calcipressin-2 isoform X1 [Macaca mulatta]
Protein Classification
calcipressin( domain architecture ID 10522024)
calcipressin functions as a calcineurin inhibitor
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||
| Calcipressin | pfam04847 | Calcipressin; Calcipressin is also known as calcineurin-binding protein, since it inhibits ... |
68-236 | 2.83e-83 | ||||
Calcipressin; Calcipressin is also known as calcineurin-binding protein, since it inhibits calcineurin-mediated transcriptional modulation by binding to calcineurin's catalytic domain. : Pssm-ID: 282674 Cd Length: 183 Bit Score: 246.33 E-value: 2.83e-83
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| Name | Accession | Description | Interval | E-value | ||||
| Calcipressin | pfam04847 | Calcipressin; Calcipressin is also known as calcineurin-binding protein, since it inhibits ... |
68-236 | 2.83e-83 | ||||
Calcipressin; Calcipressin is also known as calcineurin-binding protein, since it inhibits calcineurin-mediated transcriptional modulation by binding to calcineurin's catalytic domain. Pssm-ID: 282674 Cd Length: 183 Bit Score: 246.33 E-value: 2.83e-83
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| RRM_RCAN2 | cd12709 | RNA recognition motif (RRM) found in vertebrate regulator of calcineurin 2 (RCAN2); This ... |
57-133 | 1.47e-53 | ||||
RNA recognition motif (RRM) found in vertebrate regulator of calcineurin 2 (RCAN2); This subgroup corresponds to the RRM of RCAN2, also termed calcipressin-2, or Down syndrome candidate region 1-like 1 (DSCR1L1), or myocyte-enriched calcineurin-interacting protein 2 (MCIP2), or thyroid hormone-responsive protein ZAKI-4, encoded by a novel thyroid hormone-responsive gene ZAKI-4 that is abundantly expressed in human brain, heart and muscles. RCAN2 binds to the catalytic subunit of Ca2+/calmodulin-dependent phosphatase calcineurin (also termed PP2B or PP3C), calcineurin A, and inhibits its phosphatase activity through its C-terminal region. RCAN2 consists of an N-terminal RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain), a highly conserved SP repeat domain containing the phosphorylation site by GSK-3, a well-known PxIxIT motif responsible for docking many substrates to calcineurin, and an unrecognized C-terminal TxxP motif of unknown function. Pssm-ID: 410108 Cd Length: 77 Bit Score: 167.04 E-value: 1.47e-53
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| Name | Accession | Description | Interval | E-value | ||||
| Calcipressin | pfam04847 | Calcipressin; Calcipressin is also known as calcineurin-binding protein, since it inhibits ... |
68-236 | 2.83e-83 | ||||
Calcipressin; Calcipressin is also known as calcineurin-binding protein, since it inhibits calcineurin-mediated transcriptional modulation by binding to calcineurin's catalytic domain. Pssm-ID: 282674 Cd Length: 183 Bit Score: 246.33 E-value: 2.83e-83
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| RRM_RCAN2 | cd12709 | RNA recognition motif (RRM) found in vertebrate regulator of calcineurin 2 (RCAN2); This ... |
57-133 | 1.47e-53 | ||||
RNA recognition motif (RRM) found in vertebrate regulator of calcineurin 2 (RCAN2); This subgroup corresponds to the RRM of RCAN2, also termed calcipressin-2, or Down syndrome candidate region 1-like 1 (DSCR1L1), or myocyte-enriched calcineurin-interacting protein 2 (MCIP2), or thyroid hormone-responsive protein ZAKI-4, encoded by a novel thyroid hormone-responsive gene ZAKI-4 that is abundantly expressed in human brain, heart and muscles. RCAN2 binds to the catalytic subunit of Ca2+/calmodulin-dependent phosphatase calcineurin (also termed PP2B or PP3C), calcineurin A, and inhibits its phosphatase activity through its C-terminal region. RCAN2 consists of an N-terminal RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain), a highly conserved SP repeat domain containing the phosphorylation site by GSK-3, a well-known PxIxIT motif responsible for docking many substrates to calcineurin, and an unrecognized C-terminal TxxP motif of unknown function. Pssm-ID: 410108 Cd Length: 77 Bit Score: 167.04 E-value: 1.47e-53
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| RRM_RCAN3 | cd12710 | RNA recognition motif (RRM) found in vertebrate regulator of calcineurin 3 (RCAN3); This ... |
58-133 | 8.89e-44 | ||||
