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Conserved domains on  [gi|966930331|ref|XP_014987880|]
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glycerol-3-phosphate dehydrogenase 1-like protein isoform X2 [Macaca mulatta]

Protein Classification

glycerol-3-phosphate dehydrogenase family protein( domain architecture ID 11496765)

glycerol-3-phosphate dehydrogenase family protein is similar to human L-alpha-glycerol-3-phosphate dehydrogenase 1 (GPD1), which catalyzes the reversible biological conversion of dihydroxyacetone (DHAP) to glycerol-3-phosphate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
glycerol3P_DH TIGR03376
glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic ...
 7-344 0e+00

glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic enzyme, glycerol-3-phosphate dehydrogenase (NAD(+)) (EC 1.1.1.8). Enzymatic activity for 1.1.1.8 is defined as sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. Note the very similar reactions of enzymes defined as EC 1.1.1.94 and 1.1.99.5, assigned to families of proteins in the bacteria.


:

Pssm-ID: 274551 [Multi-domain]  Cd Length: 342  Bit Score: 506.49  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966930331    7 KVCIVGSGNWGSAVAKIIGNNVKKL-QKFASTVKMWVFEETVNGRKLTDIINNDHENVKYLPGHKLPENVVAISNLSEAV 85
Cdd:TIGR03376   1 RVAVVGSGNWGTAIAKIVAENARALpELFEESVRMWVFEEEIEGRNLTEIINTTHENVKYLPGIKLPANLVAVPDLVEAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966930331   86 QDADLLVFVIPHQFIHRICDEITGRVPKKALGITLIKGIDEGPEGLKLISDIIREKMGIDISVLMGANIANEVAAEKFCE 165
Cdd:TIGR03376  81 KGADILVFVIPHQFLEGICKQLKGHVKPNARAISCIKGLEVSKDGVKLLSDIIEEELGIPCGVLSGANLANEVAKEKFSE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966930331  166 TTIGSKVMEN----GLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIAFA 241
Cdd:TIGR03376 161 TTVGYRDPADfdvdARVLKALFHRPYFRVNVVDDVAGVEIAGALKNVVAIAAGFVDGLGWGDNAKAAVMRRGLLEMIKFA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966930331  242 RIFCKGQVSTATFlESCGVADLITTCYGGRNRRVAEAFARTGKTIEELEKEMLNGQKLQGPQTSAEVYRILKQKGLVDKF 321
Cdd:TIGR03376 241 RMFFPTGEVTFTF-ESCGVADLITTCLGGRNFKVGRAFAKTGKSLEELEKELLNGQSLQGVATAKEVHELLKNKNKDDEF 319

                         330       340
                  ....*....|....*....|...
gi 966930331  322 PLFTAVYQICYESRPVQEMLCCL 344
Cdd:TIGR03376 320 PLFEAVYQILYEGLPPKKLPECL 342
 
Name Accession Description Interval E-value
glycerol3P_DH TIGR03376
glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic ...
 7-344 0e+00

glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic enzyme, glycerol-3-phosphate dehydrogenase (NAD(+)) (EC 1.1.1.8). Enzymatic activity for 1.1.1.8 is defined as sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. Note the very similar reactions of enzymes defined as EC 1.1.1.94 and 1.1.99.5, assigned to families of proteins in the bacteria.


