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Conserved domains on  [gi|966928338|ref|XP_014986943|]
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eukaryotic translation initiation factor 4 gamma 1 isoform X5 [Macaca mulatta]

Protein Classification

eukaryotic translation initiation factor 4 gamma( domain architecture ID 10501430)

eukaryotic translation initiation factor 4 gamma (EIF4G) plays a key functional role in the initiation of cap-dependent translation by acting as an adapter to nucleate the assembly of eIF4F complex

CATH:  1.25.40.180
Gene Ontology:  GO:0003743|GO:0031369|GO:0003723|GO:0003729|GO:0060090|GO:0006446
PubMed:  27694156|9019810|12867079|10872469
SCOP:  4000569

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MIF4G pfam02854
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ...
 727-952 5.02e-64

MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.


:

Pssm-ID: 397130  Cd Length: 203  Bit Score: 216.46  E-value: 5.02e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338   727 FRRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMAlkvpttekpTVTVNFR 806
Cdd:pfam02854    1 LKKVKGILNKLSPENFEKLIKELLKLIMSDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNL---------RNPTDFG 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338   807 KLLLNRCQKEFEKdkdddevfekkqkemdeaataeergrlKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCV 886
Cdd:pfam02854   72 IHLLNRLQEEFEK---------------------------RFELEENEQGNRRRRLGLVRFLGELYKFGLLTEKILFECL 124

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966928338   887 VKLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKII---KEKKTSSRIRFMLQDVLDLR 952
Cdd:pfam02854  125 KELLSSLtkedlkrDLFNLECLLTLLTTIGKLLENEKLPKLMDQFLDEIQKYVlskDDPKLSSRLRFMLQDLIELR 200
W2_eIF4G1_like cd11559
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar ...
 1404-1536 1.50e-57

C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins; eIF4G1 is a component of the multi-subunit eukaryotic translation initiation factor 4F, which facilitates recruitment of the mRNA to the ribosome, a rate-limiting step during translation initiation. This C-terminal domain, whose structure resembles that of a set of concatenated HEAT repeats, has been associated with binding to/recruiting the kinase Mnk1, which phosphorylates eIF4E.


:

Pssm-ID: 211397  Cd Length: 134  Bit Score: 194.81  E-value: 1.50e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338 1404 LPSEELNRQLEKLLKEGSSNQRVFDWIEANLSEQQIASNTLVRALMTAVCYSAIIFETPLRVDVAVLKARAKLLQKYLC- 1482
Cdd:cd11559     1 LPLLRVQAELLKLLQEDPNPDELYKWIKENVSPELYASPGFVRALMTAVLKYAIEEKSLPEKEKALLEKYAPLLQKYLDd 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 966928338 1483 DEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPA 1536
Cdd:cd11559    81 DEQLQLQALYALQALVHTLEFPKGLLLRFFDALYDEDVIEEEAFLKWKEDVDPA 134
MA3 pfam02847
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain ...
 1208-1320 4.45e-37

MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains.


:

Pssm-ID: 397128  Cd Length: 113  Bit Score: 135.48  E-value: 4.45e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338  1208 LEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLYE 1287
Cdd:pfam02847    1 LKRKIFLILEEYLSSGDYDEAARCLLKLGLPSQHHEVVKVLIECALEESKTYREFYGLLLERLCEFNLISTKQFEKGFWR 80

                           90       100       110
                   ....*....|....*....|....*....|...
gi 966928338  1288 ILELAEDMEIDIPHVWLYLAELVTPILQEGGVP 1320
Cdd:pfam02847   81 VLEDLEDLELDIPNAWRNLAEFVARLISDDGLP 113
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 51-536 2.23e-06

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.02  E-value: 2.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338   51 GSQVMMIPSQISYPASQGAYYIPGQGRStyvvPTQQYPVQPG--APGFYPGASPTEfgtyagAYYP-----AQGVQQFPT 123
Cdd:PHA03247 2476 GAPVYRRPAEARFPFAAGAAPDPGGGGP----PDPDAPPAPSrlAPAILPDEPVGE------PVHPrmltwIRGLEELAS 2545

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338  124 GVA--PAPVLMNQPPQIAPKRERKTIRIRdPNQGGKDITeeimsgARTASTPTPPQTGGGLEPQANGETPQVAVivrPDD 201
Cdd:PHA03247 2546 DDAgdPPPPLPPAAPPAAPDRSVPPPRPA-PRPSEPAVT------SRARRPDAPPQSARPRAPVDDRGDPRGPA---PPS 2615

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338  202 RSQGAIIADRPGLPGPEHSPSESQPSSPSPTPSPSpvlEPGSEPNLAVLSIPGDTMATIQMSVEESTP------ISRETG 275
Cdd:PHA03247 2616 PLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPE---RPRDDPAPGRVSRPRRARRLGRAAQASSPPqrprrrAARPTV 2692

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338  276 EPYRLS-----PEPTPLAEPILEVEVTLSKPVPESEFSSSPLQASTPLASHTveihePNGMV----PSEDLEPEVESSPE 346
Cdd:PHA03247 2693 GSLTSLadpppPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAV-----PAGPAtpggPARPARPPTTAGPP 2767

