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Conserved domains on  [gi|966935379|ref|XP_014990273|]
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tetraspanin-12 [Macaca mulatta]

Protein Classification

tetraspanin family protein( domain architecture ID 13626507)

tetraspanin family protein is a transmembrane (TM) glycoprotein with four TM segments that facilitates the interaction of membrane and intracellular signaling molecules (such as integrins, pro-growth factors and their receptors, protein kinase-C) in the formation of membrane signaling microdomains (also referred to as the tetraspanin web)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TM4SF12_like_LEL cd03157
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF12_like family. ...
 116-218 4.82e-68

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF12_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This sub-family contains proteins similar to human transmembrane 4 superfamily member 12 (TM4SF12).


:

Pssm-ID: 239410  Cd Length: 103  Bit Score: 207.09  E-value: 4.82e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966935379 116 EQELMVPVQWSDMVTLKARMTNYGLPRYRWLTHAWNFFQREFKCCGVVYFTDWLEMTEMDWPPDSCCVREFPGCSKQAHQ 195
Cdd:cd03157    1 WTYDEVPVQRSDMISLKSRMSNFGLQRYQWLTHAWNSFQTEFKCCGVIYFTDWLEMTEMEWPPDSCCSNQYPGCARQAHY 80

                         90       100
                 ....*....|....*....|...
gi 966935379 196 EDLSDLYQEGCGKKMYSFLRGTK 218
Cdd:cd03157   81 NDLSDLYQEGCGPKIYSFIRGTK 103
Tetraspanin pfam00335
Tetraspanin family;
10-246 5.68e-27

Tetraspanin family;


:

Pssm-ID: 459767  Cd Length: 183  Bit Score: 103.94  E-value: 5.68e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966935379   10 LRCLLYALNLLFWLMSISVLAVSAWMRDYLNNVLTLTAEtrveeaviltYFPVVHPVMIAVCCFLIIVGMLGYCGTVKRN 89
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWLLSAFSLLLLGLSE----------ASAYIPILLIVLGAVIFLVGFLGCCGALKEN 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966935379   90 LLLLAWYFGSLLVIFCVELACGVW--TYEQELMVPVQWSDMVTLKARMTNyGLPRYRWLTHAWNFFQREFKCCGvvyftd 167
Cdd:pfam00335  71 RCLLLTYFVLLLLLFLAELAAGILafVYRDKLSGLLSNWLKKSLEDGYRD-WLDLYSCLNSALDSLQSEFGCCG------ 143

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966935379  168 wlemtemdwppdsccvrefpgcskqahqedlsdlyqeGCGKKMYSFLRgtKQLQVLRFLGISIGVTQILAMILTITLLW 246
Cdd:pfam00335 144 -------------------------------------GCKEKLLEWLR--KNLKIIGAGVIALGVIQLLGIILACCLCC 183
 
Name Accession Description Interval E-value
TM4SF12_like_LEL cd03157
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF12_like family. ...
 116-218 4.82e-68

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF12_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This sub-family contains proteins similar to human transmembrane 4 superfamily member 12 (TM4SF12).


Pssm-ID: 239410  Cd Length: 103  Bit Score: 207.09  E-value: 4.82e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966935379 116 EQELMVPVQWSDMVTLKARMTNYGLPRYRWLTHAWNFFQREFKCCGVVYFTDWLEMTEMDWPPDSCCVREFPGCSKQAHQ 195
Cdd:cd03157    1 WTYDEVPVQRSDMISLKSRMSNFGLQRYQWLTHAWNSFQTEFKCCGVIYFTDWLEMTEMEWPPDSCCSNQYPGCARQAHY 80

                         90       100
                 ....*....|....*....|...
gi 966935379 196 EDLSDLYQEGCGKKMYSFLRGTK 218
Cdd:cd03157   81 NDLSDLYQEGCGPKIYSFIRGTK 103
Tetraspanin pfam00335
Tetraspanin family;
10-246 5.68e-27

