NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|966940052|ref|XP_014992441|]
View 

kelch-like protein 32 isoform X4 [Macaca mulatta]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
BACK_KLHL32_BKLHD5 cd18471
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also ...
 35-132 1.65e-63

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also termed BTB and kelch domain-containing protein 5 (BKLHD5), belongs to the KLHL family. Its function remains unclear. KLHL32 SNPs may be associated with body mass index in individuals of African ancestry.


:

Pssm-ID: 350546 [Multi-domain]  Cd Length: 98  Bit Score: 201.67  E-value: 1.65e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052  35 LNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSRPEDVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHN 114
Cdd:cd18471    1 LNSFNYLDLYKLADLFNLTLLEEAVVDFLVKHLSELLKSHPEEVLALPYRLLREVLKSDRLTSLSEEQIWQLAVRWLEHN 80

                         90
                 ....*....|....*...
gi 966940052 115 CHYQHMDELLQYIRFGLM 132
Cdd:cd18471   81 CRYQYMDELLQYVRFGLM 98
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
220-491 1.19e-39

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 144.91  E-value: 1.19e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052 220 ANWSELAPMPVGRSHHCVAVMGDFLFVAGGeveHASGRtcAVRTACRYDPRSNSWAEIAPMKNC-REHFVLGAMEEYLYA 298
Cdd:COG3055    1 ATWSSLPDLPTPRSEAAAALLDGKVYVAGG---LSGGS--ASNSFEVYDPATNTWSELAPLPGPpRHHAAAVAQDGKLYV 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052 299 VGGRNEL---RQVLPTVERYCPKKNKWTFVQSFDRSLSCHAGYVADGLLWISGGVTNTAqYQNRLMVYEPNQNKWISRSP 375
Cdd:COG3055   76 FGGFTGAnpsSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGG-NVAWVEVYDPATGTWTQLAP 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052 376 MLQRRVYHSMAAV-ERKLYVLGGndldynndrilvrhiDSYNIDTDQWTRCSfNLLTGQNESGVAVHNGRIYLVGGYSIW 454
Cdd:COG3055  155 LPTPRDHLAAAVLpDGKILVIGG---------------RNGSGFSNTWTTLA-PLPTARAGHAAAVLGGKILVFGGESGF 218

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 966940052 455 TNEplacIQVLDVSREGKEEVfygPTLPFASNGIAAC 491
Cdd:COG3055  219 SDE----VEAYDPATNTWTAL---GELPTPRHGHAAV 248
Kelch smart00612
Kelch domain;
187-242 1.11e-05

Kelch domain;


:

Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 42.55  E-value: 1.11e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 966940052   187 LYIIGGKKREVCkVKELRYFNPVDQEnaliaaianWSELAPMPVGRSHHCVAVMGD 242
Cdd:smart00612   2 IYVVGGFDGGQR-LKSVEVYDPETNK---------WTPLPSMPTPRSGHGVAVING 47
 
Name Accession Description Interval E-value
BACK_KLHL32_BKLHD5 cd18471
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also ...
 35-132 1.65e-63

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also termed BTB and kelch domain-containing protein 5 (BKLHD5), belongs to the KLHL family. Its function remains unclear. KLHL32 SNPs may be associated with body mass index in individuals of African ancestry.


Pssm-ID: 350546 [Multi-domain]  Cd Length: 98  Bit Score: 201.67  E-value: 1.65e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052  35 LNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSRPEDVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHN 114
Cdd:cd18471    1 LNSFNYLDLYKLADLFNLTLLEEAVVDFLVKHLSELLKSHPEEVLALPYRLLREVLKSDRLTSLSEEQIWQLAVRWLEHN 80

                         90
                 ....*....|....*...
gi 966940052 115 CHYQHMDELLQYIRFGLM 132
Cdd:cd18471   81 CRYQYMDELLQYVRFGLM 98
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
220-491 1.19e-39

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 144.91  E-value: 1.19e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052 220 ANWSELAPMPVGRSHHCVAVMGDFLFVAGGeveHASGRtcAVRTACRYDPRSNSWAEIAPMKNC-REHFVLGAMEEYLYA 298
Cdd:COG3055    1 ATWSSLPDLPTPRSEAAAALLDGKVYVAGG---LSGGS--ASNSFEVYDPATNTWSELAPLPGPpRHHAAAVAQDGKLYV 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052 299 VGGRNEL---RQVLPTVERYCPKKNKWTFVQSFDRSLSCHAGYVADGLLWISGGVTNTAqYQNRLMVYEPNQNKWISRSP 375
Cdd:COG3055   76 FGGFTGAnpsSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGG-NVAWVEVYDPATGTWTQLAP 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052 376 MLQRRVYHSMAAV-ERKLYVLGGndldynndrilvrhiDSYNIDTDQWTRCSfNLLTGQNESGVAVHNGRIYLVGGYSIW 454
Cdd:COG3055  155 LPTPRDHLAAAVLpDGKILVIGG---------------RNGSGFSNTWTTLA-PLPTARAGHAAAVLGGKILVFGGESGF 218

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 966940052 455 TNEplacIQVLDVSREGKEEVfygPTLPFASNGIAAC 491
Cdd:COG3055  219 SDE----VEAYDPATNTWTAL---GELPTPRHGHAAV 248
PHA03098 PHA03098
kelch-like protein; Provisional
 25-486 4.43e-30

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 123.34  E-value: 4.43e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052  25 VLSTCQTFM--ELNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSrpEDVLTLPYCLLQEVLKSDRLTSLSEEQ 102
Cdd:PHA03098  93 LINLCINYIikIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYND--PDFIYLSKNELIKILSDDKLNVSSEDV 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052 103 IWQLAVRWLEH--NCHYQHMDELLQYIRFGLMDVDTLHTVALSHPLVQASetaTALVNEALE---YHQSIYAQPVWQTRR 177
Cdd:PHA03098 171 VLEIIIKWLTSkkNNKYKDICLILKVLRITFLSEEGIKKLKRWKLRIKKK---KIVFNKRCIkiiYSKKYNLNKILPRSS 247

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052 178 TKPRFQSDTLYIIGGKKREVCKVKELRYFNPVDQENAliaaianwselapmpvgRSHHCVAVMGDFLFVAGGEVEhasgR 257
Cdd:PHA03098 248 TFGSIIYIHITMSIFTYNYITNYSPLSEINTIIDIHY-----------------VYCFGSVVLNNVIYFIGGMNK----N 306

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052 258 TCAVRTACRYDPRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRnELRQVLPTVERYCPKKNKWTFVQS--FDRSLSCH 335
Cdd:PHA03098 307 NLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGI-YNSISLNTVESWKPGESKWREEPPliFPRYNPCV 385

