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Conserved domains on  [gi|966916555|ref|XP_014990985|]
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granulocyte colony-stimulating factor receptor isoform X1 [Macaca mulatta]

Protein Classification

Lep_receptor_Ig and FN3 domain-containing protein( domain architecture ID 11162510)

protein containing domains Lep_receptor_Ig, and FN3

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lep_receptor_Ig pfam06328
Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two ...
 24-110 1.35e-36

Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.


:

Pssm-ID: 461878  Cd Length: 87  Bit Score: 132.37  E-value: 1.35e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966916555   24 EECGHISVSAPIVHLGDPITASCIIKQN-CSHLDLEPQ-ILWRLGAELQPGGRQQRLSDGSqqSTITLPHLNHTRAFLSC 101
Cdd:pfam06328   1 EPCGHISPSPPVVRLGSNVTASCILKENcCSHLGVEAQiIVWKLGLELIPGSQYTVLNDTV--SSVTLPNLNSTRALLTC 78


                  ....*....
gi 966916555  102 CLNWGNSLQ 110
Cdd:pfam06328  79 CLLWGGQLQ 87
fn3 pfam00041
Fibronectin type III domain;
530-607 6.03e-08

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 50.88  E-value: 6.03e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966916555  530 APE-LHLKHIGKTWAQLEWvpEPPELGKSPLTHYTIFW--TNAQNQSFSTILNASSRGFVLHGLEPASLYHIHLMAASQA 606
Cdd:pfam00041   2 APSnLTVTDVTSTSLTVSW--TPPPDGNGPITGYEVEYrpKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                  .
gi 966916555  607 G 607
Cdd:pfam00041  80 G 80
fn3 pfam00041
Fibronectin type III domain;
430-514 2.79e-07

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.95  E-value: 2.79e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966916555  430 PALTRLHAMARDPHSLWVGWEPPSPWPR---GYVIEWglsppSTSNSNKTWRMEQNGSATGFLLQENIRPFQLYEITVTP 506
Cdd:pfam00041   1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGpitGYEVEY-----RPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQA 75


                  ....*...
gi 966916555  507 LYQDAMGP 514
Cdd:pfam00041  76 VNGGGEGP 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 249-329 2.80e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 43.64  E-value: 2.80e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966916555 249 LQLCWEPWQPALHINQKCELRHKPqSGEASWALVGPLPLEALRYELCGLLPATAYTLQIRCIRwplPGHWSNWSPSLELR 328
Cdd:cd00063   17 VTLSWTPPEDDGGPITGYVVEYRE-KGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVN---GGGESPPSESVTVT 92


                 .
gi 966916555 329 T 329
Cdd:cd00063   93 T 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 345-423 7.73e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.10  E-value: 7.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966916555 345 RQLDPRTVQLFWKPVPleEDSGQIQGYVVSWRPSGQAGAI-LPLCNTTELSCTFP--LPSEAQEVALVAYNSAGTSCPTP 421
Cdd:cd00063   10 TDVTSTSVTLSWTPPE--DDGGPITGYVVEYREKGSGDWKeVEVTPGSETSYTLTglKPGTEYEFRVRAVNGGGESPPSE 87


                 ..
gi 966916555 422 VV 423
Cdd:cd00063   88 SV 89
FN3 super family cl21522
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 122-220 7.78e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


The actual alignment was detected with superfamily member pfam09067:

Pssm-ID: 473895  Cd Length: 104  Bit Score: 42.41  E-value: 7.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966916555  122 PPAVPRNLSCLMNlTTSSLICQWEPGPETHLPTSFTLkSFksrgncQTQGDSIMDC------VPEDGQSH-CSIPRRHLL 194
Cdd:pfam09067   7 LPEKPEDIKCFSR-EKEDFTCFWEEEEDGGLPTTYSF-SY------AYENETVKECplystsGANSTRLFiCFFPKNDVS 78

                          90       100
                  ....*....|....*....|....*.
gi 966916555  195 LYQNMGIWVQAENALGTSMSPQLCLE 220
Cdd:pfam09067  79 LFVPLHITVVATNTNGTRYSRELSVE 104
 
Name Accession Description Interval E-value
Lep_receptor_Ig pfam06328
Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two ...
 24-110 1.35e-36

Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.