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338  347 LALPPACPSESP---VPIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEvTASVAPATILSATPAMAPSATSPAqeee 423
Cdd:PHA03247 2768 APAPPAAPAAGPprrLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAAL-PPAASPAGPLPPPTSAQPTAPPPP---- 2842

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338  424 meeeEEEEEEGEAGEAESEKGGE--ELLPSESTPVPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEavgdlLDAFKE 501
Cdd:PHA03247 2843 ----PGPPPPSLPLGGSVAPGGDvrRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPER-----PPQPQA 2913

                         490       500       510
                  ....*....|....*....|....*....|....*
gi 966928338  502 ANPAVPEVENQPPAGSNPGPESEGSGVPPRPEEAD 536
Cdd:PHA03247 2914 PPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTD 2948
 
Name Accession Description Interval E-value
MIF4G pfam02854
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ...
 727-952 5.02e-64

MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.


Pssm-ID: 397130  Cd Length: 203  Bit Score: 216.46  E-value: 5.02e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338   727 FRRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMAlkvpttekpTVTVNFR 806
Cdd:pfam02854    1 LKKVKGILNKLSPENFEKLIKELLKLIMSDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNL---------RNPTDFG 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338   807 KLLLNRCQKEFEKdkdddevfekkqkemdeaataeergrlKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCV 886
Cdd:pfam02854   72 IHLLNRLQEEFEK---------------------------RFELEENEQGNRRRRLGLVRFLGELYKFGLLTEKILFECL 124

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966928338   887 VKLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKII---KEKKTSSRIRFMLQDVLDLR 952
Cdd:pfam02854  125 KELLSSLtkedlkrDLFNLECLLTLLTTIGKLLENEKLPKLMDQFLDEIQKYVlskDDPKLSSRLRFMLQDLIELR 200
W2_eIF4G1_like cd11559
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar ...
 1404-1536 1.50e-57

C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins; eIF4G1 is a component of the multi-subunit eukaryotic translation initiation factor 4F, which facilitates recruitment of the mRNA to the ribosome, a rate-limiting step during translation initiation. This C-terminal domain, whose structure resembles that of a set of concatenated HEAT repeats, has been associated with binding to/recruiting the kinase Mnk1, which phosphorylates eIF4E.


Pssm-ID: 211397  Cd Length: 134  Bit Score: 194.81  E-value: 1.50e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338 1404 LPSEELNRQLEKLLKEGSSNQRVFDWIEANLSEQQIASNTLVRALMTAVCYSAIIFETPLRVDVAVLKARAKLLQKYLC- 1482
Cdd:cd11559     1 LPLLRVQAELLKLLQEDPNPDELYKWIKENVSPELYASPGFVRALMTAVLKYAIEEKSLPEKEKALLEKYAPLLQKYLDd 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 966928338 1483 DEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPA 1536
Cdd:cd11559    81 DEQLQLQALYALQALVHTLEFPKGLLLRFFDALYDEDVIEEEAFLKWKEDVDPA 134
MIF4G smart00543
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The ...
 728-955 1.74e-53

Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)


Pssm-ID: 214713  Cd Length: 200  Bit Score: 186.03  E-value: 1.74e-53
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338    728 RRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMAlKVPttekptvtvNFRK 807
Cdd:smart00543    2 KKVKGLINKLSPSNFESIIKELLKLNNSDKNLRKYILELIFEKAVEEPNFIPAYARLCALLNA-KNP---------DFGS 71

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338    808 LLLNRCQKEFEKDkdddevfekkqkemdeaataeergrlkeeLEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVV 887
Cdd:smart00543   72 LLLERLQEEFEKG-----------------------------LESEEESDKQRRLGLVRFLGELYNFQVLTSKIILELLK 122

                           170       180       190       200       210       220       230
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966928338    888 KLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIIKEKKT---SSRIRFMLQDVLDLRGSN 955
Cdd:smart00543  123 ELLNDLtkldpprSDFSVECLLSLLPTCGKDLEREKSPKLLDEILERLQDYLLKKDKtelSSRLRFMLELLIELRKNK 200
MA3 pfam02847
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain ...
 1208-1320 4.45e-37

MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains.


Pssm-ID: 397128  Cd Length: 113  Bit Score: 135.48  E-value: 4.45e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338  1208 LEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLYE 1287
Cdd:pfam02847    1 LKRKIFLILEEYLSSGDYDEAARCLLKLGLPSQHHEVVKVLIECALEESKTYREFYGLLLERLCEFNLISTKQFEKGFWR 80

                           90       100       110
                   ....*....|....*....|....*....|...
gi 966928338  1288 ILELAEDMEIDIPHVWLYLAELVTPILQEGGVP 1320
Cdd:pfam02847   81 VLEDLEDLELDIPNAWRNLAEFVARLISDDGLP 113
MA3 smart00544
Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and ...
 1208-1320 5.09e-36

Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains Ponting (TIBS) "Novel eIF4G domain homologues" in press