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052 336 AGYvaDGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVERKLYVLGGndLDYNNDRILVRHIDSY 415
Cdd:PHA03098 386 VNV--NNLIYVIGGISKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGG--ISYIDNIKVYNIVESY 461

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966940052 416 NIDTDQWTRCSFNLLTGQNESGVAVHNgRIYLVGGYSI--WTNEplacIQVLDVsrEGKEEVFYGPTLPFASN 486
Cdd:PHA03098 462 NPVTNKWTELSSLNFPRINASLCIFNN-KIYVVGGDKYeyYINE----IEVYDD--KTNTWTLFCKFPKVIGS 527
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 40-140 3.69e-25

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 99.34  E-value: 3.69e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052    40 YLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSrpEDVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHNC--HY 117
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSS--EEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPekRR 78

                           90       100
                   ....*....|....*....|...
gi 966940052   118 QHMDELLQYIRFGLMDVDTLHTV 140
Cdd:smart00875  79 EHLPELLEHVRLPLLSPDYLLEV 101
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 41-140 2.35e-19

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 82.98  E-value: 2.35e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052   41 LDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSrpEDVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHN--CHYQ 118
Cdd:pfam07707   2 LGIYRFADAYGCTELAEAALRFILQNFLEVAKS--EEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDveRRKK 79

                          90       100
                  ....*....|....*....|..
gi 966940052  119 HMDELLQYIRFGLMDVDTLHTV 140
Cdd:pfam07707  80 HLPELLSAVRLPLLSPQYLLNL 101
Kelch_6 pfam13964
Kelch motif;
232-284 9.04e-07

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 45.79  E-value: 9.04e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 966940052  232 RSHHCVAVMGDFLFVAGGevehASGRTCAVRTACRYDPRSNSWAEIAPMKNCR 284
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGG----YTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
Kelch smart00612
Kelch domain;
187-242 1.11e-05

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 42.55  E-value: 1.11e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 966940052   187 LYIIGGKKREVCkVKELRYFNPVDQEnaliaaianWSELAPMPVGRSHHCVAVMGD 242
Cdd:smart00612   2 IYVVGGFDGGQR-LKSVEVYDPETNK---------WTPLPSMPTPRSGHGVAVING 47
Kelch smart00612
Kelch domain;
296-327 2.11e-04

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 39.08  E-value: 2.11e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 966940052   296 LYAVGGRNElRQVLPTVERYCPKKNKWTFVQS 327
Cdd:smart00612   2 IYVVGGFDG-GQRLKSVEVYDPETNKWTPLPS 32
 
Name Accession Description Interval E-value
BACK_KLHL32_BKLHD5 cd18471
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also ...
 35-132 1.65e-63

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also termed BTB and kelch domain-containing protein 5 (BKLHD5), belongs to the KLHL family. Its function remains unclear. KLHL32 SNPs may be associated with body mass index in individuals of African ancestry.


Pssm-ID: 350546 [Multi-domain]  Cd Length: 98  Bit Score: 201.67  E-value: 1.65e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052  35 LNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSRPEDVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHN 114
Cdd:cd18471    1 LNSFNYLDLYKLADLFNLTLLEEAVVDFLVKHLSELLKSHPEEVLALPYRLLREVLKSDRLTSLSEEQIWQLAVRWLEHN 80

                         90
                 ....*....|....*...
gi 966940052 115 CHYQHMDELLQYIRFGLM 132
Cdd:cd18471   81 CRYQYMDELLQYVRFGLM 98
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
220-491 1.19e-39

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 144.91  E-value: 1.19e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052 220 ANWSELAPMPVGRSHHCVAVMGDFLFVAGGeveHASGRtcAVRTACRYDPRSNSWAEIAPMKNC-REHFVLGAMEEYLYA 298
Cdd:COG3055    1 ATWSSLPDLPTPRSEAAAALLDGKVYVAGG---LSGGS--ASNSFEVYDPATNTWSELAPLPGPpRHHAAAVAQDGKLYV 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052 299 VGGRNEL---RQVLPTVERYCPKKNKWTFVQSFDRSLSCHAGYVADGLLWISGGVTNTAqYQNRLMVYEPNQNKWISRSP 375
Cdd:COG3055   76 FGGFTGAnpsSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGG-NVAWVEVYDPATGTWTQLAP 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052 376 MLQRRVYHSMAAV-ERKLYVLGGndldynndrilvrhiDSYNIDTDQWTRCSfNLLTGQNESGVAVHNGRIYLVGGYSIW 454
Cdd:COG3055  155 LPTPRDHLAAAVLpDGKILVIGG---------------RNGSGFSNTWTTLA-PLPTARAGHAAAVLGGKILVFGGESGF 218

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 966940052 455 TNEplacIQVLDVSREGKEEVfygPTLPFASNGIAAC 491
Cdd:COG3055  219 SDE----VEAYDPATNTWTAL---GELPTPRHGHAAV 248
PHA03098 PHA03098
kelch-like protein; Provisional
 25-486 4.43e-30

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 123.34  E-value: 4.43e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052  25 VLSTCQTFM--ELNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSrpEDVLTLPYCLLQEVLKSDRLTSLSEEQ 102
Cdd:PHA03098  93 LINLCINYIikIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYND--PDFIYLSKNELIKILSDDKLNVSSEDV 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052 103 IWQLAVRWLEH--NCHYQHMDELLQYIRFGLMDVDTLHTVALSHPLVQASetaTALVNEALE---YHQSIYAQPVWQTRR 177
Cdd:PHA03098 171 VLEIIIKWLTSkkNNKYKDICLILKVLRITFLSEEGIKKLKRWKLRIKKK---KIVFNKRCIkiiYSKKYNLNKILPRSS 247

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052 178 TKPRFQSDTLYIIGGKKREVCKVKELRYFNPVDQENAliaaianwselapmpvgRSHHCVAVMGDFLFVAGGEVEhasgR 257
Cdd:PHA03098 248 TFGSIIYIHITMSIFTYNYITNYSPLSEINTIIDIHY-----------------VYCFGSVVLNNVIYFIGGMNK----N 306

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052 258 TCAVRTACRYDPRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRnELRQVLPTVERYCPKKNKWTFVQS--FDRSLSCH 335
Cdd:PHA03098 307 NLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGI-YNSISLNTVESWKPGESKWREEPPliFPRYNPCV 385

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052 336 AGYvaDGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVERKLYVLGGndLDYNNDRILVRHIDSY 415
Cdd:PHA03098 386 VNV--NNLIYVIGGISKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGG--ISYIDNIKVYNIVESY 461

