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Conserved domains on  [gi|1622934688|ref|XP_014991500|]
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tenascin-X isoform X7 [Macaca mulatta]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
4030-4239 4.53e-117

Fibrinogen beta and gamma chains, C-terminal globular domain;


:

Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 370.31  E-value: 4.53e-117
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 4030 FPRDCGEEMQNGAGASRTTTIFLNGNReRPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNIS-GEFWLGN 4108
Cdd:pfam00147    1 FGRDCSDVYNKGAKTSGLYTIRPDGAT-KPFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNLSpGEFWLGN 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 4109 EALHSLTQAGDYSMRVDLRAG-DEAVFAQYDSFRVDSAAEYYRLHLEGYHGTAGD-------SMSYHSGSVFSARDRDPN 4180
Cdd:pfam00147   80 DKIHLLTKQGPYVLRIDLEDWnGETVFALYDSFKVTNENDKYRLHVENYIGDAGDaldtagrSMTYHNGMQFSTWDRDND 159

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622934688 4181 NLLISCAVSYRGAWWYRNCHYANLNG--LYGSTVDHQ-GVSWYYWKGFEFSVPFTEMKLRPR 4239
Cdd:pfam00147  160 SPDGNCALSYGGGWWYNNCHAANLNGvyYYGGTYSKQnGIIWATWKGRWYSMKKAEMKIRPL 221
fn3 pfam00041
Fibronectin type III domain;
3762-3840 1.46e-12

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 65.90  E-value: 1.46e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 3762 SPRDLQFSEIRETSAKVNWMPPPSRA---DSFKVSYQLADGGEP-QSVQVDGRARTQKLQGLIPGARYEVTVVSVRGFEE 3837
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPDGNgpiTGYEVEYRPKNSGEPwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81


                   ...
gi 1622934688 3838 SEP 3840
Cdd:pfam00041   82 GPP 84
fn3 pfam00041
Fibronectin type III domain;
3063-3136 5.23e-12

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 64.36  E-value: 5.23e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934688 3063 PRLGELTVTDATPDSLSLSWTVPE---GQFDHFLVQYRNGDGQ--PKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGG 3136
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2847-2920 5.23e-12

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 64.36  E-value: 5.23e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934688 2847 PRLGELTVTDATPDSLSLSWTVPE---GQFDHFLVQYRNGDGQ--PKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGG 2920
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2631-2704 5.23e-12

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 64.36  E-value: 5.23e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934688 2631 PRLGELTVTDATPDSLSLSWTVPE---GQFDHFLVQYRNGDGQ--PKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGG 2704
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2304-2377 6.61e-12

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 63.97  E-value: 6.61e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934688 2304 PRLGELTMTDATPDSLSLSWTVPE---GQFDHFLVQYKNGDGQ--PKTTRVPGHEDRVTISGLEPDHKYKMNLYGFHGG 2377
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
1991-2061 7.01e-12

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 63.97  E-value: 7.01e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934688 1991 GELTVTDATPDSLSLSWTVPE---GQFDHFLVQYR--NGDGRPKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGG 2061
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRpkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
3310-3674 1.44e-11

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 70.80  E-value: 1.44e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 3310 VPVSGDLRAVTVSGLDPARKYKFLLFGLQNGKRHGPVPVEARTAPDTKLSPRLGeLTVTDATPDSVGLSWT-VPEGEFDS 3388
Cdd:COG3401    185 LTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTG-LTATADTPGSVTLSWDpVTESDATG 263

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 3389 FVVQYK-DKDGRLQVVpVAADQREVTVPGLEPSRKYKFLLYGLAGRKRMGPISaDGTTASLEKEPPPRLGELTVTEETSS 3467
Cdd:COG3401    264 YRVYRSnSGDGPFTKV-ATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPS-NVVSVTTDLTPPAAPSGLTATAVGSS 341

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 3468 SLHLSWT-VAQGPFESFVVqYRDT--DGQPRAVPVAADQHTVTIEDLEPGKKYKFLlyglvggkrlgpVSALGmTAPEED 3544
Cdd:COG3401    342 SITLSWTaSSDADVTGYNV-YRSTsgGGTYTKIAETVTTTSYTDTGLTPGTTYYYK------------VTAVD-AAGNES 407

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 3545 TPAPELASEAPEPPEEPRLGVLAVTDTAPDSMRLSWSVAQGPFDSFVVQYEDTNGQPQALLVDGDQSKILISGLEPSTPY 3624
Cdd:COG3401    408 APSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTA 487

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|
gi 1622934688 3625 RFLLYGLHEGKRLGPLSAEGTTGPAPAGQTSGEPGPRLSQLSVTDVTTSS 3674
Cdd:COG3401    488 NLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVT 537
fn3 pfam00041
Fibronectin type III domain;
1061-1141 2.64e-11

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.43  E-value: 2.64e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 1061 GPPRlgELTVTDRTSDSLLLRWTVPE---GEFDSFVIQYKDRDGQ--PQVVPVEGPQRSAVITSLDPGRKYKFVLYGFVG 1135
Cdd:pfam00041    1 SAPS--NLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78


                   ....*.
gi 1622934688 1136 KKRHGP 1141
Cdd:pfam00041   79 GGEGPP 84
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
1416-1695 3.59e-11

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 69.26  E-value: 3.59e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 1416 VRVGGEESEVTVGGLEPGHKYKMHLYGLHEGQRVGPVSAVGVTAPQqeeTPPAtkPPleprlGELTVTDVTPNSVGLSWT 1495
Cdd:COG3401    185 LTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPT---TPPS--AP-----TGLTATADTPGSVTLSWD 254

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 1496 -VPEGQFDSFMVqYKDKDGQPQAVPVAADQQ-EVTIYNLEPERKYkmnMYglhdgqRVgplSVV----IMTAPLPPAPAT 1569
Cdd:COG3401    255 pVTESDATGYRV-YRSNSGDGPFTKVATVTTtSYTDTGLTNGTTY---YY------RV---TAVdaagNESAPSNVVSVT 321

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 1570 EASEPPLEPRlgELTVTDVTPDSVGLSWT-VPEGEFDSFVVQYKDR-DGQPQVVPVAADQREVTIPGLEPSRKYKFLLFG 1647
Cdd:COG3401    322 TDLTPPAAPS--GLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSgGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTA 399

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1622934688 1648 IQDGKRRSPVSVEA---KTAARGDASPGAPPRLGELWVTDPTPDSLHLSWT 1695
Cdd:COG3401    400 VDAAGNESAPSEEVsatTASAASGESLTASVDAVPLTDVAGATAAASAASN 450
fn3 pfam00041
Fibronectin type III domain;
2195-2268 4.39e-11

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.66  E-value: 4.39e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934688 2195 PRLGEMTVRDATPDSLSLSWTVPE---GQFDHFLVQYKNGDGQ--PKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGG 2268
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
1265-1342 5.60e-11

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.28  E-value: 5.60e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 1265 GELTVTGVTPDSLRLSWT---VAQGPFDSFMVQYKDAQGQ--PQAVPVAGDENEVTVPGLDPDRKYKMNLYGLRGrQRVG 1339
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG-GGEG 82


                   ...
gi 1622934688 1340 PES 1342
Cdd:pfam00041   83 PPS 85
fn3 pfam00041
Fibronectin type III domain;
750-831 6.55e-11

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.28  E-value: 6.55e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  750 PAIEGMRMHLLEETTVRTEWTPAP---GPVDAYEIQFIPTTEGaSPPFTARVPSSASAYDQRGLAPGQEYQVTVRALRGT 826
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSG-EPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*
gi 1622934688  827 SWGPP 831
Cdd:pfam00041   80 GEGPP 84
fn3 pfam00041
Fibronectin type III domain;
843-919 1.27e-10

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 60.51  E-value: 1.27e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  843 PQDLRVVAVTPTTLELGWLRP---QAEVDRFVVSYVSAGNQRVRLE--VPPEADGTLLTDLMPGVEYVVTVTAERGRAVS 917
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEitVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82


                   ..
gi 1622934688  918 YP 919
Cdd:pfam00041   83 PP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1159-1238 2.37e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 59.82  E-value: 2.37e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 1159 PPRLGNLWVTDPTPDSLHLSWTVPE---GQFDTFMVQYRDKDGRP--QVVPVEGPERSFVVSSLDPDHKYRFTLFGIaNK 1233
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAV-NG 79


                   ....*
gi 1622934688 1234 KRYGP 1238
Cdd:cd00063     80 GGESP 84
fn3 pfam00041
Fibronectin type III domain;
3660-3742 8.78e-10

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.20  E-value: 8.78e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 3660 PRLSQLSVTDVTTSSLRLNWEAPP---GAFDSFLLRFgvpSPSTLEPHPRpllqrELMVPGTRHSAVLRDLRPGTLYSLT 3736
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEY---RPKNSGEPWN-----EITVPGTTTSVTLTGLKPGTEYEVR 72


                   ....*.
gi 1622934688 3737 LYGLRG 3742
Cdd:pfam00041   73 VQAVNG 78
fn3 pfam00041
Fibronectin type III domain;
2961-3028 1.55e-09

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.42  E-value: 1.55e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934688 2961 TVTGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDG--RPQVVRVGGEESEVTVGGLEPGRKYKMHLYGLHEG 3028
Cdd:pfam00041    7 TVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2745-2812 1.55e-09

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.42  E-value: 1.55e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934688 2745 TVTGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDG--RPQVVRVGGEESEVTVGGLEPGRKYKMHLYGLHEG 2812
Cdd:pfam00041    7 TVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2529-2596 1.55e-09

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.42  E-value: 1.55e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934688 2529 TVTGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDG--RPQVVRVGGEESEVTVGGLEPGRKYKMHLYGLHEG 2596
Cdd:pfam00041    7 TVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
3177-3244 1.64e-09

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.42  E-value: 1.64e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934688 3177 TVAGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDGQ--PQAVRVGGEESEVTVRGLEPGRKYKMHLYGLYEG 3244
Cdd:pfam00041    7 TVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
1376-1446 2.07e-09

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.04  E-value: 2.07e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934688 1376 GELTVTGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDG--RPQAVRVGGEESEVTVGGLEPGHKYKMHLYGLHEG 1446
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2415-2485 7.44e-09

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.50  E-value: 7.44e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934688 2415 GELTVTGSSPDSLSLSWTIP---QGRFDSFTVQYKDRDG--RPQVVRVGGEESEVTVGSLEPGNKYKMHLYGLHEG 2485
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2102-2169 9.69e-09

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.11  E-value: 9.69e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934688 2102 TVTGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDG--RPQVVRVGGEESEVTVGGLEPGNKYKMHLYGLHEG 2169
Cdd:pfam00041    7 TVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
3270-3332 1.11e-08

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 54.73  E-value: 1.11e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622934688 3270 GELTVAAVTSDSVGLSWT---VAQGPFDSFLVQYR--DTQGQPQAVPVSGDLRAVTVSGLDPARKYKF 3332
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRpkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEV 71
fn3 pfam00041
Fibronectin type III domain;
1672-1739 4.95e-08

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.19  E-value: 4.95e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622934688 1672 GAPPRLGelwVTDPTPDSLHLSWTVPE---GQFDSFVVQFKDKDGPQV---VPVEGHERSVTIAPLDAGRKYRF 1739
Cdd:pfam00041    1 SAPSNLT---VTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPwneITVPGTTTSVTLTGLKPGTEYEV 71
fn3 pfam00041
Fibronectin type III domain;
3939-4016 1.08e-07

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 52.03  E-value: 1.08e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 3939 APRDLEAKEVTPRTALLTWTEPQVRP---TGYLLSFDTPGG--RTQEILLPGGVTSHQLLGLFPSTLYNARLQAMWGESL 4013
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPDGNgpiTGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81


                   ...
gi 1622934688 4014 LPP 4016
Cdd:pfam00041   82 GPP 84
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
3818-4008 1.51e-07

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 57.70  E-value: 1.51e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 3818 GLIPGARYEVTVVSVRGFEESEPLTGFL----TTVPDGPTQLRALNLTEGFAVLHWKPPQNP-VDTYDVQVTAPGAPPLQ 3892
Cdd:COG3401    198 DIEPGTTYYYRVAATDTGGESAPSNEVSvttpTTPPSAPTGLTATADTPGSVTLSWDPVTESdATGYRVYRSNSGDGPFT 277

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 3893 AEAPGSAVDYPLHDLVLHTNYTATVRGLRGPNLTSPAS--ITFTTGLE---APRDLEAKEVTPRTALLTWTE-PQVRPTG 3966
Cdd:COG3401    278 KVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSnvVSVTTDLTppaAPSGLTATAVGSSSITLSWTAsSDADVTG 357

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 1622934688 3967 YLLSFDT-PGGRTQEILLPGGVTSHQLLGLFPSTLYNARLQAM 4008
Cdd:COG3401    358 YNVYRSTsGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAV 400
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1773-1862 2.34e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 2.34e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 1773 PPKPRlgeELQVTSVTQNSVGLSWTVPE---GQFDSFVVQYKDRDGQP--QVVPVEGSLREVSVPGLDPAHRYKLLLYGL 1847
Cdd:cd00063      1 PSPPT---NLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                           90
                   ....*....|....*
gi 1622934688 1848 HSGKRVGPISAVVIT 1862
Cdd:cd00063     78 NGGGESPPSESVTVT 92
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 559-586 6.04e-07

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 48.45  E-value: 6.04e-07
                           10        20
                   ....*....|....*....|....*...
gi 1622934688  559 CPGGCRGRGQCIDGRCVCEDGYSGEDCS 586
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 311-337 9.95e-07

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 47.68  E-value: 9.95e-07
                           10        20
                   ....*....|....*....|....*..
gi 1622934688  311 CPRGCSQRGRCEDGRCVCDPGYTGEDC 337
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 249-275 9.95e-07

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 47.68  E-value: 9.95e-07
                           10        20
                   ....*....|....*....|....*..
gi 1622934688  249 CPRGCSQRGRCEDGRCVCDPGYTGEDC 275
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
PTZ00214 super family cl31756
high cysteine membrane protein Group 4; Provisional
 254-669 1.04e-06

high cysteine membrane protein Group 4; Provisional


The actual alignment was detected with superfamily member PTZ00214:

Pssm-ID: 173479 [Multi-domain]  Cd Length: 800  Bit Score: 55.31  E-value: 1.04e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  254 SQRGRCEDGRCVCDPGYTGedcGMRSCPRGCSQRGRCENGRCvcNPGYTGEDCgvRSCPRGCSQrgrceDGRCVCDPGYT 333
Cdd:PTZ00214   341 SKNDDNNGDGYLCGDATNG---GVSGCATCGYNSGAVTCTRC--SAGYLGVDG--KSCSESCSG-----DTRGVCTKVAE 408

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  334 GEDCGTRSCRwdcgeggrcvdgrCVCWPGYTGEDCSTRTCPRDCrgrGRCEDGE---C-ICDTGYSGDDCGVRSCPGDCN 409
Cdd:PTZ00214   409 GSESTEVSCR-------------CVCKPTFYNSSGTCTPCTDSC---AVCKDGTptgCqQCSPGKILEFSIVSSESADCV 472

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  410 QRGRCEDGRCVCwpGYTgLDcGSRACPRDCRGRGRCENGVCVCNagySGEDCGVRSCPG----DCRGRGRCESGRCVCWP 485
Cdd:PTZ00214   473 DQCSVGSECAEC--GIT-ID-GSRYCTRCKDASTYPFNGVCIPN---TQRDAYCTSTANgactTCSGAAFLMNGGCYTTE 545

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  486 GYTGRDCGTRACPGDC----RGRGRCVDGRCV-CNP---GFTGEDCGS-RRCPGDC-------RGHGSCED-GVCVcDAG 548
Cdd:PTZ00214   546 HYPGSTICDKQSNGKCtttkKGYGISPDGKLLeCDPtclACTAPGPGRcTRCPSDKllkrasgAATGSCVDpGACV-DGY 624

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  549 YSGEDCSTRSCPGGCRGRG------QCIDGRCVCEDGYSgedcsvrrCPNDCSQHGVCQD---GVCICW------EAYVG 613
Cdd:PTZ00214   625 YADGDACLPCATPGCKTCGhasfctECAGELFVSLDGQS--------CLEECTGDKVVGEvsgGVRRCWcergflPALDR 696

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934688  614 EDCSIRT-CPSNCHGRGRCEE-GRCL-CDPGYTGPTCATRMCPADCRGRGRCVQGVCMC 669
Cdd:PTZ00214   697 SGCVLPTeCPPDMPSCAACDEsGRCLlCVTSGHNVQVDQRTCAEGCGARASSNQGVCMC 755
fn3 pfam00041
Fibronectin type III domain;
1885-1955 6.92e-05

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 44.33  E-value: 6.92e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934688 1885 GELTVEEATPHTLHLSWM---VTEGEFDSFEI--QHTDREGQLQTVRTGGDRNDITLSGLESDHRYLVTLYGFHDG 1955
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTpppDGNGPITGYEVeyRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 221-244 3.05e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


:

Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.41  E-value: 3.05e-04
                           10        20
                   ....*....|....*....|....*.
gi 1622934688  221 DCQGRGRCVQ--GVCVCRAGFSGPDC 244
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 719-745 5.50e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 39.97  E-value: 5.50e-04
                           10        20
                   ....*....|....*....|....*..
gi 1622934688  719 CPGDCRGRGECHDGSCICKDGYAGEDC 745
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 190-213 6.56e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


