NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1622923794|ref|XP_014989082|]
View 

FAST kinase domain-containing protein 4 isoform X1 [Macaca mulatta]

Protein Classification

FAST kinase domain-containing protein( domain architecture ID 10535844)

FAST kinase domain-containing protein similar to human Fas-activated serine/threonine (FAST) kinase that phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TBRG4-like_N cd23739
transforming growth factor beta (TGFbeta) regulator 4 (TBRG4) and similar proteins; predicted ...
 98-360 2.59e-104

transforming growth factor beta (TGFbeta) regulator 4 (TBRG4) and similar proteins; predicted alpha-helical domain N-terminal to FAST kinase-like protein, subdomain 1 (FAST_1); TBRG4 also called cell cycle progression restoration protein 2 or Fas-activated serine-threonine (FAST) kinase domain-containing protein 4, is a regulator of TGFbeta and is implicated in numerous types of cancer. It serves a role in the tumorigenesis of lung cancer via deregulation of DNA damage-inducible transcript 3 (DDIT3), caveolin 1 (CAV1), and ribonucleotide reductase regulatory subunit M2 (RRM2). This domain lies N-terminal to the FAST_1 domain, and is predicted (by AlphaFold) to be alpha-helical, with similarity to structures of members of the 6-hairpin (6 helical hairpin) clan.


:

Pssm-ID: 467932 [Multi-domain]  Cd Length: 249  Bit Score: 316.51  E-value: 2.59e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622923794  98 NHAALVLIRLSHLLSEKPKDKALLIQDARFQQLLCLLNSQINLVWHGTLSRLLRSLYALGLPRTSKELQSVEQEVRWRMR 177
Cdd:cd23739     3 NCAALAVQRLSRLVVEGRAEKDLLLEDPRFEKLCRLAENQISSLSPGSLVDLLRSLLRLGIPPNSRLLQSLENEVRWRLR 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622923794 178 KLKYKHLAFLADSCATLSQEQHSQELLTELLMHLERRWTEIEDGRTLVTIMMKVGHLSEPLMNRLEDKhslekrawqaap 257
Cdd:cd23739    83 RLSFRHLASLAESLATLQRAQEQKELLSELLKLLERRWTEIEDPRDLVTLMRIVGHLSPLLMNRLEDK------------ 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622923794 258 kvtqCLELVEQFGPDELRKVLVTLAAQSRRSVPLLRAISYHLVQKPFSLTKSVLLDLAYAYGKLGFHQTQVSQRLAADLL 337
Cdd:cd23739   151 ----ALELLEQFTLEELRRVLLTLAAQKRRSVPLLRALSYHLLQRSDQLSPKQLSDVLYACGKLNFHDTQLLEKIAADLL 226

                         250       260
                  ....*....|....*....|...
gi 1622923794 338 SLMPSLTSGEVARCAKSFALLKW 360
Cdd:cd23739   227 SKVPEMKPVLVASLLKSFGQLRW 249
FAST_2 pfam08368
FAST kinase-like protein, subdomain 2; This family represents a conserved region of eukaryotic ...
 467-552 1.33e-29

FAST kinase-like protein, subdomain 2; This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This subdomain is often found associated with the FAST kinase-like protein, subdomain 2.


:

Pssm-ID: 462448  Cd Length: 89  Bit Score: 112.28  E-value: 1.33e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622923794 467 FQKLLHINATAMLEHPEYSGPLLPASAVAP---RPSALDRKVTPLQKELQETLKGLLGSADRGSLEVATQYGWVLDAEVL 543
Cdd:pfam08368   1 RLKLLQLNATVCLECPEYKGPWLPPKYCVKsfkVPLSSSKKKSPLQKEVLEALKELLGGENYFRSNVLTPYGYTIDFECK 80


                  ....*....
gi 1622923794 544 LDSDGQFLP 552
Cdd:pfam08368  81 LDKDGKPLP 89
FAST_1 pfam06743
FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic ...
 385-456 2.18e-22

FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This region is often found immediately N-terminal to the FAST kinase-like protein, subdomain 2.