Pssm-ID: 214714  Cd Length: 113  Bit Score: 132.75  E-value: 5.09e-36
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338   1208 LEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLYE 1287
Cdd:smart00544    1 LKKKIFLIIEEYLSSGDTDEAVHCLLELKLPEQHHEVVKVLLTCALEEKRTYREMYSVLLSRLCQANVISTKQFEKGFWR 80

                            90       100       110
                    ....*....|....*....|....*....|...
gi 966928338   1288 ILELAEDMEIDIPHVWLYLAELVTPILQEGGVP 1320
Cdd:smart00544   81 LLEDIEDLELDIPNAWRNLAEFVARLISDGILP 113
eIF5C smart00515
Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;
1475-1558 1.24e-26

Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;


Pssm-ID: 214705  Cd Length: 83  Bit Score: 104.68  E-value: 1.24e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338   1475 KLLQKYLCDEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPAEqqGKGVALKSVTAFFKW 1554
Cdd:smart00515    2 PLLKFLAKDEEEQLELLYAIEEFCVELEKLGKLLPKILKSLYDADILEEEAILKWYEKAVSAE--GKKKVRKNAKPFVTW 79


                    ....
gi 966928338   1555 LREA 1558
Cdd:smart00515   80 LQEA 83
W2 pfam02020
eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of ...
 1487-1563 2.08e-23

eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of several translation initiation factors.


Pssm-ID: 460415  Cd Length: 76  Bit Score: 95.29  E-value: 2.08e-23
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966928338  1487 ELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPAEqQGKGVALKSVTAFFKWLREAEEESD 1563
Cdd:pfam02020    1 QVDLLLALQEFCAKLEELLKLLLKILKALYDLDIVEEEAILKWWEDVSSAE-KGMKKVRKQAKPFVEWLEEAEEESD 76
PHA03247 PHA03247
large tegument protein UL36; Provisional
 51-536 2.23e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.02  E-value: 2.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338   51 GSQVMMIPSQISYPASQGAYYIPGQGRStyvvPTQQYPVQPG--APGFYPGASPTEfgtyagAYYP-----AQGVQQFPT 123
Cdd:PHA03247 2476 GAPVYRRPAEARFPFAAGAAPDPGGGGP----PDPDAPPAPSrlAPAILPDEPVGE------PVHPrmltwIRGLEELAS 2545

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338  124 GVA--PAPVLMNQPPQIAPKRERKTIRIRdPNQGGKDITeeimsgARTASTPTPPQTGGGLEPQANGETPQVAVivrPDD 201
Cdd:PHA03247 2546 DDAgdPPPPLPPAAPPAAPDRSVPPPRPA-PRPSEPAVT------SRARRPDAPPQSARPRAPVDDRGDPRGPA---PPS 2615

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338  202 RSQGAIIADRPGLPGPEHSPSESQPSSPSPTPSPSpvlEPGSEPNLAVLSIPGDTMATIQMSVEESTP------ISRETG 275
Cdd:PHA03247 2616 PLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPE---RPRDDPAPGRVSRPRRARRLGRAAQASSPPqrprrrAARPTV 2692

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338  276 EPYRLS-----PEPTPLAEPILEVEVTLSKPVPESEFSSSPLQASTPLASHTveihePNGMV----PSEDLEPEVESSPE 346
Cdd:PHA03247 2693 GSLTSLadpppPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAV-----PAGPAtpggPARPARPPTTAGPP 2767

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338  347 LALPPACPSESP---VPIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEvTASVAPATILSATPAMAPSATSPAqeee 423
Cdd:PHA03247 2768 APAPPAAPAAGPprrLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAAL-PPAASPAGPLPPPTSAQPTAPPPP---- 2842

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338  424 meeeEEEEEEGEAGEAESEKGGE--ELLPSESTPVPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEavgdlLDAFKE 501
Cdd:PHA03247 2843 ----PGPPPPSLPLGGSVAPGGDvrRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPER-----PPQPQA 2913

                         490       500       510
                  ....*....|....*....|....*....|....*
gi 966928338  502 ANPAVPEVENQPPAGSNPGPESEGSGVPPRPEEAD 536
Cdd:PHA03247 2914 PPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTD 2948
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 107-418 1.23e-03

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 43.41  E-value: 1.23e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338   107 TYAGAYYPAQGVQQFPTGVAPAPVLMNQPPQIAPKRERKTIRIRDPNQGGKDiTEEIMSGARTA--STPTPPQTGGGLEP 184
Cdd:pfam17823  116 AAAASSSPSSAAQSLPAAIAALPSEAFSAPRAAACRANASAAPRAAIAAASA-PHAASPAPRTAasSTTAASSTTAASSA 194

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338   185 QANGETPQVAVIVRPDDRSQGAIIADRPGLpGPEHSPSESQPSSPSPTPSPSPVLEPGSepnLAVLSIPGDTMATIQMSV 264
Cdd:pfam17823  195 PTTAASSAPATLTPARGISTAATATGHPAA-GTALAAVGNSSPAAGTVTAAVGTVTPAA---LATLAAAAGTVASAAGTI 270

