NCBI Conserved Domain Search

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...

408-684

9.44e-18

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];

Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 88.46 E-value: 9.44e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 408 LLRLQELQREntflRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKvALQKHSEEVKKQEERVKGRdkhINNLKK 487
Cdd:COG1196  231 LLKLRELEAE----LEELEAELEELEAELEELEAELAELEAELEELRLELE-ELELELEEAQAEEYELLAE---LARLEQ 302

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 488 KCQKESEQNREKQQRIETLERYLADLptLEDHQKQSQQLKDSELKSTELQEKVTELESLLEETQAICRDRETQLESLRQR 567
Cdd:COG1196  303 DIARLEERRRELEERLEELEEELAEL--EEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEE 380

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 568 EAEFSSAGHSLQDKQSVEetsgegpevemeswQKQYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQR 647
Cdd:COG1196  381 LEELAEELLEALRAAAEL--------------AAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEE 446

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 966915597 648 RDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQ 684
Cdd:COG1196  447 AAEEEAELEEEEEALLELLAELLEEAALLEAALAELL 483

SMC_prok_B

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...

419-684

1.96e-13

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]

Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 74.32 E-value: 1.96e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   419 TFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSE---EVKKQEERVKGRDKHINNLKKKCQKESEQ 495
Cdd:TIGR02168  662 TGGSAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEEleeELEQLRKELEELSRQISALRKDLARLEAE 741

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   496 NREKQQRIETLERYLADLptLEDHQKQSQQLKDSELKSTELQEKVTELESLLEETQAICRDRETQLESLRQREAEFSSAG 575
Cdd:TIGR02168  742 VEQLEERIAQLSKELTEL--EAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEA 819

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   576 HSLQDKQSVEETSGEGPEVEMESWQKQYDSLQKIVEK-------QQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRR 648
Cdd:TIGR02168  820 ANLRERLESLERRIAATERRLEDLEEQIEELSEDIESlaaeieeLEELIEELESELEALLNERASLEEALALLRSELEEL 899

                          250       260       270
                   ....*....|....*....|....*....|....*.
gi 966915597   649 DSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQ 684
Cdd:TIGR02168  900 SEELRELESKRSELRRELEELREKLAQLELRLEGLE 935

Cast

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...

293-680

3.69e-11

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.

Pssm-ID: 431111 [Multi-domain] Cd Length: 766 Bit Score: 66.77 E-value: 3.69e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  293 VWQPSPDTWHPREQSCELSTCRQQLEL-IRLQMEQMQLQNGAICHHPAAFAPSLPILEPAQWISILNSNEHLLKEKELL- 370
Cdd:pfam10174  57 VLKEQYRVTQEENQHLQLTIQALQDELrAQRDLNQLLQQDFTTSPVDGEDKFSTPELTEENFRRLQSEHERQAKELFLLr 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  371 ---------IDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLR---------------LQELQRENTFLR---- 422
Cdd:pfam10174 137 ktleemelrIETQKQTLGARDESIKKLLEMLQSKGLPKKSGEEDWERTRriaeaemqlghlevlLDQKEKENIHLReelh 216

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  423 -----AQFAQKTEALSR------EKI-DLEKKLSASEVEVQLIRESLKVALQKHSEEVkKQEERVKGRDKHINN----LK 486
Cdd:pfam10174 217 rrnqlQPDPAKTKALQTviemkdTKIsSLERNIRDLEDEVQMLKTNGLLHTEDREEEI-KQMEVYKSHSKFMKNkidqLK 295

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  487 KKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSqqLKDSELKSTELQEKVTELESLLEETQAICRDRETQLESLRQ 566
Cdd:pfam10174 296 QELSKKESELLALQTKLETLTNQNSDCKQHIEVLKES--LTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTE 373

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  567 REAEFSSAGHSLQDKQSVEETsgegpevEMESWQKQYDSLQKIVEKQQQKMDQLRSQVQSLEQE--------------VA 632
Cdd:pfam10174 374 EKSTLAGEIRDLKDMLDVKER-------KINVLQKKIENLQEQLRDKDKQLAGLKERVKSLQTDssntdtalttleeaLS 446

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 966915597  633 QEEGTSQALREEAQRRDsalQQLRTAVKELSVQNQDLIEKNLTLQEHL 680
Cdd:pfam10174 447 EKERIIERLKEQRERED---RERLEELESLKKENKDLKEKVSALQPEL 491

PRK03918

DNA double-strand break repair ATPase Rad50;

361-682

3.67e-10

DNA double-strand break repair ATPase Rad50;

Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 63.54 E-value: 3.67e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 361 EHLLKEKELLIDKQRKHISQLEQKVRESElqvhsallgrpapfgdvcllRLQELQRENTFLRAQFAQKTEALSRekidLE 440
Cdd:PRK03918 258 EEKIRELEERIEELKKEIEELEEKVKELK--------------------ELKEKAEEYIKLSEFYEEYLDELRE----IE 313

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 441 KKLSASEVEVQLIRESLKvALQKHSEEVKKQEERVKGRDKHINNLKKKcQKESEQNREKQQRIETLERYLADLPTledhQ 520
Cdd:PRK03918 314 KRLSRLEEEINGIEERIK-ELEEKEERLEELKKKLKELEKRLEELEER-HELYEEAKAKKEELERLKKRLTGLTP----E 387

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 521 KQSQQLKDSELKSTELQEKVTELESLLEETQAICRDRETQLESLRQREAEFSSAGHSLQdkqsvEETSGEgpevEMESWQ 600
Cdd:PRK03918 388 KLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAKGKCPVCGRELT-----EEHRKE----LLEEYT 458

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 601 KQYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEegtsqalrEEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHL 680
Cdd:PRK03918 459 AELKRIEKELKEIEEKERKLRKELRELEKVLKKE--------SELIKLKELAEQLKELEEKLKKYNLEELEKKAEEYEKL 530


                 ..
gi 966915597 681 RQ 682
Cdd:PRK03918 531 KE 532

EnvC

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...

593-779

1.34e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];

Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 48.22 E-value: 1.34e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 593 EVEMESWQKQYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVKELsvqNQDLIEK 672
Cdd:COG4942   26 EAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAEL---RAELEAQ 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 673 NLTLQEHLRQAQPGSPPSPDTAQLALELYQELASCLQDLQAVcsivtqraqghdpnlslllgihsqhpeTQLDLQKPDVI 752
Cdd:COG4942  103 KEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYL---------------------------APARREQAEEL 155

                        170       180
                 ....*....|....*....|....*..
gi 966915597 753 KRKLEEVQQLRRDIEDLRTTMSDRYAQ 779
Cdd:COG4942  156 RADLAELAALRAELEAERAELEALLAE 182

V_Alix_like

cd08915

Protein-interacting V-domain of mammalian Alix and related domains; This superfamily contains ...

376-679

1.25e-04

Protein-interacting V-domain of mammalian Alix and related domains; This superfamily contains the V-shaped (V) domain of mammalian Alix (apoptosis-linked gene-2 interacting protein X), His-Domain type N23 protein tyrosine phosphatase (HD-PTP, also known as PTPN23), Bro1 and Rim20 (also known as PalA) from Saccharomyces cerevisiae, and related domains. Alix, HD-PTP, Bro1, and Rim20 all interact with the ESCRT (Endosomal Sorting Complexes Required for Transport) system. Alix, also known as apoptosis-linked gene-2 interacting protein 1 (AIP1), participates in membrane remodeling processes during the budding of enveloped viruses, vesicle budding inside late endosomal multivesicular bodies (MVBs), and the abscission reactions of mammalian cell division. It also functions in apoptosis. HD-PTP functions in cell migration and endosomal trafficking, Bro1 in endosomal trafficking, and Rim20 in the response to the external pH via the Rim101 pathway. The Alix V-domain contains a binding site, partially conserved in this superfamily, for the retroviral late assembly (L) domain YPXnL motif. The Alix V-domain is also a dimerization domain. Members of this superfamily have an N-terminal Bro1-like domain, which binds components of the ESCRT-III complex. The Bro1-like domains of Alix and HD-PTP can also bind human immunodeficiency virus type 1 (HIV-1) nucleocapsid. Many members, including Alix, HD-PTP, and Bro1, also have a proline-rich region (PRR), which binds multiple partners in Alix, including Tsg101 (tumor susceptibility gene 101, a component of ESCRT-1) and the apoptotic protein ALG-2. The C-terminal portion (V-domain and PRR) of Bro1 interacts with Doa4, a ubiquitin thiolesterase needed to remove ubiquitin from MVB cargoes; it interacts with a YPxL motif in Doa4s catalytic domain to stimulate its deubiquitination activity. Rim20 may bind the ESCRT-III subunit Snf7, bringing the protease Rim13 (a YPxL-containing transcription factor) into proximity with Rim101, and promoting the proteolytic activation of Rim101. HD-PTP is encoded by the PTPN23 gene, a tumor suppressor gene candidate often absent in human kidney, breast, lung, and cervical tumors. HD-PTP has a C-terminal catalytically inactive tyrosine phosphatase domain.

Pssm-ID: 185746 [Multi-domain] Cd Length: 342 Bit Score: 45.03 E-value: 1.25e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 376 KHISQLEQKVRESELQVHSALLGRPAPFgDVCLLRLQELQRENTFLRAQFAQKTEALsREKIDLEKKLSASEVEVQLIRE 455
Cdd:cd08915   45 ASIDDLQKPENLPDSIQHSQEIIEEGGL-DNIEQSFKELSKLRQNVEELLQECEELL-EEEAAEDDQLRAKFGTLRWRRP 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 456 SLKVALQKHSEEVkkqeervkgrdkhiNNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELkSTE 535
Cdd:cd08915  123 SSDEAAKELYEKV--------------TKLRGYLEQASNSDNEVLQCYESIDPNLVLLCGGYKELKAFIPSPYPAL-DPE 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 536 LQEKVTELESLLEETQAICRDRETQLESLRQREAEFSSAghslqdkQSVEETSGEGPEVEMES-WQKQ---YDSLQKIVE 611
Cdd:cd08915  188 VSEVVSSLRPLLNEVSELEKERERFISELEIKSRNNDIL-------PKLITEYKKNGTTEFEDlFEEHlkkFDKDLTYVE 260

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966915597 612 KQQQKMDQLRSQVQSLEQEVAQEEGTSqalrEEAQRRDSALQQLRTAVKELS--VQN--------QDLIEKNLTLQEH 679
Cdd:cd08915  261 KTKKKQIELIKEIDAANQEFSQVKNSN----DSLDPREEALQDLEASYKKYLelKENlnegskfyNDLIEKVNRLLEE 334

Spc7

smart00787

Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...

411-546

5.55e-04

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.

Pssm-ID: 197874 [Multi-domain] Cd Length: 312 Bit Score: 42.70 E-value: 5.55e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   411 LQELQRENTFLRAQFAQkteaLSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRDKHINNLKKKCQ 490
Cdd:smart00787 153 LEGLKEDYKLLMKELEL----LNSIKPKLRDRKDALEEELRQLKQLEDELEDCDPTELDRAKEKLKKLLQEIMIKVKKLE 228

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   491 KESEQNREKQQRIETL----ERYLADLPTLEDHQKQSQQLKDSELKstELQEKVTELESL 546
Cdd:smart00787 229 ELEEELQELESKIEDLtnkkSELNTEIAEAEKKLEQCRGFTFKEIE--KLKEQLKLLQSL 286

Name

Accession

Description

Interval

E-value

Smc

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...

408-684

9.44e-18

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];

Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 88.46 E-value: 9.44e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 408 LLRLQELQREntflRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKvALQKHSEEVKKQEERVKGRdkhINNLKK 487
Cdd:COG1196  231 LLKLRELEAE----LEELEAELEELEAELEELEAELAELEAELEELRLELE-ELELELEEAQAEEYELLAE---LARLEQ 302

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 488 KCQKESEQNREKQQRIETLERYLADLptLEDHQKQSQQLKDSELKSTELQEKVTELESLLEETQAICRDRETQLESLRQR 567
Cdd:COG1196  303 DIARLEERRRELEERLEELEEELAEL--EEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEE 380

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 568 EAEFSSAGHSLQDKQSVEetsgegpevemeswQKQYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQR 647
Cdd:COG1196  381 LEELAEELLEALRAAAEL--------------AAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEE 446

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 966915597 648 RDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQ 684
Cdd:COG1196  447 AAEEEAELEEEEEALLELLAELLEEAALLEAALAELL 483

SMC_prok_B

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...

419-684

1.96e-13

Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 74.32 E-value: 1.96e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   419 TFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSE---EVKKQEERVKGRDKHINNLKKKCQKESEQ 495
Cdd:TIGR02168  662 TGGSAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEEleeELEQLRKELEELSRQISALRKDLARLEAE 741

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   496 NREKQQRIETLERYLADLptLEDHQKQSQQLKDSELKSTELQEKVTELESLLEETQAICRDRETQLESLRQREAEFSSAG 575
Cdd:TIGR02168  742 VEQLEERIAQLSKELTEL--EAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEA 819

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   576 HSLQDKQSVEETSGEGPEVEMESWQKQYDSLQKIVEK-------QQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRR 648
Cdd:TIGR02168  820 ANLRERLESLERRIAATERRLEDLEEQIEELSEDIESlaaeieeLEELIEELESELEALLNERASLEEALALLRSELEEL 899

                          250       260       270
                   ....*....|....*....|....*....|....*.
gi 966915597   649 DSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQ 684
Cdd:TIGR02168  900 SEELRELESKRSELRRELEELREKLAQLELRLEGLE 935

SMC_prok_B

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...

366-713

4.02e-13

Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 73.55 E-value: 4.02e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   366 EKELLIDKQRKHISQLEQKVRESELQVHSALLgrpapfgdvcllRLQELQRENTFLRAQFAQkteaLSREKIDLEKKLSa 445
Cdd:TIGR02168  667 KTNSSILERRREIEELEEKIEELEEKIAELEK------------ALAELRKELEELEEELEQ----LRKELEELSRQIS- 729

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   446 sEVEVQLIRESLKValQKHSEEVKKQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLptLEDHQKQSQQ 525
Cdd:TIGR02168  730 -ALRKDLARLEAEV--EQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQL--KEELKALREA 804

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   526 LKDSELKSTELQEKVTELESLLEETQAICRDRETQLESLRQR----EAEFSSAGHSLQDKQSVEETSgegpevemeswQK 601
Cdd:TIGR02168  805 LDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQieelSEDIESLAAEIEELEELIEEL-----------ES 873

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   602 QYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEaqrrdsaLQQLRTAVKELSVQNQDLIEKNLTLQEHLR 681
Cdd:TIGR02168  874 ELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRE-------LEELREKLAQLELRLEGLEVRIDNLQERLS 946

                          330       340       350
                   ....*....|....*....|....*....|..
gi 966915597   682 QAQpgsppsPDTAQLALELYQELASCLQDLQA 713
Cdd:TIGR02168  947 EEY------SLTLEEAEALENKIEDDEEEARR 972

SMC_prok_A

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...

410-684

9.80e-13

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]

Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 72.02 E-value: 9.80e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   410 RLQELQREntflRAQfAQKTEALSREKIDLEKKLSASEVE--------VQLIRESLKVALQKHSEEVKKQEERVKGRDKH 481
Cdd:TIGR02169  199 QLERLRRE----REK-AERYQALLKEKREYEGYELLKEKEalerqkeaIERQLASLEEELEKLTEEISELEKRLEEIEQL 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   482 INNLKKKCQK--ESEQNREKQQ------RIETLERYLADLPT-LEDHQKQSQQLkDSELKST-----ELQEKVTELESLL 547
Cdd:TIGR02169  274 LEELNKKIKDlgEEEQLRVKEKigeleaEIASLERSIAEKEReLEDAEERLAKL-EAEIDKLlaeieELEREIEEERKRR 352

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   548 EETQAICRDRETQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQKQYDSLQKIVEKQQQKMDQLRSQVQSL 627
Cdd:TIGR02169  353 DKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREINELKRELDRLQEELQRLSEELADLNAAIAGI 432

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 966915597   628 EQEVAQEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQ 684
Cdd:TIGR02169  433 EAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQ 489

Cast

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...

293-680

3.69e-11

Pssm-ID: 431111 [Multi-domain] Cd Length: 766 Bit Score: 66.77 E-value: 3.69e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  293 VWQPSPDTWHPREQSCELSTCRQQLEL-IRLQMEQMQLQNGAICHHPAAFAPSLPILEPAQWISILNSNEHLLKEKELL- 370
Cdd:pfam10174  57 VLKEQYRVTQEENQHLQLTIQALQDELrAQRDLNQLLQQDFTTSPVDGEDKFSTPELTEENFRRLQSEHERQAKELFLLr 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  371 ---------IDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLR---------------LQELQRENTFLR---- 422
Cdd:pfam10174 137 ktleemelrIETQKQTLGARDESIKKLLEMLQSKGLPKKSGEEDWERTRriaeaemqlghlevlLDQKEKENIHLReelh 216

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  423 -----AQFAQKTEALSR------EKI-DLEKKLSASEVEVQLIRESLKVALQKHSEEVkKQEERVKGRDKHINN----LK 486
Cdd:pfam10174 217 rrnqlQPDPAKTKALQTviemkdTKIsSLERNIRDLEDEVQMLKTNGLLHTEDREEEI-KQMEVYKSHSKFMKNkidqLK 295

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  487 KKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSqqLKDSELKSTELQEKVTELESLLEETQAICRDRETQLESLRQ 566
Cdd:pfam10174 296 QELSKKESELLALQTKLETLTNQNSDCKQHIEVLKES--LTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTE 373

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  567 REAEFSSAGHSLQDKQSVEETsgegpevEMESWQKQYDSLQKIVEKQQQKMDQLRSQVQSLEQE--------------VA 632
Cdd:pfam10174 374 EKSTLAGEIRDLKDMLDVKER-------KINVLQKKIENLQEQLRDKDKQLAGLKERVKSLQTDssntdtalttleeaLS 446

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 966915597  633 QEEGTSQALREEAQRRDsalQQLRTAVKELSVQNQDLIEKNLTLQEHL 680
Cdd:pfam10174 447 EKERIIERLKEQRERED---RERLEELESLKKENKDLKEKVSALQPEL 491

SMC_prok_B

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...

364-627

1.15e-10

Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 65.46 E-value: 1.15e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   364 LKEKELLIDKQRKHISQLEQKVRE--SELQVHSALLGRpapfgdvCLLRLQELQRENTFLRAQFAQKTEALS---REKID 438
Cdd:TIGR02168  262 LQELEEKLEELRLEVSELEEEIEElqKELYALANEISR-------LEQQKQILRERLANLERQLEELEAQLEeleSKLDE 334

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   439 LEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEE---RVKGRDKHINNLKKK---CQKESEQNREKQQRIETLERYLAD 512
Cdd:TIGR02168  335 LAEELAELEEKLEELKEELESLEAELEELEAELEElesRLEELEEQLETLRSKvaqLELQIASLNNEIERLEARLERLED 414

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   513 LPTLEDHQKQSQQLKDSELKSTELQEKVTELESLLEETQAICRDRETQLESLRQREAEFSSAGHSLQDKQSVEETSGEGP 592
Cdd:TIGR02168  415 RRERLQQEIEELLKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSL 494

                          250       260       270
                   ....*....|....*....|....*....|....*
gi 966915597   593 EVEMESWQKQYDSLqKIVEKQQQKMDQLRSQVQSL 627
Cdd:TIGR02168  495 ERLQENLEGFSEGV-KALLKNQSGLSGILGVLSEL 528

Mplasa_alph_rch

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...

352-676

1.58e-10

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.

Pssm-ID: 275316 [Multi-domain] Cd Length: 745 Bit Score: 64.66 E-value: 1.58e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  352 QWISILNSNEHL---LKEKELLIDKQRKHISQLEQKVRE--SELQVhsallgrpapfgdvclLRLQELQRENTFLRAQFA 426
Cdd:TIGR04523 254 QLNQLKDEQNKIkkqLSEKQKELEQNNKKIKELEKQLNQlkSEISD----------------LNNQKEQDWNKELKSELK 317

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  427 QKTEalsrEKIDLEKKLSASEvevQLIREsLKVALQKHSEEVKKQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETL 506
Cdd:TIGR04523 318 NQEK----KLEEIQNQISQNN---KIISQ-LNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNL 389

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  507 ERYLADLPTLEDHQKQSQQLKDSELKS--TELQEKVTELESLLEETQaicrDRETQLESLRQREAEFSSAGHSLQDKQSV 584
Cdd:TIGR04523 390 ESQINDLESKIQNQEKLNQQKDEQIKKlqQEKELLEKEIERLKETII----KNNSEIKDLTNQDSVKELIIKNLDNTRES 465

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  585 EETSGEGPEVEMESWQKQYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVKELsv 664
Cdd:TIGR04523 466 LETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDL-- 543

                         330
                  ....*....|..
gi 966915597  665 qNQDLIEKNLTL 676
Cdd:TIGR04523 544 -EDELNKDDFEL 554

EnvC

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...