Pssm-ID: 274551 [Multi-domain]  Cd Length: 342  Bit Score: 506.49  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966930331    7 KVCIVGSGNWGSAVAKIIGNNVKKL-QKFASTVKMWVFEETVNGRKLTDIINNDHENVKYLPGHKLPENVVAISNLSEAV 85
Cdd:TIGR03376   1 RVAVVGSGNWGTAIAKIVAENARALpELFEESVRMWVFEEEIEGRNLTEIINTTHENVKYLPGIKLPANLVAVPDLVEAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966930331   86 QDADLLVFVIPHQFIHRICDEITGRVPKKALGITLIKGIDEGPEGLKLISDIIREKMGIDISVLMGANIANEVAAEKFCE 165
Cdd:TIGR03376  81 KGADILVFVIPHQFLEGICKQLKGHVKPNARAISCIKGLEVSKDGVKLLSDIIEEELGIPCGVLSGANLANEVAKEKFSE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966930331  166 TTIGSKVMEN----GLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIAFA 241
Cdd:TIGR03376 161 TTVGYRDPADfdvdARVLKALFHRPYFRVNVVDDVAGVEIAGALKNVVAIAAGFVDGLGWGDNAKAAVMRRGLLEMIKFA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966930331  242 RIFCKGQVSTATFlESCGVADLITTCYGGRNRRVAEAFARTGKTIEELEKEMLNGQKLQGPQTSAEVYRILKQKGLVDKF 321
Cdd:TIGR03376 241 RMFFPTGEVTFTF-ESCGVADLITTCLGGRNFKVGRAFAKTGKSLEELEKELLNGQSLQGVATAKEVHELLKNKNKDDEF 319

                         330       340
                  ....*....|....*....|...
gi 966930331  322 PLFTAVYQICYESRPVQEMLCCL 344
Cdd:TIGR03376 320 PLFEAVYQILYEGLPPKKLPECL 342
PTZ00345 PTZ00345
glycerol-3-phosphate dehydrogenase; Provisional
 3-341 2.14e-162

glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 240373 [Multi-domain]  Cd Length: 365  Bit Score: 458.33  E-value: 2.14e-162
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966930331   3 AAPLKVCIVGSGNWGSAVAKIIGNNVKKLQKFASTVKMWVFEETVNGRKLTDIINNDHENVKYLPGHKLPENVVAISNLS 82
Cdd:PTZ00345   9 CGPLKVSVIGSGNWGSAISKVVGENTQRNYIFHNEVRMWVLEEIVEGEKLSDIINTKHENVKYLPGIKLPDNIVAVSDLK 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966930331  83 EAVQDADLLVFVIPHQFIHRICDEI--TGRVPKKALGITLIKGIDEGPEGLKLISDIIREKMGIDISVLMGANIANEVAA 160
Cdd:PTZ00345  89 EAVEDADLLIFVIPHQFLESVLSQIkeNNNLKKHARAISLTKGIIVENGKPVLCSDVIEEELGIPCCALSGANVANDVAR 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966930331 161 EKFCETTIGSKVMENGLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIAF 240
Cdd:PTZ00345 169 EEFSEATIGCEDKDDALIWQRLFDRPYFKINCVPDVIGVEVCGALKNIIALAAGFCDGLGLGTNTKSAIIRIGLEEMKLF 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966930331 241 ARIFCKgQVSTATFLESCGVADLITTCYGGRNRRVAEAFARTG--KTIEELEKEMLNGQKLQGPQTSAEVYRILKQKGLV 318
Cdd:PTZ00345 249 GKIFFP-NVMDETFFESCGLADLITTCLGGRNVRCAAEFAKRNgkKSWEEIEAELLNGQKLQGTVTLKEVYEVLESHDLK 327

                        330       340
                 ....*....|....*....|...
gi 966930331 319 DKFPLFTAVYQICYESRPVQEML 341
Cdd:PTZ00345 328 KEFPLFTVTYKIAFEGADPSSLI 350
GpsA COG0240
Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate ...
 7-341 3.19e-91

Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate dehydrogenase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440010 [Multi-domain]  Cd Length: 327  Bit Score: 275.76  E-value: 3.19e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966930331   7 KVCIVGSGNWGSAVAKIIGNNvkklqkfASTVKMWVFEETVngrklTDIINNDHENVKYLPGHKLPENVVAISNLSEAVQ 86
Cdd:COG0240    2 KIAVLGAGSWGTALAKVLARN-------GHEVTLWGRDPEV-----AEEINETRENPRYLPGVKLPENLRATSDLEEALA 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966930331  87 DADLLVFVIPHQFIHRICDEITGRVPKKALGITLIKGIDegPEGLKLISDIIREKMGID--ISVLMGANIANEVAAEKFC 164
Cdd:COG0240   70 GADLVLLAVPSQALREVLEQLAPLLPPGAPVVSATKGIE--PGTGLLMSEVIAEELPGAlrIAVLSGPSFAEEVARGLPT 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966930331 165 ETTIGSKVMENGLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIAFARIF 244
Cdd:COG0240  148 AVVVASEDEEVAERLQELLSTPYFRVYTSDDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLAEMTRLGVAL 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966930331 245 ckgQVSTATFLESCGVADLITTCYG--GRNRRVAEAFARtGKTIEELEKEMlnGQKLQGPQTSAEVYRILKQKGlVDkFP 322
Cdd:COG0240  228 ---GARPETFMGLAGLGDLVLTCTSdlSRNRRFGLALGK-GKSLEEALAEM--GMVAEGVYTAKAVYELAEKLG-VE-MP 299