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338   265 EESTPISRetgepyRLSPeptplaepilevevtlSKPVPESEFSSSPLQASTPLASHTVeihepngMVPSEDlEPEVESS 344
Cdd:pfam17823  271 NMGDPHAR------RLSP----------------AKHMPSDTMARNPAAPMGAQAQGPI-------IQVSTD-QPVHNTA 320

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966928338   345 PElalppacpsESPVPIAPTAQPeellNGAPSPPAVDLSPVSEPEEQAKEVTASVAPATILSATPAMapSATSP 418
Cdd:pfam17823  321 GE---------PTPSPSNTTLEP----NTPKSVASTNLAVVTTTKAQAKEPSASPVPVLHTSMIPEV--EATSP 379
 
Name Accession Description Interval E-value
MIF4G pfam02854
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ...
 727-952 5.02e-64

MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.


Pssm-ID: 397130  Cd Length: 203  Bit Score: 216.46  E-value: 5.02e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338   727 FRRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMAlkvpttekpTVTVNFR 806
Cdd:pfam02854    1 LKKVKGILNKLSPENFEKLIKELLKLIMSDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNL---------RNPTDFG 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338   807 KLLLNRCQKEFEKdkdddevfekkqkemdeaataeergrlKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCV 886
Cdd:pfam02854   72 IHLLNRLQEEFEK---------------------------RFELEENEQGNRRRRLGLVRFLGELYKFGLLTEKILFECL 124

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966928338   887 VKLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKII---KEKKTSSRIRFMLQDVLDLR 952
Cdd:pfam02854  125 KELLSSLtkedlkrDLFNLECLLTLLTTIGKLLENEKLPKLMDQFLDEIQKYVlskDDPKLSSRLRFMLQDLIELR 200
W2_eIF4G1_like cd11559
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar ...
 1404-1536 1.50e-57

C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins; eIF4G1 is a component of the multi-subunit eukaryotic translation initiation factor 4F, which facilitates recruitment of the mRNA to the ribosome, a rate-limiting step during translation initiation. This C-terminal domain, whose structure resembles that of a set of concatenated HEAT repeats, has been associated with binding to/recruiting the kinase Mnk1, which phosphorylates eIF4E.


Pssm-ID: 211397  Cd Length: 134  Bit Score: 194.81  E-value: 1.50e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338 1404 LPSEELNRQLEKLLKEGSSNQRVFDWIEANLSEQQIASNTLVRALMTAVCYSAIIFETPLRVDVAVLKARAKLLQKYLC- 1482
Cdd:cd11559     1 LPLLRVQAELLKLLQEDPNPDELYKWIKENVSPELYASPGFVRALMTAVLKYAIEEKSLPEKEKALLEKYAPLLQKYLDd 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 966928338 1483 DEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPA 1536
Cdd:cd11559    81 DEQLQLQALYALQALVHTLEFPKGLLLRFFDALYDEDVIEEEAFLKWKEDVDPA 134
MIF4G smart00543
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The ...
 728-955 1.74e-53

Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)


Pssm-ID: 214713  Cd Length: 200  Bit Score: 186.03  E-value: 1.74e-53
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338    728 RRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMAlKVPttekptvtvNFRK 807
Cdd:smart00543    2 KKVKGLINKLSPSNFESIIKELLKLNNSDKNLRKYILELIFEKAVEEPNFIPAYARLCALLNA-KNP---------DFGS 71

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338    808 LLLNRCQKEFEKDkdddevfekkqkemdeaataeergrlkeeLEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVV 887
Cdd:smart00543   72 LLLERLQEEFEKG-----------------------------LESEEESDKQRRLGLVRFLGELYNFQVLTSKIILELLK 122

                           170       180       190       200       210       220       230
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966928338    888 KLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIIKEKKT---SSRIRFMLQDVLDLRGSN 955
Cdd:smart00543  123 ELLNDLtkldpprSDFSVECLLSLLPTCGKDLEREKSPKLLDEILERLQDYLLKKDKtelSSRLRFMLELLIELRKNK 200
MA3 pfam02847
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain ...
 1208-1320 4.45e-37

MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains.


Pssm-ID: 397128  Cd Length: 113  Bit Score: 135.48  E-value: 4.45e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338  1208 LEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLYE 1287
Cdd:pfam02847    1 LKRKIFLILEEYLSSGDYDEAARCLLKLGLPSQHHEVVKVLIECALEESKTYREFYGLLLERLCEFNLISTKQFEKGFWR 80

                           90       100       110
                   ....*....|....*....|....*....|...
gi 966928338  1288 ILELAEDMEIDIPHVWLYLAELVTPILQEGGVP 1320
Cdd:pfam02847   81 VLEDLEDLELDIPNAWRNLAEFVARLISDDGLP 113
MA3 smart00544
Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and ...
 1208-1320 5.09e-36

Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains Ponting (TIBS) "Novel eIF4G domain homologues" in press


