|
Name |
Accession |
Description |
Interval |
E-value |
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
3-466 |
0e+00 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 622.53 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 3 MDNQLPRKKVPGFCSFRYGLSFLVHCCNVITTAQRTCLNLTMVVMVNSTDPHGLPNTSTKKLLDNIKNPVYNWSPDIQGI 82
Cdd:TIGR00894 1 MENVFASTKLPYFCSFRLFLSFLLHICNVIIIAQRICLSLTMVAMVNKENSTDLACLSAENELDNIKNPNFKWSGALQGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 83 ILSSTFYGFVIIQVPVGYFSGIYSTKKMIGFALCLSSVLSLLIPPAAGIGVAWVIVCRAVQGAAQGIVGTAQFEIYVKWA 162
Cdd:TIGR00894 81 ILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGSVSPATHKIIVKWA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 163 PPLERGRLTSMSTSGFLLGPFIVLLVTGVICES-LGWPMVFYIFGACGCALCLLWFILFYDDPKDHPCISISEKEYITSS 241
Cdd:TIGR00894 161 PPKERSRLLGMSTSGFQLGTFIFLPISGWLCESwGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKYINSS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 242 LVQQVSSSRQSLPIKAMLKSLPVWAISIGSFTFFWSHIIMTLYTPLFINSTLRVNIKENGFLSSLPYLFAWICGNLVGQL 321
Cdd:TIGR00894 241 LQGQKGSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAGYL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 322 SDFFLTRNILSVIAVRKLFTAAGFLLPAIFGVCLPHLSSSFYGIVIFLILVSATGSFCLGGVLINGLDIAPRYFGFIKAC 401
Cdd:TIGR00894 321 ADFLKSSKTLSLTAARKIFNGIGGLGPGIFAYALPYLSAAFYLTIIILTLANAVSSGPLAGVLINSLDLAPRFLGFIKGI 400
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966937424 402 STLSGMLGGLIASTLTGLILRQDPESAWFKTFILMAAINVTGLIFYLIVAKAEIQDWAKERQHTR 466
Cdd:TIGR00894 401 TGLPGFIGGLIASTLAGNILSQDSKNVWLIVFLIMAFVNILCVIFYLIFGSAERQDWAKEEKDTR 465
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
23-451 |
3.52e-145 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 420.10 E-value: 3.52e-145
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 23 SFLVHCCNVITTAQRTCLNLTMVVMVNSTDPHGLPNTSTKKLLDNIKNPVYNWSPDIQGIILSSTFYGFVIIQVPVGYFS 102
Cdd:cd17318 1 AILLFLGFAVVYAMRVNLSVAIVAMVNSTATHDNNNTSTDKDTLPVEAPEFDWSEKTQGIILSSFFYGYILTQIPGGYLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 103 GIYSTKKMIGFALCLSSVLSLLIPPAAGIGVAWVIVCRAVQGAAQGIVGTAQFEIYVKWAPPLERGRLTSMSTSGFLLGP 182
Cdd:cd17318 81 EKYGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 183 FIVLLVTGVICESLGWPMVFYIFGACGCALCLLWFILfyddpkdhpcisisekeyitsslvqqvsssrqslpikamlkSL 262
Cdd:cd17318 161 VIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFL-----------------------------------------VL 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 263 PVWAISIGSFTFFWSHIIMTLYTPLFINSTLRVNIKENGFLSSLPYLFAWICGNLVGQLSDFFLTRNILSVIAVRKLFTA 342
Cdd:cd17318 200 PVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGILSTTTVRKLFTS 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 343 AGFLLPAIFGVCLPHLSSSFYGIVIFLILVSATGSFCLGGVLINGLDIAPRYFGFIKACSTLSGMLGGLIASTLTGLILR 422
Cdd:cd17318 280 IGFLGPGVFLIALGYLGSNATLAVVFLTLSVGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATIAGIISPLIVGAIVK 359
|
410 420 430
....*....|....*....|....*....|
gi 966937424 423 QD-PESAWFKTFILMAAINVTGLIFYLIVA 451
Cdd:cd17318 360 NDqTIGQWRIVFFISAAIYILGAIFYLIFG 389
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
35-451 |
4.52e-81 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 256.25 E-value: 4.52e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 35 AQRTCLNLTMVVMVNSTDPHGLPNTS--------TKKLLDNIKNPVYNWSPDIQGIILSSTFYGFVIIQVPVGYFSGIYS 106
Cdd:cd17381 14 ALRVNLSVALVDMVNSNSTLPSNNSSnacpehssSPSVEHNETGKKYDWDAETQGWILGSFFYGYIITQIPGGYLASKIG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 107 TKKMIGFALCLSSVLSLLIPPAAGIGVAWVIVCRAVQGAAQGIVGTAQFEIYVKWAPPLERGRLTSMSTSGFLLGPFIVL 186
Cdd:cd17381 94 GKLLLGFGILGTAVFTLLTPLAADLGAGYLIAVRALEGLGEGVTFPAMHAMWASWAPPLERSRLLTISYAGAQLGTVVSL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 187 LVTGVICESLGWPMVFYIFGACGCALCLLWFILfyddpkdhpcisisekeyitsslvqqvsssrqslpikamlkSLPVWA 266
Cdd:cd17381 174 PLSGLICYYLDWTYVFYIFGAVGLLWFFLWIWL-----------------------------------------VMPLWA 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 267 ISIGSFTFFWSHIIMTLYTPLFINSTLRVNIKENGFLSSLPYLFAWICGNLVGQLSDFFLTRNILSVIAVRKLFTAAGFL 346
Cdd:cd17381 213 IVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLFMILSGQIADNLREKQNFSTVCVRKIFTLIGMI 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 347 LPAIFGVCLPHLSSSFYGIVIFLILVSATGSFCLGGVLINGLDIAPRY----FGFIKACSTLSGMLGGLIASTLTglilR 422
Cdd:cd17381 293 GPAVFLLAAGFTGCNYSLAVAFLTISSTLGGFSASGFNINHLDIAPSYagilLGITNTFATIPGMVGPVIAKSLT----H 368
|
410 420
....*....|....*....|....*....