426-660

2.73e-10

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];

Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 62.86 E-value: 2.73e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 426 AQKTEALSREKIDLEKKLSASEVEVQLI---RESLKVALQKHSEEVKKQEERVKGRDKHINNLKKKCQKESEQNREKQQR 502
Cdd:COG4942   19 ADAAAEAEAELEQLQQEIAELEKELAALkkeEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAE 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 503 IETLERYLADLptLEDHQKQSQQLKDSELKStelQEKVTELESLLEETQAICRDRETQLESLRQREAEfssaghsLQDKQ 582
Cdd:COG4942   99 LEAQKEELAEL--LRALYRLGRQPPLALLLS---PEDFLDAVRRLQYLKYLAPARREQAEELRADLAE-------LAALR 166

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966915597 583 SVEETSGEGPEVEMESWQKQYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVK 660
Cdd:COG4942  167 AELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTP 244

PRK03918

DNA double-strand break repair ATPase Rad50;

361-682

3.67e-10

DNA double-strand break repair ATPase Rad50;

Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 63.54 E-value: 3.67e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 361 EHLLKEKELLIDKQRKHISQLEQKVRESElqvhsallgrpapfgdvcllRLQELQRENTFLRAQFAQKTEALSRekidLE 440
Cdd:PRK03918 258 EEKIRELEERIEELKKEIEELEEKVKELK--------------------ELKEKAEEYIKLSEFYEEYLDELRE----IE 313

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 441 KKLSASEVEVQLIRESLKvALQKHSEEVKKQEERVKGRDKHINNLKKKcQKESEQNREKQQRIETLERYLADLPTledhQ 520
Cdd:PRK03918 314 KRLSRLEEEINGIEERIK-ELEEKEERLEELKKKLKELEKRLEELEER-HELYEEAKAKKEELERLKKRLTGLTP----E 387

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 521 KQSQQLKDSELKSTELQEKVTELESLLEETQAICRDRETQLESLRQREAEFSSAGHSLQdkqsvEETSGEgpevEMESWQ 600
Cdd:PRK03918 388 KLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAKGKCPVCGRELT-----EEHRKE----LLEEYT 458

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 601 KQYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEegtsqalrEEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHL 680
Cdd:PRK03918 459 AELKRIEKELKEIEEKERKLRKELRELEKVLKKE--------SELIKLKELAEQLKELEEKLKKYNLEELEKKAEEYEKL 530


                 ..
gi 966915597 681 RQ 682
Cdd:PRK03918 531 KE 532

Smc

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...

309-714

3.97e-10

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];

Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 63.42 E-value: 3.97e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 309 ELSTCRQQLELIRLQMEQMQLQngaichhpaafapslpilepaqwISILNSNEHLLKEKELLIDKQRKHisqLEQKVRES 388
Cdd:COG1196  261 ELAELEAELEELRLELEELELE-----------------------LEEAQAEEYELLAELARLEQDIAR---LEERRREL 314

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 389 ELQvhsallgrpapfgdvcLLRLQELQRENTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEV 468
Cdd:COG1196  315 EER----------------LEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAE 378

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 469 KKQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKstELQEKVTELESLLE 548
Cdd:COG1196  379 EELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEE--ALEEAAEEEAELEE 456

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 549 ETQAICRDRETQLESLRQREAEFSSAGHSLQDKQSVEETSgegpevemESWQKQYDSLQKIVEKQQQKMDQLR-SQVQSL 627
Cdd:COG1196  457 EEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLL--------LEAEADYEGFLEGVKAALLLAGLRGlAGAVAV 528

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 628 EQEVAQEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDLIEKnLTLQEHLRQAQPGSPPSPDTAQLALELYQELASC 707
Cdd:COG1196  529 LIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAKAGR-ATFLPLDKIRARAALAAALARGAIGAAVDLVASD 607


                 ....*..
gi 966915597 708 LQDLQAV 714
Cdd:COG1196  608 LREADAR 614

Mplasa_alph_rch

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...

411-681

1.20e-09

Pssm-ID: 275316 [Multi-domain] Cd Length: 745 Bit Score: 61.96 E-value: 1.20e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  411 LQELQRENTFLRAQFAQKTEALS--REKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRDKHINNLKKK 488
Cdd:TIGR04523 182 KLNIQKNIDKIKNKLLKLELLLSnlKKKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDE 261

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  489 CQKESEQNREKQQRIETLERYLADLPT--------LEDHQKQSQQLKDSELKS--TELQEKVTELESLLEETQAICRDRE 558
Cdd:TIGR04523 262 QNKIKKQLSEKQKELEQNNKKIKELEKqlnqlkseISDLNNQKEQDWNKELKSelKNQEKKLEEIQNQISQNNKIISQLN 341

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  559 TQLESLRQreaefssaghSLQDKQSVEETSGEgpevEMESWQKQYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEgts 638
Cdd:TIGR04523 342 EQISQLKK----------ELTNSESENSEKQR----ELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQE--- 404

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 966915597  639 qalrEEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLR 681
Cdd:TIGR04523 405 ----KLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIK 443

Smc

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...

497-684

1.24e-09

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];

Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 61.88 E-value: 1.24e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 497 REKQQRIETLE-------RYLADLPTLEDHQKQSQQLKDSELKS--TELQEKVTELESLLEETQAICRDRETQLESLRQR 567
Cdd:COG1196  196 GELERQLEPLErqaekaeRYRELKEELKELEAELLLLKLRELEAelEELEAELEELEAELEELEAELAELEAELEELRLE 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 568 EAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQKQYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQR 647
Cdd:COG1196  276 LEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEE 355

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 966915597 648 RDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQ 684
Cdd:COG1196  356 AEAELAEAEEALLEAEAELAEAEEELEELAEELLEAL 392

HMMR_N

pfam15905

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ...

374-616

2.05e-09

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.

Pssm-ID: 464932 [Multi-domain] Cd Length: 329 Bit Score: 59.82 E-value: 2.05e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  374 QRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLL--RLQELQRENTFLRAQFA-----QKTEALSREKIDLEKKLSAS 446
Cdd:pfam15905  92 QDKRLQALEEELEKVEAKLNAAVREKTSLSASVASLekQLLELTRVNELLKAKFSedgtqKKMSSLSMELMKLRNKLEAK 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  447 EVEVQLIRESLKVALQ------KHS-EEVKKQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDH 519
Cdd:pfam15905 172 MKEVMAKQEGMEGKLQvtqknlEHSkGKVAQLEEKLVSTEKEKIEEKSETEKLLEYITELSCVSEQVEKYKLDIAQLEEL 251

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  520 QKQsqqlKDSELKS--TELQEKVTELESLLEETQAICRDRETQLESLRQREaefssaghslqdkqsveETSGEGPEVEME 597
Cdd:pfam15905 252 LKE----KNDEIESlkQSLEEKEQELSKQIKDLNEKCKLLESEKEELLREY-----------------EEKEQTLNAELE 310

                         250
                  ....*....|....*....
gi 966915597  598 SWQKQYDSLQKIVEKQQQK 616
Cdd:pfam15905 311 ELKEKLTLEEQEHQKLQQK 329

SMC_prok_B

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...

479-684

2.13e-09

Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 61.23 E-value: 2.13e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   479 DKHINNLKKKCQKeSEQNREKQQRIETLERYLA--DLPTLEDHQKQSQ--------QLKDSELKSTELQEKVTELESLLE 548
Cdd:TIGR02168  199 ERQLKSLERQAEK-AERYKELKAELRELELALLvlRLEELREELEELQeelkeaeeELEELTAELQELEEKLEELRLEVS 277

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   549 ETQAICRDRETQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQKQYDSLQKIVEKQQQKMDQLRSQVQSLE 628
Cdd:TIGR02168  278 ELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLE 357

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 966915597   629 QEVAQEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQ 684
Cdd:TIGR02168  358 AELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLE 413

SMC_prok_A

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...

305-630

2.54e-09

Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 60.85 E-value: 2.54e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   305 EQSCELSTCRQQLELIRLQMEQMQLQNGAICHHPAAFAPSLPILEP--AQWISILNSNEHLLKEKELLIDKQRKHISQLE 382
Cdd:TIGR02169  706 ELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQeiENVKSELKELEARIEELEEDLHKLEEALNDLE 785

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   383 QKVRESelqvhsallgrpapfgdvcllRLQELQRENTFLRAQFAQKTEALSrekiDLEKKLSASEVEVQLIRESLKVALQ 462
Cdd:TIGR02169  786 ARLSHS---------------------RIPEIQAELSKLEEEVSRIEARLR----EIEQKLNRLTLEKEYLEKEIQELQE 840

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   463 KHSEevkkQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPT-LEDHQKQSQQLKDSELKSTELQEKVT 541
Cdd:TIGR02169  841 QRID----LKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKeRDELEAQLRELERKIEELEAQIEKKR 916

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   542 ELESLLEETQAICRDRETQLESLRQREAEFSSAGHSLQDKQSV-----EETSGEGP-----EVEMESWQKQYDSLQKIVE 611
Cdd:TIGR02169  917 KRLSELKAKLEALEEELSEIEDPKGEDEEIPEEELSLEDVQAElqrveEEIRALEPvnmlaIQEYEEVLKRLDELKEKRA 996

                          330
                   ....*....|....*....
gi 966915597   612 KQQQKMDQLRSQVQSLEQE 630
Cdd:TIGR02169  997 KLEEERKAILERIEEYEKK 1015

GumC

COG3206

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];

493-713

1.59e-08

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 442439 [Multi-domain] Cd Length: 687 Bit Score: 58.10 E-value: 1.59e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 493 SEQNREKQQRIETLERYLADLptledhqKQSQQLKDSELKSTELQEKVTELESLLEETQAICRDRETQLESLRQREAEFS 572
Cdd:COG3206  181 EEQLPELRKELEEAEAALEEF-------RQKNGLVDLSEEAKLLLQQLSELESQLAEARAELAEAEARLAALRAQLGSGP 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 573 SAGHSLQDKQSVEETSGEgpEVEMESwqkQYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQE-EGTSQALREEAQRRDSA 651
Cdd:COG3206  254 DALPELLQSPVIQQLRAQ--LAELEA---ELAELSARYTPNHPDVIALRAQIAALRAQLQQEaQRILASLEAELEALQAR 328

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966915597 652 LQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAqpgsppspDTAQlalELYQELASCLQDLQA 713
Cdd:COG3206  329 EASLQAQLAQLEARLAELPELEAELRRLEREV--------EVAR---ELYESLLQRLEEARL 379

EnvC

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...

459-684

2.05e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];

Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 57.08 E-value: 2.05e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 459 VALQKHSEEVKKQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLptLEDHQKQSQQLKDSELKSTELQE 538
Cdd:COG4942   13 LAAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAAL--ARRIRALEQELAALEAELAELEK 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 539 KVTELESLLEETQAICRDRETQLESLRQREA--------EFSSAGHSLQDKQSVeetsgegpeveMESWQKQYDSLQKIV 610
Cdd:COG4942   91 EIAELRAELEAQKEELAELLRALYRLGRQPPlalllspeDFLDAVRRLQYLKYL-----------APARREQAEELRADL 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966915597 611 EKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQ 684
Cdd:COG4942  160 AELAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLE 233

SMC_prok_A

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...

466-776

3.26e-08

Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 57.39 E-value: 3.26e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   466 EEVKKQEERVKGRDKHINNLKKKCQKESEQN---REKQQRIETLERYLAdLPTLEDHQKQSQQLkDSELksTELQEKVTE 542
Cdd:TIGR02169  180 EEVEENIERLDLIIDEKRQQLERLRREREKAeryQALLKEKREYEGYEL-LKEKEALERQKEAI-ERQL--ASLEEELEK 255

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   543 LESLLEETQAICRDRETQLESLRQREAEFSSaGHSLQDKQSVEETSGEGPEVE--MESWQKQYDSLQKIVEKQQQKMDQL 620
Cdd:TIGR02169  256 LTEEISELEKRLEEIEQLLEELNKKIKDLGE-EEQLRVKEKIGELEAEIASLErsIAEKERELEDAEERLAKLEAEIDKL 334

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   621 RSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQPGSPPSPDTAQLALEL 700
Cdd:TIGR02169  335 LAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREINELKRELDRLQEE 414

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966915597   701 YQELASCLQDLQAVcsivtqraqghdpnlslLLGIHSQHPETQLDLQ-KPDVIKRKLEEVQQLRRDIEDLRTTMSDR 776
Cdd:TIGR02169  415 LQRLSEELADLNAA-----------------IAGIEAKINELEEEKEdKALEIKKQEWKLEQLAADLSKYEQELYDL 474

YhaN

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];

420-646

3.27e-08

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];

Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 57.08 E-value: 3.27e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 420 FLRAQFAqktEALSREKIDLEK----KLSASEVEVQLIRESLKVALQKHsEEVKKQEERVKGRDKHINNLKKkcqkeseQ 495
Cdd:COG4717   42 FIRAMLL---ERLEKEADELFKpqgrKPELNLKELKELEEELKEAEEKE-EEYAELQEELEELEEELEELEA-------E 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 496 NREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKSTELQEKVTELESLLEEtqaiCRDRETQLESLRQREAEfssag 575
Cdd:COG4717  111 LEELREELEKLEKLLQLLPLYQELEALEAELAELPERLEELEERLEELRELEEE----LEELEAELAELQEELEE----- 181

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 966915597 576 hsLQDKQSVEEtsgegpEVEMESWQKQYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQ 646
Cdd:COG4717  182 --LLEQLSLAT------EEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEER 244

PRK10929

putative mechanosensitive channel protein; Provisional

421-689

3.73e-08

putative mechanosensitive channel protein; Provisional

Pssm-ID: 236798 [Multi-domain] Cd Length: 1109 Bit Score: 57.37 E-value: 3.73e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  421 LRAQFAQKTEALSREKIDLEKKLSASEVEVQLiresLKVALQKHSEEVKKQEERVKGRDKHiNNLKKKCQKESEQNREkq 500
Cdd:PRK10929   80 LSAELRQQLNNERDEPRSVPPNMSTDALEQEI----LQVSSQLLEKSRQAQQEQDRAREIS-DSLSQLPQQQTEARRQ-- 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  501 qrIETLERYLADLPTLEDHQKQSQqLKDSELKSTELQEKVTELEslLEE-----TQAICRDR------------------ 557
Cdd:PRK10929  153 --LNEIERRLQTLGTPNTPLAQAQ-LTALQAESAALKALVDELE--LAQlsannRQELARLRselakkrsqqldaylqal 227

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  558 ETQLESLRQREAEfssagHSLQDKQSVEETSGEGPEVEMESWQKQYDsLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGT 637
Cdd:PRK10929  228 RNQLNSQRQREAE-----RALESTELLAEQSGDLPKSIVAQFKINRE-LSQALNQQAQRMDLIASQQRQAASQTLQVRQA 301

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966915597  638 SQALREEAQRRDSA-------------------LQQLRTAVKELSVQN---QDLIEKnltLQEHLRQAQPGSPP 689
Cdd:PRK10929  302 LNTLREQSQWLGVSnalgealraqvarlpempkPQQLDTEMAQLRVQRlryEDLLNK---QPQLRQIRQADGQP 372

PHA02562

endonuclease subunit; Provisional

472-679

4.30e-08

endonuclease subunit; Provisional

Pssm-ID: 222878 [Multi-domain] Cd Length: 562 Bit Score: 56.56 E-value: 4.30e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 472 EERVKGRDKHINNLKKKcqkESEQNREKQQRIETLeryladLPTLEDHQKQSQQLKDSELKSTELQEKVTELESLLEETQ 551
Cdd:PHA02562 194 QQQIKTYNKNIEEQRKK---NGENIARKQNKYDEL------VEEAKTIKAEIEELTDELLNLVMDIEDPSAALNKLNTAA 264

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 552 AicrDRETQLESLrQREAEFSSAGHS----LQDKQSVEETSGEGPEvEMESWQKQYDSLQKIVEKQQQKMDQLRSQ---V 624
Cdd:PHA02562 265 A---KIKSKIEQF-QKVIKMYEKGGVcptcTQQISEGPDRITKIKD-KLKELQHSLEKLDTAIDELEEIMDEFNEQskkL 339

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 966915597 625 QSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAV----KELSVQNQDLIEKNLTLQEH 679
Cdd:PHA02562 340 LELKNKISTNKQSLITLVDKAKKVKAAIEELQAEFvdnaEELAKLQDELDKIVKTKSEL 398

SMC_prok_A

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...

491-768

4.82e-08

Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 57.00 E-value: 4.82e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   491 KESEQNREKQQRIETLERYLADLPT---------------------------------LEDHQKQSQQLKDSELKSTELQ 537
Cdd:TIGR02169  671 SEPAELQRLRERLEGLKRELSSLQSelrrienrldelsqelsdasrkigeiekeieqlEQEEEKLKERLEELEEDLSSLE 750

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   538 EKVTELESLLEETQAICRDRETQLESLRQREAEFSSAghslQDKQSVEETSGEGPEVEME--SWQKQYDSLQKIVEKQQQ 615
Cdd:TIGR02169  751 QEIENVKSELKELEARIEELEEDLHKLEEALNDLEAR----LSHSRIPEIQAELSKLEEEvsRIEARLREIEQKLNRLTL 826

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   616 KMDQLRSQVQSLEQ----------EVAQEEGTSQALREEAQRRdsaLQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQP 685
Cdd:TIGR02169  827 EKEYLEKEIQELQEqridlkeqikSIEKEIENLNGKKEELEEE---LEELEAALRDLESRLGDLKKERDELEAQLRELER 903

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   686 GsppspdTAQLALElYQELASCLQDLQAVCSIVTQRAQGHDPNLSLLLGIhsqhPETQLDLQKpdvIKRKLEEVQQLRRD 765
Cdd:TIGR02169  904 K------IEELEAQ-IEKKRKRLSELKAKLEALEEELSEIEDPKGEDEEI----PEEELSLED---VQAELQRVEEEIRA 969


                   ...
gi 966915597   766 IED 768
Cdd:TIGR02169  970 LEP 972

CALCOCO1

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...

410-678

5.41e-08

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.

Pssm-ID: 462303 [Multi-domain] Cd Length: 488 Bit Score: 56.06 E-value: 5.41e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  410 RLQELQRE-NTFLRAQFAQK------TEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRDKhi 482
Cdd:pfam07888  35 RLEECLQErAELLQAQEAANrqrekeKERYKRDREQWERQRRELESRVAELKEELRQSREKHEELEEKYKELSASSEE-- 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  483 nnLKKKCQKESEQNREKQQRIETLERYL-----------ADLPTLEDHQKQS-QQLKDSELKSTELQEKvteleslLEET 550
Cdd:pfam07888 113 --LSEEKDALLAQRAAHEARIRELEEDIktltqrvlereTELERMKERAKKAgAQRKEEEAERKQLQAK-------LQQT 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  551 QAICRDRETQLESLRQREAEFSSAGHSLQDKQSVEE---TSGEGPEVEMESWQKQYDSLQKIVEKQQQKMDQLRSQVQSL 627
Cdd:pfam07888 184 EEELRSLSKEFQELRNSLAQRDTQVLQLQDTITTLTqklTTAHRKEAENEALLEELRSLQERLNASERKVEGLGEELSSM 263

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 966915597  628 eqevaqeegtsQALREEAQrrdSALQQLRTAVKELSVQnqdLIEKNLTLQE 678
Cdd:pfam07888 264 -----------AAQRDRTQ---AELHQARLQAAQLTLQ---LADASLALRE 297

SCP-1

pfam05483

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...

361-634

6.30e-08

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.

Pssm-ID: 114219 [Multi-domain] Cd Length: 787 Bit Score: 56.27 E-value: 6.30e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  361 EHLLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQeLQRENTFLRA-----QFAQKT-EALSR 434
Cdd:pfam05483 253 ENKMKDLTFLLEESRDKANQLEEKTKLQDENLKELIEKKDHLTKELEDIKMS-LQRSMSTQKAleedlQIATKTiCQLTE 331

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  435 EKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRDKHINNLKKKCQKESEQNRE-------KQQRIETLE 507
Cdd:pfam05483 332 EKEAQMEELNKAKAAHSFVVTEFEATTCSLEELLRTEQQRLEKNEDQLKIITMELQKKSSELEEmtkfknnKEVELEELK 411

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  508 RYLADLPTLEDHQKQSQQLKDsELKSTE------LQEKVTELESLLEETQAI----------CRDRETQLESLRQREAEF 571
Cdd:pfam05483 412 KILAEDEKLLDEKKQFEKIAE-ELKGKEqeliflLQAREKEIHDLEIQLTAIktseehylkeVEDLKTELEKEKLKNIEL 490

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  572 SSAGH--SLQDKQSVEETSGEGPEV-----EMESWQKQYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQE 634
Cdd:pfam05483 491 TAHCDklLLENKELTQEASDMTLELkkhqeDIINCKKQEERMLKQIENLEEKEMNLRDELESVREEFIQK 560

SMC_prok_A

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...

361-678

9.13e-08

Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 55.84 E-value: 9.13e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   361 EHLLKEKELLIDKQRK---HISQLEQKVRESELQVHSALLgrpapfgdvcllRLQELQRENTFLRAQFA----------Q 427
Cdd:TIGR02169  684 EGLKRELSSLQSELRRienRLDELSQELSDASRKIGEIEK------------EIEQLEQEEEKLKERLEeleedlssleQ 751

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   428 KTEALSREKIDLEKKLSASE---VEVQLIRESLKVAL--------QKHSEEVKKQEERVKGRDKHINNLKKKCQKESEQN 496
Cdd:TIGR02169  752 EIENVKSELKELEARIEELEedlHKLEEALNDLEARLshsripeiQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYL 831

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   497 REKqqrIETLERYLADLptledhqkqSQQLKDSELKSTELQEKVTELESLLEETQAICRDRETQLESLRQREAEFSSAGH 576
Cdd:TIGR02169  832 EKE---IQELQEQRIDL---------KEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLR 899

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   577 SLQDKQSVEETsgegpevemeswqkQYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEE---------GTSQALREEAQR 647
Cdd:TIGR02169  900 ELERKIEELEA--------------QIEKKRKRLSELKAKLEALEEELSEIEDPKGEDEeipeeelslEDVQAELQRVEE 965

                          330       340       350
                   ....*....|....*....|....*....|....*....
gi 966915597   648 RDSAL--------QQLRTAVKELSvqnqDLIEKNLTLQE 678
Cdd:TIGR02169  966 EIRALepvnmlaiQEYEEVLKRLD----ELKEKRAKLEE 1000

CALCOCO1

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...