:

Pssm-ID: 400365  Cd Length: 26  Bit Score: 39.64  E-value: 6.56e-04
                           10        20
                   ....*....|....*....|....*.
gi 1622934688  190 DCNDQGRCVR--GRCVCFPGYTGPSC 213
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
 
Name Accession Description Interval E-value
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
4030-4239 4.53e-117

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 370.31  E-value: 4.53e-117
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 4030 FPRDCGEEMQNGAGASRTTTIFLNGNReRPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNIS-GEFWLGN 4108
Cdd:pfam00147    1 FGRDCSDVYNKGAKTSGLYTIRPDGAT-KPFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNLSpGEFWLGN 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 4109 EALHSLTQAGDYSMRVDLRAG-DEAVFAQYDSFRVDSAAEYYRLHLEGYHGTAGD-------SMSYHSGSVFSARDRDPN 4180
Cdd:pfam00147   80 DKIHLLTKQGPYVLRIDLEDWnGETVFALYDSFKVTNENDKYRLHVENYIGDAGDaldtagrSMTYHNGMQFSTWDRDND 159

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622934688 4181 NLLISCAVSYRGAWWYRNCHYANLNG--LYGSTVDHQ-GVSWYYWKGFEFSVPFTEMKLRPR 4239
Cdd:pfam00147  160 SPDGNCALSYGGGWWYNNCHAANLNGvyYYGGTYSKQnGIIWATWKGRWYSMKKAEMKIRPL 221
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
 4030-4239 2.26e-112

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 356.59  E-value: 2.26e-112
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  4030 FPRDCGEEMQNGAGASRTTTIFLNGNReRPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNISGEFWLGNE 4109
Cdd:smart00186    1 LPRDCSDVLQNGGKTSGLYTIYPDGSS-RPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLAGEFWLGNE 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  4110 ALHSLTQAGDYSMRVDLR-AGDEAVFAQYDSFRVDSAAEYYRLHLEGYHGTAGD-SMSYHSGSVFSARDRDPNNLLISCA 4187
Cdd:smart00186   80 NIHLLTSQGKYELRIDLEdWEGNTAYALYDSFKVADEADGYRLHIGGYSGTAGDaSLTYHNGMQFSTYDRDNDKYSGNCA 159

                           170       180       190       200       210
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1622934688  4188 VSYRGAWWYRNCHYANLNGLYGS-TVDHQGVSWYYWKGFEFSVPFTEMKLRPR 4239
Cdd:smart00186  160 EEYGGGWWYNNCHAANLNGRYYPnNNYDNGINWATWKGSWYSLKFTEMKIRPL 212
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 4029-4239 2.98e-110

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 350.77  E-value: 2.98e-110
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 4029 PFPRDCGEEMQNGAGASRTTTIFLNGNReRPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNISGEFWLGN 4108
Cdd:cd00087      1 PLPRDCSEVLQRGGRTSGVYTIQPPGSN-EPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLDGEFWLGL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 4109 EALHSLTQAGDYSMRVDLR-AGDEAVFAQYDSFRVDSAAEYYRLHLEGYHGTAGDSMSYHSGSVFSARDRDPNNLLISCA 4187
Cdd:cd00087     80 EKIHLLTSQGPYELRIDLEdWEGNTAYAEYDSFKVGSESEGYRLTLGGYSGTAGDALSYHNGMKFSTFDRDNDGASGNCA 159

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934688 4188 VSYRGAWWYRNCHYANLNGLYGSTVDHQ----GVSWYYWKGFEFSVPFTEMKLRPR 4239
Cdd:cd00087    160 ESYSGGWWYNSCHASNLNGRYYSGGHRNeydnGINWATWKGSTYSLKFTEMKIRPK 215
fn3 pfam00041
Fibronectin type III domain;
3762-3840 1.46e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 65.90  E-value: 1.46e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 3762 SPRDLQFSEIRETSAKVNWMPPPSRA---DSFKVSYQLADGGEP-QSVQVDGRARTQKLQGLIPGARYEVTVVSVRGFEE 3837
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPDGNgpiTGYEVEYRPKNSGEPwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81


                   ...
gi 1622934688 3838 SEP 3840
Cdd:pfam00041   82 GPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 3763-3842 4.86e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.83  E-value: 4.86e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 3763 PRDLQFSEIRETSAKVNWMPPP---SRADSFKVSYQLADGGEPQSVQVDGRARTQ-KLQGLIPGARYEVTVVSVRGFEES 3838
Cdd:cd00063      4 PTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSyTLTGLKPGTEYEFRVRAVNGGGES 83


                   ....
gi 1622934688 3839 EPLT 3842
Cdd:cd00063     84 PPSE 87
fn3 pfam00041
Fibronectin type III domain;
3063-3136 5.23e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 64.36  E-value: 5.23e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934688 3063 PRLGELTVTDATPDSLSLSWTVPE---GQFDHFLVQYRNGDGQ--PKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGG 3136
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2847-2920 5.23e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 64.36  E-value: 5.23e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934688 2847 PRLGELTVTDATPDSLSLSWTVPE---GQFDHFLVQYRNGDGQ--PKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGG 2920
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2631-2704 5.23e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 64.36  E-value: 5.23e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934688 2631 PRLGELTVTDATPDSLSLSWTVPE---GQFDHFLVQYRNGDGQ--PKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGG 2704
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2304-2377 6.61e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 63.97  E-value: 6.61e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934688 2304 PRLGELTMTDATPDSLSLSWTVPE---GQFDHFLVQYKNGDGQ--PKTTRVPGHEDRVTISGLEPDHKYKMNLYGFHGG 2377
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
1991-2061 7.01e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 63.97  E-value: 7.01e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934688 1991 GELTVTDATPDSLSLSWTVPE---GQFDHFLVQYR--NGDGRPKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGG 2061
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRpkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
3310-3674 1.44e-11

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 70.80  E-value: 1.44e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 3310 VPVSGDLRAVTVSGLDPARKYKFLLFGLQNGKRHGPVPVEARTAPDTKLSPRLGeLTVTDATPDSVGLSWT-VPEGEFDS 3388
Cdd:COG3401    185 LTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTG-LTATADTPGSVTLSWDpVTESDATG 263

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 3389 FVVQYK-DKDGRLQVVpVAADQREVTVPGLEPSRKYKFLLYGLAGRKRMGPISaDGTTASLEKEPPPRLGELTVTEETSS 3467
Cdd:COG3401    264 YRVYRSnSGDGPFTKV-ATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPS-NVVSVTTDLTPPAAPSGLTATAVGSS 341

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 3468 SLHLSWT-VAQGPFESFVVqYRDT--DGQPRAVPVAADQHTVTIEDLEPGKKYKFLlyglvggkrlgpVSALGmTAPEED 3544
Cdd:COG3401    342 SITLSWTaSSDADVTGYNV-YRSTsgGGTYTKIAETVTTTSYTDTGLTPGTTYYYK------------VTAVD-AAGNES 407

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 3545 TPAPELASEAPEPPEEPRLGVLAVTDTAPDSMRLSWSVAQGPFDSFVVQYEDTNGQPQALLVDGDQSKILISGLEPSTPY 3624
Cdd:COG3401    408 APSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTA 487

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|
gi 1622934688 3625 RFLLYGLHEGKRLGPLSAEGTTGPAPAGQTSGEPGPRLSQLSVTDVTTSS 3674
Cdd:COG3401    488 NLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVT 537
fn3 pfam00041
Fibronectin type III domain;
3452-3519 2.40e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.43  E-value: 2.40e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934688 3452 PPPRlgELTVTEETSSSLHLSWT---VAQGPFESFVVQYRDTDGQ--PRAVPVAADQHTVTIEDLEPGKKYKF 3519
Cdd:pfam00041    1 SAPS--NLTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEV 71
fn3 pfam00041
Fibronectin type III domain;
1061-1141 2.64e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.43  E-value: 2.64e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 1061 GPPRlgELTVTDRTSDSLLLRWTVPE---GEFDSFVIQYKDRDGQ--PQVVPVEGPQRSAVITSLDPGRKYKFVLYGFVG 1135
Cdd:pfam00041    1 SAPS--NLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78


                   ....*.
gi 1622934688 1136 KKRHGP 1141
Cdd:pfam00041   79 GGEGPP 84
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1416-1695 3.59e-11

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 69.26  E-value: 3.59e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 1416 VRVGGEESEVTVGGLEPGHKYKMHLYGLHEGQRVGPVSAVGVTAPQqeeTPPAtkPPleprlGELTVTDVTPNSVGLSWT 1495
Cdd:COG3401    185 LTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPT---TPPS--AP-----TGLTATADTPGSVTLSWD 254

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 1496 -VPEGQFDSFMVqYKDKDGQPQAVPVAADQQ-EVTIYNLEPERKYkmnMYglhdgqRVgplSVV----IMTAPLPPAPAT 1569
Cdd:COG3401    255 pVTESDATGYRV-YRSNSGDGPFTKVATVTTtSYTDTGLTNGTTY---YY------RV---TAVdaagNESAPSNVVSVT 321

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 1570 EASEPPLEPRlgELTVTDVTPDSVGLSWT-VPEGEFDSFVVQYKDR-DGQPQVVPVAADQREVTIPGLEPSRKYKFLLFG 1647
Cdd:COG3401    322 TDLTPPAAPS--GLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSgGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTA 399

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1622934688 1648 IQDGKRRSPVSVEA---KTAARGDASPGAPPRLGELWVTDPTPDSLHLSWT 1695
Cdd:COG3401    400 VDAAGNESAPSEEVsatTASAASGESLTASVDAVPLTDVAGATAAASAASN 450
fn3 pfam00041
Fibronectin type III domain;
2195-2268 4.39e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.66  E-value: 4.39e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934688 2195 PRLGEMTVRDATPDSLSLSWTVPE---GQFDHFLVQYKNGDGQ--PKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGG 2268
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
1265-1342 5.60e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.28  E-value: 5.60e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 1265 GELTVTGVTPDSLRLSWT---VAQGPFDSFMVQYKDAQGQ--PQAVPVAGDENEVTVPGLDPDRKYKMNLYGLRGrQRVG 1339
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG-GGEG 82


                   ...
gi 1622934688 1340 PES 1342
Cdd:pfam00041   83 PPS 85
fn3 pfam00041
Fibronectin type III domain;
750-831 6.55e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.28  E-value: 6.55e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  750 PAIEGMRMHLLEETTVRTEWTPAP---GPVDAYEIQFIPTTEGaSPPFTARVPSSASAYDQRGLAPGQEYQVTVRALRGT 826
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSG-EPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*
gi 1622934688  827 SWGPP 831
Cdd:pfam00041   80 GEGPP 84
fn3 pfam00041
Fibronectin type III domain;
1578-1643 1.01e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 60.89  E-value: 1.01e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622934688 1578 PRLGELTVTDVTPDSVGLSWTVPE---GEFDSFVVQYKDRDGQ--PQVVPVAADQREVTIPGLEPSRKYKF 1643
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEV 71
fn3 pfam00041
Fibronectin type III domain;
843-919 1.27e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 60.51  E-value: 1.27e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  843 PQDLRVVAVTPTTLELGWLRP---QAEVDRFVVSYVSAGNQRVRLE--VPPEADGTLLTDLMPGVEYVVTVTAERGRAVS 917
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEitVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82


                   ..
gi 1622934688  918 YP 919
Cdd:pfam00041   83 PP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1159-1238 2.37e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 59.82  E-value: 2.37e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 1159 PPRLGNLWVTDPTPDSLHLSWTVPE---GQFDTFMVQYRDKDGRP--QVVPVEGPERSFVVSSLDPDHKYRFTLFGIaNK 1233
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAV-NG 79


                   ....*
gi 1622934688 1234 KRYGP 1238
Cdd:cd00063     80 GGESP 84
fn3 pfam00041
Fibronectin type III domain;
3660-3742 8.78e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.20  E-value: 8.78e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 3660 PRLSQLSVTDVTTSSLRLNWEAPP---GAFDSFLLRFgvpSPSTLEPHPRpllqrELMVPGTRHSAVLRDLRPGTLYSLT 3736
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEY---RPKNSGEPWN-----EITVPGTTTSVTLTGLKPGTEYEVR 72


                   ....*.
gi 1622934688 3737 LYGLRG 3742
Cdd:pfam00041   73 VQAVNG 78
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1575-1663 1.43e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.89  E-value: 1.43e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 1575 PLEPRlgELTVTDVTPDSVGLSWTVPE---GEFDSFVVQYKDRDGQP--QVVPVAADQREVTIPGLEPSRKYKFLLFGIq 1649
Cdd:cd00063      1 PSPPT--NLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAV- 77

                           90
                   ....*....|....*.
gi 1622934688 1650 DGKRRSPVS--VEAKT 1663
Cdd:cd00063     78 NGGGESPPSesVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
2961-3028 1.55e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.42  E-value: 1.55e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934688 2961 TVTGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDG--RPQVVRVGGEESEVTVGGLEPGRKYKMHLYGLHEG 3028
Cdd:pfam00041    7 TVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2745-2812 1.55e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.42  E-value: 1.55e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934688 2745 TVTGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDG--RPQVVRVGGEESEVTVGGLEPGRKYKMHLYGLHEG 2812
Cdd:pfam00041    7 TVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2529-2596 1.55e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.42  E-value: 1.55e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934688 2529 TVTGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDG--RPQVVRVGGEESEVTVGGLEPGRKYKMHLYGLHEG 2596
Cdd:pfam00041    7 TVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
3177-3244 1.64e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.42  E-value: 1.64e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934688 3177 TVAGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDGQ--PQAVRVGGEESEVTVRGLEPGRKYKMHLYGLYEG 3244
Cdd:pfam00041    7 TVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1156-1227 1.98e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 56.85  E-value: 1.98e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622934688  1156 PGTPPrlgNLWVTDPTPDSLHLSWTVPE-----GQFDTFMVQYRDKDGRPQVVPVEGPERSFVVSSLDPDHKYRFTL 1227
Cdd:smart00060    1 PSPPS---NLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRV 74
fn3 pfam00041
Fibronectin type III domain;
1376-1446 2.07e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.04  E-value: 2.07e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934688 1376 GELTVTGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDG--RPQAVRVGGEESEVTVGGLEPGHKYKMHLYGLHEG 1446
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1062-1131 2.17e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.12  E-value: 2.17e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622934688 1062 PPRLGELTVTDRTSDSLLLRWTVPE---GEFDSFVIQYKDRDGQP--QVVPVEGPQRSAVITSLDPGRKYKFVLY 1131
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVR 75
fn3 pfam00041
Fibronectin type III domain;
1159-1240 3.38e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 56.27  E-value: 3.38e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 1159 PPRlgNLWVTDPTPDSLHLSWTVPE---GQFDTFMVQYRDKDG--RPQVVPVEGPERSFVVSSLDPDHKYRFTLFGIaNK 1233
Cdd:pfam00041    2 APS--NLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV-NG 78


                   ....*..
gi 1622934688 1234 KRYGPLT 1240
Cdd:pfam00041   79 GGEGPPS 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
763-948 3.55e-09

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 63.10  E-value: 3.55e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  763 TTVRTEWTPAPGP-VDAYEIQFIPTTEGaspPFTARVPSSASAYDQRGLAPGQEYQVTVRAL--RGTSWGPPASKTITTM 839
Cdd:COG3401    247 GSVTLSWDPVTESdATGYRVYRSNSGDG---PFTKVATVTTTSYTDTGLTNGTTYYYRVTAVdaAGNESAPSNVVSVTTD 323

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  840 I---DGPQDLRVVAVTPTTLELGW-LRPQAEVDRFVVsYVSAGNQRVRLEVPPEADGTLLTD--LMPGVEYVVTVTA--E 911
Cdd:COG3401    324 LtppAAPSGLTATAVGSSSITLSWtASSDADVTGYNV-YRSTSGGGTYTKIAETVTTTSYTDtgLTPGTTYYYKVTAvdA 402

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 1622934688  912 RGRAVSYPASVRANTGSSPSGllGTTDEPPPSGPSTT 948
Cdd:COG3401    403 AGNESAPSEEVSATTASAASG--ESLTASVDAVPLTD 437
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1061-1128 6.57e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 55.70  E-value: 6.57e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934688  1061 GPPRlgELTVTDRTSDSLLLRWTVPE-----GEFDSFVIQYKDRDGQPQVVPVEGPQRSAVITSLDPGRKYKF 1128
Cdd:smart00060    2 SPPS--NLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 3365-3425 6.79e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.97  E-value: 6.79e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934688 3365 LTVTDATPDSVGLSWTVPE---GEFDSFVVQYKDKDGR--LQVVPVAADQREVTVPGLEPSRKYKF 3425
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGdwKEVEVTPGSETSYTLTGLKPGTEYEF 72
fn3 pfam00041
Fibronectin type III domain;
2415-2485 7.44e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.50  E-value: 7.44e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934688 2415 GELTVTGSSPDSLSLSWTIP---QGRFDSFTVQYKDRDG--RPQVVRVGGEESEVTVGSLEPGNKYKMHLYGLHEG 2485
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 841-921 9.01e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.58  E-value: 9.01e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  841 DGPQDLRVVAVTPTTLELGWLRPQ---AEVDRFVVSYVSAGNQRVRLEVPPEADGT--LLTDLMPGVEYVVTVTAERGRA 915
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETsyTLTGLKPGTEYEFRVRAVNGGG 81