gi 966937424 423 QDPESAWFKTFILMAAINVTGLIFYLIVA 451
Cdd:cd17381 369 NNTVEEWQTVFYISAAINVFGAIFFTIFG 397
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
58-451 |
2.47e-57 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 194.10 E-value: 2.47e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 58 NTSTKKLLDNIKNPVYNWSPDIQGIILSSTFYGFVIIQVPVGYFSGIYSTKKMIGFALCLSSVLSLLIPPAAGIGVAWVI 137
Cdd:cd17382 29 FTDAYGGKVIVHKAEFNWTPETVGLIESSFFWGYLVTQIPGGFIAAKFAANRVFGLAIFVTSTLNMLIPIAARVHYGCVI 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 138 VCRAVQGAAQGIVGTAQFEIYVKWAPPLERGRLTSMSTSGFLLGPFIVLLVTGVICESLGWPMVFYIFGACGCalclLWF 217
Cdd:cd17382 109 FVRILQGLVEGVTYPACHGIWRKWAPPLERSRLATTAFCGSYAGAVVGMPLSGILVQYVGWSSPFYVYGVFGI----IWY 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 218 ILFyddpkdhpcisisekeyitsslvqqvsssrqslpikaMLKSLPVWAISIGSFTFFWSHIIMTLYTPLFINSTLRVNI 297
Cdd:cd17382 185 MFW-------------------------------------MLVSMPVYAIIVANFCRSWTFYLLLISQPAYFKEVFGFDI 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 298 KENGFLSSLPYLFAWICGNLVGQLSDFFLTRNILSVIAVRKLFTAAGFLLPAIFGVCLPHLSSsfYGIVIFLILVSATGS 377
Cdd:cd17382 228 SKVGILSALPHLVMTIIVPIGGQLADYLRSRGILSTTAVRKIFNCGGFGMEATFLLVVAFSHS--PTVAISFLVLAVGFS 305
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966937424 378 -FCLGGVLINGLDIAPRYFGFIKACSTLSGMLGGLIASTLTGLILRQDPESAWFKTFILMAAINVTGLIFYLIVA 451
Cdd:cd17382 306 gFAISGFNVNHLDIAPRYASILMGISNGIGTLSGMVCPVIVGALTKHKTREEWQYVFLIASLVHFFGVIFYAIFA 380
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
73-451 |
8.52e-57 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 192.00 E-value: 8.52e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 73 YNWSPDIQGIILSSTFYGFVIIQVPVGYFSGIYSTKKMIGFALCLSSVLSLLIPPAAGIGVAWVIVCRAVQGAAQGIVGT 152
Cdd:cd17380 29 FGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSLPLLILSRILLGLGEGVHFP 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 153 AQFEIYVKWAPPLERGRLTSMSTSGFLLGPFIVLLVTGVICESLGWPMVFYIFGACGCALCLLWFILFyddpkdhpcisi 232
Cdd:cd17380 109 SMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALVWLIYL------------ 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 233 sekeyitsslvqqvsssrqslpikamlksLPVWAISIGSFTFFWSHIIMTLYTPLFINSTLrVNIKENGFLSSLPYLFAW 312
Cdd:cd17380 177 -----------------------------PPVWAIIVAHFCMNWGFYILLSWLPTYFHEVL-VPLAKGWVFNVVPWLVMF 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 313 ICGNLVGQLSDFFLTRNIlSVIAVRKLFTAAGFLLPAIFGVCLPHLSSsFYGIVIFLILVSATGSFCLGGVLINGLDIAP 392
Cdd:cd17380 227 PSSNVAGWLADHLISRGW-TVTSVRKLMQSIGFLGPALFLLLLSHTDS-FSLALLCMSVALGLSAFSSSGVLVNHQDIAP 304
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966937424 393 RY----FGFIKACSTLSGMLGGLiastLTGLILrqDPESAWFKTFILMAAINVTGLIFYLIVA 451
Cdd:cd17380 305 NYagivFGISNTAGTIPGIVGVY----LTGYIL--EATGSWSLVFVLAAVVNLVGAVVFLLFG 361
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
74-450 |
3.22e-26 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 109.20 E-value: 3.22e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 74 NWSPDIQGIILSSTFYGFVIIQVPVGYFSGIYSTKKMIGFALCLSSVLSLLIppAAGIGVAWVIVCRAVQGAAQGIVGTA 153
Cdd:cd17319 34 GLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALT--GFATSLTSLYVLRFLLGVAEAGFFPG 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 154 QFEIYVKWAPPLERGRLTSMSTSGFLLGPFIVLLVTGVICESLGWPMVFYIFGACGCALCLLWFILFYDdpkdhpcisis 233
Cdd:cd17319 112 AIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQ----------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 234 ekeyitsslvqqvsssrqslpikamlkslpVWAISIGSFTFFWSHIIMTLYTPLFINSTLRVNIKENGFLSSLPYLFAWI 313
Cdd:cd17319 181 ------------------------------VWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAI 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 314 CGNLVGQLSDFFLTRNilsviavRKLFTAAGFLLpAIFGVCLPHLSSSFYGIVIFLILVSATGSFCLGGVLINGLDIAPR 393
Cdd:cd17319 231 GMILGGRLSDRLLRGA-------RRLVIIIGLLL-AAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPG 302
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966937424 394 -----YFGFIKACstlsGMLGGLIASTLTGLILrqDPESAWFKTFILMAAINVTGLIFYLIV 450
Cdd:cd17319 303 eaaatAGGLINSG----GNLGGFVAPLLIGYLV--DATGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
73-452 |
4.55e-25 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 105.72 E-value: 4.55e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 73 YNWSPDIQGIILSSTFYGFVIIQVPVGYFSGIYSTKKMIGFALCLSSVLSLLIppAAGIGVAWVIVCRAVQGAAQGIVGT 152
