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Conserved domains on  [gi|1622920110|ref|XP_014988164|]
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collagen alpha-2(VI) chain isoform X2 [Macaca mulatta]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
vWA_collagen_alpha_1-VI-type cd01480
VWA_collagen alpha(VI) type: The extracellular matrix represents a complex alloy of variable ...
612-803 1.75e-68

VWA_collagen alpha(VI) type: The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different collagen types identified thus far. Collagens are centrally involved in the formation of fibrillar and microfibrillar networks of the extracellular matrix, basement membranes as well as other structures of the extracellular matrix. Some collagens have about 15-18 vWA domains in them. The VWA domains present in these collagens mediate protein-protein interactions.


:

Pssm-ID: 238757 [Multi-domain]  Cd Length: 186  Bit Score: 225.73  E-value: 1.75e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 612 GALDVVFVIDSSESIGYTNFTLEKNFVINVVNRLGAIAKDPKSETGTRVGVVQYSHEGTFEAIQLDDERidSLSSFKEAV 691
Cdd:cd01480     1 GPVDITFVLDSSESVGLQNFDITKNFVKRVAERFLKDYYRKDPAGSWRVGVVQYSDQQEVEAGFLRDIR--NYTSLKEAV 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 692 KNLEWIAGGTWTPSALKFAYDRLIkESRRQKTRVFAVVITDGRHDPRDDDLNLRALCDRDvtvtAIGIGDMFHE--KHES 769
Cdd:cd01480    79 DNLEYIGGGTFTDCALKYATEQLL-EGSHQKENKFLLVITDGHSDGSPDGGIEKAVNEAD----HLGIKIFFVAvgSQNE 153
                         170       180       190
                  ....*....|....*....|....*....|....
gi 1622920110 770 ENLYSIACDKPQQvRNMTLFSDLVAEKFIDDMED 803
Cdd:cd01480   154 EPLSRIACDGKSA-LYRENFAELLWSFFIDDETA 186
vWA_collagen_alpha_1-VI-type cd01480
VWA_collagen alpha(VI) type: The extracellular matrix represents a complex alloy of variable ...
43-231 1.48e-61

VWA_collagen alpha(VI) type: The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different collagen types identified thus far. Collagens are centrally involved in the formation of fibrillar and microfibrillar networks of the extracellular matrix, basement membranes as well as other structures of the extracellular matrix. Some collagens have about 15-18 vWA domains in them. The VWA domains present in these collagens mediate protein-protein interactions.


:

Pssm-ID: 238757 [Multi-domain]  Cd Length: 186  Bit Score: 206.85  E-value: 1.48e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110  43 CPIHVYFVLDTSESVTMQsPTDILLFHMKQFVPQFISQlqneFYLDQVALSWRYGGLHFSDQVEVFSPPG---SDRASFI 119
Cdd:cd01480     1 GPVDITFVLDSSESVGLQ-NFDITKNFVKRVAERFLKD----YYRKDPAGSWRVGVVQYSDQQEVEAGFLrdiRNYTSLK 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 120 KSLQGISSFRRGTFTDCALANMTEQIRQHGTKGTVHFAVVITDGHVTGSPCGGIKLQAERAREEGIRLFAVAPNRNLKEQ 199
Cdd:cd01480    76 EAVDNLEYIGGGTFTDCALKYATEQLLEGSHQKENKFLLVITDGHSDGSPDGGIEKAVNEADHLGIKIFFVAVGSQNEEP 155
                         170       180       190
                  ....*....|....*....|....*....|...
gi 1622920110 200 gLRDIASTPHE-LYRNDYATMLPDsTEIDQDTI 231
Cdd:cd01480   156 -LSRIACDGKSaLYRENFAELLWS-FFIDDETA 186
gly_rich_SclB super family cl45768
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
255-513 9.70e-43

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


The actual alignment was detected with superfamily member NF038329:

Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 162.00  E-value: 9.70e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 255 PGPPGPKGYRGQKGAKGNMGEPGEPGQKGRQGDPGIEGPIGFPGPKGVPGFKGEKGEfgaDGRKGAPGLAGKNGTDGQKG 334
Cdd:NF038329  122 PGPAGPAGPAGEQGPRGDRGETGPAGPAGPPGPQGERGEKGPAGPQGEAGPQGPAGK---DGEAGAKGPAGEKGPQGPRG 198
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 335 KLGRIGPPGCKGDPGNRGPDGYPGEAGSPGERGDqggkgdpgrpgrrgppgdiGAKGSKGYQGNNGAPGSHGvkgakggp 414
Cdd:NF038329  199 ETGPAGEQGPAGPAGPDGEAGPAGEDGPAGPAGD-------------------GQQGPDGDPGPTGEDGPQG-------- 251
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 415 gprgpkgepgRRGDPGTKGSPGSDGPKGEKGDPGPEGPRGLAGEVGNKGAKGDRGLPGPRGPQGALGEPGNQGSRGDPGD 494
Cdd:NF038329  252 ----------PDGPAGKDGPRGDRGEAGPDGPDGKDGERGPVGPAGKDGQNGKDGLPGKDGKDGQNGKDGLPGKDGKDGQ 321
                         250
                  ....*....|....*....
gi 1622920110 495 AGPRGDSGQPGPKGDPGRP 513
Cdd:NF038329  322 PGKDGLPGKDGKDGQPGKP 340
Collagen pfam01391
Collagen triple helix repeat (20 copies); Members of this family belong to the collagen ...
487-556 1.05e-06

Collagen triple helix repeat (20 copies); Members of this family belong to the collagen superfamily. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The alignment contains 20 copies of the G-X-Y repeat that forms a triple helix. The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxy-proline. Collagens are post translationally modified by proline hydroxylase to form the hydroxy-proline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure. The family includes bacterial collagen-like triple-helix repeat proteins.


:

Pssm-ID: 460189 [Multi-domain]  Cd Length: 57  Bit Score: 46.33  E-value: 1.05e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 487 GSRGDPGDAGPRGDSGQPGPKGDPGRPGfsYPGPRGAPGdkgepgprgpeggrgdfgLKGEPGRKGEKGE 556
Cdd:pfam01391   1 GPPGPPGPPGPPGPPGPPGPPGPPGPPG--PPGEPGPPG------------------PPGPPGPPGPPGA 50
 
Name Accession Description Interval E-value
vWA_collagen_alpha_1-VI-type cd01480
VWA_collagen alpha(VI) type: The extracellular matrix represents a complex alloy of variable ...
612-803 1.75e-68

VWA_collagen alpha(VI) type: The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different collagen types identified thus far. Collagens are centrally involved in the formation of fibrillar and microfibrillar networks of the extracellular matrix, basement membranes as well as other structures of the extracellular matrix. Some collagens have about 15-18 vWA domains in them. The VWA domains present in these collagens mediate protein-protein interactions.


Pssm-ID: 238757 [Multi-domain]  Cd Length: 186  Bit Score: 225.73  E-value: 1.75e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 612 GALDVVFVIDSSESIGYTNFTLEKNFVINVVNRLGAIAKDPKSETGTRVGVVQYSHEGTFEAIQLDDERidSLSSFKEAV 691
Cdd:cd01480     1 GPVDITFVLDSSESVGLQNFDITKNFVKRVAERFLKDYYRKDPAGSWRVGVVQYSDQQEVEAGFLRDIR--NYTSLKEAV 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 692 KNLEWIAGGTWTPSALKFAYDRLIkESRRQKTRVFAVVITDGRHDPRDDDLNLRALCDRDvtvtAIGIGDMFHE--KHES 769
Cdd:cd01480    79 DNLEYIGGGTFTDCALKYATEQLL-EGSHQKENKFLLVITDGHSDGSPDGGIEKAVNEAD----HLGIKIFFVAvgSQNE 153
                         170       180       190
                  ....*....|....*....|....*....|....
gi 1622920110 770 ENLYSIACDKPQQvRNMTLFSDLVAEKFIDDMED 803
Cdd:cd01480   154 EPLSRIACDGKSA-LYRENFAELLWSFFIDDETA 186
vWA_collagen_alpha_1-VI-type cd01480
VWA_collagen alpha(VI) type: The extracellular matrix represents a complex alloy of variable ...
43-231 1.48e-61

VWA_collagen alpha(VI) type: The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different collagen types identified thus far. Collagens are centrally involved in the formation of fibrillar and microfibrillar networks of the extracellular matrix, basement membranes as well as other structures of the extracellular matrix. Some collagens have about 15-18 vWA domains in them. The VWA domains present in these collagens mediate protein-protein interactions.


Pssm-ID: 238757 [Multi-domain]  Cd Length: 186  Bit Score: 206.85  E-value: 1.48e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110  43 CPIHVYFVLDTSESVTMQsPTDILLFHMKQFVPQFISQlqneFYLDQVALSWRYGGLHFSDQVEVFSPPG---SDRASFI 119
Cdd:cd01480     1 GPVDITFVLDSSESVGLQ-NFDITKNFVKRVAERFLKD----YYRKDPAGSWRVGVVQYSDQQEVEAGFLrdiRNYTSLK 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 120 KSLQGISSFRRGTFTDCALANMTEQIRQHGTKGTVHFAVVITDGHVTGSPCGGIKLQAERAREEGIRLFAVAPNRNLKEQ 199
Cdd:cd01480    76 EAVDNLEYIGGGTFTDCALKYATEQLLEGSHQKENKFLLVITDGHSDGSPDGGIEKAVNEADHLGIKIFFVAVGSQNEEP 155
                         170       180       190
                  ....*....|....*....|....*....|...
gi 1622920110 200 gLRDIASTPHE-LYRNDYATMLPDsTEIDQDTI 231
Cdd:cd01480   156 -LSRIACDGKSaLYRENFAELLWS-FFIDDETA 186
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
255-513 9.70e-43

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 162.00  E-value: 9.70e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 255 PGPPGPKGYRGQKGAKGNMGEPGEPGQKGRQGDPGIEGPIGFPGPKGVPGFKGEKGEfgaDGRKGAPGLAGKNGTDGQKG 334
Cdd:NF038329  122 PGPAGPAGPAGEQGPRGDRGETGPAGPAGPPGPQGERGEKGPAGPQGEAGPQGPAGK---DGEAGAKGPAGEKGPQGPRG 198
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 335 KLGRIGPPGCKGDPGNRGPDGYPGEAGSPGERGDqggkgdpgrpgrrgppgdiGAKGSKGYQGNNGAPGSHGvkgakggp 414
Cdd:NF038329  199 ETGPAGEQGPAGPAGPDGEAGPAGEDGPAGPAGD-------------------GQQGPDGDPGPTGEDGPQG-------- 251
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 415 gprgpkgepgRRGDPGTKGSPGSDGPKGEKGDPGPEGPRGLAGEVGNKGAKGDRGLPGPRGPQGALGEPGNQGSRGDPGD 494
Cdd:NF038329  252 ----------PDGPAGKDGPRGDRGEAGPDGPDGKDGERGPVGPAGKDGQNGKDGLPGKDGKDGQNGKDGLPGKDGKDGQ 321
                         250
                  ....*....|....*....
gi 1622920110 495 AGPRGDSGQPGPKGDPGRP 513
Cdd:NF038329  322 PGKDGLPGKDGKDGQPGKP 340
VWA pfam00092
von Willebrand factor type A domain;
615-795 4.14e-35

von Willebrand factor type A domain;


Pssm-ID: 459670 [Multi-domain]  Cd Length: 174  Bit Score: 131.63  E-value: 4.14e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 615 DVVFVIDSSESIGYTNFTLEKNFVINVVNRLGAiakdpkSETGTRVGVVQYSHEGTFEaIQLDDERidSLSSFKEAVKNL 694
Cdd:pfam00092   1 DIVFLLDGSGSIGGDNFEKVKEFLKKLVESLDI------GPDGTRVGLVQYSSDVRTE-FPLNDYS--SKEELLSAVDNL 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 695 EWIAGGTW-TPSALKFAYDRLIKESRRQKTRV--FAVVITDGRHDPRDDDLNLRALCDRDVTVTAIGIGDmfhekHESEN 771
Cdd:pfam00092  72 RYLGGGTTnTGKALKYALENLFSSAAGARPGApkVVVLLTDGRSQDGDPEEVARELKSAGVTVFAVGVGN-----ADDEE 146
                         170       180
                  ....*....|....*....|....*...
gi 1622920110 772 LYSIACDKPQQ----VRNMTLFSDLVAE 795
Cdd:pfam00092 147 LRKIASEPGEGhvftVSDFEALEDLQDQ 174
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
305-558 1.98e-34

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 137.34  E-value: 1.98e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 305 FKGEKGEFGADGRKGAPGLAGKNGTDGQKGKLGRIGPPGCKGDPGNRGPDGYPGEAGSPGERGDQGGKgdpgrpgrrgpp 384
Cdd:NF038329  115 GDGEKGEPGPAGPAGPAGEQGPRGDRGETGPAGPAGPPGPQGERGEKGPAGPQGEAGPQGPAGKDGEA------------ 182
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 385 gdiGAKGSKGYQGNNGAPGshgvkgakgGPGPRGPKGEPGRRGDPGTKGSPGSDGPKGEKGDpGPEGPRGLAGEVGNKGA 464
Cdd:NF038329  183 ---GAKGPAGEKGPQGPRG---------ETGPAGEQGPAGPAGPDGEAGPAGEDGPAGPAGD-GQQGPDGDPGPTGEDGP 249
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 465 KGDRGLPGPRGPQGALGEPGNQGSRGDPGDAGPRGDSGQPGPKGDPGRPGFSypGPRGAPGDKGEPGPRGPEGGRGDFGL 544
Cdd:NF038329  250 QGPDGPAGKDGPRGDRGEAGPDGPDGKDGERGPVGPAGKDGQNGKDGLPGKD--GKDGQNGKDGLPGKDGKDGQPGKDGL 327
                         250
                  ....*....|....
gi 1622920110 545 KGEPGRKGEKGEPA 558
Cdd:NF038329  328 PGKDGKDGQPGKPA 341
VWA smart00327
von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins ...
615-801 3.46e-28

von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins mediate adhesion via metal ion-dependent adhesion sites (MIDAS). Intracellular VWA domains and homologues in prokaryotes have recently been identified. The proposed VWA domains in integrin beta subunits have recently been substantiated using sequence-based methods.