Pssm-ID: 461878  Cd Length: 87  Bit Score: 132.37  E-value: 1.35e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966916555   24 EECGHISVSAPIVHLGDPITASCIIKQN-CSHLDLEPQ-ILWRLGAELQPGGRQQRLSDGSqqSTITLPHLNHTRAFLSC 101
Cdd:pfam06328   1 EPCGHISPSPPVVRLGSNVTASCILKENcCSHLGVEAQiIVWKLGLELIPGSQYTVLNDTV--SSVTLPNLNSTRALLTC 78


                  ....*....
gi 966916555  102 CLNWGNSLQ 110
Cdd:pfam06328  79 CLLWGGQLQ 87
fn3 pfam00041
Fibronectin type III domain;
530-607 6.03e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 50.88  E-value: 6.03e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966916555  530 APE-LHLKHIGKTWAQLEWvpEPPELGKSPLTHYTIFW--TNAQNQSFSTILNASSRGFVLHGLEPASLYHIHLMAASQA 606
Cdd:pfam00041   2 APSnLTVTDVTSTSLTVSW--TPPPDGNGPITGYEVEYrpKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                  .
gi 966916555  607 G 607
Cdd:pfam00041  80 G 80
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 526-607 8.18e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.57  E-value: 8.18e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966916555 526 APRHapeLHLKHIGKTWAQLEWvpEPPELGKSPLTHYTIFWTNAQNQSFSTILN--ASSRGFVLHGLEPASLYHIHLMAA 603
Cdd:cd00063    3 PPTN---LRVTDVTSTSVTLSW--TPPEDDGGPITGYVVEYREKGSGDWKEVEVtpGSETSYTLTGLKPGTEYEFRVRAV 77


                 ....
gi 966916555 604 SQAG 607
Cdd:cd00063   78 NGGG 81
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 527-607 1.46e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.54  E-value: 1.46e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966916555   527 PRHAPELHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQSFSTILNASSRGFVLHGLEPASLYHIHLMAASQA 606
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                   .
gi 966916555   607 G 607
Cdd:smart00060  81 G 81
fn3 pfam00041
Fibronectin type III domain;
430-514 2.79e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.95  E-value: 2.79e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966916555  430 PALTRLHAMARDPHSLWVGWEPPSPWPR---GYVIEWglsppSTSNSNKTWRMEQNGSATGFLLQENIRPFQLYEITVTP 506
Cdd:pfam00041   1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGpitGYEVEY-----RPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQA 75


                  ....*...
gi 966916555  507 LYQDAMGP 514
Cdd:pfam00041  76 VNGGGEGP 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 249-329 2.80e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 43.64  E-value: 2.80e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966916555 249 LQLCWEPWQPALHINQKCELRHKPqSGEASWALVGPLPLEALRYELCGLLPATAYTLQIRCIRwplPGHWSNWSPSLELR 328
Cdd:cd00063   17 VTLSWTPPEDDGGPITGYVVEYRE-KGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVN---GGGESPPSESVTVT 92


                 .
gi 966916555 329 T 329
Cdd:cd00063   93 T 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 345-423 7.73e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.10  E-value: 7.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966916555 345 RQLDPRTVQLFWKPVPleEDSGQIQGYVVSWRPSGQAGAI-LPLCNTTELSCTFP--LPSEAQEVALVAYNSAGTSCPTP 421
Cdd:cd00063   10 TDVTSTSVTLSWTPPE--DDGGPITGYVVEYREKGSGDWKeVEVTPGSETSYTLTglKPGTEYEFRVRAVNGGGESPPSE 87


                 ..
gi 966916555 422 VV 423
Cdd:cd00063   88 SV 89
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
 122-220 7.78e-05