Cdd:COG2271 40 LGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLF--GFATSFWQLLLLRFLLGLGEAGFFP 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 153 AQFEIYVKWAPPLERGRLTSMSTSGFLLGPFIVLLVTGVICESLGWPMVFYIFGacgcALCLLWFIlfyddpkdhpcisi 232
Cdd:COG2271 118 AALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILG----LPGLLLAL-------------- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 233 sekeyitsslvqqvsssrqslpikamlksLPVWAISIGSFTFFWSHIIMTLYTPLFINSTLRVNIKENGFLSSLPYLFAW 312
Cdd:COG2271 180 -----------------------------LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGI 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 313 ICGNLVGQLSDFFLTRnilsviavRKLFTAAGFLLpAIFGVCLPHLSSSFYGIVIFLILVSATGSFCLGGVLINGLDIAP 392
Cdd:COG2271 231 VGSLLGGWLSDRLGRR--------RKLVLAIGLLL-AALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFP 301
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 966937424 393 -RYFGFIKACSTLSGMLGGLIASTLTGLILRQdpeSAWFKTFILMAAINVTGLIFYLIVAK 452
Cdd:COG2271 302 kKARGTASGLVNTFGFLGGALGPLLVGYLLDA---TGYQAAFLLLAALALLAALLALLLLR 359
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
73-409 |
1.57e-21 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 95.18 E-value: 1.57e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 73 YNWSPDIQGIILSSTFYGFVIIQVPVGYFSGIYSTKKMIGFALCLSSVLSLLIppAAGIGVAWVIVCRAVQGAAQGIVGT 152
Cdd:pfam07690 27 LGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLL--LFASSLWLLLVLRVLQGLGAGALFP 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 153 AQFEIYVKWAPPLERGRLTSMSTSGFLLGPFIVLLVTGVICESLGWPMVFYIFGAcGCALCLLWFILFYDDPKDHPCISI 232
Cdd:pfam07690 105 AALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI-LSLLAAVLLLLPRPPPESKRPKPA 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 233 SEKEYITSslvqqvsssrqsLPIKAMLKSLPVWAIsIGSFTFFWSHIIMTLYTPLFINsTLRVNIKENGFLSSLPYLFAW 312
Cdd:pfam07690 184 EEARLSLI------------VAWKALLRDPVLWLL-LALLLFGFAFFGLLTYLPLYQE-VLGLSALLAGLLLGLGGLLGA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 313 ICGNLVGQLSDFFLTRnilsviavRKLFTAAGFLLPAIFGVCLPHLSSSFYGIVIFLILVSATGSFCLGGVLINGLDIAP 392
Cdd:pfam07690 250 IGRLLLGRLSDRLGRR--------RRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAP 321
|
330 340
....*....|....*....|..
gi 966937424 393 -----RYFGFIKACSTLSGMLG 409
Cdd:pfam07690 322 keergTASGLYNTAGSLGGALG 343
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
72-448 |
2.05e-19 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 89.79 E-value: 2.05e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 72 VYNWSPDIQGIILSSTFYGFVIIQVPVGYFSGIYSTKKMIGFALCLSSVLSLLIppAAGIGVAWVIVCRAVQGAAQGIVG 151
Cdd:cd06174 25 SFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLF--AFAPSFWLLLLGRFLLGLGSGLID 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 152 TAQFEIYVKWAPPLERGRLTSMSTSGFLLGPFIVLLVTGVICESL--GWPMVFYIFGAcgcaLCLLWFILFYDDPKDHPC 229
Cdd:cd06174 103 PAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLgfGWRAVFLIAAA----LALLAAILLLLVVPDPPE 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 230 ISISEKEYITSSlvqqvsssRQSLPIKAMLKSLPVWAISIGSFTFFWSHIIMTLYTPLFINSTLRVNIKENGFLSSLPYL 309
Cdd:cd06174 179 SARAKNEEASSK--------SVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 310 FAWICGNLVGQLSDFFLTRNILSVIavrklftaaGFLLPAIFGVCLPHLSSSFYGIVIFLILVSATGSFCLGGVLINGLD 389
Cdd:cd06174 251 AGALGSLLLGLLSDRLIGRKPLLLI---------GLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAEL 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 966937424 390 IAPRYFGFIKACSTLSGMLGGLIASTLTGLILRQDPesAWFKTFILMAAINVTGLIFYL 448
Cdd:cd06174 322 FPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATF--GLTGAFLVLAVLLLLAAILLL 378
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
73-450 |
2.57e-19 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 89.55 E-value: 2.57e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 73 YNWSPDIQGIILSSTFYGFVIIQVPVGYFSGIYSTKKMIGFALCLSsvlsllIPPAAGIGVA----WVIVCRAVQGAAQG 148
Cdd:COG2223 35 FGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL------GIGLLLLALAvsywLLLLLGLLLGIGGG 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 149 ---IVGTAQFeiyVKWAPPLERGRLTSMSTSGFLLGPFIVLLVTGVICESLGWPMVFYIFGACGCALCLLWFILFYDDPK 225