Pssm-ID: 214621 [Multi-domain]  Cd Length: 175  Bit Score: 111.78  E-value: 3.46e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110  615 DVVFVIDSSESIGYTNFTLEKNFVINVVNRLgaiakdPKSETGTRVGVVQYSHEgTFEAIQLDDERidSLSSFKEAVKNL 694
Cdd:smart00327   1 DVVFLLDGSGSMGGNRFELAKEFVLKLVEQL------DIGPDGDRVGLVTFSDD-ARVLFPLNDSR--SKDALLEALASL 71
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110  695 EWIAGG-TWTPSALKFAYDRLIKESRRQK--TRVFAVVITDGRHDPRDDDL--NLRALCDRDVTVTAIGIGDMFhekhES 769
Cdd:smart00327  72 SYKLGGgTNLGAALQYALENLFSKSAGSRrgAPKVVILITDGESNDGPKDLlkAAKELKRSGVKVFVVGVGNDV----DE 147
                          170       180       190
                   ....*....|....*....|....*....|..
gi 1622920110  770 ENLYSIACDKPQQVRnmtlFSDLVAEKFIDDM 801
Cdd:smart00327 148 EELKKLASAPGGVYV----FLPELLDLLIDLL 175
VWA pfam00092
von Willebrand factor type A domain;
47-228 1.21e-24

von Willebrand factor type A domain;


Pssm-ID: 459670 [Multi-domain]  Cd Length: 174  Bit Score: 101.58  E-value: 1.21e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110  47 VYFVLDTSESVTMQSptdilLFHMKQFVPQFISQLQNEFYLDQVALswryggLHFSDQVEVFSPPG--SDRASFIKSLQG 124
Cdd:pfam00092   2 IVFLLDGSGSIGGDN-----FEKVKEFLKKLVESLDIGPDGTRVGL------VQYSSDVRTEFPLNdySSKEELLSAVDN 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 125 ISSFRRGT-FTDCALANMTEQI---RQHGTKGTVHFAVVITDGHvtgSPCGGIKLQAERAREEGIRLFAVAPNRNLKEQg 200
Cdd:pfam00092  71 LRYLGGGTtNTGKALKYALENLfssAAGARPGAPKVVVLLTDGR---SQDGDPEEVARELKSAGVTVFAVGVGNADDEE- 146
                         170       180
                  ....*....|....*....|....*...
gi 1622920110 201 LRDIASTPHElyrnDYATMLPDSTEIDQ 228
Cdd:pfam00092 147 LRKIASEPGE----GHVFTVSDFEALED 170
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
255-452 2.84e-24

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 106.91  E-value: 2.84e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 255 PGPPGPKGYRGQKGAKGNMGEPGEPGQKGRQGDPGIEGPIGFPGPKGVPGF-----------------KGEKGEFGADGR 317
Cdd:NF038329  170 AGPQGPAGKDGEAGAKGPAGEKGPQGPRGETGPAGEQGPAGPAGPDGEAGPagedgpagpagdgqqgpDGDPGPTGEDGP 249
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 318 KGAPGLAGKNGTDGQKGKLGRIGPpgckgdPGNRGPDGYPGEAGSPGERGDQGgkgdpgrpgrrgppgDIGAKGSKGYQG 397
Cdd:NF038329  250 QGPDGPAGKDGPRGDRGEAGPDGP------DGKDGERGPVGPAGKDGQNGKDG---------------LPGKDGKDGQNG 308
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1622920110 398 NNGAPGSHGvkgakggpgprgpkgepgRRGDPGTKGSPGSDGPKGEKGDPGPEGP 452
Cdd:NF038329  309 KDGLPGKDG------------------KDGQPGKDGLPGKDGKDGQPGKPAPKTP 345
VWA smart00327
von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins ...
46-212 3.07e-21

von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins mediate adhesion via metal ion-dependent adhesion sites (MIDAS). Intracellular VWA domains and homologues in prokaryotes have recently been identified. The proposed VWA domains in integrin beta subunits have recently been substantiated using sequence-based methods.


Pssm-ID: 214621 [Multi-domain]  Cd Length: 175  Bit Score: 91.75  E-value: 3.07e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110   46 HVYFVLDTSESVTMQSptdilLFHMKQFVPQFISQLQNEFYLDQVALswryggLHFSDQVEVFSPPGS--DRASFIKSLQ 123
Cdd:smart00327   1 DVVFLLDGSGSMGGNR-----FELAKEFVLKLVEQLDIGPDGDRVGL------VTFSDDARVLFPLNDsrSKDALLEALA 69
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110  124 GISSFRRG-TFTDCALANMTEQI---RQHGTKGTVHFAVVITDGHVTGSPcGGIKLQAERAREEGIRLFAVAPNRNLKEQ 199
Cdd:smart00327  70 SLSYKLGGgTNLGAALQYALENLfskSAGSRRGAPKVVILITDGESNDGP-KDLLKAAKELKRSGVKVFVVGVGNDVDEE 148
                          170
                   ....*....|...
gi 1622920110  200 GLRDIASTPHELY 212
Cdd:smart00327 149 ELKKLASAPGGVY 161
YfbK COG2304
Secreted protein containing bacterial Ig-like domain and vWFA domain [General function ...
44-205 8.35e-14

Secreted protein containing bacterial Ig-like domain and vWFA domain [General function prediction only];


Pssm-ID: 441879 [Multi-domain]  Cd Length: 289  Bit Score: 72.83  E-value: 8.35e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110  44 PIHVYFVLDTSESvtMQSPTdilLFHMKQFVPQFISQLQNEfylDQVALswryggLHFSDQVEVFSP--PGSDRASFIKS 121
Cdd:COG2304    91 PLNLVFVIDVSGS--MSGDK---LELAKEAAKLLVDQLRPG---DRVSI------VTFAGDARVLLPptPATDRAKILAA 156
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 122 LQGISSfRRGTFTDCALANMTEQIRQHGTKGTVHFAVVITDGHVTGSPC--GGIKLQAERAREEGIRLFAVAPNRNLKEQ 199
Cdd:COG2304   157 IDRLQA-GGGTALGAGLELAYELARKHFIPGRVNRVILLTDGDANVGITdpEELLKLAEEAREEGITLTTLGVGSDYNED 235

                  ....*.
gi 1622920110 200 GLRDIA 205
Cdd:COG2304   236 LLERLA 241
Collagen pfam01391
Collagen triple helix repeat (20 copies); Members of this family belong to the collagen ...
460-514 1.71e-12

Collagen triple helix repeat (20 copies); Members of this family belong to the collagen superfamily. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The alignment contains 20 copies of the G-X-Y repeat that forms a triple helix. The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxy-proline. Collagens are post translationally modified by proline hydroxylase to form the hydroxy-proline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure. The family includes bacterial collagen-like triple-helix repeat proteins.


Pssm-ID: 460189 [Multi-domain]  Cd Length: 57  Bit Score: 62.90  E-value: 1.71e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1622920110 460 GNKGAKGDRGLPGPRGPQGALGEPGNQGSRGDPGDAGPRGDSGQPGPKGDPGRPG 514
Cdd:pfam01391   1 GPPGPPGPPGPPGPPGPPGPPGPPGPPGPPGEPGPPGPPGPPGPPGPPGAPGAPG 55
ChlD COG1240
vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and ...
613-776 2.42e-12

vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and metabolism];


Pssm-ID: 440853 [Multi-domain]  Cd Length: 262  Bit Score: 68.04  E-value: 2.42e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 613 ALDVVFVIDSSESIGYTN-FTLEKNFVINVVNRLGAiakdpksetGTRVGVVQYSHEgTFEAIQLDderiDSLSSFKEAV 691
Cdd:COG1240    92 GRDVVLVVDASGSMAAENrLEAAKGALLDFLDDYRP---------RDRVGLVAFGGE-AEVLLPLT----RDREALKRAL 157
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 692 KNLEwIAGGTWTPSALKFAYDRLIKESRRQKTRVfaVVITDGRHDPRDDDLN--LRALCDRDVTVTAIGIGDmfhEKHES 769
Cdd:COG1240   158 DELP-PGGGTPLGDALALALELLKRADPARRKVI--VLLTDGRDNAGRIDPLeaAELAAAAGIRIYTIGVGT---EAVDE 231

                  ....*..
gi 1622920110 770 ENLYSIA 776
Cdd:COG1240   232 GLLREIA 238
Collagen pfam01391
Collagen triple helix repeat (20 copies); Members of this family belong to the collagen ...
487-556 1.05e-06

Collagen triple helix repeat (20 copies); Members of this family belong to the collagen superfamily. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The alignment contains 20 copies of the G-X-Y repeat that forms a triple helix. The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxy-proline. Collagens are post translationally modified by proline hydroxylase to form the hydroxy-proline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure. The family includes bacterial collagen-like triple-helix repeat proteins.


Pssm-ID: 460189 [Multi-domain]  Cd Length: 57  Bit Score: 46.33  E-value: 1.05e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 487 GSRGDPGDAGPRGDSGQPGPKGDPGRPGfsYPGPRGAPGdkgepgprgpeggrgdfgLKGEPGRKGEKGE 556
Cdd:pfam01391   1 GPPGPPGPPGPPGPPGPPGPPGPPGPPG--PPGEPGPPG------------------PPGPPGPPGPPGA 50
dermokine cd21118
dermokine; Dermokine, also known as epidermis-specific secreted protein SK30/SK89, is a ...
264-507 3.45e-06

dermokine; Dermokine, also known as epidermis-specific secreted protein SK30/SK89, is a skin-specific glycoprotein that may play a regulatory role in the crosstalk between barrier dysfunction and inflammation, and therefore play a role in inflammatory diseases such as psoriasis. Dermokine is one of the most highly expressed proteins in differentiating keratinocytes, found mainly in the spinous and granular layers of the epidermis, but also in the epithelia of the small intestine, macrophages of the lung, and endothelial cells of the lung. Mouse dermokine has been reported to be encoded by 22 exons, and its expression leads to alpha, beta, and gamma transcripts.


Pssm-ID: 411053 [Multi-domain]  Cd Length: 495  Bit Score: 50.77  E-value: 3.45e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 264 RGQKGAKGNMGEPGEPGQKGRQGDPGIEGPiGFPGPKGVPGFKGekGEFGADGRKGAPGLAGKNGTDGQKGKL-GRIGPP 342
Cdd:cd21118   112 HGVDAVHNSWQGSGGHGAYGSQGGPGVQGH-GIPGGTGGPWASG--GNYGTNSLGGSVGQGGNGGPLNYGTNSqGAVAQP 188
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 343 GCKGDPGNRGPDG--YPGEAGSPGERGDQGGKGDPGRPGRRGPPGDIGAkGSKGYQGNNGAPGSHGvkgakgGPGPRGPK 420
Cdd:cd21118   189 GYGTVRGNNQNSGctNPPPSGSHESFSNSGGSSSSGSSGSQGSHGSNGQ-GSSGSSGGQGNGGNNG------SSSSNSGN 261
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 421 GEPGRRGDPGTKGSPGSDGPKGEKGDPGPegprglAGEVGNKGAKGDRGLPGPRGPQGALGEPGNQGSRGDPGDAGPRGD 500
Cdd:cd21118   262 SGGSNGGSSGNSGSGSGGSSSGGSNGWGG------SSSSGGSGGSGGGNKPECNNPGNDVRMAGGGGSQGSKESSGSHGS 335

                  ....*..
gi 1622920110 501 SGQPGPK 507
Cdd:cd21118   336 NGGNGQA 342
PHA03169 PHA03169
hypothetical protein; Provisional
329-521 1.14e-05

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 48.81  E-value: 1.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 329 TDGQKGKLGRIGppgcKGDPGNRGPDGYPGEAGSPGERGDQGGKgdpgrpgrrgppgdiGAKGSKGYQGNNGAPGSHGVK 408
Cdd:PHA03169   77 EESRHGEKEERG----QGGPSGSGSESVGSPTPSPSGSAEELAS---------------GLSPENTSGSSPESPASHSPP 137
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 409 GAKGGPGPRGPKGEPGRRGDPGTKGSPGSDGPKGEKGDPGPEGPRGLAGEVGNKGAKGDRGLPGPRGPQGAlGEPGNQGs 488
Cdd:PHA03169  138 PSPPSHPGPHEPAPPESHNPSPNQQPSSFLQPSHEDSPEEPEPPTSEPEPDSPGPPQSETPTSSPPPQSPP-DEPGEPQ- 215
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1622920110 489 rGDPGDAGPRGDSGQPGPKGD----PGRPGFSYPGPR 521
Cdd:PHA03169  216 -SPTPQQAPSPNTQQAVEHEDeptePEREGPPFPGHR 251
SPT5 COG5164
Transcription elongation factor SPT5 [Transcription];
427-571 1.34e-05

Transcription elongation factor SPT5 [Transcription];


Pssm-ID: 444063 [Multi-domain]  Cd Length: 495  Bit Score: 48.87  E-value: 1.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 427 GDPGTKGSPGSDGPKGEKGDPGPEGPRGLAGEVGNKGAKGDRGLPGPRGPQGALGEPGNQGSRGDPGDAG---PRGDSGQ 503
Cdd:COG5164    19 TPAGSQGSTKPAQNQGSTRPAGNTGGTRPAQNQGSTTPAGNTGGTRPAGNQGATGPAQNQGGTTPAQNQGgtrPAGNTGG 98
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622920110 504 PGPKGDPGRPGFSYPGPRGAPGDKGEPGPRGPEGGRGDFGLKGE-------PGRKGEKGEPADPGPPGEPGPRGP 571
Cdd:COG5164    99 TTPAGDGGATGPPDDGGATGPPDDGGSTTPPSGGSTTPPGDGGStppgpgsTGPGGSTTPPGDGGSTTPPGPGGS 173
 
Name Accession Description Interval E-value
vWA_collagen_alpha_1-VI-type cd01480
VWA_collagen alpha(VI) type: The extracellular matrix represents a complex alloy of variable ...
612-803 1.75e-68

VWA_collagen alpha(VI) type: The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different collagen types identified thus far. Collagens are centrally involved in the formation of fibrillar and microfibrillar networks of the extracellular matrix, basement membranes as well as other structures of the extracellular matrix. Some collagens have about 15-18 vWA domains in them. The VWA domains present in these collagens mediate protein-protein interactions.


