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Conserved domains on  [gi|966914329|ref|XP_014991136|]
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MORN repeat-containing protein 1 isoform X5 [Macaca mulatta]

Protein Classification

MORN repeat-containing protein( domain architecture ID 11468649)

membrane-occupation-and-recognition-nexus (MORN) repeat-containing protein may be involved in protein-protein interactions

PubMed:  33296386|35568981

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
27-183 1.59e-36

Uncharacterized conserved protein [Function unknown];


:

Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 135.47  E-value: 1.59e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966914329  27 HGKLLFKDGSYYEGAFVDGEITGEGRRHWAwSGDTFSGQFVLGEPQGHGVMEYKAGGCYEGEVSHGMREGRGFLVDRDGQ 106
Cdd:COG4642  116 GGVLEGDDGGGYGGGTADGGRGGGGIYTFP-NGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYANGD 194

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966914329 107 VYQGSFHDNKRHGPGQMLFKNGDKYDGDWVRDQRQGHGVLRRTDGSTYEGQWHSDVFSGLGSMAHCSGVTYYGLWIN 183
Cdd:COG4642  195 VYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLTYADGDRYEGEFKNGKRHGQGTMTYADGSVYEGEWKN 271
 
Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
27-183 1.59e-36

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 135.47  E-value: 1.59e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966914329  27 HGKLLFKDGSYYEGAFVDGEITGEGRRHWAwSGDTFSGQFVLGEPQGHGVMEYKAGGCYEGEVSHGMREGRGFLVDRDGQ 106
Cdd:COG4642  116 GGVLEGDDGGGYGGGTADGGRGGGGIYTFP-NGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYANGD 194

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966914329 107 VYQGSFHDNKRHGPGQMLFKNGDKYDGDWVRDQRQGHGVLRRTDGSTYEGQWHSDVFSGLGSMAHCSGVTYYGLWIN 183
Cdd:COG4642  195 VYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLTYADGDRYEGEFKNGKRHGQGTMTYADGSVYEGEWKN 271
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 28-184 4.67e-22

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 99.52  E-value: 4.67e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966914329  28 GKLLFKDGSYYEGAFVDGEITGEGRRHWAwSGDTFSGQFVLGEPQGHGVMEYKAGGCYEGEVSHGMREGRGFLVDRDGQV 107
Cdd:PLN03185   1 GELVLSNGDFYSGSLLGNVPEGPGKYLWS-DGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGTYTGTDGTT 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966914329 108 YQGSFHDNKRHGPGQMLFKNGDKYDGDWVRDQRQGHGVLRRTDGSTYEGQWHSDVFSGLGSMAHCSGVTYYGLWING 184
Cdd:PLN03185  80 YKGRWRLNLKHGLGYQRYPNGDVFEGSWIQGLQEGPGKYTWANGNVYLGDMKGGKMSGKGTLTWVSGDSYEGQWLDG 156
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
129-150 2.33e-03

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 35.39  E-value: 2.33e-03
                           10        20
                   ....*....|....*....|..
gi 966914329   129 DKYDGDWVRDQRQGHGVLRRTD 150
Cdd:smart00698   1 DRYEGEWRNGKRHGRGVYTYAN 22
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 108-130 5.32e-03

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 34.31  E-value: 5.32e-03
                          10        20
                  ....*....|....*....|...
gi 966914329  108 YQGSFHDNKRHGPGQMLFKNGDK 130
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDGDR 23
 
Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
27-183 1.59e-36

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 135.47  E-value: 1.59e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966914329  27 HGKLLFKDGSYYEGAFVDGEITGEGRRHWAwSGDTFSGQFVLGEPQGHGVMEYKAGGCYEGEVSHGMREGRGFLVDRDGQ 106
Cdd:COG4642  116 GGVLEGDDGGGYGGGTADGGRGGGGIYTFP-NGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYANGD 194

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966914329 107 VYQGSFHDNKRHGPGQMLFKNGDKYDGDWVRDQRQGHGVLRRTDGSTYEGQWHSDVFSGLGSMAHCSGVTYYGLWIN 183
Cdd:COG4642  195 VYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLTYADGDRYEGEFKNGKRHGQGTMTYADGSVYEGEWKN 271
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
28-186 1.51e-29