Cdd:COG2223 109 gsfAVGIALV---SKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPA 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 226 DHPcisisekeyitsslvqqvSSSRQSL-PIKAMLKSLPVWAISIGSFTFFWSHIIMTLYTPLFINSTLRVNIKENGFLS 304
Cdd:COG2223 186 GAA------------------AAAKASLrDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLA 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 305 SLPYLFAWICGNLVGQLSDFFLTRNILSVIavrklftaagFLLPAIFGVCLPHLSSSFYGIVIFLILVsatgSFCLGGVL 384
Cdd:COG2223 248 ALFALLGALGRPLGGWLSDRIGGRRVLLIV----------FALMALGLLLLALALGSLWLFLVLFLLL----GLALGGGN 313
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966937424 385 INGLDIAPRYFGfIKACSTLSGM------LGGLIASTLTGLILrqDPESAWFKTFILMAAINVTGLIFYLIV 450
Cdd:COG2223 314 GAVFALVPDIFP-TKNAGAVYGLvgaaggLGGFLGPLLFGALL--DATGSYTAAFLVFAVLALVALVLTLLL 382
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
73-392 |
4.19e-16 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 79.25 E-value: 4.19e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 73 YNWSPDIQGIILSSTFYGFVIIQVPVGYFSGIYSTKKMIGFALCLSSVLSLLIPPAAGIGvaWVIVCRAVQGAAQGIVGT 152
Cdd:COG2814 40 LGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLW--LLLAARFLQGLGAGALFP 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 153 AQFEIYVKWAPPLERGRLTSMSTSGFLLGPFIVLLVTGVICESLGWPMVFYIFGACGcALCLLWFILFYDDPKDHPcisi 232
Cdd:COG2814 118 AALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLA-LLALLLLLRLLPESRPAA---- 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 233 sekeyitsslvqqvsSSRQSLPIKAMLKSLPVWAISIGSFTFFWSHIIMTLYTPLFINSTLRVNIKENGFLSSLPYLFAW 312
Cdd:COG2814 193 ---------------RARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGV 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 313 ICGNLVGQLSDFFLTRNILSVIAvrkLFTAAGFLLPAifgvclphLSSSFYGIVIFLILVSATGSFCLGGVLINGLDIAP 392
Cdd:COG2814 258 LGALLAGRLADRFGRRRLLLIGL---LLLALGLLLLA--------LAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAP 326
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
81-449 |
6.46e-15 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 76.08 E-value: 6.46e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 81 GIILSSTFYGFVIIQVPVGYFSGIYSTKKMIGFALCLSSVLSLLIPPAAGigVAWVIVCRAVQGAAQGIVGTAQFEIYVK 160
Cdd:cd17325 34 GLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATS--YWQLLLARFLQGLASAAVWPAAMALIAD 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 161 WAPPLERGRLTSMSTSGFLLGPFIVLLVTGVICESLGWPMVFYIFGACGcALCLLWFILFYDDPKdhpcisisekeyiTS 240
Cdd:cd17325 112 IAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA-LLALVLALLLLPEPR-------------PP 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 241 SLVQQVSSSRQSLPIKAMLKSLPVWAISIGSFTFFWSHIIMTLYTPLFINSTLRVNIKENGFLSSLPYLFAWICGNLVGQ 320
Cdd:cd17325 178 PNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGK 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 321 LSDFFltrnilsviaVRKLFTAAGFLLPAIFGVCLPhLSSSFYGIVIFLILVSATGSFCLGGVLINGLDIAPR-----YF 395
Cdd:cd17325 258 LSDRI----------GRKPLILIGLLLSAVALLLLP-LATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPegrgtAM 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 966937424 396 GFIKACSTLSGMLGGLIASTLTGLIlrqdpesAWFKTFILMAAINVTGLIFYLI 449
Cdd:cd17325 327 GLFNTAFSLGMVLGPLLGGFLYDAF-------GFATPFLAAAALLLLAAVLFLL 373
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
81-439 |
3.01e-10 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 61.80 E-value: 3.01e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 81 GIILSSTFYGFVIIQVPVGYFSGIYSTKKMIGFALCLSSVLSLLIPPAAGIgvAWVIVCRAVQGAAQGIVGTAQFEIYVK 160
Cdd:cd17324 37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSF--ALLLLARALAGLAHGGFWAIAAAYAAD 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 161 WAPPLERGRLTSMSTSGFLLGPFIVLLVTGVICESLGWPMVFYIFGACGCALCLLWFILFYDDPKDHPcisisekeyits 240
Cdd:cd17324 115 LVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKP------------ 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 241 slvqqvSSSRQSLPIKAMLKSLPVWAISIGSFTFFWSHIIMTLYTPLFINSTLRVNIKENGFLSSLPYLFAWICGNLVGQ 320
Cdd:cd17324 183 ------GSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGR 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 321 LSDFFLTRNILsviavrklftaAGFLLPAIFGVCLPHLSSSFYGIVIFLILVSATGSFCLGGVLINGLDIAPRYFGFIKA 400
Cdd:cd17324 257 LADRGGRRALL-----------IALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASS 325
|
330 340 350
....*....|....*....|....*....|....*....