Pssm-ID: 214714  Cd Length: 113  Bit Score: 132.75  E-value: 5.09e-36
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338   1208 LEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLYE 1287
Cdd:smart00544    1 LKKKIFLIIEEYLSSGDTDEAVHCLLELKLPEQHHEVVKVLLTCALEEKRTYREMYSVLLSRLCQANVISTKQFEKGFWR 80

                            90       100       110
                    ....*....|....*....|....*....|...
gi 966928338   1288 ILELAEDMEIDIPHVWLYLAELVTPILQEGGVP 1320
Cdd:smart00544   81 LLEDIEDLELDIPNAWRNLAEFVARLISDGILP 113
eIF5C smart00515
Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;
1475-1558 1.24e-26

Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;


Pssm-ID: 214705  Cd Length: 83  Bit Score: 104.68  E-value: 1.24e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338   1475 KLLQKYLCDEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPAEqqGKGVALKSVTAFFKW 1554
Cdd:smart00515    2 PLLKFLAKDEEEQLELLYAIEEFCVELEKLGKLLPKILKSLYDADILEEEAILKWYEKAVSAE--GKKKVRKNAKPFVTW 79


                    ....
gi 966928338   1555 LREA 1558
Cdd:smart00515   80 LQEA 83
W2 pfam02020
eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of ...
 1487-1563 2.08e-23

eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of several translation initiation factors.


Pssm-ID: 460415  Cd Length: 76  Bit Score: 95.29  E-value: 2.08e-23
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966928338  1487 ELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPAEqQGKGVALKSVTAFFKWLREAEEESD 1563
Cdd:pfam02020    1 QVDLLLALQEFCAKLEELLKLLLKILKALYDLDIVEEEAILKWWEDVSSAE-KGMKKVRKQAKPFVEWLEEAEEESD 76
W2 cd11473
C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon; This domain is found at the C-terminus of ...
 1405-1530 3.60e-23

C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon; This domain is found at the C-terminus of several translation initiation factors, including the epsilon chain of eIF2b, where it has been found to catalyze the conversion of eIF2.GDP to its active eIF2.GTP form. The structure of the domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211395  Cd Length: 135  Bit Score: 96.78  E-value: 3.60e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338 1405 PSEELNRQLEKLLKEG-SSNQRVFDWIEANLSEQQIASNTLVRALMTAVCYSAIIFE----TPLRVDVAVLKARAKLLQK 1479
Cdd:cd11473     2 KNKKLRDSLLKELEEDkSSDVESVKAAKSKLDLDPISLEEVVKVLLTAVVNAVESADsislTQKEQLVLVLKKYGPVLRE 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 966928338 1480 YLCD-EQKELQALYALQALVVT--LEQPPNLLRMFFDALYDEDVVKEDAFYSWE 1530
Cdd:cd11473    82 LLKLiKKDQLYLLLKIEKLCLQlkLSELISLLEKILDLLYDADVLSEEAILSWF 135
W2_eIF2B_epsilon cd11558
C-terminal W2 domain of eukaryotic translation initiation factor 2B epsilon; eIF2B is a ...
 1433-1563 1.62e-15

C-terminal W2 domain of eukaryotic translation initiation factor 2B epsilon; eIF2B is a heteropentameric complex which functions as a guanine nucleotide exchange factor in the recycling of eIF-2 during the initiation of translation in eukaryotes. The epsilon and gamma subunits are sequence similar and both are essential in yeast. Epsilon appears to be the catalytically active subunit, with gamma enhancing its activity. The C-terminal domain of the eIF2B epsilon subunit contains bipartite motifs rich in acidic and aromatic residues, which are responsible for the interaction with eIF2. The structure of the domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211396  Cd Length: 169  Bit Score: 75.76  E-value: 1.62e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338 1433 NLSEQQIASNTlVRALMTAVCYSAIIFETPLRVDVAVLKARAK-LLQKYLCDEQKELQALYALQALVVTLEQPPNLLRMF 1511
Cdd:cd11558    39 NVTDHDVRRAV-VKALLELILEVSSTSTAELLEALKKLLSKWGpLLENYVKSQDDQVELLLALEEFCLESEEGGPLFAKL 117

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 966928338 1512 FDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFKWLREAEEESD 1563
Cdd:cd11558   118 LHALYDLDILEEEAILEWWEEPDAGADEEMKKVRELVKKFIEWLEEAEEESD 169
W2_eIF5 cd11561
C-terminal W2 domain of eukaryotic translation initiation factor 5; eIF5 functions as a GTPase ...
 1405-1563 2.46e-09

C-terminal W2 domain of eukaryotic translation initiation factor 5; eIF5 functions as a GTPase acceleration protein (GAP), as well as a GDP dissociation inhibitor (GDI) during translational initiation in eukaryotes. The structure of this C-terminal domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211399  Cd Length: 157  Bit Score: 57.63  E-value: 2.46e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338 1405 PSEELNR--QLEKLLKEGSSNQRVFDwIEANLSEQQIASNTLVRALmtavcysAIIFETPLRVD-VAVLKARAKLLQKYL 1481
Cdd:cd11561     1 EEEEDERvdELGEFLKKNKDESGLSE-LKEILKEAERLDVVKDKAV-------LVLAEVLFDENiVKEIKKRKALLLKLV 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338 1482 CDEQKELQALYALQALVVtlEQPPNLLRMF---FDALYDEDVVKEDAFYSW---ESSKDPAEQQGKGVaLKSVTAFFKWL 1555
Cdd:cd11561    73 TDEKAQKALLGGIERFCG--KHSPELLKKVpliLKALYDNDILEEEVILKWyekVSKKYVSKEKSKKV-RKAAEPFVEWL 149