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966940052 416 NIDTDQWTRCSFNLLTGQNESGVAVHNgRIYLVGGYSI--WTNEplacIQVLDVsrEGKEEVFYGPTLPFASN 486
Cdd:PHA03098 462 NPVTNKWTELSSLNFPRINASLCIFNN-KIYVVGGDKYeyYINE----IEVYDD--KTNTWTLFCKFPKVIGS 527
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
185-397 1.02e-26

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 109.48  E-value: 1.02e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052 185 DTLYIIGGkkrevckvkeLRYFNPVDQENALIAAIANWSELAPMP-VGRSHHCVAVMGDFLFVAGGEVEHASGRTcAVRT 263
Cdd:COG3055   23 GKVYVAGG----------LSGGSASNSFEVYDPATNTWSELAPLPgPPRHHAAAVAQDGKLYVFGGFTGANPSST-PLND 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052 264 ACRYDPRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVlPTVERYCPKKNKWTFVQSFDRSLSCHAGYVA-DG 342
Cdd:COG3055   92 VYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNV-AWVEVYDPATGTWTQLAPLPTPRDHLAAAVLpDG 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052 343 LLWISGGVTNTAQYQ---------------------NRLMV-------------YEPNQNKWISRSPMLQRRVYHSMAAV 388
Cdd:COG3055  171 KILVIGGRNGSGFSNtwttlaplptaraghaaavlgGKILVfggesgfsdeveaYDPATNTWTALGELPTPRHGHAAVLT 250


                 ....*....
gi 966940052 389 ERKLYVLGG 397
Cdd:COG3055  251 DGKVYVIGG 259
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 40-140 3.69e-25

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 99.34  E-value: 3.69e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052    40 YLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSrpEDVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHNC--HY 117
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSS--EEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPekRR 78

                           90       100
                   ....*....|....*....|...
gi 966940052   118 QHMDELLQYIRFGLMDVDTLHTV 140
Cdd:smart00875  79 EHLPELLEHVRLPLLSPDYLLEV 101
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 41-140 2.35e-19

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 82.98  E-value: 2.35e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052   41 LDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSrpEDVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHN--CHYQ 118
Cdd:pfam07707   2 LGIYRFADAYGCTELAEAALRFILQNFLEVAKS--EEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDveRRKK 79

                          90       100
                  ....*....|....*....|..
gi 966940052  119 HMDELLQYIRFGLMDVDTLHTV 140
Cdd:pfam07707  80 HLPELLSAVRLPLLSPQYLLNL 101
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
183-364 1.15e-16

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 80.20  E-value: 1.15e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052 183 QSDTLYIIGGKKREVCKVKELR---YFNPVDQEnaliaaianWSELAPMPVGRSHHCVAVMGDFLFVAGGEVEHAsgrtc 259
Cdd:COG3055   69 QDGKLYVFGGFTGANPSSTPLNdvyVYDPATNT---------WTKLAPMPTPRGGATALLLDGKIYVVGGWDDGG----- 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052 260 AVRTACRYDPRSNSWAEIAPMKNCREHFVLGAMEE-YLYAVGGRNE---------------------------------- 304
Cdd:COG3055  135 NVAWVEVYDPATGTWTQLAPLPTPRDHLAAAVLPDgKILVIGGRNGsgfsntwttlaplptaraghaaavlggkilvfgg 214

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052 305 LRQVLPTVERYCPKKNKWTFVQSFDRSLSCHAGYVADGLLWISGGVTNTAQYQNRLMVYE 364
Cdd:COG3055  215 ESGFSDEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGGETKPGVRTPLVTSAE 274
BACK_KBTBD3 cd18480
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 35-114 6.07e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350555 [Multi-domain]  Cd Length: 82  Bit Score: 61.57  E-value: 6.07e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052  35 LNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSrpEDVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHN 114
Cdd:cd18480    1 LDLSNCLQLLSFAESYGSTRLLDHALEFVMQHFSLLSQS--QEFLELNFEVLEKILEADELNVPDEEAVLKAVLRWTKHD 78
BACK_KLHL3 cd18513
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ...
 35-164 4.71e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.


Pssm-ID: 350588 [Multi-domain]  Cd Length: 130  Bit Score: 60.47  E-value: 4.71e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052  35 LNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSrpEDVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHN 114
Cdd:cd18513    1 LHPTNCLGIRAFADVHTCTELLQQANAYAEQHFPEVMLG--EEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWIKYD 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 966940052 115 --CHYQHMDELLQYIRFGLMDVDTLHTVALSHPLVQASETATALVNEALEYH 164
Cdd:cd18513   79 keARLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYH 130
BACK_KLHL9_13 cd18449
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 ...
 39-129 1.70e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 and KLHL13 (also termed BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.


Pssm-ID: 350524 [Multi-domain]  Cd Length: 95  Bit Score: 57.82  E-value: 1.70e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052  39 NYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSrpEDVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEH-NCHY 117
Cdd:cd18449    5 NCVEIGRIANTYHLTEVDKYVNDFILKNFPALLST--GDFVKLPFERLAFVLSSNSLKGCTELELFKAACRWLRHeDDRM 82

                         90
                 ....*....|..
gi 966940052 118 QHMDELLQYIRF 129
Cdd:cd18449   83 QFAAKLMENIRF 94
BACK_KLHL34 cd18473
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 34 (KLHL34); KLHL34 belongs ...
 46-137 7.13e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 34 (KLHL34); KLHL34 belongs to the KLHL family. Its function remains unclear. The methylation status of KLHL34 cg14232291 may be a predictive candidate of sensitivity to preoperative chemoradiation therapy.


Pssm-ID: 350548  Cd Length: 106  Bit Score: 56.28  E-value: 7.13e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052  46 LADLFNLTLLEKAVIDFLVKHLSELLKSRPEDV--LTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHN-CHYQHMDE 122
Cdd:cd18473   12 IAARFGLPDALKAAEKYIISNLWRLLASDADDAglLELNLESLQAVLEADDIPRVKESRLLTLVLEWLNQDeSRLAYANA 91

                         90
                 ....*....|....*
gi 966940052 123 LLQYIRFGLMDVDTL 137
Cdd:cd18473   92 LLSRIRYGLVPVEEL 106
BACK_KLHL12 cd18452
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ...
 35-164 1.43e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.


Pssm-ID: 350527 [Multi-domain]  Cd Length: 136  Bit Score: 56.25  E-value: 1.43e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052  35 LNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSrpEDVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHN 114
Cdd:cd18452    1 LDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQH--EEFMLLSQEEVEKLIKSDEIQVDSEEPVFEAVLNWVKHD 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 966940052 115 CH--YQHMDELLQYIRFGLMDVDTLHTVALSHPLVQASETATALVNEALEYH 164
Cdd:cd18452   79 KEerEDYLPELLQYVRLPLLSPRYITDVVDAEPLIRCSLECRDLVDEAKKFH 130
BACK_KLHL2_like cd18445
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...
 39-132 4.22e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.