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 103.94  E-value: 5.68e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966935379   10 LRCLLYALNLLFWLMSISVLAVSAWMRDYLNNVLTLTAEtrveeaviltYFPVVHPVMIAVCCFLIIVGMLGYCGTVKRN 89
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWLLSAFSLLLLGLSE----------ASAYIPILLIVLGAVIFLVGFLGCCGALKEN 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966935379   90 LLLLAWYFGSLLVIFCVELACGVW--TYEQELMVPVQWSDMVTLKARMTNyGLPRYRWLTHAWNFFQREFKCCGvvyftd 167
Cdd:pfam00335  71 RCLLLTYFVLLLLLFLAELAAGILafVYRDKLSGLLSNWLKKSLEDGYRD-WLDLYSCLNSALDSLQSEFGCCG------ 143

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966935379  168 wlemtemdwppdsccvrefpgcskqahqedlsdlyqeGCGKKMYSFLRgtKQLQVLRFLGISIGVTQILAMILTITLLW 246
Cdd:pfam00335 144 -------------------------------------GCKEKLLEWLR--KNLKIIGAGVIALGVIQLLGIILACCLCC 183
 
Name Accession Description Interval E-value
TM4SF12_like_LEL cd03157
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF12_like family. ...
 116-218 4.82e-68

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF12_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This sub-family contains proteins similar to human transmembrane 4 superfamily member 12 (TM4SF12).


Pssm-ID: 239410  Cd Length: 103  Bit Score: 207.09  E-value: 4.82e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966935379 116 EQELMVPVQWSDMVTLKARMTNYGLPRYRWLTHAWNFFQREFKCCGVVYFTDWLEMTEMDWPPDSCCVREFPGCSKQAHQ 195
Cdd:cd03157    1 WTYDEVPVQRSDMISLKSRMSNFGLQRYQWLTHAWNSFQTEFKCCGVIYFTDWLEMTEMEWPPDSCCSNQYPGCARQAHY 80

                         90       100
                 ....*....|....*....|...
gi 966935379 196 EDLSDLYQEGCGKKMYSFLRGTK 218
Cdd:cd03157   81 NDLSDLYQEGCGPKIYSFIRGTK 103
Tetraspanin pfam00335
Tetraspanin family;
10-246 5.68e-27

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 103.94  E-value: 5.68e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966935379   10 LRCLLYALNLLFWLMSISVLAVSAWMRDYLNNVLTLTAEtrveeaviltYFPVVHPVMIAVCCFLIIVGMLGYCGTVKRN 89
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWLLSAFSLLLLGLSE----------ASAYIPILLIVLGAVIFLVGFLGCCGALKEN 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966935379   90 LLLLAWYFGSLLVIFCVELACGVW--TYEQELMVPVQWSDMVTLKARMTNyGLPRYRWLTHAWNFFQREFKCCGvvyftd 167
Cdd:pfam00335  71 RCLLLTYFVLLLLLFLAELAAGILafVYRDKLSGLLSNWLKKSLEDGYRD-WLDLYSCLNSALDSLQSEFGCCG------ 143

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966935379  168 wlemtemdwppdsccvrefpgcskqahqedlsdlyqeGCGKKMYSFLRgtKQLQVLRFLGISIGVTQILAMILTITLLW 246
Cdd:pfam00335 144 -------------------------------------GCKEKLLEWLR--KNLKIIGAGVIALGVIQLLGIILACCLCC 183
tetraspanin_LEL cd03127
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 123-215 2.04e-17

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


Pssm-ID: 239401 [Multi-domain]  Cd Length: 90  Bit Score: 75.62  E-value: 2.04e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966935379 123 VQWSDMVTLKARMTNYGLPRYR---WLTHAWNFFQREFKCCGVVYFTDWleMTEMDWPPDSCCVREFPGCSkqahqedlS 199
Cdd:cd03127    2 VYRDQLESLVSDTLNDAWDEYYvddDFQEAMDALQSTFECCGVNGPTDY--LDLRLLVPSSCCKGTDGNCG--------L 71

                         90
                 ....*....|....*.
gi 966935379 200 DLYQEGCGKKMYSFLR 215
Cdd:cd03127   72 NLYTEGCLEKLVDFLR 87
NET-5_like_LEL cd03165
Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. ...
 131-215 1.12e-15

Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This sub-family contains proteins similar to human tetraspan NET-5.