372-662

1.08e-07

Pssm-ID: 462303 [Multi-domain] Cd Length: 488 Bit Score: 55.29 E-value: 1.08e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  372 DKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQ 451
Cdd:pfam07888  60 EKERYKRDREQWERQRRELESRVAELKEELRQSREKHEELEEKYKELSASSEELSEEKDALLAQRAAHEARIRELEEDIK 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  452 lireslkvALQKHSEEVKKQEERVKGRDKHINNLKKKCQKESEQNREK-QQRIETLERYLADLPTLEDHQKQ----SQQL 526
Cdd:pfam07888 140 --------TLTQRVLERETELERMKERAKKAGAQRKEEEAERKQLQAKlQQTEEELRSLSKEFQELRNSLAQrdtqVLQL 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  527 KDS----ELKSTELQEKVTELESLLEETQAIcRDR----ETQLESLRqreAEFSSAGhSLQDKQSVE---------ETSG 589
Cdd:pfam07888 212 QDTittlTQKLTTAHRKEAENEALLEELRSL-QERlnasERKVEGLG---EELSSMA-AQRDRTQAElhqarlqaaQLTL 286

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  590 EGPEVEME------SWQKQYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREE-AQRRDSALQQLRTAVKEL 662
Cdd:pfam07888 287 QLADASLAlregraRWAQERETLQQSAEADKDRIEKLSAELQRLEERLQEERMEREKLEVElGREKDCNRVQLSESRREL 366

rad50

TIGR00606

rad50; All proteins in this family for which functions are known are involvedin recombination, ...

409-780

1.19e-07

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).

Pssm-ID: 129694 [Multi-domain] Cd Length: 1311 Bit Score: 55.44 E-value: 1.19e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   409 LRLQELQRENTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLirESLKVALQKHSEEVKKQEERVKGRDKHINNLKKK 488
Cdd:TIGR00606  598 KELASLEQNKNHINNELESKEEQLSSYEDKLFDVCGSQDEESDL--ERLKEEIEKSSKQRAMLAGATAVYSQFITQLTDE 675

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   489 -------CQKESEQNREKQQRIETLERYLADLPTledhqkqsqQLKDSELKSTELQEKVTELESLLEETQAICRDRETQL 561
Cdd:TIGR00606  676 nqsccpvCQRVFQTEAELQEFISDLQSKLRLAPD---------KLKSTESELKKKEKRRDEMLGLAPGRQSIIDLKEKEI 746

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   562 ESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQkqydSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEG----- 636
Cdd:TIGR00606  747 PELRNKLQKVNRDIQRLKNDIEEQETLLGTIMPEEESAK----VCLTDVTIMERFQMELKDVERKIAQQAAKLQGsdldr 822

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   637 TSQALREEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQPGSPPSPDTAQLALELYQELASCLQDLQAVCS 716
Cdd:TIGR00606  823 TVQQVNQEKQEKQHELDTVVSKIELNRKLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQRRQQFEEQLVELSTEVQSLIR 902

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966915597   717 IVTQRAQGHDPNLSLL--------LGIHSQHPETQLDLQKPDVIKRKLEEVQQLRRDIEDLRTTMSDRYAQD 780
Cdd:TIGR00606  903 EIKDAKEQDSPLETFLekdqqekeELISSKETSNKKAQDKVNDIKEKVKNIHGYMKDIENKIQDGKDDYLKQ 974

PRK03918

DNA double-strand break repair ATPase Rad50;

427-671

1.21e-07

DNA double-strand break repair ATPase Rad50;

Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 55.46 E-value: 1.21e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 427 QKTEALSREKIDLEKKLSASEVEVQLIRESLKvALQKHSEEVKKQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETL 506
Cdd:PRK03918 200 KELEEVLREINEISSELPELREELEKLEKEVK-ELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEEL 278

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 507 ERYLADLPTLEDHQKQSQQLK----DSELKSTELQEKVTELESLLEETQAICRDRETQLESLRQREAEFSsaghSLQDKQ 582
Cdd:PRK03918 279 EEKVKELKELKEKAEEYIKLSefyeEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLK----ELEKRL 354

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 583 SVEETSGEGPE------VEMESWQKQYDSLQkiVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLR 656
Cdd:PRK03918 355 EELEERHELYEeakakkEELERLKKRLTGLT--PEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELK 432

                        250
                 ....*....|....*
gi 966915597 657 TAVKELSVQNQDLIE 671
Cdd:PRK03918 433 KAKGKCPVCGRELTE 447

PRK02224

DNA double-strand break repair Rad50 ATPase;

427-770

1.52e-07

DNA double-strand break repair Rad50 ATPase;

Pssm-ID: 179385 [Multi-domain] Cd Length: 880 Bit Score: 55.05 E-value: 1.52e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 427 QKTEALSREKIDLEKKLSASEVEvqliRESLKvalqkhsEEVKKQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETL 506
Cdd:PRK02224 251 EELETLEAEIEDLRETIAETERE----REELA-------EEVRDLRERLEELEEERDDLLAEAGLDDADAEAVEARREEL 319

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 507 ERYLADL-PTLEDHQKQSQQL-----------KDSELKSTELQEKVTELESLLEETQAICRDRETQLESLRQR----EAE 570
Cdd:PRK02224 320 EDRDEELrDRLEECRVAAQAHneeaeslredaDDLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEieelRER 399

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 571 FSSAGHSLQD----KQSVEETSGE--GPEVEMESWQKqydSLQKIVEKQQQ---------------------KMDQLRSQ 623
Cdd:PRK02224 400 FGDAPVDLGNaedfLEELREERDElrEREAELEATLR---TARERVEEAEAlleagkcpecgqpvegsphveTIEEDRER 476

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 624 VQSLEQEVAQeegtsqaLREEAQRRDSALQQLRTAVkELSVQNQDLIEKNLTLQEHLRQAQPGSPPSPDTAQLALELYQE 703
Cdd:PRK02224 477 VEELEAELED-------LEEEVEEVEERLERAEDLV-EAEDRIERLEERREDLEELIAERRETIEEKRERAEELRERAAE 548

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966915597 704 LASCLQDLQAVCSIVTQRAQGHdpnLSLLLGIHSQHPETQLDLQKPDVIKRKLEEVQQLRRDIEDLR 770
Cdd:PRK02224 549 LEAEAEEKREAAAEAEEEAEEA---REEVAELNSKLAELKERIESLERIRTLLAAIADAEDEIERLR 612

Mplasa_alph_rch

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...

428-684

2.43e-07

Pssm-ID: 275316 [Multi-domain] Cd Length: 745 Bit Score: 54.26 E-value: 2.43e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  428 KTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEE------VKKQEERVKGRDKHINNLKKKCQKESEQNREKQQ 501
Cdd:TIGR04523 160 KYNDLKKQKEELENELNLLEKEKLNIQKNIDKIKNKLLKLelllsnLKKKIQKNKSLESQISELKKQNNQLKDNIEKKQQ 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  502 RIETLERyladlpTLEDHQKQSQQLKDSELK-STELQEKVTELES---LLEETQAICRDRETQLESLR-QREAEFSSAGH 576
Cdd:TIGR04523 240 EINEKTT------EISNTQTQLNQLKDEQNKiKKQLSEKQKELEQnnkKIKELEKQLNQLKSEISDLNnQKEQDWNKELK 313

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  577 SlqdkqsveetsgegpevEMESWQKQYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLR 656
Cdd:TIGR04523 314 S-----------------ELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLK 376

                         250       260
                  ....*....|....*....|....*...
gi 966915597  657 TAVKELSVQNQDLIEKNLTLQEHLRQAQ 684
Cdd:TIGR04523 377 KENQSYKQEIKNLESQINDLESKIQNQE 404

PRK03918

DNA double-strand break repair ATPase Rad50;

361-643

3.34e-07

DNA double-strand break repair ATPase Rad50;

Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 53.91 E-value: 3.34e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 361 EHLLKEKELLIDKQRKHISQLEQKVRESELQVhSALLGRpapfgdvcLLRLQELqrentflraqfAQKTEALSREKIDLE 440
Cdd:PRK03918 192 EELIKEKEKELEEVLREINEISSELPELREEL-EKLEKE--------VKELEEL-----------KEEIEELEKELESLE 251

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 441 KKLSASEVEVQLIRESLKvALQKHSEEVKKQEERVkgrdKHINNLKKKCQKESEQNREKQQRIETLERYLADLptledhq 520
Cdd:PRK03918 252 GSKRKLEEKIRELEERIE-ELKKEIEELEEKVKEL----KELKEKAEEYIKLSEFYEEYLDELREIEKRLSRL------- 319

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 521 kqSQQLKDSELKSTELQEKVTELESLLEETQAICRDretqLESLRQREAEFSSAghsLQDKQSVEETSGEGPEVEMESWQ 600
Cdd:PRK03918 320 --EEEINGIEERIKELEEKEERLEELKKKLKELEKR----LEELEERHELYEEA---KAKKEELERLKKRLTGLTPEKLE 390

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 966915597 601 KQYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALRE 643
Cdd:PRK03918 391 KELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKK 433

COG4913

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];

497-684

3.34e-07

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];

Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 54.15 E-value: 3.34e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  497 REKQQRIETLERYLADLptleDHQKQSQQLKDSELKSTELQEKVTELESLLEETQAICRDRETQLESLRQREAEFssagh 576
Cdd:COG4913   258 RELAERYAAARERLAEL----EYLRAALRLWFAQRRLELLEAELEELRAELARLEAELERLEARLDALREELDEL----- 328

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  577 slqdKQSVEETSGEgpevEMESWQKQYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLR 656
Cdd:COG4913   329 ----EAQIRGNGGD----RLEQLEREIERLERELEERERRRARLEALLAALGLPLPASAEEFAALRAEAAALLEALEEEL 400

                         170       180
                  ....*....|....*....|....*...
gi 966915597  657 TAVKELSVQNQDLIEKnltLQEHLRQAQ 684
Cdd:COG4913   401 EALEEALAEAEAALRD---LRRELRELE 425

235kDa-fam

TIGR01612

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...

428-709

3.45e-07

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.

Pssm-ID: 130673 [Multi-domain] Cd Length: 2757 Bit Score: 54.29 E-value: 3.45e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   428 KTEAlSREKIDLEK-----KLSASEVEVqLIRESLKVALQKHSEEVKKQEERVKgrdKHINNLKKKCQKESEQNREKQQR 502
Cdd:TIGR01612 1499 KDEA-DKNAKAIEKnkelfEQYKKDVTE-LLNKYSALAIKNKFAKTKKDSEIII---KEIKDAHKKFILEAEKSEQKIKE 1573

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   503 IETLERYLADLPTLEDH--------QKQSQQLKDSELKSTELQEKVTELeslLEETQAIcrDRETQLESLRQREAEFSSA 574
Cdd:TIGR01612 1574 IKKEKFRIEDDAAKNDKsnkaaidiQLSLENFENKFLKISDIKKKINDC---LKETESI--EKKISSFSIDSQDTELKEN 1648

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   575 GHSLQDKQSVeetsgegpeveMESWQKQydslQKIVEKQQQKMDQLRSQVQSLEQEVAQ-----EEGTSQALREEAQRRD 649
Cdd:TIGR01612 1649 GDNLNSLQEF-----------LESLKDQ----KKNIEDKKKELDELDSEIEKIEIDVDQhkknyEIGIIEKIKEIAIANK 1713

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966915597   650 SALQQLRTAVKEL------SVQNQDL--IEKNLTLQEHLRQAQpgsppspDTAQLALELYQELASCLQ 709
Cdd:TIGR01612 1714 EEIESIKELIEPTienlisSFNTNDLegIDPNEKLEEYNTEIG-------DIYEEFIELYNIIAGCLE 1774

PTZ00121

MAEBL; Provisional

422-703

3.90e-07

MAEBL; Provisional

Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 53.99 E-value: 3.90e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  422 RAQFAQKTEALSREKIDLEKKlsASEV----EVQLIRESLKVA--LQKHSEEVKKQEERVKGRD--KHINNLKKKCQkES 493
Cdd:PTZ00121 1406 KADELKKAAAAKKKADEAKKK--AEEKkkadEAKKKAEEAKKAdeAKKKAEEAKKAEEAKKKAEeaKKADEAKKKAE-EA 1482

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  494 EQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSE-------LKSTELQEKVTELESLLEETQAicrDRETQLESLRQ 566
Cdd:PTZ00121 1483 KKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEeakkadeAKKAEEAKKADEAKKAEEKKKA---DELKKAEELKK 1559

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  567 REA--EFSSAGHSLQDKQSVEETSGEGPEVE---MESWQKQYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQAL 641
Cdd:PTZ00121 1560 AEEkkKAEEAKKAEEDKNMALRKAEEAKKAEearIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLK 1639

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966915597  642 REEAQRRDSAlQQLRTAVKELSVQNQDLIEKNltlQEHLRQAQPGSPPSPDTAQLALELYQE 703
Cdd:PTZ00121 1640 KKEAEEKKKA-EELKKAEEENKIKAAEEAKKA---EEDKKKAEEAKKAEEDEKKAAEALKKE 1697

PRK02224

DNA double-strand break repair Rad50 ATPase;

498-673

4.17e-07

DNA double-strand break repair Rad50 ATPase;

Pssm-ID: 179385 [Multi-domain] Cd Length: 880 Bit Score: 53.89 E-value: 4.17e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 498 EKQQRIETLERYLADLPT----LEDHQKQSQQLKDSELKSTELQEKVTELESLLEETQAICRDRETQLESLRQREAEFSS 573
Cdd:PRK02224 472 EDRERVEELEAELEDLEEeveeVEERLERAEDLVEAEDRIERLEERREDLEELIAERRETIEEKRERAEELRERAAELEA 551

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 574 AGhslqdkqsvEETSGEGPEVEMESwqkqyDSLQKIVEKQQQKMDQLRSQVQSLEQEVaqeegTSQALREEAQRRDSALQ 653
Cdd:PRK02224 552 EA---------EEKREAAAEAEEEA-----EEAREEVAELNSKLAELKERIESLERIR-----TLLAAIADAEDEIERLR 612

                        170       180
                 ....*....|....*....|.
gi 966915597 654 QLRTAVKELSVQNQD-LIEKN 673
Cdd:PRK02224 613 EKREALAELNDERRErLAEKR 633

DUF5401

pfam17380

Family of unknown function (DUF5401); This is a family of unknown function found in ...

361-663

5.42e-07

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.

Pssm-ID: 375164 [Multi-domain] Cd Length: 722 Bit Score: 53.20 E-value: 5.42e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  361 EHLLKEKE-LLIDKQRKHISQLEQKVRESELQVHSALLgrpAPFGDVCLLRLQELQRentflraqfaQKTEALSREKIDL 439
Cdd:pfam17380 299 ERLRQEKEeKAREVERRRKLEEAEKARQAEMDRQAAIY---AEQERMAMERERELER----------IRQEERKRELERI 365

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  440 EKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKgrdkhinnlKKKCQKESEQNREKQQRIEtleryladlptLEDH 519
Cdd:pfam17380 366 RQEEIAMEISRMRELERLQMERQQKNERVRQELEAAR---------KVKILEEERQRKIQQQKVE-----------MEQI 425

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  520 QKQSQQLKDSELKSTElQEKVTELESLLEETQaicrDRETQLESLRQREAEFSSAGHSL----QDKQSVEETSGEGPEVE 595
Cdd:pfam17380 426 RAEQEEARQREVRRLE-EERAREMERVRLEEQ----ERQQQVERLRQQEEERKRKKLELekekRDRKRAEEQRRKILEKE 500

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 966915597  596 MESWQK---QYDSLQKIVEKQQQkmDQLRSQVQSLEQEVAQEEGTSQalrEEAQRRDSALQQLRTAVKELS 663
Cdd:pfam17380 501 LEERKQamiEEERKRKLLEKEME--ERQKAIYEEERRREAEEERRKQ---QEMEERRRIQEQMRKATEERS 566

PRK03918

DNA double-strand break repair ATPase Rad50;

423-672

6.23e-07

DNA double-strand break repair ATPase Rad50;

Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 53.14 E-value: 6.23e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 423 AQFAQKTEALSREKIDLEKKLSASEV---------EVQLIRESLKV----ALQKHSEEVKKQEERVKGRDKHINNLKKKC 489
Cdd:PRK03918 469 KEIEEKERKLRKELRELEKVLKKESEliklkelaeQLKELEEKLKKynleELEKKAEEYEKLKEKLIKLKGEIKSLKKEL 548

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 490 QKESEQNREK---QQRIETLERYLADLptledhQKQSQQLKDSELKstELQEKVTELESLLE---ETQAICRDRETQLES 563
Cdd:PRK03918 549 EKLEELKKKLaelEKKLDELEEELAEL------LKELEELGFESVE--ELEERLKELEPFYNeylELKDAEKELEREEKE 620

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 564 LRQREAEFSSAGHSLQD-KQSVEETSGEGPEVEMESWQKQYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALR 642
Cdd:PRK03918 621 LKKLEEELDKAFEELAEtEKRLEELRKELEELEKKYSEEEYEELREEYLELSRELAGLRAELEELEKRREEIKKTLEKLK 700

                        250       260       270
                 ....*....|....*....|....*....|...
gi 966915597 643 EEAQRRDSA---LQQLRTAVKELsvqnQDLIEK 672
Cdd:PRK03918 701 EELEEREKAkkeLEKLEKALERV----EELREK 729

MukB

COG3096

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...

408-656

1.75e-06

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];

Pssm-ID: 442330 [Multi-domain] Cd Length: 1470 Bit Score: 51.88 E-value: 1.75e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  408 LLRLQELQRENTFLR-AQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKvALQKHSEEVKKQEERVKGRdkhinnlk 486
Cdd:COG3096   428 LCGLPDLTPENAEDYlAAFRAKEQQATEEVLELEQKLSVADAARRQFEKAYE-LVCKIAGEVERSQAWQTAR-------- 498

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  487 kkcqKESEQNREKQ---QRIETLERYLADLPTLEDHQKQSQQLKDSELKSTELQ-EKVTELESLLEETQAICRDRETQLE 562
Cdd:COG3096   499 ----ELLRRYRSQQalaQRLQQLRAQLAELEQRLRQQQNAERLLEEFCQRIGQQlDAAEELEELLAELEAQLEELEEQAA 574

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  563 SLRQREAEFSSAGHSLQDKQsvEETSGEGPEvemesWQKQYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALR 642
Cdd:COG3096   575 EAVEQRSELRQQLEQLRARI--KELAARAPA-----WLAAQDALERLREQSGEALADSQEVTAAMQQLLEREREATVERD 647

                         250
                  ....*....|....
gi 966915597  643 EEAQRRDSALQQLR 656
Cdd:COG3096   648 ELAARKQALESQIE 661

YhaN

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];

453-682

1.88e-06

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];

Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 51.31 E-value: 1.88e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 453 IRESLKVALQKHSEEVKKQEERVKGRdKHINNLK--KKCQKESEQNREKQQRIETLERYLADLptledhqkqSQQLKDSE 530
Cdd:COG4717   39 LLAFIRAMLLERLEKEADELFKPQGR-KPELNLKelKELEEELKEAEEKEEEYAELQEELEEL---------EEELEELE 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 531 LKSTELQEKVTELESLLEetqaiCRDRETQLESLRQREAEFSSAGHSLQDKQSveetsgegpevEMESWQKQYDSLQKIV 610
Cdd:COG4717  109 AELEELREELEKLEKLLQ-----LLPLYQELEALEAELAELPERLEELEERLE-----------ELRELEEELEELEAEL 172

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966915597 611 EKQQQKMDQLRSQV-QSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVKELSvQNQDLIEKNLTLQEHLRQ 682
Cdd:COG4717  173 AELQEELEELLEQLsLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELE-EELEQLENELEAAALEER 244

Mplasa_alph_rch

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...