:

Pssm-ID: 461999 [Multi-domain]  Cd Length: 72  Bit Score: 91.01  E-value: 2.18e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622923794 385 LCSVLLAFARLNFHPDQEDEFFSLVHEKLGSELPGLEPALQVDLVWALCVLQQAREAELQAVLHPEFHIQFL 456
Cdd:pfam06743   1 LLSLLLPFARLNYLPPNAEEFFEKLESVLESYLSSFSPELLLDLVWSLCVLGRFPEALLNKVLSPDFLQKLL 72
RAP smart00952
This domain is found in various eukaryotic species, particularly in apicomplexans; In ...
 579-636 3.20e-14

This domain is found in various eukaryotic species, particularly in apicomplexans; In Plasmodium falciparum, the domain is found in proteins that are important in various parasite-host cell interactions. It is thought to be an RNA-binding domain.


:

Pssm-ID: 214932  Cd Length: 58  Bit Score: 67.26  E-value: 3.20e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622923794  579 FLRWEFPNFSTRSKDLLGRFVLARRHILAAGFLIVDVPFYEWLELKSEWQKGAYLKDK 636
Cdd:smart00952   1 IEVDGPSHFCRNSRHLLGRLALKKRHLEALGYKVISIPYYEWNKLKSEDEKVEYLKEK 58
 
Name Accession Description Interval E-value
TBRG4-like_N cd23739
transforming growth factor beta (TGFbeta) regulator 4 (TBRG4) and similar proteins; predicted ...
 98-360 2.59e-104

transforming growth factor beta (TGFbeta) regulator 4 (TBRG4) and similar proteins; predicted alpha-helical domain N-terminal to FAST kinase-like protein, subdomain 1 (FAST_1); TBRG4 also called cell cycle progression restoration protein 2 or Fas-activated serine-threonine (FAST) kinase domain-containing protein 4, is a regulator of TGFbeta and is implicated in numerous types of cancer. It serves a role in the tumorigenesis of lung cancer via deregulation of DNA damage-inducible transcript 3 (DDIT3), caveolin 1 (CAV1), and ribonucleotide reductase regulatory subunit M2 (RRM2). This domain lies N-terminal to the FAST_1 domain, and is predicted (by AlphaFold) to be alpha-helical, with similarity to structures of members of the 6-hairpin (6 helical hairpin) clan.


Pssm-ID: 467932 [Multi-domain]  Cd Length: 249  Bit Score: 316.51  E-value: 2.59e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622923794  98 NHAALVLIRLSHLLSEKPKDKALLIQDARFQQLLCLLNSQINLVWHGTLSRLLRSLYALGLPRTSKELQSVEQEVRWRMR 177
Cdd:cd23739     3 NCAALAVQRLSRLVVEGRAEKDLLLEDPRFEKLCRLAENQISSLSPGSLVDLLRSLLRLGIPPNSRLLQSLENEVRWRLR 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622923794 178 KLKYKHLAFLADSCATLSQEQHSQELLTELLMHLERRWTEIEDGRTLVTIMMKVGHLSEPLMNRLEDKhslekrawqaap 257
Cdd:cd23739    83 RLSFRHLASLAESLATLQRAQEQKELLSELLKLLERRWTEIEDPRDLVTLMRIVGHLSPLLMNRLEDK------------ 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622923794 258 kvtqCLELVEQFGPDELRKVLVTLAAQSRRSVPLLRAISYHLVQKPFSLTKSVLLDLAYAYGKLGFHQTQVSQRLAADLL 337
Cdd:cd23739   151 ----ALELLEQFTLEELRRVLLTLAAQKRRSVPLLRALSYHLLQRSDQLSPKQLSDVLYACGKLNFHDTQLLEKIAADLL 226

                         250       260
                  ....*....|....*....|...
gi 1622923794 338 SLMPSLTSGEVARCAKSFALLKW 360
Cdd:cd23739   227 SKVPEMKPVLVASLLKSFGQLRW 249
FAST_2 pfam08368
FAST kinase-like protein, subdomain 2; This family represents a conserved region of eukaryotic ...
 467-552 1.33e-29

FAST kinase-like protein, subdomain 2; This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This subdomain is often found associated with the FAST kinase-like protein, subdomain 2.


