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Conserved domains on  [gi|966928974|ref|XP_014987243|]
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transmembrane 4 L6 family member 1 isoform X1 [Macaca mulatta]

Protein Classification

transmembrane 4 L6 family member( domain architecture ID 10530709)

transmembrane 4 L6 family member is an L6 domain tetraspanin, similar to TM4SF4 that regulates endocrine pancreas differentiation and directed cell migration

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
L6_membrane pfam05805
L6 membrane protein; This family consists of several eukaryotic L6 membrane proteins. L6, ...
 1-194 2.21e-89

L6 membrane protein; This family consists of several eukaryotic L6 membrane proteins. L6, IL-TMP, and TM4SF5 are cell surface proteins predicted to have four transmembrane domains. Previous sequence analysis led to their assignment as members of the tetraspanin superfamily it has now been found that that they are not significantly related to genuine tetraspanins, but instead constitute their own L6 family. Several members of this family have been implicated in human cancer.


:

Pssm-ID: 461745  Cd Length: 192  Bit Score: 262.50  E-value: 2.21e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928974    1 MCYGKCARCIGHSLVGLALLCIIANILLYFPNGETKYASENHLSRFVWFFSGIVGGGLLMLLPAFVFIGLEQDDCCGCcg 80
Cdd:pfam05805   1 MCTGKCARCLGFSLLPLALLCIIANILLLFPNGEVTYLSEGHISCEVWYFGGIIGGGLLVLLPATVFLLAGRKGGCCS-- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928974   81 henCGKRCAMLSSVLAALIGIAGSGYCVIVAALGLAEGPLCLDSFG--QWNYTFA-STEGQYLLDTSTWSQCTEPKHIVE 157
Cdd:pfam05805  79 ---CGNRCGMFLSILFSAIGVLGAGYCFIVSALALAEGPLCLTNGGstSWGYPFKnNFNGNYLFNQSLWSVCLEPENIVE 155

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 966928974  158 WNVSLFSILLALGGIEFILCLIQVINGVLGGICGFCC 194
Cdd:pfam05805 156 WHVTLFSILLLVSGLELLLCLIQVVNGLLGCLCGTCK 192
 
Name Accession Description Interval E-value
L6_membrane pfam05805
L6 membrane protein; This family consists of several eukaryotic L6 membrane proteins. L6, ...
 1-194 2.21e-89

L6 membrane protein; This family consists of several eukaryotic L6 membrane proteins. L6, IL-TMP, and TM4SF5 are cell surface proteins predicted to have four transmembrane domains. Previous sequence analysis led to their assignment as members of the tetraspanin superfamily it has now been found that that they are not significantly related to genuine tetraspanins, but instead constitute their own L6 family. Several members of this family have been implicated in human cancer.


Pssm-ID: 461745  Cd Length: 192  Bit Score: 262.50  E-value: 2.21e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928974    1 MCYGKCARCIGHSLVGLALLCIIANILLYFPNGETKYASENHLSRFVWFFSGIVGGGLLMLLPAFVFIGLEQDDCCGCcg 80
Cdd:pfam05805   1 MCTGKCARCLGFSLLPLALLCIIANILLLFPNGEVTYLSEGHISCEVWYFGGIIGGGLLVLLPATVFLLAGRKGGCCS-- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928974   81 henCGKRCAMLSSVLAALIGIAGSGYCVIVAALGLAEGPLCLDSFG--QWNYTFA-STEGQYLLDTSTWSQCTEPKHIVE 157
Cdd:pfam05805  79 ---CGNRCGMFLSILFSAIGVLGAGYCFIVSALALAEGPLCLTNGGstSWGYPFKnNFNGNYLFNQSLWSVCLEPENIVE 155

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 966928974  158 WNVSLFSILLALGGIEFILCLIQVINGVLGGICGFCC 194
Cdd:pfam05805 156 WHVTLFSILLLVSGLELLLCLIQVVNGLLGCLCGTCK 192
 
Name Accession Description Interval E-value
L6_membrane pfam05805
L6 membrane protein; This family consists of several eukaryotic L6 membrane proteins. L6, ...
 1-194 2.21e-89

L6 membrane protein; This family consists of several eukaryotic L6 membrane proteins. L6, IL-TMP, and TM4SF5 are cell surface proteins predicted to have four transmembrane domains. Previous sequence analysis led to their assignment as members of the tetraspanin superfamily it has now been found that that they are not significantly related to genuine tetraspanins, but instead constitute their own L6 family. Several members of this family have been implicated in human cancer.


Pssm-ID: 461745  Cd Length: 192  Bit Score: 262.50  E-value: 2.21e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928974    1 MCYGKCARCIGHSLVGLALLCIIANILLYFPNGETKYASENHLSRFVWFFSGIVGGGLLMLLPAFVFIGLEQDDCCGCcg 80
Cdd:pfam05805   1 MCTGKCARCLGFSLLPLALLCIIANILLLFPNGEVTYLSEGHISCEVWYFGGIIGGGLLVLLPATVFLLAGRKGGCCS-- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928974   81 henCGKRCAMLSSVLAALIGIAGSGYCVIVAALGLAEGPLCLDSFG--QWNYTFA-STEGQYLLDTSTWSQCTEPKHIVE 157
Cdd:pfam05805  79 ---CGNRCGMFLSILFSAIGVLGAGYCFIVSALALAEGPLCLTNGGstSWGYPFKnNFNGNYLFNQSLWSVCLEPENIVE 155

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 966928974  158 WNVSLFSILLALGGIEFILCLIQVINGVLGGICGFCC 194
Cdd:pfam05805 156 WHVTLFSILLLVSGLELLLCLIQVVNGLLGCLCGTCK 192
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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