RNA recognition motif (RRM) found in vertebrate regulator of calcineurin 3 (RCAN3); This subgroup corresponds to the RRM of RCAN3, also termed calcipressin-3, or Down syndrome candidate region 1-like protein 2 (DSCR1L2), or myocyte-enriched calcineurin-interacting protein 3 (MCIP3), encoded by a ubiquitously expressed DSCR1L2 gene. Overexpressed RCAN3 binds and inhibits the Ca2+/calmodulin-dependent phosphatase calcineurin (also termed PP2B or PP3C), and further down-regulates nuclear factor of activated T cells (NFAT)-dependent cytokine gene expression in activated human Jurkat T cells. Moreover, RCAN3 interacts with cardiac troponin I (TNNI3), a heart-specific inhibitory subunit of the troponin complex, and may play a role in cardiac contraction. RCAN3 consists of an N-terminal RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain), a highly conserved SP repeat domain containing the phosphorylation site by GSK-3, a well-known PxIxIT motif responsible for docking many substrates to calcineurin, and an unrecognized C-terminal TxxP motif of unknown function. Pssm-ID: 410109 Cd Length: 77 Bit Score: 142.38 E-value: 8.89e-44
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| RRM_RCAN1 | cd12708 | RNA recognition motif (RRM) found in vertebrate regulator of calcineurin 1 (RCAN1); This ... |
58-153 | 6.72e-38 | ||||
RNA recognition motif (RRM) found in vertebrate regulator of calcineurin 1 (RCAN1); This subgroup corresponds to the RRM of RCAN1, also termed calcipressin-1, or Adapt78, or Down syndrome critical region protein 1, or myocyte-enriched calcineurin-interacting protein 1 (MCIP1), encoded by the Down syndrome critical region 1 (DSCR1) gene that is abundantly expressed in human brain, heart and muscles. Overexpressed RCAN1 functions as an inhibitor of the Ca2+/calmodulin-dependent phosphatase calcineurin (also termed PP2B or PP3C), and is associated with Alzheimer's disease (AD) and Down syndrome (DS). RCAN1 can be phosphorylated by several kinases such as big MAP kinase 1 (BMK1), glycogen synthase kinase-3 (GSK-3), NF-kappaB inducing kinase (NIK), and protein kinase A (PKA). The phosphorylation of RCAN1 can positively or negatively regulate calcineurin-mediated gene transcription, and also affect its protein stability in the ubiquitin-proteasome pathway. RCAN1 consists of an N-terminal RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain), a highly conserved SP repeat domain containing the phosphorylation site by GSK-3, a well-known PxIxIT motif responsible for docking many substrates to calcineurin, and an unrecognized C-terminal TxxP motif of unknown function. Pssm-ID: 410107 Cd Length: 93 Bit Score: 127.65 E-value: 6.72e-38
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| RRM_RCAN_like | cd12434 | RNA recognition motif (RRM) found in regulators of calcineurin (RCANs) and similar proteins; ... |
59-133 | 5.91e-34 | ||||
RNA recognition motif (RRM) found in regulators of calcineurin (RCANs) and similar proteins; This subfamily corresponds to the RRM of RCANs, a novel family of calcineurin regulators that are key factors contributing to Down syndrome in humans. They can stimulate and inhibit the Ca2+/calmodulin-dependent phosphatase calcineurin (also termed PP2B or PP3C) signaling in vivo through direct interactions with its catalytic subunit. Overexpressed RCANs may bind and inhibit calcineurin. In contrast, low levels of phosphorylated RCANs may stimulate the calcineurin signaling. RCANs are characterized by harboring a central short, unique serine-proline motif containing FLIISPPxSPP box, which is strongly conserved from yeast to human but is absent in bacteria. They consist of an N-terminal RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain), a highly conserved SP repeat domain containing the phosphorylation site by GSK-3, a well-known PxIxIT motif responsible for docking many substrates to calcineurin, and an unrecognized C-terminal TxxP motif of unknown function. Pssm-ID: 409868 [Multi-domain] Cd Length: 75 Bit Score: 116.95 E-value: 5.91e-34
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| RRM_SF | cd00590 | RNA recognition motif (RRM) superfamily; RRM, also known as RBD (RNA binding domain) or RNP ... |
59-129 | 1.96e-04 | ||||
RNA recognition motif (RRM) superfamily; RRM, also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA processing, RNA export, and RNA stability. This domain is 90 amino acids in length and consists of a four-stranded beta-sheet packed against two alpha-helices. RRM usually interacts with ssRNA, but is also known to interact with ssDNA as well as proteins. RRM binds a variable number of nucleotides, ranging from two to eight. The active site includes three aromatic side-chains located within the conserved RNP1 and RNP2 motifs of the domain. The RRM domain is found in a variety heterogeneous nuclear ribonucleoproteins (hnRNPs), proteins implicated in regulation of alternative splicing, and protein components of small nuclear ribonucleoproteins (snRNPs). Pssm-ID: 409669 [Multi-domain] Cd Length: 72 Bit Score: 38.80 E-value: 1.96e-04
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