                   ....*.
gi 1622934688  916 VSYPAS 921
Cdd:cd00063     82 ESPPSE 87
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1575-1643 9.07e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.93  E-value: 9.07e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622934688  1575 PLEPRlgELTVTDVTPDSVGLSWTVPE-----GEFDSFVVQYKDRDGQPQVVPVAADQREVTIPGLEPSRKYKF 1643
Cdd:smart00060    1 PSPPS--NLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
fn3 pfam00041
Fibronectin type III domain;
2102-2169 9.69e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.11  E-value: 9.69e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934688 2102 TVTGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDG--RPQVVRVGGEESEVTVGGLEPGNKYKMHLYGLHEG 2169
Cdd:pfam00041    7 TVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
3270-3332 1.11e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 54.73  E-value: 1.11e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622934688 3270 GELTVAAVTSDSVGLSWT---VAQGPFDSFLVQYR--DTQGQPQAVPVSGDLRAVTVSGLDPARKYKF 3332
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRpkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEV 71
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 3452-3519 1.37e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.54  E-value: 1.37e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934688  3452 PPPRlgELTVTEETSSSLHLSWT-----VAQGPFESFVVQYRDTDGQPRAVPVAADQHTVTIEDLEPGKKYKF 3519
Cdd:smart00060    2 SPPS--NLRVTDVTSTSVTLSWEpppddGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2852-2932 2.06e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.42  E-value: 2.06e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 2852 LTVTDATPDSLSLSWTVPE---GQFDHFLVQYRNGDGQP--KAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGGQRVGPV 2926
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPS 86


                   ....*.
gi 1622934688 2927 SVIRVT 2932
Cdd:cd00063     87 ESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 3762-3838 2.74e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.77  E-value: 2.74e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  3762 SPRDLQFSEIRETSAKVNWMPPPS-RADSFKVSYQLADGGEP---QSVQVDGRARTQKLQGLIPGARYEVTVVSVRGFEE 3837
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEPPPDdGITGYIVGYRVEYREEGsewKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGE 82


                    .
gi 1622934688  3838 S 3838
Cdd:smart00060   83 G 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 841-914 4.33e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.00  E-value: 4.33e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934688   841 DGPQDLRVVAVTPTTLELGWLRPQAE-----VDRFVVSYVSAGNQRVRLEVPPEADGTLLTDLMPGVEYVVTVTAERGR 914
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2625-2706 4.78e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 53.27  E-value: 4.78e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 2625 PEPPikprlGELTVTDATPDSLSLSWTVPE---GQFDHFLVQYRNGDGQP--KAVRVPGHEDGVTISGLEPDHKYKMNLY 2699
Cdd:cd00063      1 PSPP-----TNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVR 75


                   ....*..
gi 1622934688 2700 GFHGGQR 2706
Cdd:cd00063     76 AVNGGGE 82
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 3057-3138 4.78e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 53.27  E-value: 4.78e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 3057 PEPPikprlGELTVTDATPDSLSLSWTVPE---GQFDHFLVQYRNGDGQP--KAVRVPGHEDGVTISGLEPDHKYKMNLY 3131
Cdd:cd00063      1 PSPP-----TNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVR 75


                   ....*..
gi 1622934688 3132 GFHGGQR 3138
Cdd:cd00063     76 AVNGGGE 82
fn3 pfam00041
Fibronectin type III domain;
1672-1739 4.95e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.19  E-value: 4.95e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622934688 1672 GAPPRLGelwVTDPTPDSLHLSWTVPE---GQFDSFVVQFKDKDGPQV---VPVEGHERSVTIAPLDAGRKYRF 1739
Cdd:pfam00041    1 SAPSNLT---VTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPwneITVPGTTTSVTLTGLKPGTEYEV 71
fn3 pfam00041
Fibronectin type III domain;
3939-4016 1.08e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 52.03  E-value: 1.08e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 3939 APRDLEAKEVTPRTALLTWTEPQVRP---TGYLLSFDTPGG--RTQEILLPGGVTSHQLLGLFPSTLYNARLQAMWGESL 4013
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPDGNgpiTGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81


                   ...
gi 1622934688 4014 LPP 4016
Cdd:pfam00041   82 GPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1993-2073 1.18e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.11  E-value: 1.18e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 1993 LTVTDATPDSLSLSWTVPE---GQFDHFLVQYRNGDGRP--KAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGGQRVGPV 2067
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPS 86


                   ....*.
gi 1622934688 2068 SAIGVT 2073
Cdd:cd00063     87 ESVTVT 92
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
3818-4008 1.51e-07

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 57.70  E-value: 1.51e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 3818 GLIPGARYEVTVVSVRGFEESEPLTGFL----TTVPDGPTQLRALNLTEGFAVLHWKPPQNP-VDTYDVQVTAPGAPPLQ 3892
Cdd:COG3401    198 DIEPGTTYYYRVAATDTGGESAPSNEVSvttpTTPPSAPTGLTATADTPGSVTLSWDPVTESdATGYRVYRSNSGDGPFT 277

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 3893 AEAPGSAVDYPLHDLVLHTNYTATVRGLRGPNLTSPAS--ITFTTGLE---APRDLEAKEVTPRTALLTWTE-PQVRPTG 3966
Cdd:COG3401    278 KVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSnvVSVTTDLTppaAPSGLTATAVGSSSITLSWTAsSDADVTG 357

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 1622934688 3967 YLLSFDT-PGGRTQEILLPGGVTSHQLLGLFPSTLYNARLQAM 4008
Cdd:COG3401    358 YNVYRSTsGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAV 400
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1267-1347 1.71e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.73  E-value: 1.71e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 1267 LTVTGVTPDSLRLSWTVAQ---GPFDSFMVQYKDAQGQP--QAVPVAGDENEVTVPGLDPDRKYKMNLYGLRGRQRVGP- 1340
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPs 86


                   ....*..
gi 1622934688 1341 ESVVAKT 1347
Cdd:cd00063     87 ESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2745-2824 2.08e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.73  E-value: 2.08e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 2745 TVTGSSPDSLSLSWTVPQ---GRFDSFTVQYKDRDGRP--QVVRVGGEESEVTVGGLEPGRKYKMHLYGLHEGQRVGPVS 2819
Cdd:cd00063      8 RVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSE 87


                   ....*
gi 1622934688 2820 AVGVT 2824
Cdd:cd00063     88 SVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2961-3040 2.34e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 2.34e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 2961 TVTGSSPDSLSLSWTVPQ---GRFDSFTVQYKDRDGRP--QVVRVGGEESEVTVGGLEPGRKYKMHLYGLHEGRRVGPVS 3035
Cdd:cd00063      8 RVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSE 87


                   ....*
gi 1622934688 3036 AVGVT 3040
Cdd:cd00063     88 SVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1773-1862 2.34e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 2.34e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 1773 PPKPRlgeELQVTSVTQNSVGLSWTVPE---GQFDSFVVQYKDRDGQP--QVVPVEGSLREVSVPGLDPAHRYKLLLYGL 1847
Cdd:cd00063      1 PSPPT---NLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                           90
                   ....*....|....*
gi 1622934688 1848 HSGKRVGPISAVVIT 1862
Cdd:cd00063     78 NGGGESPPSESVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 3938-4023 2.53e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 2.53e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 3938 EAPRDLEAKEVTPRTALLTWTEPQ---VRPTGYLLSF-DTPGGRTQEI-LLPGGVTSHQLLGLFPSTLYNARLQAM--WG 4010
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYrEKGSGDWKEVeVTPGSETSYTLTGLKPGTEYEFRVRAVngGG 81

                           90
                   ....*....|...
gi 1622934688 4011 ESlLPPVSTSFTT 4023
Cdd:cd00063     82 ES-PPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 750-838 2.63e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 2.63e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  750 PAIEGMRMHLLEETTVRTEWTPAP---GPVDAYEIQFIPTTEGASPPFTARVPSSASaYDQRGLAPGQEYQVTVRALRGT 826
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETS-YTLTGLKPGTEYEFRVRAVNGG 80

                           90
                   ....*....|...
gi 1622934688  827 SWGPPA-SKTITT 838
Cdd:cd00063     81 GESPPSeSVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2625-2699 2.74e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.08  E-value: 2.74e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  2625 PEPPikprlGELTVTDATPDSLSLSWTVPE-----GQFDHFLVQYRNGDGQPKAVRVPGHEDGVTISGLEPDHKYKMNLY 2699
Cdd:smart00060    1 PSPP-----SNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 3057-3131 2.74e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.08  E-value: 2.74e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  3057 PEPPikprlGELTVTDATPDSLSLSWTVPE-----GQFDHFLVQYRNGDGQPKAVRVPGHEDGVTISGLEPDHKYKMNLY 3131
Cdd:smart00060    1 PSPP-----SNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2102-2181 3.14e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.96  E-value: 3.14e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 2102 TVTGSSPDSLSLSWTVPQ---GRFDSFTVQYKDRDGRP--QVVRVGGEESEVTVGGLEPGNKYKMHLYGLHEGRRVGPVS 2176
Cdd:cd00063      8 RVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSE 87


                   ....*
gi 1622934688 2177 AVGVT 2181
Cdd:cd00063     88 SVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2309-2389 3.49e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.96  E-value: 3.49e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 2309 LTMTDATPDSLSLSWTVPE---GQFDHFLVQYKNGDGQP--KTTRVPGHEDRVTISGLEPDHKYKMNLYGFHGGQRVGPV 2383
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPS 86


                   ....*.
gi 1622934688 2384 SAIGVT 2389
Cdd:cd00063     87 ESVTVT 92
fn3 pfam00041
Fibronectin type III domain;
1774-1857 4.59e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 50.49  E-value: 4.59e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 1774 PKPRlgeELQVTSVTQNSVGLSWTVPE---GQFDSFVVQYKDRDGQ--PQVVPVEGSLREVSVPGLDPAHRYKLLLYGlH 1848
Cdd:pfam00041    1 SAPS---NLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQA-V 76


                   ....*....
gi 1622934688 1849 SGKRVGPIS 1857
Cdd:pfam00041   77 NGGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1671-1739 5.64e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.19  E-value: 5.64e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622934688 1671 PGAPprlGELWVTDPTPDSLHLSWTVPE---GQFDSFVVQFKDKDGPQVVPVE---GHERSVTIAPLDAGRKYRF 1739
Cdd:cd00063      1 PSPP---TNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEvtpGSETSYTLTGLKPGTEYEF 72
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 3939-4007 5.77e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.92  E-value: 5.77e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622934688  3939 APRDLEAKEVTPRTALLTWTEPQVRP-----TGYLLSFDTPGGRTQEILLPGGVTSHQLLGLFPSTLYNARLQA 4007
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEPPPDDGitgyiVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 559-586 6.04e-07

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 48.45  E-value: 6.04e-07
                           10        20
                   ....*....|....*....|....*...
gi 1622934688  559 CPGGCRGRGQCIDGRCVCEDGYSGEDCS 586
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2188-2277 6.65e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.19  E-value: 6.65e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 2188 PDAPlvkprlGEMTVRDATPDSLSLSWTVPE---GQFDHFLVQYKNGDGQP--KAVRVPGHEDGVTISGLEPDHKYKMNL 2262
Cdd:cd00063      1 PSPP------TNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRV 74

                           90
                   ....*....|....*
gi 1622934688 2263 YGFHGGQRMGPVSAV 2277
Cdd:cd00063     75 RAVNGGGESPPSESV 89
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2529-2591 6.98e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.19  E-value: 6.98e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622934688 2529 TVTGSSPDSLSLSWTVPQ---GRFDSFTVQYKDRDGRP--QVVRVGGEESEVTVGGLEPGRKYKMHLY 2591
Cdd:cd00063      8 RVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2844-2915 8.04e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.54  E-value: 8.04e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622934688  2844 PIKPRlgELTVTDATPDSLSLSWTVPE-----GQFDHFLVQYRNGDGQPKAVRVPGHEDGVTISGLEPDHKYKMNLY 2915
Cdd:smart00060    1 PSPPS--NLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1378-1441 9.41e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.54  E-value: 9.41e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934688  1378 LTVTGSSPDSLSLSWTVPQ-----GRFDSFTVQYKDRDGRPQAVRVGGEESEVTVGGLEPGHKYKMHLY 1441
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1993-2056 9.78e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.54  E-value: 9.78e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934688  1993 LTVTDATPDSLSLSWTVPE-----GQFDHFLVQYRNGDGRPKAVRVPGHEDGVTISGLEPDHKYKMNLY 2056
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 311-337 9.95e-07

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 47.68  E-value: 9.95e-07
                           10        20
                   ....*....|....*....|....*..
gi 1622934688  311 CPRGCSQRGRCEDGRCVCDPGYTGEDC 337
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 249-275 9.95e-07

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 47.68  E-value: 9.95e-07
                           10        20
                   ....*....|....*....|....*..
gi 1622934688  249 CPRGCSQRGRCEDGRCVCDPGYTGEDC 275
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
PTZ00214 PTZ00214
high cysteine membrane protein Group 4; Provisional
 254-669 1.04e-06

high cysteine membrane protein Group 4; Provisional


Pssm-ID: 173479 [Multi-domain]  Cd Length: 800  Bit Score: 55.31  E-value: 1.04e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  254 SQRGRCEDGRCVCDPGYTGedcGMRSCPRGCSQRGRCENGRCvcNPGYTGEDCgvRSCPRGCSQrgrceDGRCVCDPGYT 333
Cdd:PTZ00214   341 SKNDDNNGDGYLCGDATNG---GVSGCATCGYNSGAVTCTRC--SAGYLGVDG--KSCSESCSG-----DTRGVCTKVAE 408

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  334 GEDCGTRSCRwdcgeggrcvdgrCVCWPGYTGEDCSTRTCPRDCrgrGRCEDGE---C-ICDTGYSGDDCGVRSCPGDCN 409
Cdd:PTZ00214   409 GSESTEVSCR-------------CVCKPTFYNSSGTCTPCTDSC---AVCKDGTptgCqQCSPGKILEFSIVSSESADCV 472

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  410 QRGRCEDGRCVCwpGYTgLDcGSRACPRDCRGRGRCENGVCVCNagySGEDCGVRSCPG----DCRGRGRCESGRCVCWP 485
Cdd:PTZ00214   473 DQCSVGSECAEC--GIT-ID-GSRYCTRCKDASTYPFNGVCIPN---TQRDAYCTSTANgactTCSGAAFLMNGGCYTTE 545

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  486 GYTGRDCGTRACPGDC----RGRGRCVDGRCV-CNP---GFTGEDCGS-RRCPGDC-------RGHGSCED-GVCVcDAG 548
Cdd:PTZ00214   546 HYPGSTICDKQSNGKCtttkKGYGISPDGKLLeCDPtclACTAPGPGRcTRCPSDKllkrasgAATGSCVDpGACV-DGY 624

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  549 YSGEDCSTRSCPGGCRGRG------QCIDGRCVCEDGYSgedcsvrrCPNDCSQHGVCQD---GVCICW------EAYVG 613
Cdd:PTZ00214   625 YADGDACLPCATPGCKTCGhasfctECAGELFVSLDGQS--------CLEECTGDKVVGEvsgGVRRCWcergflPALDR 696

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934688  614 EDCSIRT-CPSNCHGRGRCEE-GRCL-CDPGYTGPTCATRMCPADCRGRGRCVQGVCMC 669
Cdd:PTZ00214   697 SGCVLPTeCPPDMPSCAACDEsGRCLlCVTSGHNVQVDQRTCAEGCGARASSNQGVCMC 755
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2417-2497 1.14e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.42  E-value: 1.14e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 2417 LTVTGSSPDSLSLSWTIPQ---GRFDSFTVQYKDRDGRP--QVVRVGGEESEVTVGSLEPGNKYKMHLYGLHEGRRVGPV 2491
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPS 86


                   ....*.
gi 1622934688 2492 SAVGVT 2497
Cdd:cd00063     87 ESVTVT 92
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 373-399 1.14e-06

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 47.68  E-value: 1.14e-06
                           10        20
                   ....*....|....*....|....*..
gi 1622934688  373 CPRDCRGRGRCEDGECICDTGYSGDDC 399
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 3177-3253 1.44e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.03  E-value: 1.44e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 3177 TVAGSSPDSLSLSWTVPQ---GRFDSFTVQYKDRDGQP--QAVRVGGEESEVTVRGLEPGRKYKMHLYGLYEGRRVGPVS 3251
Cdd:cd00063      8 RVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSE 87