411-644

2.06e-06

Pssm-ID: 275316 [Multi-domain] Cd Length: 745 Bit Score: 51.56 E-value: 2.06e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  411 LQELQRENtflrAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVaLQKHSEEVKKQEERVKG----RDKHINNLK 486
Cdd:TIGR04523 372 IEKLKKEN----QSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKK-LQQEKELLEKEIERLKEtiikNNSEIKDLT 446

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  487 KKCQ------KESEQNREKQ-QRIETLER-YLADLPTLEDHQKQSQQlKDSELKS-----TELQEKVTELE---SLLEET 550
Cdd:TIGR04523 447 NQDSvkeliiKNLDNTRESLeTQLKVLSRsINKIKQNLEQKQKELKS-KEKELKKlneekKELEEKVKDLTkkiSSLKEK 525

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  551 QAICRDRETQLES-LRQREAEFSSAGHSLqdKQSVEETSGEGPEVEMESWQKQYDSLQKIVEKQQQKMDQLRSQVQSLEQ 629
Cdd:TIGR04523 526 IEKLESEKKEKESkISDLEDELNKDDFEL--KKENLEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIK 603

                         250
                  ....*....|....*
gi 966915597  630 EVAQEEGTSQALREE 644
Cdd:TIGR04523 604 EIEEKEKKISSLEKE 618

PTZ00121

MAEBL; Provisional

361-649

2.37e-06

MAEBL; Provisional

Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 51.30 E-value: 2.37e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  361 EHLLKEKELlidKQRKHISQLEQKVRESElqvHSALLGRPAPfgdvcLLRLQELQRENTFLRAQFAQKTEALSREKIDLE 440
Cdd:PTZ00121 1549 DELKKAEEL---KKAEEKKKAEEAKKAEE---DKNMALRKAE-----EAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEE 1617

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  441 KKLSASEV-EVQLIRESLKVALQKHSEEVKKQEErVKGRDKHINNLKKKCQKESEQNREKQQRIETLEryladlptlEDH 519
Cdd:PTZ00121 1618 AKIKAEELkKAEEEKKKVEQLKKKEAEEKKKAEE-LKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAE---------EDE 1687

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  520 QKQSQQLKdselKSTELQEKVTELESLLEEtqaicrdRETQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVEMESW 599
Cdd:PTZ00121 1688 KKAAEALK----KEAEEAKKAEELKKKEAE-------EKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEK 1756

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 966915597  600 QKqydsLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRD 649
Cdd:PTZ00121 1757 KK----IAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKIKD 1802

PTZ00121

MAEBL; Provisional

410-661

2.37e-06

MAEBL; Provisional

Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 51.30 E-value: 2.37e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  410 RLQELQRENTFLRAQFAQKTEAlsREKIDLEKKLSasevEVQLIRESLKVALQKHSEEVKKQEERVKGRDKHINN--LKK 487
Cdd:PTZ00121 1183 KAEEVRKAEELRKAEDARKAEA--ARKAEEERKAE----EARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERNNeeIRK 1256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  488 KCQKESEQNREKQQRIETLERYLADlptleDHQKQSQQLKDSELKSTELQEKVTELESLLEETQaicrdretQLESLRQR 567
Cdd:PTZ00121 1257 FEEARMAHFARRQAAIKAEEARKAD-----ELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAK--------KADEAKKK 1323

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  568 EAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQKQYDSLQKIVEKQQQKMDQLRSQVQSLEQEvAQEEGTSQALREEAQR 647
Cdd:PTZ00121 1324 AEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKK-AEEKKKADEAKKKAEE 1402

                         250
                  ....*....|....
gi 966915597  648 RDSALQQLRTAVKE 661
Cdd:PTZ00121 1403 DKKKADELKKAAAA 1416

PTZ00121

MAEBL; Provisional

422-684

3.27e-06

MAEBL; Provisional

Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 50.91 E-value: 3.27e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  422 RAQFAQKTEALSR--EKIDLEKKLSASEV----EVQLIRESLKVALQKHSEEVKKQEERVKGRDKHINNLKKKCQKESEQ 495
Cdd:PTZ00121 1517 KAEEAKKADEAKKaeEAKKADEAKKAEEKkkadELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEE 1596

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  496 -----NREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKSTELQEKVTELESLLEETQaicrDRETQLESLRQREAE 570
Cdd:PTZ00121 1597 vmklyEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEE----ENKIKAAEEAKKAEE 1672

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  571 FSSAGHSLQDKQSVEETSGEGPEVEMESwQKQYDSLQKIVEKQQQKMDQLRS-------QVQSLEQEVAQEEGTSQALRE 643
Cdd:PTZ00121 1673 DKKKAEEAKKAEEDEKKAAEALKKEAEE-AKKAEELKKKEAEEKKKAEELKKaeeenkiKAEEAKKEAEEDKKKAEEAKK 1751

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 966915597  644 EAQRRDSALQQLRTAVK---ELSVQNQDLIEKNLTLQEHLRQAQ 684
Cdd:PTZ00121 1752 DEEEKKKIAHLKKEEEKkaeEIRKEKEAVIEEELDEEDEKRRME 1795

COG4913

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];

528-683

3.42e-06

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];

Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 50.68 E-value: 3.42e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  528 DSELKSTELQEKVTELESLLEETQAICRDRETQLESLRQREAEFssaghslqdkQSVEETSGEgpEVEMESWQKQYDSLQ 607
Cdd:COG4913   607 DNRAKLAALEAELAELEEELAEAEERLEALEAELDALQERREAL----------QRLAEYSWD--EIDVASAEREIAELE 674

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  608 ---KIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDLIEK-----NLTLQEH 679
Cdd:COG4913   675 aelERLDASSDDLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLarlelRALLEER 754


                  ....
gi 966915597  680 LRQA 683
Cdd:COG4913   755 FAAA 758

Myosin_tail_1

pfam01576

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...

411-649

4.62e-06

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.

Pssm-ID: 460256 [Multi-domain] Cd Length: 1081 Bit Score: 50.56 E-value: 4.62e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   411 LQELQRENTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEevkkQEERVKGRDKHINNLKKKCq 490
Cdd:pfam01576  347 LQEMRQKHTQALEELTEQLEQAKRNKANLEKAKQALESENAELQAELRTLQQAKQD----SEHKRKKLEGQLQELQARL- 421

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   491 keSEQNREKQQRIETLERYLADLPTLedhqkqSQQLKDSELKSTELQEKVTELESLLEETQAICRDRETQLESLRQREAE 570
Cdd:pfam01576  422 --SESERQRAELAEKLSKLQSELESV------SSLLNEAEGKNIKLSKDVSSLESQLQDTQELLQEETRQKLNLSTRLRQ 493

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966915597   571 FSSAGHSLQDKQSVEETSGEGPEVEMESWQKQYDSLQKIVEKQQQKMDQLRSQVQSLEQEVaqeEGTSQALREEAQRRD 649
Cdd:pfam01576  494 LEDERNSLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKKLEEDAGTLEALEEGKKRLQREL---EALTQQLEEKAAAYD 569

sbcc

TIGR00618

exonuclease SbcC; All proteins in this family for which functions are known are part of an ...

412-770

6.75e-06

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]

Pssm-ID: 129705 [Multi-domain] Cd Length: 1042 Bit Score: 49.97 E-value: 6.75e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   412 QELQRENTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKH---SEEVKKQEERVKgRDKHINNLKKK 488
Cdd:TIGR00618  190 KSLHGKAELLTLRSQLLTLCTPCMPDTYHERKQVLEKELKHLREALQQTQQSHaylTQKREAQEEQLK-KQQLLKQLRAR 268

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   489 CQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKSTELQEKVTELESLLEETQAicrdretqlesLRQRE 568
Cdd:TIGR00618  269 IEELRAQEAVLEETQERINRARKAAPLAAHIKAVTQIEQQAQRIHTELQSKMRSRAKLLMKRAA-----------HVKQQ 337

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   569 AEFSSAGHSLQDKQSVEETSGEGPEVEMeSWQKQYD---SLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEA 645
Cdd:TIGR00618  338 SSIEEQRRLLQTLHSQEIHIRDAHEVAT-SIREISCqqhTLTQHIHTLQQQKTTLTQKLQSLCKELDILQREQATIDTRT 416

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   646 QRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQPGSPPSPDTAQLALELYQELASCLQDLQAVCSI---VTQRA 722
Cdd:TIGR00618  417 SAFRDLQGQLAHAKKQQELQQRYAELCAAAITCTAQCEKLEKIHLQESAQSLKEREQQLQTKEQIHLQETRKkavVLARL 496

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|..
gi 966915597   723 QGHDPNLSLLLG--IHSQHPETQLDLQKPDV--IKRKLEEVQQLRRDIEDLR 770
Cdd:TIGR00618  497 LELQEEPCPLCGscIHPNPARQDIDNPGPLTrrMQRGEQTYAQLETSEEDVY 548

COG4913

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];

410-567

7.53e-06

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];

Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 49.53 E-value: 7.53e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  410 RLQELQRENTFLRAQFAQKTEALSREKID-LEKKLSASEVEVQLIRESLKvALQKHSEEVKKQEERVKGRDkhINNLKKK 488
Cdd:COG4913   270 RLAELEYLRAALRLWFAQRRLELLEAELEeLRAELARLEAELERLEARLD-ALREELDELEAQIRGNGGDR--LEQLERE 346

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  489 CQKESEQNREKQQRIETLERYLADL--------PTLEDHQKQSQQLKDS-ELKSTELQEKVTELESLLEETQAICRDRET 559
Cdd:COG4913   347 IERLERELEERERRRARLEALLAALglplpasaEEFAALRAEAAALLEAlEEELEALEEALAEAEAALRDLRRELRELEA 426


                  ....*...
gi 966915597  560 QLESLRQR 567
Cdd:COG4913   427 EIASLERR 434

PRK02224

DNA double-strand break repair Rad50 ATPase;

421-678

8.11e-06

DNA double-strand break repair Rad50 ATPase;

Pssm-ID: 179385 [Multi-domain] Cd Length: 880 Bit Score: 49.65 E-value: 8.11e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 421 LRAQFAQKTEALSREKI-DLEKKLSASEVEVQLI----------RESLKVALQKHSEevKKQE-ERVKGRDKHINNLKKK 488
Cdd:PRK02224 192 LKAQIEEKEEKDLHERLnGLESELAELDEEIERYeeqreqaretRDEADEVLEEHEE--RREElETLEAEIEDLRETIAE 269

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 489 CQKE----SEQNREKQQRIETLERYLADLptLEDHQKQSQQLKDSELKSTELQEKVTELESLLEETQAICRDRETQLESL 564
Cdd:PRK02224 270 TEREreelAEEVRDLRERLEELEEERDDL--LAEAGLDDADAEAVEARREELEDRDEELRDRLEECRVAAQAHNEEAESL 347

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 565 RQREAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQKQYDSLQKivekqqqKMDQLRSQVQSLEQEVAQEEGTSQALREE 644
Cdd:PRK02224 348 REDADDLEERAEELREEAAELESELEEAREAVEDRREEIEELEE-------EIEELRERFGDAPVDLGNAEDFLEELREE 420

                        250       260       270
                 ....*....|....*....|....*....|....
gi 966915597 645 AQRRDSALQQLRTAVKELsvqnQDLIEKNLTLQE 678
Cdd:PRK02224 421 RDELREREAELEATLRTA----RERVEEAEALLE 450

PTZ00121

MAEBL; Provisional

410-661

8.82e-06

MAEBL; Provisional

Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 49.75 E-value: 8.82e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  410 RLQELQRENTFLRAQFAQKTEALSREKIDLEKKlsASEV----EVQLIRESLKVALQKHSEEVKKQEERVKGRDKHINNL 485
Cdd:PTZ00121 1491 KAEEAKKKADEAKKAAEAKKKADEAKKAEEAKK--ADEAkkaeEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEE 1568

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  486 KKKCQKESEQNREKQQRIETLERylADLPTLEDHQKQSQQLKDSEL-KSTELQEKVTELESLLEETQAICRDRETQLESL 564
Cdd:PTZ00121 1569 AKKAEEDKNMALRKAEEAKKAEE--ARIEEVMKLYEEEKKMKAEEAkKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEK 1646

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  565 RQ----REAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQKqydslqKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQA 640
Cdd:PTZ00121 1647 KKaeelKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDE------KKAAEALKKEAEEAKKAEELKKKEAEEKKKAEE 1720

                         250       260
                  ....*....|....*....|.
gi 966915597  641 LREEAQRRDSALQQLRTAVKE 661
Cdd:PTZ00121 1721 LKKAEEENKIKAEEAKKEAEE 1741

mukB

chromosome partition protein MukB;

432-722

1.02e-05

chromosome partition protein MukB;

Pssm-ID: 235316 [Multi-domain] Cd Length: 1486 Bit Score: 49.19 E-value: 1.02e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  432 LSREKIDLEKKLSASEVEVQLIRESLkvalqkhsEEVKKQEERVKGRDKHInnlkkkcQKESEQNREKQQRI-------E 504
Cdd:PRK04863  284 HLEEALELRRELYTSRRQLAAEQYRL--------VEMARELAELNEAESDL-------EQDYQAASDHLNLVqtalrqqE 348

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  505 TLERYLADLPTLEDhqkqsqQLKDSELKSTELQEKVTELESLLEETQAICRDRETQLESLRQR-EAEFSSAGHSLQDKQS 583
Cdd:PRK04863  349 KIERYQADLEELEE------RLEEQNEVVEEADEQQEENEARAEAAEEEVDELKSQLADYQQAlDVQQTRAIQYQQAVQA 422

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  584 VEETSG---------EGPEVEMESWQKQYDSLQKIVEKQQQKMDQ--------------LRSQVQSLEQEVAQEEGTSQA 640
Cdd:PRK04863  423 LERAKQlcglpdltaDNAEDWLEEFQAKEQEATEELLSLEQKLSVaqaahsqfeqayqlVRKIAGEVSRSEAWDVARELL 502

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  641 LREEAQR-RDSALQQLRTAVKELSvqnQDLIEKNlTLQEHLRQAQPGSPPSPDTAQLALELYQELASCLQDLQAVCSIVT 719
Cdd:PRK04863  503 RRLREQRhLAEQLQQLRMRLSELE---QRLRQQQ-RAERLLAEFCKRLGKNLDDEDELEQLQEELEARLESLSESVSEAR 578


                  ...
gi 966915597  720 QRA 722
Cdd:PRK04863  579 ERR 581

PRK02224

DNA double-strand break repair Rad50 ATPase;

410-680

1.15e-05

DNA double-strand break repair Rad50 ATPase;

Pssm-ID: 179385 [Multi-domain] Cd Length: 880 Bit Score: 48.88 E-value: 1.15e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 410 RLQELQRENTFLRAQFAqkTEALSREKIDLEKK-LSASEVEVQLIRESLKVALQKHS-------EEVKKQEERVKGRDKH 481
Cdd:PRK02224 287 RLEELEEERDDLLAEAG--LDDADAEAVEARREeLEDRDEELRDRLEECRVAAQAHNeeaeslrEDADDLEERAEELREE 364

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 482 INNLKKKCQKESEQNREKQQRIETLERYLADLptledhqkqSQQLKDSELKSTELQEKVTELESLLEETQAICRDRETQL 561
Cdd:PRK02224 365 AAELESELEEAREAVEDRREEIEELEEEIEEL---------RERFGDAPVDLGNAEDFLEELREERDELREREAELEATL 435

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 562 ESLRQREAE---FSSAGHSLQDKQSVEETSG-----------EGPEVEMESWQKQYDSLQKIVE------KQQQKMDQLR 621
Cdd:PRK02224 436 RTARERVEEaeaLLEAGKCPECGQPVEGSPHvetieedrervEELEAELEDLEEEVEEVEERLEraedlvEAEDRIERLE 515

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966915597 622 SQVQSLEQEVAQEEGT-------SQALREEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHL 680
Cdd:PRK02224 516 ERREDLEELIAERRETieekrerAEELRERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKL 581

EnvC

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...

593-779

1.34e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];

Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 48.22 E-value: 1.34e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 593 EVEMESWQKQYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVKELsvqNQDLIEK 672
Cdd:COG4942   26 EAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAEL---RAELEAQ 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 673 NLTLQEHLRQAQPGSPPSPDTAQLALELYQELASCLQDLQAVcsivtqraqghdpnlslllgihsqhpeTQLDLQKPDVI 752
Cdd:COG4942  103 KEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYL---------------------------APARREQAEEL 155

                        170       180
                 ....*....|....*....|....*..
gi 966915597 753 KRKLEEVQQLRRDIEDLRTTMSDRYAQ 779
Cdd:COG4942  156 RADLAELAALRAELEAERAELEALLAE 182

YhaN

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];

485-684

1.95e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];

Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 48.23 E-value: 1.95e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 485 LKKKCQKESEQNREKQQRIETLerylaDLPTLEDHQKQSQQLKDSELKSTELQEKVTELESLLEETQAICRDRETQLESL 564
Cdd:COG4717   47 LLERLEKEADELFKPQGRKPEL-----NLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKL 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 565 RQREAefssAGHSLQDKQSVEEtsgegpevEMESWQKQYDSLqkivEKQQQKMDQLRSQVQSLEQEVAQ-EEGTSQALRE 643
Cdd:COG4717  122 EKLLQ----LLPLYQELEALEA--------ELAELPERLEEL----EERLEELRELEEELEELEAELAElQEELEELLEQ 185

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 966915597 644 EAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQ 684
Cdd:COG4717  186 LSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELE 226

YhaN

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];

357-713

2.54e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];

Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 47.84 E-value: 2.54e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 357 LNSNEHLLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTFLRAQFAQKTEALSREK 436
Cdd:COG4717  104 LEELEAELEELREELEKLEKLLQLLPLYQELEALEAELAELPERLEELEERLEELRELEEELEELEAELAELQEELEELL 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 437 IDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRDKHINNLKKKCQKESEQNREKQQR-------------- 502
Cdd:COG4717  184 EQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEARlllliaaallallg 263

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 503 ----IETLERYLADLPTL----------------EDHQKQSQQLKD----SELKSTELQEKVTELESLLEETQAICRDRE 558
Cdd:COG4717  264 lggsLLSLILTIAGVLFLvlgllallflllarekASLGKEAEELQAlpalEELEEEELEELLAALGLPPDLSPEELLELL 343

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 559 TQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVEMESwqkqYDSLQKIVEKQQQKmDQLRSQVQSLEQEVAQEEGTS 638
Cdd:COG4717  344 DRIEELQELLREAEELEEELQLEELEQEIAALLAEAGVED----EEELRAALEQAEEY-QELKEELEELEEQLEELLGEL 418

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966915597 639 QALREEAQRRD--SALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQpgsppspdTAQLALELYQELASCLQDLQA 713
Cdd:COG4717  419 EELLEALDEEEleEELEELEEELEELEEELEELREELAELEAELEQLE--------EDGELAELLQELEELKAELRE 487

GumC

COG3206

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];

412-639

2.74e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 442439 [Multi-domain] Cd Length: 687 Bit Score: 47.70 E-value: 2.74e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 412 QELQRENTFLRAQFAQKT-EALSREKIDLEKKLSASEVEVQLIRESLKVAlqkhseevkKQEERVKGRDKHINNLKKKCQ 490
Cdd:COG3206  159 EAYLEQNLELRREEARKAlEFLEEQLPELRKELEEAEAALEEFRQKNGLV---------DLSEEAKLLLQQLSELESQLA 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 491 KESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKD------------SELKST---------ELQEKVTELESLL-E 548
Cdd:COG3206  230 EARAELAEAEARLAALRAQLGSGPDALPELLQSPVIQQlraqlaeleaelAELSARytpnhpdviALRAQIAALRAQLqQ 309

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 549 ETQAICRDRETQLESLRQREAEFSsaghslQDKQSVEETSGEGPEVemeswQKQYDSLQKIVEKQQQKMDQLRSQVQSLE 628
Cdd:COG3206  310 EAQRILASLEAELEALQAREASLQ------AQLAQLEARLAELPEL-----EAELRRLEREVEVARELYESLLQRLEEAR 378

                        250
                 ....*....|.
gi 966915597 629 QEVAQEEGTSQ 639
Cdd:COG3206  379 LAEALTVGNVR 389

mukB

chromosome partition protein MukB;

497-707

2.76e-05

chromosome partition protein MukB;

Pssm-ID: 235316 [Multi-domain] Cd Length: 1486 Bit Score: 48.03 E-value: 2.76e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  497 REKQQRIETLERYLADLPtlEDHQKQSQQLKDSELKSTELQEKVTELESLLEET-QAICRDRETQLESLRQREAEFSSAG 575
Cdd:PRK04863  840 RQLNRRRVELERALADHE--SQEQQQRSQLEQAKEGLSALNRLLPRLNLLADETlADRVEEIREQLDEAEEAKRFVQQHG 917

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  576 HSLQDKQSVEETSGEGPEvEMESWQKQYDSLQKIVEKQQQKMDQLRSQVQ------------SLEQEVAQEEGTSQALRE 643
Cdd:PRK04863  918 NALAQLEPIVSVLQSDPE-QFEQLKQDYQQAQQTQRDAKQQAFALTEVVQrrahfsyedaaeMLAKNSDLNEKLRQRLEQ 996

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966915597  644 EAQRRDSALQQLRTAVKELSVQNQDLIE-------KNLTLQEHLRQAQPGSPPSPDTAQLAL-----ELYQELASC 707
Cdd:PRK04863  997 AEQERTRAREQLRQAQAQLAQYNQVLASlkssydaKRQMLQELKQELQDLGVPADSGAEERArarrdELHARLSAN 1072

SCP-1

pfam05483

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...

328-671

3.03e-05

Pssm-ID: 114219 [Multi-domain] Cd Length: 787 Bit Score: 47.79 E-value: 3.03e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  328 QLQNGAICHHPAAFAPSlpILEPAQWISILNSNehLLKEKELLidKQRKHISQLEQKVRESELQVHSALL--GRPApfgd 405
Cdd:pfam05483  52 QVANSGDCHYQEGLKDS--DFENSEGLSRLYSK--LYKEAEKI--KKWKVSIEAELKQKENKLQENRKIIeaQRKA---- 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  406 vcllrLQELQRENTflraQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSE-EVKKQEERVKGRDKHINN 484
Cdd:pfam05483 122 -----IQELQFENE----KVSLKLEEEIQENKDLIKENNATRHLCNLLKETCARSAEKTKKyEYEREETRQVYMDLNNNI 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  485 LKKKCQKESEQNREKQQRIETLERYLADLPTLED-HQKQSQQLKDSE-------LKSTELQEKVTELESLLEETqaicRD 556
Cdd:pfam05483 193 EKMILAFEELRVQAENARLEMHFKLKEDHEKIQHlEEEYKKEINDKEkqvslllIQITEKENKMKDLTFLLEES----RD 268

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  557 RETQL--------ESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQKQYDSLQKIVEKQQQKMDQLRSQVQSLE 628
Cdd:pfam05483 269 KANQLeektklqdENLKELIEKKDHLTKELEDIKMSLQRSMSTQKALEEDLQIATKTICQLTEEKEAQMEELNKAKAAHS 348

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 966915597  629 QEVAQEEGTS----QALREEAQRRDSALQQLRTAVKELSVQNQDLIE 671
Cdd:pfam05483 349 FVVTEFEATTcsleELLRTEQQRLEKNEDQLKIITMELQKKSSELEE 395

CCDC158

pfam15921

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...

317-661

3.05e-05

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.

