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Conserved domains on  [gi|966931099|ref|XP_014988247|]
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keratin-associated protein 10-1 isoform X3 [Macaca mulatta]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Keratin_B2 super family cl37504
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 22-199 2.97e-11

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


The actual alignment was detected with superfamily member pfam01500:

Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 60.19  E-value: 2.97e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966931099   22 CPESCCEPPCCAPSCCTPASCLTLVCTPVSCVSRpCCQVACESSpCQSGCtssCIPSCCQQSSCQPACCTSSPCQQACCV 101
Cdd:pfam01500  20 CGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSS-CCRPTCQPC-CQTSC---CQPTCCQTSSCQTGCGGIGYGQEGSSG 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966931099  102 PVCCKPVCCKSVCCVPTCsgdsssccqqsscqpacctsspCQQSCCVPVCCKPsvccvpicsggsiSCCQQSSCQPACCT 181
Cdd:pfam01500  95 AVSSRTRWCRPDCRVEGT----------------------CLPPCCVVSCTPP-------------TCCQLHHAQASCCR 139

                         170
                  ....*....|....*...
gi 966931099  182 SSPCQQSCCVPVCCKPVC 199
Cdd:pfam01500 140 PSYCGQSCCRPACCCQCS 157
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
189-245 5.19e-06

Keratin, high sulfur B2 protein;


:

Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 42.37  E-value: 5.19e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 966931099  189 CCVPVCCKPVCCKPvsclpicsgastSCCQQSSCQPACCTTSCCRPSSSVSLLCRPV 245
Cdd:pfam13885   1 CCQPSCCQPSCCQP------------SCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 22-199 2.97e-11

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 60.19  E-value: 2.97e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966931099   22 CPESCCEPPCCAPSCCTPASCLTLVCTPVSCVSRpCCQVACESSpCQSGCtssCIPSCCQQSSCQPACCTSSPCQQACCV 101
Cdd:pfam01500  20 CGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSS-CCRPTCQPC-CQTSC---CQPTCCQTSSCQTGCGGIGYGQEGSSG 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966931099  102 PVCCKPVCCKSVCCVPTCsgdsssccqqsscqpacctsspCQQSCCVPVCCKPsvccvpicsggsiSCCQQSSCQPACCT 181
Cdd:pfam01500  95 AVSSRTRWCRPDCRVEGT----------------------CLPPCCVVSCTPP-------------TCCQLHHAQASCCR 139

                         170
                  ....*....|....*...
gi 966931099  182 SSPCQQSCCVPVCCKPVC 199
Cdd:pfam01500 140 PSYCGQSCCRPACCCQCS 157
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
189-245 5.19e-06

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 42.37  E-value: 5.19e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 966931099  189 CCVPVCCKPVCCKPvsclpicsgastSCCQQSSCQPACCTTSCCRPSSSVSLLCRPV 245
Cdd:pfam13885   1 CCQPSCCQPSCCQP------------SCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 22-199 2.97e-11

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 60.19  E-value: 2.97e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966931099   22 CPESCCEPPCCAPSCCTPASCLTLVCTPVSCVSRpCCQVACESSpCQSGCtssCIPSCCQQSSCQPACCTSSPCQQACCV 101
Cdd:pfam01500  20 CGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSS-CCRPTCQPC-CQTSC---CQPTCCQTSSCQTGCGGIGYGQEGSSG 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966931099  102 PVCCKPVCCKSVCCVPTCsgdsssccqqsscqpacctsspCQQSCCVPVCCKPsvccvpicsggsiSCCQQSSCQPACCT 181
Cdd:pfam01500  95 AVSSRTRWCRPDCRVEGT----------------------CLPPCCVVSCTPP-------------TCCQLHHAQASCCR 139

                         170
                  ....*....|....*...
gi 966931099  182 SSPCQQSCCVPVCCKPVC 199
Cdd:pfam01500 140 PSYCGQSCCRPACCCQCS 157
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 109-251 3.93e-11

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 59.80  E-value: 3.93e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966931099  109 CCKSVCCVPTCSgdSSSCCQQSSCQPACCTSSPCQQSCCVPVCCKPSVCCVPICSGGSISCCQQSSCQPACCTSSPCQQS 188
Cdd:pfam01500   4 CGTSFCGFPTCS--TGGTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTCQPCCQTSCCQPTCCQTSSCQTG 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966931099  189 C---------------CVPVCCKPVCCKPVSCLPICsgASTSCCQQSSCQPACCTTSCCRPSSSVSLLCRPVCSRPAC 251
Cdd:pfam01500  82 CggigygqegssgavsSRTRWCRPDCRVEGTCLPPC--CVVSCTPPTCCQLHHAQASCCRPSYCGQSCCRPACCCQCS 157
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
74-118 2.69e-09

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 51.61  E-value: 2.69e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 966931099   74 SCIPSCCQQSSCQPACCTSSPCQQACCVPVCCKPVCCKSVCCVPT 118
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
79-119 1.21e-08

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 49.69  E-value: 1.21e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 966931099   79 CCQQSSCQPACCTSSPCQQACCVPVCCKPVCCKSVCCVPTC 119
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSC 41
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
169-209 5.72e-08

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 47.76  E-value: 5.72e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 966931099  169 CCQQSSCQPACCTSSPCQQSCCVPVCCKPVCCKPVSCLPIC 209
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSC 41
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
168-208 1.10e-07