                   ..
gi 1622934688 3252 AV 3253
Cdd:cd00063     88 SV 89
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1267-1330 1.59e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.76  E-value: 1.59e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934688  1267 LTVTGVTPDSLRLSWT-----VAQGPFDSFMVQYKDAQGQPQAVPVAGDENEVTVPGLDPDRKYKMNLY 1330
Cdd:smart00060    7 LRVTDVTSTSVTLSWEpppddGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2745-2807 2.29e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.38  E-value: 2.29e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622934688  2745 TVTGSSPDSLSLSWTVPQ-----GRFDSFTVQYKDRDGRPQVVRVGGEESEVTVGGLEPGRKYKMHLY 2807
Cdd:smart00060    8 RVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2961-3023 2.29e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.38  E-value: 2.29e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622934688  2961 TVTGSSPDSLSLSWTVPQ-----GRFDSFTVQYKDRDGRPQVVRVGGEESEVTVGGLEPGRKYKMHLY 3023
Cdd:smart00060    8 RVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2529-2591 2.29e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.38  E-value: 2.29e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622934688  2529 TVTGSSPDSLSLSWTVPQ-----GRFDSFTVQYKDRDGRPQVVRVGGEESEVTVGGLEPGRKYKMHLY 2591
Cdd:smart00060    8 RVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2309-2372 3.22e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.99  E-value: 3.22e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934688  2309 LTMTDATPDSLSLSWTVPE-----GQFDHFLVQYKNGDGQPKTTRVPGHEDRVTISGLEPDHKYKMNLY 2372
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 3663-3738 3.35e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.99  E-value: 3.35e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622934688  3663 SQLSVTDVTTSSLRLNWEAPPGA-FDSFLLRFgvpspsTLEPHPRPLLQRELMVPGTRHSAVLRDLRPGTLYSLTLY 3738
Cdd:smart00060    5 SNLRVTDVTSTSVTLSWEPPPDDgITGYIVGY------RVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2102-2164 3.35e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.99  E-value: 3.35e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622934688  2102 TVTGSSPDSLSLSWTVPQ-----GRFDSFTVQYKDRDGRPQVVRVGGEESEVTVGGLEPGNKYKMHLY 2164
Cdd:smart00060    8 RVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2188-2263 4.16e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.61  E-value: 4.16e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  2188 PDAPlvkprlGEMTVRDATPDSLSLSWTVPE-----GQFDHFLVQYKNGDGQPKAVRVPGHEDGVTISGLEPDHKYKMNL 2262
Cdd:smart00060    1 PSPP------SNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRV 74


                    .
gi 1622934688  2263 Y 2263
Cdd:smart00060   75 R 75
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
314-418 4.19e-06

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 49.37  E-value: 4.19e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  314 GCSQRG-RCEDGRCVC-----DPGYTGEDCGtrSCRWDCGEGGRCVDGRCVCWPGYT--GEDC-STRTCPRDCRGRGR-- 382
Cdd:NF041328    13 GCPEPGaVCPEGLSVCggacvDLRSDPSNCG--ACGVACGAGQTCVAGACGCGPGTVacGGACvDTASDPAHCGACGAac 90

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1622934688  383 -----CEDGEC--ICDTGYS--GDDC-GVRSCPGDCNQRG-RCEDGR 418
Cdd:NF041328    91 apgqvCEGGACreACSEGLTrcGGACvDLATDPLHCGACGvACDPGE 137
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1671-1739 4.68e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.61  E-value: 4.68e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622934688  1671 PGAPPRLgelWVTDPTPDSLHLSWTVPE-GQFDSFVVQFKDKDGP-----QVVPVEGHERSVTIAPLDAGRKYRF 1739
Cdd:smart00060    1 PSPPSNL---RVTDVTSTSVTLSWEPPPdDGITGYIVGYRVEYREegsewKEVNVTPSSTSYTLTGLKPGTEYEF 72
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2417-2480 5.86e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.22  E-value: 5.86e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934688  2417 LTVTGSSPDSLSLSWTIPQ-----GRFDSFTVQYKDRDGRPQVVRVGGEESEVTVGSLEPGNKYKMHLY 2480
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1773-1842 6.39e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.22  E-value: 6.39e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622934688  1773 PPKPRlgeELQVTSVTQNSVGLSWTVPE-----GQFDSFVVQYKDRDGQPQVVPVEGSLREVSVPGLDPAHRYKL 1842
Cdd:smart00060    1 PSPPS---NLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 3177-3244 7.78e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.84  E-value: 7.78e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934688  3177 TVAGSSPDSLSLSWTVPQ-----GRFDSFTVQYKDRDGQPQAVRVGGEESEVTVRGLEPGRKYKMHLYGLYEG 3244
Cdd:smart00060    8 RVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
594-703 9.38e-06

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 48.22  E-value: 9.38e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  594 CSQHG-VCQDGVCICWEAYVgedcSIRTCPSNCHGRG-------RCEEGRCLCDPGYT--GPTC-ATRMCPADCRGRGR- 661
Cdd:NF041328    14 CPEPGaVCPEGLSVCGGACV----DLRSDPSNCGACGvacgagqTCVAGACGCGPGTVacGGACvDTASDPAHCGACGAa 89

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1622934688  662 ------CVQGVCMCHVGYGGEDCGQ-------EEPPASACPGGCGPRELCQAGQC 703
Cdd:NF041328    90 capgqvCEGGACREACSEGLTRCGGacvdlatDPLHCGACGVACDPGESCRGGAC 144
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 3849-3935 1.44e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 46.34  E-value: 1.44e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 3849 PDGPTQLRALNLTEGFAVLHWKPPQN---PVDTYDVQVTAPGAPPLQ--AEAPGSAVDYPLHDLVLHTNYTATVRGLRGP 3923
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDdggPITGYVVEYREKGSGDWKevEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                           90
                   ....*....|...
gi 1622934688 3924 NLTSPA-SITFTT 3935
Cdd:cd00063     81 GESPPSeSVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 3272-3332 1.72e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.68  E-value: 1.72e-05
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934688  3272 LTVAAVTSDSVGLSWT-----VAQGPFDSFLVQYRDTQGQPQAVPVSGDLRAVTVSGLDPARKYKF 3332
Cdd:smart00060    7 LRVTDVTSTSVTLSWEpppddGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
fn3 pfam00041
Fibronectin type III domain;
3852-3922 3.10e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 45.10  E-value: 3.10e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934688 3852 PTQLRALNLTEGFAVLHWKPP---QNPVDTYDVQVTAPGAPPLQAE--APGSAVDYPLHDLVLHTNYTATVRGLRG 3922
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEitVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 3663-3738 3.57e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.18  E-value: 3.57e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934688 3663 SQLSVTDVTTSSLRLNWEAPP---GAFDSFLLRFGVPSPSTLEPHPRPllqrelmvPGTRHSAVLRDLRPGTLYSLTLY 3738
Cdd:cd00063      5 TNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVT--------PGSETSYTLTGLKPGTEYEFRVR 75
fn3 pfam00041
Fibronectin type III domain;
1885-1955 6.92e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 44.33  E-value: 6.92e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934688 1885 GELTVEEATPHTLHLSWM---VTEGEFDSFEI--QHTDREGQLQTVRTGGDRNDITLSGLESDHRYLVTLYGFHDG 1955
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTpppDGNGPITGYEVeyRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 3849-3918 1.89e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.99  E-value: 1.89e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622934688  3849 PDGPTQLRALNLTEGFAVLHWKPPQNP-----VDTYDVQVTAPGAPPLQAEAPGSAVDYPLHDLVLHTNYTATVR 3918
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 221-244 3.05e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.41  E-value: 3.05e-04
                           10        20
                   ....*....|....*....|....*.
gi 1622934688  221 DCQGRGRCVQ--GVCVCRAGFSGPDC 244
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 750-829 3.08e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.22  E-value: 3.08e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688   750 PAIEGMRMHLLEETTVRTEWTPAPGP-VDAYEIQFIPTTEGASPPF-TARVPSSASAYDQRGLAPGQEYQVTVRALRGTS 827
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgITGYIVGYRVEYREEGSEWkEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1622934688   828 WG 829
Cdd:smart00060   82 EG 83
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
279-414 5.42e-04

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 43.21  E-value: 5.42e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  279 SCPRGCSqrgRCeNGRCVCNPGyTGEDCGvrSCPRGCSQRGRCEDGRCVCDPGytGEDCG-----TRSCRWDCGE-GGRC 352
Cdd:NF041328    20 VCPEGLS---VC-GGACVDLRS-DPSNCG--ACGVACGAGQTCVAGACGCGPG--TVACGgacvdTASDPAHCGAcGAAC 90

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622934688  353 VDGRcVCWPGYTGEDCSTrtcprdcrGRGRCeDGECI---CDTGYSGdDCGVRSCPGDCNQRGRC 414
Cdd:NF041328    91 APGQ-VCEGGACREACSE--------GLTRC-GGACVdlaTDPLHCG-ACGVACDPGESCRGGAC 144
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 719-745 5.50e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 39.97  E-value: 5.50e-04
                           10        20
                   ....*....|....*....|....*..
gi 1622934688  719 CPGDCRGRGECHDGSCICKDGYAGEDC 745
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1887-1950 5.82e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 41.45  E-value: 5.82e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934688  1887 LTVEEATPHTLHLSWM-----VTEGEFDSFEIQHTDREGQLQTVRTGGDRNDITLSGLESDHRYLVTLY 1950
Cdd:smart00060    7 LRVTDVTSTSVTLSWEpppddGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
191-295 6.19e-04

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 43.21  E-value: 6.19e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  191 CNDQGRCVRGRCVCFPGYTgpSCGwpscpgdcqgrGRCVQ--------GVC--VCRAGFSgpdCSQRSCPRGCSQ-RGRC 259
Cdd:NF041328    49 CGAGQTCVAGACGCGPGTV--ACG-----------GACVDtasdpahcGACgaACAPGQV---CEGGACREACSEgLTRC 112

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1622934688  260 eDGRCV---CDPGYTGEdCGmRSCPRGCSqrgrCENGRC 295
Cdd:NF041328   113 -GGACVdlaTDPLHCGA-CG-VACDPGES----CRGGAC 144
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 190-213 6.56e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 39.64  E-value: 6.56e-04
                           10        20
                   ....*....|....*....|....*.
gi 1622934688  190 DCNDQGRCVR--GRCVCFPGYTGPSC 213
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
492-590 8.01e-04

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 42.82  E-value: 8.01e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  492 CGtrACPGDCRGRGRCVDGRCVCNPGFT--GEDCGSRR--------CPGDCRGHGSCEDGVC--VCDAGYsgEDCStRSC 559
Cdd:NF041328    42 CG--ACGVACGAGQTCVAGACGCGPGTVacGGACVDTAsdpahcgaCGAACAPGQVCEGGACreACSEGL--TRCG-GAC 116

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1622934688  560 PGGCRGRGQCidGRC--VCEDgysGEDCSVRRC 590
Cdd:NF041328   117 VDLATDPLHC--GACgvACDP---GESCRGGAC 144
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
416-543 1.23e-03

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 42.05  E-value: 1.23e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  416 DGRCVCWPGyTGLDCGsrACPRDCRGRGRCENGVCVCNAGysGEDCG-----VRSCPGDCrgrGRCESgrcVCWPGYTgr 490
Cdd:NF041328    29 GGACVDLRS-DPSNCG--ACGVACGAGQTCVAGACGCGPG--TVACGgacvdTASDPAHC---GACGA---ACAPGQV-- 95

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1622934688  491 dCGTRACPGDC-RGRGRCvDGRCVcNPGFTGEDCGSrrCPGDCRGHGSCEDGVC 543
Cdd:NF041328    96 -CEGGACREACsEGLTRC-GGACV-DLATDPLHCGA--CGVACDPGESCRGGAC 144
dnaA PRK14086
chromosomal replication initiator protein DnaA;
884-1212 1.35e-03

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 44.82  E-value: 1.35e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  884 LEVPPE-ADGTLLTDLMPGVEYvvTVTAERGRAVSYPASVRANTGSSPsgllgttdePPPSGPSTTQGAQAPLLQQRPQE 962
Cdd:PRK14086    51 LAVPNEfAKEVLEGRLAPIISE--TLSRELGRPIRIAITVDPSAGEPA---------PPPPHARRTSEPELPRPGRRPYE 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  963 lgelrVLGRDETGRLRVVWTAQPdtfahfQLRLRVPEGPGAHEEVLPGDVrqalvPPPAPGAPYELSLRGVPPGGKPSDP 1042
Cdd:PRK14086   120 -----GYGGPRADDRPPGLPRQD------QLPTARPAYPAYQQRPEPGAW-----PRAADDYGWQQQRLGFPPRAPYASP 183

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 1043 VIYQGIMDKDEEKPG--KSSGPPRLGEltvtdrtsdslllrWTVPEGEFDsfviqYKDRDGQPQVVPVEGPQrsavitsl 1120
Cdd:PRK14086   184 ASYAPEQERDREPYDagRPEYDQRRRD--------------YDHPRPDWD-----RPRRDRTDRPEPPPGAG-------- 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 1121 dpgrkykfvlygfvGKKRHGPLVTEAKILPQSDPRPGTPPRLGNLWVTDPTPDSLHLSWTvPEGQFDTFMVQYRDKDGRP 1200
Cdd:PRK14086   237 --------------HVHRGGPGPPERDDAPVVPIRPSAPGPLAAQPAPAPGPGEPTARLN-PKYTFDTFVIGASNRFAHA 301

                          330
                   ....*....|...
gi 1622934688 1201 QVVPV-EGPERSF 1212
Cdd:PRK14086   302 AAVAVaEAPAKAY 314
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 4059-4073 1.79e-03

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 38.70  E-value: 1.79e-03
                           10
                   ....*....|....*
gi 1622934688 4059 PLNVFCDMETDGGGW 4073
Cdd:NF040941    29 PFQVYCDMTTDGGGW 43
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1887-1955 2.15e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 40.17  E-value: 2.15e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622934688 1887 LTVEEATPHTLHLSWMV---TEGEFDSFEIQHTDR-EGQLQTVRTG-GDRNDITLSGLESDHRYLVTLYGFHDG 1955
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPpedDGGPITGYVVEYREKgSGDWKEVEVTpGSETSYTLTGLKPGTEYEFRVRAVNGG 80
 
Name Accession Description Interval E-value
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
4030-4239 4.53e-117

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 370.31  E-value: 4.53e-117
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 4030 FPRDCGEEMQNGAGASRTTTIFLNGNReRPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNIS-GEFWLGN 4108
Cdd:pfam00147    1 FGRDCSDVYNKGAKTSGLYTIRPDGAT-KPFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNLSpGEFWLGN 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 4109 EALHSLTQAGDYSMRVDLRAG-DEAVFAQYDSFRVDSAAEYYRLHLEGYHGTAGD-------SMSYHSGSVFSARDRDPN 4180
Cdd:pfam00147   80 DKIHLLTKQGPYVLRIDLEDWnGETVFALYDSFKVTNENDKYRLHVENYIGDAGDaldtagrSMTYHNGMQFSTWDRDND 159

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622934688 4181 NLLISCAVSYRGAWWYRNCHYANLNG--LYGSTVDHQ-GVSWYYWKGFEFSVPFTEMKLRPR 4239
Cdd:pfam00147  160 SPDGNCALSYGGGWWYNNCHAANLNGvyYYGGTYSKQnGIIWATWKGRWYSMKKAEMKIRPL 221
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
 4030-4239 2.26e-112

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 356.59  E-value: 2.26e-112
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  4030 FPRDCGEEMQNGAGASRTTTIFLNGNReRPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNISGEFWLGNE 4109
Cdd:smart00186    1 LPRDCSDVLQNGGKTSGLYTIYPDGSS-RPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLAGEFWLGNE 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  4110 ALHSLTQAGDYSMRVDLR-AGDEAVFAQYDSFRVDSAAEYYRLHLEGYHGTAGD-SMSYHSGSVFSARDRDPNNLLISCA 4187
Cdd:smart00186   80 NIHLLTSQGKYELRIDLEdWEGNTAYALYDSFKVADEADGYRLHIGGYSGTAGDaSLTYHNGMQFSTYDRDNDKYSGNCA 159

                           170       180       190       200       210
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1622934688  4188 VSYRGAWWYRNCHYANLNGLYGS-TVDHQGVSWYYWKGFEFSVPFTEMKLRPR 4239
Cdd:smart00186  160 EEYGGGWWYNNCHAANLNGRYYPnNNYDNGINWATWKGSWYSLKFTEMKIRPL 212
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 4029-4239 2.98e-110

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 350.77  E-value: 2.98e-110
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 4029 PFPRDCGEEMQNGAGASRTTTIFLNGNReRPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNISGEFWLGN 4108
Cdd:cd00087      1 PLPRDCSEVLQRGGRTSGVYTIQPPGSN-EPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLDGEFWLGL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 4109 EALHSLTQAGDYSMRVDLR-AGDEAVFAQYDSFRVDSAAEYYRLHLEGYHGTAGDSMSYHSGSVFSARDRDPNNLLISCA 4187
Cdd:cd00087     80 EKIHLLTSQGPYELRIDLEdWEGNTAYAEYDSFKVGSESEGYRLTLGGYSGTAGDALSYHNGMKFSTFDRDNDGASGNCA 159

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934688 4188 VSYRGAWWYRNCHYANLNGLYGSTVDHQ----GVSWYYWKGFEFSVPFTEMKLRPR 4239
Cdd:cd00087    160 ESYSGGWWYNSCHASNLNGRYYSGGHRNeydnGINWATWKGSTYSLKFTEMKIRPK 215
fn3 pfam00041
Fibronectin type III domain;
3762-3840 1.46e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 65.90  E-value: 1.46e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 3762 SPRDLQFSEIRETSAKVNWMPPPSRA---DSFKVSYQLADGGEP-QSVQVDGRARTQKLQGLIPGARYEVTVVSVRGFEE 3837
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPDGNgpiTGYEVEYRPKNSGEPwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81