Pssm-ID: 238757 [Multi-domain]  Cd Length: 186  Bit Score: 225.73  E-value: 1.75e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 612 GALDVVFVIDSSESIGYTNFTLEKNFVINVVNRLGAIAKDPKSETGTRVGVVQYSHEGTFEAIQLDDERidSLSSFKEAV 691
Cdd:cd01480     1 GPVDITFVLDSSESVGLQNFDITKNFVKRVAERFLKDYYRKDPAGSWRVGVVQYSDQQEVEAGFLRDIR--NYTSLKEAV 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 692 KNLEWIAGGTWTPSALKFAYDRLIkESRRQKTRVFAVVITDGRHDPRDDDLNLRALCDRDvtvtAIGIGDMFHE--KHES 769
Cdd:cd01480    79 DNLEYIGGGTFTDCALKYATEQLL-EGSHQKENKFLLVITDGHSDGSPDGGIEKAVNEAD----HLGIKIFFVAvgSQNE 153
                         170       180       190
                  ....*....|....*....|....*....|....
gi 1622920110 770 ENLYSIACDKPQQvRNMTLFSDLVAEKFIDDMED 803
Cdd:cd01480   154 EPLSRIACDGKSA-LYRENFAELLWSFFIDDETA 186
vWA_collagen_alpha_1-VI-type cd01480
VWA_collagen alpha(VI) type: The extracellular matrix represents a complex alloy of variable ...
43-231 1.48e-61

VWA_collagen alpha(VI) type: The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different collagen types identified thus far. Collagens are centrally involved in the formation of fibrillar and microfibrillar networks of the extracellular matrix, basement membranes as well as other structures of the extracellular matrix. Some collagens have about 15-18 vWA domains in them. The VWA domains present in these collagens mediate protein-protein interactions.


Pssm-ID: 238757 [Multi-domain]  Cd Length: 186  Bit Score: 206.85  E-value: 1.48e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110  43 CPIHVYFVLDTSESVTMQsPTDILLFHMKQFVPQFISQlqneFYLDQVALSWRYGGLHFSDQVEVFSPPG---SDRASFI 119
Cdd:cd01480     1 GPVDITFVLDSSESVGLQ-NFDITKNFVKRVAERFLKD----YYRKDPAGSWRVGVVQYSDQQEVEAGFLrdiRNYTSLK 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 120 KSLQGISSFRRGTFTDCALANMTEQIRQHGTKGTVHFAVVITDGHVTGSPCGGIKLQAERAREEGIRLFAVAPNRNLKEQ 199
Cdd:cd01480    76 EAVDNLEYIGGGTFTDCALKYATEQLLEGSHQKENKFLLVITDGHSDGSPDGGIEKAVNEADHLGIKIFFVAVGSQNEEP 155
                         170       180       190
                  ....*....|....*....|....*....|...
gi 1622920110 200 gLRDIASTPHE-LYRNDYATMLPDsTEIDQDTI 231
Cdd:cd01480   156 -LSRIACDGKSaLYRENFAELLWS-FFIDDETA 186
vWA_collagen cd01472
von Willebrand factor (vWF) type A domain; equivalent to the I-domain of integrins. This ...
615-789 4.94e-44

von Willebrand factor (vWF) type A domain; equivalent to the I-domain of integrins. This domain has a variety of functions including: intermolecular adhesion, cell migration, signalling, transcription, and DNA repair. In integrins these domains form heterodimers while in vWF it forms homodimers and multimers. There are different interaction surfaces of this domain as seen by its complexes with collagen with either integrin or human vWFA. In integrins collagen binding occurs via the metal ion-dependent adhesion site (MIDAS) and involves three surface loops located on the upper surface of the molecule. In human vWFA, collagen binding is thought to occur on the bottom of the molecule and does not involve the vestigial MIDAS motif.


Pssm-ID: 238749 [Multi-domain]  Cd Length: 164  Bit Score: 156.62  E-value: 4.94e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 615 DVVFVIDSSESIGYTNFTLEKNFVINVVNRLGaiakdpKSETGTRVGVVQYSHEGTFEAiQLDDERidSLSSFKEAVKNL 694
Cdd:cd01472     2 DIVFLVDGSESIGLSNFNLVKDFVKRVVERLD------IGPDGVRVGVVQYSDDPRTEF-YLNTYR--SKDDVLEAVKNL 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 695 EWIAGGTWTPSALKFAYDRLIKES--RRQKTRVFAVVITDGRhdpRDDDLNLRALCDRD--VTVTAIGIGDmfhekHESE 770
Cdd:cd01472    73 RYIGGGTNTGKALKYVRENLFTEAsgSREGVPKVLVVITDGK---SQDDVEEPAVELKQagIEVFAVGVKN-----ADEE 144
                         170       180
                  ....*....|....*....|
gi 1622920110 771 NLYSIACD-KPQQVRNMTLF 789
Cdd:cd01472   145 ELKQIASDpKELYVFNVADF 164
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
255-513 9.70e-43

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 162.00  E-value: 9.70e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 255 PGPPGPKGYRGQKGAKGNMGEPGEPGQKGRQGDPGIEGPIGFPGPKGVPGFKGEKGEfgaDGRKGAPGLAGKNGTDGQKG 334
Cdd:NF038329  122 PGPAGPAGPAGEQGPRGDRGETGPAGPAGPPGPQGERGEKGPAGPQGEAGPQGPAGK---DGEAGAKGPAGEKGPQGPRG 198
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 335 KLGRIGPPGCKGDPGNRGPDGYPGEAGSPGERGDqggkgdpgrpgrrgppgdiGAKGSKGYQGNNGAPGSHGvkgakggp 414
Cdd:NF038329  199 ETGPAGEQGPAGPAGPDGEAGPAGEDGPAGPAGD-------------------GQQGPDGDPGPTGEDGPQG-------- 251
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 415 gprgpkgepgRRGDPGTKGSPGSDGPKGEKGDPGPEGPRGLAGEVGNKGAKGDRGLPGPRGPQGALGEPGNQGSRGDPGD 494
Cdd:NF038329  252 ----------PDGPAGKDGPRGDRGEAGPDGPDGKDGERGPVGPAGKDGQNGKDGLPGKDGKDGQNGKDGLPGKDGKDGQ 321
                         250
                  ....*....|....*....
gi 1622920110 495 AGPRGDSGQPGPKGDPGRP 513
Cdd:NF038329  322 PGKDGLPGKDGKDGQPGKP 340
VWA pfam00092
von Willebrand factor type A domain;
615-795 4.14e-35

von Willebrand factor type A domain;


Pssm-ID: 459670 [Multi-domain]  Cd Length: 174  Bit Score: 131.63  E-value: 4.14e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 615 DVVFVIDSSESIGYTNFTLEKNFVINVVNRLGAiakdpkSETGTRVGVVQYSHEGTFEaIQLDDERidSLSSFKEAVKNL 694
Cdd:pfam00092   1 DIVFLLDGSGSIGGDNFEKVKEFLKKLVESLDI------GPDGTRVGLVQYSSDVRTE-FPLNDYS--SKEELLSAVDNL 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 695 EWIAGGTW-TPSALKFAYDRLIKESRRQKTRV--FAVVITDGRHDPRDDDLNLRALCDRDVTVTAIGIGDmfhekHESEN 771
Cdd:pfam00092  72 RYLGGGTTnTGKALKYALENLFSSAAGARPGApkVVVLLTDGRSQDGDPEEVARELKSAGVTVFAVGVGN-----ADDEE 146
                         170       180
                  ....*....|....*....|....*...
gi 1622920110 772 LYSIACDKPQQ----VRNMTLFSDLVAE 795
Cdd:pfam00092 147 LRKIASEPGEGhvftVSDFEALEDLQDQ 174
vWFA_subfamily_ECM cd01450
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation ...
614-785 5.97e-35

Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains


Pssm-ID: 238727 [Multi-domain]  Cd Length: 161  Bit Score: 130.49  E-value: 5.97e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 614 LDVVFVIDSSESIGYTNFTLEKNFVINVVNRLgaiakdPKSETGTRVGVVQYSHEGTFEaIQLDDEriDSLSSFKEAVKN 693
Cdd:cd01450     1 LDIVFLLDGSESVGPENFEKVKDFIEKLVEKL------DIGPDKTRVGLVQYSDDVRVE-FSLNDY--KSKDDLLKAVKN 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 694 LEWIAG-GTWTPSALKFAYDRLIKES-RRQKTRVFAVVITDGRHDPrDDDLNLRALCDRD--VTVTAIGIGDmfhekHES 769
Cdd:cd01450    72 LKYLGGgGTNTGKALQYALEQLFSESnARENVPKVIIVLTDGRSDD-GGDPKEAAAKLKDegIKVFVVGVGP-----ADE 145
                         170
                  ....*....|....*.
gi 1622920110 770 ENLYSIACDKPQQVRN 785
Cdd:cd01450   146 EELREIASCPSERHVF 161
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
305-558 1.98e-34

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 137.34  E-value: 1.98e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 305 FKGEKGEFGADGRKGAPGLAGKNGTDGQKGKLGRIGPPGCKGDPGNRGPDGYPGEAGSPGERGDQGGKgdpgrpgrrgpp 384
Cdd:NF038329  115 GDGEKGEPGPAGPAGPAGEQGPRGDRGETGPAGPAGPPGPQGERGEKGPAGPQGEAGPQGPAGKDGEA------------ 182
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 385 gdiGAKGSKGYQGNNGAPGshgvkgakgGPGPRGPKGEPGRRGDPGTKGSPGSDGPKGEKGDpGPEGPRGLAGEVGNKGA 464
Cdd:NF038329  183 ---GAKGPAGEKGPQGPRG---------ETGPAGEQGPAGPAGPDGEAGPAGEDGPAGPAGD-GQQGPDGDPGPTGEDGP 249
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 465 KGDRGLPGPRGPQGALGEPGNQGSRGDPGDAGPRGDSGQPGPKGDPGRPGFSypGPRGAPGDKGEPGPRGPEGGRGDFGL 544
Cdd:NF038329  250 QGPDGPAGKDGPRGDRGEAGPDGPDGKDGERGPVGPAGKDGQNGKDGLPGKD--GKDGQNGKDGLPGKDGKDGQPGKDGL 327
                         250
                  ....*....|....
gi 1622920110 545 KGEPGRKGEKGEPA 558
Cdd:NF038329  328 PGKDGKDGQPGKPA 341
vWA_collagen cd01472
von Willebrand factor (vWF) type A domain; equivalent to the I-domain of integrins. This ...
47-219 5.52e-33

von Willebrand factor (vWF) type A domain; equivalent to the I-domain of integrins. This domain has a variety of functions including: intermolecular adhesion, cell migration, signalling, transcription, and DNA repair. In integrins these domains form heterodimers while in vWF it forms homodimers and multimers. There are different interaction surfaces of this domain as seen by its complexes with collagen with either integrin or human vWFA. In integrins collagen binding occurs via the metal ion-dependent adhesion site (MIDAS) and involves three surface loops located on the upper surface of the molecule. In human vWFA, collagen binding is thought to occur on the bottom of the molecule and does not involve the vestigial MIDAS motif.


Pssm-ID: 238749 [Multi-domain]  Cd Length: 164  Bit Score: 125.03  E-value: 5.52e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110  47 VYFVLDTSESVTMQsPTDILLFHMKQFVPQFisqlqnefylDQVALSWRYGGLHFSDQVEVFSPPG--SDRASFIKSLQG 124
Cdd:cd01472     3 IVFLVDGSESIGLS-NFNLVKDFVKRVVERL----------DIGPDGVRVGVVQYSDDPRTEFYLNtyRSKDDVLEAVKN 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 125 ISSFRRGTFTDCALANMTEQIRQHGT---KGTVHFAVVITDGhvtGSPCGGIKLQAErAREEGIRLFAVAPNRNLKEQgL 201
Cdd:cd01472    72 LRYIGGGTNTGKALKYVRENLFTEASgsrEGVPKVLVVITDG---KSQDDVEEPAVE-LKQAGIEVFAVGVKNADEEE-L 146
                         170
                  ....*....|....*...
gi 1622920110 202 RDIASTPHELYRNDYATM 219
Cdd:cd01472   147 KQIASDPKELYVFNVADF 164
VWA smart00327
von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins ...
615-801 3.46e-28

von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins mediate adhesion via metal ion-dependent adhesion sites (MIDAS). Intracellular VWA domains and homologues in prokaryotes have recently been identified. The proposed VWA domains in integrin beta subunits have recently been substantiated using sequence-based methods.