Pssm-ID: 350520 [Multi-domain]  Cd Length: 114  Bit Score: 54.16  E-value: 4.22e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052  39 NYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSrpEDVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHN--CH 116
Cdd:cd18445    5 NCLGIRAFADLHSCTDLLKYAQTYTEQHFSEVVKG--EEFLLLSKEQVCELISSDDLTVPSEEKVFEAVMSWVNHDpeNR 82

                         90
                 ....*....|....*.
gi 966940052 117 YQHMDELLQYIRFGLM 132
Cdd:cd18445   83 KEHLAELLEHVRLPLL 98
BACK_KLHL2_Mayven cd18512
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ...
 35-164 4.87e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.


Pssm-ID: 350587 [Multi-domain]  Cd Length: 130  Bit Score: 54.65  E-value: 4.87e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052  35 LNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSrpEDVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHN 114
Cdd:cd18512    1 LHPTNCLGIRAFADMHACTELLNQANTYAEQHFSDVVLS--EEFLNLGIEQVCSLIASDKLTISSEEKVFEAVIAWVNHD 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 966940052 115 --CHYQHMDELLQYIRFGLMDVDTLHTVALSHPLVQASETATALVNEALEYH 164
Cdd:cd18512   79 keVRQEHMAHLMEHVRLPLLSREYLVQRVEEETLVKNSSACKDYLIEAMKYH 130
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 39-92 3.12e-08

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 49.97  E-value: 3.12e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 966940052  39 NYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSrpEDVLTLPYCLLQEVLKS 92
Cdd:cd14733    4 NCLGILELADLYNLEELKEKALKFILENFEEVSKS--EEFLELSVELLLELLSS 55
BACK_KLHL26 cd18465
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a ...
 41-132 4.09e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a kelch family protein encoded by gene klhl26, which is regulated by p53 via fuzzy tandem repeats.


Pssm-ID: 350540  Cd Length: 97  Bit Score: 51.06  E-value: 4.09e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052  41 LDLYRLADLFNLTLLEKAVIDFLVKHLSELlkSRPEDVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHN-CHYQH 119
Cdd:cd18465    7 LNIGQMATTFSLASLKESVDAFTFRHFLQI--AEEEDFLHLPLERLVFFLQSNKLKNCSEIDLFRAAIRWLQHDpSRRAS 84

                         90
                 ....*....|...
gi 966940052 120 MDELLQYIRFGLM 132
Cdd:cd18465   85 ASHVLCHIRFPLM 97
PLN02193 PLN02193
nitrile-specifier protein
 344-452 4.46e-08

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 55.35  E-value: 4.46e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052 344 LWISGGVTNTAQYqNRLMVYEPNQNKWISRSPMLQ---RRVYHSMAAVERKLYVLGGndldyNNDRILVRHIDSYNIDTD 420
Cdd:PLN02193 231 LYVFGGRDASRQY-NGFYSFDTTTNEWKLLTPVEEgptPRSFHSMAADEENVYVFGG-----VSATARLKTLDSYNIVDK 304

                         90       100       110
                 ....*....|....*....|....*....|....
gi 966940052 421 QWTRCS--FNLLTGQNESGVAVHNGRIYLVGGYS 452
Cdd:PLN02193 305 KWFHCStpGDSFSIRGGAGLEVVQGKVWVVYGFN 338
BACK_KLHL6 cd18446
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ...
 35-133 5.57e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.


Pssm-ID: 350521 [Multi-domain]  Cd Length: 108  Bit Score: 50.93  E-value: 5.57e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052  35 LNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSrpEDVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEH- 113
Cdd:cd18446    1 LHPENCVGILRLADAHSLESLKKQVQNYIIQNFSQVLNH--EEFLELPVDILCHILKSDDLYVTEEEQVFETVMRWVRYk 78

                         90       100
                 ....*....|....*....|.
gi 966940052 114 -NCHYQHMDELLQYIRFGLMD 133
Cdd:cd18446   79 eSERLPLLPRVLENVRLPLLD 99
BACK_KLHL33 cd18472
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs ...
 35-111 1.10e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs to the KLHL family. Its function remains unclear. KLHL33 SNPs may be associated with prostate cancer risk.


Pssm-ID: 350547 [Multi-domain]  Cd Length: 75  Bit Score: 48.92  E-value: 1.10e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966940052  35 LNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELlkSRPEDVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWL 111
Cdd:cd18472    1 LSPANCLELWAFADAATLPRLAAAARAFALKHFAEV--AASAAFLSLPLARLLELLRSDELEVAEEEAVFEAAVRWL 75
BACK_KLHL7 cd18447
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a ...
 34-131 1.27e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a BTB-Kelch protein that constitutes a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 cause autosomal-dominant retinitis pigmentosa.


Pssm-ID: 350522 [Multi-domain]  Cd Length: 98  Bit Score: 49.66  E-value: 1.27e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052  34 ELNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSrpEDVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEH 113
Cdd:cd18447    1 QVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKT--DEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKY 78

                         90       100
                 ....*....|....*....|
gi 966940052 114 N-CHYQH-MDELLQYIRFGL 131
Cdd:cd18447   79 DePNRQPyMVDILAKVRFPL 98
BACK_KLHL18 cd18457
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ...
 35-132 1.88e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A.


Pssm-ID: 350532 [Multi-domain]  Cd Length: 107  Bit Score: 49.23  E-value: 1.88e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052  35 LNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSrpEDVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHN 114
Cdd:cd18457    1 LHPNNCLGIRQFAETMMCSSLVDAANKYIQQHFIEVSKS--EEFLALSKEEVLEILSRDELNVKSEEQVFEAALAWVKYD 78

                         90       100
                 ....*....|....*....|..
gi 966940052 115 ----CHYqhMDELLQYIRFGLM 132
Cdd:cd18457   79 renrEEY--LPELLSKVRLPLL 98
Kelch_6 pfam13964
Kelch motif;
232-284 9.04e-07

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 45.79  E-value: 9.04e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 966940052  232 RSHHCVAVMGDFLFVAGGevehASGRTCAVRTACRYDPRSNSWAEIAPMKNCR 284
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGG----YTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
BACK_KLHL22 cd18461
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a ...
 39-133 1.25e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of Polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation.