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 116.59  E-value: 1.51e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966914329  28 GKLLFKDGSYYEGAFVDGEITGEGRRHWAwSGDTFSGQFVLGEPQGHGVMEYKAGGCYEGEVSHGMREGRGFLVDRDGQV 107
Cdd:COG4642   94 GEGGFGGGGGGGGGKKGGGGGGGGVLEGD-DGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPHGQGTLTYADGDR 172

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966914329 108 YQGSFHDNKRHGPGQMLFKNGDKYDGDWVRDQRQGHGVLRRTDGSTYEGQWHSDVFSGLGSMAHCSGVTYYGLWINGHP 186
Cdd:COG4642  173 YEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLTYADGDRYEGEFKNGKR 251
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
27-184 1.04e-25

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 105.81  E-value: 1.04e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966914329  27 HGKLLFKDGSYYEGAFVDGEITGEGRRHWAWS-----------GDTFSGQFVLGEPQGHGVMEYKAGGCYEGEVSHGMRE 95
Cdd:COG4642   58 GGTGVAGGGGGEGGVTAAGGGGGGGGGKGDGGdggggeggfggGGGGGGGKKGGGGGGGGVLEGDDGGGYGGGTADGGRG 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966914329  96 GRGFLVDRDGQVYQGSFHDNKRHGPGQMLFKNGDKYDGDWVRDQRQGHGVLRRTDGSTYEGQWHSDVFSGLGSMAHCSGV 175
Cdd:COG4642  138 GGGIYTFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYADGD 217


                 ....*....
gi 966914329 176 TYYGLWING 184
Cdd:COG4642  218 RYEGEFKNG 226
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 28-184 4.67e-22

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 99.52  E-value: 4.67e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966914329  28 GKLLFKDGSYYEGAFVDGEITGEGRRHWAwSGDTFSGQFVLGEPQGHGVMEYKAGGCYEGEVSHGMREGRGFLVDRDGQV 107
Cdd:PLN03185   1 GELVLSNGDFYSGSLLGNVPEGPGKYLWS-DGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGTYTGTDGTT 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966914329 108 YQGSFHDNKRHGPGQMLFKNGDKYDGDWVRDQRQGHGVLRRTDGSTYEGQWHSDVFSGLGSMAHCSGVTYYGLWING 184
Cdd:PLN03185  80 YKGRWRLNLKHGLGYQRYPNGDVFEGSWIQGLQEGPGKYTWANGNVYLGDMKGGKMSGKGTLTWVSGDSYEGQWLDG 156
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 28-184 7.12e-20

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 92.97  E-value: 7.12e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966914329  28 GKLLFKDGSYYEGAFVDGEITGEGRRHWAwSGDTFSGQFVLGEPQGHGVMEYKAGGCYEGEVSHGMREGRGFLVDRDGQV 107
Cdd:PLN03185  24 GKYLWSDGCMYEGEWRRGMRHGNGKISWP-SGATYEGEFSGGYMHGSGTYTGTDGTTYKGRWRLNLKHGLGYQRYPNGDV 102

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966914329 108 YQGSFHDNKRHGPGQMLFKNGDKYDGDWVRDQRQGHGVLRRTDGSTYEGQWHSDVFSGLGSMAHCSGVTYYGLWING 184
Cdd:PLN03185 103 FEGSWIQGLQEGPGKYTWANGNVYLGDMKGGKMSGKGTLTWVSGDSYEGQWLDGMMHGFGVYTWSDGGCYVGTWTRG 179
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 28-168 1.11e-16

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 82.96  E-value: 1.11e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966914329  28 GKLLFKDGSYYEGAFVDGEITGEGRrHWAWSGDTFSGQFVLGEPQGHGVMEYKAGGCYEGEVSHGMREGRGFLVDRDGQV 107
Cdd:PLN03185  47 GKISWPSGATYEGEFSGGYMHGSGT-YTGTDGTTYKGRWRLNLKHGLGYQRYPNGDVFEGSWIQGLQEGPGKYTWANGNV 125