Pssm-ID: 214621 [Multi-domain]  Cd Length: 175  Bit Score: 111.78  E-value: 3.46e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110  615 DVVFVIDSSESIGYTNFTLEKNFVINVVNRLgaiakdPKSETGTRVGVVQYSHEgTFEAIQLDDERidSLSSFKEAVKNL 694
Cdd:smart00327   1 DVVFLLDGSGSMGGNRFELAKEFVLKLVEQL------DIGPDGDRVGLVTFSDD-ARVLFPLNDSR--SKDALLEALASL 71
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110  695 EWIAGG-TWTPSALKFAYDRLIKESRRQK--TRVFAVVITDGRHDPRDDDL--NLRALCDRDVTVTAIGIGDMFhekhES 769
Cdd:smart00327  72 SYKLGGgTNLGAALQYALENLFSKSAGSRrgAPKVVILITDGESNDGPKDLlkAAKELKRSGVKVFVVGVGNDV----DE 147
                          170       180       190
                   ....*....|....*....|....*....|..
gi 1622920110  770 ENLYSIACDKPQQVRnmtlFSDLVAEKFIDDM 801
Cdd:smart00327 148 EELKKLASAPGGVYV----FLPELLDLLIDLL 175
VWA pfam00092
von Willebrand factor type A domain;
47-228 1.21e-24

von Willebrand factor type A domain;


Pssm-ID: 459670 [Multi-domain]  Cd Length: 174  Bit Score: 101.58  E-value: 1.21e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110  47 VYFVLDTSESVTMQSptdilLFHMKQFVPQFISQLQNEFYLDQVALswryggLHFSDQVEVFSPPG--SDRASFIKSLQG 124
Cdd:pfam00092   2 IVFLLDGSGSIGGDN-----FEKVKEFLKKLVESLDIGPDGTRVGL------VQYSSDVRTEFPLNdySSKEELLSAVDN 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 125 ISSFRRGT-FTDCALANMTEQI---RQHGTKGTVHFAVVITDGHvtgSPCGGIKLQAERAREEGIRLFAVAPNRNLKEQg 200
Cdd:pfam00092  71 LRYLGGGTtNTGKALKYALENLfssAAGARPGAPKVVVLLTDGR---SQDGDPEEVARELKSAGVTVFAVGVGNADDEE- 146
                         170       180
                  ....*....|....*....|....*...
gi 1622920110 201 LRDIASTPHElyrnDYATMLPDSTEIDQ 228
Cdd:pfam00092 147 LRKIASEPGE----GHVFTVSDFEALED 170
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
255-452 2.84e-24

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 106.91  E-value: 2.84e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 255 PGPPGPKGYRGQKGAKGNMGEPGEPGQKGRQGDPGIEGPIGFPGPKGVPGF-----------------KGEKGEFGADGR 317
Cdd:NF038329  170 AGPQGPAGKDGEAGAKGPAGEKGPQGPRGETGPAGEQGPAGPAGPDGEAGPagedgpagpagdgqqgpDGDPGPTGEDGP 249
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 318 KGAPGLAGKNGTDGQKGKLGRIGPpgckgdPGNRGPDGYPGEAGSPGERGDQGgkgdpgrpgrrgppgDIGAKGSKGYQG 397
Cdd:NF038329  250 QGPDGPAGKDGPRGDRGEAGPDGP------DGKDGERGPVGPAGKDGQNGKDG---------------LPGKDGKDGQNG 308
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1622920110 398 NNGAPGSHGvkgakggpgprgpkgepgRRGDPGTKGSPGSDGPKGEKGDPGPEGP 452
Cdd:NF038329  309 KDGLPGKDG------------------KDGQPGKDGLPGKDGKDGQPGKPAPKTP 345
vWFA_subfamily_ECM cd01450
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation ...
45-214 7.50e-24

Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains


Pssm-ID: 238727 [Multi-domain]  Cd Length: 161  Bit Score: 98.90  E-value: 7.50e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110  45 IHVYFVLDTSESVTMQSptdillF-HMKQFVPQFISQlqnefyLDQVALSWRYGGLHFSDQVEVFSPPGS--DRASFIKS 121
Cdd:cd01450     1 LDIVFLLDGSESVGPEN------FeKVKDFIEKLVEK------LDIGPDKTRVGLVQYSDDVRVEFSLNDykSKDDLLKA 68
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 122 LQGISSF-RRGTFTDCALANMTEQIRQHGT--KGTVHFAVVITDGHVTGSpcGGIKLQAERAREEGIRLFAVAPNRNLKE 198
Cdd:cd01450    69 VKNLKYLgGGGTNTGKALQYALEQLFSESNarENVPKVIIVLTDGRSDDG--GDPKEAAAKLKDEGIKVFVVGVGPADEE 146
                         170
                  ....*....|....*.
gi 1622920110 199 QgLRDIASTPHELYRN 214
Cdd:cd01450   147 E-LREIASCPSERHVF 161
VWA smart00327
von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins ...
46-212 3.07e-21

von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins mediate adhesion via metal ion-dependent adhesion sites (MIDAS). Intracellular VWA domains and homologues in prokaryotes have recently been identified. The proposed VWA domains in integrin beta subunits have recently been substantiated using sequence-based methods.


Pssm-ID: 214621 [Multi-domain]  Cd Length: 175  Bit Score: 91.75  E-value: 3.07e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110   46 HVYFVLDTSESVTMQSptdilLFHMKQFVPQFISQLQNEFYLDQVALswryggLHFSDQVEVFSPPGS--DRASFIKSLQ 123
Cdd:smart00327   1 DVVFLLDGSGSMGGNR-----FELAKEFVLKLVEQLDIGPDGDRVGL------VTFSDDARVLFPLNDsrSKDALLEALA 69
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110  124 GISSFRRG-TFTDCALANMTEQI---RQHGTKGTVHFAVVITDGHVTGSPcGGIKLQAERAREEGIRLFAVAPNRNLKEQ 199
Cdd:smart00327  70 SLSYKLGGgTNLGAALQYALENLfskSAGSRRGAPKVVILITDGESNDGP-KDLLKAAKELKRSGVKVFVVGVGNDVDEE 148
                          170
                   ....*....|...
gi 1622920110  200 GLRDIASTPHELY 212
Cdd:smart00327 149 ELKKLASAPGGVY 161
vWFA cd00198
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation ...
614-761 1.42e-20

Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains.


Pssm-ID: 238119 [Multi-domain]  Cd Length: 161  Bit Score: 89.55  E-value: 1.42e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 614 LDVVFVIDSSESIGYTNFTLEKNFVINVVNRLgaiakdPKSETGTRVGVVQYSHEGTFEaiqLDDERIDSLSSFKEAVKN 693
Cdd:cd00198     1 ADIVFLLDVSGSMGGEKLDKAKEALKALVSSL------SASPPGDRVGLVTFGSNARVV---LPLTTDTDKADLLEAIDA 71
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622920110 694 LEWIA-GGTWTPSALKFAYdRLIKESRRQKTRVFAVVITDGR--HDPRDDDLNLRALCDRDVTVTAIGIGD 761
Cdd:cd00198    72 LKKGLgGGTNIGAALRLAL-ELLKSAKRPNARRVIILLTDGEpnDGPELLAEAARELRKLGITVYTIGIGD 141
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
612-760 3.44e-19

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 87.44  E-value: 3.44e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 612 GALDVVFVIDSSESIGYTNFTLEKNFVINVVNRLGAiakdpkSETGTRVGVVQYSHegtfeaiQLDDE----RIDSLSSF 687
Cdd:cd01475     1 GPTDLVFLIDSSRSVRPENFELVKQFLNQIIDSLDV------GPDATRVGLVQYSS-------TVKQEfplgRFKSKADL 67
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 688 KEAVKNLEWIAGGTWTPSALKFAYDRLIKES---RRQKTRV--FAVVITDGRhdPRDD--DLNLRALcDRDVTVTAIGIG 760
Cdd:cd01475    68 KRAVRRMEYLETGTMTGLAIQYAMNNAFSEAegaRPGSERVprVGIVVTDGR--PQDDvsEVAAKAR-ALGIEMFAVGVG 144
vWA_integrins_alpha_subunit cd01469
Integrins are a class of adhesion receptors that link the extracellular matrix to the ...
614-793 1.40e-18

Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta sub-unit. Each sub-unit has a large extracellular portion, a single transmembrane segment and a short cytoplasmic domain. The N-terminal domains of the alpha and beta subunits associate to form the integrin headpiece, which contains the ligand binding site, whereas the C-terminal segments traverse the plasma membrane and mediate interaction with the cytoskeleton and with signalling proteins.The VWA domains present in the alpha subunits of integrins seem to be a chordate specific radiation of the gene family being found only in vertebrates. They mediate protein-protein interactions.


Pssm-ID: 238746 [Multi-domain]  Cd Length: 177  Bit Score: 84.33  E-value: 1.40e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 614 LDVVFVIDSSESIGYTNFTLEKNFVINVVNRLgaiAKDPKSetgTRVGVVQYS----HEGTFEAIQldderidSLSSFKE 689
Cdd:cd01469     1 MDIVFVLDGSGSIYPDDFQKVKNFLSTVMKKL---DIGPTK---TQFGLVQYSesfrTEFTLNEYR-------TKEEPLS 67
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 690 AVKNLEWIAGGTWTPSALKFAYDRLIKES---RRQKTRVFaVVITDG-RHDPRDDDLNLRALCDRDVTVTAIGIGDMFHE 765
Cdd:cd01469    68 LVKHISQLLGLTNTATAIQYVVTELFSESngaRKDATKVL-VVITDGeSHDDPLLKDVIPQAEREGIIRYAIGVGGHFQR 146
                         170       180
                  ....*....|....*....|....*....
gi 1622920110 766 KHESENLYSIACDKPQQ-VRNMTLFSDLV 793
Cdd:cd01469   147 ENSREELKTIASKPPEEhFFNVTDFAALK 175
vWA_collagen_alphaI-XII-like cd01482
Collagen: The extracellular matrix represents a complex alloy of variable members of diverse ...
615-780 1.46e-18

Collagen: The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different collagen types identified thus far. Collagens are centrally involved in the formation of fibrillar and microfibrillar networks of the extracellular matrix, basement membranes as well as other structures of the extracellular matrix. Some collagens have about 15-18 vWA domains in them. The VWA domains present in these collagens mediate protein-protein interactions.


Pssm-ID: 238759 [Multi-domain]  Cd Length: 164  Bit Score: 83.88  E-value: 1.46e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 615 DVVFVIDSSESIGYTNFTLEKNFVINVVNRLGAiakdpkSETGTRVGVVQYShegtfeaiqlDDERID-SLSSFK----- 688
Cdd:cd01482     2 DIVFLVDGSWSIGRSNFNLVRSFLSSVVEAFEI------GPDGVQVGLVQYS----------DDPRTEfDLNAYTskedv 65
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 689 -EAVKNLEWIAGGTWTPSALKFAYDRLIKESRRQKTRV--FAVVITDGRhdPRDD-DLNLRALCDRDVTVTAIGIGDmfh 764
Cdd:cd01482    66 lAAIKNLPYKGGNTRTGKALTHVREKNFTPDAGARPGVpkVVILITDGK--SQDDvELPARVLRNLGVNVFAVGVKD--- 140
                         170
                  ....*....|....*.
gi 1622920110 765 ekHESENLYSIAcDKP 780
Cdd:cd01482   141 --ADESELKMIA-SKP 153
vWFA cd00198
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation ...
45-208 3.00e-17

Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains.


Pssm-ID: 238119 [Multi-domain]  Cd Length: 161  Bit Score: 79.92  E-value: 3.00e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110  45 IHVYFVLDTSESVTMQSptdilLFHMKQFVPQFISQLQNEFYLDQVALswryggLHFSDQVEVFSPPG--SDRASFIKSL 122
Cdd:cd00198     1 ADIVFLLDVSGSMGGEK-----LDKAKEALKALVSSLSASPPGDRVGL------VTFGSNARVVLPLTtdTDKADLLEAI 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 123 QGIS-SFRRGTFTDCALANMTEQIRQHGTKGTVHFAVVITDGHVTGSPCGGIKLqAERAREEGIRLFAVAPNRNLKEQGL 201
Cdd:cd00198    70 DALKkGLGGGTNIGAALRLALELLKSAKRPNARRVIILLTDGEPNDGPELLAEA-ARELRKLGITVYTIGIGDDANEDEL 148

                  ....*..
gi 1622920110 202 RDIASTP 208
Cdd:cd00198   149 KEIADKT 155
YfbK COG2304
Secreted protein containing bacterial Ig-like domain and vWFA domain [General function ...
44-205 8.35e-14

Secreted protein containing bacterial Ig-like domain and vWFA domain [General function prediction only];


Pssm-ID: 441879 [Multi-domain]  Cd Length: 289  Bit Score: 72.83  E-value: 8.35e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110  44 PIHVYFVLDTSESvtMQSPTdilLFHMKQFVPQFISQLQNEfylDQVALswryggLHFSDQVEVFSP--PGSDRASFIKS 121
Cdd:COG2304    91 PLNLVFVIDVSGS--MSGDK---LELAKEAAKLLVDQLRPG---DRVSI------VTFAGDARVLLPptPATDRAKILAA 156
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 122 LQGISSfRRGTFTDCALANMTEQIRQHGTKGTVHFAVVITDGHVTGSPC--GGIKLQAERAREEGIRLFAVAPNRNLKEQ 199
Cdd:COG2304   157 IDRLQA-GGGTALGAGLELAYELARKHFIPGRVNRVILLTDGDANVGITdpEELLKLAEEAREEGITLTTLGVGSDYNED 235

                  ....*.
gi 1622920110 200 GLRDIA 205
Cdd:COG2304   236 LLERLA 241
ChlD COG1240
vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and ...
44-205 5.73e-13

vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and metabolism];


Pssm-ID: 440853 [Multi-domain]  Cd Length: 262  Bit Score: 69.97  E-value: 5.73e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110  44 PIHVYFVLDTSESvtMQSPTDILLfhMKQFVPQFISQLQNEfylDQVALswryggLHFSDQVEVFSPPGSDRASFIKSLQ 123
Cdd:COG1240    92 GRDVVLVVDASGS--MAAENRLEA--AKGALLDFLDDYRPR---DRVGL------VAFGGEAEVLLPLTRDREALKRALD 158
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 124 GISSfRRGTFTDCALANMTEQIRQHGTKGTVHfAVVITDGHVTgspCGGIKLQ--AERAREEGIRLFAVA-PNRNLKEQG 200
Cdd:COG1240   159 ELPP-GGGTPLGDALALALELLKRADPARRKV-IVLLTDGRDN---AGRIDPLeaAELAAAAGIRIYTIGvGTEAVDEGL 233

                  ....*
gi 1622920110 201 LRDIA 205
Cdd:COG1240   234 LREIA 238
VWA_integrin_invertebrates cd01476
VWA_integrin (invertebrates): Integrins are a family of cell surface receptors that have ...
614-758 1.00e-12

VWA_integrin (invertebrates): Integrins are a family of cell surface receptors that have diverse functions in cell-cell and cell-extracellular matrix interactions. Because of their involvement in many biologically important adhesion processes, integrins are conserved across a wide range of multicellular animals. Integrins from invertebrates have been identified from six phyla. There are no data to date to suggest any immunological functions for the invertebrate integrins. The members of this sub-group have the conserved MIDAS motif that is charateristic of this domain suggesting the involvement of the integrins in the recognition and binding of multi-ligands.