Pssm-ID: 350536  Cd Length: 104  Bit Score: 47.06  E-value: 1.25e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052  39 NYLDLYRLADLFNLTLLEKAVIDFLVKHLSELlkSRPEDVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWlehncHY- 117
Cdd:cd18461    5 NILDVYKLADLFHLTHLSEQLDSYILKNFPTF--SRTETYRQLPLEKVYSLLSSNRLEVDSENEVYEGALLY-----HYt 77

                         90       100
                 ....*....|....*....|....*..
gi 966940052 118 -----------QHMDELLQYIRFGLMD 133
Cdd:cd18461   78 peqvekdqvslQEPPKLLEAVRFPLME 104
BACK_KLHL21 cd18460
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a ...
 39-128 1.26e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively.


Pssm-ID: 350535 [Multi-domain]  Cd Length: 101  Bit Score: 46.72  E-value: 1.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052  39 NYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSrpEDVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRW----LEHN 114
Cdd:cd18460    5 NCLEMQDFAEAFACRGLAEAAKRFILRHIVELAKG--EQFERLPLKRLLEYLSDDGLCVDKEETAYQIALRWvkadPKHR 82

                         90
                 ....*....|....
gi 966940052 115 CHyqHMDELLQYIR 128
Cdd:cd18460   83 QH--FWPELLQHVR 94
BACK_KEL_like cd18508
BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch ...
 39-114 1.35e-06

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch protein (KEL) and similar proteins; KEL, also termed kelch short protein, is a component of ring canals that regulates the flow of cytoplasm between cells. It binds actin and may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis.


Pssm-ID: 350583 [Multi-domain]  Cd Length: 77  Bit Score: 46.25  E-value: 1.35e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966940052  39 NYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSrpEDVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHN 114
Cdd:cd18508    4 NCLGIHEFADAHSCVELEEAAQNYIYQHFNEVIQG--EEFLSLDHESLTELISSDRLNVPSEERVYEAAVAWLKHD 77
BACK_KLHL5 cd18511
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares ...
 34-132 2.71e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. It is abundantly expressed in ovary, adrenal gland, and thymus.


Pssm-ID: 350586 [Multi-domain]  Cd Length: 106  Bit Score: 46.21  E-value: 2.71e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052  34 ELNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLksRPEDVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEH 113
Cdd:cd18511    1 QLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVI--RNQEFLLLPASEIAKLLASDDMNIPNEETILNALLSWVRH 78

                         90       100
                 ....*....|....*....|.
gi 966940052 114 NCHYQHMD--ELLQYIRFGLM 132
Cdd:cd18511   79 DVEQRRKDlsKLLAYIRLPLL 99
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 379-426 3.83e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 43.75  E-value: 3.83e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 966940052  379 RRVYHSMAAVERKLYVLGGndldYNNDRILvRHIDSYNIDTDQWTRCS 426
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGG----FDGNQSL-NSVEVYDPETNTWSKLP 43
Kelch smart00612
Kelch domain;
187-242 1.11e-05

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 42.55  E-value: 1.11e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 966940052   187 LYIIGGKKREVCkVKELRYFNPVDQEnaliaaianWSELAPMPVGRSHHCVAVMGD 242
Cdd:smart00612   2 IYVVGGFDGGQR-LKSVEVYDPETNK---------WTPLPSMPTPRSGHGVAVING 47
BACK_calicin cd18503
BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal ...
 35-114 1.12e-05

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa.


Pssm-ID: 350578 [Multi-domain]  Cd Length: 78  Bit Score: 43.49  E-value: 1.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052  35 LNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELlkSRPEDVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHN 114
Cdd:cd18503    1 LDRDNCLTALCLATTAGLKDLSDEIYDYIRDNFFDV--SGTREFLQCPYDIFSRLLKDENLHVNNEDQVLLALLNWTEHN 78
BACK_KLHL15 cd18454
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a ...
 39-132 1.75e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for Cullin3 E3 ubiquitin-protein ligase complex that target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation.


Pssm-ID: 350529  Cd Length: 108  Bit Score: 43.73  E-value: 1.75e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052  39 NYLDLYRLADLFNLTL--LEKAVIDFLVKHLSELLkSRPEDVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHN-C 115
Cdd:cd18454    5 NCAEIMRLLDDFSVNIegVREKLDSFLLENFVPLM-SRPDFLSYLSFEKLMSYLDNDHLSRFPEIELYEAVQAWLRHDrR 83

                         90
                 ....*....|....*..
gi 966940052 116 HYQHMDELLQYIRFGLM 132
Cdd:cd18454   84 RWRHTDTIIQNIRFCLM 100
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 284-327 1.86e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 41.83  E-value: 1.86e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 966940052  284 REHFVLGAMEEYLYAVGGRNElRQVLPTVERYCPKKNKWTFVQS 327
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDG-NQSLNSVEVYDPETNTWSKLPS 44
BACK_KLHL8 cd18448
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...
 39-129 2.62e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.


Pssm-ID: 350523 [Multi-domain]  Cd Length: 97  Bit Score: 43.06  E-value: 2.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052  39 NYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSrpEDVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHNC--H 116
Cdd:cd18448    6 NCLGVRTFAEQHNRVDLMKMADKYACDHFNEVVEC--EEFVSISAQHLEKLISSSDLNVESESQVYEAVMKWVKHDPqhR 83

                         90
                 ....*....|...
gi 966940052 117 YQHMDELLQYIRF 129
Cdd:cd18448   84 KRHLDDLLSQVRL 96
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 232-281 3.74e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 41.06  E-value: 3.74e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 966940052  232 RSHHCVAVMGDFLFVAGGevehaSGRTCAVRTACRYDPRSNSWAEIAPMK 281
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGG-----FDGNQSLNSVEVYDPETNTWSKLPSMP 46
BACK_BTBD9 cd14822
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); ...
 35-137 5.60e-05

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation.


Pssm-ID: 350518 [Multi-domain]  Cd Length: 101  Bit Score: 42.21  E-value: 5.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052  35 LNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSrpEDVLTLPYCLLQEVLKSDRLTSlSEEQIWQLAVRWLEHN 114
Cdd:cd14822    1 LNIRNVCLIYDVASLYSLDDLCQTCCQFMDRNAQEVLSS--EGFLTLSKSALKELLSRDSFCA-PEVDIFNAVRRWCEHN 77

                         90       100
                 ....*....|....*....|....
gi 966940052 115 C-HYQHMDELLQYIRFGLMDVDTL 137
Cdd:cd14822   78 PdSKEDAKEILEAVRLPLMSLTEL 101
BACK_KBTBD2 cd18479
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 35-128 6.32e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulating the insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation.