                   ...
gi 1622934688 3838 SEP 3840
Cdd:pfam00041   82 GPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 3763-3842 4.86e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.83  E-value: 4.86e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 3763 PRDLQFSEIRETSAKVNWMPPP---SRADSFKVSYQLADGGEPQSVQVDGRARTQ-KLQGLIPGARYEVTVVSVRGFEES 3838
Cdd:cd00063      4 PTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSyTLTGLKPGTEYEFRVRAVNGGGES 83


                   ....
gi 1622934688 3839 EPLT 3842
Cdd:cd00063     84 PPSE 87
fn3 pfam00041
Fibronectin type III domain;
3063-3136 5.23e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 64.36  E-value: 5.23e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934688 3063 PRLGELTVTDATPDSLSLSWTVPE---GQFDHFLVQYRNGDGQ--PKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGG 3136
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2847-2920 5.23e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 64.36  E-value: 5.23e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934688 2847 PRLGELTVTDATPDSLSLSWTVPE---GQFDHFLVQYRNGDGQ--PKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGG 2920
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2631-2704 5.23e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 64.36  E-value: 5.23e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934688 2631 PRLGELTVTDATPDSLSLSWTVPE---GQFDHFLVQYRNGDGQ--PKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGG 2704
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2304-2377 6.61e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 63.97  E-value: 6.61e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934688 2304 PRLGELTMTDATPDSLSLSWTVPE---GQFDHFLVQYKNGDGQ--PKTTRVPGHEDRVTISGLEPDHKYKMNLYGFHGG 2377
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
1991-2061 7.01e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 63.97  E-value: 7.01e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934688 1991 GELTVTDATPDSLSLSWTVPE---GQFDHFLVQYR--NGDGRPKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGG 2061
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRpkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
3310-3674 1.44e-11

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 70.80  E-value: 1.44e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 3310 VPVSGDLRAVTVSGLDPARKYKFLLFGLQNGKRHGPVPVEARTAPDTKLSPRLGeLTVTDATPDSVGLSWT-VPEGEFDS 3388
Cdd:COG3401    185 LTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTG-LTATADTPGSVTLSWDpVTESDATG 263

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 3389 FVVQYK-DKDGRLQVVpVAADQREVTVPGLEPSRKYKFLLYGLAGRKRMGPISaDGTTASLEKEPPPRLGELTVTEETSS 3467
Cdd:COG3401    264 YRVYRSnSGDGPFTKV-ATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPS-NVVSVTTDLTPPAAPSGLTATAVGSS 341

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 3468 SLHLSWT-VAQGPFESFVVqYRDT--DGQPRAVPVAADQHTVTIEDLEPGKKYKFLlyglvggkrlgpVSALGmTAPEED 3544
Cdd:COG3401    342 SITLSWTaSSDADVTGYNV-YRSTsgGGTYTKIAETVTTTSYTDTGLTPGTTYYYK------------VTAVD-AAGNES 407

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 3545 TPAPELASEAPEPPEEPRLGVLAVTDTAPDSMRLSWSVAQGPFDSFVVQYEDTNGQPQALLVDGDQSKILISGLEPSTPY 3624
Cdd:COG3401    408 APSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTA 487

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|
gi 1622934688 3625 RFLLYGLHEGKRLGPLSAEGTTGPAPAGQTSGEPGPRLSQLSVTDVTTSS 3674
Cdd:COG3401    488 NLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVT 537
fn3 pfam00041
Fibronectin type III domain;
3452-3519 2.40e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.43  E-value: 2.40e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934688 3452 PPPRlgELTVTEETSSSLHLSWT---VAQGPFESFVVQYRDTDGQ--PRAVPVAADQHTVTIEDLEPGKKYKF 3519
Cdd:pfam00041    1 SAPS--NLTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEV 71
fn3 pfam00041
Fibronectin type III domain;
1061-1141 2.64e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.43  E-value: 2.64e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 1061 GPPRlgELTVTDRTSDSLLLRWTVPE---GEFDSFVIQYKDRDGQ--PQVVPVEGPQRSAVITSLDPGRKYKFVLYGFVG 1135
Cdd:pfam00041    1 SAPS--NLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78


                   ....*.
gi 1622934688 1136 KKRHGP 1141
Cdd:pfam00041   79 GGEGPP 84
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1416-1695 3.59e-11

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 69.26  E-value: 3.59e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 1416 VRVGGEESEVTVGGLEPGHKYKMHLYGLHEGQRVGPVSAVGVTAPQqeeTPPAtkPPleprlGELTVTDVTPNSVGLSWT 1495
Cdd:COG3401    185 LTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPT---TPPS--AP-----TGLTATADTPGSVTLSWD 254

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 1496 -VPEGQFDSFMVqYKDKDGQPQAVPVAADQQ-EVTIYNLEPERKYkmnMYglhdgqRVgplSVV----IMTAPLPPAPAT 1569
Cdd:COG3401    255 pVTESDATGYRV-YRSNSGDGPFTKVATVTTtSYTDTGLTNGTTY---YY------RV---TAVdaagNESAPSNVVSVT 321

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 1570 EASEPPLEPRlgELTVTDVTPDSVGLSWT-VPEGEFDSFVVQYKDR-DGQPQVVPVAADQREVTIPGLEPSRKYKFLLFG 1647
Cdd:COG3401    322 TDLTPPAAPS--GLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSgGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTA 399

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1622934688 1648 IQDGKRRSPVSVEA---KTAARGDASPGAPPRLGELWVTDPTPDSLHLSWT 1695
Cdd:COG3401    400 VDAAGNESAPSEEVsatTASAASGESLTASVDAVPLTDVAGATAAASAASN 450
fn3 pfam00041
Fibronectin type III domain;
2195-2268 4.39e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.66  E-value: 4.39e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934688 2195 PRLGEMTVRDATPDSLSLSWTVPE---GQFDHFLVQYKNGDGQ--PKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGG 2268
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
1265-1342 5.60e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.28  E-value: 5.60e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 1265 GELTVTGVTPDSLRLSWT---VAQGPFDSFMVQYKDAQGQ--PQAVPVAGDENEVTVPGLDPDRKYKMNLYGLRGrQRVG 1339
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG-GGEG 82


                   ...
gi 1622934688 1340 PES 1342
Cdd:pfam00041   83 PPS 85
fn3 pfam00041
Fibronectin type III domain;
750-831 6.55e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.28  E-value: 6.55e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  750 PAIEGMRMHLLEETTVRTEWTPAP---GPVDAYEIQFIPTTEGaSPPFTARVPSSASAYDQRGLAPGQEYQVTVRALRGT 826
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSG-EPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*
gi 1622934688  827 SWGPP 831
Cdd:pfam00041   80 GEGPP 84
fn3 pfam00041
Fibronectin type III domain;
1578-1643 1.01e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 60.89  E-value: 1.01e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622934688 1578 PRLGELTVTDVTPDSVGLSWTVPE---GEFDSFVVQYKDRDGQ--PQVVPVAADQREVTIPGLEPSRKYKF 1643
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEV 71
fn3 pfam00041
Fibronectin type III domain;
843-919 1.27e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 60.51  E-value: 1.27e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  843 PQDLRVVAVTPTTLELGWLRP---QAEVDRFVVSYVSAGNQRVRLE--VPPEADGTLLTDLMPGVEYVVTVTAERGRAVS 917
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEitVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82


                   ..
gi 1622934688  918 YP 919
Cdd:pfam00041   83 PP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1159-1238 2.37e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 59.82  E-value: 2.37e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 1159 PPRLGNLWVTDPTPDSLHLSWTVPE---GQFDTFMVQYRDKDGRP--QVVPVEGPERSFVVSSLDPDHKYRFTLFGIaNK 1233
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAV-NG 79


                   ....*
gi 1622934688 1234 KRYGP 1238
Cdd:cd00063     80 GGESP 84
fn3 pfam00041
Fibronectin type III domain;
3360-3425 3.79e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.97  E-value: 3.79e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622934688 3360 PRLGELTVTDATPDSVGLSWTVPE---GEFDSFVVQYKDKDG--RLQVVPVAADQREVTVPGLEPSRKYKF 3425
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEV 71
fn3 pfam00041
Fibronectin type III domain;
3660-3742 8.78e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.20  E-value: 8.78e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 3660 PRLSQLSVTDVTTSSLRLNWEAPP---GAFDSFLLRFgvpSPSTLEPHPRpllqrELMVPGTRHSAVLRDLRPGTLYSLT 3736
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEY---RPKNSGEPWN-----EITVPGTTTSVTLTGLKPGTEYEVR 72


                   ....*.
gi 1622934688 3737 LYGLRG 3742
Cdd:pfam00041   73 VQAVNG 78
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1575-1663 1.43e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.89  E-value: 1.43e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 1575 PLEPRlgELTVTDVTPDSVGLSWTVPE---GEFDSFVVQYKDRDGQP--QVVPVAADQREVTIPGLEPSRKYKFLLFGIq 1649
Cdd:cd00063      1 PSPPT--NLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAV- 77

                           90
                   ....*....|....*.
gi 1622934688 1650 DGKRRSPVS--VEAKT 1663
Cdd:cd00063     78 NGGGESPPSesVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
2961-3028 1.55e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.42  E-value: 1.55e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934688 2961 TVTGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDG--RPQVVRVGGEESEVTVGGLEPGRKYKMHLYGLHEG 3028
Cdd:pfam00041    7 TVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2745-2812 1.55e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.42  E-value: 1.55e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934688 2745 TVTGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDG--RPQVVRVGGEESEVTVGGLEPGRKYKMHLYGLHEG 2812
Cdd:pfam00041    7 TVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2529-2596 1.55e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.42  E-value: 1.55e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934688 2529 TVTGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDG--RPQVVRVGGEESEVTVGGLEPGRKYKMHLYGLHEG 2596
Cdd:pfam00041    7 TVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
3177-3244 1.64e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.42  E-value: 1.64e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934688 3177 TVAGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDGQ--PQAVRVGGEESEVTVRGLEPGRKYKMHLYGLYEG 3244
Cdd:pfam00041    7 TVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1156-1227 1.98e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 56.85  E-value: 1.98e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622934688  1156 PGTPPrlgNLWVTDPTPDSLHLSWTVPE-----GQFDTFMVQYRDKDGRPQVVPVEGPERSFVVSSLDPDHKYRFTL 1227
Cdd:smart00060    1 PSPPS---NLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRV 74
fn3 pfam00041
Fibronectin type III domain;
1376-1446 2.07e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.04  E-value: 2.07e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934688 1376 GELTVTGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDG--RPQAVRVGGEESEVTVGGLEPGHKYKMHLYGLHEG 1446
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1062-1131 2.17e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.12  E-value: 2.17e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622934688 1062 PPRLGELTVTDRTSDSLLLRWTVPE---GEFDSFVIQYKDRDGQP--QVVPVEGPQRSAVITSLDPGRKYKFVLY 1131
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVR 75
fn3 pfam00041
Fibronectin type III domain;
1159-1240 3.38e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 56.27  E-value: 3.38e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 1159 PPRlgNLWVTDPTPDSLHLSWTVPE---GQFDTFMVQYRDKDG--RPQVVPVEGPERSFVVSSLDPDHKYRFTLFGIaNK 1233
Cdd:pfam00041    2 APS--NLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV-NG 78


                   ....*..
gi 1622934688 1234 KRYGPLT 1240
Cdd:pfam00041   79 GGEGPPS 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
763-948 3.55e-09

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 63.10  E-value: 3.55e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  763 TTVRTEWTPAPGP-VDAYEIQFIPTTEGaspPFTARVPSSASAYDQRGLAPGQEYQVTVRAL--RGTSWGPPASKTITTM 839
Cdd:COG3401    247 GSVTLSWDPVTESdATGYRVYRSNSGDG---PFTKVATVTTTSYTDTGLTNGTTYYYRVTAVdaAGNESAPSNVVSVTTD 323

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  840 I---DGPQDLRVVAVTPTTLELGW-LRPQAEVDRFVVsYVSAGNQRVRLEVPPEADGTLLTD--LMPGVEYVVTVTA--E 911
Cdd:COG3401    324 LtppAAPSGLTATAVGSSSITLSWtASSDADVTGYNV-YRSTSGGGTYTKIAETVTTTSYTDtgLTPGTTYYYKVTAvdA 402

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 1622934688  912 RGRAVSYPASVRANTGSSPSGllGTTDEPPPSGPSTT 948
Cdd:COG3401    403 AGNESAPSEEVSATTASAASG--ESLTASVDAVPLTD 437
fn3 pfam00041
Fibronectin type III domain;
1475-1555 5.19e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.88  E-value: 5.19e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 1475 PRLGELTVTDVTPNSVGLSWTVPE---GQFDSFMVQYKDKDGQ--PQAVPVAADQQEVTIYNLEPERKYKMNMYGLHdGQ 1549
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVN-GG 79


                   ....*.
gi 1622934688 1550 RVGPLS 1555
Cdd:pfam00041   80 GEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1061-1128 6.57e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 55.70  E-value: 6.57e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934688  1061 GPPRlgELTVTDRTSDSLLLRWTVPE-----GEFDSFVIQYKDRDGQPQVVPVEGPQRSAVITSLDPGRKYKF 1128
Cdd:smart00060    2 SPPS--NLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 3365-3425 6.79e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.97  E-value: 6.79e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934688 3365 LTVTDATPDSVGLSWTVPE---GEFDSFVVQYKDKDGR--LQVVPVAADQREVTVPGLEPSRKYKF 3425
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGdwKEVEVTPGSETSYTLTGLKPGTEYEF 72
fn3 pfam00041
Fibronectin type III domain;
2415-2485 7.44e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.50  E-value: 7.44e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934688 2415 GELTVTGSSPDSLSLSWTIP---QGRFDSFTVQYKDRDG--RPQVVRVGGEESEVTVGSLEPGNKYKMHLYGLHEG 2485
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 841-921 9.01e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.58  E-value: 9.01e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  841 DGPQDLRVVAVTPTTLELGWLRPQ---AEVDRFVVSYVSAGNQRVRLEVPPEADGT--LLTDLMPGVEYVVTVTAERGRA 915
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETsyTLTGLKPGTEYEFRVRAVNGGG 81


                   ....*.
gi 1622934688  916 VSYPAS 921
Cdd:cd00063     82 ESPPSE 87
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1575-1643 9.07e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.93  E-value: 9.07e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622934688  1575 PLEPRlgELTVTDVTPDSVGLSWTVPE-----GEFDSFVVQYKDRDGQPQVVPVAADQREVTIPGLEPSRKYKF 1643
Cdd:smart00060    1 PSPPS--NLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1223-1496 9.31e-09

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 61.56  E-value: 9.31e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 1223 YRFTLFGIANKKRYGP--LTADGTTAPErkeePPrpesleqpllGELTVTGVTPDSLRLSWT-VAQGPFDSFMVQYKDAQ 1299
Cdd:COG3401    207 YRVAATDTGGESAPSNevSVTTPTTPPS----AP----------TGLTATADTPGSVTLSWDpVTESDATGYRVYRSNSG 272

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 1300 GQPQAVPVAGDENEVTVPGLDPDRKYKmnlYGLRGRQRVGPESvvaktapqedvdeTPSPTELGTEAPEPSEEPLlgELT 1379
Cdd:COG3401    273 DGPFTKVATVTTTSYTDTGLTNGTTYY---YRVTAVDAAGNES-------------APSNVVSVTTDLTPPAAPS--GLT 334

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 1380 VTGSSPDSLSLSWT-VPQGRFDSFTVQYKDR-DGRPQAVRVGGEESEVTVGGLEPGHKYK-----MHLYGLhEGQRVGPV 1452
Cdd:COG3401    335 ATAVGSSSITLSWTaSSDADVTGYNVYRSTSgGGTYTKIAETVTTTSYTDTGLTPGTTYYykvtaVDAAGN-ESAPSEEV 413

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....
gi 1622934688 1453 SAVGVTAPQQEETPPATKPPLEPRLGELTVTDVTPNSVGLSWTV 1496
Cdd:COG3401    414 SATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAV 457
fn3 pfam00041
Fibronectin type III domain;
2102-2169 9.69e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.11  E-value: 9.69e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934688 2102 TVTGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDG--RPQVVRVGGEESEVTVGGLEPGNKYKMHLYGLHEG 2169
Cdd:pfam00041    7 TVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 3453-3519 1.11e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.20  E-value: 1.11e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622934688 3453 PPRLGELTVTEETSSSLHLSWTVAQ---GPFESFVVQYRDTDGQP--RAVPVAADQHTVTIEDLEPGKKYKF 3519
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEF 72
fn3 pfam00041
Fibronectin type III domain;
3270-3332 1.11e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 54.73  E-value: 1.11e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622934688 3270 GELTVAAVTSDSVGLSWT---VAQGPFDSFLVQYR--DTQGQPQAVPVSGDLRAVTVSGLDPARKYKF 3332
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRpkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEV 71
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 3452-3519 1.37e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.54  E-value: 1.37e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934688  3452 PPPRlgELTVTEETSSSLHLSWT-----VAQGPFESFVVQYRDTDGQPRAVPVAADQHTVTIEDLEPGKKYKF 3519
Cdd:smart00060    2 SPPS--NLRVTDVTSTSVTLSWEpppddGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2852-2932 2.06e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.42  E-value: 2.06e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 2852 LTVTDATPDSLSLSWTVPE---GQFDHFLVQYRNGDGQP--KAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGGQRVGPV 2926
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPS 86