                  ....*...
gi 966928338 1556 REAEEESD 1563
Cdd:cd11561   150 EEAEEEEE 157
W2_eIF5C_like cd11560
C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; ...
 1401-1561 7.66e-08

C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; eIF5C appears to be essential for the initiation of protein translation; its actual function, and specifically that of the C-terminal W2 domain, are not well understood. The Drosophila ortholog, kra (krasavietz) or exba (extra bases), may be involved in translational inhibition in neural development. The structure of this C-terminal domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211398 [Multi-domain]  Cd Length: 194  Bit Score: 54.14  E-value: 7.66e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338 1401 QRALPSEELNRQLEKLLKEGSSNQRVFDWIEANLSEQQIASN--------TLVRALMTAVCYSA---IIFETPLRVdvav 1469
Cdd:cd11560    29 YRKQASQEIKKELQQELKEMIAEEEPVKEIIAAVKEQMKKSSlpehevvgLLWTALMDAVEWSKkedQIAEQALRH---- 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338 1470 LKARAKLLQKYLCDEQKELQALYALQalVVTLEQPpNLLRMFFD---ALYDEDVVKEDAFYSWesSKDPAEQQGKGVALK 1546
Cdd:cd11560   105 LKKYAPLLAAFCTTARAELALLNKIQ--EYCYENM-KFMKVFQKivkLLYKADVLSEDAILKW--YKKGHSPKGKQVFLK 179

                         170
                  ....*....|....*
gi 966928338 1547 SVTAFFKWLREAEEE 1561
Cdd:cd11560   180 QMEPFVEWLQEAEEE 194
PHA03247 PHA03247
large tegument protein UL36; Provisional
 51-536 2.23e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.02  E-value: 2.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338   51 GSQVMMIPSQISYPASQGAYYIPGQGRStyvvPTQQYPVQPG--APGFYPGASPTEfgtyagAYYP-----AQGVQQFPT 123
Cdd:PHA03247 2476 GAPVYRRPAEARFPFAAGAAPDPGGGGP----PDPDAPPAPSrlAPAILPDEPVGE------PVHPrmltwIRGLEELAS 2545

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338  124 GVA--PAPVLMNQPPQIAPKRERKTIRIRdPNQGGKDITeeimsgARTASTPTPPQTGGGLEPQANGETPQVAVivrPDD 201
Cdd:PHA03247 2546 DDAgdPPPPLPPAAPPAAPDRSVPPPRPA-PRPSEPAVT------SRARRPDAPPQSARPRAPVDDRGDPRGPA---PPS 2615

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338  202 RSQGAIIADRPGLPGPEHSPSESQPSSPSPTPSPSpvlEPGSEPNLAVLSIPGDTMATIQMSVEESTP------ISRETG 275
Cdd:PHA03247 2616 PLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPE---RPRDDPAPGRVSRPRRARRLGRAAQASSPPqrprrrAARPTV 2692

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338  276 EPYRLS-----PEPTPLAEPILEVEVTLSKPVPESEFSSSPLQASTPLASHTveihePNGMV----PSEDLEPEVESSPE 346
Cdd:PHA03247 2693 GSLTSLadpppPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAV-----PAGPAtpggPARPARPPTTAGPP 2767

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338  347 LALPPACPSESP---VPIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEvTASVAPATILSATPAMAPSATSPAqeee 423
Cdd:PHA03247 2768 APAPPAAPAAGPprrLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAAL-PPAASPAGPLPPPTSAQPTAPPPP---- 2842

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338  424 meeeEEEEEEGEAGEAESEKGGE--ELLPSESTPVPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEavgdlLDAFKE 501
Cdd:PHA03247 2843 ----PGPPPPSLPLGGSVAPGGDvrRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPER-----PPQPQA 2913

                         490       500       510
                  ....*....|....*....|....*....|....*
gi 966928338  502 ANPAVPEVENQPPAGSNPGPESEGSGVPPRPEEAD 536
Cdd:PHA03247 2914 PPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTD 2948
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
243-529 8.15e-06

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 50.62  E-value: 8.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338  243 SEPNLAVLSIPGDTMATIQMSVEE------STPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAST 316
Cdd:PRK07003  336 GELGLAPDEYAGFTMTLLRMLAFEpavtggGAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAA 415

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338  317 PLASHTVEIHEPNGMVPSEDLEPEVESSPElalPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVS--------EP 388
Cdd:PRK07003  416 AAAAATRAEAPPAAPAPPATADRGDDAADG---DAPVPAKANARASADSRCDERDAQPPADSGSASAPASdappdaafEP 492

