKEALrsasfwllALAFFLCGFAVVGLIVHLVPyLADRGISPAAAAVALALIGL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 241 SYAISSPLFGLLSDKMPPLRKWLLVFG-NLITAGCYILLGPVPvlhiksqlWLLVLILVVNGISAGMSIIPTfpeILSCA 319
Cdd:cd17355 257 FNIVGRLLSGWLGDRYSPRRLLAASYAlRALGLALLLLLPFPP--------LALLLFAALFGLGWGATVPLT---AALAA 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 320 HENGFEEglstLGLVSGLFSAMWSIGAFLGPTLGGFLYEKIG-FEWAAAIQGLWALISGL 378
Cdd:cd17355 326 RYFGARS----YGTLFGLVFAPHQLGSALGPWLGGLLYDRTGsYTAAWALAVALGLIAAL 381
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
209-401 |
2.33e-05 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 46.00 E-value: 2.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 209 FGFLDPTLSLFVLEKFNLPAGYVGLVFLGLALSYAISSPLFGLLSDKMPPlRKWLLVFGNLITAGCYILLGpvpvlHIKS 288
Cdd:cd17471 12 GAFVLPYLSLFLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRGGD-RKPLILLALLAGALGYLLFA-----FLRN 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 289 QLWLLVLILVVNGISAgmsiiPTFPEILSCAHENGFEEGLSTLGLVSGLFSAMWSIGAFLGPTLGGFLYEKIGFEWAAAI 368
Cdd:cd17471 86 YWVLLLVGVVLLSLGA-----AAFPQLFALAREYADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLL 160
|
170 180 190
....*....|....*....|....*....|...
gi 1622928889 369 QGLWALISGLAmgLFYLLEYSRRRRSKSQNILS 401
Cdd:cd17471 161 AALLYLVVALL--VLFLLPSVKPPAQKATPASS 191
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
6-382 |
2.35e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 46.06 E-value: 2.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 6 MMCYSILGPFFpKEAEKKGTSNTIIGMIFGCFALFELLACLVFGNYLVHIGAKFMFVAGMFVSGGVTILFGVLdrvpdgP 85
Cdd:cd17316 15 FFLIGFVAPVL-AAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLL------P 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 86 VFIAMcFLVRVMDAVSFAAAVTASSSILAKAFP-NNVATVLGSLETFSGLGLILGPPVGGFLYQSFGYE----VPFIVLG 160
Cdd:cd17316 88 TPILL-LVLRFLQGIGIGGEYPGASTYVAEFAPsKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDwgwrILFLIGA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 161 CIILLMVPLNMYILpnyesdpgehsfwklialpKVGLIAFVINSLSSCFGFLDPTLSLFVLekfNLPAGYVGLVFLGLAL 240
Cdd:cd17316 167 LPALLALLLRRRTL-------------------LLILLWFFISFGYYGLTTFLPTYLQTVL---GLSPATSSLYLLLISL 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 241 SYAISSPLFGLLSDKMPplRKWLLVFGNLITAGCYILLGPVPVLHIKSQLWLLVLILVVNGISAGMSIIpTFPEILScah 320
Cdd:cd17316 225 GALVGALIAGLLSDRIG--RKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYA-YLAELFP--- 298
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622928889 321 engfeegLSTLGLVSGLFSAMWSIGAFLGPTLGGFLYEKIGFEWAAAIQGLWALISGLAMGL 382
Cdd:cd17316 299 -------TEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
10-234 |
2.42e-05 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 46.07 E-value: 2.42e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 10 SILGPFFPKEAEKKGTSNTIIGMIFGCFALFELLACLVFGNYLVHIGAKFMFVAGMFVSGGVTILFGVldrvpdgPVFIA 89
Cdd:cd17390 13 SMILPLLSTHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGF-------STSLA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 90 MCFLVRVMDAVsFAAAVTASSSILAKAFPNN-VATVLGSLETFSGLGLILGPPVGGFLYQ-SFGYEVPFIVLGCIILLMV 167
Cdd:cd17390 86 LLFLSRIPLGI-FKHTQSLCKAYLSDLVSEQeRSRVLGRFNAASSLGFILGPVVGGHLAEtDGGFYYVALLCSAIFILNA 164
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622928889 168 PLNMYILPNYesdpgehsfWKLIALPKvgLIAFVINSLSSCFgfldptlSLFVLEKFNLPAGYVGLV 234
Cdd:cd17390 165 GLVWFLLSKL---------WDLLLVRF--LMGFSVLLFRSNF-------SLYLEERFDLSPKTIGYL 213
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
7-379 |
5.88e-05 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 44.85 E-value: 5.88e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 7 MCYSILGPFFPKEAEKKGTSNTIIGMIFGCFALFELLACLVFGNYLVHIGAKFMFVAGMFVSGGVTILFGVldrVPDGPV 86