Pssm-ID: 239418 [Multi-domain]  Cd Length: 98  Bit Score: 71.24  E-value: 1.12e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966935379 131 LKARMTNYGLPRYRWLTHAWNFFQREFKCCGVVYFTDWLEMTEMDWPPDSCCVREFPGCSkqahQEDLSDLYQEGCGKKM 210
Cdd:cd03165   15 LKEGLELYGTRNNRGLTNAWDITQTEFRCCGVTNYTDWYEVLGENRVPDSCCQEDSQDCG----RNPTELWWKTGCYEKV 90


                 ....*
gi 966935379 211 YSFLR 215
Cdd:cd03165   91 QQWLV 95
CD151_like_LEL cd03155
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. ...
 131-214 2.17e-12

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD151strongly associates with integrins, especially alpha3beta1, alpha6beta1, alpha7beta1, and alpha6beta4; it may play roles in cell-cell adhesion, cell migration, platelet aggregation, and angiogenesis. For example, CD151 is is involved in regulation of migration of neutrophils, endothelial cells, and various tumor cell lines; it associates specifically with laminin-binding integrins and strengthens alpha6beta1 integrin-mediated adhesion to laminin-1; CD151 also specifically attenuates adhesion-dependent activation of Ras and correspdonding downstream effects, and is involved in epithelial cell-cell adhesion as a modulator of PKC- and Cdc42-dependent actin cytoskeletal reorganization.


Pssm-ID: 239408 [Multi-domain]  Cd Length: 110  Bit Score: 62.37  E-value: 2.17e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966935379 131 LKARMT-NYGLPRYRWLTHAWNFFQREFKCCGVVYFTDW-------LEMTEMDWPPDSCCVREFPGCSKQAHQEDLSDLY 202
Cdd:cd03155   15 LKRTMQeNYGQSGEEALTLTVDELQQEFKCCGSNNYTDWqdsewinSNEANGRLVPDSCCKTVVDRCGCLRDHPSNIYKV 94

                         90
                 ....*....|..
gi 966935379 203 QEGCGKKMYSFL 214
Cdd:cd03155   95 EGGCIPKLEDFL 106
CD63_LEL cd03166
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins ...
 154-215 6.97e-10

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD63 is present in platelets, neutrophils, and endothelial cells, amongst others. In platelets it associates with the integrin alphaIIBbeta3 and may modulate alphaIIbbeta3-dependent cytoskeletal reorganization.


Pssm-ID: 239419  Cd Length: 99  Bit Score: 55.17  E-value: 6.97e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966935379 154 QREFKCCGVVYFTDWLEMTEM--DWPPDSCCVREFPGCSKQAhqeDLSDLYQEGCGKKMYSFLR 215
Cdd:cd03166   36 QKDLKCCGANNYTDWENIPSLdtDSVPDSCCINVTKGCGINF---DEKVIHLEGCVTKIEGWLK 96
TM4SF2_6_like_LEL cd03161
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. ...
 135-214 1.14e-09

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 2 (TM4SF2) or Tspan-7, transmembrane 4 superfamily 6 (TM4SF6) or Tspan-6, and related proteins. TM4SF2 has been identified as involved in some forms of X-linked mental retardation.


Pssm-ID: 239414  Cd Length: 104  Bit Score: 54.67  E-value: 1.14e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966935379 135 MTNYGLPRYRwlTHAWNFFQREFKCCGVVYFTDWLemtEMDWP-----PDSCCVREfPGCSKQahqeDLSDL-------Y 202
Cdd:cd03161   19 VSNYNGDDER--SDAVDTVQRTLHCCGVENYTDWL---NSPYFlekgiPLSCCKNR-SDCSPQ----DLKNLtkaatkvY 88

                         90
                 ....*....|..
gi 966935379 203 QEGCGKKMYSFL 214
Cdd:cd03161   89 QQGCFTLVTSFM 100
TM4SF8_like_LEL cd03163
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF8_like subfamily. ...
 147-216 4.24e-09

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF8_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 8 (TM4SF8) or Tspan-3 and related proteins. Tspan-3 has been reported to form a complex with integrin beta1 and OSP/claudin-11, which may be involved in oligodendrocyte proliferation and migration.