Pssm-ID: 238753 [Multi-domain]  Cd Length: 163  Bit Score: 67.04  E-value: 1.00e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 614 LDVVFVIDSSESIGYTnFTLEKNFVINVVNRLgaiakdPKSETGTRVGVVQYSHEG-TFEAIQLDDERidSLSSFKEAVK 692
Cdd:cd01476     1 LDLLFVLDSSGSVRGK-FEKYKKYIERIVEGL------EIGPTATRVALITYSGRGrQRVRFNLPKHN--DGEELLEKVD 71
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622920110 693 NLEWIAGGTWTPSALKFAYDRLIK-ESRRQKTRVFAVVITDGR-HD-PRDDDLNLRALCDRDVTVTAIG 758
Cdd:cd01476    72 NLRFIGGTTATGAAIEVALQQLDPsEGRREGIPKVVVVLTDGRsHDdPEKQARILRAVPNIETFAVGTG 140
Collagen pfam01391
Collagen triple helix repeat (20 copies); Members of this family belong to the collagen ...
460-514 1.71e-12

Collagen triple helix repeat (20 copies); Members of this family belong to the collagen superfamily. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The alignment contains 20 copies of the G-X-Y repeat that forms a triple helix. The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxy-proline. Collagens are post translationally modified by proline hydroxylase to form the hydroxy-proline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure. The family includes bacterial collagen-like triple-helix repeat proteins.


Pssm-ID: 460189 [Multi-domain]  Cd Length: 57  Bit Score: 62.90  E-value: 1.71e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1622920110 460 GNKGAKGDRGLPGPRGPQGALGEPGNQGSRGDPGDAGPRGDSGQPGPKGDPGRPG 514
Cdd:pfam01391   1 GPPGPPGPPGPPGPPGPPGPPGPPGPPGPPGEPGPPGPPGPPGPPGPPGAPGAPG 55
ChlD COG1240
vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and ...
613-776 2.42e-12

vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and metabolism];


Pssm-ID: 440853 [Multi-domain]  Cd Length: 262  Bit Score: 68.04  E-value: 2.42e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 613 ALDVVFVIDSSESIGYTN-FTLEKNFVINVVNRLGAiakdpksetGTRVGVVQYSHEgTFEAIQLDderiDSLSSFKEAV 691
Cdd:COG1240    92 GRDVVLVVDASGSMAAENrLEAAKGALLDFLDDYRP---------RDRVGLVAFGGE-AEVLLPLT----RDREALKRAL 157
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 692 KNLEwIAGGTWTPSALKFAYDRLIKESRRQKTRVfaVVITDGRHDPRDDDLN--LRALCDRDVTVTAIGIGDmfhEKHES 769
Cdd:COG1240   158 DELP-PGGGTPLGDALALALELLKRADPARRKVI--VLLTDGRDNAGRIDPLeaAELAAAAGIRIYTIGVGT---EAVDE 231

                  ....*..
gi 1622920110 770 ENLYSIA 776
Cdd:COG1240   232 GLLREIA 238
Collagen pfam01391
Collagen triple helix repeat (20 copies); Members of this family belong to the collagen ...
442-498 2.84e-12

Collagen triple helix repeat (20 copies); Members of this family belong to the collagen superfamily. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The alignment contains 20 copies of the G-X-Y repeat that forms a triple helix. The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxy-proline. Collagens are post translationally modified by proline hydroxylase to form the hydroxy-proline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure. The family includes bacterial collagen-like triple-helix repeat proteins.


Pssm-ID: 460189 [Multi-domain]  Cd Length: 57  Bit Score: 62.13  E-value: 2.84e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622920110 442 GEKGDPGPEGPRGLAGEVGNKGAKGDRGLPGPRGPQGALGEPGNQGSRGDPGDAGPR 498
Cdd:pfam01391   1 GPPGPPGPPGPPGPPGPPGPPGPPGPPGPPGEPGPPGPPGPPGPPGPPGAPGAPGPP 57
Collagen pfam01391
Collagen triple helix repeat (20 copies); Members of this family belong to the collagen ...
463-521 7.69e-12

Collagen triple helix repeat (20 copies); Members of this family belong to the collagen superfamily. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The alignment contains 20 copies of the G-X-Y repeat that forms a triple helix. The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxy-proline. Collagens are post translationally modified by proline hydroxylase to form the hydroxy-proline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure. The family includes bacterial collagen-like triple-helix repeat proteins.


Pssm-ID: 460189 [Multi-domain]  Cd Length: 57  Bit Score: 60.97  E-value: 7.69e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622920110 463 GAKGDRGLPGPRGPQGALGEPGNQGSRGDPGDAGPRGDSGQPGPKGDPGRPGFsyPGPR 521
Cdd:pfam01391   1 GPPGPPGPPGPPGPPGPPGPPGPPGPPGPPGEPGPPGPPGPPGPPGPPGAPGA--PGPP 57
Collagen pfam01391
Collagen triple helix repeat (20 copies); Members of this family belong to the collagen ...
439-495 1.16e-11

Collagen triple helix repeat (20 copies); Members of this family belong to the collagen superfamily. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The alignment contains 20 copies of the G-X-Y repeat that forms a triple helix. The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxy-proline. Collagens are post translationally modified by proline hydroxylase to form the hydroxy-proline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure. The family includes bacterial collagen-like triple-helix repeat proteins.


Pssm-ID: 460189 [Multi-domain]  Cd Length: 57  Bit Score: 60.59  E-value: 1.16e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622920110 439 GPKGEKGDPGPEGPRGLAGEVGNKGAKGDRGLPGPRGPQGALGEPGNQGSRGDPGDA 495
Cdd:pfam01391   1 GPPGPPGPPGPPGPPGPPGPPGPPGPPGPPGEPGPPGPPGPPGPPGPPGAPGAPGPP 57
vWA_micronemal_protein cd01471
Micronemal proteins: The Toxoplasma lytic cycle begins when the parasite actively invades a ...
614-760 1.18e-11

Micronemal proteins: The Toxoplasma lytic cycle begins when the parasite actively invades a target cell. In association with invasion, T. gondii sequentially discharges three sets of secretory organelles beginning with the micronemes, which contain adhesive proteins involved in parasite attachment to a host cell. Deployed as protein complexes, several micronemal proteins possess vertebrate-derived adhesive sequences that function in binding receptors. The VWA domain likely mediates the protein-protein interactions of these with their interacting partners.


Pssm-ID: 238748 [Multi-domain]  Cd Length: 186  Bit Score: 64.33  E-value: 1.18e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 614 LDVVFVIDSSESIGYTN-FTLEKNFVINVVNRLgaiakdPKSETGTRVGVVQYSHEGTfEAIQLDDERI---DSLSSFKE 689
Cdd:cd01471     1 LDLYLLVDGSGSIGYSNwVTHVVPFLHTFVQNL------NISPDEINLYLVTFSTNAK-ELIRLSSPNStnkDLALNAIR 73
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622920110 690 AVKNLEWIAGGTWTPSALKFAyDRLIKESR--RQKTRVFAVVITDGRHDPRDDDLNL-RALCDRDVTVTAIGIG 760
Cdd:cd01471    74 ALLSLYYPNGSTNTTSALLVV-EKHLFDTRgnRENAPQLVIIMTDGIPDSKFRTLKEaRKLRERGVIIAVLGVG 146
Collagen pfam01391
Collagen triple helix repeat (20 copies); Members of this family belong to the collagen ...
433-492 1.23e-11

Collagen triple helix repeat (20 copies); Members of this family belong to the collagen superfamily. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The alignment contains 20 copies of the G-X-Y repeat that forms a triple helix. The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxy-proline. Collagens are post translationally modified by proline hydroxylase to form the hydroxy-proline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure. The family includes bacterial collagen-like triple-helix repeat proteins.


Pssm-ID: 460189 [Multi-domain]  Cd Length: 57  Bit Score: 60.59  E-value: 1.23e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 433 GSPGSDGPKGEKGDPGPEGPRGLAGEvgnKGAKGDRGLPGPRGPQGALGEPGNQGSRGDP 492
Cdd:pfam01391   1 GPPGPPGPPGPPGPPGPPGPPGPPGP---PGPPGEPGPPGPPGPPGPPGPPGAPGAPGPP 57
Collagen pfam01391
Collagen triple helix repeat (20 copies); Members of this family belong to the collagen ...
448-506 1.47e-11

Collagen triple helix repeat (20 copies); Members of this family belong to the collagen superfamily. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The alignment contains 20 copies of the G-X-Y repeat that forms a triple helix. The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxy-proline. Collagens are post translationally modified by proline hydroxylase to form the hydroxy-proline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure. The family includes bacterial collagen-like triple-helix repeat proteins.


Pssm-ID: 460189 [Multi-domain]  Cd Length: 57  Bit Score: 60.20  E-value: 1.47e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622920110 448 GPEGPRGLAGEVGNKGAKGDRGLPGPRGPQgalGEPGNQGSRGDPGDAGPRGDSGQPGP 506
Cdd:pfam01391   1 GPPGPPGPPGPPGPPGPPGPPGPPGPPGPP---GEPGPPGPPGPPGPPGPPGAPGAPGP 56
YfbK COG2304
Secreted protein containing bacterial Ig-like domain and vWFA domain [General function ...
613-765 1.92e-11

Secreted protein containing bacterial Ig-like domain and vWFA domain [General function prediction only];


Pssm-ID: 441879 [Multi-domain]  Cd Length: 289  Bit Score: 65.89  E-value: 1.92e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 613 ALDVVFVIDSSESIGYTNFTLEKNFVINVVNRLGAiakdpksetGTRVGVVQYSHEGTfeaIQLDDERIDSLSSFKEAVK 692
Cdd:COG2304    91 PLNLVFVIDVSGSMSGDKLELAKEAAKLLVDQLRP---------GDRVSIVTFAGDAR---VLLPPTPATDRAKILAAID 158
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622920110 693 NLEwIAGGTWTPSALKFAYDRLIKESRRQKTRVfAVVITDGR--HDPRDDDL---NLRALCDRDVTVTAIGIGDMFHE 765
Cdd:COG2304   159 RLQ-AGGGTALGAGLELAYELARKHFIPGRVNR-VILLTDGDanVGITDPEEllkLAEEAREEGITLTTLGVGSDYNE 234
Collagen pfam01391
Collagen triple helix repeat (20 copies); Members of this family belong to the collagen ...
255-308 5.22e-11

Collagen triple helix repeat (20 copies); Members of this family belong to the collagen superfamily. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The alignment contains 20 copies of the G-X-Y repeat that forms a triple helix. The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxy-proline. Collagens are post translationally modified by proline hydroxylase to form the hydroxy-proline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure. The family includes bacterial collagen-like triple-helix repeat proteins.


Pssm-ID: 460189 [Multi-domain]  Cd Length: 57  Bit Score: 58.66  E-value: 5.22e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1622920110 255 PGPPGPKGYRGQKGAKGNMGEPGEPGQKGRQGDPGIEGPIGFPGPKGVPGFKGE 308
Cdd:pfam01391   3 PGPPGPPGPPGPPGPPGPPGPPGPPGPPGEPGPPGPPGPPGPPGPPGAPGAPGP 56
vWA_collagen_alpha3-VI-like cd01481
VWA_collagen alpha 3(VI) like: The extracellular matrix represents a complex alloy of variable ...
615-789 5.25e-11

VWA_collagen alpha 3(VI) like: The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different collagen types identified thus far. Collagens are centrally involved in the formation of fibrillar and microfibrillar networks of the extracellular matrix, basement membranes as well as other structures of the extracellular matrix. Some collagens have about 15-18 vWA domains in them. The VWA domains present in these collagens mediate protein-protein interactions.