                   ....*.
gi 1622934688 2927 SVIRVT 2932
Cdd:cd00063     87 ESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 3365-3425 2.32e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.77  E-value: 2.32e-08
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934688  3365 LTVTDATPDSVGLSWTVPE-----GEFDSFVVQYKDKDGRLQVVPVAADQREVTVPGLEPSRKYKF 3425
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 3762-3838 2.74e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.77  E-value: 2.74e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  3762 SPRDLQFSEIRETSAKVNWMPPPS-RADSFKVSYQLADGGEP---QSVQVDGRARTQKLQGLIPGARYEVTVVSVRGFEE 3837
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEPPPDdGITGYIVGYRVEYREEGsewKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGE 82


                    .
gi 1622934688  3838 S 3838
Cdd:smart00060   83 G 83
fn3 pfam00041
Fibronectin type III domain;
3566-3641 3.45e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.57  E-value: 3.45e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 3566 LAVTDTAPDSMRLSWS---VAQGPFDSFVVQYEDTNGQ--PQALLVDGDQSKILISGLEPSTPYRFLLYGLHeGKRLGPL 3640
Cdd:pfam00041    6 LTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVN-GGGEGPP 84


                   .
gi 1622934688 3641 S 3641
Cdd:pfam00041   85 S 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
2997-3234 3.64e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 59.63  E-value: 3.64e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 2997 VVRVGGEESEVTVGGLEPGRKYKMhlyglhegrRVGPVSAVGVTAPEDEAEATQavPTTTPEPPikprlGELTVTDATPD 3076
Cdd:COG3401    184 SLTVTSTTLVDGGGDIEPGTTYYY---------RVAATDTGGESAPSNEVSVTT--PTTPPSAP-----TGLTATADTPG 247

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 3077 SLSLSWT-VPEGQFDHFLVqYRNGDGQPKAVRVpGHEDGVTI--SGLEPDHKYK-----MNLYGFHGgqrvGPMSVIGVT 3148
Cdd:COG3401    248 SVTLSWDpVTESDATGYRV-YRSNSGDGPFTKV-ATVTTTSYtdTGLTNGTTYYyrvtaVDAAGNES----APSNVVSVT 321

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 3149 VAEEETPSPTepsteapeppeepllgELTVAGSSPDSLSLSWT-VPQGRFDSFTVQYKDR-DGQPQAVRVGGEESEVTVR 3226
Cdd:COG3401    322 TDLTPPAAPS----------------GLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSgGGTYTKIAETVTTTSYTDT 385


                   ....*...
gi 1622934688 3227 GLEPGRKY 3234
Cdd:COG3401    386 GLTPGTTY 393
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 841-914 4.33e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.00  E-value: 4.33e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934688   841 DGPQDLRVVAVTPTTLELGWLRPQAE-----VDRFVVSYVSAGNQRVRLEVPPEADGTLLTDLMPGVEYVVTVTAERGR 914
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2625-2706 4.78e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 53.27  E-value: 4.78e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 2625 PEPPikprlGELTVTDATPDSLSLSWTVPE---GQFDHFLVQYRNGDGQP--KAVRVPGHEDGVTISGLEPDHKYKMNLY 2699
Cdd:cd00063      1 PSPP-----TNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVR 75


                   ....*..
gi 1622934688 2700 GFHGGQR 2706
Cdd:cd00063     76 AVNGGGE 82
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 3057-3138 4.78e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 53.27  E-value: 4.78e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 3057 PEPPikprlGELTVTDATPDSLSLSWTVPE---GQFDHFLVQYRNGDGQP--KAVRVPGHEDGVTISGLEPDHKYKMNLY 3131
Cdd:cd00063      1 PSPP-----TNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVR 75


                   ....*..
gi 1622934688 3132 GFHGGQR 3138
Cdd:cd00063     76 AVNGGGE 82
fn3 pfam00041
Fibronectin type III domain;
1672-1739 4.95e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.19  E-value: 4.95e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622934688 1672 GAPPRLGelwVTDPTPDSLHLSWTVPE---GQFDSFVVQFKDKDGPQV---VPVEGHERSVTIAPLDAGRKYRF 1739
Cdd:pfam00041    1 SAPSNLT---VTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPwneITVPGTTTSVTLTGLKPGTEYEV 71
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1105-1397 6.50e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 58.86  E-value: 6.50e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 1105 VVPVEGPQRSAVITSLDPGRKYKFVLYGFVGKKRhGPLVTEAKILPQSDPrPGTPprlGNLWVTDPTPDSLHLSWT-VPE 1183
Cdd:COG3401    184 SLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGE-SAPSNEVSVTTPTTP-PSAP---TGLTATADTPGSVTLSWDpVTE 258

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 1184 GQFDTFMVqYRDKDGRPQVVPV-EGPERSFVVSSLDPDHKYRFTLFGIANKKRYGPL--TADGTTAPERkeePPRPESle 1260
Cdd:COG3401    259 SDATGYRV-YRSNSGDGPFTKVaTVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPsnVVSVTTDLTP---PAAPSG-- 332

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 1261 qpllgeLTVTGVTPDSLRLSWT-VAQGPFDSFMVQYKDAQ-GQPQAVPVAGDENEVTVPGLDPDRKYKmnlYGLRGRQRV 1338
Cdd:COG3401    333 ------LTATAVGSSSITLSWTaSSDADVTGYNVYRSTSGgGTYTKIAETVTTTSYTDTGLTPGTTYY---YKVTAVDAA 403

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934688 1339 GPESvvaktAPQEDVDETPSPTelgTEAPEPSEEPLLGELTVTGSSPDSLSLSWTVPQG 1397
Cdd:COG3401    404 GNES-----APSEEVSATTASA---ASGESLTASVDAVPLTDVAGATAAASAASNPGVS 454
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
2781-3082 8.61e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 58.48  E-value: 8.61e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 2781 VVRVGGEESEVTVGGLEPGRKYKMHLYGLHEGQRVGPVSAVGVTAPedeaettqaaptttPEPPIKPrlGELTVTDATPD 2860
Cdd:COG3401    184 SLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTP--------------TTPPSAP--TGLTATADTPG 247

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 2861 SLSLSWT-VPEGQFDHFLVqYRNGDGQPKAVRVpGHEDGVTI--SGLEPDHKYK-----MNLYGFHGGqrvgPVSVIRVT 2932
Cdd:COG3401    248 SVTLSWDpVTESDATGYRV-YRSNSGDGPFTKV-ATVTTTSYtdTGLTNGTTYYyrvtaVDAAGNESA----PSNVVSVT 321

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 2933 AAEEETPAPTEPsteapeppeepllgelTVTGSSPDSLSLSWT-VPQGRFDSFTVQYKDR-DGRPQVVRVGGEESEVTVG 3010
Cdd:COG3401    322 TDLTPPAAPSGL----------------TATAVGSSSITLSWTaSSDADVTGYNVYRSTSgGGTYTKIAETVTTTSYTDT 385

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622934688 3011 GLEPGRKYKmhlYglhegrRVGPVSAVGvtapeDEAEATQAVPTTTPEPPIKPRLGELTVTDATPDSLSLSW 3082
Cdd:COG3401    386 GLTPGTTYY---Y------KVTAVDAAG-----NESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATA 443
fn3 pfam00041
Fibronectin type III domain;
3939-4016 1.08e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 52.03  E-value: 1.08e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 3939 APRDLEAKEVTPRTALLTWTEPQVRP---TGYLLSFDTPGG--RTQEILLPGGVTSHQLLGLFPSTLYNARLQAMWGESL 4013
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPDGNgpiTGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81


                   ...
gi 1622934688 4014 LPP 4016
Cdd:pfam00041   82 GPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1993-2073 1.18e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.11  E-value: 1.18e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 1993 LTVTDATPDSLSLSWTVPE---GQFDHFLVQYRNGDGRP--KAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGGQRVGPV 2067
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPS 86


                   ....*.
gi 1622934688 2068 SAIGVT 2073
Cdd:cd00063     87 ESVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1378-1458 1.33e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.11  E-value: 1.33e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 1378 LTVTGSSPDSLSLSWTVPQ---GRFDSFTVQYKDRDGRP--QAVRVGGEESEVTVGGLEPGHKYKMHLYGLHEGQRVGPV 1452
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPS 86


                   ....*.
gi 1622934688 1453 SAVGVT 1458
Cdd:cd00063     87 ESVTVT 92
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
3818-4008 1.51e-07

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 57.70  E-value: 1.51e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 3818 GLIPGARYEVTVVSVRGFEESEPLTGFL----TTVPDGPTQLRALNLTEGFAVLHWKPPQNP-VDTYDVQVTAPGAPPLQ 3892
Cdd:COG3401    198 DIEPGTTYYYRVAATDTGGESAPSNEVSvttpTTPPSAPTGLTATADTPGSVTLSWDPVTESdATGYRVYRSNSGDGPFT 277

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 3893 AEAPGSAVDYPLHDLVLHTNYTATVRGLRGPNLTSPAS--ITFTTGLE---APRDLEAKEVTPRTALLTWTE-PQVRPTG 3966
Cdd:COG3401    278 KVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSnvVSVTTDLTppaAPSGLTATAVGSSSITLSWTAsSDADVTG 357

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 1622934688 3967 YLLSFDT-PGGRTQEILLPGGVTSHQLLGLFPSTLYNARLQAM 4008
Cdd:COG3401    358 YNVYRSTsGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAV 400
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1267-1347 1.71e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.73  E-value: 1.71e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 1267 LTVTGVTPDSLRLSWTVAQ---GPFDSFMVQYKDAQGQP--QAVPVAGDENEVTVPGLDPDRKYKMNLYGLRGRQRVGP- 1340
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPs 86


                   ....*..
gi 1622934688 1341 ESVVAKT 1347
Cdd:cd00063     87 ESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
2565-2802 1.85e-07

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 57.32  E-value: 1.85e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 2565 VVRVGGEESEVTVGGLEPGRKYKMhlyglhegqRLGPVSAVGVTAPEDEAEATQavPTTTPEPPikprlGELTVTDATPD 2644
Cdd:COG3401    184 SLTVTSTTLVDGGGDIEPGTTYYY---------RVAATDTGGESAPSNEVSVTT--PTTPPSAP-----TGLTATADTPG 247

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 2645 SLSLSWT-VPEGQFDHFLVqYRNGDGQPKAVRVpGHEDGVTI--SGLEPDHKYK-----MNLYGFHGgqrvGPMSVIGVT 2716
Cdd:COG3401    248 SVTLSWDpVTESDATGYRV-YRSNSGDGPFTKV-ATVTTTSYtdTGLTNGTTYYyrvtaVDAAGNES----APSNVVSVT 321

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 2717 AAEEETPSPTepsteapeppeepllgELTVTGSSPDSLSLSWT-VPQGRFDSFTVQYKDR-DGRPQVVRVGGEESEVTVG 2794
Cdd:COG3401    322 TDLTPPAAPS----------------GLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSgGGTYTKIAETVTTTSYTDT 385


                   ....*...
gi 1622934688 2795 GLEPGRKY 2802
Cdd:COG3401    386 GLTPGTTY 393
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2745-2824 2.08e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.73  E-value: 2.08e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 2745 TVTGSSPDSLSLSWTVPQ---GRFDSFTVQYKDRDGRP--QVVRVGGEESEVTVGGLEPGRKYKMHLYGLHEGQRVGPVS 2819
Cdd:cd00063      8 RVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSE 87


                   ....*
gi 1622934688 2820 AVGVT 2824
Cdd:cd00063     88 SVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2961-3040 2.34e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 2.34e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 2961 TVTGSSPDSLSLSWTVPQ---GRFDSFTVQYKDRDGRP--QVVRVGGEESEVTVGGLEPGRKYKMHLYGLHEGRRVGPVS 3035
Cdd:cd00063      8 RVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSE 87


                   ....*
gi 1622934688 3036 AVGVT 3040
Cdd:cd00063     88 SVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1773-1862 2.34e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 2.34e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 1773 PPKPRlgeELQVTSVTQNSVGLSWTVPE---GQFDSFVVQYKDRDGQP--QVVPVEGSLREVSVPGLDPAHRYKLLLYGL 1847
Cdd:cd00063      1 PSPPT---NLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                           90
                   ....*....|....*
gi 1622934688 1848 HSGKRVGPISAVVIT 1862
Cdd:cd00063     78 NGGGESPPSESVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 3938-4023 2.53e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 2.53e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 3938 EAPRDLEAKEVTPRTALLTWTEPQ---VRPTGYLLSF-DTPGGRTQEI-LLPGGVTSHQLLGLFPSTLYNARLQAM--WG 4010
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYrEKGSGDWKEVeVTPGSETSYTLTGLKPGTEYEFRVRAVngGG 81

                           90
                   ....*....|...
gi 1622934688 4011 ESlLPPVSTSFTT 4023
Cdd:cd00063     82 ES-PPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 750-838 2.63e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 2.63e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  750 PAIEGMRMHLLEETTVRTEWTPAP---GPVDAYEIQFIPTTEGASPPFTARVPSSASaYDQRGLAPGQEYQVTVRALRGT 826
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETS-YTLTGLKPGTEYEFRVRAVNGG 80

                           90
                   ....*....|...
gi 1622934688  827 SWGPPA-SKTITT 838
Cdd:cd00063     81 GESPPSeSVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2625-2699 2.74e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.08  E-value: 2.74e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  2625 PEPPikprlGELTVTDATPDSLSLSWTVPE-----GQFDHFLVQYRNGDGQPKAVRVPGHEDGVTISGLEPDHKYKMNLY 2699
Cdd:smart00060    1 PSPP-----SNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 3057-3131 2.74e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.08  E-value: 2.74e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  3057 PEPPikprlGELTVTDATPDSLSLSWTVPE-----GQFDHFLVQYRNGDGQPKAVRVPGHEDGVTISGLEPDHKYKMNLY 3131
Cdd:smart00060    1 PSPP-----SNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2102-2181 3.14e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.96  E-value: 3.14e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 2102 TVTGSSPDSLSLSWTVPQ---GRFDSFTVQYKDRDGRP--QVVRVGGEESEVTVGGLEPGNKYKMHLYGLHEGRRVGPVS 2176
Cdd:cd00063      8 RVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSE 87


                   ....*
gi 1622934688 2177 AVGVT 2181
Cdd:cd00063     88 SVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2309-2389 3.49e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.96  E-value: 3.49e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 2309 LTMTDATPDSLSLSWTVPE---GQFDHFLVQYKNGDGQP--KTTRVPGHEDRVTISGLEPDHKYKMNLYGFHGGQRVGPV 2383
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPS 86


                   ....*.
gi 1622934688 2384 SAIGVT 2389
Cdd:cd00063     87 ESVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1472-1560 3.89e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.96  E-value: 3.89e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 1472 PLEPRlgELTVTDVTPNSVGLSWTVPE---GQFDSFMVQYKDKDGQP--QAVPVAADQQEVTIYNLEPERKYKMNMYGLH 1546
Cdd:cd00063      1 PSPPT--NLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                           90
                   ....*....|....
gi 1622934688 1547 DGQRVGPLSVVIMT 1560
Cdd:cd00063     79 GGGESPPSESVTVT 92
fn3 pfam00041
Fibronectin type III domain;
1774-1857 4.59e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 50.49  E-value: 4.59e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 1774 PKPRlgeELQVTSVTQNSVGLSWTVPE---GQFDSFVVQYKDRDGQ--PQVVPVEGSLREVSVPGLDPAHRYKLLLYGlH 1848
Cdd:pfam00041    1 SAPS---NLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQA-V 76


                   ....*....
gi 1622934688 1849 SGKRVGPIS 1857
Cdd:pfam00041   77 NGGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1671-1739 5.64e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.19  E-value: 5.64e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622934688 1671 PGAPprlGELWVTDPTPDSLHLSWTVPE---GQFDSFVVQFKDKDGPQVVPVE---GHERSVTIAPLDAGRKYRF 1739
Cdd:cd00063      1 PSPP---TNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEvtpGSETSYTLTGLKPGTEYEF 72
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 3939-4007 5.77e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.92  E-value: 5.77e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622934688  3939 APRDLEAKEVTPRTALLTWTEPQVRP-----TGYLLSFDTPGGRTQEILLPGGVTSHQLLGLFPSTLYNARLQA 4007
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEPPPDDGitgyiVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 559-586 6.04e-07

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 48.45  E-value: 6.04e-07
                           10        20
                   ....*....|....*....|....*...
gi 1622934688  559 CPGGCRGRGQCIDGRCVCEDGYSGEDCS 586
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2188-2277 6.65e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.19  E-value: 6.65e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 2188 PDAPlvkprlGEMTVRDATPDSLSLSWTVPE---GQFDHFLVQYKNGDGQP--KAVRVPGHEDGVTISGLEPDHKYKMNL 2262
Cdd:cd00063      1 PSPP------TNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRV 74