gi 966937424 401 CSTLSGMLGGLIASTLTGLILRQDPESAWFKTFILMAAI 439
Cdd:cd17324 326 LYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLL 364
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
81-446 |
3.57e-10 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 61.49 E-value: 3.57e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 81 GIILSSTFYGFVIIQVPVGYFSGIYSTKKMIGFALCLSSVLSLLIppAAGIGVAWVIVCRAVQGAAQGIVGTAQFEIYVK 160
Cdd:cd17475 34 GLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLM--ALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMR 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 161 WAPPLERGRLTSMSTSGFLLGPFIVLLVTGVICESLGWPMVFYIFGAcGCALCLLWFILFYDDPKDHPCISISEKEYITS 240
Cdd:cd17475 112 WFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGL-VSILAAVLFWLFYREPPAASAATESASTLLRS 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 241 slvqqvsssrqslpIKAMLKSLPVWAISIGSFTFFWSHIIMTLYTPLFINSTLRVNIKENGFLSSLpylfAWICGNL--- 317
Cdd:cd17475 191 --------------LKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAV----AQLGGALgri 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 318 -VGQLSDFFLTRNILSVIAVRKLFTAAGFllpAIFGVCLPHLSSSFYGIVIFLILVSATGSFCLGGVLINglDIAPRYF- 395
Cdd:cd17475 253 gLGRVSDRVFGGRRRPVLVITAAIAAAAL---LVLSLLSPGTPLWLLVLLLILLGLFAIGWNGLYLTLVA--ESAGPEQa 327
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 966937424 396 GFIKACSTLSGMLGGLIASTLTGLILRQ--DPESAWfktFILMAAINVTGLIF 446
Cdd:cd17475 328 GTALGLANTINFIGIAIGPPLFGLLVDAthSYAPAW---LALALLLVLAALLL 377
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
81-421 |
4.74e-10 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 61.24 E-value: 4.74e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 81 GIILSSTFYGFVIIQVPVGYFSGIYSTKKMIGFALCLSSvlsllippAAGIGVAWV------IVCRAVQGAAQGIVGTAQ 154
Cdd:TIGR00881 33 GLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCA--------IVNLFFGFStslwvmAALWALNGIFQGMGWPPC 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 155 FEIYVKWAPPLERGRLTSM-STSGFLLGPFIVLLVTGVICESLGWPMVFYIFGACGCALCLLWFILFYDDPKDhPCISIS 233
Cdd:TIGR00881 105 GRTVTKWFSRSERGTWVSFwNCSHNVGGGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVSLICFLLLRDSPQS-CGLPPA 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 234 EKEYITSSLVQQVSSSRQSLPIKA----MLKSLPVWAISIGSFTFFWSHIIMTLYTPLFINSTLRVNIKENGFLSSLPYL 309
Cdd:TIGR00881 184 EEMPNEEPDGDAEKKEEELTKKQIflqyVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYEL 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 310 FAWICGNLVGQLSDFFLTRNILSViavrKLFTAAGFLLPAIFGVCLPHLSSSFYGIVIFLILVSATGSFCLGGVLINGLd 389
Cdd:TIGR00881 264 GGLVGTLLAGWLSDKLFNGRRGPL----AVFFMALIIVSLLVYWLNPAANPLMDLICLFALGFLVYGPQMLIGVIASEL- 338
|
330 340 350
....*....|....*....|....*....|....*...
gi 966937424 390 iapryfGFIKACSTLSGM------LGGLIASTLTGLIL 421
Cdd:TIGR00881 339 ------APKKAAGTAAGFvgffayLGGILAGLPLGYLA 370
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
76-295 |
2.36e-07 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 52.12 E-value: 2.36e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 76 SPDIQGIILSSTFYGFVIIQVPVGYFSGIYSTKKMIGFALCLSSVLSLLIppAAGIGVAWVIVCRAVQGAAQGIVGTAQF 155
Cdd:COG0477 47 SSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLC--GLAPSPELLIAARALQGIGAGGLMPGAL 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 156 EIYVKWAPPLERGRLTSMSTSGFLLGPFIVLLVTGVICESLGWPMVFYIfgacGCALCLLWFILFYDDPKDHPCISISEK 235
Cdd:COG0477 125 ALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLI----NAPLGLLALVLRLRLPESRGLLLALLA 200
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 236 EYITSSLVQQVSSSRQSLPIKAMLKSLPVWAISIGSFTFFWSHIIMTLYTPLFINSTLRV 295
Cdd:COG0477 201 LALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLA 260
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
134-450 |
4.06e-05 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 45.73 E-value: 4.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 134 AWVI-VCRAVQGAAQGIVGTAQFEIYVKWAPPLERGRLTSMSTSGFLLGPFIVLLVTGVICESLGWPMVFYIFGACGCAL 212
Cdd:cd17312 91 LWFFaVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVV 170
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 213 CLLWFILFYDDPKdhpcisisekeyitsslvqqvsssrqslpikamlkslPVWAISIGSFTFFWSHIIMTLYTPLFINST 292
Cdd:cd17312 171 AIILFFFLRDSPP-------------------------------------YVWVLSLAYAFVYIVRYACLDWGPLYLYEV 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 293 LRVNIKENGFLSSLpYLFAWICGNLV-GQLSD--FFLTRNILSVIavrklftaagFLLPAIFGVCLPHLS-SSFYGIVIF 368
Cdd:cd17312 214 KGYSLIDAGWFSSL-YEVGGIAGTILaGLLSDklFGGRRAPIAVI----------YMLLMTLSLALFWFFpHNKLLSIVL 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 369 LILVsatgsfclgGVLINGLD-----IAPRYFGFIKACSTLSGMLGGL--IASTLTGLILRQ-DPESAWFKTFILMAAIN 440
Cdd:cd17312 283 LFLI---------GFFVGGPInliggAAAQDIGRKEAAGTATGFVGLFgyLGASLAGLPLGYiIDHYGWSTVFYFLISAA 353
|
330
....*....|
gi 966937424 441 VTGLIFYLIV 450
Cdd:cd17312 354 LLSVLLLLSL 363
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
135-450 |
4.62e-05 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 45.25 E-value: 4.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 135 WVIVCRAVQGAAQGIVGTAQFEIYVKWAPPLERGRLTSMSTSGF----LLGPFIvllvTGVICESLGWPMVFYIfgacgc 210
Cdd:cd17502 85 MLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFgiasVAGPLI----GGAFTDHLSWRWCFYI------ 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 211 alcllwfilfyddpkdhpcisisekeyitsslvqqvsssrqSLPIK----AMLKSlpVWAISIGSFTFFWSHIIMTLYTP 286
Cdd:cd17502 155 -----------------------------------------NLPIGglalALLRT--ILLSSIFGFLFGGALFGLIYYLP 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 287 LFINSTLRVNIKENGFLsSLPYLFAWICGNLVGQLsdffltrnILSVIAVRKLFTAAGFLLPAI--FGVCLPHLSSSFYG 364
Cdd:cd17502 192 LYFQLVLGDSATKSGVR-LLPLIIGLVIGSIISGA--------LISKTGRYKPLIVIGTILMSVgaGLLTTLTLDTSKWL 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 365 IVIFLILVSATGSFCLGGVLING-LDIAPRYFGFIKACSTLSGMLGGLIASTLTglilrqdpesawfKTFILMAAINVTG 443
Cdd:cd17502 263 LIGYLILLGLGLGIGFQQPLVAVqNAVPPADVGVATATNTFFRSLGGTLGVAIT-------------DVFLVALALAALA 329
|
....*..