                        330
                 ....*....|....*....
gi 966930331 323 LFTAVYQICYESRPVQEML 341
Cdd:COG0240  300 ITEAVYAVLYEGKSPREAV 318
NAD_Gly3P_dh_C pfam07479
NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent ...
 195-341 1.07e-62

NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the C-terminal substrate-binding domain.


Pssm-ID: 462178 [Multi-domain]  Cd Length: 142  Bit Score: 196.46  E-value: 1.07e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966930331  195 DADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIAFARIFCKgqvSTATFLESCGVADLITTCYGG--RN 272
Cdd:pfam07479   1 DVIGVELGGALKNVIAIAAGIADGLGLGDNAKAALITRGLAEMIRLGKALGA---KPETFFGLAGLGDLIVTCTSGlsRN 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966930331  273 RRVAEAFARtGKTIEELEKEMlnGQKLQGPQTSAEVYRILKQKGLvdKFPLFTAVYQICYESRPVQEML 341
Cdd:pfam07479  78 RRFGEALGK-GKSLEEAEKEL--GQVAEGVYTAKAVYELAKKLGV--EMPIFEAVYRILYEGKSPEEAL 141
 
Name Accession Description Interval E-value
glycerol3P_DH TIGR03376
glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic ...
 7-344 0e+00

glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic enzyme, glycerol-3-phosphate dehydrogenase (NAD(+)) (EC 1.1.1.8). Enzymatic activity for 1.1.1.8 is defined as sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. Note the very similar reactions of enzymes defined as EC 1.1.1.94 and 1.1.99.5, assigned to families of proteins in the bacteria.


Pssm-ID: 274551 [Multi-domain]  Cd Length: 342  Bit Score: 506.49  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966930331    7 KVCIVGSGNWGSAVAKIIGNNVKKL-QKFASTVKMWVFEETVNGRKLTDIINNDHENVKYLPGHKLPENVVAISNLSEAV 85
Cdd:TIGR03376   1 RVAVVGSGNWGTAIAKIVAENARALpELFEESVRMWVFEEEIEGRNLTEIINTTHENVKYLPGIKLPANLVAVPDLVEAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966930331   86 QDADLLVFVIPHQFIHRICDEITGRVPKKALGITLIKGIDEGPEGLKLISDIIREKMGIDISVLMGANIANEVAAEKFCE 165
Cdd:TIGR03376  81 KGADILVFVIPHQFLEGICKQLKGHVKPNARAISCIKGLEVSKDGVKLLSDIIEEELGIPCGVLSGANLANEVAKEKFSE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966930331  166 TTIGSKVMEN----GLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIAFA 241
Cdd:TIGR03376 161 TTVGYRDPADfdvdARVLKALFHRPYFRVNVVDDVAGVEIAGALKNVVAIAAGFVDGLGWGDNAKAAVMRRGLLEMIKFA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966930331  242 RIFCKGQVSTATFlESCGVADLITTCYGGRNRRVAEAFARTGKTIEELEKEMLNGQKLQGPQTSAEVYRILKQKGLVDKF 321
Cdd:TIGR03376 241 RMFFPTGEVTFTF-ESCGVADLITTCLGGRNFKVGRAFAKTGKSLEELEKELLNGQSLQGVATAKEVHELLKNKNKDDEF 319