                           90
                   ....*....|....*
gi 1622934688 2263 YGFHGGQRMGPVSAV 2277
Cdd:cd00063     75 RAVNGGGESPPSESV 89
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2529-2591 6.98e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.19  E-value: 6.98e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622934688 2529 TVTGSSPDSLSLSWTVPQ---GRFDSFTVQYKDRDGRP--QVVRVGGEESEVTVGGLEPGRKYKMHLY 2591
Cdd:cd00063      8 RVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2844-2915 8.04e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.54  E-value: 8.04e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622934688  2844 PIKPRlgELTVTDATPDSLSLSWTVPE-----GQFDHFLVQYRNGDGQPKAVRVPGHEDGVTISGLEPDHKYKMNLY 2915
Cdd:smart00060    1 PSPPS--NLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1378-1441 9.41e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.54  E-value: 9.41e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934688  1378 LTVTGSSPDSLSLSWTVPQ-----GRFDSFTVQYKDRDGRPQAVRVGGEESEVTVGGLEPGHKYKMHLY 1441
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1993-2056 9.78e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.54  E-value: 9.78e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934688  1993 LTVTDATPDSLSLSWTVPE-----GQFDHFLVQYRNGDGRPKAVRVPGHEDGVTISGLEPDHKYKMNLY 2056
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 311-337 9.95e-07

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 47.68  E-value: 9.95e-07
                           10        20
                   ....*....|....*....|....*..
gi 1622934688  311 CPRGCSQRGRCEDGRCVCDPGYTGEDC 337
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 249-275 9.95e-07

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 47.68  E-value: 9.95e-07
                           10        20
                   ....*....|....*....|....*..
gi 1622934688  249 CPRGCSQRGRCEDGRCVCDPGYTGEDC 275
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
PTZ00214 PTZ00214
high cysteine membrane protein Group 4; Provisional
 254-669 1.04e-06

high cysteine membrane protein Group 4; Provisional


Pssm-ID: 173479 [Multi-domain]  Cd Length: 800  Bit Score: 55.31  E-value: 1.04e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  254 SQRGRCEDGRCVCDPGYTGedcGMRSCPRGCSQRGRCENGRCvcNPGYTGEDCgvRSCPRGCSQrgrceDGRCVCDPGYT 333
Cdd:PTZ00214   341 SKNDDNNGDGYLCGDATNG---GVSGCATCGYNSGAVTCTRC--SAGYLGVDG--KSCSESCSG-----DTRGVCTKVAE 408

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  334 GEDCGTRSCRwdcgeggrcvdgrCVCWPGYTGEDCSTRTCPRDCrgrGRCEDGE---C-ICDTGYSGDDCGVRSCPGDCN 409
Cdd:PTZ00214   409 GSESTEVSCR-------------CVCKPTFYNSSGTCTPCTDSC---AVCKDGTptgCqQCSPGKILEFSIVSSESADCV 472

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  410 QRGRCEDGRCVCwpGYTgLDcGSRACPRDCRGRGRCENGVCVCNagySGEDCGVRSCPG----DCRGRGRCESGRCVCWP 485
Cdd:PTZ00214   473 DQCSVGSECAEC--GIT-ID-GSRYCTRCKDASTYPFNGVCIPN---TQRDAYCTSTANgactTCSGAAFLMNGGCYTTE 545

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  486 GYTGRDCGTRACPGDC----RGRGRCVDGRCV-CNP---GFTGEDCGS-RRCPGDC-------RGHGSCED-GVCVcDAG 548
Cdd:PTZ00214   546 HYPGSTICDKQSNGKCtttkKGYGISPDGKLLeCDPtclACTAPGPGRcTRCPSDKllkrasgAATGSCVDpGACV-DGY 624

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  549 YSGEDCSTRSCPGGCRGRG------QCIDGRCVCEDGYSgedcsvrrCPNDCSQHGVCQD---GVCICW------EAYVG 613
Cdd:PTZ00214   625 YADGDACLPCATPGCKTCGhasfctECAGELFVSLDGQS--------CLEECTGDKVVGEvsgGVRRCWcergflPALDR 696

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934688  614 EDCSIRT-CPSNCHGRGRCEE-GRCL-CDPGYTGPTCATRMCPADCRGRGRCVQGVCMC 669
Cdd:PTZ00214   697 SGCVLPTeCPPDMPSCAACDEsGRCLlCVTSGHNVQVDQRTCAEGCGARASSNQGVCMC 755
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2417-2497 1.14e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.42  E-value: 1.14e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 2417 LTVTGSSPDSLSLSWTIPQ---GRFDSFTVQYKDRDGRP--QVVRVGGEESEVTVGSLEPGNKYKMHLYGLHEGRRVGPV 2491
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPS 86


                   ....*.
gi 1622934688 2492 SAVGVT 2497
Cdd:cd00063     87 ESVTVT 92
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 373-399 1.14e-06

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 47.68  E-value: 1.14e-06
                           10        20
                   ....*....|....*....|....*..
gi 1622934688  373 CPRDCRGRGRCEDGECICDTGYSGDDC 399
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 3177-3253 1.44e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.03  E-value: 1.44e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 3177 TVAGSSPDSLSLSWTVPQ---GRFDSFTVQYKDRDGQP--QAVRVGGEESEVTVRGLEPGRKYKMHLYGLYEGRRVGPVS 3251
Cdd:cd00063      8 RVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSE 87


                   ..
gi 1622934688 3252 AV 3253
Cdd:cd00063     88 SV 89
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1267-1330 1.59e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.76  E-value: 1.59e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934688  1267 LTVTGVTPDSLRLSWT-----VAQGPFDSFMVQYKDAQGQPQAVPVAGDENEVTVPGLDPDRKYKMNLY 1330
Cdd:smart00060    7 LRVTDVTSTSVTLSWEpppddGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1068-1226 2.13e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 53.85  E-value: 2.13e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 1068 LTVTDRTSDSLLLRWT-VPEGEFDSFVIQYKDRDGQPQVVPVEGPQRSAVITSLDPGRKYKFVLYGFVGKKRHGPLVTEA 1146
Cdd:COG3401    239 LTATADTPGSVTLSWDpVTESDATGYRVYRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSNVV 318

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 1147 KILPQSDPrPGTPprlGNLWVTDPTPDSLHLSWT-VPEGQFDTFMVqYRDK--DGRPQVVPVEGPERSFVVSSLDPDHKY 1223
Cdd:COG3401    319 SVTTDLTP-PAAP---SGLTATAVGSSSITLSWTaSSDADVTGYNV-YRSTsgGGTYTKIAETVTTTSYTDTGLTPGTTY 393


                   ...
gi 1622934688 1224 RFT 1226
Cdd:COG3401    394 YYK 396
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2745-2807 2.29e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.38  E-value: 2.29e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622934688  2745 TVTGSSPDSLSLSWTVPQ-----GRFDSFTVQYKDRDGRPQVVRVGGEESEVTVGGLEPGRKYKMHLY 2807
Cdd:smart00060    8 RVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2961-3023 2.29e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.38  E-value: 2.29e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622934688  2961 TVTGSSPDSLSLSWTVPQ-----GRFDSFTVQYKDRDGRPQVVRVGGEESEVTVGGLEPGRKYKMHLY 3023
Cdd:smart00060    8 RVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2529-2591 2.29e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.38  E-value: 2.29e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622934688  2529 TVTGSSPDSLSLSWTVPQ-----GRFDSFTVQYKDRDGRPQVVRVGGEESEVTVGGLEPGRKYKMHLY 2591
Cdd:smart00060    8 RVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2309-2372 3.22e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.99  E-value: 3.22e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934688  2309 LTMTDATPDSLSLSWTVPE-----GQFDHFLVQYKNGDGQPKTTRVPGHEDRVTISGLEPDHKYKMNLY 2372
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 3663-3738 3.35e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.99  E-value: 3.35e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622934688  3663 SQLSVTDVTTSSLRLNWEAPPGA-FDSFLLRFgvpspsTLEPHPRPLLQRELMVPGTRHSAVLRDLRPGTLYSLTLY 3738
Cdd:smart00060    5 SNLRVTDVTSTSVTLSWEPPPDDgITGYIVGY------RVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2102-2164 3.35e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.99  E-value: 3.35e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622934688  2102 TVTGSSPDSLSLSWTVPQ-----GRFDSFTVQYKDRDGRPQVVRVGGEESEVTVGGLEPGNKYKMHLY 2164
Cdd:smart00060    8 RVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2188-2263 4.16e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.61  E-value: 4.16e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  2188 PDAPlvkprlGEMTVRDATPDSLSLSWTVPE-----GQFDHFLVQYKNGDGQPKAVRVPGHEDGVTISGLEPDHKYKMNL 2262
Cdd:smart00060    1 PSPP------SNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRV 74


                    .
gi 1622934688  2263 Y 2263
Cdd:smart00060   75 R 75
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
314-418 4.19e-06

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 49.37  E-value: 4.19e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  314 GCSQRG-RCEDGRCVC-----DPGYTGEDCGtrSCRWDCGEGGRCVDGRCVCWPGYT--GEDC-STRTCPRDCRGRGR-- 382
Cdd:NF041328    13 GCPEPGaVCPEGLSVCggacvDLRSDPSNCG--ACGVACGAGQTCVAGACGCGPGTVacGGACvDTASDPAHCGACGAac 90

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1622934688  383 -----CEDGEC--ICDTGYS--GDDC-GVRSCPGDCNQRG-RCEDGR 418
Cdd:NF041328    91 apgqvCEGGACreACSEGLTrcGGACvDLATDPLHCGACGvACDPGE 137
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1671-1739 4.68e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.61  E-value: 4.68e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622934688  1671 PGAPPRLgelWVTDPTPDSLHLSWTVPE-GQFDSFVVQFKDKDGP-----QVVPVEGHERSVTIAPLDAGRKYRF 1739
Cdd:smart00060    1 PSPPSNL---RVTDVTSTSVTLSWEPPPdDGITGYIVGYRVEYREegsewKEVNVTPSSTSYTLTGLKPGTEYEF 72
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 3566-3645 4.97e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 47.49  E-value: 4.97e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 3566 LAVTDTAPDSMRLSWSVAQ---GPFDSFVVQYEDTNGQP--QALLVDGDQSKILISGLEPSTPYRFLLYGLHEGKRlGPL 3640
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGE-SPP 85


                   ....*
gi 1622934688 3641 SAEGT 3645
Cdd:cd00063     86 SESVT 90
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1472-1539 5.16e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.22  E-value: 5.16e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934688  1472 PLEPRlgELTVTDVTPNSVGLSWTVPE-----GQFDSFMVQYKDKDGQPQAVPVAADQQEVTIYNLEPERKYK 1539
Cdd:smart00060    1 PSPPS--NLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYE 71
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2417-2480 5.86e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.22  E-value: 5.86e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934688  2417 LTVTGSSPDSLSLSWTIPQ-----GRFDSFTVQYKDRDGRPQVVRVGGEESEVTVGSLEPGNKYKMHLY 2480
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1773-1842 6.39e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.22  E-value: 6.39e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622934688  1773 PPKPRlgeELQVTSVTQNSVGLSWTVPE-----GQFDSFVVQYKDRDGQPQVVPVEGSLREVSVPGLDPAHRYKL 1842
Cdd:smart00060    1 PSPPS---NLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 3177-3244 7.78e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.84  E-value: 7.78e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934688  3177 TVAGSSPDSLSLSWTVPQ-----GRFDSFTVQYKDRDGQPQAVRVGGEESEVTVRGLEPGRKYKMHLYGLYEG 3244
Cdd:smart00060    8 RVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
594-703 9.38e-06

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 48.22  E-value: 9.38e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  594 CSQHG-VCQDGVCICWEAYVgedcSIRTCPSNCHGRG-------RCEEGRCLCDPGYT--GPTC-ATRMCPADCRGRGR- 661
Cdd:NF041328    14 CPEPGaVCPEGLSVCGGACV----DLRSDPSNCGACGvacgagqTCVAGACGCGPGTVacGGACvDTASDPAHCGACGAa 89

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1622934688  662 ------CVQGVCMCHVGYGGEDCGQ-------EEPPASACPGGCGPRELCQAGQC 703
Cdd:NF041328    90 capgqvCEGGACREACSEGLTRCGGacvdlatDPLHCGACGVACDPGESCRGGAC 144
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 3272-3352 1.23e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 46.72  E-value: 1.23e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 3272 LTVAAVTSDSVGLSWTVAQ---GPFDSFLVQYRDTQGQP--QAVPVSGDLRAVTVSGLDPARKYKFLLFGlQNGKRHGP- 3345
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRA-VNGGGESPp 85


                   ....*...
gi 1622934688 3346 -VPVEART 3352
Cdd:cd00063     86 sESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 3849-3935 1.44e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 46.34  E-value: 1.44e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 3849 PDGPTQLRALNLTEGFAVLHWKPPQN---PVDTYDVQVTAPGAPPLQ--AEAPGSAVDYPLHDLVLHTNYTATVRGLRGP 3923
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDdggPITGYVVEYREKGSGDWKevEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                           90
                   ....*....|...
gi 1622934688 3924 NLTSPA-SITFTT 3935
Cdd:cd00063     81 GESPPSeSVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 3566-3626 1.51e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.07  E-value: 1.51e-05
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934688  3566 LAVTDTAPDSMRLSWS-----VAQGPFDSFVVQYEDTNGQPQALLVDGDQSKILISGLEPSTPYRF 3626
Cdd:smart00060    7 LRVTDVTSTSVTLSWEpppddGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
2309-2510 1.52e-05

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 51.16  E-value: 1.52e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 2309 LTMTDATPDSLSLSWT-VPEGQFDHFLVQYKNGDGQPKTTRVPGHEDRVTISGLEPDHKYKmnlYGfhggqrvgpVSAIG 2387
Cdd:COG3401    239 LTATADTPGSVTLSWDpVTESDATGYRVYRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYY---YR---------VTAVD 306

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 2388 vTAAEEETPSPTEPSTEAPEPSEEPLlgELTVTGSSPDSLSLSWT-IPQGRFDSFTVQYKDR-DGRPQVVRVGGEESEVT 2465
Cdd:COG3401    307 -AAGNESAPSNVVSVTTDLTPPAAPS--GLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSgGGTYTKIAETVTTTSYT 383

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 1622934688 2466 VGSLEPGNKYK-----MHLYGLhEGRRVGPVSAVGVTAPREDVDETPSPT 2510
Cdd:COG3401    384 DTGLTPGTTYYykvtaVDAAGN-ESAPSEEVSATTASAASGESLTASVDA 432
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 3272-3332 1.72e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.68  E-value: 1.72e-05
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934688  3272 LTVAAVTSDSVGLSWT-----VAQGPFDSFLVQYRDTQGQPQAVPVSGDLRAVTVSGLDPARKYKF 3332
Cdd:smart00060    7 LRVTDVTSTSVTLSWEpppddGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 280-306 1.77e-05

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 44.21  E-value: 1.77e-05
                           10        20
                   ....*....|....*....|....*..
gi 1622934688  280 CPRGCSQRGRCENGRCVCNPGYTGEDC 306
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
fn3 pfam00041
Fibronectin type III domain;
3852-3922 3.10e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 45.10  E-value: 3.10e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934688 3852 PTQLRALNLTEGFAVLHWKPP---QNPVDTYDVQVTAPGAPPLQAE--APGSAVDYPLHDLVLHTNYTATVRGLRG 3922
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEitVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 3663-3738 3.57e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.18  E-value: 3.57e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934688 3663 SQLSVTDVTTSSLRLNWEAPP---GAFDSFLLRFGVPSPSTLEPHPRPllqrelmvPGTRHSAVLRDLRPGTLYSLTLY 3738
Cdd:cd00063      5 TNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVT--------PGSETSYTLTGLKPGTEYEFRVR 75
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 528-555 6.41e-05

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 42.67  E-value: 6.41e-05
                           10        20
                   ....*....|....*....|....*...
gi 1622934688  528 CPGDCRGHGSCEDGVCVCDAGYSGEDCS 555
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 625-647 6.75e-05

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 42.33  E-value: 6.75e-05
                           10        20
                   ....*....|....*....|....*
gi 1622934688  625 CHGRGRCE--EGRCLCDPGYTGPTC 647
Cdd:pfam07974    2 CSGRGTCVnqCGKCVCDSGYQGATC 26
fn3 pfam00041
Fibronectin type III domain;
1885-1955 6.92e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 44.33  E-value: 6.92e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934688 1885 GELTVEEATPHTLHLSWM---VTEGEFDSFEI--QHTDREGQLQTVRTGGDRNDITLSGLESDHRYLVTLYGFHDG 1955
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTpppDGNGPITGYEVeyRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
PTZ00214 PTZ00214
high cysteine membrane protein Group 4; Provisional
 266-577 1.12e-04

high cysteine membrane protein Group 4; Provisional


Pssm-ID: 173479 [Multi-domain]  Cd Length: 800  Bit Score: 48.37  E-value: 1.12e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  266 CDPGYTGEDCgmRSCPRGCS--QRGRCE-----------NGRCVCNPGYTGEDCGVRSCPRGCSQrgrCEDGR---C-VC 328
Cdd:PTZ00214   379 CSAGYLGVDG--KSCSESCSgdTRGVCTkvaegsestevSCRCVCKPTFYNSSGTCTPCTDSCAV---CKDGTptgCqQC 453

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  329 DPGYTGE---------DCGTR-SCRWDCGEGGRCVDG-----RC----------VCWPGyTGED--CSTR---TCPRdCR 378
Cdd:PTZ00214   454 SPGKILEfsivssesaDCVDQcSVGSECAECGITIDGsryctRCkdastypfngVCIPN-TQRDayCTSTangACTT-CS 531