Pssm-ID: 238758  Cd Length: 165  Bit Score: 61.96  E-value: 5.25e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 615 DVVFVIDSSESIGYTNFTLEKNFVINVVNRLGaIAKDPksetgTRVGVVQYSH----EGTFEAIQLDDERIDslssfkeA 690
Cdd:cd01481     2 DIVFLIDGSDNVGSGNFPAIRDFIERIVQSLD-VGPDK-----IRVAVVQFSDtprpEFYLNTHSTKADVLG-------A 68
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 691 VKNLEwIAGGT--WTPSALKFAYDRLIKES--RRQKTRV--FAVVITDGRhdpRDDDLNLRALCDRDVTVTAIGIGDMFH 764
Cdd:cd01481    69 VRRLR-LRGGSqlNTGSALDYVVKNLFTKSagSRIEEGVpqFLVLITGGK---SQDDVERPAVALKRAGIVPFAIGARNA 144
                         170       180
                  ....*....|....*....|....*
gi 1622920110 765 EKHEsenLYSIACDkPQQVRNMTLF 789
Cdd:cd01481   145 DLAE---LQQIAFD-PSFVFQVSDF 165
Collagen pfam01391
Collagen triple helix repeat (20 copies); Members of this family belong to the collagen ...
256-316 1.05e-10

Collagen triple helix repeat (20 copies); Members of this family belong to the collagen superfamily. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The alignment contains 20 copies of the G-X-Y repeat that forms a triple helix. The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxy-proline. Collagens are post translationally modified by proline hydroxylase to form the hydroxy-proline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure. The family includes bacterial collagen-like triple-helix repeat proteins.


Pssm-ID: 460189 [Multi-domain]  Cd Length: 57  Bit Score: 57.89  E-value: 1.05e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622920110 256 GPPGPKGYRGQKGAkgnmgePGEPGQKGRQGDPGIEGPIGFPGPKGVPGFKGEKGEFGADG 316
Cdd:pfam01391   1 GPPGPPGPPGPPGP------PGPPGPPGPPGPPGPPGEPGPPGPPGPPGPPGPPGAPGAPG 55
VWA_2 pfam13519
von Willebrand factor type A domain;
616-728 1.46e-10

von Willebrand factor type A domain;


Pssm-ID: 463909 [Multi-domain]  Cd Length: 103  Bit Score: 58.84  E-value: 1.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 616 VVFVIDSSESI-----GYTNFTLEKNFVINVVNRLGaiakdpksetGTRVGVVQYSHEGTFEaIQLDDERidslSSFKEA 690
Cdd:pfam13519   1 LVFVLDTSGSMrngdyGPTRLEAAKDAVLALLKSLP----------GDRVGLVTFGDGPEVL-IPLTKDR----AKILRA 65
                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1622920110 691 VKNLEWIAGGTWTPSALKFAYDRLIKESRRQKTRVFAV 728
Cdd:pfam13519  66 LRRLEPKGGGTNLAAALQLARAALKHRRKNQPRRIVLI 103
VWA_2 pfam13519
von Willebrand factor type A domain;
47-160 1.85e-09

von Willebrand factor type A domain;


Pssm-ID: 463909 [Multi-domain]  Cd Length: 103  Bit Score: 55.76  E-value: 1.85e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110  47 VYFVLDTSESVTMQSPTDILLFHMKQFVPQFISQLQNefylDQVALswryggLHFSDQVEVFSPPGSDRASFIKSLQGIS 126
Cdd:pfam13519   1 LVFVLDTSGSMRNGDYGPTRLEAAKDAVLALLKSLPG----DRVGL------VTFGDGPEVLIPLTKDRAKILRALRRLE 70
                          90       100       110
                  ....*....|....*....|....*....|....
gi 1622920110 127 SFRRGTFTDCALaNMTEQIRQHGTKGTVHFAVVI 160
Cdd:pfam13519  71 PKGGGTNLAAAL-QLARAALKHRRKNQPRRIVLI 103
Collagen pfam01391
Collagen triple helix repeat (20 copies); Members of this family belong to the collagen ...
271-327 3.90e-09

Collagen triple helix repeat (20 copies); Members of this family belong to the collagen superfamily. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The alignment contains 20 copies of the G-X-Y repeat that forms a triple helix. The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxy-proline. Collagens are post translationally modified by proline hydroxylase to form the hydroxy-proline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure. The family includes bacterial collagen-like triple-helix repeat proteins.


Pssm-ID: 460189 [Multi-domain]  Cd Length: 57  Bit Score: 53.27  E-value: 3.90e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622920110 271 GNMGEPGEPGQKGRQGDPGIEGPIGFPGPKGVPGFKGEKGEFGADGRKGAPGLAGKN 327
Cdd:pfam01391   1 GPPGPPGPPGPPGPPGPPGPPGPPGPPGPPGEPGPPGPPGPPGPPGPPGAPGAPGPP 57
Collagen pfam01391
Collagen triple helix repeat (20 copies); Members of this family belong to the collagen ...
313-367 6.56e-09

Collagen triple helix repeat (20 copies); Members of this family belong to the collagen superfamily. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The alignment contains 20 copies of the G-X-Y repeat that forms a triple helix. The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxy-proline. Collagens are post translationally modified by proline hydroxylase to form the hydroxy-proline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure. The family includes bacterial collagen-like triple-helix repeat proteins.


Pssm-ID: 460189 [Multi-domain]  Cd Length: 57  Bit Score: 52.50  E-value: 6.56e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1622920110 313 GADGRKGAPGLAGKNGTDGQKGKLGRIGPPGCKGDPGNRGPDGYPGEAGSPGERG 367
Cdd:pfam01391   1 GPPGPPGPPGPPGPPGPPGPPGPPGPPGPPGEPGPPGPPGPPGPPGPPGAPGAPG 55
vWA_subgroup cd01465
VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood ...
49-205 7.40e-09

VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains. Not much is known about the function of the VWA domain in these proteins. The members do have a conserved MIDAS motif. The biochemical function however is not known.


Pssm-ID: 238742 [Multi-domain]  Cd Length: 170  Bit Score: 55.74  E-value: 7.40e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110  49 FVLDTSESvtMQSPTdilLFHMKQFVPQFISQLQNEfylDQVALswryggLHFSDQVEVFSPP--GSDRASFIKSLQGIS 126
Cdd:cd01465     5 FVIDRSGS--MDGPK---LPLVKSALKLLVDQLRPD---DRLAI------VTYDGAAETVLPAtpVRDKAAILAAIDRLT 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 127 SfRRGTFTDCALANMTEQIRQHGTKGTVHFAVVITDGHVTGSP--CGGIKLQAERAREEGIRLFAVAPNRNLKEQGLRDI 204
Cdd:cd01465    71 A-GGSTAGGAGIQLGYQEAQKHFVPGGVNRILLATDGDFNVGEtdPDELARLVAQKRESGITLSTLGFGDNYNEDLMEAI 149

                  .
gi 1622920110 205 A 205
Cdd:cd01465   150 A 150
Collagen pfam01391
Collagen triple helix repeat (20 copies); Members of this family belong to the collagen ...
274-342 1.68e-08

Collagen triple helix repeat (20 copies); Members of this family belong to the collagen superfamily. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The alignment contains 20 copies of the G-X-Y repeat that forms a triple helix. The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxy-proline. Collagens are post translationally modified by proline hydroxylase to form the hydroxy-proline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure. The family includes bacterial collagen-like triple-helix repeat proteins.


Pssm-ID: 460189 [Multi-domain]  Cd Length: 57  Bit Score: 51.34  E-value: 1.68e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622920110 274 GEPGEPGQKGRQGDPGIEGPIGFPGPKGVPGFKGekgefgadgrkgAPGLAGKNGTDGQKGKLGRIGPP 342
Cdd:pfam01391   1 GPPGPPGPPGPPGPPGPPGPPGPPGPPGPPGEPG------------PPGPPGPPGPPGPPGAPGAPGPP 57
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
44-219 2.08e-08

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 55.85  E-value: 2.08e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110  44 PIHVYFVLDTSESVtmqSPTDILLfhMKQFVPQFISqlqnefYLDQVALSWRYGGLHFSDQVEVFSPPG--SDRASFIKS 121
Cdd:cd01475     2 PTDLVFLIDSSRSV---RPENFEL--VKQFLNQIID------SLDVGPDATRVGLVQYSSTVKQEFPLGrfKSKADLKRA 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 122 LQGISSFRRGTFTDCALANMTE------QIRQHGTKGTVHFAVVITDGHvtgsPCGGIKLQAERAREEGIRLFAVAPNRN 195
Cdd:cd01475    71 VRRMEYLETGTMTGLAIQYAMNnafseaEGARPGSERVPRVGIVVTDGR----PQDDVSEVAAKARALGIEMFAVGVGRA 146
                         170       180
                  ....*....|....*....|....*..
gi 1622920110 196 LKEQgLRDIASTPHEL---YRNDYATM 219
Cdd:cd01475   147 DEEE-LREIASEPLADhvfYVEDFSTI 172
vWA_subgroup cd01465
VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood ...
614-765 6.13e-08

VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains. Not much is known about the function of the VWA domain in these proteins. The members do have a conserved MIDAS motif. The biochemical function however is not known.


Pssm-ID: 238742 [Multi-domain]  Cd Length: 170  Bit Score: 53.43  E-value: 6.13e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 614 LDVVFVIDSSESIGYTNFTLEKNFVINVVNRLGAiaKDpksetgtRVGVVQYSHEGtfeAIQLDDERIDSLSSFKEAVKN 693
Cdd:cd01465     1 LNLVFVIDRSGSMDGPKLPLVKSALKLLVDQLRP--DD-------RLAIVTYDGAA---ETVLPATPVRDKAAILAAIDR 68
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622920110 694 LEwIAGGTWTPSALKFAYDRLIKESRRQKT-RVFavVITDGR--HDPRDDD---LNLRALCDRDVTVTAIGIGDMFHE 765
Cdd:cd01465    69 LT-AGGSTAGGAGIQLGYQEAQKHFVPGGVnRIL--LATDGDfnVGETDPDelaRLVAQKRESGITLSTLGFGDNYNE 143
vWA_ATR cd01474
ATR (Anthrax Toxin Receptor): Anthrax toxin is a key virulence factor for Bacillus anthracis, ...
47-212 6.45e-08

ATR (Anthrax Toxin Receptor): Anthrax toxin is a key virulence factor for Bacillus anthracis, the causative agent of anthrax. ATR is the cellular receptor for the anthrax protective antigen and facilitates entry of the toxin into cells. The VWA domain in ATR contains the toxin binding site and mediates interaction with protective antigen. The binding is mediated by divalent cations that binds to the MIDAS motif. These proteins are a family of vertebrate ECM receptors expressed by endothelial cells.


Pssm-ID: 238751 [Multi-domain]  Cd Length: 185  Bit Score: 53.67  E-value: 6.45e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110  47 VYFVLDTSESVTMQSPtDILLFhMKQFVPQFIS-QLQNEFyldqvalswryggLHFSDQVEVFSPPGSDRASFIKSLQGI 125
Cdd:cd01474     7 LYFVLDKSGSVAANWI-EIYDF-VEQLVDRFNSpGLRFSF-------------ITFSTRATKILPLTDDSSAIIKGLEVL 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 126 SSFRRG--TFTDCALANMTEQIRQHGTKGTVHFAVVI--TDGHVTGSPCGGIKLQAERAREEGIRLFAVAPNRNLKEQgL 201
Cdd:cd01474    72 KKVTPSgqTYIHEGLENANEQIFNRNGGGRETVSVIIalTDGQLLLNGHKYPEHEAKLSRKLGAIVYCVGVTDFLKSQ-L 150
                         170
                  ....*....|.
gi 1622920110 202 RDIASTPHELY 212
Cdd:cd01474   151 INIADSKEYVF 161
Collagen pfam01391
Collagen triple helix repeat (20 copies); Members of this family belong to the collagen ...
292-363 9.14e-08

Collagen triple helix repeat (20 copies); Members of this family belong to the collagen superfamily. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The alignment contains 20 copies of the G-X-Y repeat that forms a triple helix. The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxy-proline. Collagens are post translationally modified by proline hydroxylase to form the hydroxy-proline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure. The family includes bacterial collagen-like triple-helix repeat proteins.


Pssm-ID: 460189 [Multi-domain]  Cd Length: 57  Bit Score: 49.41  E-value: 9.14e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622920110 292 GPIGFPGPKGVPGFKGEKGEFGADGRKGAPGLAgkngtdgqkgklgriGPPGCKGDPGNRGPDGYPGEAGSP 363
Cdd:pfam01391   1 GPPGPPGPPGPPGPPGPPGPPGPPGPPGPPGEP---------------GPPGPPGPPGPPGPPGAPGAPGPP 57
Collagen pfam01391
Collagen triple helix repeat (20 copies); Members of this family belong to the collagen ...
426-471 6.37e-07

Collagen triple helix repeat (20 copies); Members of this family belong to the collagen superfamily. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The alignment contains 20 copies of the G-X-Y repeat that forms a triple helix. The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxy-proline. Collagens are post translationally modified by proline hydroxylase to form the hydroxy-proline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure. The family includes bacterial collagen-like triple-helix repeat proteins.


Pssm-ID: 460189 [Multi-domain]  Cd Length: 57  Bit Score: 47.10  E-value: 6.37e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1622920110 426 RGDPGTKGSPGSDGPKGEKGDPGPEGPRGLAGEVGNKGAKGDRGLP 471
Cdd:pfam01391  12 PGPPGPPGPPGPPGPPGPPGEPGPPGPPGPPGPPGPPGAPGAPGPP 57
Collagen pfam01391
Collagen triple helix repeat (20 copies); Members of this family belong to the collagen ...
487-556 1.05e-06

Collagen triple helix repeat (20 copies); Members of this family belong to the collagen superfamily. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The alignment contains 20 copies of the G-X-Y repeat that forms a triple helix. The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxy-proline. Collagens are post translationally modified by proline hydroxylase to form the hydroxy-proline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure. The family includes bacterial collagen-like triple-helix repeat proteins.