                         330       340
                  ....*....|....*....|...
gi 966930331  322 PLFTAVYQICYESRPVQEMLCCL 344
Cdd:TIGR03376 320 PLFEAVYQILYEGLPPKKLPECL 342
PTZ00345 PTZ00345
glycerol-3-phosphate dehydrogenase; Provisional
 3-341 2.14e-162

glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 240373 [Multi-domain]  Cd Length: 365  Bit Score: 458.33  E-value: 2.14e-162
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966930331   3 AAPLKVCIVGSGNWGSAVAKIIGNNVKKLQKFASTVKMWVFEETVNGRKLTDIINNDHENVKYLPGHKLPENVVAISNLS 82
Cdd:PTZ00345   9 CGPLKVSVIGSGNWGSAISKVVGENTQRNYIFHNEVRMWVLEEIVEGEKLSDIINTKHENVKYLPGIKLPDNIVAVSDLK 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966930331  83 EAVQDADLLVFVIPHQFIHRICDEI--TGRVPKKALGITLIKGIDEGPEGLKLISDIIREKMGIDISVLMGANIANEVAA 160
Cdd:PTZ00345  89 EAVEDADLLIFVIPHQFLESVLSQIkeNNNLKKHARAISLTKGIIVENGKPVLCSDVIEEELGIPCCALSGANVANDVAR 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966930331 161 EKFCETTIGSKVMENGLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIAF 240
Cdd:PTZ00345 169 EEFSEATIGCEDKDDALIWQRLFDRPYFKINCVPDVIGVEVCGALKNIIALAAGFCDGLGLGTNTKSAIIRIGLEEMKLF 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966930331 241 ARIFCKgQVSTATFLESCGVADLITTCYGGRNRRVAEAFARTG--KTIEELEKEMLNGQKLQGPQTSAEVYRILKQKGLV 318
Cdd:PTZ00345 249 GKIFFP-NVMDETFFESCGLADLITTCLGGRNVRCAAEFAKRNgkKSWEEIEAELLNGQKLQGTVTLKEVYEVLESHDLK 327

                        330       340
                 ....*....|....*....|...
gi 966930331 319 DKFPLFTAVYQICYESRPVQEML 341
Cdd:PTZ00345 328 KEFPLFTVTYKIAFEGADPSSLI 350
GpsA COG0240
Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate ...
 7-341 3.19e-91

Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate dehydrogenase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440010 [Multi-domain]  Cd Length: 327  Bit Score: 275.76  E-value: 3.19e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966930331   7 KVCIVGSGNWGSAVAKIIGNNvkklqkfASTVKMWVFEETVngrklTDIINNDHENVKYLPGHKLPENVVAISNLSEAVQ 86
Cdd:COG0240    2 KIAVLGAGSWGTALAKVLARN-------GHEVTLWGRDPEV-----AEEINETRENPRYLPGVKLPENLRATSDLEEALA 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966930331  87 DADLLVFVIPHQFIHRICDEITGRVPKKALGITLIKGIDegPEGLKLISDIIREKMGID--ISVLMGANIANEVAAEKFC 164
Cdd:COG0240   70 GADLVLLAVPSQALREVLEQLAPLLPPGAPVVSATKGIE--PGTGLLMSEVIAEELPGAlrIAVLSGPSFAEEVARGLPT 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966930331 165 ETTIGSKVMENGLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIAFARIF 244
Cdd:COG0240  148 AVVVASEDEEVAERLQELLSTPYFRVYTSDDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLAEMTRLGVAL 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966930331 245 ckgQVSTATFLESCGVADLITTCYG--GRNRRVAEAFARtGKTIEELEKEMlnGQKLQGPQTSAEVYRILKQKGlVDkFP 322
Cdd:COG0240  228 ---GARPETFMGLAGLGDLVLTCTSdlSRNRRFGLALGK-GKSLEEALAEM--GMVAEGVYTAKAVYELAEKLG-VE-MP 299

                        330
                 ....*....|....*....
gi 966930331 323 LFTAVYQICYESRPVQEML 341
Cdd:COG0240  300 ITEAVYAVLYEGKSPREAV 318
gpsA PRK00094
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;
7-341 8.87e-80

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;