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  379 GRGRCEDGECICDTGYSGDDCGVRSCPGDCNQR----GRCEDGRCV-CWPgyTGLDCGSRA------CPRDC---RGRGr 444
Cdd:PTZ00214   532 GAAFLMNGGCYTTEHYPGSTICDKQSNGKCTTTkkgyGISPDGKLLeCDP--TCLACTAPGpgrctrCPSDKllkRASG- 608

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  445 CENGVCV----CNAGY--SGEDCGVRSCPGdCRGRGrcESGRCVCWPGYTGRDCGTRACPGDCRGR---GRCVDG--RCV 513
Cdd:PTZ00214   609 AATGSCVdpgaCVDGYyaDGDACLPCATPG-CKTCG--HASFCTECAGELFVSLDGQSCLEECTGDkvvGEVSGGvrRCW 685

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622934688  514 CNPGF-----TGEDCGSRRCPGDCRGHGSC-EDGVCV-CDAGYSGEDCSTRSCPGGCRGRGQCIDGRCVCE 577
Cdd:PTZ00214   686 CERGFlpaldRSGCVLPTECPPDMPSCAACdESGRCLlCVTSGHNVQVDQRTCAEGCGARASSNQGVCMCE 756
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 497-523 1.30e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 41.90  E-value: 1.30e-04
                           10        20
                   ....*....|....*....|....*..
gi 1622934688  497 CPGDCRGRGRCVDGRCVCNPGFTGEDC 523
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 500-523 1.68e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 41.18  E-value: 1.68e-04
                           10        20
                   ....*....|....*....|....*.
gi 1622934688  500 DCRGRGRCVD--GRCVCNPGFTGEDC 523
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 590-617 1.83e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 41.13  E-value: 1.83e-04
                           10        20
                   ....*....|....*....|....*...
gi 1622934688  590 CPNDCSQHGVCQDGVCICWEAYVGEDCS 617
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 3849-3918 1.89e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.99  E-value: 1.89e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622934688  3849 PDGPTQLRALNLTEGFAVLHWKPPQNP-----VDTYDVQVTAPGAPPLQAEAPGSAVDYPLHDLVLHTNYTATVR 3918
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 469-492 2.21e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.79  E-value: 2.21e-04
                           10        20
                   ....*....|....*....|....*.
gi 1622934688  469 DCRGRGRCES--GRCVCWPGYTGRDC 492
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 531-554 2.32e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.79  E-value: 2.32e-04
                           10        20
                   ....*....|....*....|....*.
gi 1622934688  531 DCRGHGSCED--GVCVCDAGYSGEDC 554
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 221-244 3.05e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.41  E-value: 3.05e-04
                           10        20
                   ....*....|....*....|....*.
gi 1622934688  221 DCQGRGRCVQ--GVCVCRAGFSGPDC 244
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 750-829 3.08e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.22  E-value: 3.08e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688   750 PAIEGMRMHLLEETTVRTEWTPAPGP-VDAYEIQFIPTTEGASPPF-TARVPSSASAYDQRGLAPGQEYQVTVRALRGTS 827
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgITGYIVGYRVEYREEGSEWkEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1622934688   828 WG 829
Cdd:smart00060   82 EG 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1449-1817 3.14e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 46.92  E-value: 3.14e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 1449 VGPVSAVGVTAPQQEETPPATKPPLEPRLGELTVTDVTPNSVGLSWTVPEGQFDSFMVQYKDKDGQPQAVPVAADQQEVT 1528
Cdd:COG3401     43 VLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAV 122

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 1529 IYNLEPERKYKMNMYGLHDGQRVGPLSVVIMTAPLPPAPATEASEPPLEPRLGELTVTDVTPDSVGLSWTVPEGefdsfv 1608
Cdd:COG3401    123 GTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGG------ 196

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 1609 vqykdrdgqpqvvpvaadqrevtiPGLEPSRKYKFLLFGIQDGKRRSP---VSVEAKTAArgdasPGAPprlGELWVTDP 1685
Cdd:COG3401    197 ------------------------GDIEPGTTYYYRVAATDTGGESAPsneVSVTTPTTP-----PSAP---TGLTATAD 244

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 1686 TPDSLHLSWT-VPEGQFDSFVV-QFKDKDGPQVVPVEGHERSVTIAPLDAGRKYRFLLYGLlgkkrhgplTADGTTEARS 1763
Cdd:COG3401    245 TPGSVTLSWDpVTESDATGYRVyRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAV---------DAAGNESAPS 315

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622934688 1764 AMDD--TGTKRPPKPrlgEELQVTSVTQNSVGLSWT-VPEGQFDSFVVQYKDRDGQP 1817
Cdd:COG3401    316 NVVSvtTDLTPPAAP---SGLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSGGGT 369
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 284-306 3.15e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.41  E-value: 3.15e-04
                           10        20
                   ....*....|....*....|....*
gi 1622934688  284 CSQRGRCEN--GRCVCNPGYTGEDC 306
Cdd:pfam07974    2 CSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 563-585 3.83e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.41  E-value: 3.83e-04
                           10        20
                   ....*....|....*....|....*
gi 1622934688  563 CRGRGQCID--GRCVCEDGYSGEDC 585
Cdd:pfam07974    2 CSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 438-461 3.87e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.41  E-value: 3.87e-04
                           10        20
                   ....*....|....*....|....*.
gi 1622934688  438 DCRGRGRCEN--GVCVCNAGYSGEDC 461
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 315-337 3.94e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.41  E-value: 3.94e-04
                           10        20
                   ....*....|....*....|....*
gi 1622934688  315 CSQRGRCED--GRCVCDPGYTGEDC 337
Cdd:pfam07974    2 CSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 253-275 3.94e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.41  E-value: 3.94e-04
                           10        20
                   ....*....|....*....|....*
gi 1622934688  253 CSQRGRCED--GRCVCDPGYTGEDC 275
Cdd:pfam07974    2 CSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 376-399 4.18e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.02  E-value: 4.18e-04
                           10        20
                   ....*....|....*....|....*.
gi 1622934688  376 DCRGRGRCED--GECICDTGYSGDDC 399
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 435-461 5.18e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 39.97  E-value: 5.18e-04
                           10        20
                   ....*....|....*....|....*..
gi 1622934688  435 CPRDCRGRGRCENGVCVCNAGYSGEDC 461
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
279-414 5.42e-04

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 43.21  E-value: 5.42e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  279 SCPRGCSqrgRCeNGRCVCNPGyTGEDCGvrSCPRGCSQRGRCEDGRCVCDPGytGEDCG-----TRSCRWDCGE-GGRC 352
Cdd:NF041328    20 VCPEGLS---VC-GGACVDLRS-DPSNCG--ACGVACGAGQTCVAGACGCGPG--TVACGgacvdTASDPAHCGAcGAAC 90

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622934688  353 VDGRcVCWPGYTGEDCSTrtcprdcrGRGRCeDGECI---CDTGYSGdDCGVRSCPGDCNQRGRC 414
Cdd:NF041328    91 APGQ-VCEGGACREACSE--------GLTRC-GGACVdlaTDPLHCG-ACGVACDPGESCRGGAC 144
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 719-745 5.50e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 39.97  E-value: 5.50e-04
                           10        20
                   ....*....|....*....|....*..
gi 1622934688  719 CPGDCRGRGECHDGSCICKDGYAGEDC 745
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1887-1950 5.82e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 41.45  E-value: 5.82e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934688  1887 LTVEEATPHTLHLSWM-----VTEGEFDSFEIQHTDREGQLQTVRTGGDRNDITLSGLESDHRYLVTLY 1950
Cdd:smart00060    7 LRVTDVTSTSVTLSWEpppddGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
191-295 6.19e-04

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 43.21  E-value: 6.19e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  191 CNDQGRCVRGRCVCFPGYTgpSCGwpscpgdcqgrGRCVQ--------GVC--VCRAGFSgpdCSQRSCPRGCSQ-RGRC 259
Cdd:NF041328    49 CGAGQTCVAGACGCGPGTV--ACG-----------GACVDtasdpahcGACgaACAPGQV---CEGGACREACSEgLTRC 112

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1622934688  260 eDGRCV---CDPGYTGEdCGmRSCPRGCSqrgrCENGRC 295
Cdd:NF041328   113 -GGACVdlaTDPLHCGA-CG-VACDPGES----CRGGAC 144
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 190-213 6.56e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 39.64  E-value: 6.56e-04
                           10        20
                   ....*....|....*....|....*.
gi 1622934688  190 DCNDQGRCVR--GRCVCFPGYTGPSC 213
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
492-590 8.01e-04

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 42.82  E-value: 8.01e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  492 CGtrACPGDCRGRGRCVDGRCVCNPGFT--GEDCGSRR--------CPGDCRGHGSCEDGVC--VCDAGYsgEDCStRSC 559
Cdd:NF041328    42 CG--ACGVACGAGQTCVAGACGCGPGTVacGGACVDTAsdpahcgaCGAACAPGQVCEGGACreACSEGL--TRCG-GAC 116

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1622934688  560 PGGCRGRGQCidGRC--VCEDgysGEDCSVRRC 590
Cdd:NF041328   117 VDLATDPLHC--GACgvACDP---GESCRGGAC 144
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 407-430 8.73e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 39.25  E-value: 8.73e-04
                           10        20
                   ....*....|....*....|....*.
gi 1622934688  407 DCNQRGRCED--GRCVCWPGYTGLDC 430
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 218-245 9.34e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 39.20  E-value: 9.34e-04
                           10        20
                   ....*....|....*....|....*...
gi 1622934688  218 CPGDCQGRGRCVQGVCVCRAGFSGPDCS 245
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
416-543 1.23e-03

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 42.05  E-value: 1.23e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  416 DGRCVCWPGyTGLDCGsrACPRDCRGRGRCENGVCVCNAGysGEDCG-----VRSCPGDCrgrGRCESgrcVCWPGYTgr 490
Cdd:NF041328    29 GGACVDLRS-DPSNCG--ACGVACGAGQTCVAGACGCGPG--TVACGgacvdTASDPAHC---GACGA---ACAPGQV-- 95

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1622934688  491 dCGTRACPGDC-RGRGRCvDGRCVcNPGFTGEDCGSrrCPGDCRGHGSCEDGVC 543
Cdd:NF041328    96 -CEGGACREACsEGLTRC-GGACV-DLATDPLHCGA--CGVACDPGESCRGGAC 144
dnaA PRK14086
chromosomal replication initiator protein DnaA;
884-1212 1.35e-03

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 44.82  E-value: 1.35e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  884 LEVPPE-ADGTLLTDLMPGVEYvvTVTAERGRAVSYPASVRANTGSSPsgllgttdePPPSGPSTTQGAQAPLLQQRPQE 962
Cdd:PRK14086    51 LAVPNEfAKEVLEGRLAPIISE--TLSRELGRPIRIAITVDPSAGEPA---------PPPPHARRTSEPELPRPGRRPYE 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  963 lgelrVLGRDETGRLRVVWTAQPdtfahfQLRLRVPEGPGAHEEVLPGDVrqalvPPPAPGAPYELSLRGVPPGGKPSDP 1042
Cdd:PRK14086   120 -----GYGGPRADDRPPGLPRQD------QLPTARPAYPAYQQRPEPGAW-----PRAADDYGWQQQRLGFPPRAPYASP 183

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 1043 VIYQGIMDKDEEKPG--KSSGPPRLGEltvtdrtsdslllrWTVPEGEFDsfviqYKDRDGQPQVVPVEGPQrsavitsl 1120
Cdd:PRK14086   184 ASYAPEQERDREPYDagRPEYDQRRRD--------------YDHPRPDWD-----RPRRDRTDRPEPPPGAG-------- 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 1121 dpgrkykfvlygfvGKKRHGPLVTEAKILPQSDPRPGTPPRLGNLWVTDPTPDSLHLSWTvPEGQFDTFMVQYRDKDGRP 1200
Cdd:PRK14086   237 --------------HVHRGGPGPPERDDAPVVPIRPSAPGPLAAQPAPAPGPGEPTARLN-PKYTFDTFVIGASNRFAHA 301

                          330
                   ....*....|...
gi 1622934688 1201 QVVPV-EGPERSF 1212
Cdd:PRK14086   302 AAVAVaEAPAKAY 314
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1993-2191 1.44e-03

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 44.61  E-value: 1.44e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 1993 LTVTDATPDSLSLSWT-VPEGQFDHFLVQYRN-GDGRPKAV-RVPGHEdgVTISGLEPDHKYK-----MNLYGFHGgqrv 2064
Cdd:COG3401    239 LTATADTPGSVTLSWDpVTESDATGYRVYRSNsGDGPFTKVaTVTTTS--YTDTGLTNGTTYYyrvtaVDAAGNES---- 312

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 2065 GPVSAIGVTAAEEETPSPTepsteapeppeepllgELTVTGSSPDSLSLSWT-VPQGRFDSFTVQYKDR-DGRPQVVRVG 2142
Cdd:COG3401    313 APSNVVSVTTDLTPPAAPS----------------GLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSgGGTYTKIAET 376

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1622934688 2143 GEESEVTVGGLEPGNKYK-----MHLYGLhEGRRVGPVSAVGVTAPKEESPDAP 2191
Cdd:COG3401    377 VTTTSYTDTGLTPGTTYYykvtaVDAAGN-ESAPSEEVSATTASAASGESLTAS 429
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
3497-3685 1.72e-03

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 44.61  E-value: 1.72e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 3497 VPVAADQHTVTIEDLEPGKKYKFLLYGLVGGKRLGPVSALGMTAPEEDTPAPElaseapeppeeprlgVLAVTDTAPDSM 3576
Cdd:COG3401    185 LTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPT---------------GLTATADTPGSV 249

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688 3577 RLSWS-VAQGPFDSFVVQYEDTNGQPQALLVDGDQSKILISGLEPSTPYRFLLYGLHEGKRLGPLS--AEGTTGPAPAGQ 3653
Cdd:COG3401    250 TLSWDpVTESDATGYRVYRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSnvVSVTTDLTPPAA 329

                          170       180       190
                   ....*....|....*....|....*....|..
gi 1622934688 3654 TSGepgprlsqLSVTDVTTSSLRLNWEAPPGA 3685
Cdd:COG3401    330 PSG--------LTATAVGSSSITLSWTASSDA 353
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 4059-4073 1.79e-03

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 38.70  E-value: 1.79e-03
                           10
                   ....*....|....*
gi 1622934688 4059 PLNVFCDMETDGGGW 4073
Cdd:NF040941    29 PFQVYCDMTTDGGGW 43
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1887-1955 2.15e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 40.17  E-value: 2.15e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622934688 1887 LTVEEATPHTLHLSWMV---TEGEFDSFEIQHTDR-EGQLQTVRTG-GDRNDITLSGLESDHRYLVTLYGFHDG 1955
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPpedDGGPITGYVVEYREKgSGDWKEVEVTpGSETSYTLTGLKPGTEYEFRVRAVNGG 80
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 345-368 2.95e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 37.71  E-value: 2.95e-03
                           10        20
                   ....*....|....*....|....*.
gi 1622934688  345 DCGEGGRCVD--GRCVCWPGYTGEDC 368
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 652-678 3.01e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 38.05  E-value: 3.01e-03
                           10        20
                   ....*....|....*....|....*..
gi 1622934688  652 CPADCRGRGRCVQGVCMCHVGYGGEDC 678
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 621-648 3.28e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 37.66  E-value: 3.28e-03
                           10        20
                   ....*....|....*....|....*...
gi 1622934688  621 CPSNCHGRGRCEEGRCLCDPGYTGPTCA 648
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 404-430 5.32e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 37.28  E-value: 5.32e-03
                           10        20
                   ....*....|....*....|....*..
gi 1622934688  404 CPGDCNQRGRCEDGRCVCWPGYTGLDC 430
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EB pfam01683
EB module; This domain has no known function. It is found in several C. elegans proteins. The ...
 599-643 5.67e-03

EB module; This domain has no known function. It is found in several C. elegans proteins. The domain contains 8 conserved cysteines that probably form four disulphide bridges. This domain is found associated with kunitz domains pfam00014.


Pssm-ID: 460294  Cd Length: 52  Bit Score: 37.79  E-value: 5.67e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1622934688  599 VCQDGVCIcWEAYVGEDCSIrtcPSNCHGRGRCEEGRCLCDPGYT 643
Cdd:pfam01683    6 VLVNGQCV-PKVAPGESCEA---DEQCPGGSVCVNGVCQCPPGFT 46
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 342-369 7.36e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 36.89  E-value: 7.36e-03
                           10        20
                   ....*....|....*....|....*...
gi 1622934688  342 CRWDCGEGGRCVDGRCVCWPGYTGEDCS 369
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 191-348 8.53e-03

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 40.16  E-value: 8.53e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934688  191 CNDQGRCvrGRCVCFPGYTGPSCGWPSCPGDCQGRGRCVQGVCvCRAgFSGPDCSQRSCPRGCSQRGRCEDGRCVCDPGY 270
Cdd:pfam01500   14 CSTGGTC--GSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSC-CRP-TCQPCCQTSCCQPTCCQTSSCQTGCGGIGYGQ 89

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622934688  271 TGEDCGMRSCPRGCSQRGRCENgrcVCNPGYtgedCGVRSCPRGCSQRGRCEdGRCvCDPGYTGEDCGTRSCRWDCGE 348
Cdd:pfam01500   90 EGSSGAVSSRTRWCRPDCRVEG---TCLPPC----CVVSCTPPTCCQLHHAQ-ASC-CRPSYCGQSCCRPACCCQCSE 158
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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