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


Pssm-ID: 401127  Cd Length: 104  Bit Score: 42.41  E-value: 7.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966916555  122 PPAVPRNLSCLMNlTTSSLICQWEPGPETHLPTSFTLkSFksrgncQTQGDSIMDC------VPEDGQSH-CSIPRRHLL 194
Cdd:pfam09067   7 LPEKPEDIKCFSR-EKEDFTCFWEEEEDGGLPTTYSF-SY------AYENETVKECplystsGANSTRLFiCFFPKNDVS 78

                          90       100
                  ....*....|....*....|....*.
gi 966916555  195 LYQNMGIWVQAENALGTSMSPQLCLE 220
Cdd:pfam09067  79 LFVPLHITVVATNTNGTRYSRELSVE 104
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 430-514 9.51e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 39.02  E-value: 9.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966916555 430 PALTRLHAMARDPHSLWVGWEPPSPWPR---GYVIEWglsppsTSNSNKTWRM--EQNGSATGFLLqENIRPFQLYEITV 504
Cdd:cd00063    2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGpitGYVVEY------REKGSGDWKEveVTPGSETSYTL-TGLKPGTEYEFRV 74

                         90
                 ....*....|
gi 966916555 505 TPLYQDAMGP 514
Cdd:cd00063   75 RAVNGGGESP 84
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 433-505 1.97e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 37.98  E-value: 1.97e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966916555   433 TRLHAMARDPHSLWVGWEPPSPW-PRGYVIEWGLSPPSTSNSNKtwRMEQNGSATGFLLqENIRPFQLYEITVT 505
Cdd:smart00060   5 SNLRVTDVTSTSVTLSWEPPPDDgITGYIVGYRVEYREEGSEWK--EVNVTPSSTSYTL-TGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 345-417 7.13e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 36.44  E-value: 7.13e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966916555   345 RQLDPRTVQLFWKPVPLEEDSGQIQGYVVSWRPSGQAGAILPlCNTTELSCTFP--LPSEAQEVALVAYNSAGTS 417
Cdd:smart00060  10 TDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVN-VTPSSTSYTLTglKPGTEYEFRVRAVNGAGEG 83
 
Name Accession Description Interval E-value
Lep_receptor_Ig pfam06328
Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two ...
 24-110 1.35e-36

Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.


Pssm-ID: 461878  Cd Length: 87  Bit Score: 132.37  E-value: 1.35e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966916555   24 EECGHISVSAPIVHLGDPITASCIIKQN-CSHLDLEPQ-ILWRLGAELQPGGRQQRLSDGSqqSTITLPHLNHTRAFLSC 101
Cdd:pfam06328   1 EPCGHISPSPPVVRLGSNVTASCILKENcCSHLGVEAQiIVWKLGLELIPGSQYTVLNDTV--SSVTLPNLNSTRALLTC 78


                  ....*....
gi 966916555  102 CLNWGNSLQ 110
Cdd:pfam06328  79 CLLWGGQLQ 87
fn3 pfam00041
Fibronectin type III domain;
530-607 6.03e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 50.88  E-value: 6.03e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966916555  530 APE-LHLKHIGKTWAQLEWvpEPPELGKSPLTHYTIFW--TNAQNQSFSTILNASSRGFVLHGLEPASLYHIHLMAASQA 606
Cdd:pfam00041   2 APSnLTVTDVTSTSLTVSW--TPPPDGNGPITGYEVEYrpKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                  .
gi 966916555  607 G 607
Cdd:pfam00041  80 G 80
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 526-607 8.18e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.57  E-value: 8.18e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966916555 526 APRHapeLHLKHIGKTWAQLEWvpEPPELGKSPLTHYTIFWTNAQNQSFSTILN--ASSRGFVLHGLEPASLYHIHLMAA 603
Cdd:cd00063    3 PPTN---LRVTDVTSTSVTLSW--TPPEDDGGPITGYVVEYREKGSGDWKEVEVtpGSETSYTLTGLKPGTEYEFRVRAV 77