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 966914329 108 YQGSFHDNKRHGPGQMLFKNGDKYDGDWVRDQRQGHGVLRRTDGSTYEGQWHSDVFSGLGS 168
Cdd:PLN03185 126 YLGDMKGGKMSGKGTLTWVSGDSYEGQWLDGMMHGFGVYTWSDGGCYVGTWTRGLKDGKGV 186
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 82-186 1.66e-12

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 69.86  E-value: 1.66e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966914329  82 GGCYEGEVSHGMREGRGFLVDRDGQVYQGSFHDNKRHGPGQMLFKNGDKYDGDWVRDQRQGHGVLRRTDGSTYEGQWHSD 161
Cdd:PLN03185   8 GDFYSGSLLGNVPEGPGKYLWSDGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGTYTGTDGTTYKGRWRLN 87

                         90       100
                 ....*....|....*....|....*
gi 966914329 162 VFSGLGSMAHCSGVTYYGLWINGHP 186
Cdd:PLN03185  88 LKHGLGYQRYPNGDVFEGSWIQGLQ 112
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
28-186 1.37e-09

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 58.81  E-value: 1.37e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966914329  28 GKLLFKDGSYYEGAFVDGEITGEGRrhWAWSGDTFSGQFVLGEPQGHGVMEYKAGGCYEGEVSHGMRE------------ 95
Cdd:COG4642   13 GDATALGGGGEGGLAAAGGEGGGGL--GTLPGGGGYGGGADGGGGGGGGTGVAGGGGGEGGVTAAGGGggggggkgdggd 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966914329  96 -GRGFLVDRDGQVYQGSFHDNKRHGPGQMLFKNGDKYDGDWVRDQRQGHGVLRRTDGSTYEGQWHSDVFSGLGSMAHCSG 174
Cdd:COG4642   91 gGGGEGGFGGGGGGGGGKKGGGGGGGGVLEGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPHGQGTLTYADG 170

                        170
                 ....*....|..
gi 966914329 175 VTYYGLWINGHP 186
Cdd:COG4642  171 DRYEGEFKNGKR 182
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 121-185 4.10e-05

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 45.98  E-value: 4.10e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966914329 121 GQMLFKNGDKYDGDWVRDQRQGHGVLRRTDGSTYEGQWHSDVFSGLGSMAHCSGVTYYGLWINGH 185
Cdd:PLN03185   1 GELVLSNGDFYSGSLLGNVPEGPGKYLWSDGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGY 65
YwqK COG2849
Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];
32-128 8.85e-04

Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];


Pssm-ID: 442097 [Multi-domain]  Cd Length: 163  Bit Score: 40.05  E-value: 8.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966914329  32 FKDGSYYEGAFVDGEITGEgRRHWAWSGD-TFSGQFVLGEPQGHGVMEYKAGG-CYEGEVSHGMREGRGFLVDRDGQV-Y 108
Cdd:COG2849   51 IKKKLGKGLGKYKKGKLGE-WKTYYPNGQlKSEGTYKNGKLEGEWKEYYENGKlKSEGNYKNGKLHGEWKEYYENGKLkE 129

                         90       100
                 ....*....|....*....|
gi 966914329 109 QGSFHDNKRHGPGQMLFKNG 128
Cdd:COG2849  130 EGNYKNGKKDGVWKYYDENG 149
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
129-150 2.33e-03

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 35.39  E-value: 2.33e-03
                           10        20
                   ....*....|....*....|..
gi 966914329   129 DKYDGDWVRDQRQGHGVLRRTD 150
Cdd:smart00698   1 DRYEGEWRNGKRHGRGVYTYAN 22
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 108-130 5.32e-03

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 34.31  E-value: 5.32e-03
                          10        20
                  ....*....|....*....|...
gi 966914329  108 YQGSFHDNKRHGPGQMLFKNGDK 130
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDGDR 23
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
107-127 5.42e-03

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 34.24  E-value: 5.42e-03
                           10        20
                   ....*....|....*....|.
gi 966914329   107 VYQGSFHDNKRHGPGQMLFKN 127
Cdd:smart00698   2 RYEGEWRNGKRHGRGVYTYAN 22
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 131-153 6.86e-03

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 33.92  E-value: 6.86e-03
                          10        20
                  ....*....|....*....|...
gi 966914329  131 YDGDWVRDQRQGHGVLRRTDGST 153
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDGDR 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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