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338  389 EEQAKEVTASVAPATILSATPAMAPSATSPAQEEEMEEEEEEEEEGEAGEAESEKGGEELL----------------PSE 452
Cdd:PRK07003  493 APRAAAPSAATPAAVPDARAPAAASREDAPAAAAPPAPEARPPTPAAAAPAARAGGAAAALdvlrnagmrvssdrgaRAA 572

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966928338  453 STPVPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAFKEANPAVPEVENQPPAGSNPGPESEGSGVP 529
Cdd:PRK07003  573 AAAKPAAAPAAAPKPAAPRVAVQVPTPRARAATGDAPPNGAARAEQAAESRGAPPPWEDIPPDDYVPLSADEGFGGP 649
PHA03247 PHA03247
large tegument protein UL36; Provisional
 20-530 2.55e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.17  E-value: 2.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338   20 PSRAQPPSSAASRvqsaaparpgpaahvyPAGSQVMMIPSQISYPASQGAYYIPGQGRSTYVVPTQQYPVQPGAPGFYPG 99
Cdd:PHA03247 2564 PDRSVPPPRPAPR----------------PSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPP 2627

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338  100 A-SPTEFGTYAGAYYPAQGVQQFPTGVAPAP---------VLMNQPPQIAPKRERKTIRIRDPNQGG---------KDIT 160
Cdd:PHA03247 2628 PpSPSPAANEPDPHPPPTVPPPERPRDDPAPgrvsrprraRRLGRAAQASSPPQRPRRRAARPTVGSltsladpppPPPT 2707

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338  161 EEIMSGARTASTPTP--PQTGGGLEPQANGETPQVAVIVRPDDRSQGAIIADRPGLPGPEHSPSESQPSSPSPTPSPSPV 238
Cdd:PHA03247 2708 PEPAPHALVSATPLPpgPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPA 2787

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338  239 LEPGSE--PNLAVLSIPGDTMATIQMSVEESTPISR-ETGEPYRLSPEPTPLAEPILEVEVTLS---KPVPESEFSSSPL 312
Cdd:PHA03247 2788 VASLSEsrESLPSPWDPADPPAAVLAPAAALPPAASpAGPLPPPTSAQPTAPPPPPGPPPPSLPlggSVAPGGDVRRRPP 2867

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338  313 QASTPlASHTVEIHEPNGMVPSEDLEPEVESSPELALPPACPSESPVPIAPTAQPEELLNGAPSP-------PAVDLSPV 385
Cdd:PHA03247 2868 SRSPA-AKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPpppppprPQPPLAPT 2946

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338  386 SEPEEQAKEVTASVAP---ATILSATPAMAPSATSPAQEEEMEEEEEEEEEGEAGEAESEKGGEELLPSESTPVPANLSQ 462
Cdd:PHA03247 2947 TDPAGAGEPSGAVPQPwlgALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSLALHEETDPPPVSLKQ 3026

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966928338  463 NL------EAAAATQVAVSVPKRrrkikelNKKEAVgDLLDAFKEANPAVPEVENQPPAGSNPGPESEgSGVPP 530
Cdd:PHA03247 3027 TLwppddtEDSDADSLFDSDSER-------SDLEAL-DPLPPEPHDPFAHEPDPATPEAGARESPSSQ-FGPPP 3091
rne PRK10811
ribonuclease E; Reviewed
 267-420 7.02e-04

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 44.26  E-value: 7.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338  267 STPISR-ETGEPYRLSPEPTPLAEPILeVEVTLSKPVPESEfSSSPLQASTPLASHTVEIHEPN--GMVPSEDLEPEVES 343
Cdd:PRK10811  844 RYPVVRpQDVQVEEQREAEEVQVQPVV-AEVPVAAAVEPVV-SAPVVEAVAEVVEEPVVVAEPQpeEVVVVETTHPEVIA 921

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338  344 SPELALPP-------ACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASVAPATILSATPAMAPSAT 416
Cdd:PRK10811  922 APVTEQPQvitesdvAVAQEVAEHAEPVVEPQDETADIEEAAETAEVVVAEPEVVAQPAAPVVAEVAAEVETVTAVEPEV 1001


                  ....
gi 966928338  417 SPAQ 420
Cdd:PRK10811 1002 APAQ 1005
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
372-538 8.14e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 44.10  E-value: 8.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338  372 NGAPSPPAVDLSPVSEPEEQAKEVTASVAPATILSATPAMAPS----ATSPAQEEEMEEEEEEEEEGEAGEAESEKGGEE 447
Cdd:PRK12323  369 GGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAaaaaARAVAAAPARRSPAPEALAAARQASARGPGGAP 448

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338  448 LLPSESTPVPANLSQNLEAAAATQVAVSVPKRRRKIKElNKKEAVGDLLDAFKEANPAVPEVenqPPAGSNPGPESEGSG 527
Cdd:PRK12323  449 APAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPA-AAPAPADDDPPPWEELPPEFASP---APAQPDAAPAGWVAE 524

                         170
                  ....*....|.
gi 966928338  528 VPPRPEEADET 538
Cdd:PRK12323  525 SIPDPATADPD 535
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 107-418 1.23e-03