Pssm-ID: 460189 [Multi-domain]  Cd Length: 57  Bit Score: 46.33  E-value: 1.05e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 487 GSRGDPGDAGPRGDSGQPGPKGDPGRPGfsYPGPRGAPGdkgepgprgpeggrgdfgLKGEPGRKGEKGE 556
Cdd:pfam01391   1 GPPGPPGPPGPPGPPGPPGPPGPPGPPG--PPGEPGPPG------------------PPGPPGPPGPPGA 50
Collagen pfam01391
Collagen triple helix repeat (20 copies); Members of this family belong to the collagen ...
420-468 1.10e-06

Collagen triple helix repeat (20 copies); Members of this family belong to the collagen superfamily. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The alignment contains 20 copies of the G-X-Y repeat that forms a triple helix. The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxy-proline. Collagens are post translationally modified by proline hydroxylase to form the hydroxy-proline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure. The family includes bacterial collagen-like triple-helix repeat proteins.


Pssm-ID: 460189 [Multi-domain]  Cd Length: 57  Bit Score: 46.33  E-value: 1.10e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1622920110 420 KGEPGRRGDPGTKGSPGSDGPKGEKGDPGPEGPRGLAGEVGNKGAKGDR 468
Cdd:pfam01391   9 PGPPGPPGPPGPPGPPGPPGPPGEPGPPGPPGPPGPPGPPGAPGAPGPP 57
vWA_complement_factors cd01470
Complement factors B and C2 are two critical proteases for complement activation. They both ...
614-780 1.65e-06

Complement factors B and C2 are two critical proteases for complement activation. They both contain three CCP or Sushi domains, a trypsin-type serine protease domain and a single VWA domain with a conserved metal ion dependent adhesion site referred commonly as the MIDAS motif. Orthologues of these molecules are found from echinoderms to chordates. During complement activation, the CCP domains are cleaved off, resulting in the formation of an active protease that cleaves and activates complement C3. Complement C2 is in the classical pathway and complement B is in the alternative pathway. The interaction of C2 with C4 and of factor B with C3b are both dependent on Mg2+ binding sites within the VWA domains and the VWA domain of factor B has been shown to mediate the binding of C3. This is consistent with the common inferred function of VWA domains as magnesium-dependent protein interaction domains.


Pssm-ID: 238747 [Multi-domain]  Cd Length: 198  Bit Score: 49.59  E-value: 1.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 614 LDVVFVIDSSESIGYTNFTLEKNFVINVVNRLGAIAKDPksetgtRVGVVQYSHegtfEAIQLDDERIDSLSSFKEAVKN 693
Cdd:cd01470     1 LNIYIALDASDSIGEEDFDEAKNAIKTLIEKISSYEVSP------RYEIISYAS----DPKEIVSIRDFNSNDADDVIKR 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 694 LEWI-------AGGTWTPSALKFAYDRLI-----KESRRQKTRVFAVVITDGRH----DPR------DDDL--NLRALCD 749
Cdd:cd01470    71 LEDFnyddhgdKTGTNTAAALKKVYERMAlekvrNKEAFNETRHVIILFTDGKSnmggSPLptvdkiKNLVykNNKSDNP 150
                         170       180       190
                  ....*....|....*....|....*....|...
gi 1622920110 750 RD--VTVTAIGIGDMFHekheSENLYSIACDKP 780
Cdd:cd01470   151 REdyLDVYVFGVGDDVN----KEELNDLASKKD 179
Collagen pfam01391
Collagen triple helix repeat (20 copies); Members of this family belong to the collagen ...
340-406 2.13e-06

Collagen triple helix repeat (20 copies); Members of this family belong to the collagen superfamily. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The alignment contains 20 copies of the G-X-Y repeat that forms a triple helix. The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxy-proline. Collagens are post translationally modified by proline hydroxylase to form the hydroxy-proline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure. The family includes bacterial collagen-like triple-helix repeat proteins.


Pssm-ID: 460189 [Multi-domain]  Cd Length: 57  Bit Score: 45.56  E-value: 2.13e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622920110 340 GPPGCKGDPGNRGPDGYPGEAGSPGERGDQGGKGDPgrpgrrgppgdiGAKGSKGYQGNNGAPGSHG 406
Cdd:pfam01391   1 GPPGPPGPPGPPGPPGPPGPPGPPGPPGPPGEPGPP------------GPPGPPGPPGPPGAPGAPG 55
dermokine cd21118
dermokine; Dermokine, also known as epidermis-specific secreted protein SK30/SK89, is a ...
264-507 3.45e-06

dermokine; Dermokine, also known as epidermis-specific secreted protein SK30/SK89, is a skin-specific glycoprotein that may play a regulatory role in the crosstalk between barrier dysfunction and inflammation, and therefore play a role in inflammatory diseases such as psoriasis. Dermokine is one of the most highly expressed proteins in differentiating keratinocytes, found mainly in the spinous and granular layers of the epidermis, but also in the epithelia of the small intestine, macrophages of the lung, and endothelial cells of the lung. Mouse dermokine has been reported to be encoded by 22 exons, and its expression leads to alpha, beta, and gamma transcripts.


Pssm-ID: 411053 [Multi-domain]  Cd Length: 495  Bit Score: 50.77  E-value: 3.45e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 264 RGQKGAKGNMGEPGEPGQKGRQGDPGIEGPiGFPGPKGVPGFKGekGEFGADGRKGAPGLAGKNGTDGQKGKL-GRIGPP 342
Cdd:cd21118   112 HGVDAVHNSWQGSGGHGAYGSQGGPGVQGH-GIPGGTGGPWASG--GNYGTNSLGGSVGQGGNGGPLNYGTNSqGAVAQP 188
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 343 GCKGDPGNRGPDG--YPGEAGSPGERGDQGGKGDPGRPGRRGPPGDIGAkGSKGYQGNNGAPGSHGvkgakgGPGPRGPK 420
Cdd:cd21118   189 GYGTVRGNNQNSGctNPPPSGSHESFSNSGGSSSSGSSGSQGSHGSNGQ-GSSGSSGGQGNGGNNG------SSSSNSGN 261
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 421 GEPGRRGDPGTKGSPGSDGPKGEKGDPGPegprglAGEVGNKGAKGDRGLPGPRGPQGALGEPGNQGSRGDPGDAGPRGD 500
Cdd:cd21118   262 SGGSNGGSSGNSGSGSGGSSSGGSNGWGG------SSSSGGSGGSGGGNKPECNNPGNDVRMAGGGGSQGSKESSGSHGS 335

                  ....*..
gi 1622920110 501 SGQPGPK 507
Cdd:cd21118   336 NGGNGQA 342
ViaA COG2425
Uncharacterized conserved protein, contains a von Willebrand factor type A (vWA) domain ...
47-205 4.13e-06

Uncharacterized conserved protein, contains a von Willebrand factor type A (vWA) domain [Function unknown];


Pssm-ID: 441973 [Multi-domain]  Cd Length: 263  Bit Score: 49.29  E-value: 4.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110  47 VYFVLDTSESvtMQ-SPTDILlfhmKQFVPQFISQLQNEfylDQVALswryggLHFSDQVEVFSPPGSDR--ASFIKSLQ 123
Cdd:COG2425   121 VVLCVDTSGS--MAgSKEAAA----KAAALALLRALRPN---RRFGV------ILFDTEVVEDLPLTADDglEDAIEFLS 185
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 124 GisSFRRGTfTDC--ALANMTEQIRQHGTKGTVhfAVVITDGHVTGSPcggIKLQAE-RAREEGIRLFAVA----PNRNL 196
Cdd:COG2425   186 G--LFAGGG-TDIapALRAALELLEEPDYRNAD--IVLITDGEAGVSP---EELLREvRAKESGVRLFTVAigdaGNPGL 257

                  ....*....
gi 1622920110 197 keqgLRDIA 205
Cdd:COG2425   258 ----LEALA 262
PHA03169 PHA03169
hypothetical protein; Provisional
329-521 1.14e-05

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 48.81  E-value: 1.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 329 TDGQKGKLGRIGppgcKGDPGNRGPDGYPGEAGSPGERGDQGGKgdpgrpgrrgppgdiGAKGSKGYQGNNGAPGSHGVK 408
Cdd:PHA03169   77 EESRHGEKEERG----QGGPSGSGSESVGSPTPSPSGSAEELAS---------------GLSPENTSGSSPESPASHSPP 137
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 409 GAKGGPGPRGPKGEPGRRGDPGTKGSPGSDGPKGEKGDPGPEGPRGLAGEVGNKGAKGDRGLPGPRGPQGAlGEPGNQGs 488
Cdd:PHA03169  138 PSPPSHPGPHEPAPPESHNPSPNQQPSSFLQPSHEDSPEEPEPPTSEPEPDSPGPPQSETPTSSPPPQSPP-DEPGEPQ- 215
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1622920110 489 rGDPGDAGPRGDSGQPGPKGD----PGRPGFSYPGPR 521
Cdd:PHA03169  216 -SPTPQQAPSPNTQQAVEHEDeptePEREGPPFPGHR 251
SPT5 COG5164
Transcription elongation factor SPT5 [Transcription];
427-571 1.34e-05

Transcription elongation factor SPT5 [Transcription];


Pssm-ID: 444063 [Multi-domain]  Cd Length: 495  Bit Score: 48.87  E-value: 1.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 427 GDPGTKGSPGSDGPKGEKGDPGPEGPRGLAGEVGNKGAKGDRGLPGPRGPQGALGEPGNQGSRGDPGDAG---PRGDSGQ 503
Cdd:COG5164    19 TPAGSQGSTKPAQNQGSTRPAGNTGGTRPAQNQGSTTPAGNTGGTRPAGNQGATGPAQNQGGTTPAQNQGgtrPAGNTGG 98
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622920110 504 PGPKGDPGRPGFSYPGPRGAPGDKGEPGPRGPEGGRGDFGLKGE-------PGRKGEKGEPADPGPPGEPGPRGP 571
Cdd:COG5164    99 TTPAGDGGATGPPDDGGATGPPDDGGSTTPPSGGSTTPPGDGGStppgpgsTGPGGSTTPPGDGGSTTPPGPGGS 173
PHA03169 PHA03169
hypothetical protein; Provisional
274-514 1.60e-05

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 48.43  E-value: 1.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 274 GEPGEPGQKGRQGDPGIEGPiGFPGPKGVPGFKGEKGEFGADGRKGAPGLAGKNGTDGqkgklgriGPPGCKGDPGNRGP 353
Cdd:PHA03169   70 ESDTETAEESRHGEKEERGQ-GGPSGSGSESVGSPTPSPSGSAEELASGLSPENTSGS--------SPESPASHSPPPSP 140
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 354 DGYPGEaGSPGERGDQGGkgdpgrpgrrgppgdigakgSKGYQGNNGAPGSHgvkgakggpgprgpkGEPGRRGDPGTKG 433
Cdd:PHA03169  141 PSHPGP-HEPAPPESHNP--------------------SPNQQPSSFLQPSH---------------EDSPEEPEPPTSE 184
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 434 SP--GSDGPKGEKGDPGPEGPRGlAGEVGNKGAKGDRGLPGPRGPQGALGEPGNQG-SRGDPGDAGPRGDSGQPGPKGDP 510
Cdd:PHA03169  185 PEpdSPGPPQSETPTSSPPPQSP-PDEPGEPQSPTPQQAPSPNTQQAVEHEDEPTEpEREGPPFPGHRSHSYTVVGWKPS 263

                  ....
gi 1622920110 511 GRPG 514
Cdd:PHA03169  264 TRPG 267
vWA_F09G8-8_type cd01477
VWA F09G8.8 type: Von Willebrand factor type A (vWA) domain was originally found in the blood ...
608-745 2.26e-05

VWA F09G8.8 type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains. The members of this subgroup lack the MIDAS motif. This subgroup is found only in C. elegans and the members identified thus far are always found fused to a C-Lectin type domain. Biochemical function thus far has not be attributed to any of the members of this subgroup.


Pssm-ID: 238754 [Multi-domain]  Cd Length: 193  Bit Score: 46.26  E-value: 2.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 608 EKRCGA------LDVVFVIDSSESIGYTNFTLEKNFVINVVNRLGAIAKDPKSETGTRVGVVQYSHEGTFEAiQLDD-ER 680
Cdd:cd01477     8 DRECGSdiknlwLDIVFVVDNSKGMTQGGLWQVRATISSLFGSSSQIGTDYDDPRSTRVGLVTYNSNATVVA-DLNDlQS 86
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622920110 681 IDSLSSFKEAvkNLEWIAG--GTWTPSALKFAYDRLIKESRRQKTRVFAVVIT-------DGRHDPRDDDLNLR 745
Cdd:cd01477    87 FDDLYSQIQG--SLTDVSStnASYLDTGLQAAEQMLAAGKRTSRENYKKVVIVfasdyndEGSNDPRPIAARLK 158
vWA_BatA_type cd01467
VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood ...
45-212 2.88e-05

VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses. In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains. Members of this subgroup are bacterial in origin. They are typified by the presence of a MIDAS motif.