Pssm-ID: 234629 [Multi-domain]  Cd Length: 325  Bit Score: 246.52  E-value: 8.87e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966930331   7 KVCIVGSGNWGSAVAKIIGNNVKKlqkfastVKMWVFEETVngrklTDIINNDHENVKYLPGHKLPENVVAISNLSEAVQ 86
Cdd:PRK00094   3 KIAVLGAGSWGTALAIVLARNGHD-------VTLWARDPEQ-----AAEINADRENPRYLPGIKLPDNLRATTDLAEALA 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966930331  87 DADLLVFVIPHQFIHRICDEITGRVPKKALGITLIKGIDEGPegLKLISDIIREKMG--IDISVLMGANIANEVAAEKFC 164
Cdd:PRK00094  71 DADLILVAVPSQALREVLKQLKPLLPPDAPIVWATKGIEPGT--GKLLSEVLEEELPdlAPIAVLSGPSFAKEVARGLPT 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966930331 165 ETTIGSKVMENGLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIAFARIF 244
Cdd:PRK00094 149 AVVIASTDEELAERVQELFHSPYFRVYTNTDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLAEITRLGVAL 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966930331 245 -CKgqvsTATFLESCGVADLITTCYG--GRNRRVAEAFARtGKTIEELEKEMlnGQKLQGPQTSAEVYRILKQKGLvdKF 321
Cdd:PRK00094 229 gAN----PETFLGLAGLGDLVLTCTSplSRNRRFGLALGQ-GKSLEEALAEI--GMVAEGVRTAKAVYELAKKLGV--EM 299

                        330       340
                 ....*....|....*....|
gi 966930331 322 PLFTAVYQICYESRPVQEML 341
Cdd:PRK00094 300 PITEAVYAVLYEGKDPREAV 319
NAD_Gly3P_dh_C pfam07479
NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent ...
 195-341 1.07e-62

NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the C-terminal substrate-binding domain.


Pssm-ID: 462178 [Multi-domain]  Cd Length: 142  Bit Score: 196.46  E-value: 1.07e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966930331  195 DADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIAFARIFCKgqvSTATFLESCGVADLITTCYGG--RN 272
Cdd:pfam07479   1 DVIGVELGGALKNVIAIAAGIADGLGLGDNAKAALITRGLAEMIRLGKALGA---KPETFFGLAGLGDLIVTCTSGlsRN 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966930331  273 RRVAEAFARtGKTIEELEKEMlnGQKLQGPQTSAEVYRILKQKGLvdKFPLFTAVYQICYESRPVQEML 341
Cdd:pfam07479  78 RRFGEALGK-GKSLEEAEKEL--GQVAEGVYTAKAVYELAKKLGV--EMPIFEAVYRILYEGKSPEEAL 141
NAD_Gly3P_dh_N pfam01210
NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent ...
 7-175 2.65e-59

NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the N-terminal NAD-binding domain.


Pssm-ID: 395967 [Multi-domain]  Cd Length: 158  Bit Score: 188.17  E-value: 2.65e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966930331    7 KVCIVGSGNWGSAVAKIIGNNvkklqkfASTVKMWVFEEtvngrKLTDIINNDHENVKYLPGHKLPENVVAISNLSEAVQ 86
Cdd:pfam01210   1 KIAVLGAGSWGTALAKVLADN-------GHEVRLWGRDE-----ELIEEINTTHENVRYLPGIKLPENLKATTDLAEALK 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966930331   87 DADLLVFVIPHQFIHRICDEITGRVPKKALGITLIKGIDEGpeGLKLISDIIREKMGI--DISVLMGANIANEVAAEKFC 164
Cdd:pfam01210  69 GADIIVIVVPSQALREVLKQLKGLLKPDAILVSLSKGIEPG--TLKLLSEVIEEELGIqpPIAVLSGPSHAEEVAQGLPT 146

                         170
                  ....*....|.
gi 966930331  165 ETTIGSKVMEN 175
Cdd:pfam01210 147 ATVIASKDEEA 157
PRK12439 PRK12439
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 1-317 7.88e-46