gi 966937424 444 LIFYLIV 450
Cdd:cd17502 330 FLLSLFL 336
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
73-439 |
7.88e-05 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 44.62 E-value: 7.88e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 73 YNWSPDIQGIILSSTFYGFVIIQVPVGYFSGIYSTKKMIGFALCLSSVLSLLIPPAAGIGVawVIVCRAVQGAAQGIVGT 152
Cdd:cd17333 26 FNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYL--FVVLMFLAGLGAGILDT 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 153 AQfEIYVKWAPPLERGRLTSMSTSGFLLGPFIV-LLVTGVICESLGWPMVFYIFGACGCALCLLWFILFYDDPKDHPCis 231
Cdd:cd17333 104 GA-NTFVGALFEESSATRLNVLHGFFGLGALIGpLIATSLLTSELSWSWAYLIIGLIYLLLAILILLTLFPELPSARN-- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 232 isekeyitsslvQQVSSSRQSLPIKAMLKSLPVWAISIGSFTFFWSHIIMTLYTPLFINSTLRVNIKENGFLSSlpylFA 311
Cdd:cd17333 181 ------------PQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLS----GF 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 312 WICgnlvgqlsdFFLTRNILSVIAVRKLFTAagFLLPAIFGVCLPHLSSSFYGIVIFLILVSATGSFCLGGVLINGLDIA 391
Cdd:cd17333 245 WVG---------ITIGRLLGGPISRRIKPHT--LLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLG 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 966937424 392 PRYFGFIKACST----LSGMLGGLIASTLTGLILRQDPESAWFKTFILMAAI 439
Cdd:cd17333 314 ISNLPYAKGKGTsvllAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAI 365
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
132-457 |
1.10e-04 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 44.48 E-value: 1.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 132 GVAWVIVCRAVQGAAQGIVGTAqFEIYVKWAPPLERGRLTSMSTSGFLLGPFIVLLVTGVICESLGWPMVFYIFGACGCA 211
Cdd:COG2807 105 SVALLLAGTALIGAGIAVGNVL-LPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALL 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 212 LCLLWFILFYDDPKDHPcisisekeyitsslvqqvsSSRQSLPIKAMLKSLPVWAISIGSFTFFWSHIIMTLYTPLFINS 291
Cdd:COG2807 184 ALLLWLPLLRRRPAAAA-------------------AAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD 244
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 292 tLRVNIKENGFLSSLPYLFAWICGNLVGQLSDFFLTRNILSVIAVrkLFTAAGFLLPAIFGVCLPHLSSSFYGIviflil 371
Cdd:COG2807 245 -AGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLG--LLGLAGLLGLLLAPGSLPWLWAVLLGL------ 315
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 372 vSATGSFCLGGVLINgldiapRYFGFIKACSTLSGM------LGGLIASTLTGLIlrQDPESAWFKTFILMAAINVTGLI 445
Cdd:COG2807 316 -GQGGLFPLALTLIG------LRARTPAEAAALSGMaqsvgyLLAALGPLLVGAL--HDATGSWTAALLLLAALAVLMLV 386
|
330
....*....|..
gi 966937424 446 FYLIVAKAEIQD 457
Cdd:COG2807 387 AGLLAGRPYVED 398
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
166-421 |
1.71e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 43.74 E-value: 1.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 166 ERGRLTSMSTSGFLLGPFIVLLVTGVI------CESLGWPMVFYIFGACGcALCLLWFILFYDDPKDHPCISISEKEYit 239
Cdd:COG2211 144 ERTRLSSWRFAFAGLGGLLASVLPPPLvaafggDAALGYRLTALIFAVLG-LLAFLLTFFGTKERPVPEEEKVSLKES-- 220
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 240 sslvqqvsssrqslpIKAMLKSLPVWAISIGSFTFFWSHIIMTLYTPLFINSTLRVNIKENGFLSSLPYLFAWICGNLVG 319
Cdd:COG2211 221 ---------------LKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWP 285
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 320 QLSDFFLTRNILSVIAvrkLFTAAGFLLPAIFGvclphlSSSFYGIVIFLILVsatgSFCLGGVLINGL----DIAP--- 392
Cdd:COG2211 286 RLAKRFGKKKAFIIGL---LLAALGLLLLFFLG------PGNLWLLLVLAALA----GIGLGAILVLPWamlaDVVDyde 352
|
250 260 270
....*....|....*....|....*....|....