Pssm-ID: 462448  Cd Length: 89  Bit Score: 112.28  E-value: 1.33e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622923794 467 FQKLLHINATAMLEHPEYSGPLLPASAVAP---RPSALDRKVTPLQKELQETLKGLLGSADRGSLEVATQYGWVLDAEVL 543
Cdd:pfam08368   1 RLKLLQLNATVCLECPEYKGPWLPPKYCVKsfkVPLSSSKKKSPLQKEVLEALKELLGGENYFRSNVLTPYGYTIDFECK 80


                  ....*....
gi 1622923794 544 LDSDGQFLP 552
Cdd:pfam08368  81 LDKDGKPLP 89
FAST_1 pfam06743
FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic ...
 385-456 2.18e-22

FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This region is often found immediately N-terminal to the FAST kinase-like protein, subdomain 2.


Pssm-ID: 461999 [Multi-domain]  Cd Length: 72  Bit Score: 91.01  E-value: 2.18e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622923794 385 LCSVLLAFARLNFHPDQEDEFFSLVHEKLGSELPGLEPALQVDLVWALCVLQQAREAELQAVLHPEFHIQFL 456
Cdd:pfam06743   1 LLSLLLPFARLNYLPPNAEEFFEKLESVLESYLSSFSPELLLDLVWSLCVLGRFPEALLNKVLSPDFLQKLL 72
RAP smart00952
This domain is found in various eukaryotic species, particularly in apicomplexans; In ...
 579-636 3.20e-14

This domain is found in various eukaryotic species, particularly in apicomplexans; In Plasmodium falciparum, the domain is found in proteins that are important in various parasite-host cell interactions. It is thought to be an RNA-binding domain.


Pssm-ID: 214932  Cd Length: 58  Bit Score: 67.26  E-value: 3.20e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622923794  579 FLRWEFPNFSTRSKDLLGRFVLARRHILAAGFLIVDVPFYEWLELKSEWQKGAYLKDK 636
Cdd:smart00952   1 IEVDGPSHFCRNSRHLLGRLALKKRHLEALGYKVISIPYYEWNKLKSEDEKVEYLKEK 58
RAP pfam08373
RAP domain; This domain is found in various eukaryotic species, where it is found in proteins ...
 582-636 7.20e-12

RAP domain; This domain is found in various eukaryotic species, where it is found in proteins that are important in various parasite-host cell interactions. It is thought to be an RNA-binding domain. The domain is involved in plant defence in response to bacterial infection.


Pssm-ID: 429953  Cd Length: 58  Bit Score: 60.67  E-value: 7.20e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1622923794 582 WEFPNFSTRSKDLLGRFVLARRHILAAGFLIVDVPFYEWLELKSEWQKGAYLKDK 636
Cdd:pfam08373   4 DGPSHFYRNSKQLTGSTKLKHRLLSALGYKVISIPYYEWNQLKTKEEKVEYLKKK 58
 
Name Accession Description Interval E-value
TBRG4-like_N cd23739
transforming growth factor beta (TGFbeta) regulator 4 (TBRG4) and similar proteins; predicted ...
 98-360 2.59e-104

transforming growth factor beta (TGFbeta) regulator 4 (TBRG4) and similar proteins; predicted alpha-helical domain N-terminal to FAST kinase-like protein, subdomain 1 (FAST_1); TBRG4 also called cell cycle progression restoration protein 2 or Fas-activated serine-threonine (FAST) kinase domain-containing protein 4, is a regulator of TGFbeta and is implicated in numerous types of cancer. It serves a role in the tumorigenesis of lung cancer via deregulation of DNA damage-inducible transcript 3 (DDIT3), caveolin 1 (CAV1), and ribonucleotide reductase regulatory subunit M2 (RRM2). This domain lies N-terminal to the FAST_1 domain, and is predicted (by AlphaFold) to be alpha-helical, with similarity to structures of members of the 6-hairpin (6 helical hairpin) clan.