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 46.99  E-value: 1.10e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 966931099  168 SCCQQSSCQPACCTSSPCQQSCCVPVCCKPVCCKPVSCLPI 208
Cdd:pfam13885   5 SCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
72-113 1.38e-07

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 46.99  E-value: 1.38e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 966931099   72 TSSCIPSCCQQSSCQPACCTSSPCQQACCVPVCCKPVCCKSV 113
Cdd:pfam13885   4 PSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
189-245 5.19e-06

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 42.37  E-value: 5.19e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 966931099  189 CCVPVCCKPVCCKPvsclpicsgastSCCQQSSCQPACCTTSCCRPSSSVSLLCRPV 245
Cdd:pfam13885   1 CCQPSCCQPSCCQP------------SCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
104-157 3.00e-05

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 40.44  E-value: 3.00e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 966931099  104 CCKPVCCKSVCCVPTCSGdsssccqqsscqPACCTSSPCQQSCCVPVCCKPSVC 157
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQ------------PSCCQPSCCQPSCCRPSCCRSSCC 42
PMG pfam05287
PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and ...
 10-151 3.93e-05

PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and PMG2). PMG1 and 2 contain characteriztic repeats reminiscent of the keratin-associated proteins (KAPs). Both genes are expressed in growing hair follicles in skin as well as in sebaceous and eccrine sweat glands. Interestingly, expression is also detected in the mammary epithelium where it is limited to the onset of the pubertal growth phase and is independent of ovarian hormones. Their broad, developmentally controlled expression pattern, together with their unique amino acid composition, demonstrate that pmg-1 and pmg-2 constitute a novel KAP gene family participating in the differentiation of all epithelial cells forming the epidermal appendages.


Pssm-ID: 283053 [Multi-domain]  Cd Length: 180  Bit Score: 42.88  E-value: 3.93e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966931099   10 SSAYSDSWQVDDCPESCCEPPCCAPSCCTPASCLTLVCTPVSCVSRpcCQVACESSPCQSGCTSSCIPSCCQQSSCQPAC 89
Cdd:pfam05287  44 SSCQLGSSLRDNCQETCGEPTSCQTSSCEPCTSSTSYCVPSPCQRS--CYSPRTSCVCSPCQTTSAGSLGFGSSSCQSLG 121

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966931099   90 CTSSPCQQACCVPVCCKPVCCKSVCCVPTCSGdsssccqQSSCQPACCTSSPCQQSCCVPVC 151
Cdd:pfam05287 122 YGSNSCQPLGCGSSGFRPLGCLSKGFQSLGYG-------SSFCRPSYVSSRSYQPSCFRPSC 176
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
194-250 1.40e-04

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 38.52  E-value: 1.40e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 966931099  194 CCKPVCCKPvsclpicsgastSCCQQSSCQPACCTTSCCRPSSSVSLLCRPVCSRPA 250
Cdd:pfam13885   1 CCQPSCCQP------------SCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
216-251 2.10e-04

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 38.13  E-value: 2.10e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 966931099  216 CCQQSSCQPACCTTSCCRPSSSVSLLCRPVCSRPAC 251
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSC 36
PMG pfam05287
PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and ...
 80-231 8.07e-04

PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and PMG2). PMG1 and 2 contain characteriztic repeats reminiscent of the keratin-associated proteins (KAPs). Both genes are expressed in growing hair follicles in skin as well as in sebaceous and eccrine sweat glands. Interestingly, expression is also detected in the mammary epithelium where it is limited to the onset of the pubertal growth phase and is independent of ovarian hormones. Their broad, developmentally controlled expression pattern, together with their unique amino acid composition, demonstrate that pmg-1 and pmg-2 constitute a novel KAP gene family participating in the differentiation of all epithelial cells forming the epidermal appendages.


Pssm-ID: 283053 [Multi-domain]  Cd Length: 180  Bit Score: 39.03  E-value: 8.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966931099   80 CQQSSCQPACCTSSPCQQACCVPVCCKPVCCKSVCCvptcsgdsssccqqsscQPACCTSSPCQQSCCVPVCCKPSVCCV 159
Cdd:pfam05287  41 CSPSSCQLGSSLRDNCQETCGEPTSCQTSSCEPCTS-----------------STSYCVPSPCQRSCYSPRTSCVCSPCQ 103

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966931099  160 PICSGGSISCcqQSSCQPACCTSSPCQQSCCVPVCCKPVCCKPVSCLPICSGAST---SCCQQSSCQPACCTTSC 231
Cdd:pfam05287 104 TTSAGSLGFG--SSSCQSLGYGSNSCQPLGCGSSGFRPLGCLSKGFQSLGYGSSFcrpSYVSSRSYQPSCFRPSC 176
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
26-108 6.10e-03

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 33.89  E-value: 6.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966931099   26 CCEPPCCAPSCCTpascltlvctpvscvsrpccqvacesspcqsgctssciPSCCQQSSCQPACCTSSPCQQACCVPVCC 105
Cdd:pfam13885   1 CCQPSCCQPSCCQ--------------------------------------PSCCQPSCCQPSCCQPSCCRPSCCRSSCC 42


                  ...
gi 966931099  106 KPV 108
Cdd:pfam13885  43 QPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
22-65 7.28e-03

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 33.51  E-value: 7.28e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 966931099   22 CPESCCEPPCCAPSCCTPASCLTLVCTPVSCVSRPCCQVACESS 65
Cdd:pfam13885   2 CQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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