gi 966937424 393 -----RYFGFIKACSTLSGMLGGLIASTLTGLIL 421
Cdd:COG2211 353 wktgrRREGLYFGIFTFAIKLGQALAGALAGLLL 386
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
72-221 |
1.96e-04 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 43.33 E-value: 1.96e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 72 VYNWSPDIQGIILSSTFYGFVIIQVPVGYFSGIYSTKKMIGFALCLSSVLSLLIPPAAGIgvAWVIVCRAVQGAAQGIVG 151
Cdd:cd17325 229 LGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSF--WLLLLLLALLGLGLGLVF 306
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966937424 152 TAQFEIYVKWAPPLERGR----LTSMSTSGFLLGPfivlLVTGVICESLGWPMVFYiFGACGCALCLLWFILFY 221
Cdd:cd17325 307 PATLALLADIVPPEGRGTamglFNTAFSLGMVLGP----LLGGFLYDAFGFATPFL-AAAALLLLAAVLFLLLR 375
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
142-446 |
2.95e-04 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 43.09 E-value: 2.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 142 VQGAAQGIVGTAQFEIYVKWAPPLERGRL-----TSMSTSGfLLGPFIvllvTGVICESLGWPMVFYIFGACGCALCLLW 216
Cdd:cd17343 100 LNGLAQGLGWPPCAKILRKWFSPSQFGTWwsvlsTSMNLAG-SLGPIL----ATLLALSYGWRSTLSISGTVAVVMSVVC 174
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 217 FILFYDDPKDHPCISISEKEyitsSLVQQVSSSRQSLPIKAMLKSLPVWAISIGSFTFF--------WSH--IIMTLYTP 286
Cdd:cd17343 175 LLFIKNEPSDVGLNNIEEEE----SKGKKKKSPRGESTLKELLLSPFLWLLSLGYLVVFgvktavtdWGQlfLIQDKGQS 250
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 287 LFINSTLRVNIKENGFLSSLpylfawicgnLVGQLSDFFLTRNILSVIAVRKLFTAAGFllpaIFGVCL----------P 356
Cdd:cd17343 251 ALTGSSFMSSLEVGGFVGSI----------AAGYLSDWAVAKHGSSSRGNPRMPLALVF----MAGLTVslhlfrvhitS 316
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 357 HLSSSFYGIVIFLILVSATGSFCLGGVLINglDIAPRYF-GFIKACSTLSGMLGGLIASTLTGLILRQdpeSAWFKTFIL 435
Cdd:cd17343 317 DSSELFILLLGFLIGFSLYGPIAIFGVIAN--ESAPSHLcGTSHAIVALAANVGGVLAGLPFSYIAKH---YDWRTAFLL 391
|
330
....*....|....
gi 966937424 436 M---AAINVTGLIF 446
Cdd:cd17343 392 LeilCAITVVILFL 405
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
72-219 |
5.45e-04 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 42.17 E-value: 5.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 72 VYNWSPDIQGIILSSTFYGFVIIQVPVGYFSGI-YSTKKMIGFALCLSSVLSLLIPPAAGIgvAWVIVCRAVQGAAQGIV 150
Cdd:cd17474 228 LYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKrFGARRILVIGLLLYALSLLLLGFVPSL--ALLLIAIVLFGLGLGLN 305
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966937424 151 GTAQFEIYVKWAPPLERGRLTSMSTSGFLLGPFIVLLVTGVICESLGWPMVFYIFGACGCALCLLWFIL 219
Cdd:cd17474 306 LPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
137-219 |
8.19e-04 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 39.56 E-value: 8.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 137 IVCRAVQGAAQGIVGTAQFEIYVKWAPPLERGRLTSMSTSGFLLGPFIVLLVTGVICESLGWPMVFYIFGA-CGCALCLL 215
Cdd:TIGR00880 55 IIARFLQGFGAAFALVAGAALIADIYPPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAIlALAAFILL 134
|
....
gi 966937424 216 WFIL 219
Cdd:TIGR00880 135 AFLL 138
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
81-219 |
1.15e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 41.06 E-value: 1.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 81 GIILSSTFYGFVIIQVPVGYFSGIYSTKKMIGFALCLSSVLSLLIppAAGIGVAWVIVCRAVQGAAQGIVGTAQFEIYVK 160
Cdd:cd06173 247 GLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVL--GLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQL 324
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 966937424 161 WAPPLERGRLTSMSTSGFLLGPFIVLLVTGVICESLGWPMVFYIFGACGCALCLLWFIL 219
Cdd:cd06173 325 RVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
134-204 |
1.33e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 41.02 E-value: 1.33e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 966937424 134 AWVIVCRAVQGAAQGIVGTAQFEIYVKWAPPLERGRLTSMSTSGFLLGPFIVLLVTGVICESLGWPMVFYI 204
Cdd:cd17503 85 ASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYI 155
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
72-420 |
1.88e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 40.61 E-value: 1.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 72 VYNWSPDIQGIILSSTFYGFVIIQVPVGYFSGIYSTKKMIGFALCLSSVLSLLIppAAGIGVAWVIVCRAVQGAAQGIVG 151
Cdd:COG0738 37 AFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLF--ALAPSYPLLLLALFLLGLGLGLLD 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 152 TAQfEIYVKWAPPLERGRLTSMSTS----GFLLGPFIVLLVTGVIcESLGWPMVFYIFGACGCALCLLWFILFYDDPKDH 227
Cdd:COG0738 115 VAA-NPYVAALGPETAASRLNLLHAffslGALLGPLLGGLLILLG-LSLSWHLPYLILAVLLLLLALLFLRSKLPEIEEE 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 228 PCISISEKEyitsslvqqvsssrqslPIKAMLKSLPVWAISIGSFTFFWSHIIMTLYTPLFINSTLRVNIKENGFLSSLp 307
Cdd:COG0738 193 EEEAAGSAA-----------------SLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSL- 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 308 YLFAWICGNLVGqlsDFFLTRnilsvIAVRKLFTAAGFLlpAIFGVCLPHLSSSFYGIVIFLILVSATGSFCLGGVLING 387
Cdd:COG0738 255 FWGGMTIGRFLG---GFLLKR-----FGPVRLLRLSALL--AAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLA 324
|
330 340 350
....*....|....*....|....*....|...