Pssm-ID: 467932 [Multi-domain]  Cd Length: 249  Bit Score: 316.51  E-value: 2.59e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622923794  98 NHAALVLIRLSHLLSEKPKDKALLIQDARFQQLLCLLNSQINLVWHGTLSRLLRSLYALGLPRTSKELQSVEQEVRWRMR 177
Cdd:cd23739     3 NCAALAVQRLSRLVVEGRAEKDLLLEDPRFEKLCRLAENQISSLSPGSLVDLLRSLLRLGIPPNSRLLQSLENEVRWRLR 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622923794 178 KLKYKHLAFLADSCATLSQEQHSQELLTELLMHLERRWTEIEDGRTLVTIMMKVGHLSEPLMNRLEDKhslekrawqaap 257
Cdd:cd23739    83 RLSFRHLASLAESLATLQRAQEQKELLSELLKLLERRWTEIEDPRDLVTLMRIVGHLSPLLMNRLEDK------------ 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622923794 258 kvtqCLELVEQFGPDELRKVLVTLAAQSRRSVPLLRAISYHLVQKPFSLTKSVLLDLAYAYGKLGFHQTQVSQRLAADLL 337
Cdd:cd23739   151 ----ALELLEQFTLEELRRVLLTLAAQKRRSVPLLRALSYHLLQRSDQLSPKQLSDVLYACGKLNFHDTQLLEKIAADLL 226

                         250       260
                  ....*....|....*....|...
gi 1622923794 338 SLMPSLTSGEVARCAKSFALLKW 360
Cdd:cd23739   227 SKVPEMKPVLVASLLKSFGQLRW 249
FAST_2 pfam08368
FAST kinase-like protein, subdomain 2; This family represents a conserved region of eukaryotic ...
 467-552 1.33e-29

FAST kinase-like protein, subdomain 2; This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This subdomain is often found associated with the FAST kinase-like protein, subdomain 2.


Pssm-ID: 462448  Cd Length: 89  Bit Score: 112.28  E-value: 1.33e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622923794 467 FQKLLHINATAMLEHPEYSGPLLPASAVAP---RPSALDRKVTPLQKELQETLKGLLGSADRGSLEVATQYGWVLDAEVL 543
Cdd:pfam08368   1 RLKLLQLNATVCLECPEYKGPWLPPKYCVKsfkVPLSSSKKKSPLQKEVLEALKELLGGENYFRSNVLTPYGYTIDFECK 80


                  ....*....
gi 1622923794 544 LDSDGQFLP 552
Cdd:pfam08368  81 LDKDGKPLP 89
FAST_1 pfam06743
FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic ...
 385-456 2.18e-22

FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This region is often found immediately N-terminal to the FAST kinase-like protein, subdomain 2.


Pssm-ID: 461999 [Multi-domain]  Cd Length: 72  Bit Score: 91.01  E-value: 2.18e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622923794 385 LCSVLLAFARLNFHPDQEDEFFSLVHEKLGSELPGLEPALQVDLVWALCVLQQAREAELQAVLHPEFHIQFL 456
Cdd:pfam06743   1 LLSLLLPFARLNYLPPNAEEFFEKLESVLESYLSSFSPELLLDLVWSLCVLGRFPEALLNKVLSPDFLQKLL 72
RAP smart00952
This domain is found in various eukaryotic species, particularly in apicomplexans; In ...
 579-636 3.20e-14

This domain is found in various eukaryotic species, particularly in apicomplexans; In Plasmodium falciparum, the domain is found in proteins that are important in various parasite-host cell interactions. It is thought to be an RNA-binding domain.


Pssm-ID: 214932  Cd Length: 58  Bit Score: 67.26  E-value: 3.20e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622923794  579 FLRWEFPNFSTRSKDLLGRFVLARRHILAAGFLIVDVPFYEWLELKSEWQKGAYLKDK 636
Cdd:smart00952   1 IEVDGPSHFCRNSRHLLGRLALKKRHLEALGYKVISIPYYEWNKLKSEDEKVEYLKEK 58
RAP pfam08373
RAP domain; This domain is found in various eukaryotic species, where it is found in proteins ...
 582-636 7.20e-12

RAP domain; This domain is found in various eukaryotic species, where it is found in proteins that are important in various parasite-host cell interactions. It is thought to be an RNA-binding domain. The domain is involved in plant defence in response to bacterial infection.