Cdd:cd17478 10 FYQGFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGF---APNYWL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 87 FIAMCFLVrvmdAVSFAAAVTASSSILAKAFPNNVATVLGSLETFSGLGLILGPPVGGFLYQSFGYE-------VPFIVL 159
Cdd:cd17478 87 LLLLVALA----GIGSAAFHPEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLgllilliIPGLAV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 160 GCIILLMVPLNMYILPNYESDPGEHSFWKLIALPkVGLIAFVINSLSSCFGFLDPTLSLFVLEKF--NLPAGYVGLVFLG 237
Cdd:cd17478 163 ALLLLRLRPLKKPEAKKAAAKSSARSTLKGVWRA-LLLLLIIVFLRSWVLSSLTTFLPFYLVQRGysLVFAGLLLSLFLF 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 238 LAlsyAISSPLFGLLSDKMPplRKWLLVFGNLITAGCYILLgpvpvlhIKSQLWLLVLILVVNGISAGMSiiptFPEILS 317
Cdd:cd17478 242 AG---AIGTLIGGPLSDRFG--RRRVIIASLLLAAPFLLLF-------LLTPGIWSYILLVLAGFLLFAS----FPVTVV 305
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622928889 318 CAHENGFEeglsTLGLVSGLFSA-MWSIGAFLGPTLgGFLYEKIGFEWAAAIQGLWALISGLA 379
Cdd:cd17478 306 LAQELLPG----NVGLASGLMMGlSFGLGGIGAPVL-GALADAFGLESVLLILALLPLLGALL 363
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
1-380 |
2.37e-04 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 42.98 E-value: 2.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 1 MNLGSMMCYSIlgpFFPKEAEKKGTSNTIIGMIFGCFALFELLACLVFGNYLVHIGAKFMFVAGMFVSGGVTILFGVLDR 80
Cdd:cd17353 14 LILGYQYAWSV---FNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAIS 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 81 VPdgPVFIAMCFLVRVMDAVSFAAAVtassSILAKAFPNNVATVLGSLETFSGLGLILGPPVGGFLYQSFGYEVPFIVLG 160
Cdd:cd17353 91 LP--LLFLGYGVLGGIGAGIGYITPV----STAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILG 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 161 CIILLMVPLNMYIL----------------PNYESDPGEHSFWKLIALPKVGLIAFVINSLSSCFGFLDPTLSLFVLEKF 224
Cdd:cd17353 165 IIFLIIIVIGAFLIrdppkgwvppgvdplaNNAENSPRDYTPREMLRTPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 225 NLPAGYVGLVFLGLALSYAISSPLFGLLSDKMPPLRKWLLVFgnLITAGCYILLgpvpvLHIKSQLWLLVLILVVNGISA 304
Cdd:cd17353 245 GLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAF--LIQGVAMFLL-----PFIGSVAVLFVLGVALIGFCY 317
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622928889 305 GmSIIPTFPEILScaheNGFeeGLSTLGLVSGLFSAMWSIGAFLGPTLGGFLYEKIGFEWAAAIQGLWALISGLAM 380
Cdd:cd17353 318 G-GGFALFPALTA----DFF--GTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALALA 386
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
12-167 |
4.24e-04 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 42.26 E-value: 4.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 12 LGPFFPKEAEKKGTSNTIIGMIFGCFALFELLACLVFGNYLVHIGAKFMFVAGMFVSGGVTILFGVLDRVPDGPVFIAMC 91
Cdd:cd17312 22 FSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLN 101
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622928889 92 FLVRVMDAVSFAAAVTASSSilakafPNNVATVLGSLETFSGLGLILGPPVGGFLYQSFGYEVPFIVLGCIILLMV 167
Cdd:cd17312 102 GLFQSMGWPPCVKLLGNWFS------KKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVA 171
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
209-386 |
5.32e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 42.20 E-value: 5.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 209 FGFLDPTLSLFVLEKFNLPAGYVGLVFLGLALSYAISSPLFGLLSDKMPPL---RKWLLVFGNLITAGCYILLGPVPVLH 285
Cdd:COG2211 26 FGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRwgrRRPWILIGAIPLALSFVLLFTAPDLS 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 286 IKSQLWLLVLILVVNGISAGMSIIPT---FPEILSCAHEngfeeglstLGLVSGLFSAMWSIGAFLGPTLGGFLYEKIGF 362
Cdd:COG2211 106 PTGKLIYALVTYLLLGLAYTLVNIPYsalGAELTPDYEE---------RTRLSSWRFAFAGLGGLLASVLPPPLVAAFGG 176
|
170 180
....*....|....*....|....
gi 1622928889 363 EWAAAIQgLWALISGLAMGLFYLL 386
Cdd:COG2211 177 DAALGYR-LTALIFAVLGLLAFLL 199
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
55-182 |
5.35e-04 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 41.94 E-value: 5.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 55 IGAKFMFVAGMFVSGGVTILFGVLDRVPdgpVFIAMCFLvrvmDAVSFAAAVTASSSILAKAF-PNNVATVLGSLETFSG 133
Cdd:cd17343 65 ISARWLFSSGLVLSGLTTVAFSGSSSVW---VFSILWFL----NGLAQGLGWPPCAKILRKWFsPSQFGTWWSVLSTSMN 137
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1622928889 134 LGLILGPPVGGFLYQSFGYEVPFIVLGCIILLMVPLNMYILPNYESDPG 182
Cdd:cd17343 138 LAGSLGPILATLLALSYGWRSTLSISGTVAVVMSVVCLLFIKNEPSDVG 186
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
210-397 |
5.53e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 41.77 E-value: 5.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 210 GFLDPTLSLFVlEKFNLPAGYVGLVFLGLALSYAISSPLFGLLSDKMPplRKWLLVFGNLITAGCYILLGPVPVLhiksq 289
Cdd:cd17478 13 GFLPALLPLLI-AKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKP--RRYLLPLGPLLTGLGLSLLGFAPNY----- 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 290 lWLLVLILVVNGISAGMsiiptF-PEILSCAHENGFEEglstLGLVSGLFSAMWSIGAFLGPTLGGFLYEKigfeWAAAI 368
Cdd:cd17478 85 -WLLLLLVALAGIGSAA-----FhPEGARLASQAAGGR----RGLAMSIFSVGGNLGFALGPLIAAALVAL----FGGLG 150
|
170 180
....*....|....*....|....*....
gi 1622928889 369 QGLWALISGLAMGLFYLLEYSRRRRSKSQ 397
Cdd:cd17478 151 LLILLIIPGLAVALLLLRLRPLKKPEAKK 179
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
5-393 |
5.72e-04 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 41.79 E-value: 5.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 5 SMMCYSILGPFFPKEAEKKGTSNTIIGMIFGCFALFELLACLVFGNYLVHIGAKFMFVAGMFVSGGVTILFGVldrVPDg 84
Cdd:cd17323 11 VTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCAL---APN- 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 85 pvfIAMCFLVRVMDAVSFAAAVTASSSILAKAF-PNNVATVLGSLETFSGLGLILGPPVGGFLYQSFGYEVPFIVL---- 159
Cdd:cd17323 87 ---IAMLIILRFLQGFFGSSPLAIGAGTIADLFtPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLaiis 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 160 GCIILLMVPLnmyilpnyesdpgehsfwkliaLPKVGLIAFVINSLSSCFGFLDPTLSLFVLEKFNLPAGYVGLVFLGLA 239
Cdd:cd17323 164 GFCLILIFLF----------------------LPIVLLLGLYVGLVYAILYLFLTAFPYVFGEVYGFSPGEVGLMYLPIG 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 240 LSYAISSPLFGLLSDK-------------MPPLRKWLLVFGNLITAGCYILLG--PVPVLHIKSQLWLLVLIlvvnGISA 304
Cdd:cd17323 222 IGALIGSIIGGRLSDYyyrrlkkknggkpEPEARLPPAFIGAFLFPIGLFIFGwtIYPHIHWIVPIIGSAFF----GFGL 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 305 GMSIIPTFPEILSCAHENGfeeglstlGLVSGLFSAMWSIGAFLGPTLGGFLYEKIGFEWAAAIQGLWALISGLamGLFY 384
Cdd:cd17323 298 MLIFQSSLTYLVDSYPKYA--------ASALAANTLVRSIFAAIFPLFAQPMFNNLGVGWAFTLLAFISLAMIP--IPFI 367
|
....*....
gi 1622928889 385 LLEYSRRRR 393
Cdd:cd17323 368 FYKYGKKIR 376
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
88-281 |
1.24e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 40.64 E-value: 1.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 88 IAMCFLVRVMDAVSFAAAVTASSSILAKAFPNN-VATVLGSLETFSGLGLILGPPVGGFLYQSFGYEVPFIV---LGCII 163
Cdd:cd17503 84 LASLIIFRILQGFGGGVLIPLAQTILLRIYPPEkRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYInlpIGILA 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 164 LLMVP-LNMYILpnyesdpgehsfwKLIALPKVGLIAFVINSLSSCFGFLdptLSLFVLEKFNLPAGYVGLVFLGLALSY 242
Cdd:cd17503 164 LLLAPlLDLRLF-------------KDRNFTLGLLLSFLLGLGLFGAMFL---LPLYLQNVLGYSAFESGLVLAPGGLAS 227
|
170 180 190
....*....|....*....|....*....|....*....
gi 1622928889 243 AISSPLFGLLSDKMPPlrKWLLVFGNLITAGCYILLGPV 281
Cdd:cd17503 228 AILSPLVGRLLDKFGP--RLLLLAGLLLLALGTLLLAFL 264
|
|
| PRK03545 |
PRK03545 |
putative arabinose transporter; Provisional |
125-281 |
2.64e-03 |
|
putative arabinose transporter; Provisional
Pssm-ID: 179591 [Multi-domain] Cd Length: 390 Bit Score: 39.87 E-value: 2.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 125 LGSLETFSGLGLILGPPVGGFLYQSFGYEVPFIVLGCIILLMVPLNMYILPNYESdpgEH--SFWKLIALPK-------V 195
Cdd:PRK03545 135 LSLLATGTALAMVLGLPLGRVIGQYLGWRTTFLAIGGGALITLLLLIKLLPLLPS---EHsgSLKSLPLLFRrpalvslY 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 196 GLIAFVINSLSSCFGFLDPtlslFVLEKFNLPAGYVGLVFLGLALSYAISSPLFGLLSDKMPplrKWLLVFGNLITAGCY 275
Cdd:PRK03545 212 LLTVVVVTAHFTAYSYIEP----FVQQVAGLSENFATLLLLLFGGAGIIGSVLFSRLGNRHP---SGFLLIAIALLLVCL 284
|
....*.
gi 1622928889 276 ILLGPV 281
Cdd:PRK03545 285 LLLLPA 290
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
30-169 |
5.37e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 38.71 E-value: 5.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 30 IGMIFGCFALFELLACLVFGNYLV-HIGAKFMFVAGMFVSGgvtILFGVLDRVPDGPVFIAMCFLVRVMDAVsfaaAVTA 108
Cdd:cd17330 212 IGLLLALVGIAGILAQLLLIPRLAkRLGERKLLRLGLLLAI---IGLLLLPFASSVPLLVLAAAILAFGTGI----VFPA 284
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622928889 109 SSSILAKAFP-NNVATVLGSLETFSGLGLILGPPVGGFLYQSFGYEVPFIVLGCIILLMVPL 169
Cdd:cd17330 285 LSALLSKSVPsKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFL 346
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
9-174 |
5.69e-03 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 38.75 E-value: 5.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 9 YSILGPFFPKEAEKKGTS-----NTIIGMIFGCFALFELLACLVFGNYLVHIGAKFMFVAGMFVSGGVTILFGVLDRVPD 83
Cdd:PRK09874 30 FSLVMPFLPLYVEQLGVTghsalNMWSGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQ 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928889 84 GPVFIAMCFLVrvmdavsfAAAVTASSSILAKAFPNNVAT-VLGSLETFSGLGLILGPPVGGFLYQSFGYEVPFIVLGCI 162
Cdd:PRK09874 110 FLILRALLGLL--------GGFVPNANALIATQVPRNKSGwALGTLSTGGVSGALLGPLAGGLLADSYGLRPVFFITASV 181
|
170
....*....|..
gi 1622928889 163 ILLMVPLNMYIL 174
Cdd:PRK09874 182 LFLCFLVTLFCI 193
|
|
| |
