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Conserved domains on  [gi|1622927610|ref|XP_014990746|]
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replication initiator 1 isoform X3 [Macaca mulatta]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
233-565 3.22e-11

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.49  E-value: 3.22e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622927610 233 DRPFQCACCGKRFRHKPNLIAHRRVHTGERPHQC--PECGKRFTNKPYLTSHRRIHTGEKPY-PCKECGRRFRHKPNLLS 309
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDlNSKSLPLSNSKASSSSL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622927610 310 HSKIHKRSEGSAQAIPGPGSPQP-------------------------PAGPQESAAEPtPAAPLKPAQEPPPGAPPEPP 364
Cdd:COG5048   111 SSSSSNSNDNNLLSSHSLPPSSRdpqlpdllsisnlrnnplpgnnsssVNTPQSNSLHP-PLPANSLSKDPSSNLSLLIS 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622927610 365 QDRAEAPPSLYCCDDCGRS-------------------------FRLERFLRAHQRQHTGER--PFTCAECGKNFGKKTH 417
Cdd:COG5048   190 SNVSTSIPSSSENSPLSSSysipssssdqnlensssslplttnsQLSPKSLLSQSPSSLSSSdsSSSASESPRSSLPTAS 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622927610 418 LVAHSRVHSGER-------PFVCEECGRRFSQGSHLAAHRR--DH--APDRPFVCP--DCGKAFRHKPYLAAHRRIHTGE 484
Cdd:COG5048   270 SQSSSPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLRsvNHsgESLKPFSCPysLCGKLFSRNDALKRHILLHTSI 349

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622927610 485 KPYVCP--DCGKAFSQKSN-----LVSHRRIHTGERPYAC--PDCDRSFSQKSNLITHRKSHIRDGAFCC--AICGQTFD 553
Cdd:COG5048   350 SPAKEKllNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFN 429

                         410
                  ....*....|..
gi 1622927610 554 DEERLLAHQKKH 565
Cdd:COG5048   430 RHYNLIPHKKIH 441
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
233-565 3.22e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.49  E-value: 3.22e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622927610 233 DRPFQCACCGKRFRHKPNLIAHRRVHTGERPHQC--PECGKRFTNKPYLTSHRRIHTGEKPY-PCKECGRRFRHKPNLLS 309
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDlNSKSLPLSNSKASSSSL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622927610 310 HSKIHKRSEGSAQAIPGPGSPQP-------------------------PAGPQESAAEPtPAAPLKPAQEPPPGAPPEPP 364
Cdd:COG5048   111 SSSSSNSNDNNLLSSHSLPPSSRdpqlpdllsisnlrnnplpgnnsssVNTPQSNSLHP-PLPANSLSKDPSSNLSLLIS 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622927610 365 QDRAEAPPSLYCCDDCGRS-------------------------FRLERFLRAHQRQHTGER--PFTCAECGKNFGKKTH 417
Cdd:COG5048   190 SNVSTSIPSSSENSPLSSSysipssssdqnlensssslplttnsQLSPKSLLSQSPSSLSSSdsSSSASESPRSSLPTAS 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622927610 418 LVAHSRVHSGER-------PFVCEECGRRFSQGSHLAAHRR--DH--APDRPFVCP--DCGKAFRHKPYLAAHRRIHTGE 484
Cdd:COG5048   270 SQSSSPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLRsvNHsgESLKPFSCPysLCGKLFSRNDALKRHILLHTSI 349

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622927610 485 KPYVCP--DCGKAFSQKSN-----LVSHRRIHTGERPYAC--PDCDRSFSQKSNLITHRKSHIRDGAFCC--AICGQTFD 553
Cdd:COG5048   350 SPAKEKllNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFN 429

                         410
                  ....*....|..
gi 1622927610 554 DEERLLAHQKKH 565
Cdd:COG5048   430 RHYNLIPHKKIH 441
zf-H2C2_2 pfam13465
Zinc-finger double domain;
501-526 2.97e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.97e-04
                          10        20
                  ....*....|....*....|....*.
gi 1622927610 501 NLVSHRRIHTGERPYACPDCDRSFSQ 526
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 514-567 9.71e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 36.39  E-value: 9.71e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622927610 514 PYACPDCDRSFSQKSNLithrKSHIR--DGAFCCAICGQTFDDEERLLAHQ-KKHDV 567
Cdd:PHA00733   73 PYVCPLCLMPFSSSVSL----KQHIRytEHSKVCPVCGKEFRNTDSTLDHVcKKHNI 125
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
233-565 3.22e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.49  E-value: 3.22e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622927610 233 DRPFQCACCGKRFRHKPNLIAHRRVHTGERPHQC--PECGKRFTNKPYLTSHRRIHTGEKPY-PCKECGRRFRHKPNLLS 309
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDlNSKSLPLSNSKASSSSL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622927610 310 HSKIHKRSEGSAQAIPGPGSPQP-------------------------PAGPQESAAEPtPAAPLKPAQEPPPGAPPEPP 364
Cdd:COG5048   111 SSSSSNSNDNNLLSSHSLPPSSRdpqlpdllsisnlrnnplpgnnsssVNTPQSNSLHP-PLPANSLSKDPSSNLSLLIS 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622927610 365 QDRAEAPPSLYCCDDCGRS-------------------------FRLERFLRAHQRQHTGER--PFTCAECGKNFGKKTH 417
Cdd:COG5048   190 SNVSTSIPSSSENSPLSSSysipssssdqnlensssslplttnsQLSPKSLLSQSPSSLSSSdsSSSASESPRSSLPTAS 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622927610 418 LVAHSRVHSGER-------PFVCEECGRRFSQGSHLAAHRR--DH--APDRPFVCP--DCGKAFRHKPYLAAHRRIHTGE 484
Cdd:COG5048   270 SQSSSPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLRsvNHsgESLKPFSCPysLCGKLFSRNDALKRHILLHTSI 349

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622927610 485 KPYVCP--DCGKAFSQKSN-----LVSHRRIHTGERPYAC--PDCDRSFSQKSNLITHRKSHIRDGAFCC--AICGQTFD 553
Cdd:COG5048   350 SPAKEKllNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFN 429

                         410
                  ....*....|..
gi 1622927610 554 DEERLLAHQKKH 565
Cdd:COG5048   430 RHYNLIPHKKIH 441
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
254-540 2.09e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.09  E-value: 2.09e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622927610 254 HRRVHTGERPHQCPECGKRFTNKPYLTSHRRIHTGEKPYPCKECGRRFRHKPNLLSHSKIHKRSEgSAQAIPGPGSPQPP 333
Cdd:COG5048   189 SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDS-SSSASESPRSSLPT 267

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622927610 334 AGPQESAAEPTPAAPLKpaqepppgappeppqdraeAPPSLYCCDDCGRSFRLERFLRAHQRQ--HTGE--RPFTCAE-- 407
Cdd:COG5048   268 ASSQSSSPNESDSSSEK-------------------GFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYsl 328

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622927610 408 CGKNFGKKTHLVAHSRVHSGERPFVC--EECGRRFSQGSH-----LAAHRRDHAPDRPFVC--PDCGKAFRHKPYLAAHR 478
Cdd:COG5048   329 CGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHI 408

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622927610 479 RIHTGEKPYVC--PDCGKAFSQKSNLVSHRRIHTGERPYACPDCDRSFSQKsnlitHRKSHIRD 540
Cdd:COG5048   409 ITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDL-----DLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
235-424 6.88e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.01  E-value: 6.88e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622927610 235 PFQCACCGKRFRHKPNLIAHRR--VHTGE--RPHQCPE--CGKRFTNKPYLTSHRRIHTGEKPYPCKECGRRFRHKPNLl 308
Cdd:COG5048   289 PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLL- 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622927610 309 shskiHKRSEGSAQAIPGP--GSPQPPAGPQESAAEPTPAAPLKpaqepppgappePPQDRAEAPPSLYCCDDCGRSFRL 386
Cdd:COG5048   368 -----NNEPPQSLQQYKDLknDKKSETLSNSCIRNFKRDSNLSL------------HIITHLSFRPYNCKNPPCSKSFNR 430

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1622927610 387 ERFLRAHQRQHTGERPFTCAECGKNFGKKtHLVAHSRV 424
Cdd:COG5048   431 HYNLIPHKKIHTNHAPLLCSILKSFRRDL-DLSNHGKD 467
zf-H2C2_2 pfam13465
Zinc-finger double domain;
501-526 2.97e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.97e-04
                          10        20
                  ....*....|....*....|....*.
gi 1622927610 501 NLVSHRRIHTGERPYACPDCDRSFSQ 526
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
473-498 3.98e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.98e-04
                          10        20
                  ....*....|....*....|....*.
gi 1622927610 473 YLAAHRRIHTGEKPYVCPDCGKAFSQ 498
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
278-303 5.35e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.35e-04
                          10        20
                  ....*....|....*....|....*.
gi 1622927610 278 YLTSHRRIHTGEKPYPCKECGRRFRH 303
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
250-275 6.63e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.63e-04
                          10        20
                  ....*....|....*....|....*.
gi 1622927610 250 NLIAHRRVHTGERPHQCPECGKRFTN 275
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 487-509 9.99e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.51  E-value: 9.99e-04
                          10        20
                  ....*....|....*....|...
gi 1622927610 487 YVCPDCGKAFSQKSNLVSHRRIH 509
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 515-537 3.31e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 3.31e-03
                          10        20
                  ....*....|....*....|...
gi 1622927610 515 YACPDCDRSFSQKSNLITHRKSH 537
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 264-286 7.18e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 7.18e-03
                          10        20
                  ....*....|....*....|...
gi 1622927610 264 HQCPECGKRFTNKPYLTSHRRIH 286
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
PHA00733 PHA00733
hypothetical protein
 514-567 9.71e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 36.39  E-value: 9.71e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622927610 514 PYACPDCDRSFSQKSNLithrKSHIR--DGAFCCAICGQTFDDEERLLAHQ-KKHDV 567
Cdd:PHA00733   73 PYVCPLCLMPFSSSVSL----KQHIRytEHSKVCPVCGKEFRNTDSTLDHVcKKHNI 125
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 459-481 9.83e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 9.83e-03
                          10        20
                  ....*....|....*....|...
gi 1622927610 459 FVCPDCGKAFRHKPYLAAHRRIH 481
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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