Pssm-ID: 350554 [Multi-domain]  Cd Length: 96  Bit Score: 41.97  E-value: 6.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052  35 LNSFNYLDLYRLADLFNLTLLeKAVIDFLVKHLSELLkSRPEDVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHN 114
Cdd:cd18479    1 INAENCVRLLSFADLFSCEEL-KQSAKRMVEHKFTAV-YHQEAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYN 78

                         90
                 ....*....|....*.
gi 966940052 115 C--HYQHMDELLQYIR 128
Cdd:cd18479   79 TesRSQYLSSVLSQIR 94
BACK_KLHL17 cd18456
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also ...
 35-135 6.95e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also termed actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GluR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in the actin-based neuronal function.


Pssm-ID: 350531 [Multi-domain]  Cd Length: 102  Bit Score: 41.91  E-value: 6.95e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052  35 LNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSrpEDVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHN 114
Cdd:cd18456    1 LDPSNCLGIRGFADTHSCSDLLKSAHKYVLQHFVEVSKT--EEFMLLPLKQVLDLISSDSLNVPSEEEVYRAVLSWVKHD 78

                         90       100
                 ....*....|....*....|...
gi 966940052 115 C--HYQHMDELLQYIRFGLMDVD 135
Cdd:cd18456   79 VdgRRQHVPRLMKCVRLPLLSRD 101
BACK_KLHL4 cd18510
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares ...
 34-132 7.22e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350585 [Multi-domain]  Cd Length: 106  Bit Score: 42.21  E-value: 7.22e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052  34 ELNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSrpEDVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEH 113
Cdd:cd18510    1 QLHPSNCLGIRSFGDAQGCTELLKVAHSYTMEHFLEVIKN--QEFLLLPASEIVKLLASDDINVPDEETIFQALMMWVRH 78

                         90       100
                 ....*....|....*....|.
gi 966940052 114 N--CHYQHMDELLQYIRFGLM 132
Cdd:cd18510   79 DlqNRQKDLGMLLSYIRLPLL 99
BACK_KLHL10 cd18450
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be ...
 35-114 8.12e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.


Pssm-ID: 350525 [Multi-domain]  Cd Length: 80  Bit Score: 41.06  E-value: 8.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052  35 LNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKsRPEDVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHN 114
Cdd:cd18450    1 LTPENCIGIRKFARYYFCPELERKAYRYILRNFEEVAK-DSEEFLELSCEELEDIIEDDELNVKEEEVVFEAIVKWIDHD 79
PHA02713 PHA02713
hypothetical protein; Provisional
 276-419 8.85e-05

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 45.00  E-value: 8.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052 276 EIAPMKNCREHFVLGAMEEYLYAVGGRNElRQVLPTVERYCPKKNKWTFVQSFDRSLSCHAGYVADGLLWISGGVTNTAQ 355
Cdd:PHA02713 334 ELPPMIKNRCRFSLAVIDDTIYAIGGQNG-TNVERTIECYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGGRTEHID 412

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052 356 Y-----------------QNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVERKLYVLggndLDYNNDRILVRHIDSYNID 418
Cdd:PHA02713 413 YtsvhhmnsidmeedthsSNKVIRYDTVNNIWETLPNFWTGTIRPGVVSHKDDIYVV----CDIKDEKNVKTCIFRYNTN 488


                 .
gi 966940052 419 T 419
Cdd:PHA02713 489 T 489
BACK_KLHL20 cd18459
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also ...
 76-132 1.46e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also termed Kelch-like ECT2-interacting protein (KLEIP), or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis.


Pssm-ID: 350534 [Multi-domain]  Cd Length: 100  Bit Score: 40.88  E-value: 1.46e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 966940052  76 EDVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHNC--HYQHMDELLQYIRFGLM 132
Cdd:cd18459   41 EEFMLLPVNQLIDIISSDELNVRSEEQVFNAVMAWVKYNIqeRRPHLPQVLQHVRLPLL 99
BACK_KLHL16_gigaxonin cd18455
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...
 47-124 1.51e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.


Pssm-ID: 350530 [Multi-domain]  Cd Length: 97  Bit Score: 40.76  E-value: 1.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052  47 ADLFNLTLLEKAVIDFLVKHLSELlkSRPEDVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHNCHYQ--HMDELL 124
Cdd:cd18455   12 AERFSCPHVHYVATEYLETHFRDV--SSTEEFLELSPEKLKELLSRDKLNVGNEEYIFEAVLRWVRHDPEERkvHLKDLM 89
PRK14131 PRK14131
N-acetylneuraminate epimerase;
385-452 1.53e-04

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 44.24  E-value: 1.53e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966940052 385 MAAVERKLYVLGGNDlDYNNDR--ILVRHIDSYNIDTDQW----TRCSFNLLTGqneSGVAVHNGRIYLVGGYS 452
Cdd:PRK14131  80 AAFIDGKLYVFGGIG-KTNSEGspQVFDDVYKYDPKTNSWqkldTRSPVGLAGH---VAVSLHNGKAYITGGVN 149
BACK_KLHL35 cd18474
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ...
 39-113 2.00e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.


Pssm-ID: 350549 [Multi-domain]  Cd Length: 79  Bit Score: 40.18  E-value: 2.00e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966940052  39 NYLDLYRLADLFNLTLLEKAVIDFLVKHLSELlkSRPEDVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEH 113
Cdd:cd18474    5 NCLALLAAADALHCAPLQEHCIRVLLRDFAQA--ARHPSFLKLELQLVLELLADDSLAVRSEEVVLEAALRWVDA 77
BACK_KLHL37_ENC1 cd18515
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also ...
 73-132 2.08e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350590 [Multi-domain]  Cd Length: 98  Bit Score: 40.34  E-value: 2.08e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966940052  73 SRPEDVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEH--NCHYQHMDELLQYIRFGLM 132
Cdd:cd18515   36 CKTEDFLQLPKDMVVQLLSSEELETEDERLVYEAAINWVNYdlKKRHCYLSELLQTVRLALL 97
Kelch smart00612
Kelch domain;
296-327 2.11e-04

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 39.08  E-value: 2.11e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 966940052   296 LYAVGGRNElRQVLPTVERYCPKKNKWTFVQS 327
Cdd:smart00612   2 IYVVGGFDG-GQRLKSVEVYDPETNKWTPLPS 32
Kelch smart00612
Kelch domain;
391-443 2.11e-04

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 39.08  E-value: 2.11e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 966940052   391 KLYVLGGndldYNNDRILvRHIDSYNIDTDQWTRCSfNLLTGQNESGVAVHNG 443
Cdd:smart00612   1 KIYVVGG----FDGGQRL-KSVEVYDPETNKWTPLP-SMPTPRSGHGVAVING 47
BACK_KLHL38 cd18476
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs ...
 35-128 3.07e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs to the KLHL family. Its function remains unclear. The klhl38 gene has recently been identified as a possible diapause (a temporary arrest of development during early ontogeny) gene, as it is significantly up-regulated during diapause. It may also be involved in chicken preadipocyte differentiation.