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 171500 [Multi-domain]  Cd Length: 341  Bit Score: 159.56  E-value: 7.88e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966930331   1 MAAA--PLKVCIVGSGNWGSAVAKIIGNNVKKLQkfastvkmWV-FEETVNGrkltdiINNDHENVKYLP-GHKLPENVV 76
Cdd:PRK12439   1 MAAAkrEPKVVVLGGGSWGTTVASICARRGPTLQ--------WVrSAETADD------INDNHRNSRYLGnDVVLSDTLR 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966930331  77 AISNLSEAVQDADLLVFVIP-HQF---IHRICDEITGRVPKkalgITLIKGIDEGPEglKLISDIIREKM-GIDISVLMG 151
Cdd:PRK12439  67 ATTDFAEAANCADVVVMGVPsHGFrgvLTELAKELRPWVPV----VSLVKGLEQGTN--MRMSQIIEEVLpGHPAGILAG 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966930331 152 ANIANEVAAEKFCETTIGSKVMENGLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIR 231
Cdd:PRK12439 141 PNIAREVAEGYAAAAVLAMPDQHLATRLSPLFRTRRFRVYTTDDVVGVEMAGALKNVFAIAVGMGYSLGIGENTRAMVIA 220

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966930331 232 LGLMEMiafARIFCKGQVSTATFLESCGVADLITTCYG--GRNRRVAEAFARtGKTIEELEKEMlnGQKLQGPQTSAEVY 309
Cdd:PRK12439 221 RALREM---TKLGVAMGGNPETFAGLAGMGDLIVTCTSqrSRNRHVGEQLGA-GKPIDEIIASM--NQVAEGVKAASVVM 294


                 ....*...
gi 966930331 310 RILKQKGL 317
Cdd:PRK12439 295 EFADEYGL 302
PRK14618 PRK14618
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 8-333 1.99e-38

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 237770 [Multi-domain]  Cd Length: 328  Bit Score: 139.62  E-value: 1.99e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966930331   8 VCIVGSGNWGSAVAKIignnvkkLQKFASTVKMWVFEETVNGRkltdiINNDHENVKYLPGHKLPENVVAISNLSEAVQD 87
Cdd:PRK14618   7 VAVLGAGAWGTALAVL-------AASKGVPVRLWARRPEFAAA-----LAAERENREYLPGVALPAELYPTADPEEALAG 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966930331  88 ADLLVFVIPHQFIHricdEITGRVPKkALGITL-IKGIDEGPEGLKLISDIIREKMGIDISVLMGANIANEVAAEKFCET 166
Cdd:PRK14618  75 ADFAVVAVPSKALR----ETLAGLPR-ALGYVScAKGLAPDGGRLSELARVLEFLTQARVAVLSGPNHAEEIARFLPAAT 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966930331 167 TIGSKVMENGLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIAFARIFCK 246
Cdd:PRK14618 150 VVASPEPGLARRVQAAFSGPSFRVYTSRDRVGVELGGALKNVIALAAGMVDGLKLGDNAKAALITRGLREMVRFGVALGA 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966930331 247 GQvstATFLESCGVADLITTCYG--GRNRRVAEAFARtgktieelekemlnGQKLQGPQTSAEVYRILKQKGLVDKF--- 321
Cdd:PRK14618 230 EE---ATFYGLSGLGDLIATATSphSRNRAAGEAIVR--------------GVDREHLEAGGKVVEGLYTVKALDAWaka 292

                        330
                 ....*....|....*..
gi 966930331 322 -----PLFTAVYQICYE 333
Cdd:PRK14618 293 hghdlPIVEAVARVARG 309
PRK14620 PRK14620
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 6-339 5.52e-31