Pssm-ID: 464943 [Multi-domain] Cd Length: 1112 Bit Score: 47.81 E-value: 3.05e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   317 LELIRLQMEQMQLQNGAicHHPAAFAPslpILEPAQWISILNSNEHLLKEKELLIDKQRKHISQLEQKVRESELQ----- 391
Cdd:pfam15921  564 IEILRQQIENMTQLVGQ--HGRTAGAM---QVEKAQLEKEINDRRLELQEFKILKDKKDAKIRELEARVSDLELEkvklv 638

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   392 ---------VHSALLGRPAPFGDV--CLLRLQELQRENTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVA 460
Cdd:pfam15921  639 nagserlraVKDIKQERDQLLNEVktSRNELNSLSEDYEVLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKSM 718

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   461 LQKHSEEVK---KQEERVKGRDKHINNLKKKCQKESE----QNREKQQRIETLERYLADLPTL-EDHQKQSQQLKDSELK 532
Cdd:pfam15921  719 EGSDGHAMKvamGMQKQITAKRGQIDALQSKIQFLEEamtnANKEKHFLKEEKNKLSQELSTVaTEKNKMAGELEVLRSQ 798

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   533 STELQEKVTELESLLEETQ---AICRDretqlesLRQREaEFSSAGHSLQDKQSVEETSGEGpevemeswqkqYDSLQKI 609
Cdd:pfam15921  799 ERRLKEKVANMEVALDKASlqfAECQD-------IIQRQ-EQESVRLKLQHTLDVKELQGPG-----------YTSNSSM 859

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 966915597   610 VEKQQQKMDQLRSQ-----VQSLEQEVAQEEGTSQALREEAQRR-DSALQQLRTAVKE 661
Cdd:pfam15921  860 KPRLLQPASFTRTHsnvpsSQSTASFLSHHSRKTNALKEDPTRDlKQLLQELRSVINE 917

PTZ00121

MAEBL; Provisional

422-661

3.14e-05

MAEBL; Provisional

Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 47.83 E-value: 3.14e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  422 RAQFAQKTEALSREKidlEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRDKHinnlKKKCQ--KESEQNREK 499
Cdd:PTZ00121 1452 KAEEAKKAEEAKKKA---EEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEA----KKKADeaKKAEEAKKA 1524

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  500 QQRIETLERYLAD-LPTLEDHQKQSQQLKDSELKSTELQEKVTELESLLEETQAICRDRET--QLESLRQREAEF---SS 573
Cdd:PTZ00121 1525 DEAKKAEEAKKADeAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEakKAEEARIEEVMKlyeEE 1604

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  574 AGHSLQDKQSVEETSGEGPEV-EMESWQKQYDSLQKIVEKQQQKMDQLR-----SQVQSLEQEVAQEEGTSQA--LREEA 645
Cdd:PTZ00121 1605 KKMKAEEAKKAEEAKIKAEELkKAEEEKKKVEQLKKKEAEEKKKAEELKkaeeeNKIKAAEEAKKAEEDKKKAeeAKKAE 1684

                         250
                  ....*....|....*.
gi 966915597  646 QRRDSALQQLRTAVKE 661
Cdd:PTZ00121 1685 EDEKKAAEALKKEAEE 1700

CCDC158

pfam15921

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...

364-783

3.78e-05

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.

Pssm-ID: 464943 [Multi-domain] Cd Length: 1112 Bit Score: 47.42 E-value: 3.78e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   364 LKEKELLIDKQRKHISQLEQKVRESE--LQVHSALLGRPAPFGDVCLLRLQELQRENTFLRaQFAQKTEALsreKIDLEK 441
Cdd:pfam15921  484 LTAKKMTLESSERTVSDLTASLQEKEraIEATNAEITKLRSRVDLKLQELQHLKNEGDHLR-NVQTECEAL---KLQMAE 559

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   442 KLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKgRDKHINNLKKKCQKESEQNREKQQRIETLERYLADL-----PTL 516
Cdd:pfam15921  560 KDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQ-LEKEINDRRLELQEFKILKDKKDAKIRELEARVSDLelekvKLV 638

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   517 EDHQKQSQQLKDSELKSTELQEKV----TELESLLEETQAICRDRETQLESLR----QREAEFSSAGHSLQDK----QSV 584
Cdd:pfam15921  639 NAGSERLRAVKDIKQERDQLLNEVktsrNELNSLSEDYEVLKRNFRNKSEEMEtttnKLKMQLKSAQSELEQTrntlKSM 718

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   585 EETSGEGPEVEMeswqkqydSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRTA----VK 660
Cdd:pfam15921  719 EGSDGHAMKVAM--------GMQKQITAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKNKLSQELSTVATEknkmAG 790

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   661 ELSV---QNQDLIEKNLTLQEHLRQAQPGSPPSPDTAQlalelYQELASCLQDLQAVCSIVTQRAQGHDPNLSL------ 731
Cdd:pfam15921  791 ELEVlrsQERRLKEKVANMEVALDKASLQFAECQDIIQ-----RQEQESVRLKLQHTLDVKELQGPGYTSNSSMkprllq 865

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966915597   732 ---LLGIHSQHPETQLDL-------QKPDVIKRklEEVQQLRRDIEDLRTTMSDRYAQDMGE 783
Cdd:pfam15921  866 pasFTRTHSNVPSSQSTAsflshhsRKTNALKE--DPTRDLKQLLQELRSVINEEPTVQLSK 925

Myosin_tail_1

pfam01576

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...

355-684

4.84e-05

Pssm-ID: 460256 [Multi-domain] Cd Length: 1081 Bit Score: 47.09 E-value: 4.84e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   355 SILNSNEHLLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQ--ELQRENTFLRAQFAQKTEAL 432
Cdd:pfam01576  166 SNLAEEEEKAKSLSKLKNKHEAMISDLEERLKKEEKGRQELEKAKRKLEGESTDLQEQiaELQAQIAELRAQLAKKEEEL 245

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   433 SREKIDLEKKLSASEVEVQLIREslkvaLQKHSEEVKKQEERVKGRDkhinnlkkkcQKESEQNREKQQRIETLERYLAD 512
Cdd:pfam01576  246 QAALARLEEETAQKNNALKKIRE-----LEAQISELQEDLESERAAR----------NKAEKQRRDLGEELEALKTELED 310

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   513 lpTLEDHQKQSqqlkdsELKSTELQEkVTELESLLEETQaicRDRETQLESLRQREaefSSAGHSLQD--------KQSV 584
Cdd:pfam01576  311 --TLDTTAAQQ------ELRSKREQE-VTELKKALEEET---RSHEAQLQEMRQKH---TQALEELTEqleqakrnKANL 375

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   585 EETSgEGPEVEMESWQKQYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVKELSV 664
Cdd:pfam01576  376 EKAK-QALESENAELQAELRTLQQAKQDSEHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEG 454

                          330       340
                   ....*....|....*....|
gi 966915597   665 QNQDLIEKNLTLQEHLRQAQ 684
Cdd:pfam01576  455 KNIKLSKDVSSLESQLQDTQ 474

DR0291

COG1579

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...

501-686

4.90e-05

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];

Pssm-ID: 441187 [Multi-domain] Cd Length: 236 Bit Score: 45.69 E-value: 4.90e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 501 QRIETLERYLADLPtledhqkqsQQLKDSELKSTELQEKVTELESLLEETQAICRDRETQLESLRQREAEFSSAGHSLQD 580
Cdd:COG1579   17 SELDRLEHRLKELP---------AELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVRN 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 581 kqsveetsgegpevemeswQKQYDSLQKIVEKQQQKMDQLRS-------QVQSLEQEVAQEEG----TSQALREEAQRRD 649
Cdd:COG1579   88 -------------------NKEYEALQKEIESLKRRISDLEDeilelmeRIEELEEELAELEAelaeLEAELEEKKAELD 148

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 966915597 650 SALQQLRTAVKELSVQNQDLIEK----NLTLQEHLRQAQPG 686
Cdd:COG1579  149 EELAELEAELEELEAEREELAAKippeLLALYERIRKRKNG 189

PTZ00121

MAEBL; Provisional

410-660

5.78e-05

MAEBL; Provisional

Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 47.06 E-value: 5.78e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  410 RLQELQRENTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRDKhinnlKKKC 489
Cdd:PTZ00121 1243 KKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEE-----AKKA 1317

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  490 QKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKSTELQEKVTELESLLEETQAicrdretqlESLRQREA 569
Cdd:PTZ00121 1318 DEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKA---------DAAKKKAE 1388

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  570 EFSSAGHSlqdKQSVEETSGEGPEV-EMESWQKQYDSLQKIVEkQQQKMDQLRSQVqslEQEVAQEEGTSQAlrEEAQRR 648
Cdd:PTZ00121 1389 EKKKADEA---KKKAEEDKKKADELkKAAAAKKKADEAKKKAE-EKKKADEAKKKA---EEAKKADEAKKKA--EEAKKA 1459

                         250
                  ....*....|..
gi 966915597  649 DSALQQLRTAVK 660
Cdd:PTZ00121 1460 EEAKKKAEEAKK 1471

mukB

chromosome partition protein MukB;

423-697

7.34e-05

chromosome partition protein MukB;

Pssm-ID: 235316 [Multi-domain] Cd Length: 1486 Bit Score: 46.49 E-value: 7.34e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  423 AQFAQKTEALSREKIDLEKKLSAS-------EVEVQLIR------------ESLKVALQKHSEEvKKQEERVKGRDKHIN 483
Cdd:PRK04863  445 EEFQAKEQEATEELLSLEQKLSVAqaahsqfEQAYQLVRkiagevsrseawDVARELLRRLREQ-RHLAEQLQQLRMRLS 523

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  484 NLkkkcqkesEQNREKQQRietLERYLADLptledHQKQSQQLKDSElkstelqekvtELESLLEETQAICRDRETQLES 563
Cdd:PRK04863  524 EL--------EQRLRQQQR---AERLLAEF-----CKRLGKNLDDED-----------ELEQLQEELEARLESLSESVSE 576

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  564 LRQREAEfssaghslqdkqsveetsgegpeveMESWQKQYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALre 643
Cdd:PRK04863  577 ARERRMA-------------------------LRQQLEQLQARIQRLAARAPAWLAAQDALARLREQSGEEFEDSQDV-- 629

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 966915597  644 eaqrrDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQ-AQPGSPPSPDTAQLA 697
Cdd:PRK04863  630 -----TEYMQQLLERERELTVERDELAARKQALDEEIERlSQPGGSEDPRLNALA 679

ALIX_LYPXL_bnd

pfam13949

ALIX V-shaped domain binding to HIV; The binding of the LYPxL motif of late HIV p6Gag and EIAV ...

533-661

1.06e-04

ALIX V-shaped domain binding to HIV; The binding of the LYPxL motif of late HIV p6Gag and EIAV p9Gag to this domain is necessary for viral budding.This domain is generally central between an N-terminal Bro1 domain, pfam03097 and a C-terminal proline-rich domain. The retroviruses thus used this domain to hijack the ESCRT system of the cell.

Pssm-ID: 464053 [Multi-domain] Cd Length: 294 Bit Score: 44.92 E-value: 1.06e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  533 STELQEKVTELESLLEETQAICRDRETQLESLRQREAEFSSAGHSLQDKQSVEETSGEgpEVEMESWQKQYDSLQKIVEK 612
Cdd:pfam13949 132 SPSVEEQVAKLRELLNKLNELKREREQLLKDLKEKARNDDISPKLLLEKARLIAPNQE--EQLFEEELEKYDPLQNRLEQ 209

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 966915597  613 QQQKMDQLRSQVQSLEQEVAQEegtSQALREEAQRRDSALQQLRTAVKE 661
Cdd:pfam13949 210 NLHKQEELLKEITEANNEFLQD---KRVDSEKQRQREEALQKLENAYDK 255

V_Alix_like

cd08915

Protein-interacting V-domain of mammalian Alix and related domains; This superfamily contains ...

376-679

1.25e-04

Pssm-ID: 185746 [Multi-domain] Cd Length: 342 Bit Score: 45.03 E-value: 1.25e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 376 KHISQLEQKVRESELQVHSALLGRPAPFgDVCLLRLQELQRENTFLRAQFAQKTEALsREKIDLEKKLSASEVEVQLIRE 455
Cdd:cd08915   45 ASIDDLQKPENLPDSIQHSQEIIEEGGL-DNIEQSFKELSKLRQNVEELLQECEELL-EEEAAEDDQLRAKFGTLRWRRP 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 456 SLKVALQKHSEEVkkqeervkgrdkhiNNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELkSTE 535
Cdd:cd08915  123 SSDEAAKELYEKV--------------TKLRGYLEQASNSDNEVLQCYESIDPNLVLLCGGYKELKAFIPSPYPAL-DPE 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 536 LQEKVTELESLLEETQAICRDRETQLESLRQREAEFSSAghslqdkQSVEETSGEGPEVEMES-WQKQ---YDSLQKIVE 611
Cdd:cd08915  188 VSEVVSSLRPLLNEVSELEKERERFISELEIKSRNNDIL-------PKLITEYKKNGTTEFEDlFEEHlkkFDKDLTYVE 260

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966915597 612 KQQQKMDQLRSQVQSLEQEVAQEEGTSqalrEEAQRRDSALQQLRTAVKELS--VQN--------QDLIEKNLTLQEH 679
Cdd:cd08915  261 KTKKKQIELIKEIDAANQEFSQVKNSN----DSLDPREEALQDLEASYKKYLelKENlnegskfyNDLIEKVNRLLEE 334

ClyA_Cry6Aa-like

cd22656

Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes ...

511-699

1.43e-04

Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes pesticidal Cry6Aa toxin from Bacillus thuringiensis, one of the many parasporal crystal (Cry) toxins produced during the sporulation phase of growth. Many of these proteins are toxic to numerous insect species and have been effectively used as proteinaceous insecticides to directly kill insect pests; some have been used to control insect growth on transgenic agricultural plants. Cry6Aa exists as a protoxin, which is activated by cleavage using trypsin. Structure studies for Cry6Aa support a mechanism of action by pore formation, similar to cytolysin A (ClyA)-type alpha pore-forming toxins (alpha-PFTs) such as HblB, and bioassay and mutation studies show that Cry6Aa is an active pore-forming toxin. Cry6Aa shows atypical features compared to other members of alpha-PFTs, including internal repeat sequences and small loop regions within major alpha helices.

Pssm-ID: 439154 [Multi-domain] Cd Length: 309 Bit Score: 44.67 E-value: 1.43e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 511 ADLPTLEDHQKQSQQLKDSELKS-TELQEKVTELESLLEETQAICRDRETQLESLRQReaefssaghsLQDKqsVEETSG 589
Cdd:cd22656  107 TDDEELEEAKKTIKALLDDLLKEaKKYQDKAAKVVDKLTDFENQTEKDQTALETLEKA----------LKDL--LTDEGG 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 590 EGPEVEMESWQKQYDSLQK-IVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVKEL-SVQNQ 667
Cdd:cd22656  175 AIARKEIKDLQKELEKLNEeYAAKLKAKIDELKALIADDEAKLAAALRLIADLTAADTDLDNLLALIGPAIPALeKLQGA 254

                        170       180       190
                 ....*....|....*....|....*....|....
gi 966915597 668 -DLIEKNL-TLQEHLRQAqPGSPPSPDTAQLALE 699
Cdd:cd22656  255 wQAIATDLdSLKDLLEDD-ISKIPAAILAKLELE 287

SPEC

cd00176

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...

494-671

1.60e-04

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here

Pssm-ID: 238103 [Multi-domain] Cd Length: 213 Bit Score: 43.59 E-value: 1.60e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 494 EQNREKQQRIETLERYLADL-PTLEDHQKQSQQLKDSE-LKSTELQEKVTELESLLEETQAICRDRETQLESLRQREAEF 571
Cdd:cd00176   33 ESVEALLKKHEALEAELAAHeERVEALNELGEQLIEEGhPDAEEIQERLEELNQRWEELRELAEERRQRLEEALDLQQFF 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 572 SSAGHSLQ---DKQSVEETSGEGPEVE-MESWQKQYDSLQKIVEKQQQKMDQLRSQVQSLEQEVaqeegtSQALREEAQR 647
Cdd:cd00176  113 RDADDLEQwleEKEAALASEDLGKDLEsVEELLKKHKELEEELEAHEPRLKSLNELAEELLEEG------HPDADEEIEE 186

                        170       180
                 ....*....|....*....|....
gi 966915597 648 RDSALQQLRTAVKELSVQNQDLIE 671
Cdd:cd00176  187 KLEELNERWEELLELAEERQKKLE 210

CCDC158

pfam15921

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...

376-664

1.60e-04

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.

Pssm-ID: 464943 [Multi-domain] Cd Length: 1112 Bit Score: 45.49 E-value: 1.60e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   376 KHISQLEQKVReselQVHSALLGRPAPFGDvcllRLQELQRENTFLRAQFAQ-KTE--ALSREKIDLEKKLSasEVEVQL 452
Cdd:pfam15921  317 RQLSDLESTVS----QLRSELREAKRMYED----KIEELEKQLVLANSELTEaRTErdQFSQESGNLDDQLQ--KLLADL 386

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   453 IRESLKVALQKhsEEVKKQEERVKGRDKHINNLKKkcqkESEQNREKQQRIETLERYLADlptlEDHQKQSQQLKDSELK 532
Cdd:pfam15921  387 HKREKELSLEK--EQNKRLWDRDTGNSITIDHLRR----ELDDRNMEVQRLEALLKAMKS----ECQGQMERQMAAIQGK 456

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   533 STELqEKVTELESLLEETQAICRDRETQLE----SLRQREAEFSSAGHSLQDKQ-SVEETSGE----------------- 590
Cdd:pfam15921  457 NESL-EKVSSLTAQLESTKEMLRKVVEELTakkmTLESSERTVSDLTASLQEKErAIEATNAEitklrsrvdlklqelqh 535

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966915597   591 --GPEVEMESWQKQYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVKELSV 664
Cdd:pfam15921  536 lkNEGDHLRNVQTECEALKLQMAEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRLELQEFKI 611

Cast

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...

478-672

1.67e-04

Pssm-ID: 431111 [Multi-domain] Cd Length: 766 Bit Score: 45.20 E-value: 1.67e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  478 RDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPT---------------LEDHQKQSQQLKdsELKSTELQEKVTE 542
Cdd:pfam10174 392 KERKINVLQKKIENLQEQLRDKDKQLAGLKERVKSLQTdssntdtalttleeaLSEKERIIERLK--EQREREDRERLEE 469

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  543 LESLLEETQaicrDRETQLESLRQREAEFSSAGHSLQDKQSVEETSG-------EGPEVEMESWQKQYDSLQKIVEKQQQ 615
Cdd:pfam10174 470 LESLKKENK----DLKEKVSALQPELTEKESSLIDLKEHASSLASSGlkkdsklKSLEIAVEQKKEECSKLENQLKKAHN 545

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966915597  616 KMDQLR------SQVQSLEQEVAQEegtsqalREEAQRRDSALQQLRTAVKELSVQNQDLIEK 672
Cdd:pfam10174 546 AEEAVRtnpeinDRIRLLEQEVARY-------KEESGKAQAEVERLLGILREVENEKNDKDKK 601

PRK02224

DNA double-strand break repair Rad50 ATPase;

410-663

1.69e-04

DNA double-strand break repair Rad50 ATPase;

Pssm-ID: 179385 [Multi-domain] Cd Length: 880 Bit Score: 45.42 E-value: 1.69e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 410 RLQELQREntflRAQFAQKTEALSrEKIDLEKKLSASEVEVQLIRESLKVA---LQKHSEEVKKQEERVKGRDKHINNLK 486
Cdd:PRK02224 476 RVEELEAE----LEDLEEEVEEVE-ERLERAEDLVEAEDRIERLEERREDLeelIAERRETIEEKRERAEELRERAAELE 550

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 487 KKCQKESEQNREKQQRIETLERYLADLptledhqkqsqqlkdselkSTELQEKVTELESL--LEETQAICRDRETQLESL 564
Cdd:PRK02224 551 AEAEEKREAAAEAEEEAEEAREEVAEL-------------------NSKLAELKERIESLerIRTLLAAIADAEDEIERL 611

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 565 RQREAEFSSAGHSLQDKQS-----VEETSGEGPEVEMESWQKQYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQ 639
Cdd:PRK02224 612 REKREALAELNDERRERLAekrerKRELEAEFDEARIEEAREDKERAEEYLEQVEEKLDELREERDDLQAEIGAVENELE 691

                        250       260       270
                 ....*....|....*....|....*....|
gi 966915597 640 ALREEAQRRDS------ALQQLRTAVKELS 663
Cdd:PRK02224 692 ELEELRERREAlenrveALEALYDEAEELE 721

COG2433

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];

430-566

1.87e-04

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];

Pssm-ID: 441980 [Multi-domain] Cd Length: 644 Bit Score: 44.85 E-value: 1.87e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 430 EALSREKidlEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRDKHINNLKkkcqkesEQNREKQQRIETLERY 509
Cdd:COG2433  380 EALEELI---EKELPEEEPEAEREKEHEERELTEEEEEIRRLEEQVERLEAEVEELE-------AELEEKDERIERLERE 449

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 966915597 510 LADLptleDHQKQSQQLKDSELKSteLQEKVTELESLLEETQAICRDRETQLESLRQ 566
Cdd:COG2433  450 LSEA----RSEERREIRKDREISR--LDREIERLERELEEERERIEELKRKLERLKE 500

CwlO1

COG3883

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...