Pssm-ID: 350551 [Multi-domain]  Cd Length: 99  Bit Score: 40.11  E-value: 3.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052  35 LNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSrpEDVLTLPYCLLQEVLKSDRLTSlSEEQIWQLAVRWLEHN 114
Cdd:cd18476    1 LTPSNCLSMIRLSEILNCETLKKKAKDMALQCFPDVAAS--EDLKELCASELLDYLGDDELCG-EEEQVFETLMVWIRHD 77

                         90
                 ....*....|....*.
gi 966940052 115 CHYQ--HMDELLQYIR 128
Cdd:cd18476   78 PKARkgYIHDLFKKVR 93
BACK_ABTB1_BPOZ cd18497
BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing ...
 35-73 3.16e-04

BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein, or Bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homologue (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes.


Pssm-ID: 350572  Cd Length: 72  Bit Score: 39.07  E-value: 3.16e-04
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 966940052  35 LNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKS 73
Cdd:cd18497    1 LDEDNVIDVLRTARLFNLPRLEDQCTEFMAKNLEELVDD 39
BACK_KLHL19_KEAP1 cd18458
BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); ...
 55-124 4.07e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also termed cytosolic inhibitor of Nrf2 (INrf2), or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.


Pssm-ID: 350533 [Multi-domain]  Cd Length: 91  Bit Score: 39.58  E-value: 4.07e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966940052  55 LEKAVIDFLVKHLSELLKSrpEDVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHNC--HYQHMDELL 124
Cdd:cd18458   22 LHKKAREYIYMHFSEVSQS--EEFFNLSPCQLVALISRDELNVRCESEVYNAVIRWVKYDEenRRQYLEALL 91
BACK_KLHL29_KBTBD9 cd18468
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also ...
 39-129 6.97e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers.


Pssm-ID: 350543 [Multi-domain]  Cd Length: 102  Bit Score: 38.93  E-value: 6.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052  39 NYLDLYRLADLFNLTLLEKAVIDFLVKHLSELlkSRPEDVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHN--CH 116
Cdd:cd18468    4 NCLGIWALAEALQCTELHNMAKAYALQNFPDV--ARQEEILSISKDDIVEYLSHDSLNTKAEELVFETAIKWLKKDpkNR 81

                         90
                 ....*....|...
gi 966940052 117 YQHMDELLQYIRF 129
Cdd:cd18468   82 KQHIAELLAVVRL 94
BACK_BTBD17 cd18493
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); ...
 44-111 7.64e-04

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression.


Pssm-ID: 350568  Cd Length: 74  Bit Score: 38.33  E-value: 7.64e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966940052  44 YRLADLFNLTLLEKAVIDFLVKHLSELLKSrpEDVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWL 111
Cdd:cd18493    9 LQYAKMCGHKELAEACLEFIAWNFEKVLKS--PDWLNLDLDLLVSLLQSSDLVVEDEYTLFQAVEKWL 74
BACK_KBTBD6_7 cd18482
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing ...
 41-129 9.34e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing proteins, KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling.


Pssm-ID: 350557 [Multi-domain]  Cd Length: 99  Bit Score: 38.64  E-value: 9.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052  41 LDLY------RLADLFNLTLLEKAVIDFLVKHLSELLKsRPEDVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHN 114
Cdd:cd18482    1 LDLSncagilKFADAFDNRELKSKALAFIARNFQQLLA-KEEELCELSLAQLKEVLMLDSLDVDSERKVCSVAVQWIEAN 79

                         90
                 ....*....|....*..
gi 966940052 115 CHYQHMD--ELLQYIRF 129
Cdd:cd18482   80 LKERAASaaEVLKCVRW 96
PRK14131 PRK14131
N-acetylneuraminate epimerase;
271-397 1.01e-03

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 41.54  E-value: 1.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052 271 SNSWAEIAPMKNC-REHFVLGAMEEYLYAVGG---RNE--LRQVLPTVERYCPKKNKWTFVQSFD-RSLSCHAGYVADG- 342
Cdd:PRK14131  61 SKGWTKIAAFPGGpREQAVAAFIDGKLYVFGGigkTNSegSPQVFDDVYKYDPKTNSWQKLDTRSpVGLAGHVAVSLHNg 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052 343 LLWISGGV-----------TNTA----------------------QYQNRLMVYEPNQNKWIS--RSPMLQrRVYHSMAA 387
Cdd:PRK14131 141 KAYITGGVnknifdgyfedLAAAgkdktpkdkindayfdkkpedyFFNKEVLSYDPSTNQWKNagESPFLG-TAGSAVVI 219

                        170
                 ....*....|
gi 966940052 388 VERKLYVLGG 397
Cdd:PRK14131 220 KGNKLWLING 229
Kelch smart00612
Kelch domain;
343-389 1.22e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 36.77  E-value: 1.22e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 966940052   343 LLWISGGvTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVE 389
Cdd:smart00612   1 KIYVVGG-FDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVIN 46
BACK_KLHL11 cd18451
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a ...
 35-114 1.70e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.


Pssm-ID: 350526 [Multi-domain]  Cd Length: 88  Bit Score: 37.63  E-value: 1.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052  35 LNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSrpEDVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHN 114
Cdd:cd18451    1 LNLSNCVAIHSLAHMYSLDQLALKAADMIRRNFHKVIQD--EEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVLKWVQRN 78
BACK_KLHL42_KLHDC5 cd18478
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also ...
 39-91 1.99e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9), or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. KLHL42 is involved in microtubule dynamics throughout mitosis.


Pssm-ID: 350553  Cd Length: 103  Bit Score: 37.83  E-value: 1.99e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 966940052  39 NYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKsRPEDvLTLPYCLLQEVLK 91
Cdd:cd18478    5 NCLELYRLAQVYGLRDLAEACLKFMATHYHPMLR-RPEF-RPLPSSLKQQLRE 55
Kelch smart00612
Kelch domain;
244-287 2.63e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 36.00  E-value: 2.63e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 966940052   244 LFVAGGeveHASGRTCavRTACRYDPRSNSWAEIAPMKNCREHF 287
Cdd:smart00612   2 IYVVGG---FDGGQRL--KSVEVYDPETNKWTPLPSMPTPRSGH 40
BACK_KLHL40_KBTBD5 cd18516
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also ...
 39-132 3.31e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5, or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy.