Pssm-ID: 239416  Cd Length: 105  Bit Score: 53.20  E-value: 4.24e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966935379 147 THAWNFFQREFKCCGVVYFTDWlemTEMDW--------PPDSCCVREFPGCSKQAHQEDlsDLYQEGCGKKMYSFLRG 216
Cdd:cd03163   30 SRAVDYLQRQLQCCGIHNYTDW---ENTPWfkesknnsVPLSCCKETFTSCTGSLTQPK--DLYQEGCEAKLVKKLQE 102
uroplakin_I_like_LEL cd03156
Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. ...
 146-215 2.75e-07

Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Uroplakin Ia and Ib are components of the 16nm protein particles, which are packed hexagonally to form 2D crystals of asymmetric unit membranes, and cover the apical surface of mammalian urothelium, contributing to the urinay bladder's permeability barrier function. Uroplakins Ia and Ib are maturation facilitators. They trigger conformational changes in their single-transmembrane-domain binding partner proteins uroplakin II and IIIa, which in turn may lead to ER-exit, stabilization, and cell-surface expression.


Pssm-ID: 239409  Cd Length: 114  Bit Score: 48.30  E-value: 2.75e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966935379 146 LTHAWNFFQREFKCCGVVYFTDWLEMTEMDWP--------PDSCCVREFPGCSKQAHQEDLSD---LYQEGCGKKMYSFL 214
Cdd:cd03156   31 ITSTWNRVMIELKCCGVNGPTDFVDSTSFFRQknepnspyPESCCKRNSNSQIVDLDCPKLGSpnsYNKKGCYEKLSNPI 110


                 .
gi 966935379 215 R 215
Cdd:cd03156  111 E 111
CD37_CD82_like_LEL cd03160
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. ...
 146-214 4.84e-05

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD37 is a leukocyte-specific protein, and its restricted expression pattern suggests a role in the immune system. A regulatory role in T-cell proliferation has been suggested. CD82 is a metastasis suppressor implicated in biological processes ranging from fusion, adhesion, and migration to apoptosis and alterations of cell morphology.


Pssm-ID: 239413  Cd Length: 117  Bit Score: 41.98  E-value: 4.84e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966935379 146 LTHAWNFFQREFKCCGVVYFTDWLEMT-----EMDWPPDSCCVREFPGCSK-------QAHQEDLSDLYQEGCGKKMYSF 213
Cdd:cd03160   32 AEEAWDYVQFQLQCCGWTGPQDWTDNSliknsSEPLYPCSCCNSSATADSPrpskgfcEAPASLDWPVYQEGCMEKLQSW 111


                 .
gi 966935379 214 L 214
Cdd:cd03160  112 L 112
CD53_like_LEL cd03164
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD53_Like family. ...
 147-210 5.79e-05

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD53_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD53 is a tetraspanin of the lymphoid-myeloid lineage and has been implicated in apoptosis protection. It associates with integrin alpha4beta1. Some of the cellular responses modulated by CD53 may be mediated by JNK activation and/or via the AKT pathway.


Pssm-ID: 239417 [Multi-domain]  Cd Length: 86  Bit Score: 40.93  E-value: 5.79e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966935379 147 THAWNFFQREFKCCGVVYFTDWlemteMDWPPDSCCVrefpgcskqahqeDLSDLYQEGCGKKM 210
Cdd:cd03164   29 SEAWDMIQSNLQCCGINGTTDW-----GSGVPSSCCS-------------SDTEYKVEGCYKKL 74
TM4SF3_like_LEL cd03154
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF3_like subfamily. ...
 153-216 1.71e-04

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF3_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 3 (TM4SF3) or D6.1a and related proteins. D6.1a associates with alpha6beta4 integrin and supports cell motility, it has been ascribed a role in tumor progression and metastasis.


Pssm-ID: 239407 [Multi-domain]  Cd Length: 100  Bit Score: 40.10  E-value: 1.71e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966935379 153 FQREFKCCGVVYFTDWlemtemdWP---PDSC-CVREfpGCSKQAHQEDLSDLYQEGCGKKMYSFLRG 216
Cdd:cd03154   40 FQKELKCCGLVNGADD-------WGndiPASCnCTTT--QSDCVVAYYGGSNVYKEPCISKIKDFLKK 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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