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 43.41  E-value: 1.23e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338   107 TYAGAYYPAQGVQQFPTGVAPAPVLMNQPPQIAPKRERKTIRIRDPNQGGKDiTEEIMSGARTA--STPTPPQTGGGLEP 184
Cdd:pfam17823  116 AAAASSSPSSAAQSLPAAIAALPSEAFSAPRAAACRANASAAPRAAIAAASA-PHAASPAPRTAasSTTAASSTTAASSA 194

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338   185 QANGETPQVAVIVRPDDRSQGAIIADRPGLpGPEHSPSESQPSSPSPTPSPSPVLEPGSepnLAVLSIPGDTMATIQMSV 264
Cdd:pfam17823  195 PTTAASSAPATLTPARGISTAATATGHPAA-GTALAAVGNSSPAAGTVTAAVGTVTPAA---LATLAAAAGTVASAAGTI 270

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338   265 EESTPISRetgepyRLSPeptplaepilevevtlSKPVPESEFSSSPLQASTPLASHTVeihepngMVPSEDlEPEVESS 344
Cdd:pfam17823  271 NMGDPHAR------RLSP----------------AKHMPSDTMARNPAAPMGAQAQGPI-------IQVSTD-QPVHNTA 320

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966928338   345 PElalppacpsESPVPIAPTAQPeellNGAPSPPAVDLSPVSEPEEQAKEVTASVAPATILSATPAMapSATSP 418
Cdd:pfam17823  321 GE---------PTPSPSNTTLEP----NTPKSVASTNLAVVTTTKAQAKEPSASPVPVLHTSMIPEV--EATSP 379
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 151-415 1.79e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 43.15  E-value: 1.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338  151 DPNQGGKDITEEIMSGARTAS------------TPTPPQTGgglePQANGETPQVAVIVRPDDRSQGAIIADRP------ 212
Cdd:PRK10263  308 DPLLNGAPITEPVAVAAAATTatqswaapvepvTQTPPVAS----VDVPPAQPTVAWQPVPGPQTGEPVIAPAPegypqq 383

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338  213 ---GLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMATIQMSVEESTPISRETGEPyrlsPEPTPLAE 289
Cdd:PRK10263  384 sqyAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEE----QQSTFAPQ 459

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338  290 PILEVEVTLSKPVPESEFSSSPLQASTPLASHTV-EIHEPNGMVPSEDLEPEVESS-----PELAL---PPACPSESPVP 360
Cdd:PRK10263  460 STYQTEQTYQQPAAQEPLYQQPQPVEQQPVVEPEpVVEETKPARPPLYYFEEVEEKrarerEQLAAwyqPIPEPVKEPEP 539

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 966928338  361 IAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAkevtASVAPATILSATPAMAPSA 415
Cdd:PRK10263  540 IKSSLKAPSVAAVPPVEAAAAVSPLASGVKKA----TLATGAAATVAAPVFSLAN 590
TALPID3 pfam15324
Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for ...
 254-389 3.88e-03

Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for Hedgehog signalling. Mutations in this gene noticed first in chickens lead to multiple abnormalities of development.


Pssm-ID: 434634 [Multi-domain]  Cd Length: 1288  Bit Score: 42.18  E-value: 3.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338   254 GDTMATIQMSVEESTPISRETGEPYRLSPEPTPLAEPilevevTLSKPVPESEfsssPLQASTPLASHTVEIHEpngMVP 333
Cdd:pfam15324  959 GDREAQREPPVAASVPGDLPTKETLLPTPVPTPQPTP------PCSPPSPLKE----PSPVKTPDSSPCVSEHD---FFP 1025

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 966928338   334 SEDLEPEVESSPELALPPA-CPSESPVPIAPTAqpeellnGAPSPP----AVDLSPVSEPE 389
Cdd:pfam15324 1026 VKEIPPEKGADTGPAVSLViTPTVTPIATPPPA-------ATPTPPlsenSIDKLKSPSPE 1079
PHA03325 PHA03325
nuclear-egress-membrane-like protein; Provisional
 258-418 5.73e-03

nuclear-egress-membrane-like protein; Provisional


Pssm-ID: 223044  Cd Length: 418  Bit Score: 41.02  E-value: 5.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338  258 ATIQMSVEESTPISRETG-EPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQASTplashtveihepnGMVPSED 336
Cdd:PHA03325  262 FMLNSSLPTSAPKRRSRRaGAMRAAAGETADLADDDGSEHSDPEPLPASLPPPPVRRPRV-------------KHPEAGK 328

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928338  337 LEPEVESSPElALPPACPSESP-VPIAPTAQPEEllnGAPSPPAVDLSPVSEPEEQAKEVTASVAPATILSATPaMAPSA 415
Cdd:PHA03325  329 EEPDGARNAE-AKEPAQPATSTsSKGSSSAQNKD---SGSTGPGSSLAAASSFLEDDDFGSPPLDLTTSLRHMP-SPSVT 403


                  ...
gi 966928338  416 TSP 418
Cdd:PHA03325  404 SAP 406
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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