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 173083 [Multi-domain]  Cd Length: 326  Bit Score: 119.55  E-value: 5.52e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966930331   6 LKVCIVGSGNWGSAVAKIIGNNvkklqkfASTVKMWvfeetvnGRKLTDI--INNDHENVKYLPGHKLPENVVAISNLSE 83
Cdd:PRK14620   1 MKISILGAGSFGTAIAIALSSK-------KISVNLW-------GRNHTTFesINTKRKNLKYLPTCHLPDNISVKSAIDE 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966930331  84 AVQD-ADLLVFVIPHQFIHRICDEITGRVPKKALGITLI-KGIDEgpEGLKLISDIIREKMGID-ISVLMGANIANEVAA 160
Cdd:PRK14620  67 VLSDnATCIILAVPTQQLRTICQQLQDCHLKKNTPILICsKGIEK--SSLKFPSEIVNEILPNNpIAILSGPSFAKEIAE 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966930331 161 EKFCETTIGSKVMENGLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGlMEMIAF 240
Cdd:PRK14620 145 KLPCSIVLAGQNETLGSSLISKLSNENLKIIYSQDIIGVQIGAALKNIIAIACGIVLGKNLGNNAHAAVITKG-MNEIKT 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966930331 241 ARIFCKGQVSTATFLESCGVADLITTCYGGRNRRVAEAFA-RTGKTIEELEKEmlNGQKLQGPQTSAEVYRILKQkgLVD 319
Cdd:PRK14620 224 LYSAKNGSIDLNTLIGPSCLGDLILTCTTLHSRNMSFGFKiGNGFNINQILSE--GKSVIEGFSTVKPLISLAKK--LNI 299

                        330       340
                 ....*....|....*....|
gi 966930331 320 KFPLFTAVYQICYESRPVQE 339
Cdd:PRK14620 300 ELPICESIYNLLYENISLEK 319
PRK14619 PRK14619
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 5-344 6.97e-27

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 237771 [Multi-domain]  Cd Length: 308  Bit Score: 108.15  E-value: 6.97e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966930331   5 PLKVCIVGSGNWGSAVAKIIGNNvkklqkfASTVKMWvfeetvnGRKLTDiinndhenvkylpghklpenvvaisNLSEA 84
Cdd:PRK14619   4 PKTIAILGAGAWGSTLAGLASAN-------GHRVRVW-------SRRSGL-------------------------SLAAV 44

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966930331  85 VQDADLLVFVIPHQFIHRICDEITG-RVPKKALGITLIKGIDegPEGLKLISDIIREKMGI-DISVLMGANIANEVAAEK 162
Cdd:PRK14619  45 LADADVIVSAVSMKGVRPVAEQVQAlNLPPETIIVTATKGLD--PETTRTPSQIWQAAFPNhPVVVLSGPNLSKEIQQGL 122

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966930331 163 FCETTIGSKVMENGLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIafaR 242
Cdd:PRK14619 123 PAATVVASRDLAAAETVQQIFSSERFRVYTNSDPLGTELGGTLKNVIAIAAGVCDGLQLGTNAKAALVTRALPEMI---R 199

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966930331 243 IFCKGQVSTATFLESCGVADLITTCYG--GRNRRVAEAFARtGKTIEE-LEKemLNGQKlQGPQTSAEVYRILKQKGLVd 319
Cdd:PRK14619 200 VGTHLGAQTETFYGLSGLGDLLATCTSplSRNYQVGYGLAQ-GKSLEQiLAE--LEGTA-EGVNTANVLVQLAQQQNIA- 274

                        330       340
                 ....*....|....*....|....*
gi 966930331 320 kFPLFTAVYQICYESRPVQEMLCCL 344
Cdd:PRK14619 275 -VPITEQVYRLLQGEITPQQALEEL 298
GPD_NAD_C_bact pfam20618
Bacterial GPD, NAD-dependent C-terminal; This is the C-terminal domain of NAD-dependent ...
 258-327 2.81e-07

Bacterial GPD, NAD-dependent C-terminal; This is the C-terminal domain of NAD-dependent glycerol-3-phosphate dehydrogenase (GPD) from bacteria and archaea. GPD catalyzes the reversible reduction of dihydroxyacetone phosphate to glycerol-3-phosphate.


Pssm-ID: 466767 [Multi-domain]  Cd Length: 66  Bit Score: 47.11  E-value: 2.81e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966930331  258 CGVADLITTCYGG--RNRRVAEAFARtGKTIEELEKEMLngqkLQGPQTSAEVYRILKQKGLVDkFPLFTAV 327
Cdd:pfam20618   1 AGLGDLVLTCTSDlsRNRTFGLLLGK-GMTLAEAGNGQV----AEGVRTAKAVAAILARAHNVE-MPILEAV 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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