435-654

2.05e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];

Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 44.44 E-value: 2.05e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 435 EKIDLEKKLSASEVEVQLIRESLKvALQKHSEEVKKQEERVKGRdkhINNLKKKCQKESEQNREKQQRIETLERYLADLp 514
Cdd:COG3883   17 QIQAKQKELSELQAELEAAQAELD-ALQAELEELNEEYNELQAE---LEALQAEIDKLQAEIAEAEAEIEERREELGER- 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 515 tLEDHQKQSQQLKDSE--LKSTELQEKVTELESLleeTQAICRDRETqLESLRQREAEFSSAGHSLQDKQSVEETSgegp 592
Cdd:COG3883   92 -ARALYRSGGSVSYLDvlLGSESFSDFLDRLSAL---SKIADADADL-LEELKADKAELEAKKAELEAKLAELEAL---- 162

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966915597 593 EVEMESWQKQydsLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQ 654
Cdd:COG3883  163 KAELEAAKAE---LEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAA 221

PRK11281

mechanosensitive channel MscK;

420-709

2.15e-04

mechanosensitive channel MscK;

Pssm-ID: 236892 [Multi-domain] Cd Length: 1113 Bit Score: 44.90 E-value: 2.15e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  420 FLRAQFAQK--TEALSREKIDLEKKLSASEVEVQLIRESLKVALqkhseEVKKQEERVKgrdKHINNLKKKCQKESEQNR 497
Cdd:PRK11281   26 FARAASNGDlpTEADVQAQLDALNKQKLLEAEDKLVQQDLEQTL-----ALLDKIDRQK---EETEQLKQQLAQAPAKLR 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  498 EKQQRIETLERYLADlPTLEDHQKQSQqlkdselksTELQEKVTELESLLEETQAICRDRETQLESLRQR----EAEFSS 573
Cdd:PRK11281   98 QAQAELEALKDDNDE-ETRETLSTLSL---------RQLESRLAQTLDQLQNAQNDLAEYNSQLVSLQTQperaQAALYA 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  574 AGHSLQDKQSVEETSGEGPEVEMESWQKQYDSLQKIVEKQ---QQKMDQLRSQVQSLEQevaqeegtsqalreeaQRRDs 650
Cdd:PRK11281  168 NSQRLQQIRNLLKGGKVGGKALRPSQRVLLQAEQALLNAQndlQRKSLEGNTQLQDLLQ----------------KQRD- 230

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966915597  651 aLQQLRTAVKELSVQN-QDLI-EKNLTL-QEHLRQAQpgsppSPDTAQLALE---LYQELASCLQ 709
Cdd:PRK11281  231 -YLTARIQRLEHQLQLlQEAInSKRLTLsEKTVQEAQ-----SQDEAARIQAnplVAQELEINLQ 289

ADIP

pfam11559

Afadin- and alpha -actinin-Binding; This family is found in mammals where it is localized at ...

564-682

2.42e-04

Afadin- and alpha -actinin-Binding; This family is found in mammals where it is localized at cell-cell adherens junctions, and in Sch. pombe and other fungi where it anchors spindle-pole bodies to spindle microtubules. It is a coiled-coil structure, and in pombe, it is required for anchoring the minus end of spindle microtubules to the centrosome equivalent, the spindle-pole body. The name ADIP derives from the family being composed of Afadin- and alpha -Actinin-Binding Proteins localized at Cell-Cell Adherens Junctions.

Pssm-ID: 463295 [Multi-domain] Cd Length: 151 Bit Score: 42.30 E-value: 2.42e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  564 LRQREAEFssaghslqdKQSVEETSGEgPEVEMESWQKQYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALRE 643
Cdd:pfam11559  46 QRDRDLEF---------RESLNETIRT-LEAEIERLQSKIERLKTQLEDLERELALLQAKERQLEKKLKTLEQKLKNEKE 115

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 966915597  644 EAQRRDSALQQLRTAvkelsvQNQDLIEKNL---TLQEHLRQ 682
Cdd:pfam11559 116 ELQRLKNALQQIKTQ------FAHEVKKRDReieKLKERLAQ 151

EnvC

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...

365-574

2.53e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];

Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 43.98 E-value: 2.53e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 365 KEKELL--IDKQRKHISQLEQKVRESELQVhsALLGRpapfgdvcllRLQELQRENTFLRAQFAQKTEALSREKIDLEKK 442
Cdd:COG4942   49 EEKALLkqLAALERRIAALARRIRALEQEL--AALEA----------ELAELEKEIAELRAELEAQKEELAELLRALYRL 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 443 LSASEVEVQLIRESLKVALQKhseeVKKQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLptLEDHQKQ 522
Cdd:COG4942  117 GRQPPLALLLSPEDFLDAVRR----LQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALLAEL--EEERAAL 190

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 966915597 523 SQQLKDSELKSTELQEKVTELESLLEETQAICRDRETQLESLRQREAEFSSA 574
Cdd:COG4942  191 EALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAER 242

PRK03918

DNA double-strand break repair ATPase Rad50;

354-662

2.67e-04

DNA double-strand break repair ATPase Rad50;

Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 44.67 E-value: 2.67e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 354 ISILNSNEHLLKEKELLIDKQRKHISQLEQKVRESElqvhsallgrpapfgdvcllRLQELQRENTFLRAQFAQKT-EAL 432
Cdd:PRK03918 330 IKELEEKEERLEELKKKLKELEKRLEELEERHELYE--------------------EAKAKKEELERLKKRLTGLTpEKL 389

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 433 SREKIDLEKKlsasevevqliRESLKVALQKHSEEVKKQEERVKGRDKHINNLKKKCQKESEQNRE--KQQRIETLERYL 510
Cdd:PRK03918 390 EKELEELEKA-----------KEEIEEEISKITARIGELKKEIKELKKAIEELKKAKGKCPVCGREltEEHRKELLEEYT 458

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 511 ADLPTLEdhqkqsQQLKDSELKSTELQEKVTELESLLEETQAICRDRET--QLESLRQREAEFssaghslqDKQSVEETS 588
Cdd:PRK03918 459 AELKRIE------KELKEIEEKERKLRKELRELEKVLKKESELIKLKELaeQLKELEEKLKKY--------NLEELEKKA 524

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966915597 589 GEGPEVEMESwqKQYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQ-EEGTSQALREEAQRRDSALQQLRTAVKEL 662
Cdd:PRK03918 525 EEYEKLKEKL--IKLKGEIKSLKKELEKLEELKKKLAELEKKLDElEEELAELLKELEELGFESVEELEERLKEL 597

Cast

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...

410-644

2.75e-04

Pssm-ID: 431111 [Multi-domain] Cd Length: 766 Bit Score: 44.43 E-value: 2.75e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  410 RLQElQRENtfLRAQFAQKTEALSREKIDLEKKLSASEVEVQLiRESLKVALQKH-----SEEVKKQ----------EER 474
Cdd:pfam10174 454 RLKE-QRER--EDRERLEELESLKKENKDLKEKVSALQPELTE-KESSLIDLKEHasslaSSGLKKDsklksleiavEQK 529

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  475 VKGRDKHINNLKKKCQKESEQ--NREKQQRIETLERylaDLPTLEDHQKQSQQ--------LKDSELKSTELQEKVTELE 544
Cdd:pfam10174 530 KEECSKLENQLKKAHNAEEAVrtNPEINDRIRLLEQ---EVARYKEESGKAQAeverllgiLREVENEKNDKDKKIAELE 606

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  545 SLleeTQAICRDRETQLESLRQREAEFSSAGHSLqdkqsVEETSGEGPEVEMESWQKQYDSLQKIVEKQQQKMDQLRSQV 624
Cdd:pfam10174 607 SL---TLRQMKEQNKKVANIKHGQQEMKKKGAQL-----LEEARRREDNLADNSQQLQLEELMGALEKTRQELDATKARL 678

                         250       260
                  ....*....|....*....|
gi 966915597  625 QSLEQEVAQEEGTSQALREE 644
Cdd:pfam10174 679 SSTQQSLAEKDGHLTNLRAE 698

DUF3584

pfam12128

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...

410-686

3.31e-04

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.

Pssm-ID: 432349 [Multi-domain] Cd Length: 1191 Bit Score: 44.44 E-value: 3.31e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   410 RLQELQRENTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRDKHINNLKK-- 487
Cdd:pfam12128  284 TSAELNQLLRTLDDQWKEKRDELNGELSAADAAVAKDRSELEALEDQHGAFLDADIETAAADQEQLPSWQSELENLEErl 363

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   488 -----KCQK-ESEQNREKQQRIETLERYLADLptledHQKQSQQLKDSELKSTELQEKVTELESLLEEtqaicrDRETQL 561
Cdd:pfam12128  364 kaltgKHQDvTAKYNRRRSKIKEQNNRDIAGI-----KDKLAKIREARDRQLAVAEDDLQALESELRE------QLEAGK 432

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   562 ESLRQREAEFSSAGHSLQDKQSVEETSgegPEVEMEswQKQYDSLqkiVEKQQQKMDQLRSQVQSLEQEVAQEEGtsqal 641
Cdd:pfam12128  433 LEFNEEEYRLKSRLGELKLRLNQATAT---PELLLQ--LENFDER---IERAREEQEAANAEVERLQSELRQARK----- 499

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 966915597   642 reeaqRRDSA----------LQQLRTAVKELSVQnqdLIEKNLTLQEHLRQAQPG 686
Cdd:pfam12128  500 -----RRDQAsealrqasrrLEERQSALDELELQ---LFPQAGTLLHFLRKEAPD 546

COG5022

Myosin heavy chain [General function prediction only];

405-685

3.49e-04

Myosin heavy chain [General function prediction only];

Pssm-ID: 227355 [Multi-domain] Cd Length: 1463 Bit Score: 44.30 E-value: 3.49e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  405 DVCLLRLQELQRENtFLRAQFAQKtealsREKIDLEKKLSASEVEVQLIRESLKVALQKHSEE---VKKQEERVKGRDKH 481
Cdd:COG5022   745 DNIATRIQRAIRGR-YLRRRYLQA-----LKRIKKIQVIQHGFRLRRLVDYELKWRLFIKLQPllsLLGSRKEYRSYLAC 818

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  482 INNLKKKCQKESEQN-REKQQR-------IETLERYLADLPTLEDHQKQS------QQLKDSELKSTELQEKVTELESL- 546
Cdd:COG5022   819 IIKLQKTIKREKKLReTEEVEFslkaevlIQKFGRSLKAKKRFSLLKKETiylqsaQRVELAERQLQELKIDVKSISSLk 898

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  547 --LEETQAICRDRETQLESLRQREAEFSSAgHSLQDKQSVEET-SGEGPEVEMESwqkqydslQKIVEKQQQKMDQLRSQ 623
Cdd:COG5022   899 lvNLELESEIIELKKSLSSDLIENLEFKTE-LIARLKKLLNNIdLEEGPSIEYVK--------LPELNKLHEVESKLKET 969

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966915597  624 VQSLEQEVAQEEgtsqALREEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQP 685
Cdd:COG5022   970 SEEYEDLLKKST----ILVREGNKANSELKNFKKELAELSKQYGALQESTKQLKELPVEVAE 1027

COG2433

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];

439-629

5.31e-04

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];

Pssm-ID: 441980 [Multi-domain] Cd Length: 644 Bit Score: 43.31 E-value: 5.31e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 439 LEKKLSAS----EVEVQLIR-ESLKVALQKHSEEVKKQEERVKGRDKHINNlkKKCQKESEQNREKQQRIETLERYLAdl 513
Cdd:COG2433  355 VEKKVPPDvdrdEVKARVIRgLSIEEALEELIEKELPEEEPEAEREKEHEE--RELTEEEEEIRRLEEQVERLEAEVE-- 430

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 514 ptledhqkqsqqlkdselkstELQEKVTELESLLEEtqaicrdRETQLESLRQREaefssaghslqdKQSVEEtsgegpE 593
Cdd:COG2433  431 ---------------------ELEAELEEKDERIER-------LERELSEARSEE------------RREIRK------D 464

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 966915597 594 VEMESWQKQYDSLQKIVEKQQQKMDQLRSQVQSLEQ 629
Cdd:COG2433  465 REISRLDREIERLERELEEERERIEELKRKLERLKE 500

Spc7

smart00787

Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...

411-546

5.55e-04

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.

Pssm-ID: 197874 [Multi-domain] Cd Length: 312 Bit Score: 42.70 E-value: 5.55e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   411 LQELQRENTFLRAQFAQkteaLSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRDKHINNLKKKCQ 490
Cdd:smart00787 153 LEGLKEDYKLLMKELEL----LNSIKPKLRDRKDALEEELRQLKQLEDELEDCDPTELDRAKEKLKKLLQEIMIKVKKLE 228

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   491 KESEQNREKQQRIETL----ERYLADLPTLEDHQKQSQQLKDSELKstELQEKVTELESL 546
Cdd:smart00787 229 ELEEELQELESKIEDLtnkkSELNTEIAEAEKKLEQCRGFTFKEIE--KLKEQLKLLQSL 286

PRK01156

chromosome segregation protein; Provisional

453-683

6.73e-04

chromosome segregation protein; Provisional

Pssm-ID: 100796 [Multi-domain] Cd Length: 895 Bit Score: 43.35 E-value: 6.73e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 453 IRESLKVALQKHSEEVKKQEERVKGRDKHINNLKKKcqkESEQNREKQQRIETLERYLADL-PTLEDHQKQSQQLKDSEL 531
Cdd:PRK01156 470 IINHYNEKKSRLEEKIREIEIEVKDIDEKIVDLKKR---KEYLESEEINKSINEYNKIESArADLEDIKIKINELKDKHD 546

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 532 KSTELQE-----KVTELESLLEE-TQAICRDRETQLESLRQREAEFSSAGHSLQDKqsVEETSGEGPEV---------EM 596
Cdd:PRK01156 547 KYEEIKNrykslKLEDLDSKRTSwLNALAVISLIDIETNRSRSNEIKKQLNDLESR--LQEIEIGFPDDksyidksirEI 624

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 597 ESWQKQYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALRE---EAQRRDSALQQLRTAVKELSVQN---QDLI 670
Cdd:PRK01156 625 ENEANNLNNKYNEIQENKILIEKLRGKIDNYKKQIAEIDSIIPDLKEitsRINDIEDNLKKSRKALDDAKANRarlESTI 704

                        250
                 ....*....|...
gi 966915597 671 EKNLTLQEHLRQA 683
Cdd:PRK01156 705 EILRTRINELSDR 717

CALCOCO1

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...

508-721

6.85e-04

Pssm-ID: 462303 [Multi-domain] Cd Length: 488 Bit Score: 42.96 E-value: 6.85e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  508 RYLADLPTLEDHQKQSQQLKD-------SELKSTELQEKVTELESLLEETQAICRDRETQLESLRQREAEFSSAGHSLQD 580
Cdd:pfam07888   1 KPLDELVTLEEESHGEEGGTDmllvvprAELLQNRLEECLQERAELLQAQEAANRQREKEKERYKRDREQWERQRRELES 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  581 KQSVEETSGEGPEVEMESWQKQYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVK 660
Cdd:pfam07888  81 RVAELKEELRQSREKHEELEEKYKELSASSEELSEEKDALLAQRAAHEARIRELEEDIKTLTQRVLERETELERMKERAK 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 966915597  661 ELSVQNQDLIEKNLTLQEHLRQAQPGSPPSPDTAQLALELYQELASCLQDLQAVCSIVTQR 721
Cdd:pfam07888 161 KAGAQRKEEEAERKQLQAKLQQTEEELRSLSKEFQELRNSLAQRDTQVLQLQDTITTLTQK 221

HEC1

COG5185

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...

471-649

7.76e-04

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];

Pssm-ID: 444066 [Multi-domain] Cd Length: 594 Bit Score: 43.02 E-value: 7.76e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 471 QEERVKGRDKHINNLKKKCQKESEQNREKQQRIE---TLERYLADLPTLEDHQKQSQQLKDSELKSTELQEKVTELESLL 547
Cdd:COG5185  273 NAESSKRLNENANNLIKQFENTKEKIAEYTKSIDikkATESLEEQLAAAEAEQELEESKRETETGIQNLTAEIEQGQESL 352

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 548 EETQAICRDRETQLES---LRQREAEFSSAGHSLqdkqsveETSGEGPEVEMESWQKQYDSLQKIVEK----QQQKMDQL 620
Cdd:COG5185  353 TENLEAIKEEIENIVGeveLSKSSEELDSFKDTI-------ESTKESLDEIPQNQRGYAQEILATLEDtlkaADRQIEEL 425

                        170       180
                 ....*....|....*....|....*....
gi 966915597 621 RSQVQSLEQEVAQEEGTSQALREEAQRRD 649
Cdd:COG5185  426 QRQIEQATSSNEEVSKLLNELISELNKVM 454

COG1340

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];

482-678

8.07e-04

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];

Pssm-ID: 440951 [Multi-domain] Cd Length: 297 Bit Score: 42.21 E-value: 8.07e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 482 INNLKKKCQKESEQNREKQQRIETLERYLADlpTLEDHQKQSQQLKD--SELKS--TELQEKVTELESLLEETQAICRDR 557
Cdd:COG1340   13 LEEKIEELREEIEELKEKRDELNEELKELAE--KRDELNAQVKELREeaQELREkrDELNEKVKELKEERDELNEKLNEL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 558 ETQLESLRQREAEFSSAGHSLQD-KQSVE------ETSGEGPEVEME------SWQKQYDSLQKIVEkQQQKMDQLRSQV 624
Cdd:COG1340   91 REELDELRKELAELNKAGGSIDKlRKEIErlewrqQTEVLSPEEEKElvekikELEKELEKAKKALE-KNEKLKELRAEL 169

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 966915597 625 QSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQE 678
Cdd:COG1340  170 KELRKEAEEIHKKIKELAEEAQELHEEMIELYKEADELRKEADELHKEIVEAQE 223

Smc

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...

364-769

8.89e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];

Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 43.00 E-value: 8.89e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 364 LKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRpapfgDVCLLRLQELQRENTFLRAQFAQKTEALSREKIDLEKKL 443
Cdd:COG1196  346 LEEAEEELEEAEAELAEAEEALLEAEAELAEAEEEL-----EELAEELLEALRAAAELAAQLEELEEAEEALLERLERLE 420

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 444 SASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLE-------RYLADLPTL 516
Cdd:COG1196  421 EELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEelaeaaaRLLLLLEAE 500

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 517 EDHQKQSQQLKDSELKS---------TELQEKVTELESLLEET------QAICRD-----------------RETQLESL 564
Cdd:COG1196  501 ADYEGFLEGVKAALLLAglrglagavAVLIGVEAAYEAALEAAlaaalqNIVVEDdevaaaaieylkaakagRATFLPLD 580

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 565 RQREAEFSSAGH-SLQDKQSVEETSGEGPEVEMESWQKQYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGT--SQAL 641
Cdd:COG1196  581 KIRARAALAAALaRGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEggSAGG 660

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 642 REEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQpgsppspdTAQLALELYQELASCLQDLQAVcsIVTQR 721
Cdd:COG1196  661 SLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEE--------EEERELAEAEEERLEEELEEEA--LEEQL 730

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*....
gi 966915597 722 AQGHDPNLSLLLGIHSQHPETQLDLQKPDVIKRKLE-EVQQLRRDIEDL 769
Cdd:COG1196  731 EAEREELLEELLEEEELLEEEALEELPEPPDLEELErELERLEREIEAL 779

SPEC

cd00176

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...

438-619

8.91e-04

Pssm-ID: 238103 [Multi-domain] Cd Length: 213 Bit Score: 41.28 E-value: 8.91e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 438 DLEKKLSASEVEVQLirESLKVALQKH---SEEVKKQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADL- 513
Cdd:cd00176   18 EKEELLSSTDYGDDL--ESVEALLKKHealEAELAAHEERVEALNELGEQLIEEGHPDAEEIQERLEELNQRWEELRELa 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 514 ----PTLEDHQKQSQQL------------KDSELKSTELQEKVTELESLLEETQAICRD---RETQLESLRQREAEFSSA 574
Cdd:cd00176   96 eerrQRLEEALDLQQFFrdaddleqwleeKEAALASEDLGKDLESVEELLKKHKELEEEleaHEPRLKSLNELAEELLEE 175

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 966915597 575 GHSLQDKQSveetsgegpEVEMESWQKQYDSLQKIVEKQQQKMDQ 619
Cdd:cd00176  176 GHPDADEEI---------EEKLEELNERWEELLELAEERQKKLEE 211

Yuri_gagarin

pfam15934

Yuri gagarin; The yuri gagarin protein found in Drosophila, it plays roles in spermatogenesis.

465-590

9.08e-04

Yuri gagarin; The yuri gagarin protein found in Drosophila, it plays roles in spermatogenesis.

Pssm-ID: 318204 [Multi-domain] Cd Length: 234 Bit Score: 41.48 E-value: 9.08e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  465 SEEVKKQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDhqkQSQQLKDSELKSTELQEKVTELE 544
Cdd:pfam15934  92 SENNRLKEEIHDLKQKNCVQARVVRKMGLELKGQEEQRVELCDKYESLLGSFEE---QCQELKRANRRVQSLQTRLSQVE 168

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 966915597  545 SLLEETQAICRDRETQLESLRQREAEFSSAGHSLQDKQSVEETSGE 590
Cdd:pfam15934 169 KLQEELRTERKILREEVIALKEKDAKSNGRERALQDQLKCCQTEIE 214

Filament

pfam00038

Intermediate filament protein;

423-684

9.34e-04

Intermediate filament protein;

Pssm-ID: 459643 [Multi-domain] Cd Length: 313 Bit Score: 42.21 E-value: 9.34e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  423 AQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQ-EERVKGRDK---HINNL-------KKKCQK 491
Cdd:pfam00038  14 ASYIDKVRFLEQQNKLLETKISELRQKKGAEPSRLYSLYEKEIEDLRRQlDTLTVERARlqlELDNLrlaaedfRQKYED 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  492 ESEQNREKQQRIETLERYLADLpTLE--DHQKQSQQLKDS-ELKSTELQEKVTELESLLEETQ--------------AIC 554
Cdd:pfam00038  94 ELNLRTSAENDLVGLRKDLDEA-TLArvDLEAKIESLKEElAFLKKNHEEEVRELQAQVSDTQvnvemdaarkldltSAL 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  555 RDRETQLESLRQReaefssaghslqDKQSVEETsgegpevemesWQKQYDSLQKIVEKQ-------QQKMDQLRSQVQSL 627
Cdd:pfam00038 173 AEIRAQYEEIAAK------------NREEAEEW-----------YQSKLEELQQAAARNgdalrsaKEEITELRRTIQSL 229

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 966915597  628 EQEVAQEEGTSQAL----REEAQRRDSALQQLRTAVKELSVQNQDLIEknlTLQEHLRQAQ 684
Cdd:pfam00038 230 EIELQSLKKQKASLerqlAETEERYELQLADYQELISELEAELQETRQ---EMARQLREYQ 287

DUF3584

pfam12128

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...