gi 966937424 388 LDIAPRYFGFIKACSTLSGMLGGLIASTLTGLI 420
Cdd:COG0738 325 LDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFL 357
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
72-219 |
1.92e-03 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 40.24 E-value: 1.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 72 VYNWSPDIQGIILSSTFYGFVIIQVPVGYFSGIYSTKKMIGFALCLSSVLSLLIPPAAGIGVAWVIVCRAVQGAAQGIVG 151
Cdd:COG2271 210 VRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAF 289
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966937424 152 TAQFEIYVKWAPPLERGRLTSMSTSGFLLGPFIVLLVTGVICESLGWPMVFYIFGACGCALCLLWFIL 219
Cdd:COG2271 290 GLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLL 357
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
135-227 |
2.85e-03 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 40.05 E-value: 2.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 135 WVIVCRAVQGAAQGIVGTAQFEIYVKWAPPLERGRLTSMSTSGFLLGPFIVLLVTGVICESLGWPMVFYIFGACGCALCL 214
Cdd:TIGR00711 92 LMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIVVV 171
|
90
....*....|....
gi 966937424 215 L-WFILFYDDPKDH 227
Cdd:TIGR00711 172 VaFFILPRDKPAAS 185
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
128-375 |
2.91e-03 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 39.98 E-value: 2.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 128 AAGIGVAWVIVCRAVQGAAQGIVGTAQFEIYVKWAPPLERGRLTSMSTSGFLLGPFIV-LLVTGVICESLGWPMVFYIFG 206
Cdd:cd06180 82 ALTSGFAALLALRFLAGAASAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSgLLVPAGLGGGLSWRAGWLALA 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 207 ACGCALCLLWFILFYDDPKDHPcisisekeyitsslvqqvsssRQSLPIKAMLKSLPVWAISIGSFTFFWSHIIMTLYTP 286
Cdd:cd06180 162 LLSAVLLLLSFLLLRRGPSAPT---------------------EASAAESAPGLNRPLWRLALAYGLFGFGYIITATFLP 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 287 LFINSTlrvnikenGFLSSLPYLFaWICGNLVGQLSDfFLTRNILSVIAVRKLFTAAgFLLPAIfGVCLPHLSSSFYGIV 366
Cdd:cd06180 221 LIARET--------GAGSLLAGLL-WSLFGLAAVPSC-FLWGALSDRWGTRRALAAN-LLVQAV-GVLLPLLSPGPAGLV 288
|
....*....
gi 966937424 367 IFLILVSAT 375
Cdd:cd06180 289 LSAVLFGGT 297
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
132-451 |
2.99e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 39.85 E-value: 2.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 132 GVAWVIVCRAVQGAAQGIVGTAQFEIYVKWAPPLERGRLTSMSTSGFLLGPFIVLLVTGVICESLGWPMVFYIFGacgcA 211
Cdd:cd17321 83 SLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINV----P 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 212 LCLLWFILfyddpkdhpcisisekeyitsslvqqvsssrqslpikamlkSLPVWAISIGSFTFFWSHIIMTLYTPLFINS 291
Cdd:cd17321 159 IGLVALLL-----------------------------------------ARTFSGAVLAAFLLGAALGGLLFLLPLYLQG 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 292 TLRVNIKENGFLSSLPYLFAWICGNLVGQLSDFFLTRNILSVIAvrkLFTAAGFLLPAIFGVclphlSSSFYGIVIFLIL 371
Cdd:cd17321 198 VLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGL---LLTAVGLLLLALLGA-----DSSVWLLLPGLVL 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 372 VSATGSFCLGGVLINGLDIAPRYF-----GFIKACSTLSGMLG-GLIASTLTGLILRQDPESAWFKTFILMAAINVTGLI 445
Cdd:cd17321 270 LGLGLGLFATPLTNAALSSVPKEKagaasGILNTARQLGGALGvALLGALLTAGLSANLGDSGVAALLSAAAAAFAAGFH 349
|
....*.
gi 966937424 446 FYLIVA 451
Cdd:cd17321 350 LAFLVA 355
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
76-229 |
7.22e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 38.34 E-value: 7.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966937424 76 SPDIQGIILSSTFYGFVIIQVPVGYFSGIYSTKKMIGFALCLSSVLSLLIPPAAGIgvAWVIVCRAVQGAAQGIVGTAQF 155
Cdd:cd17489 29 SEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSV--ALLLVLRLIHGIGWGAFTTAAA 106
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966937424 156 EIYVKWAPPLERGRLTSM----STSGFLLGPFIVLLVTGVicesLGWPMVFYIFGACGCALCLLWFILFYDDPKDHPC 229
Cdd:cd17489 107 TLVADIIPPSRRGEGIGYyglaTTLAMALGPALGLFLYQH----LGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEE 180
|
|
| |