                 ....
gi 966916555 604 SQAG 607
Cdd:cd00063   78 NGGG 81
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 527-607 1.46e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.54  E-value: 1.46e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966916555   527 PRHAPELHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQSFSTILNASSRGFVLHGLEPASLYHIHLMAASQA 606
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                   .
gi 966916555   607 G 607
Cdd:smart00060  81 G 81
fn3 pfam00041
Fibronectin type III domain;
430-514 2.79e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.95  E-value: 2.79e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966916555  430 PALTRLHAMARDPHSLWVGWEPPSPWPR---GYVIEWglsppSTSNSNKTWRMEQNGSATGFLLQENIRPFQLYEITVTP 506
Cdd:pfam00041   1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGpitGYEVEY-----RPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQA 75


                  ....*...
gi 966916555  507 LYQDAMGP 514
Cdd:pfam00041  76 VNGGGEGP 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 249-329 2.80e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 43.64  E-value: 2.80e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966916555 249 LQLCWEPWQPALHINQKCELRHKPqSGEASWALVGPLPLEALRYELCGLLPATAYTLQIRCIRwplPGHWSNWSPSLELR 328
Cdd:cd00063   17 VTLSWTPPEDDGGPITGYVVEYRE-KGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVN---GGGESPPSESVTVT 92


                 .
gi 966916555 329 T 329
Cdd:cd00063   93 T 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 345-423 7.73e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.10  E-value: 7.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966916555 345 RQLDPRTVQLFWKPVPleEDSGQIQGYVVSWRPSGQAGAI-LPLCNTTELSCTFP--LPSEAQEVALVAYNSAGTSCPTP 421
Cdd:cd00063   10 TDVTSTSVTLSWTPPE--DDGGPITGYVVEYREKGSGDWKeVEVTPGSETSYTLTglKPGTEYEFRVRAVNGGGESPPSE 87


                 ..
gi 966916555 422 VV 423
Cdd:cd00063   88 SV 89
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
 122-220 7.78e-05

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


Pssm-ID: 401127  Cd Length: 104  Bit Score: 42.41  E-value: 7.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966916555  122 PPAVPRNLSCLMNlTTSSLICQWEPGPETHLPTSFTLkSFksrgncQTQGDSIMDC------VPEDGQSH-CSIPRRHLL 194
Cdd:pfam09067   7 LPEKPEDIKCFSR-EKEDFTCFWEEEEDGGLPTTYSF-SY------AYENETVKECplystsGANSTRLFiCFFPKNDVS 78

                          90       100
                  ....*....|....*....|....*.
gi 966916555  195 LYQNMGIWVQAENALGTSMSPQLCLE 220
Cdd:pfam09067  79 LFVPLHITVVATNTNGTRYSRELSVE 104
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 430-514 9.51e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 39.02  E-value: 9.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966916555 430 PALTRLHAMARDPHSLWVGWEPPSPWPR---GYVIEWglsppsTSNSNKTWRM--EQNGSATGFLLqENIRPFQLYEITV 504
Cdd:cd00063    2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGpitGYVVEY------REKGSGDWKEveVTPGSETSYTL-TGLKPGTEYEFRV 74

                         90
                 ....*....|
gi 966916555 505 TPLYQDAMGP 514
Cdd:cd00063   75 RAVNGGGESP 84
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 433-505 1.97e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 37.98  E-value: 1.97e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966916555   433 TRLHAMARDPHSLWVGWEPPSPW-PRGYVIEWGLSPPSTSNSNKtwRMEQNGSATGFLLqENIRPFQLYEITVT 505
Cdd:smart00060   5 SNLRVTDVTSTSVTLSWEPPPDDgITGYIVGYRVEYREEGSEWK--EVNVTPSSTSYTL-TGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 345-417 7.13e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 36.44  E-value: 7.13e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966916555   345 RQLDPRTVQLFWKPVPLEEDSGQIQGYVVSWRPSGQAGAILPlCNTTELSCTFP--LPSEAQEVALVAYNSAGTS 417
Cdd:smart00060  10 TDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVN-VTPSSTSYTLTglKPGTEYEFRVRAVNGAGEG 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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