445-665

1.01e-03

Pssm-ID: 432349 [Multi-domain] Cd Length: 1191 Bit Score: 42.90 E-value: 1.01e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   445 ASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRDKHINNLKKK---CQKESEQNREKQQRIETLERYLADlpTLEDHQK 521
Cdd:pfam12128  597 ASEEELRERLDKAEEALQSAREKQAAAEEQLVQANGELEKASREetfARTALKNARLDLRRLFDEKQSEKD--KKNKALA 674

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   522 QSQQLKDSELKSTELQEKVTELE--SLLEETQAICRDRETQ-LESLRQREAEFSSAGHSLQDKQSVEETsgeGPEVEMES 598
Cdd:pfam12128  675 ERKDSANERLNSLEAQLKQLDKKhqAWLEEQKEQKREARTEkQAYWQVVEGALDAQLALLKAAIAARRS---GAKAELKA 751

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966915597   599 WQKQYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALRE-----------EAQRRDSALQQLRTAVKELSVQ 665
Cdd:pfam12128  752 LETWYKRDLASLGVDPDVIAKLKREIRTLERKIERIAVRRQEVLRyfdwyqetwlqRRPRLATQLSNIERAISELQQQ 829

COG4913

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];

556-705

1.15e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];

Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 42.59 E-value: 1.15e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  556 DRETQLESLRQREAEfssaghsLQDKQSVEETSGEGPEVEMESWQKQYDSLQKIVEKQ--QQKMDQLRSQVQSLEQEVAQ 633
Cdd:COG4913   607 DNRAKLAALEAELAE-------LEEELAEAEERLEALEAELDALQERREALQRLAEYSwdEIDVASAEREIAELEAELER 679

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  634 EEGTS---QALREEAQRRDSALQQLRTAVKELSVQNQDLiEKNLT-LQEHLRQAQP-----GSPPSPDTAQLALELYQEL 704
Cdd:COG4913   680 LDASSddlAALEEQLEELEAELEELEEELDELKGEIGRL-EKELEqAEEELDELQDrleaaEDLARLELRALLEERFAAA 758


                  .
gi 966915597  705 A 705
Cdd:COG4913   759 L 759

sbcc

TIGR00618

exonuclease SbcC; All proteins in this family for which functions are known are part of an ...

305-682

1.15e-03

Pssm-ID: 129705 [Multi-domain] Cd Length: 1042 Bit Score: 42.65 E-value: 1.15e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   305 EQSCELSTCRQQLELIRLQMEQmqlQNGAICHHPAAFAPSLPILEPAQWISILNSNEHLLKEKELLIdkQRKHISQLEQK 384
Cdd:TIGR00618  342 EQRRLLQTLHSQEIHIRDAHEV---ATSIREISCQQHTLTQHIHTLQQQKTTLTQKLQSLCKELDIL--QREQATIDTRT 416

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   385 VRESELQVHSALLGRPapfgdvcllrlQELQRENTFLRAQFAQKTEALSREKIDL---------EKKLSASEVEVQLIRE 455
Cdd:TIGR00618  417 SAFRDLQGQLAHAKKQ-----------QELQQRYAELCAAAITCTAQCEKLEKIHlqesaqslkEREQQLQTKEQIHLQE 485

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   456 SLKVALQKHSEEVKKQEER-VKGRDKHINN----------LKKKCQKESEQNREKQQRIETLERYL-ADLPTLEDHQKQS 523
Cdd:TIGR00618  486 TRKKAVVLARLLELQEEPCpLCGSCIHPNParqdidnpgpLTRRMQRGEQTYAQLETSEEDVYHQLtSERKQRASLKEQM 565

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   524 QQLKDSELKSTELQEKVTE--------LESLLEETQAICRDRETQLESLRQREAEFSSAGHSLQ---------DKQSVEE 586
Cdd:TIGR00618  566 QEIQQSFSILTQCDNRSKEdipnlqniTVRLQDLTEKLSEAEDMLACEQHALLRKLQPEQDLQDvrlhlqqcsQELALKL 645

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   587 TSGEGPEVEMeSWQKQYDSLQKIVEKQQQKMdqlrSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVKELSVQN 666
Cdd:TIGR00618  646 TALHALQLTL-TQERVREHALSIRVLPKELL----ASRQLALQKMQSEKEQLTYWKEMLAQCQTLLRELETHIEEYDREF 720

                          410
                   ....*....|....*.
gi 966915597   667 QDLIEKNLTLQEHLRQ 682
Cdd:TIGR00618  721 NEIENASSSLGSDLAA 736

MAD

pfam05557

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...

427-676

1.26e-03

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.

Pssm-ID: 461677 [Multi-domain] Cd Length: 660 Bit Score: 42.42 E-value: 1.26e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  427 QKTEALSREKIDLEKKLSASEVEVQLIRESLKValqkhseevkkQEERVKGRDKHINNLKKKCQKESEQNrekqQRIETL 506
Cdd:pfam05557 111 NELSELRRQIQRAELELQSTNSELEELQERLDL-----------LKAKASEAEQLRQNLEKQQSSLAEAE----QRIKEL 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  507 ERYLAdlptledhqkqsQQLKDSEL--KSTELQEKVTELESLLE----------ETQAICRDRETQLESLRQREAEFSSA 574
Cdd:pfam05557 176 EFEIQ------------SQEQDSEIvkNSKSELARIPELEKELErlrehnkhlnENIENKLLLKEEVEDLKRKLEREEKY 243

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  575 ghslQDKQSVEETSGEGPEVEMESWQKQY----------DSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREE 644
Cdd:pfam05557 244 ----REEAATLELEKEKLEQELQSWVKLAqdtglnlrspEDLSRRIEQLQQREIVLKEENSSLTSSARQLEKARRELEQE 319

                         250       260       270
                  ....*....|....*....|....*....|..
gi 966915597  645 AQRRDSALQQLRTAVKELSVQNQDLIEKNLTL 676
Cdd:pfam05557 320 LAQYLKKIEDLNKKLKRHKALVRRLQRRVLLL 351

MukB

COG3096

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...

497-704

1.42e-03

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];

Pssm-ID: 442330 [Multi-domain] Cd Length: 1470 Bit Score: 42.25 E-value: 1.42e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  497 REKQQRIETLERyladlpTLEDHQKQSQQLKDselKSTELQEKVTELESLL--------EETQAICRDRETQLESLRQRE 568
Cdd:COG3096   839 AALRQRRSELER------ELAQHRAQEQQLRQ---QLDQLKEQLQLLNKLLpqanlladETLADRLEELREELDAAQEAQ 909

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  569 AEFSSAGHSLQDKQSVEETSGEGPEvemeswqkQYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEE-----------GT 637
Cdd:COG3096   910 AFIQQHGKALAQLEPLVAVLQSDPE--------QFEQLQADYLQAKEQQRRLKQQIFALSEVVQRRPhfsyedavgllGE 981

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  638 SQALRE---------EAQRRDsALQQLRTAVKELSVQNQDLIE-------KNLTLQEHLRQ-AQPGSPPSPDTAQLAL-- 698
Cdd:COG3096   982 NSDLNEklrarleqaEEARRE-AREQLRQAQAQYSQYNQVLASlkssrdaKQQTLQELEQElEELGVQADAEAEERARir 1060


                  ....*...
gi 966915597  699 --ELYQEL 704
Cdd:COG3096  1061 rdELHEEL 1068

PRK11637

AmiB activator; Provisional

454-651

1.82e-03

AmiB activator; Provisional

Pssm-ID: 236942 [Multi-domain] Cd Length: 428 Bit Score: 41.60 E-value: 1.82e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 454 RESLKVALQKHSEEVKKQEERVKGRDKHINNLKKKCQ---KESEQNREKQQRIETLERYLADLPT----LEDHQKQSQQL 526
Cdd:PRK11637  46 RDQLKSIQQDIAAKEKSVRQQQQQRASLLAQLKKQEEaisQASRKLRETQNTLNQLNKQIDELNAsiakLEQQQAAQERL 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 527 KDSELKSTELQEKVTELESLL--EETQAICR----------DRETQLESLRQREAEFSSAGHSLQDKQSVEET------- 587
Cdd:PRK11637 126 LAAQLDAAFRQGEHTGLQLILsgEESQRGERilayfgylnqARQETIAELKQTREELAAQKAELEEKQSQQKTllyeqqa 205

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966915597 588 SGEGPEVEMESWQKQYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQAlREEAQRRDSA 651
Cdd:PRK11637 206 QQQKLEQARNERKKTLTGLESSLQKDQQQLSELRANESRLRDSIARAEREAKA-RAEREAREAA 268

rad50

TIGR00606

rad50; All proteins in this family for which functions are known are involvedin recombination, ...

426-682

1.83e-03

Pssm-ID: 129694 [Multi-domain] Cd Length: 1311 Bit Score: 41.96 E-value: 1.83e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   426 AQKTEALSREKidLEKKLSASEVEV-QLIRESLKVALQKHSEEVKKQEERVKGRDKHINNLKKKCQKESEQNREKQQRIE 504
Cdd:TIGR00606  273 ALKSRKKQMEK--DNSELELKMEKVfQGTDEQLNDLYHNHQRTVREKERELVDCQRELEKLNKERRLLNQEKTELLVEQG 350

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   505 TLERyladlpTLEDHQKQSQQlKDSELKSTELQEKVTELESLLEETQAICRDRETQLESLRQREAEFSSAGHSLQDKQSV 584
Cdd:TIGR00606  351 RLQL------QADRHQEHIRA-RDSLIQSLATRLELDGFERGPFSERQIKNFHTLVIERQEDEAKTAAQLCADLQSKERL 423

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   585 EETSGEGPEVEMESWQKQYDSLQKIVEKQQQKMDQLRSQVQSLEQE----VAQEEGTSQALREEAQ-RRDSALQQLRTAV 659
Cdd:TIGR00606  424 KQEQADEIRDEKKGLGRTIELKKEILEKKQEELKFVIKELQQLEGSsdriLELDQELRKAERELSKaEKNSLTETLKKEV 503

                          250       260
                   ....*....|....*....|...
gi 966915597   660 KELSVQNQDLIEKNLTLQEHLRQ 682
Cdd:TIGR00606  504 KSLQNEKADLDRKLRKLDQEMEQ 526

COG4372

Uncharacterized protein, contains DUF3084 domain [Function unknown];

408-702

1.84e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];

Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 41.43 E-value: 1.84e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 408 LLRLQELQRENTFLRAQFAQKTEalsrEKIDLEKKLSASEVEVQLIRESLKVA---LQKHSEEVKKQEERVKGRDKHINN 484
Cdd:COG4372   37 LFELDKLQEELEQLREELEQARE----ELEQLEEELEQARSELEQLEEELEELneqLQAAQAELAQAQEELESLQEEAEE 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 485 LKKKCQKESEQNREKQQRIETLERYLADLptLEDHQKQSQQLKDSELKSTELQEKVTELESLLEETQAicRDRETQLESL 564
Cdd:COG4372  113 LQEELEELQKERQDLEQQRKQLEAQIAEL--QSEIAEREEELKELEEQLESLQEELAALEQELQALSE--AEAEQALDEL 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 565 RqREAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQKQYDSLQKIVEKQQQKmDQLRSQVQSLEQEVAQEEGTSQALREE 644
Cdd:COG4372  189 L-KEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALL-DALELEEDKEELLEEVILKEIEELELA 266

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 966915597 645 AQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQPGSPPSPDTAQLALELYQ 702
Cdd:COG4372  267 ILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALLEL 324

PRK12704

phosphodiesterase; Provisional

428-567

1.87e-03

phosphodiesterase; Provisional

Pssm-ID: 237177 [Multi-domain] Cd Length: 520 Bit Score: 41.69 E-value: 1.87e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 428 KTEALSREKidlEKKLSASEvEVQLIRESLKVALQKHSEEVKKQEERVKgrdKHINNLKKKcqkeSEQNREKQQRIETLE 507
Cdd:PRK12704  48 KKEAEAIKK---EALLEAKE-EIHKLRNEFEKELRERRNELQKLEKRLL---QKEENLDRK----LELLEKREEELEKKE 116

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966915597 508 RYLadlptledhqkqSQQLKDSELKSTELQEKVTELESLLEETQAICRD--RETQLESLRQR 567
Cdd:PRK12704 117 KEL------------EQKQQELEKKEEELEELIEEQLQELERISGLTAEeaKEILLEKVEEE 166

PRK10246

exonuclease subunit SbcC; Provisional

315-682

2.12e-03

exonuclease subunit SbcC; Provisional

Pssm-ID: 182330 [Multi-domain] Cd Length: 1047 Bit Score: 41.71 E-value: 2.12e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  315 QQLELIRLQMEQMQLQNGAICHHPAAfAPSLPILEPAQWISILNSNEHLLKEKELLIDKQRKHIS----------QLEQK 384
Cdd:PRK10246  251 RLDELQQEASRRQQALQQALAAEEKA-QPQLAALSLAQPARQLRPHWERIQEQSAALAHTRQQIEevntrlqstmALRAR 329

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  385 VRESELQVHSALLgrpapfgdvcllrlQELQRENTFL----------------RAQFAQKT------EALSREKIDLEKK 442
Cdd:PRK10246  330 IRHHAAKQSAELQ--------------AQQQSLNTWLaehdrfrqwnnelagwRAQFSQQTsdreqlRQWQQQLTHAEQK 395

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  443 LSA-SEVEVQLIRESLKVALQKHSEEvkkqeervkgrdkhiNNLKKKCQKESEQNREKQQRIETLERYLADLPTleDHQK 521
Cdd:PRK10246  396 LNAlPAITLTLTADEVAAALAQHAEQ---------------RPLRQRLVALHGQIVPQQKRLAQLQVAIQNVTQ--EQTQ 458

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  522 QSQQLKDSELKSTELQEKVTELESLLEETQAIcrdreTQLESLRQReaefssaghsLQDKQSVEET-SGEGPEV------ 594
Cdd:PRK10246  459 RNAALNEMRQRYKEKTQQLADVKTICEQEARI-----KDLEAQRAQ----------LQAGQPCPLCgSTSHPAVeayqal 523

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  595 EMESWQKQYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLrTAVKELSVQNQDLIEKNL 674
Cdd:PRK10246  524 EPGVNQSRLDALEKEVKKLGEEGAALRGQLDALTKQLQRDESEAQSLRQEEQALTQQWQAV-CASLNITLQPQDDIQPWL 602


                  ....*...
gi 966915597  675 TLQEHLRQ 682
Cdd:PRK10246  603 DAQEEHER 610

MAD

pfam05557

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...

520-775

2.22e-03

Pssm-ID: 461677 [Multi-domain] Cd Length: 660 Bit Score: 41.65 E-value: 2.22e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  520 QKQSQQLKDSELKSTELQEKVTELESLLEETQAICRDRETQLESLRQREAEFSSAGHSlqdkqsveetsgegpEVEMESW 599
Cdd:pfam05557  16 NEKKQMELEHKRARIELEKKASALKRQLDRESDRNQELQKRIRLLEKREAEAEEALRE---------------QAELNRL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  600 QKQY-DSLQKIVEKQQQKMDQLRSQVQSLEQEVAqeegtsqALREEAQRRDSALQQLRTAVKELSVQNqDLIEKNLTLQE 678
Cdd:pfam05557  81 KKKYlEALNKKLNEKESQLADAREVISCLKNELS-------ELRRQIQRAELELQSTNSELEELQERL-DLLKAKASEAE 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  679 HLRQAQPGSPPSPDTAQLAL-ELYQELASCLQDlqavcSIVTQRAQghdpnlSLLLGIHsqhpetqlDLQKpdvikrkle 757
Cdd:pfam05557 153 QLRQNLEKQQSSLAEAEQRIkELEFEIQSQEQD-----SEIVKNSK------SELARIP--------ELEK--------- 204

                         250
                  ....*....|....*...
gi 966915597  758 EVQQLRRDIEDLRTTMSD 775
Cdd:pfam05557 205 ELERLREHNKHLNENIEN 222

DR0291

COG1579

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...

454-567

2.32e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];

Pssm-ID: 441187 [Multi-domain] Cd Length: 236 Bit Score: 40.29 E-value: 2.32e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 454 RESLKVALQKHSEEVKKQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPT---LEDHQKQSQQLK--- 527
Cdd:COG1579   26 LKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVRNnkeYEALQKEIESLKrri 105

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 966915597 528 -DSELKSTELQEKVTELESLLEETQAICRDRETQLESLRQR 567
Cdd:COG1579  106 sDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAE 146

COG4372

Uncharacterized protein, contains DUF3084 domain [Function unknown];

449-674

2.38e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];

Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 41.04 E-value: 2.38e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 449 EVQLIRESLKVALQKHSEEVKKQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLadlptledhQKQSQQLKD 528
Cdd:COG4372    7 KVGKARLSLFGLRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEEL---------EQARSELEQ 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 529 SELKSTELQEKVTELESLLEETQAICRDRETQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQKQYDSLQK 608
Cdd:COG4372   78 LEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEE 157

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966915597 609 IVEKQQQKMDQLRSQVQSLEQEVAQEEgtSQALREEAQRRDSALQQLRTAVKELSVQNQDLIEKNL 674
Cdd:COG4372  158 QLESLQEELAALEQELQALSEAEAEQA--LDELLKEANRNAEKEEELAEAEKLIESLPRELAEELL 221

COG4913

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];

482-662

2.44e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];

Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 41.44 E-value: 2.44e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  482 INNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKSTELQEKVTELE---SLLEETQAICRDRE 558
Cdd:COG4913   612 LAALEAELAELEEELAEAEERLEALEAELDALQERREALQRLAEYSWDEIDVASAEREIAELEaelERLDASSDDLAALE 691

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  559 TQLESLRQREAEFSSAGHSLQDKQSVEETsgegpevEMESWQKQYDSLQKIVE-KQQQKMDQLRSQVQSLEQEVAQEEGT 637
Cdd:COG4913   692 EQLEELEAELEELEEELDELKGEIGRLEK-------ELEQAEEELDELQDRLEaAEDLARLELRALLEERFAAALGDAVE 764

                         170       180
                  ....*....|....*....|....*
gi 966915597  638 SQALREEAQRRDSALQQLRTAVKEL 662
Cdd:COG4913   765 RELRENLEERIDALRARLNRAEEEL 789

mukB

chromosome partition protein MukB;

410-687

2.56e-03

chromosome partition protein MukB;

Pssm-ID: 235316 [Multi-domain] Cd Length: 1486 Bit Score: 41.48 E-value: 2.56e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  410 RLQELQRENTFLRAQFAQKTEAL--SREKIDLEKKLsASEVEVqLIRESLKVALQKHSEEVKKQEER---VKGRDKHINN 484
Cdd:PRK04863  845 RRVELERALADHESQEQQQRSQLeqAKEGLSALNRL-LPRLNL-LADETLADRVEEIREQLDEAEEAkrfVQQHGNALAQ 922

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  485 LKK-------------KCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSElKSTELQEKvteLESLLEETQ 551
Cdd:PRK04863  923 LEPivsvlqsdpeqfeQLKQDYQQAQQTQRDAKQQAFALTEVVQRRAHFSYEDAAEMLA-KNSDLNEK---LRQRLEQAE 998

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  552 AicrDRETQLESLRQREAEFSSAGHSLQDKQSveetsgegpevemeswqkQYDSLQKIVEKQQQKMDQLRSQVQS--LEQ 629
Cdd:PRK04863  999 Q---ERTRAREQLRQAQAQLAQYNQVLASLKS------------------SYDAKRQMLQELKQELQDLGVPADSgaEER 1057

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  630 EVAQEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDL--IEKNLTLQEHLRQAQPGS 687
Cdd:PRK04863 1058 ARARRDELHARLSANRSRRNQLEKQLTFCEAEMDNLTKKLrkLERDYHEMREQVVNAKAG 1117

PRK03918

DNA double-strand break repair ATPase Rad50;

466-681

2.85e-03

DNA double-strand break repair ATPase Rad50;

Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 41.20 E-value: 2.85e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 466 EEVKKQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLAdlptledhqKQSQQLKDSELKSTELQEKVTELES 545
Cdd:PRK03918 158 DDYENAYKNLGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELE---------EVLREINEISSELPELREELEKLEK 228

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 546 LLEETQAIcrdrETQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQKQYDSLQKIVEKQQQ--KMDQLRSQ 623
Cdd:PRK03918 229 EVKELEEL----KEEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKELKEKAEEyiKLSEFYEE 304

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 966915597 624 VQSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLR 681
Cdd:PRK03918 305 YLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRLEELEERHE 362

MAP65_ASE1

pfam03999

Microtubule associated protein (MAP65/ASE1 family);

457-681

2.96e-03

Microtubule associated protein (MAP65/ASE1 family);

Pssm-ID: 427641 [Multi-domain] Cd Length: 477 Bit Score: 40.76 E-value: 2.96e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  457 LKVALQKHSEEVKKQEERVKGRDKHINNLKKKCQKESEQNREK-QQRIETLERYLADLPTLEDHQKQSQQLKDSELKste 535
Cdd:pfam03999   7 LHVIWQEIGFSEDKRLQILSRLKDHIKEFYTDALSEENDKEQRiLQSIADLRAEAAILCLYMRNRLLHEERDPFEPK--- 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  536 lqekvtELESLLEETQAICRDRETQLESLRQREAEFSSAGHslQDKQSVEETSGEG--------PEVE-MESWQKQYDSL 606
Cdd:pfam03999  84 ------KGMSLLQKEKKLDTQLEHLRKEKAPRLAEIKELLE--QLQQLCEELGEEPlpllidplPSLEeLESFRKHLENL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  607 QKIVEKQQQKMDQLRSQVQSL------------EQEVAQEEGTSQAL-REEAQRRDSALQQLRTAVKELSVQNQDLIEKN 673
Cdd:pfam03999 156 RNEKERRLEEVNELKKQIKLLmeeldlvpgtdfEEDLLCESEDNFCLsRENIDKLRKLIKQLEEQKAEREEKIDDLREKI 235