Pssm-ID: 429953  Cd Length: 58  Bit Score: 60.67  E-value: 7.20e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1622923794 582 WEFPNFSTRSKDLLGRFVLARRHILAAGFLIVDVPFYEWLELKSEWQKGAYLKDK 636
Cdd:pfam08373   4 DGPSHFYRNSKQLTGSTKLKHRLLSALGYKVISIPYYEWNQLKTKEEKVEYLKKK 58
RESC6-like cd23735
RNA-editing substrate-binding complex subunit 6 (RESC6) and related proteins; RESC6 (GRBC6, ...
 146-396 1.10e-04

RNA-editing substrate-binding complex subunit 6 (RESC6) and related proteins; RESC6 (GRBC6, MRB3010) is a component of the RNA-editing substrate-binding complex (RESC), that is composed of about 20 components and is involved in kinetoplast RNA processing. The mitochondrial DNA of Trypanosomatids, known as the kinetoplast DNA (kDNA or mtDNA), consists of a network of dozens of maxicircles and thousands of minicircles concatenated together. Maxicircles are equivalent to other eukaryotic mitochondrial DNAs, while minicircles encode guide RNAs (gRNAs) involved in U-insertion/deletion editing processes exclusive of Trypanosomatids that produce the maturation of the maxicircle-encoded transcripts. Although most gRNAs are encoded by minicircles, varying numbers of maxicircle-encoded gRNAs have been identified in kinetoplastids species. Trypanosoma brucei maxicircles encode 9S and 12S rRNAs, two gRNAs, two ribosomal proteins and 16 subunits of respiratory complexes. 12 of the 18 maxicircle genes are present as cryptogenes whose transcripts require U-insertion/deletion editing, mediated by gRNAs, to restore a protein-coding capacity. RESC interacts with two other complexes, the RNA-editing helicase 2 complex (REH2C) and RNA-editing catalytic complex (RECC) to form an assembly (editosome/holoenzyme) that carries out U-insertion/deletion mRNA editing. RESC6 is predicted (by AlphaFold) to adopt an all-helical structure with a disordered region at the N-terminus. The helical structure that is predicted with high confidence resembles Armadillo (ARM)/beta-catenin-like repeats. ARM repeats have been implicated in mediating protein-protein interactions.


Pssm-ID: 467928 [Multi-domain]  Cd Length: 299  Bit Score: 44.61  E-value: 1.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622923794 146 LSRLLRSLYALGLPRTSKELQSVEQEVrwrMRKLKYKHLAFLADSCATLSQEQHSQELltELLMHLERRWTEIEDGRTLV 225
Cdd:cd23735    31 LAAALRYFGMKSDARKTREFVSLAPTA---DKALDLASLAAVVHACLTLRSEDLREVI--FTAARKLRENAKTLDAVSVA 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622923794 226 TI---MMKVGHLSEPLMNRLEDkhslekRAWQAAPKvtqclelveqfGPDELRKVLVTLAAQSR---RSVPLLRAISYHL 299
Cdd:cd23735   106 VLlsaYARTGVHHDALFEALSD------RVVTLAKD-----------GRFPLAHIVNVASALSRvrfRDEALFGVLRDRA 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622923794 300 VQKPFSLTKSVLLDLAYAYGKLGFHQTQVSQRLAADLLSLMPSLTSGEVARCAKSFALLKWLNLPLYEAFAQHVLNRAQD 379
Cdd:cd23735   169 LRLREQAPPIELATILDAFARLGLGDERLFKELAQRALEVLDEMNAPLVASVLSAFAKAGRRHDELFGVLAERAVELADT 248

                         250
                  ....*....|....*..
gi 1622923794 380 ITVPHLCSVLLAFARLN 396
Cdd:cd23735   249 FDARSIAKTLSAFARAG 265
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH