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Conserved domains on  [gi|1622824917|ref|XP_014986438|]
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inactive polyglycylase TTLL10 isoform X1 [Macaca mulatta]

Protein Classification

ATP-grasp domain-containing protein( domain architecture ID 106900)

ATP-grasp domain-containing protein may be related to carbamoyl phosphate synthetase and predicted to be involved in the biosynthesis of a ribonucleoside involved in stress response

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CPSase_L_D2 super family cl17255
Carbamoyl-phosphate synthase L chain, ATP binding domain; Carbamoyl-phosphate synthase ...
 381-636 8.80e-45

Carbamoyl-phosphate synthase L chain, ATP binding domain; Carbamoyl-phosphate synthase catalyzes the ATP-dependent synthesis of carbamyl-phosphate from glutamine or ammonia and bicarbonate. This important enzyme initiates both the urea cycle and the biosynthesis of arginine and/or pyrimidines. The carbamoyl-phosphate synthase (CPS) enzyme in prokaryotes is a heterodimer of a small and large chain. The small chain promotes the hydrolysis of glutamine to ammonia, which is used by the large chain to synthesize carbamoyl phosphate. See pfam00988. The small chain has a GATase domain in the carboxyl terminus. See pfam00117. The ATP binding domain (this one) has an ATP-grasp fold.


The actual alignment was detected with superfamily member pfam03133:

Pssm-ID: 473076  Cd Length: 291  Bit Score: 162.89  E-value: 8.80e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917 381 EEFFPETYRLDLkhEREAFFTLF--DETQIWICKPTASNQGKGIFLlrkqeevaalqakTRSAEDDPIHHKSpfrgpQAR 458
Cdd:pfam03133  41 GDFLPRTFILPT--DLAEFVDYFedRERNTWIVKPSASARGRGIRV-------------TNKLSQIPKWSQS-----RPL 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917 459 VVQRYIQNPLLLDGRKFDVRSYLLIACTTPYMIF-FSHGYARLTLSLYDPHSSDLSG---HLTNQFMQKKSPL---YVLL 531
Cdd:pfam03133 101 VVQKYIERPLLIDGRKFDIRLYVLVTSVNPLRVYvYREGLLRFASVKYSPSSSDLDDvemHLTNYSIQKKSSSlneDYNE 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917 532 KEDTVWSMERLNRYInttfwkaRGLPKDWVFTTLTK-RMQQIMAHCFLAAKSKLECKLGYFDLIGCDFLIDDNFKVWLLE 610
Cdd:pfam03133 181 PHGHKWSLQNFWKYL-------EEKDKDEIWLEIESiIIKTILAAEVEASRLNVQPLPNCFELYGFDFMIDENLKPWLLE 253

                         250       260
                  ....*....|....*....|....*.
gi 1622824917 611 MNSNPALHTNCEVLKEVIPGVVIETL 636
Cdd:pfam03133 254 VNSSPSLHSTTKLDARLKEQLIDDVL 279
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 26-256 1.83e-07

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 55.33  E-value: 1.83e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917   26 PGRARPR-PRSSSGrgglARQRQGAETASAPHGAKPHGCHGGRSQPPTEAQVHGPGRRPFLGRVGLTACPIQVLGPRAAR 104
Cdd:PHA03247  2593 PQSARPRaPVDDRG----DPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRAR 2668

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917  105 SSHRRVKAASSLQGPRPGAPRPMAHSCTRFVHRRGPPtrtqagskrgkrPKIQRRPRARVPG-PAHERPMGSSQEE-GLP 182
Cdd:PHA03247  2669 RLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPP------------PTPEPAPHALVSAtPLPPGPAAARQASpALP 2736

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622824917  183 CQPSQPDHDTGGHGGLDLEGAGRVSTTPGPPGLLTSHPPADSDDTDATGPPAALLEGLLLGDGKPSPHSTRPGP 256
Cdd:PHA03247  2737 AAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAA 2810
PRK07764 super family cl35613
DNA polymerase III subunits gamma and tau; Validated
 686-791 3.13e-06

DNA polymerase III subunits gamma and tau; Validated


The actual alignment was detected with superfamily member PRK07764:

Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 50.75  E-value: 3.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917 686 PPPTRQAKSSGPPTPRAPDQPGTRRPVPPPLAPQRPQlPGPSPDPDSAHDGQPQAPGKEQSGTGDRHPEQEPSP---GTA 762
Cdd:PRK07764  394 PAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQ-PAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPapaPAA 472

                          90       100
                  ....*....|....*....|....*....
gi 1622824917 763 KEERKEPENARPWGGHPRPTPHAPATLPA 791
Cdd:PRK07764  473 APEPTAAPAPAPPAAPAPAAAPAAPAAPA 501
 
Name Accession Description Interval E-value
TTL pfam03133
Tubulin-tyrosine ligase family; Tubulins and microtubules are subjected to several ...
 381-636 8.80e-45

Tubulin-tyrosine ligase family; Tubulins and microtubules are subjected to several post-translational modifications of which the reversible detyrosination/tyrosination of the carboxy-terminal end of most alpha-tubulins has been extensively analysed. This modification cycle involves a specific carboxypeptidase and the activity of the tubulin-tyrosine ligase (TTL). The true physiological function of TTL has so far not been established. Tubulin-tyrosine ligase (TTL) catalyzes the ATP-dependent post-translational addition of a tyrosine to the carboxy terminal end of detyrosinated alpha-tubulin. In normally cycling cells, the tyrosinated form of tubulin predominates. However, in breast cancer cells, the detyrosinated form frequently predominates, with a correlation to tumour aggressiveness. On the other hand, 3-nitrotyrosine has been shown to be incorporated, by TTL, into the carboxy terminal end of detyrosinated alpha-tubulin. This reaction is not reversible by the carboxypeptidase enzyme. Cells cultured in 3-nitrotyrosine rich medium showed evidence of altered microtubule structure and function, including altered cell morphology, epithelial barrier dysfunction, and apoptosis. Bacterial homologs of TTL are predicted to form peptide tags. Some of these are fused to a 2-oxoglutarate Fe(II)-dependent dioxygenase domain.


Pssm-ID: 397308  Cd Length: 291  Bit Score: 162.89  E-value: 8.80e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917 381 EEFFPETYRLDLkhEREAFFTLF--DETQIWICKPTASNQGKGIFLlrkqeevaalqakTRSAEDDPIHHKSpfrgpQAR 458
Cdd:pfam03133  41 GDFLPRTFILPT--DLAEFVDYFedRERNTWIVKPSASARGRGIRV-------------TNKLSQIPKWSQS-----RPL 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917 459 VVQRYIQNPLLLDGRKFDVRSYLLIACTTPYMIF-FSHGYARLTLSLYDPHSSDLSG---HLTNQFMQKKSPL---YVLL 531
Cdd:pfam03133 101 VVQKYIERPLLIDGRKFDIRLYVLVTSVNPLRVYvYREGLLRFASVKYSPSSSDLDDvemHLTNYSIQKKSSSlneDYNE 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917 532 KEDTVWSMERLNRYInttfwkaRGLPKDWVFTTLTK-RMQQIMAHCFLAAKSKLECKLGYFDLIGCDFLIDDNFKVWLLE 610
Cdd:pfam03133 181 PHGHKWSLQNFWKYL-------EEKDKDEIWLEIESiIIKTILAAEVEASRLNVQPLPNCFELYGFDFMIDENLKPWLLE 253

                         250       260
                  ....*....|....*....|....*.
gi 1622824917 611 MNSNPALHTNCEVLKEVIPGVVIETL 636
Cdd:pfam03133 254 VNSSPSLHSTTKLDARLKEQLIDDVL 279
PHA03247 PHA03247
large tegument protein UL36; Provisional
 26-256 1.83e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 55.33  E-value: 1.83e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917   26 PGRARPR-PRSSSGrgglARQRQGAETASAPHGAKPHGCHGGRSQPPTEAQVHGPGRRPFLGRVGLTACPIQVLGPRAAR 104
Cdd:PHA03247  2593 PQSARPRaPVDDRG----DPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRAR 2668

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917  105 SSHRRVKAASSLQGPRPGAPRPMAHSCTRFVHRRGPPtrtqagskrgkrPKIQRRPRARVPG-PAHERPMGSSQEE-GLP 182
Cdd:PHA03247  2669 RLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPP------------PTPEPAPHALVSAtPLPPGPAAARQASpALP 2736

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622824917  183 CQPSQPDHDTGGHGGLDLEGAGRVSTTPGPPGLLTSHPPADSDDTDATGPPAALLEGLLLGDGKPSPHSTRPGP 256
Cdd:PHA03247  2737 AAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAA 2810
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 686-791 3.13e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 50.75  E-value: 3.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917 686 PPPTRQAKSSGPPTPRAPDQPGTRRPVPPPLAPQRPQlPGPSPDPDSAHDGQPQAPGKEQSGTGDRHPEQEPSP---GTA 762
Cdd:PRK07764  394 PAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQ-PAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPapaPAA 472

                          90       100
                  ....*....|....*....|....*....
gi 1622824917 763 KEERKEPENARPWGGHPRPTPHAPATLPA 791
Cdd:PRK07764  473 APEPTAAPAPAPPAAPAPAAAPAAPAAPA 501
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 687-786 2.36e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 41.68  E-value: 2.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917 687 PPTRQAKSSGPPTPRAPDQPGTR--RPVPPPLAPQRPQLPGPSPDPDSAHDGQPQAPGKEQSGTGDRHPEQEPSPGTAKE 764
Cdd:pfam03154 171 PPVLQAQSGAASPPSPPPPGTTQaaTAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPLQ 250

                          90       100
                  ....*....|....*....|....
gi 1622824917 765 ERKE--PENARPWGGHPRPTPHAP 786
Cdd:pfam03154 251 PMTQppPPSQVSPQPLPQPSLHGQ 274
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 686-794 2.94e-03

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 40.52  E-value: 2.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917 686 PPPTRQAKSSGPPTPRAPDQPGTRRPV--PPPLAPQRPQLPGPSPDPDSAHDGQPQAPGKEQSGTGDRHPEQEPSPGTAK 763
Cdd:NF040712  226 APATDSDPAEAGTPDDLASARRRRAGVeqPEDEPVGPGAAPAAEPDEATRDAGEPPAPGAAETPEAAEPPAPAPAAPAAP 305

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1622824917 764 EERKEPENARPwGGHPRPTPHAP---ATLPAFRD 794
Cdd:NF040712  306 AAPEAEEPARP-EPPPAPKPKRRrrrASVPSWDD 338
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 689-790 3.72e-03

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 40.52  E-value: 3.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917 689 TRQAKSSGPPTPRAPDQPGTRRPVP-------PPLAPQRPQLPGPSPDPDSahdgQPQAPGKEQSGTGDR-HPEQEPSPG 760
Cdd:NF033839  273 TKFKKGLTQDTPKEPGNKKPSAPKPgmqpspqPEKKEVKPEPETPKPEVKP----QLEKPKPEVKPQPEKpKPEVKPQLE 348

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1622824917 761 TAKEE-RKEPENARPwGGHPRPTPHAPATLP 790
Cdd:NF033839  349 TPKPEvKPQPEKPKP-EVKPQPEKPKPEVKP 378
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 698-788 6.66e-03

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 39.75  E-value: 6.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917 698 PTPRAPDQPGTRRP-VPPPLAPQRPQLPGPSPDPDSAHDGQPQAPGKE---QSGTGDrhPEQEPSPGTAKEERK-EPENA 772
Cdd:NF033839  405 PKPEVKPQPEKPKPeVKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPEvkpQPETPK--PEVKPQPEKPKPEVKpQPEKP 482

                          90
                  ....*....|....*.
gi 1622824917 773 RPWGGHPRPTPHAPAT 788
Cdd:NF033839  483 KPDNSKPQADDKKPST 498
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 698-790 7.38e-03

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 39.75  E-value: 7.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917 698 PTPRAPDQPGTRRPV--PPPLAPQ---RPQLPGPSPD-------PDSAHDGQPQAPgkeqsgtgdrHPEQEPSPGTAKEE 765
Cdd:NF033839  339 PKPEVKPQLETPKPEvkPQPEKPKpevKPQPEKPKPEvkpqpetPKPEVKPQPEKP----------KPEVKPQPEKPKPE 408

                          90       100
                  ....*....|....*....|....*.
gi 1622824917 766 RK-EPENARPwGGHPRPTPHAPATLP 790
Cdd:NF033839  409 VKpQPEKPKP-EVKPQPEKPKPEVKP 433
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 682-792 8.67e-03

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 39.37  E-value: 8.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917 682 RRRLPPPTRQAkssgpPTPRAPDQPGTRRPVPPPLAPQRPQLPGPSPDPDSAHDGQPQAPGKEQSGTGDRHPEQEPSPGT 761
Cdd:NF040712  196 LRPLATVPRLA-----REPADARPEEVEPAPAAEGAPATDSDPAEAGTPDDLASARRRRAGVEQPEDEPVGPGAAPAAEP 270

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1622824917 762 AKEERKEPENARPWGGHPRPTPHAPATLPAF 792
Cdd:NF040712  271 DEATRDAGEPPAPGAAETPEAAEPPAPAPAA 301
 
Name Accession Description Interval E-value
TTL pfam03133
Tubulin-tyrosine ligase family; Tubulins and microtubules are subjected to several ...
 381-636 8.80e-45

Tubulin-tyrosine ligase family; Tubulins and microtubules are subjected to several post-translational modifications of which the reversible detyrosination/tyrosination of the carboxy-terminal end of most alpha-tubulins has been extensively analysed. This modification cycle involves a specific carboxypeptidase and the activity of the tubulin-tyrosine ligase (TTL). The true physiological function of TTL has so far not been established. Tubulin-tyrosine ligase (TTL) catalyzes the ATP-dependent post-translational addition of a tyrosine to the carboxy terminal end of detyrosinated alpha-tubulin. In normally cycling cells, the tyrosinated form of tubulin predominates. However, in breast cancer cells, the detyrosinated form frequently predominates, with a correlation to tumour aggressiveness. On the other hand, 3-nitrotyrosine has been shown to be incorporated, by TTL, into the carboxy terminal end of detyrosinated alpha-tubulin. This reaction is not reversible by the carboxypeptidase enzyme. Cells cultured in 3-nitrotyrosine rich medium showed evidence of altered microtubule structure and function, including altered cell morphology, epithelial barrier dysfunction, and apoptosis. Bacterial homologs of TTL are predicted to form peptide tags. Some of these are fused to a 2-oxoglutarate Fe(II)-dependent dioxygenase domain.


Pssm-ID: 397308  Cd Length: 291  Bit Score: 162.89  E-value: 8.80e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917 381 EEFFPETYRLDLkhEREAFFTLF--DETQIWICKPTASNQGKGIFLlrkqeevaalqakTRSAEDDPIHHKSpfrgpQAR 458
Cdd:pfam03133  41 GDFLPRTFILPT--DLAEFVDYFedRERNTWIVKPSASARGRGIRV-------------TNKLSQIPKWSQS-----RPL 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917 459 VVQRYIQNPLLLDGRKFDVRSYLLIACTTPYMIF-FSHGYARLTLSLYDPHSSDLSG---HLTNQFMQKKSPL---YVLL 531
Cdd:pfam03133 101 VVQKYIERPLLIDGRKFDIRLYVLVTSVNPLRVYvYREGLLRFASVKYSPSSSDLDDvemHLTNYSIQKKSSSlneDYNE 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917 532 KEDTVWSMERLNRYInttfwkaRGLPKDWVFTTLTK-RMQQIMAHCFLAAKSKLECKLGYFDLIGCDFLIDDNFKVWLLE 610
Cdd:pfam03133 181 PHGHKWSLQNFWKYL-------EEKDKDEIWLEIESiIIKTILAAEVEASRLNVQPLPNCFELYGFDFMIDENLKPWLLE 253

                         250       260
                  ....*....|....*....|....*.
gi 1622824917 611 MNSNPALHTNCEVLKEVIPGVVIETL 636
Cdd:pfam03133 254 VNSSPSLHSTTKLDARLKEQLIDDVL 279
PHA03247 PHA03247
large tegument protein UL36; Provisional
 26-256 1.83e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 55.33  E-value: 1.83e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917   26 PGRARPR-PRSSSGrgglARQRQGAETASAPHGAKPHGCHGGRSQPPTEAQVHGPGRRPFLGRVGLTACPIQVLGPRAAR 104
Cdd:PHA03247  2593 PQSARPRaPVDDRG----DPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRAR 2668

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917  105 SSHRRVKAASSLQGPRPGAPRPMAHSCTRFVHRRGPPtrtqagskrgkrPKIQRRPRARVPG-PAHERPMGSSQEE-GLP 182
Cdd:PHA03247  2669 RLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPP------------PTPEPAPHALVSAtPLPPGPAAARQASpALP 2736

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622824917  183 CQPSQPDHDTGGHGGLDLEGAGRVSTTPGPPGLLTSHPPADSDDTDATGPPAALLEGLLLGDGKPSPHSTRPGP 256
Cdd:PHA03247  2737 AAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAA 2810
ATPgrasp_YheCD pfam14398
YheC/D like ATP-grasp; A member of the ATP-grasp fold predicted to be involved in the ...
 363-615 4.87e-07

YheC/D like ATP-grasp; A member of the ATP-grasp fold predicted to be involved in the modification/biosynthesis of spore-wall and capsular proteins.


Pssm-ID: 405146 [Multi-domain]  Cd Length: 256  Bit Score: 51.80  E-value: 4.87e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917 363 DLPWTSPG---------HLRPQRVLRmeEFFPETYRLDlkhEREAFFTLFDETQIWICKPTASNQGKGIFLLRKQEEVAA 433
Cdd:pfam14398   1 GIPFFNPGffnkwevyeLLSKDPELR--PYLPETELLQ---SPEDLERMLEKYGSVYLKPVNGSLGKGILRIEKDGGGYY 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917 434 LQAKTR--------SAEDDPIHHKSPFRGPQARVVQRYIqNPLLLDGRKFDVRsyLLI--------ACTTpymiffshGY 497
Cdd:pfam14398  76 LYGRYGknsktnrfLDFSELESFLRRLLGKKRYIIQQGI-DLATIDGRPFDFR--VLVqkngkgkwVVTG--------IA 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917 498 ARLTlslyDPHS--SDLSGHLTnqfmqkksplyvllkedtvwsMERLNRYINTTFWKARGLPkdwvfttLTKRMQQImah 575
Cdd:pfam14398 145 ARIA----GPGSitTNLSGGGT---------------------AIPLEEALRRAFGEERAEK-------ILEKLEEL--- 189

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1622824917 576 CFLAAKSkLECKLGYFDLIGCDFLIDDNFKVWLLEMNSNP 615
Cdd:pfam14398 190 ALELARA-LEESFGGLGELGLDLGIDKNGRVWLLEVNSKP 228
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 686-791 3.13e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 50.75  E-value: 3.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917 686 PPPTRQAKSSGPPTPRAPDQPGTRRPVPPPLAPQRPQlPGPSPDPDSAHDGQPQAPGKEQSGTGDRHPEQEPSP---GTA 762
Cdd:PRK07764  394 PAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQ-PAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPapaPAA 472

                          90       100
                  ....*....|....*....|....*....
gi 1622824917 763 KEERKEPENARPWGGHPRPTPHAPATLPA 791
Cdd:PRK07764  473 APEPTAAPAPAPPAAPAPAAAPAAPAAPA 501
PHA03247 PHA03247
large tegument protein UL36; Provisional
 685-793 9.27e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.55  E-value: 9.27e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917  685 LPPPTRQAkssgPPTPRAPDQPGTRRPVPPPLAPQRPQLPGPSPDPDSAHDGQPQAPGkEQSGTGDRHPEQEPSPGTAKE 764
Cdd:PHA03247  2900 LPPDQPER----PPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAG-EPSGAVPQPWLGALVPGRVAV 2974

                           90       100
                   ....*....|....*....|....*....
gi 1622824917  765 ERKEPENARPWGGHPRPTPHAPATLPAFR 793
Cdd:PHA03247  2975 PRFRVPQPAPSREAPASSTPPLTGHSLSR 3003
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 688-794 2.80e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 47.76  E-value: 2.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917 688 PTRQAKSSGPPTPRAPDQPGTRRPVPPPLAPQRPQLPgPSPD-PDSAHdgQPQAPGKEQSGTGDRHP--EQEPSPGTAKE 764
Cdd:PTZ00449  573 PTLSKKPEFPKDPKHPKDPEEPKKPKRPRSAQRPTRP-KSPKlPELLD--IPKSPKRPESPKSPKRPppPQRPSSPERPE 649

                          90       100       110
                  ....*....|....*....|....*....|
gi 1622824917 765 ERKEPENARPwgghprPTPHAPATLPAFRD 794
Cdd:PTZ00449  650 GPKIIKSPKP------PKSPKPPFDPKFKE 673
PHA03378 PHA03378
EBNA-3B; Provisional
 682-788 3.35e-05

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 47.75  E-value: 3.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917 682 RRRLPP--PTRQAKSSGPPTPRAPDQPGTRRPVPPPLAPQRPQLPGPSPDPDSAHDGQPQAPGKEQSGTGD-RHPEQEPS 758
Cdd:PHA03378  693 TMQPPPraPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRaRPPAAAPG 772

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1622824917 759 PGTAKEERKEPENA--RPWGG-HPRPTPHAPAT 788
Cdd:PHA03378  773 APTPQPPPQAPPAPqqRPRGApTPQPPPQAGPT 805
PHA03247 PHA03247
large tegument protein UL36; Provisional
 681-781 3.56e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.63  E-value: 3.56e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917  681 LRRRLP---PPTRQAKSSGPPTPRAPDQPGTRRPVPPPLAPQRPQlPGPSPDPDSAHDGQPQAPGKEQSGTGDRHPEQ-- 755
Cdd:PHA03247  2862 VRRRPPsrsPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPE-RPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRpq 2940

                           90       100
                   ....*....|....*....|....*....
gi 1622824917  756 ---EPSPGTAKEERKEPENARPWGGHPRP 781
Cdd:PHA03247  2941 pplAPTTDPAGAGEPSGAVPQPWLGALVP 2969
PHA03247 PHA03247
large tegument protein UL36; Provisional
 683-791 4.67e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.24  E-value: 4.67e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917  683 RRLPPPTRQAKSSGPPTPRAPDQPGTRRPVPPPLAP----QRPQLPGPSPD--PDSAHDGQPQAPGKEQSGTGDRHPEQE 756
Cdd:PHA03247  2659 GRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSltslADPPPPPPTPEpaPHALVSATPLPPGPAAARQASPALPAA 2738

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1622824917  757 PSPGTAKEerkepENARPWGGHPRPTPHAPATLPA 791
Cdd:PHA03247  2739 PAPPAVPA-----GPATPGGPARPARPPTTAGPPA 2768
PHA03247 PHA03247
large tegument protein UL36; Provisional
 680-791 1.28e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 1.28e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917  680 SLRRRLPPPTRQAKSSGPPTPRAP--DQPGTRRPVPPPLAPQRPQLPGPSPDPDSAHDGQPQAPGKEQSgtgdRHPEQEP 757
Cdd:PHA03247  2581 AVTSRARRPDAPPQSARPRAPVDDrgDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPP----ERPRDDP 2656

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1622824917  758 SPGTAKEERKEPENARPWGGHPRPT-PHAPATLPA 791
Cdd:PHA03247  2657 APGRVSRPRRARRLGRAAQASSPPQrPRRRAARPT 2691
PHA03378 PHA03378
EBNA-3B; Provisional
 673-790 1.31e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 45.83  E-value: 1.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917 673 PRLGGSCSLRRRLPPPTRQAKSSGPPTPRAPdqpgtrrPVPPPLAPQRPQLPGPSPDPDSAHDGQPQAPgkeqSGTGDRH 752
Cdd:PHA03378  676 PSPTGANTMLPIQWAPGTMQPPPRAPTPMRP-------PAAPPGRAQRPAAATGRARPPAAAPGRARPP----AAAPGRA 744

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1622824917 753 PEQEPSPGTAKEERKEPENARPWGGHP-RPTPHAPATLP 790
Cdd:PHA03378  745 RPPAAAPGRARPPAAAPGRARPPAAAPgAPTPQPPPQAP 783
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 693-791 1.44e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 45.45  E-value: 1.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917 693 KSSGPPTPRAPDQpgTRRPVPP--PLAPQRPQLPGPSPDPDSAHDGQPQAPGKEQSGTGDRHPEQEPSPGTAKEERKEP- 769
Cdd:PTZ00449  704 KETLPETPGTPFT--TPRPLPPklPRDEEFPFEPIGDPDAEQPDDIEFFTPPEEERTFFHETPADTPLPDILAEEFKEEd 781

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1622824917 770 ---ENARPWGGHPRP------TPHAPATLPA 791
Cdd:PTZ00449  782 ihaETGEPDEAMKRPdspsehEDKPPGDHPS 812
dnaA PRK14086
chromosomal replication initiator protein DnaA;
678-791 3.23e-04

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 44.05  E-value: 3.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917 678 SCSLRRRLPPPTRQA----KSSGPPTPrapdqpgtrrPVPPPLAPQRPQLPGPSPDPDSAHDGQPQAPGKEQSGTGDRHP 753
Cdd:PRK14086   71 SETLSRELGRPIRIAitvdPSAGEPAP----------PPPHARRTSEPELPRPGRRPYEGYGGPRADDRPPGLPRQDQLP 140

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1622824917 754 EQEPSpGTAKEERKEP------ENARPW----GGHPRPTPHAPATLPA 791
Cdd:PRK14086  141 TARPA-YPAYQQRPEPgawpraADDYGWqqqrLGFPPRAPYASPASYA 187
PHA03247 PHA03247
large tegument protein UL36; Provisional
 676-793 4.35e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.16  E-value: 4.35e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917  676 GGSCSLRRRLPPPTRQAKSSGPP---TPRA--------------PDQPGTRRPVPPPLAPQRPQLPGP-----SPDPDSA 733
Cdd:PHA03247  2658 PGRVSRPRRARRLGRAAQASSPPqrpRRRAarptvgsltsladpPPPPPTPEPAPHALVSATPLPPGPaaarqASPALPA 2737

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917  734 HDGQPQAPGKEQSGTGDRHPEQEPSPGTAkeERKEPENARPWGGHPRPTPHAPATLPAFR 793
Cdd:PHA03247  2738 APAPPAVPAGPATPGGPARPARPPTTAGP--PAPAPPAAPAAGPPRRLTRPAVASLSESR 2795
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 668-787 4.85e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.82  E-value: 4.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917 668 EADVWPRLGGSCSLRRRLPPPTRQAKSSGPPTPRAPDQPGTRRPVPPPlapqrpqlPGPSPDPDSAHDGQPQAPGKEQSG 747
Cdd:PRK07764  663 SDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPP--------AGQADDPAAQPPQAAQGASAPSPA 734

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1622824917 748 TGD---RHPEQEPSPGTAKEERKE-----PENARPWGGHPRPTPHAPA 787
Cdd:PRK07764  735 ADDpvpLPPEPDDPPDPAGAPAQPppppaPAPAAAPAAAPPPSPPSEE 782
PHA03269 PHA03269
envelope glycoprotein C; Provisional
 698-793 5.49e-04

envelope glycoprotein C; Provisional


Pssm-ID: 165527 [Multi-domain]  Cd Length: 566  Bit Score: 43.56  E-value: 5.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917 698 PTPRAPDQPGTRRPVPPPLAPQRP-QLPGPSPDPDSAHDGQPQaPGKEQSGTGDRHPEQEPSPGTAKEERKEPENARPWG 776
Cdd:PHA03269   27 PIPELHTSAATQKPDPAPAPHQAAsRAPDPAVAPTSAASRKPD-LAQAPTPAASEKFDPAPAPHQAASRAPDPAVAPQLA 105

                          90
                  ....*....|....*..
gi 1622824917 777 GHPRPTPHAPATLPAFR 793
Cdd:PHA03269  106 AAPKPDAAEAFTSAAQA 122
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 687-794 6.04e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 43.16  E-value: 6.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917 687 PPTRQAKSSGPPTPRAPDQPGTRRP---VPPPLAPQRPQLPGPSPDPDSAHDGQPQAPGKEQSGTGDRHPEQEPSPGTAK 763
Cdd:PRK14951  383 RPEAAAPAAAPVAQAAAAPAPAAAPaaaASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVALAPAPPAQAAPETVAI 462

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1622824917 764 EERKEPENARPWGGHPRPTPHAPATLPAFRD 794
Cdd:PRK14951  463 PVRVAPEPAVASAAPAPAAAPAAARLTPTEE 493
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 692-791 7.81e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.05  E-value: 7.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917 692 AKSSGPPTPRAPDQPGtrrpvpPPLAPQRPQLPGPSPDPDSAHDGQPQAPGKEQSGTGdrHPEQEPSPGTAKEERKEPEN 771
Cdd:PRK07764  592 PGAAGGEGPPAPASSG------PPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAP--APGVAAPEHHPKHVAVPDAS 663

                          90       100
                  ....*....|....*....|
gi 1622824917 772 ARPWGGHPRPTPHAPATLPA 791
Cdd:PRK07764  664 DGGDGWPAKAGGAAPAAPPP 683
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 686-791 1.05e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.67  E-value: 1.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917 686 PPPTRQAKSSGPPTPRAPDQPGTRRPVPPPLAPQRPqlPGPSPDPDSahdGQPQAPGKEQSGTGDRHPEQEPSPGTAKEE 765
Cdd:PRK07764  406 PAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAP--PSPAGNAPA---GGAPSPPPAAAPSAQPAPAPAAAPEPTAAP 480

                          90       100
                  ....*....|....*....|....*.
gi 1622824917 766 RKEPENARPWGGHPRPTPHAPATLPA 791
Cdd:PRK07764  481 APAPPAAPAPAAAPAAPAAPAAPAGA 506
PHA03247 PHA03247
large tegument protein UL36; Provisional
 685-791 1.15e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 1.15e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917  685 LPPPTRQAKSSgPPTPRAPDQPG------------------TRRPVPPPLAPQRP---QLPGPSPDPDSAHDGQPQAPGK 743
Cdd:PHA03247  2828 LPPPTSAQPTA-PPPPPGPPPPSlplggsvapggdvrrrppSRSPAAKPAAPARPpvrRLARPAVSRSTESFALPPDQPE 2906

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1622824917  744 EQsgtgdRHPEQEPSPGTAKEERKEPENARPWGGHPRP-TPHAPATLPA 791
Cdd:PHA03247  2907 RP-----PQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPqPPLAPTTDPA 2950
PHA03247 PHA03247
large tegument protein UL36; Provisional
 697-794 1.54e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 1.54e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917  697 PPTPRAPDQPGTRRPVPPPLAPQRPqlPGPSPDPDSAHDGQPQAPGKEQSGTGDRHPEQEPSPGTAKEERKEPENARPWG 776
Cdd:PHA03247  2553 PPLPPAAPPAAPDRSVPPPRPAPRP--SEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPS 2630

                           90       100
                   ....*....|....*....|..
gi 1622824917  777 GHPRPT----PHAPATLPAFRD 794
Cdd:PHA03247  2631 PSPAANepdpHPPPTVPPPERP 2652
PHA03247 PHA03247
large tegument protein UL36; Provisional
 29-235 1.57e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 1.57e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917   29 ARPRPRSSSGRGGLARQRQGAETASAPHGAKPHGCHGG--RSQPPTEAQVHGPGRRPFLGRVGLTACPIQVLGPRAARSS 106
Cdd:PHA03247  2741 PPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGppRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPP 2820

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917  107 HRRVKA-----ASSLQGPRPGAPRPMAHSCTRF--------VHRRGPPTRTQAGSKRGKRPKIQRRPRARVPGPAHERPM 173
Cdd:PHA03247  2821 AASPAGplpppTSAQPTAPPPPPGPPPPSLPLGgsvapggdVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFAL 2900

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622824917  174 GSSQeeglPCQPSQPDHDTGGHGGLDLEGAGRVSTTPGPPGLLTSHPPADSDDTDATGPPAA 235
Cdd:PHA03247  2901 PPDQ----PERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGA 2958
PRK14954 PRK14954
DNA polymerase III subunits gamma and tau; Provisional
 629-763 1.62e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184918 [Multi-domain]  Cd Length: 620  Bit Score: 41.85  E-value: 1.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917 629 PGVVIETLDLALETfQKSLRGQKMLPL---LSQRRFVLLHNGEADVWPRLGGSCSLRRRLPPPTRQAKSSGPPtPRAPDQ 705
Cdd:PRK14954  336 PAAVMQMTDFLMKT-QGELKFQFEYQFrfeLALLRLIELVRNDGGVAPSPAGSPDVKKKAPEPDLPQPDRHPG-PAKPEA 413

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622824917 706 PGtRRPVPpplapqrpqlpGPSPDPDSAHDGQPQAPgkeQSGTGDRHPEQEPSPGTAK 763
Cdd:PRK14954  414 PG-ARPAE-----------LPSPASAPTPEQQPPVA---RSAPLPPSPQASAPRNVAS 456
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 686-778 2.11e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 41.62  E-value: 2.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917 686 PPPTRQAKSSGPPTPRAP---DQPGTRRPVPPPLAPQRPQLPGPSPDPDSAHDGQpQAPGKEQSGTGDRHPEQEPSPGTA 762
Cdd:PRK14951  406 APAAAASAPAAPPAAAPPapvAAPAAAAPAAAPAAAPAAVALAPAPPAQAAPETV-AIPVRVAPEPAVASAAPAPAAAPA 484

                          90
                  ....*....|....*.
gi 1622824917 763 KEERKEPENARPWGGH 778
Cdd:PRK14951  485 AARLTPTEEGDVWHAT 500
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 687-786 2.36e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 41.68  E-value: 2.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917 687 PPTRQAKSSGPPTPRAPDQPGTR--RPVPPPLAPQRPQLPGPSPDPDSAHDGQPQAPGKEQSGTGDRHPEQEPSPGTAKE 764
Cdd:pfam03154 171 PPVLQAQSGAASPPSPPPPGTTQaaTAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPLQ 250

                          90       100
                  ....*....|....*....|....
gi 1622824917 765 ERKE--PENARPWGGHPRPTPHAP 786
Cdd:pfam03154 251 PMTQppPPSQVSPQPLPQPSLHGQ 274
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 28-235 2.47e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.51  E-value: 2.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917  28 RARPRPRSSSGRGGLARQRQGAETASAPHGAKPHGCHGGRSQPPTEAQVHGPGRRPFLGRVGLTACPIQVLGPRAARSSH 107
Cdd:PRK07764  585 EAVVGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASD 664

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917 108 RRVKAASSLQGPRPGAPRPMAHSCTRFVHRRGPPTRTQAGSKRGKRPKIQRRPRARVPGPAHERPMGSSQEEGLPCQPSQ 187
Cdd:PRK07764  665 GGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPE 744

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1622824917 188 PDHDTGGHGGLDLEGAGRVSTTPGPPGllTSHPPADSDDTDATGPPAA 235
Cdd:PRK07764  745 PDDPPDPAGAPAQPPPPPAPAPAAAPA--AAPPPSPPSEEEEMAEDDA 790
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 686-794 2.94e-03

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 40.52  E-value: 2.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917 686 PPPTRQAKSSGPPTPRAPDQPGTRRPV--PPPLAPQRPQLPGPSPDPDSAHDGQPQAPGKEQSGTGDRHPEQEPSPGTAK 763
Cdd:NF040712  226 APATDSDPAEAGTPDDLASARRRRAGVeqPEDEPVGPGAAPAAEPDEATRDAGEPPAPGAAETPEAAEPPAPAPAAPAAP 305

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1622824917 764 EERKEPENARPwGGHPRPTPHAP---ATLPAFRD 794
Cdd:NF040712  306 AAPEAEEPARP-EPPPAPKPKRRrrrASVPSWDD 338
PHA03264 PHA03264
envelope glycoprotein D; Provisional
 665-787 3.32e-03

envelope glycoprotein D; Provisional


Pssm-ID: 223029 [Multi-domain]  Cd Length: 416  Bit Score: 40.76  E-value: 3.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917 665 HNGEADVWPRLGGscslrRRLPPPTRQAKSSGPPTprAPDQpGTRRPVPPPLAPQRPQlPGPSPDPDSAHDGQPQAPGKE 744
Cdd:PHA03264  239 HKAIVDYWFMRHG-----GVVPPYFEESKGYEPPP--APSG-GSPAPPGDDRPEAKPE-PGPVEDGAPGRETGGEGEGPE 309

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1622824917 745 QSGTgDRHPEQEPSPGTAkeeRKEPENARPWG-------GHPRPTPHAPA 787
Cdd:PHA03264  310 PAGR-DGAAGGEPKPGPP---RPAPDADRPEGwpsleaiTFPPPTPATPA 355
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 676-791 3.44e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.12  E-value: 3.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917 676 GGSCSLRRRLPPPTRQAKSSGPPTPRAPDQPGTRR-PVPPPLAPQRPQLPGPSPDPDSAHDGQPQA--PGKEQSGTGDRH 752
Cdd:PRK07764  638 EASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKaGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPapAATPPAGQADDP 717

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1622824917 753 PEQEPSPGTAKEERK-----------EPENARPWGGHPRPTPHAPATLPA 791
Cdd:PRK07764  718 AAQPPQAAQGASAPSpaaddpvplppEPDDPPDPAGAPAQPPPPPAPAPA 767
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 689-790 3.72e-03

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 40.52  E-value: 3.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917 689 TRQAKSSGPPTPRAPDQPGTRRPVP-------PPLAPQRPQLPGPSPDPDSahdgQPQAPGKEQSGTGDR-HPEQEPSPG 760
Cdd:NF033839  273 TKFKKGLTQDTPKEPGNKKPSAPKPgmqpspqPEKKEVKPEPETPKPEVKP----QLEKPKPEVKPQPEKpKPEVKPQLE 348

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1622824917 761 TAKEE-RKEPENARPwGGHPRPTPHAPATLP 790
Cdd:NF033839  349 TPKPEvKPQPEKPKP-EVKPQPEKPKPEVKP 378
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
687-791 4.26e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 40.63  E-value: 4.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917 687 PPTRQAKSSGPPTPRAPdqpgTRRPVPPPLAPQRPQLPGPSPDPDSAHDGQP-QAPGKEQSGTGDRHPEQEPSPGTAKEE 765
Cdd:PRK12323  434 AAARQASARGPGGAPAP----APAPAAAPAAAARPAAAGPRPVAAAAAAAPArAAPAAAPAPADDDPPPWEELPPEFASP 509

                          90       100
                  ....*....|....*....|....*.
gi 1622824917 766 RKEPENARPWGGHPRPTPHaPATLPA 791
Cdd:PRK12323  510 APAQPDAAPAGWVAESIPD-PATADP 534
PHA03247 PHA03247
large tegument protein UL36; Provisional
 684-791 4.89e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 4.89e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917  684 RLPPPTRQAKSSGPPTPRAPDQPGTRRPvPPPLAPQRPQLP-GPSPDPDSAHDGQPQAPGKEQSGTGDRHPEQEPSPGTA 762
Cdd:PHA03247  2706 PTPEPAPHALVSATPLPPGPAAARQASP-ALPAAPAPPAVPaGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLT 2784

                           90       100
                   ....*....|....*....|....*....
gi 1622824917  763 KEERKEPENARPWGGHPRPTPHAPATLPA 791
Cdd:PHA03247  2785 RPAVASLSESRESLPSPWDPADPPAAVLA 2813
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 695-787 5.02e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 40.45  E-value: 5.02e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917  695 SGPPTPRAPDQPGTRR--PVPPPLAPQRPQLPGPsPDPDSAHDGQPQAPGKEQsgtgdRHPEQEPSPGTAKEERKEPENA 772
Cdd:PRK10263   753 QQPQQPVAPQQQYQQPqqPVAPQPQYQQPQQPVA-PQPQYQQPQQPVAPQPQY-----QQPQQPVAPQPQYQQPQQPVAP 826

                           90
                   ....*....|....*
gi 1622824917  773 RPWGGHPRPtPHAPA 787
Cdd:PRK10263   827 QPQYQQPQQ-PVAPQ 840
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 687-774 5.15e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 40.45  E-value: 5.15e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917  687 PPTRQAKSSGPPTPRAPDQP--GTRRPVPPPLAPQRPQLPgPSPDPDSAHDGQPQAPGKEQsgtgdRHPEQEPSPGTAKE 764
Cdd:PRK10263   758 PVAPQQQYQQPQQPVAPQPQyqQPQQPVAPQPQYQQPQQP-VAPQPQYQQPQQPVAPQPQY-----QQPQQPVAPQPQYQ 831

                           90
                   ....*....|
gi 1622824917  765 ERKEPENARP 774
Cdd:PRK10263   832 QPQQPVAPQP 841
PHA03247 PHA03247
large tegument protein UL36; Provisional
 673-792 5.23e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 5.23e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917  673 PRLGGSCSLRRRLPP----PTRQAKSSGPPTPRAPDQPGTRRPVPPPLAPQRPQLPGPSPDPDSAHDGQPQAPGKEQSGT 748
Cdd:PHA03247  2720 PLPPGPAAARQASPAlpaaPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLP 2799

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1622824917  749 GDRHPEQEPSPGTAKEErKEPENARPWGGHPRPT---PHAPATLPAF 792
Cdd:PHA03247  2800 SPWDPADPPAAVLAPAA-ALPPAASPAGPLPPPTsaqPTAPPPPPGP 2845
dnaA PRK14086
chromosomal replication initiator protein DnaA;
684-781 5.44e-03

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 40.19  E-value: 5.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917 684 RLPPPTRQAKS-SGPPTPRAPDQP----GTRRPVP-PPLAPQRPQLPGPSPD-PDsahDGQPQAPGKEQSGTGDRHPEQE 756
Cdd:PRK14086   94 EPAPPPPHARRtSEPELPRPGRRPyegyGGPRADDrPPGLPRQDQLPTARPAyPA---YQQRPEPGAWPRAADDYGWQQQ 170

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1622824917 757 PS-------PGTAKEERKEPENARPWGGHPRP 781
Cdd:PRK14086  171 RLgfpprapYASPASYAPEQERDREPYDAGRP 202
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 686-795 6.52e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 39.97  E-value: 6.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917 686 PPPTRQAKSSGPPTPRAPDQPGTRRPVPPPLAPQRPQLPGPSPDPDSAHDGQPQAPGKEQSGTGDRHPEQEPSPGTAKEE 765
Cdd:PRK07764  703 PAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEE 782

                          90       100       110
                  ....*....|....*....|....*....|
gi 1622824917 766 RKEPENARPwggHPRPTPHAPATLPAFRDL 795
Cdd:PRK07764  783 EEMAEDDAP---SMDDEDRRDAEEVAMELL 809
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 698-788 6.66e-03

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 39.75  E-value: 6.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917 698 PTPRAPDQPGTRRP-VPPPLAPQRPQLPGPSPDPDSAHDGQPQAPGKE---QSGTGDrhPEQEPSPGTAKEERK-EPENA 772
Cdd:NF033839  405 PKPEVKPQPEKPKPeVKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPEvkpQPETPK--PEVKPQPEKPKPEVKpQPEKP 482

                          90
                  ....*....|....*.
gi 1622824917 773 RPWGGHPRPTPHAPAT 788
Cdd:NF033839  483 KPDNSKPQADDKKPST 498
PHA03247 PHA03247
large tegument protein UL36; Provisional
 682-791 6.69e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 6.69e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917  682 RRRLPPPTRQAKSSGPPT-PRAPDQPGTRRPVPPPLAPQRPQLPGPS--PDPDSAHDGQPQAPGKEQSGTGDRHPEQEPS 758
Cdd:PHA03247  2756 RPARPPTTAGPPAPAPPAaPAAGPPRRLTRPAVASLSESRESLPSPWdpADPPAAVLAPAAALPPAASPAGPLPPPTSAQ 2835

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1622824917  759 PGTAKEERKEPENARPWGG--------HPRPTPHAPATLPA 791
Cdd:PHA03247  2836 PTAPPPPPGPPPPSLPLGGsvapggdvRRRPPSRSPAAKPA 2876
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
65-256 6.92e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 39.83  E-value: 6.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917  65 GGRSQPPTEAQVHGPGRRPFLGRVGLTACPIQVLGPRAARSShrrvkAASSLQGPRPGAPRPMAHSCTRFVHRRGPPTRT 144
Cdd:PRK07003  363 TGGGAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTG-----AAGAALAPKAAAAAAATRAEAPPAAPAPPATAD 437

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917 145 QAGSKRGKRPKIQRRPRARVPGPAHERPMGsSQEEGLPCQPSQPDHDTGGHGGLDLEGAGRVSTTPGPPGLLTSHPPADS 224
Cdd:PRK07003  438 RGDDAADGDAPVPAKANARASADSRCDERD-AQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAA 516

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1622824917 225 DDTDATGPPAAlleglllgdgkPSPHSTRPGP 256
Cdd:PRK07003  517 SREDAPAAAAP-----------PAPEARPPTP 537
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 698-790 7.38e-03

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 39.75  E-value: 7.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917 698 PTPRAPDQPGTRRPV--PPPLAPQ---RPQLPGPSPD-------PDSAHDGQPQAPgkeqsgtgdrHPEQEPSPGTAKEE 765
Cdd:NF033839  339 PKPEVKPQLETPKPEvkPQPEKPKpevKPQPEKPKPEvkpqpetPKPEVKPQPEKP----------KPEVKPQPEKPKPE 408

                          90       100
                  ....*....|....*....|....*.
gi 1622824917 766 RK-EPENARPwGGHPRPTPHAPATLP 790
Cdd:NF033839  409 VKpQPEKPKP-EVKPQPEKPKPEVKP 433
dnaA PRK14086
chromosomal replication initiator protein DnaA;
667-791 8.49e-03

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 39.42  E-value: 8.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917 667 GEADVWPRLGGSCSLRR-RLPPPTRQakssgPPTPRAPDQPGTRRPVPPPlAPQRPQLPGPSPDPDSahdgqpQAPGKEQ 745
Cdd:PRK14086  153 PEPGAWPRAADDYGWQQqRLGFPPRA-----PYASPASYAPEQERDREPY-DAGRPEYDQRRRDYDH------PRPDWDR 220

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1622824917 746 SGtGDRHPEQEPSPGTAKEERKEP-ENARPWGGHPRPTPHAPATLPA 791
Cdd:PRK14086  221 PR-RDRTDRPEPPPGAGHVHRGGPgPPERDDAPVVPIRPSAPGPLAA 266
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 682-792 8.67e-03

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 39.37  E-value: 8.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917 682 RRRLPPPTRQAkssgpPTPRAPDQPGTRRPVPPPLAPQRPQLPGPSPDPDSAHDGQPQAPGKEQSGTGDRHPEQEPSPGT 761
Cdd:NF040712  196 LRPLATVPRLA-----REPADARPEEVEPAPAAEGAPATDSDPAEAGTPDDLASARRRRAGVEQPEDEPVGPGAAPAAEP 270

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1622824917 762 AKEERKEPENARPWGGHPRPTPHAPATLPAF 792
Cdd:NF040712  271 DEATRDAGEPPAPGAAETPEAAEPPAPAPAA 301
PRK11901 PRK11901
hypothetical protein; Reviewed
 695-791 8.97e-03

hypothetical protein; Reviewed


Pssm-ID: 237015 [Multi-domain]  Cd Length: 327  Bit Score: 38.90  E-value: 8.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824917 695 SGPPTPRAPDQPgtrRPVPPPLAPQRPQLPGPSPDPDSAHDGQ---------------PQAPGKEQSGTGDRHPEQEPSP 759
Cdd:PRK11901  120 SAPPISPTPTQA---APPQTPNGQQRIELPGNISDALSQQQGQvnaasqnaqgntstlPTAPATVAPSKGAKVPATAETH 196

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1622824917 760 GTAKEerkEPENARPWGGHPR--PTPHAPATLPA 791
Cdd:PRK11901  197 PTPPQ---KPATKKPAVNHHKtaTVAVPPATSGK 227
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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