                  ....*...
gi 966915597  674 LTLQEHLR 681
Cdd:pfam03999 236 LELWNRLQ 243

PRK12704

phosphodiesterase; Provisional

516-647

3.08e-03

phosphodiesterase; Provisional

Pssm-ID: 237177 [Multi-domain] Cd Length: 520 Bit Score: 40.92 E-value: 3.08e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 516 LEDHQKQSQQLKdsELKSTELQEKVTELESLLEETqaiCRDRETQL----ESLRQREAEFSSAGHSLQDKqsveetsgeg 591
Cdd:PRK12704  44 LEEAKKEAEAIK--KEALLEAKEEIHKLRNEFEKE---LRERRNELqkleKRLLQKEENLDRKLELLEKR---------- 108

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966915597 592 pEVEMESWQKQYDSLQKIVEKQQQKMDQLRS-QVQSLEqEVA---QEEGTSQAL---REEAQR 647
Cdd:PRK12704 109 -EEELEKKEKELEQKQQELEKKEEELEELIEeQLQELE-RISgltAEEAKEILLekvEEEARH 169

Rabaptin

pfam03528

Rabaptin;

422-684

3.27e-03

Rabaptin;

Pssm-ID: 367545 [Multi-domain] Cd Length: 486 Bit Score: 40.86 E-value: 3.27e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  422 RAQFAQKTEALSREKIDLEKKLSASEVEvqlirESLKVALQKHSEEVKKQEERVKGRDKHINNLKKKCQ------KESEQ 495
Cdd:pfam03528 132 RAQWNQYRESAEREIADLRRRLSEGQEE-----ENLEDEMKKAQEDAEKLRSVVMPMEKEIAALKAKLTeaedkiKELEA 206

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  496 NR----------EKQQRIEtLERYLADLPTledhQKQSQQlKDSElkstELQEKVTELESLLEETqaicRDRETQLESLR 565
Cdd:pfam03528 207 SKmkelnhyleaEKSCRTD-LEMYVAVLNT----QKSVLQ-EDAE----KLRKELHEVCHLLEQE----RQQHNQLKHTW 272

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  566 QREAE--FSSAGHSLQDKQSVEE--TSGEGPEVEM--ESWQKQYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEgTSQ 639
Cdd:pfam03528 273 QKANDqfLESQRLLMRDMQRMESvlTSEQLRQVEEikKKDQEEHKRARTHKEKETLKSDREHTVSIHAVFSPAGVE-TSA 351

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 966915597  640 ALREEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTL-QEHLRQAQ 684
Cdd:pfam03528 352 PLSNVEEQINSAHGSVHSLDTDVVLGAGDSFNKQEDPfKEGLRRAQ 397

COG4372

Uncharacterized protein, contains DUF3084 domain [Function unknown];

531-684

3.34e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];

Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 40.66 E-value: 3.34e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 531 LKSTELQEKVTELESLLEETQAICRDRETQLESLRQREAEFSSAGHSLQDKQSveetsgegpevEMESWQKQYDSLQKIV 610
Cdd:COG4372   28 ALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEE-----------ELEELNEQLQAAQAEL 96

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966915597 611 EKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQ 684
Cdd:COG4372   97 AQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALE 170

PRK03918

DNA double-strand break repair ATPase Rad50;

354-549

3.50e-03

DNA double-strand break repair ATPase Rad50;

Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 40.82 E-value: 3.50e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 354 ISILNSNehlLKEKELLIDKQRKhisqLEQKVRESELQVhSALLGRPAPFGDVCL----LRLQELQR-ENTFLRAQFAQK 428
Cdd:PRK03918 541 IKSLKKE---LEKLEELKKKLAE----LEKKLDELEEEL-AELLKELEELGFESVeeleERLKELEPfYNEYLELKDAEK 612

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 429 -----TEALSREKIDLEK---KLSASEVEVQLIRESLKVALQKHSEE---------------VKKQEERVKGRDKHINNL 485
Cdd:PRK03918 613 elereEKELKKLEEELDKafeELAETEKRLEELRKELEELEKKYSEEeyeelreeylelsreLAGLRAELEELEKRREEI 692

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966915597 486 KK---KCQKESEQNREKQQRIETLERYLADLptledhqkqsqqlkdselksTELQEKVTELESLLEE 549
Cdd:PRK03918 693 KKtleKLKEELEEREKAKKELEKLEKALERV--------------------EELREKVKKYKALLKE 739

Cast

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...

439-676

4.18e-03

Pssm-ID: 431111 [Multi-domain] Cd Length: 766 Bit Score: 40.58 E-value: 4.18e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  439 LEKKLSASEVEVQLIREslkvalQKHSEEVKKQEErVKGRDKHINNLKkkcQKESEQNREKQQRietlERYLADLPTLED 518
Cdd:pfam10174 441 LEEALSEKERIIERLKE------QREREDRERLEE-LESLKKENKDLK---EKVSALQPELTEK----ESSLIDLKEHAS 506

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  519 HQKQSQQLKDSELKSTELQ-----EKVTELESLLEETQAICRDRETQLE---SLRQREAEFSSAGHSLQDKQS-VEETSG 589
Cdd:pfam10174 507 SLASSGLKKDSKLKSLEIAveqkkEECSKLENQLKKAHNAEEAVRTNPEindRIRLLEQEVARYKEESGKAQAeVERLLG 586

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  590 EGPEVEMESWQKQydslQKIVEKQQQKMDQLRSQ---------VQSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVK 660
Cdd:pfam10174 587 ILREVENEKNDKD----KKIAELESLTLRQMKEQnkkvanikhGQQEMKKKGAQLLEEARRREDNLADNSQQLQLEELMG 662

                         250
                  ....*....|....*.
gi 966915597  661 ELSVQNQDLIEKNLTL 676
Cdd:pfam10174 663 ALEKTRQELDATKARL 678

PLN02939

transferase, transferring glycosyl groups

361-648

5.01e-03

transferase, transferring glycosyl groups

Pssm-ID: 215507 [Multi-domain] Cd Length: 977 Bit Score: 40.66 E-value: 5.01e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 361 EHLLKEKELLidkQRKhISQLEQKVRESELQVHSALLGRpapfgdvclLRLQELQRENTFLRAQFAQKTEALSREKIDLE 440
Cdd:PLN02939 159 EKILTEKEAL---QGK-INILEMRLSETDARIKLAAQEK---------IHVEILEEQLEKLRNELLIRGATEGLCVHSLS 225

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 441 KKLSASEVEVQLIRESLKvALQKHSEEVKKQEERVKgrdkhinNLKKKCQKESEQNREkqqrietLERYLADlptledhq 520
Cdd:PLN02939 226 KELDVLKEENMLLKDDIQ-FLKAELIEVAETEERVF-------KLEKERSLLDASLRE-------LESKFIV-------- 282

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 521 KQSQQLKDSELKSTELQEKVTELESLLEETQaicrDRETQLESLRQREaefssagHSLQDKQSVEETSGEGPEVEMESWQ 600
Cdd:PLN02939 283 AQEDVSKLSPLQYDCWWEKVENLQDLLDRAT----NQVEKAALVLDQN-------QDLRDKVDKLEASLKEANVSKFSSY 351

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 966915597 601 KqYDSLQ---KIVEKQQQKMDQ-LRSQVQSLEQEVAQEEGTSQALREEAQRR 648
Cdd:PLN02939 352 K-VELLQqklKLLEERLQASDHeIHSYIQLYQESIKEFQDTLSKLKEESKKR 402

DUF3584

pfam12128

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...

490-769

5.55e-03

Pssm-ID: 432349 [Multi-domain] Cd Length: 1191 Bit Score: 40.21 E-value: 5.55e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   490 QKESEQNREKQQRiETLERYLADL----------PTLEDHQKQSQQLKDSELKSTELQEKVTELESLLEETQAICRDRET 559
Cdd:pfam12128  208 DDGVVPPKSRLNR-QQVEHWIRDIqaiagimkirPEFTKLQQEFNTLESAELRLSHLHFGYKSDETLIASRQEERQETSA 286

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   560 QLES-LRQREAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQKQYDSLQKI-VEK---QQQKMDQLRSQVQSLEQEVAQE 634
Cdd:pfam12128  287 ELNQlLRTLDDQWKEKRDELNGELSAADAAVAKDRSELEALEDQHGAFLDAdIETaaaDQEQLPSWQSELENLEERLKAL 366

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597   635 EGTSQALREEAQRRDSALQQlrtavkelsvQNQDLIEKNLTLQEHLRQAQPGSPPSPDTAQLALElyQELASCLQDLQAV 714
Cdd:pfam12128  367 TGKHQDVTAKYNRRRSKIKE----------QNNRDIAGIKDKLAKIREARDRQLAVAEDDLQALE--SELREQLEAGKLE 434

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 966915597   715 CSIVTQRAQGHDPNLSLLLGIHSQHPETQLDL-QKPDVIKRKLEEVQQLRRDIEDL 769
Cdd:pfam12128  435 FNEEEYRLKSRLGELKLRLNQATATPELLLQLeNFDERIERAREEQEAANAEVERL 490

HMMR_N

pfam15905

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ...

425-682

6.73e-03

Pssm-ID: 464932 [Multi-domain] Cd Length: 329 Bit Score: 39.41 E-value: 6.73e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  425 FAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEErvkgrdkhinnLKKKCQKESEQNREKQQRIE 504
Cdd:pfam15905  29 FRKQKAAESQPNLNNSKDASTPATARKVKSLELKKKSQKNLKESKDQKE-----------LEKEIRALVQERGEQDKRLQ 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  505 TLEryladlptlEDHQKQSQQLKDSELKSTELQEKVTELESLLEET-------QAICRDRETQlESLRQREAEFSSAGHS 577
Cdd:pfam15905  98 ALE---------EELEKVEAKLNAAVREKTSLSASVASLEKQLLELtrvnellKAKFSEDGTQ-KKMSSLSMELMKLRNK 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  578 LQDKQSVEETSGEGPEVEMESwqkqydsLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRT 657
Cdd:pfam15905 168 LEAKMKEVMAKQEGMEGKLQV-------TQKNLEHSKGKVAQLEEKLVSTEKEKIEEKSETEKLLEYITELSCVSEQVEK 240

                         250       260
                  ....*....|....*....|....*...
gi 966915597  658 AVKELSVQNQDLIEKN---LTLQEHLRQ 682
Cdd:pfam15905 241 YKLDIAQLEELLKEKNdeiESLKQSLEE 268

Mplasa_alph_rch

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...

438-678

6.76e-03

Pssm-ID: 275316 [Multi-domain] Cd Length: 745 Bit Score: 40.00 E-value: 6.76e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  438 DLEKKLSASEVEV---QLIRESLKVALQKHSEEVKKQEERVKGRDKHINNLKKKCQKESeqnrekqQRIETLERYLADLP 514
Cdd:TIGR04523  37 QLEKKLKTIKNELknkEKELKNLDKNLNKDEEKINNSNNKIKILEQQIKDLNDKLKKNK-------DKINKLNSDLSKIN 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  515 TLEDHQKQSQQLKDSELKSTELQEK------------VTELESLLEETQAICRDRETQLESLRQREAEFSSAGHSLQ--- 579
Cdd:TIGR04523 110 SEIKNDKEQKNKLEVELNKLEKQKKenkknidkflteIKKKEKELEKLNNKYNDLKKQKEELENELNLLEKEKLNIQkni 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  580 DKQSVEETSGEGPEVEMESWQKQYDSLQKIVEKQQQKMDQLRSQVQSLEQE----VAQEEGTSQALREEAQRRDSALQQL 655
Cdd:TIGR04523 190 DKIKNKLLKLELLLSNLKKKIQKNKSLESQISELKKQNNQLKDNIEKKQQEinekTTEISNTQTQLNQLKDEQNKIKKQL 269

                         250       260
                  ....*....|....*....|...
gi 966915597  656 RTAVKELSVQNQDLIEKNLTLQE 678
Cdd:TIGR04523 270 SEKQKELEQNNKKIKELEKQLNQ 292

Mplasa_alph_rch

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...

356-677

7.11e-03

Pssm-ID: 275316 [Multi-domain] Cd Length: 745 Bit Score: 40.00 E-value: 7.11e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  356 ILNSNEHLLKEKELLIDKQRKHISQLEQKVREselqvhsallgrpapfgdvclLRLQELQRENTFlrAQFAQKTEALSRE 435
Cdd:TIGR04523  27 IANKQDTEEKQLEKKLKTIKNELKNKEKELKN---------------------LDKNLNKDEEKI--NNSNNKIKILEQQ 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  436 KIDLEKKLSASEVEV-QLIRESLKVALQ---------KHSEEVKKQEERVKGRDKHIN-------NLKKKCQKESEQNRE 498
Cdd:TIGR04523  84 IKDLNDKLKKNKDKInKLNSDLSKINSEikndkeqknKLEVELNKLEKQKKENKKNIDkflteikKKEKELEKLNNKYND 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  499 KQQRIETLERY----------------------------LADLPTL-EDHQKQSQQLKDSELKSTELQEKVTELESLLEE 549
Cdd:TIGR04523 164 LKKQKEELENElnllekeklniqknidkiknkllklellLSNLKKKiQKNKSLESQISELKKQNNQLKDNIEKKQQEINE 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  550 TQAICRDRETQLESLRQREAEfssAGHSLQDKQS--------VEETSGEGPEVEME----SWQKQYD---SLQKIVEKQQ 614
Cdd:TIGR04523 244 KTTEISNTQTQLNQLKDEQNK---IKKQLSEKQKeleqnnkkIKELEKQLNQLKSEisdlNNQKEQDwnkELKSELKNQE 320

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966915597  615 QKMDQLRSQ-------VQSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDLIE--KNLTLQ 677
Cdd:TIGR04523 321 KKLEEIQNQisqnnkiISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQeiKNLESQ 392

Tektin

pfam03148

Tektin family; Tektins are cytoskeletal proteins. They have been demonstrated in such cellular ...

413-677

7.75e-03

Tektin family; Tektins are cytoskeletal proteins. They have been demonstrated in such cellular sites as centrioles, basal bodies, and along ciliary and flagellar doublet microtubules. Tektins form unique protofilaments, organized as longitudinal polymers of tektin heterodimers with axial periodicity matching tubulin. Tektin polypeptides consist of several alpha-helical regions that are predicted to form coiled coils. Indeed, tektins share considerable structural similarities with intermediate filament proteins. Possible functional roles for tektins are: stabilization of tubulin protofilaments; attachment of A and B-tubules in ciliary/flagellar microtubule doublets and C-tubules in centrioles; binding of axonemal components.

Pssm-ID: 460827 [Multi-domain] Cd Length: 383 Bit Score: 39.45 E-value: 7.75e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  413 ELQREntflRAQFAQKTEALSREKIDLEKKLSAS-------------------------EVEVQLIRE-----SLKVALQ 462
Cdd:pfam03148  61 ELEKE----LEELDEEIELLLEEKRRLEKALEALeeplhiaqecltlrekrqgidlvhdEVEKELLKEvelieGIQELLQ 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  463 KHSEEVKKQEERVKG---------RDKHIN-NLKKKCQKESEQNREKQQRiETLERYLADLPTLEDHQKQSQQLK---DS 529
Cdd:pfam03148 137 RTLEQAWEQLRLLRAarhklekdlSDKKEAlEIDEKCLSLNNTSPNISYK-PGPTRIPPNSSTPEEWEKFTQDNIeraEK 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  530 EL-KSTELQEkvtELESLLEETQAICRD-RETQLESLRQREAEFSSAGHSLQD-KQSVEEtsgegpevEMESWQKQYDSL 606
Cdd:pfam03148 216 ERaASAQLRE---LIDSILEQTANDLRAqADAVNFALRKRIEETEDAKNKLEWqLKKTLQ--------EIAELEKNIEAL 284

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  607 QK-IVEK---------------QQQKMDQLRSQVQ-SLEQEVAQEEGTSQALREEAQRRDSALQQLrtaVKELSVQNQDL 669
Cdd:pfam03148 285 EKaIRDKeaplklaqtrlenrtYRPNVELCRDEAQyGLVDEVKELEETIEALKQKLAEAEASLQAL---ERTRLRLEEDI 361


                  ....*...
gi 966915597  670 IEKNLTLQ 677
Cdd:pfam03148 362 AVKANSLF 369

PRK03918

DNA double-strand break repair ATPase Rad50;

408-586

8.35e-03

DNA double-strand break repair ATPase Rad50;

Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 39.66 E-value: 8.35e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 408 LLRLQELQREntflRAQFAQKTEALSREKIDLEKKLS----ASEVEVQLIRESLKVALQKHSEeVKKQEERVKGRDKHIN 483
Cdd:PRK03918 548 LEKLEELKKK----LAELEKKLDELEEELAELLKELEelgfESVEELEERLKELEPFYNEYLE-LKDAEKELEREEKELK 622

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597 484 NLKKKCQKESEQNREKQQRIETLERYLADLPTL---EDHQKQSQQLKDSELKSTELQEKVTELESLLEETQAICRDRETQ 560
Cdd:PRK03918 623 KLEEELDKAFEELAETEKRLEELRKELEELEKKyseEEYEELREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEE 702

                        170       180
                 ....*....|....*....|....*.
gi 966915597 561 LESLRQREAEFSSAGHSLQDKQSVEE 586
Cdd:PRK03918 703 LEEREKAKKELEKLEKALERVEELRE 728

CCDC22

pfam05667

Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 ...

499-658

8.39e-03

Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. It is part of the OMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. This entry also includes CCDC22 homologs from animals and plants.

Pssm-ID: 461708 [Multi-domain] Cd Length: 600 Bit Score: 39.63 E-value: 8.39e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  499 KQQRIETLERYLADlptledhQKQSQQLKDSELKSTELQEKVtELESLLEE--------TQAICRDRETQLESLrQREAE 570
Cdd:pfam05667 241 RKRKRTKLLKRIAE-------QLRSAALAGTEATSGASRSAQ-DLAELLSSfsgssttdTGLTKGSRFTHTEKL-QFTNE 311

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  571 FSSAGHSLQDKQSVEETSGEGPEVEMESWQKQYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDS 650
Cdd:pfam05667 312 APAATSSPPTKVETEEELQQQREEELEELQEQLEDLESSIQELEKEIKKLESSIKQVEEELEELKEQNEELEKQYKVKKK 391


                  ....*...
gi 966915597  651 ALQQLRTA 658
Cdd:pfam05667 392 TLDLLPDA 399

BicD

pfam09730

Microtubule-associated protein Bicaudal-D; BicD proteins consist of three coiled-coiled ...

493-670

8.56e-03

Microtubule-associated protein Bicaudal-D; BicD proteins consist of three coiled-coiled domains and are involved in dynein-mediated minus end-directed transport from the Golgi apparatus to the endoplasmic reticulum (ER). For full functioning they bind with GSK-3beta pfam05350 to maintain the anchoring of microtubules to the centromere. It appears that amino-acid residues 437-617 of BicD and the kinase activity of GSK-3 are necessary for the formation of a complex between BicD and GSK-3beta in intact cells.

Pssm-ID: 462863 [Multi-domain] Cd Length: 717 Bit Score: 39.46 E-value: 8.56e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  493 SEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSelkSTELQEKVTELESLLEETQAICRDRETQLESLRQREAEFS 572
Cdd:pfam09730 265 SEIQKLKQQLIQVEREKVSLLSTLQESQKQLEQAKGA---LSEQQEKVNRLTENLEAMRGLQASKERQDALDSEKDRDSH 341

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  573 SAGHS----------LQDKQSVEETSGEGPEVEMESWQKQYdslQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALR 642
Cdd:pfam09730 342 EDGDYyevdingpeiLECKYRVAVEEAGELREELKALKARY---NTLEERYKEEKTRWEAEAQDLAEKIRQLEKASHQDQ 418

                         170       180       190
                  ....*....|....*....|....*....|..
gi 966915597  643 EEAQRRDSALQQLRTAVKE----LSVQNQDLI 670
Cdd:pfam09730 419 ERIAHLEKELGKTRKVAGEsegsLSVAQDELV 450

PRK11281

mechanosensitive channel MscK;

511-788

8.65e-03

mechanosensitive channel MscK;

Pssm-ID: 236892 [Multi-domain] Cd Length: 1113 Bit Score: 39.89 E-value: 8.65e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  511 ADLPTLEDHQKQSQQLKDSelKSTELQEKVteLESLLEETQAICRDRETQleslrqreaefssaghslqdkqsveetsge 590
Cdd:PRK11281   33 GDLPTEADVQAQLDALNKQ--KLLEAEDKL--VQQDLEQTLALLDKIDRQ------------------------------ 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  591 gpevemeswQKQYDSLQKIVEKQQQKMDQLRSQVQSL---EQEVAQEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQ 667
Cdd:PRK11281   79 ---------KEETEQLKQQLAQAPAKLRQAQAELEALkddNDEETRETLSTLSLRQLESRLAQTLDQLQNAQNDLAEYNS 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966915597  668 DLIeknlTLQEHLRQAQ---------------------PGSPPSPDTAQLALELYQELASCLQDLQavcsivTQRAQGHD 726
Cdd:PRK11281  150 QLV----SLQTQPERAQaalyansqrlqqirnllkggkVGGKALRPSQRVLLQAEQALLNAQNDLQ------RKSLEGNT 219

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966915597  727 pNLSLLLgihsqhpETQLDLqkpdvikrKLEEVQQLRRDIEDLRTTMSDRYAQdMGENCVTQ 788
Cdd:PRK11281  220 -QLQDLL-------QKQRDY--------LTARIQRLEHQLQLLQEAINSKRLT-LSEKTVQE 264

CALCOCO1