Pssm-ID: 238744 [Multi-domain]  Cd Length: 180  Bit Score: 45.78  E-value: 2.88e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110  45 IHVYFVLDTSESvtMQSPTDIL---LFHMKQFVPQFISQLQNEfyldqvalswRYGGLHFSDQVEVFSPPGSDRASFIKS 121
Cdd:cd01467     3 RDIMIALDVSGS--MLAQDFVKpsrLEAAKEVLSDFIDRREND----------RIGLVVFAGAAFTQAPLTLDRESLKEL 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 122 LQGISSF--RRGTFTDCALANMTEQIRQHGTKGTVhfAVVITDGHVTGspcGGI-KLQA-ERAREEGIRLFAVA------ 191
Cdd:cd01467    71 LEDIKIGlaGQGTAIGDAIGLAIKRLKNSEAKERV--IVLLTDGENNA---GEIdPATAaELAKNKGVRIYTIGvgksgs 145
                         170       180
                  ....*....|....*....|....*.
gi 1622920110 192 -----PNRNLKEQGLRDIASTPHELY 212
Cdd:cd01467   146 gpkpdGSTILDEDSLVEIADKTGGRI 171
Collagen pfam01391
Collagen triple helix repeat (20 copies); Members of this family belong to the collagen ...
328-370 1.89e-04

Collagen triple helix repeat (20 copies); Members of this family belong to the collagen superfamily. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The alignment contains 20 copies of the G-X-Y repeat that forms a triple helix. The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxy-proline. Collagens are post translationally modified by proline hydroxylase to form the hydroxy-proline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure. The family includes bacterial collagen-like triple-helix repeat proteins.


Pssm-ID: 460189 [Multi-domain]  Cd Length: 57  Bit Score: 40.17  E-value: 1.89e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1622920110 328 GTDGQKGKLGRIGPPGCKGDPGNRGPDGYPGEAGSPGERGDQG 370
Cdd:pfam01391   1 GPPGPPGPPGPPGPPGPPGPPGPPGPPGPPGEPGPPGPPGPPG 43
vWA_integrins_alpha_subunit cd01469
Integrins are a class of adhesion receptors that link the extracellular matrix to the ...
47-210 2.92e-04

Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta sub-unit. Each sub-unit has a large extracellular portion, a single transmembrane segment and a short cytoplasmic domain. The N-terminal domains of the alpha and beta subunits associate to form the integrin headpiece, which contains the ligand binding site, whereas the C-terminal segments traverse the plasma membrane and mediate interaction with the cytoskeleton and with signalling proteins.The VWA domains present in the alpha subunits of integrins seem to be a chordate specific radiation of the gene family being found only in vertebrates. They mediate protein-protein interactions.


Pssm-ID: 238746 [Multi-domain]  Cd Length: 177  Bit Score: 42.73  E-value: 2.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110  47 VYFVLDTSESVtmqSPTDillFH-MKQFVPQFISQLQNEFYLDQVALSwRYGGL---HFSDQVEVFSPPGSDRASFIKSL 122
Cdd:cd01469     3 IVFVLDGSGSI---YPDD---FQkVKNFLSTVMKKLDIGPTKTQFGLV-QYSESfrtEFTLNEYRTKEEPLSLVKHISQL 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 123 QGIssfrrgTFTDCALANMTEQIRQH---GTKGTVHFAVVITDGHVTGSPCGGIKLQAerAREEGIRLFAVAP----NRN 195
Cdd:cd01469    76 LGL------TNTATAIQYVVTELFSEsngARKDATKVLVVITDGESHDDPLLKDVIPQ--AEREGIIRYAIGVgghfQRE 147
                         170
                  ....*....|....*
gi 1622920110 196 LKEQGLRDIASTPHE 210
Cdd:cd01469   148 NSREELKTIASKPPE 162
Collagen pfam01391
Collagen triple helix repeat (20 copies); Members of this family belong to the collagen ...
255-288 3.22e-04

Collagen triple helix repeat (20 copies); Members of this family belong to the collagen superfamily. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The alignment contains 20 copies of the G-X-Y repeat that forms a triple helix. The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxy-proline. Collagens are post translationally modified by proline hydroxylase to form the hydroxy-proline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure. The family includes bacterial collagen-like triple-helix repeat proteins.


Pssm-ID: 460189 [Multi-domain]  Cd Length: 57  Bit Score: 39.40  E-value: 3.22e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1622920110 255 PGPPGPKGYRGQKGAKGNMGEPGEPGQKGRQGDP 288
Cdd:pfam01391  24 PGPPGPPGEPGPPGPPGPPGPPGPPGAPGAPGPP 57
Collagen pfam01391
Collagen triple helix repeat (20 copies); Members of this family belong to the collagen ...
388-459 5.22e-04

Collagen triple helix repeat (20 copies); Members of this family belong to the collagen superfamily. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The alignment contains 20 copies of the G-X-Y repeat that forms a triple helix. The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxy-proline. Collagens are post translationally modified by proline hydroxylase to form the hydroxy-proline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure. The family includes bacterial collagen-like triple-helix repeat proteins.


Pssm-ID: 460189 [Multi-domain]  Cd Length: 57  Bit Score: 39.01  E-value: 5.22e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622920110 388 GAKGSKGYQGNNGAPGSHGvkgakggpgprgPkgepgrRGDPGTKGSPGSDGPKGEKGDPGPEGPRGLAGEV 459
Cdd:pfam01391   4 GPPGPPGPPGPPGPPGPPG------------P------PGPPGPPGEPGPPGPPGPPGPPGPPGAPGAPGPP 57
PHA03169 PHA03169
hypothetical protein; Provisional
427-558 9.74e-04

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 42.65  E-value: 9.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 427 GDPGTKGSPGSDGPKGEKGDPGPEGPRGLAGEVGNKGakgdrglpGPRGPQGALGEPGNQGSRGDPGDAGPRGDSGQPGP 506
Cdd:PHA03169   90 GGPSGSGSESVGSPTPSPSGSAEELASGLSPENTSGS--------SPESPASHSPPPSPPSHPGPHEPAPPESHNPSPNQ 161
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1622920110 507 KGDPGRPGFSYPGPRGAPGDKGEPGPRGPEGGRGDFGLKGEPGRKG--EKGEPA 558
Cdd:PHA03169  162 QPSSFLQPSHEDSPEEPEPPTSEPEPDSPGPPQSETPTSSPPPQSPpdEPGEPQ 215
dermokine cd21118
dermokine; Dermokine, also known as epidermis-specific secreted protein SK30/SK89, is a ...
268-527 1.27e-03

dermokine; Dermokine, also known as epidermis-specific secreted protein SK30/SK89, is a skin-specific glycoprotein that may play a regulatory role in the crosstalk between barrier dysfunction and inflammation, and therefore play a role in inflammatory diseases such as psoriasis. Dermokine is one of the most highly expressed proteins in differentiating keratinocytes, found mainly in the spinous and granular layers of the epidermis, but also in the epithelia of the small intestine, macrophages of the lung, and endothelial cells of the lung. Mouse dermokine has been reported to be encoded by 22 exons, and its expression leads to alpha, beta, and gamma transcripts.


Pssm-ID: 411053 [Multi-domain]  Cd Length: 495  Bit Score: 42.29  E-value: 1.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 268 GAKGNMGEPGEPGQKGRQGDPGIEGpIGFPGPKGVP-GFKGEKGEFGADGRKGAPGL-AGKNGTDGQKGKLGRIGP---P 342
Cdd:cd21118   122 QGSGGHGAYGSQGGPGVQGHGIPGG-TGGPWASGGNyGTNSLGGSVGQGGNGGPLNYgTNSQGAVAQPGYGTVRGNnqnS 200
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 343 GCKGDPGNRGPDGYPGEAGSPGergdqGGKGDPGRPGRRGPPGDIGAKGSKGYQGNNGapgshgvkgakggpgprgpkge 422
Cdd:cd21118   201 GCTNPPPSGSHESFSNSGGSSS-----SGSSGSQGSHGSNGQGSSGSSGGQGNGGNNG---------------------- 253
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 423 pgrrgdpgtkGSPGSDGPKGEkgdpgpegprglagevGNKGAKGDRGlpgprGPQGALGEPGNQGSRGDPGDAGPRGDSG 502
Cdd:cd21118   254 ----------SSSSNSGNSGG----------------SNGGSSGNSG-----SGSGGSSSGGSNGWGGSSSSGGSGGSGG 302
                         250       260
                  ....*....|....*....|....*
gi 1622920110 503 QPGPKGDPGRPGFSYPGPRGAPGDK 527
Cdd:cd21118   303 GNKPECNNPGNDVRMAGGGGSQGSK 327
vWA_Magnesium_chelatase cd01451
Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). ...
699-734 1.81e-03

Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is a three sub-unit (BchI, BchD and BchH) enzyme with a novel arrangement of domains: the C-terminal helical domain is located behind the nucleotide binding site. The BchD domain contains a AAA domain at its N-terminus and a VWA domain at its C-terminus. The VWA domain has been speculated to be involved in mediating protein-protein interactions.


Pssm-ID: 238728 [Multi-domain]  Cd Length: 178  Bit Score: 40.34  E-value: 1.81e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1622920110 699 GGTWTPSALKFAYDRLIKESRRQKTRVFAVVITDGR 734
Cdd:cd01451    74 GGTPLAAGLLAAYELAAEQARDPGQRPLIVVITDGR 109
TerY COG4245
Uncharacterized conserved protein YegL, contains vWA domain of TerY type [Function unknown];
44-207 3.29e-03

Uncharacterized conserved protein YegL, contains vWA domain of TerY type [Function unknown];


Pssm-ID: 443387 [Multi-domain]  Cd Length: 196  Bit Score: 39.91  E-value: 3.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110  44 PIHVYFVLDTSESvtMQ-SPTDILlfhmKQFVPQFISQLQNEFY-LDQVALS--WrygglhFSDQVEVFSPPgSDRASF- 118
Cdd:COG4245     5 RLPVYLLLDTSGS--MSgEPIEAL----NEGLQALIDELRQDPYaLETVEVSviT------FDGEAKVLLPL-TDLEDFq 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 119 IKSLQGissfRRGTFTDCALANMTEQIRQHGTKGTVH-------FAVVITDGHVTGS-PCGGIKLQAERAREEGIRLFAV 190
Cdd:COG4245    72 PPDLSA----SGGTPLGAALELLLDLIERRVQKYTAEgkgdwrpVVFLITDGEPTDSdWEAALQRLKDGEAAKKANIFAI 147
                         170
                  ....*....|....*..
gi 1622920110 191 APNRNLKEQGLRDIAST 207
Cdd:COG4245   148 GVGPDADTEVLKQLTDP 164
vWA_collagen_alphaI-XII-like cd01482
Collagen: The extracellular matrix represents a complex alloy of variable members of diverse ...
76-212 5.91e-03

Collagen: The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different collagen types identified thus far. Collagens are centrally involved in the formation of fibrillar and microfibrillar networks of the extracellular matrix, basement membranes as well as other structures of the extracellular matrix. Some collagens have about 15-18 vWA domains in them. The VWA domains present in these collagens mediate protein-protein interactions.


Pssm-ID: 238759 [Multi-domain]  Cd Length: 164  Bit Score: 38.42  E-value: 5.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110  76 QFISQLQNEFYLDQvalswrYGglhfsdqvevfsppgsDRASFIKSLQGISsFRRG-TFTDCALANMTEQI---RQHGTK 151
Cdd:cd01482    45 QYSDDPRTEFDLNA------YT----------------SKEDVLAAIKNLP-YKGGnTRTGKALTHVREKNftpDAGARP 101
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622920110 152 GTVHFAVVITDGhvtgSPCGGIKLQAERAREEGIRLFAVAPnRNLKEQGLRDIASTPHELY 212
Cdd:cd01482   102 GVPKVVILITDG----KSQDDVELPARVLRNLGVNVFAVGV-KDADESELKMIASKPSETH 157
PHA03169 PHA03169
hypothetical protein; Provisional
256-371 6.98e-03

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 39.95  E-value: 6.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 256 GPPGPKGYRGQKGAKGNmGEPGEPGQKGRQGDPGIEGPigfpgpkgvPGFKGEKGEFGADGRKGAPGLAGKNGTDGQKGK 335
Cdd:PHA03169  127 SPESPASHSPPPSPPSH-PGPHEPAPPESHNPSPNQQP---------SSFLQPSHEDSPEEPEPPTSEPEPDSPGPPQSE 196
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1622920110 336 LGRIGPPGckGDPGNR-GPDGYPGEAGSPGERGDQGG 371
Cdd:PHA03169  197 TPTSSPPP--QSPPDEpGEPQSPTPQQAPSPNTQQAV 231
Collagen pfam01391
Collagen triple helix repeat (20 copies); Members of this family belong to the collagen ...
316-394 7.38e-03

Collagen triple helix repeat (20 copies); Members of this family belong to the collagen superfamily. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The alignment contains 20 copies of the G-X-Y repeat that forms a triple helix. The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxy-proline. Collagens are post translationally modified by proline hydroxylase to form the hydroxy-proline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure. The family includes bacterial collagen-like triple-helix repeat proteins.


Pssm-ID: 460189 [Multi-domain]  Cd Length: 57  Bit Score: 35.55  E-value: 7.38e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622920110 316 GRKGAPGLAGKNGTDGQKGKlgrIGPPGCKGDPGNRGPDGYPGEAGSPGErgdqggkgdpgrpgrRgppgdiGAKGSKG 394
Cdd:pfam01391   1 GPPGPPGPPGPPGPPGPPGP---PGPPGPPGPPGEPGPPGPPGPPGPPGP---------------P------GAPGAPG 55
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
444-525 8.96e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 39.66  E-value: 8.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920110 444 KGDPGPEGPRGLAGEVGNKGAKGDRGLPGPRGPQGALGEPGNQGSRGDPGDAGPRG--------DSGQPGP--KGDPGRP 513
Cdd:PRK14959  373 PSGGGASAPSGSAAEGPASGGAATIPTPGTQGPQGTAPAAGMTPSSAAPATPAPSAapsprvpwDDAPPAPprSGIPPRP 452
                          90
                  ....*....|..
gi 1622920110 514 GFSYPGPRGAPG 525
Cdd:PRK14959  453 APRMPEASPVPG 464
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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