Pssm-ID: 350591 [Multi-domain]  Cd Length: 99  Bit Score: 37.04  E-value: 3.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052  39 NYLDLYRLADLFNLTLLEKAVIDFLVKHLSelLKSRPEDVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHNCHYQ 118
Cdd:cd18516    5 NCLAIFRLGLLLDCPRLAVAARDFICDRFQ--LIARDEDFLQLSPDELIAIISSDSLNVEKEEDVFEAVMKWVGKDQEER 82

                         90
                 ....*....|....*.
gi 966940052 119 HMD--ELLQYIRFGLM 132
Cdd:cd18516   83 TKAlpVLLESIRFRLM 98
BACK_KLHL40_like cd18477
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The ...
 39-132 3.65e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells.


Pssm-ID: 350552 [Multi-domain]  Cd Length: 99  Bit Score: 37.13  E-value: 3.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052  39 NYLDLYRLADLFNLTLLEKAVIDFLVKHLSELlkSRPEDVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHN--CH 116
Cdd:cd18477    5 NCLAIFRLGLLLDCPRLAVSARDFICAHFTLV--AKDEDFLGLSADELIAIISSDGLNVEKEEAVFEAVMKWVREAkeNR 82

                         90
                 ....*....|....*.
gi 966940052 117 YQHMDELLQYIRFGLM 132
Cdd:cd18477   83 QKALPTVFESIRFRLL 98
BACK_KBTBD12 cd18485
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 62-134 3.80e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also termed Kelch domain-containing protein 6 (KLHDC6), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350560 [Multi-domain]  Cd Length: 100  Bit Score: 37.01  E-value: 3.80e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966940052  62 FLVKHLSELlkSRPEDVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHN--CHYQHMDELLQYIRFGLMDV 134
Cdd:cd18485   28 YLYQHFTEV--CLHEEVLEIEAHQLLTLIKSDDLNVSREESILDLVLRWVNHNrkSRVQHLVELLKQVRLELVSP 100
BACK_KLHL36 cd18475
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act ...
 39-132 3.87e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.


Pssm-ID: 350550  Cd Length: 100  Bit Score: 37.13  E-value: 3.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052  39 NYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSRP--EDVLTLPYCLLqevLKSDRLTSLSEEQIWQLAVRWLEHNCH 116
Cdd:cd18475    5 NYLYLQELASIYSLERLDSFIDSFILQNFGTLSFTPDflQNVSMQKLCQY---LSSNQVQHECEHDLLQAALQWLTQSPE 81

                         90
                 ....*....|....*..
gi 966940052 117 YQ-HMDELLQYIRFGLM 132
Cdd:cd18475   82 REnEAYQVLSNIHFPLI 98
Kelch_3 pfam13415
Galactose oxidase, central domain;
341-388 3.88e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 35.34  E-value: 3.88e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 966940052  341 DGLLWISGG-VTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAV 388
Cdd:pfam13415   1 GDKLYIFGGlGFDGQTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSATYI 49
BACK_NS1BP_IVNS1ABP cd18502
BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); ...
 35-126 4.48e-03

BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); NS1-BP, also called NS1-binding protein, or Aryl hydrocarbon receptor-associated protein 3, or IVNS1ABP, is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control.


Pssm-ID: 350577  Cd Length: 99  Bit Score: 36.83  E-value: 4.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052  35 LNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSrpEDVLTLPyCLLQEVLKSDR--LTSLSEEQIWQLAVRWLE 112
Cdd:cd18502    1 LTPENCIGIRSFAGRMNDSELLQKVDSYIQENIEEVAES--KEFLKLP-RLQIEVILESNqeLESINERKLCQLVLEWVQ 77

                         90
                 ....*....|....*.
gi 966940052 113 HNCHYQ--HMDELLQY 126
Cdd:cd18502   78 RSIEEGglDLDDLTEK 93
BACK_KLHL25_like cd18464
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The ...
 76-132 5.10e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The family includes KLHL25 and KLHL37. KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350539 [Multi-domain]  Cd Length: 98  Bit Score: 36.71  E-value: 5.10e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 966940052  76 EDVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHNC--HYQHMDELLQYIRFGLM 132
Cdd:cd18464   39 EDFLSLPKDKLLELVSSEELEVEDERLVYEAVIGWIRYDLprRHEVLPELLRSVRLALL 97
Kelch_4 pfam13418
Galactose oxidase, central domain;
379-426 5.14e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 35.28  E-value: 5.14e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 966940052  379 RRVYHSMAAVER-KLYVLGGndldYNNDRILVRHIDSYNIDTDQWTRCS 426
Cdd:pfam13418   1 PRAYHTSTSIPDdTIYLFGG----EGEDGTLLSDLWVFDLSTNEWTRLG 45
Kelch_6 pfam13964
Kelch motif;
380-426 6.31e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 35.00  E-value: 6.31e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 966940052  380 RVYHSMAAVERKLYVLGGndldYNNDRILVRHIDSYNIDTDQWTRCS 426
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGG----YTNASPALNKLEVYNPLTKSWEELP 44
BACK_KLHL31_KBTBD1 cd18470
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also ...
 46-130 6.70e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also termed BTB and kelch domain-containing protein 6, or Kelch repeat and BTB domain-containing protein 1, or Kelch-like protein KLHL, is a transcriptional repressor in MAPK/JNK signaling pathway that regulates cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).


Pssm-ID: 350545  Cd Length: 98  Bit Score: 36.39  E-value: 6.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052  46 LADLFNLTLLEKAVIDFLVKHLSELlkSRPEDVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHNC-HYQHMDELL 124
Cdd:cd18470   12 IAETYGLKNTKEAAQKFIRDNFIEF--SETDQFLKLTFEQINEFLIDDDLQLPSEITAFQIAMKWLDFDQkRVKYAADLL 89


                 ....*.
gi 966940052 125 QYIRFG 130
Cdd:cd18470   90 SNIRFG 95
BACK_KLHL1_like cd18444
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; ...
 39-132 6.86e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels.


Pssm-ID: 350519 [Multi-domain]  Cd Length: 106  Bit Score: 36.54  E-value: 6.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966940052  39 NYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSrpEDVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHNC--H 116
Cdd:cd18444    6 NCLGIRSFADAQGCTDLLKVAHNYTMEHFMEVIQN--QEFLLLPAEEVAKLLASDDLNVPSEETIFHALLLWVKHDLpeR 83

                         90
                 ....*....|....*.
gi 966940052 117 YQHMDELLQYIRFGLM 132
Cdd:cd18444   84 KKHLAKLLALIRLPLL 99
Kelch_6 pfam13964
Kelch motif;
339-380 9.01e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 34.62  E-value: 9.01e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 966940052  339 VADGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRR 380
Cdd:pfam13964   9 SVGGYIYVFGGYTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH