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Conserved domains on  [gi|1622904802|ref|XP_014987134|]
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leucine-rich repeat-containing protein 34 isoform X2 [Macaca mulatta]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1006001)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RNA1 super family cl34950
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 124-428 5.44e-30

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG5238:

Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 121.05  E-value: 5.44e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904802 124 NLLGDVGAYYAAKLVQKQLNLIYLnlMFNDIGPEGGELIAKVLHKNQTLKYLRMTGNKIENKGGMSFAAMLQINSSLEKL 203
Cdd:COG5238   164 RLGLLAAISMAKALQNNSVETVYL--GCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTL 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904802 204 DLGDCDLGMQSVIAFATVLTRNQAIKAINLnrpilYGEQeestvhigrmlkenhclvvlhmckhdIKNSGIQQLCDALYL 283
Cdd:COG5238   242 DLSNNQIGDEGVIALAEALKNNTTVETLYL-----SGNQ--------------------------IGAEGAIALAKALQG 290

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904802 284 NSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGANYLSETLTShNRSLKALSVVSNNIEGEGLVALS 363
Cdd:COG5238   291 NTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQE-NTTLHSLDLSDNQIGDEGAIALA 369

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622904802 364 QSMKTNLTFSHIYIWGNKFDEATCVAYSDLIQMGRLKPDNTDVEPFVVDGRVYLAEVSNGLKKHY 428
Cdd:COG5238   370 KYLEGNTTLRELNLGKNNIGKQGAEALIDALQTNRLHTLILDGNLIGAEAQQRLEQLLERIKSVY 434
 
Name Accession Description Interval E-value
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 124-428 5.44e-30

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 121.05  E-value: 5.44e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904802 124 NLLGDVGAYYAAKLVQKQLNLIYLnlMFNDIGPEGGELIAKVLHKNQTLKYLRMTGNKIENKGGMSFAAMLQINSSLEKL 203
Cdd:COG5238   164 RLGLLAAISMAKALQNNSVETVYL--GCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTL 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904802 204 DLGDCDLGMQSVIAFATVLTRNQAIKAINLnrpilYGEQeestvhigrmlkenhclvvlhmckhdIKNSGIQQLCDALYL 283
Cdd:COG5238   242 DLSNNQIGDEGVIALAEALKNNTTVETLYL-----SGNQ--------------------------IGAEGAIALAKALQG 290

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904802 284 NSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGANYLSETLTShNRSLKALSVVSNNIEGEGLVALS 363
Cdd:COG5238   291 NTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQE-NTTLHSLDLSDNQIGDEGAIALA 369

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622904802 364 QSMKTNLTFSHIYIWGNKFDEATCVAYSDLIQMGRLKPDNTDVEPFVVDGRVYLAEVSNGLKKHY 428
Cdd:COG5238   370 KYLEGNTTLRELNLGKNNIGKQGAEALIDALQTNRLHTLILDGNLIGAEAQQRLEQLLERIKSVY 434
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 119-387 6.86e-26

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 107.06  E-value: 6.86e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904802 119 LDVGYNLLGDVGAYYAAKLVQKQLNLIYLNLMFNDIG--PEGGELIAKVLHKNQTLKYLRMTGNKIENKGGMSFAAMLQi 196
Cdd:cd00116    28 LRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGriPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCGVLESLLR- 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904802 197 NSSLEKLDLGDCDLGMQSVIAFATVLTRNQ-AIKAINLNRPILYGEqeeSTVHIGRMLKENHCLVVLHMCKHDIKNSGIQ 275
Cdd:cd00116   107 SSSLQELKLNNNGLGDRGLRLLAKGLKDLPpALEKLVLGRNRLEGA---SCEALAKALRANRDLKELNLANNGIGDAGIR 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904802 276 QLCDALYLNSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGANYLSETLTSHNRSLKALSVVSNNIE 355
Cdd:cd00116   184 ALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLSPNISLLTLSLSCNDIT 263

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1622904802 356 GEGLVALSQSMKTNLTFSHIYIWGNKFDEATC 387
Cdd:cd00116   264 DDGAKDLAEVLAEKESLLELDLRGNKFGEEGA 295
LRR_8 pfam13855
Leucine rich repeat;
285-354 5.26e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.89  E-value: 5.26e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904802 285 SSLRYLDVSCNKITHDGmvylADVLKSNTTLEVIDLSFNRIenagaNYLSETLTSHNRSLKALSVVSNNI 354
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLD----DGAFKGLSNLKVLDLSNNLL-----TTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
284-311 3.58e-03

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 34.69  E-value: 3.58e-03
                           10        20
                   ....*....|....*....|....*...
gi 1622904802  284 NSSLRYLDVSCNKITHDGMVYLADVLKS 311
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALKD 28
 
Name Accession Description Interval E-value
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 124-428 5.44e-30

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 121.05  E-value: 5.44e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904802 124 NLLGDVGAYYAAKLVQKQLNLIYLnlMFNDIGPEGGELIAKVLHKNQTLKYLRMTGNKIENKGGMSFAAMLQINSSLEKL 203
Cdd:COG5238   164 RLGLLAAISMAKALQNNSVETVYL--GCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTL 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904802 204 DLGDCDLGMQSVIAFATVLTRNQAIKAINLnrpilYGEQeestvhigrmlkenhclvvlhmckhdIKNSGIQQLCDALYL 283
Cdd:COG5238   242 DLSNNQIGDEGVIALAEALKNNTTVETLYL-----SGNQ--------------------------IGAEGAIALAKALQG 290

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904802 284 NSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGANYLSETLTShNRSLKALSVVSNNIEGEGLVALS 363
Cdd:COG5238   291 NTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQE-NTTLHSLDLSDNQIGDEGAIALA 369

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622904802 364 QSMKTNLTFSHIYIWGNKFDEATCVAYSDLIQMGRLKPDNTDVEPFVVDGRVYLAEVSNGLKKHY 428
Cdd:COG5238   370 KYLEGNTTLRELNLGKNNIGKQGAEALIDALQTNRLHTLILDGNLIGAEAQQRLEQLLERIKSVY 434
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 119-369 1.61e-29

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 119.51  E-value: 1.61e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904802 119 LDVGYNLLGDVGAYYAAKLVQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNQTLKYLRMTGNKIENKGGMSFAAMLQINS 198
Cdd:COG5238   185 VYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNT 264

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904802 199 SLEKLDLGDCDLGMQSVIAFATVLTRNQAIKAINLNrpilygeqeestvhigrmlkENHclvvlhmckhdIKNSGIQQLC 278
Cdd:COG5238   265 TVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLS--------------------VNR-----------IGDEGAIALA 313

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904802 279 DALYLNSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGANYLSETLTShNRSLKALSVVSNNIEGEG 358
Cdd:COG5238   314 EGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEG-NTTLRELNLGKNNIGKQG 392

                         250
                  ....*....|.
gi 1622904802 359 LVALSQSMKTN 369
Cdd:COG5238   393 AEALIDALQTN 403
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 116-337 2.54e-27

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 113.35  E-value: 2.54e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904802 116 INGLDVGYNLLGDVGAYYAAKLVQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNQTLKYLRMTGNKIENKGGMSFAAMLQ 195
Cdd:COG5238   210 VTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQ 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904802 196 INSSLEKLDLGDCDLGMQSVIAFATVLTRNQAIKAINLNRPilyGEQEESTVHIGRMLKENHCLVVLHMCKHDIKNSGIQ 275
Cdd:COG5238   290 GNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYN---GIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAI 366

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622904802 276 QLCDALYLNSSLRYLDVSCNKITHDGMVYLADVLKSNtTLEVIDLSFNRIENAGANYLSETL 337
Cdd:COG5238   367 ALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTN-RLHTLILDGNLIGAEAQQRLEQLL 427
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 119-387 6.86e-26

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 107.06  E-value: 6.86e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904802 119 LDVGYNLLGDVGAYYAAKLVQKQLNLIYLNLMFNDIG--PEGGELIAKVLHKNQTLKYLRMTGNKIENKGGMSFAAMLQi 196
Cdd:cd00116    28 LRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGriPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCGVLESLLR- 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904802 197 NSSLEKLDLGDCDLGMQSVIAFATVLTRNQ-AIKAINLNRPILYGEqeeSTVHIGRMLKENHCLVVLHMCKHDIKNSGIQ 275
Cdd:cd00116   107 SSSLQELKLNNNGLGDRGLRLLAKGLKDLPpALEKLVLGRNRLEGA---SCEALAKALRANRDLKELNLANNGIGDAGIR 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904802 276 QLCDALYLNSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGANYLSETLTSHNRSLKALSVVSNNIE 355
Cdd:cd00116   184 ALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLSPNISLLTLSLSCNDIT 263

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1622904802 356 GEGLVALSQSMKTNLTFSHIYIWGNKFDEATC 387
Cdd:cd00116   264 DDGAKDLAEVLAEKESLLELDLRGNKFGEEGA 295
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 124-395 1.54e-25

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 108.34  E-value: 1.54e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904802 124 NLLGDVGAYYAAKLVQKQLNLIYLNLMfndigpeggeliaKVLHKNQTLKYLRMTGNKIENKGGMSFAAMLQINSSLEKL 203
Cdd:COG5238   147 LKDPLGGNAVHLLGLAARLGLLAAISM-------------AKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTL 213

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904802 204 DLGDCDLGMQSVIAFATVLTRNQAIKAINLnrpilygeqeeSTVHIGrmlkenhclvvlhmckhdikNSGIQQLCDALYL 283
Cdd:COG5238   214 WLKRNPIGDEGAEILAEALKGNKSLTTLDL-----------SNNQIG--------------------DEGVIALAEALKN 262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904802 284 NSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGANYLSETLtSHNRSLKALSVVSNNIEGEGLVALS 363
Cdd:COG5238   263 NTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGL-QGNKTLHTLNLAYNGIGAQGAIALA 341

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1622904802 364 QSMKTNLTFSHIYIWGNKFDEATCVAYSDLIQ 395
Cdd:COG5238   342 KALQENTTLHSLDLSDNQIGDEGAIALAKYLE 373
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 110-352 1.01e-21

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 95.50  E-value: 1.01e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904802 110 LKNCLYINGLDVGYNLLGD--VGAYYAAKLVQKQLNLIYLNlmfNDIGPEGGELIAKVLHKNQ-TLKYLRMTGNKIENKG 186
Cdd:cd00116    77 LTKGCGLQELDLSDNALGPdgCGVLESLLRSSSLQELKLNN---NGLGDRGLRLLAKGLKDLPpALEKLVLGRNRLEGAS 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904802 187 GMSFAAMLQINSSLEKLDLGDCDLGMQSVIAFATVLTRNQAIKAINLNrpiLYGEQEESTVHIGRMLKENHCLVVLHMCK 266
Cdd:cd00116   154 CEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLN---NNGLTDEGASALAETLASLKSLEVLNLGD 230

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904802 267 HDIKNSGIQQLCDAL-YLNSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGANYLSETLTSHNRSLK 345
Cdd:cd00116   231 NNLTDAGAAALASALlSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPGNELE 310


                  ....*..
gi 1622904802 346 ALSVVSN 352
Cdd:cd00116   311 SLWVKDD 317
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 165-398 3.46e-20

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 92.55  E-value: 3.46e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904802 165 VLHKNQTLKYLRMTGNKI-ENKGGMSFAAMLQINSSLEKLDLGDCDLGMQSVIAFATVLTRNQAIKAINLNR-PIlygeQ 242
Cdd:COG5238   146 VLKDPLGGNAVHLLGLAArLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRnPI----G 221

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904802 243 EESTVHIGRMLKENHclvvlhmckhdiknsgiqqlcdalylnsSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSF 322
Cdd:COG5238   222 DEGAEILAEALKGNK----------------------------SLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSG 273

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622904802 323 NRIENAGANYLSETLtSHNRSLKALSVVSNNIEGEGLVALSQSMKTNLTFSHIYIWGNKFDEATCVAYSDLIQMGR 398
Cdd:COG5238   274 NQIGAEGAIALAKAL-QGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENT 348
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 76-300 7.31e-19

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 88.31  E-value: 7.31e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904802  76 KGLAAGITLNIAGNNrlvpverVTGEDFWILSRILKNCLYINGLDVGYNLLGDVGAYYAAKLVQKQLNLIYLNLMFNDIG 155
Cdd:COG5238   233 KGNKSLTTLDLSNNQ-------IGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIG 305

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904802 156 PEGGELIAKVLHKNQTLKYLRMTGNKIENKGGMSFAAMLQINSSLEKLDLGDCDLGMQSVIAFATVLTRNQAIKAINLnr 235
Cdd:COG5238   306 DEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNL-- 383

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622904802 236 pilygeqeestvhigrmlkenhclvvlhmCKHDIKNSGIQQLCDALYLNsSLRYLDVSCNKITHD 300
Cdd:COG5238   384 -----------------------------GKNNIGKQGAEALIDALQTN-RLHTLILDGNLIGAE 418
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 210-395 4.31e-16

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 79.83  E-value: 4.31e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904802 210 LGMQSVIAFATVLTRNQAIKAINLNRpiLYGEQEESTVHIGRMLKENHCLVVLHMCKHDIKNSGIQQLCDALYLNSSLRY 289
Cdd:COG5238   135 LALPRRINLIQVLKDPLGGNAVHLLG--LAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTT 212

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904802 290 LDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGANYLSETLTsHNRSLKALSVVSNNIEGEGLVALSQSMKTN 369
Cdd:COG5238   213 LWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALK-NNTTVETLYLSGNQIGAEGAIALAKALQGN 291

                         170       180
                  ....*....|....*....|....*.
gi 1622904802 370 LTFSHIYIWGNKFDEATCVAYSDLIQ 395
Cdd:COG5238   292 TTLTSLDLSVNRIGDEGAIALAEGLQ 317
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 83-252 5.40e-16

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 79.83  E-value: 5.40e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904802  83 TLNIAGNnrlvpveRVTGEDFWILSRILKNCLYINGLDVGYNLLGDVGAYYAAKLVQKQLNLIYLNLMFNDIGPEGGELI 162
Cdd:COG5238   268 TLYLSGN-------QIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIAL 340

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904802 163 AKVLHKNQTLKYLRMTGNKIENKGGMSFAAMLQINSSLEKLDLGDCDLGMQSVIAFATVLTRNQAIKAINLNRPILYGEQ 242
Cdd:COG5238   341 AKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTNRLHTLILDGNLIGAEAQ 420

                         170
                  ....*....|
gi 1622904802 243 EESTVHIGRM 252
Cdd:COG5238   421 QRLEQLLERI 430
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 200-394 8.92e-12

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 65.84  E-value: 8.92e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904802 200 LEKLDLGDCDLGMQSVIAFATVLTRNQAIKAINLnRPILYGEQEESTVHIGRMLKENHCLVVLhmckhDIKNSGIQ---- 275
Cdd:cd00116    25 LQVLRLEGNTLGEEAAKALASALRPQPSLKELCL-SLNETGRIPRGLQSLLQGLTKGCGLQEL-----DLSDNALGpdgc 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904802 276 QLCDALYLNSSLRYLDVSCNKITHDGMVYLADVLKSNT-TLEVIDLSFNRIENAGANYLSETLtSHNRSLKALSVVSNNI 354
Cdd:cd00116    99 GVLESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPpALEKLVLGRNRLEGASCEALAKAL-RANRDLKELNLANNGI 177

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1622904802 355 EGEGLVALSQSMKTNLTFSHIYIWGNKFDEATCVAYSDLI 394
Cdd:cd00116   178 GDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETL 217
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 105-210 1.24e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.88  E-value: 1.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904802 105 ILSRILKNCLYINGLDVGYNLLGDVGAYYAAK-LVQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNQTLKYLRMTGNKIE 183
Cdd:cd00116   212 ALAETLASLKSLEVLNLGDNNLTDAGAAALASaLLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFG 291

                          90       100
                  ....*....|....*....|....*...
gi 1622904802 184 NKG-GMSFAAMLQINSSLEKLDLGDCDL 210
Cdd:cd00116   292 EEGaQLLAESLLEPGNELESLWVKDDSF 319
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
268-355 3.13e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.00  E-value: 3.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904802 268 DIKNSGIQQLCDALYLNSSLRYLDVSCNKIThdgmvYLADVLKSNTTLEVIDLSFNRIENaganyLSETLtSHNRSLKAL 347
Cdd:COG4886   165 DLSNNQLTDLPEELGNLTNLKELDLSNNQIT-----DLPEPLGNLTNLEELDLSGNQLTD-----LPEPL-ANLTNLETL 233


                  ....*...
gi 1622904802 348 SVVSNNIE 355
Cdd:COG4886   234 DLSNNQLT 241
LRR_8 pfam13855
Leucine rich repeat;
285-354 5.26e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.89  E-value: 5.26e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904802 285 SSLRYLDVSCNKITHDGmvylADVLKSNTTLEVIDLSFNRIenagaNYLSETLTSHNRSLKALSVVSNNI 354
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLD----DGAFKGLSNLKVLDLSNNLL-----TTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 258-325 1.89e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.77  E-value: 1.89e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622904802 258 CLVVLhmckhDIKNSGIQQLCDALYLnSSLRYLDVSCNKIthDGMVYLADVLKSNTTLEVIDLSFNRI 325
Cdd:cd21340   121 SLRVL-----NISGNNIDSLEPLAPL-RNLEQLDASNNQI--SDLEELLDLLSSWPSLRELDLTGNPV 180
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
284-311 3.58e-03

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 34.69  E-value: 3.58e-03
                           10        20
                   ....*....|....*....|....*...
gi 1622904802  284 NSSLRYLDVSCNKITHDGMVYLADVLKS 311
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALKD 28
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
143-362 7.06e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 38.76  E-value: 7.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904802 143 NLIYLNLMFNDIgpeggELIAKVLHKNQTLKYLRMTGNKIEnkggmSFAAMLQINSSLEKLDLGDCDLGmqsviAFATVL 222
Cdd:COG4886   114 NLESLDLSGNQL-----TDLPEELANLTNLKELDLSNNQLT-----DLPEPLGNLTNLKSLDLSNNQLT-----DLPEEL 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904802 223 TRNQAIKAINLNR-PIlygeqEESTVHIGRMLKenhcLVVLhmckhDIKNSGIQQLCDALYLNSSLRYLDVSCNKITHdg 301
Cdd:COG4886   179 GNLTNLKELDLSNnQI-----TDLPEPLGNLTN----LEEL-----DLSGNQLTDLPEPLANLTNLETLDLSNNQLTD-- 242

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622904802 302 mvylADVLKSNTTLEVIDLSFNRIENaganyLSETLTSHNrsLKALSVVSNNIEGEGLVAL 362
Cdd:COG4886   243 ----LPELGNLTNLEELDLSNNQLTD-----LPPLANLTN--LKTLDLSNNQLTDLKLKEL 292
LRR_6 pfam13516
Leucine Rich repeat;
168-191 7.11e-03

Leucine Rich repeat;


Pssm-ID: 463907 [Multi-domain]  Cd Length: 24  Bit Score: 33.75  E-value: 7.11e-03
                          10        20
                  ....*....|....*....|....
gi 1622904802 168 KNQTLKYLRMTGNKIENKGGMSFA 191
Cdd:pfam13516   1 SNTHLTTLDLSDNDIGDEGAEALA 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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