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Conserved domains on  [gi|1622900023|ref|XP_014985714|]
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protein SEC13 homolog isoform X1 [Macaca mulatta]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
71-335 1.10e-36

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 136.96  E-value: 1.10e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900023  71 GTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWAHPmyGNILASCSYDRKVIIWREENGtwEKSHEHAGHDS 150
Cdd:COG2319   132 GKTLASGSADGTVRLWDLATGK--LLRTLTGHSGAVTSVAFSPD--GKLLASGSDDGTVRLWDLATG--KLLRTLTGHTG 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900023 151 SVNSVCWAPHdyGLILACGSSDGAISLlmYTGEGQWEVKKInNAHTIGCNAVSWApavvpgslidqPSGQkpnyikRFAS 230
Cdd:COG2319   206 AVRSVAFSPD--GKLLASGSADGTVRL--WDLATGKLLRTL-TGHSGSVRSVAFS-----------PDGR------LLAS 263

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900023 231 GGCDNLIKLWkeeeDGQWKEE-QKLEAHSDWVRDVAWAPSiGlptSTIASCSQDGRVFIWtcddasgNTWSPKLLHKFN- 308
Cdd:COG2319   264 GSADGTVRLW----DLATGELlRTLTGHSGGVNSVAFSPD-G---KLLASGSDDGTVRLW-------DLATGKLLRTLTg 328

                         250       260
                  ....*....|....*....|....*....
gi 1622900023 309 --DVVWHVSWSITANILAVSGGDNKVTLW 335
Cdd:COG2319   329 htGAVRSVAFSPDGKTLASGSDDGTVRLW 357
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
71-335 1.10e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 136.96  E-value: 1.10e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900023  71 GTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWAHPmyGNILASCSYDRKVIIWREENGtwEKSHEHAGHDS 150
Cdd:COG2319   132 GKTLASGSADGTVRLWDLATGK--LLRTLTGHSGAVTSVAFSPD--GKLLASGSDDGTVRLWDLATG--KLLRTLTGHTG 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900023 151 SVNSVCWAPHdyGLILACGSSDGAISLlmYTGEGQWEVKKInNAHTIGCNAVSWApavvpgslidqPSGQkpnyikRFAS 230
Cdd:COG2319   206 AVRSVAFSPD--GKLLASGSADGTVRL--WDLATGKLLRTL-TGHSGSVRSVAFS-----------PDGR------LLAS 263

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900023 231 GGCDNLIKLWkeeeDGQWKEE-QKLEAHSDWVRDVAWAPSiGlptSTIASCSQDGRVFIWtcddasgNTWSPKLLHKFN- 308
Cdd:COG2319   264 GSADGTVRLW----DLATGELlRTLTGHSGGVNSVAFSPD-G---KLLASGSDDGTVRLW-------DLATGKLLRTLTg 328

                         250       260
                  ....*....|....*....|....*....
gi 1622900023 309 --DVVWHVSWSITANILAVSGGDNKVTLW 335
Cdd:COG2319   329 htGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 56-335 1.75e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 120.52  E-value: 1.75e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900023  56 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGgqILIADLRGHEGPVWQVAWAHpmYGNILASCSYDRKVIIWREE 135
Cdd:cd00200     6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG--ELLRTLKGHTGPVRDVAASA--DGTYLASGSSDKTIRLWDLE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900023 136 NGtwEKSHEHAGHDSSVNSVCWAPHDYglILACGSSDGAISLlmytgegqWEVKKIN-----NAHTIGCNAVSWAPAvvp 210
Cdd:cd00200    82 TG--ECVRTLTGHTSYVSSVAFSPDGR--ILSSSSRDKTIKV--------WDVETGKclttlRGHTDWVNSVAFSPD--- 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900023 211 gslidqpsgqkpnyiKRFASGGC-DNLIKLWkeeEDGQWKEEQKLEAHSDWVRDVAWAPSiglpTSTIASCSQDGRVFIW 289
Cdd:cd00200   147 ---------------GTFVASSSqDGTIKLW---DLRTGKCVATLTGHTGEVNSVAFSPD----GEKLLSSSSDGTIKLW 204

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1622900023 290 tcdDASGNTWSpKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLW 335
Cdd:cd00200   205 ---DLSTGKCL-GTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVW 246
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 95-132 1.79e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 1.79e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1622900023   95 LIADLRGHEGPVWQVAWAHpmYGNILASCSYDRKVIIW 132
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSP--DGKYLASGSDDGTIKLW 39
PTZ00420 PTZ00420
coronin; Provisional
 57-136 1.65e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 43.40  E-value: 1.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900023  57 SHEDMIHDAQMD-YYGTRLATCSSDRSVKIFDVRNGGQIL--IAD----LRGHEGPVWQVAWaHPMYGNILASCSYDRKV 129
Cdd:PTZ00420   72 GHTSSILDLQFNpCFSEILASGSEDLTIRVWEIPHNDESVkeIKDpqciLKGHKKKISIIDW-NPMNYYIMCSSGFDSFV 150


                  ....*..
gi 1622900023 130 IIWREEN 136
Cdd:PTZ00420  151 NIWDIEN 157
WD40 pfam00400
WD domain, G-beta repeat;
248-289 3.17e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 3.17e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1622900023 248 WKEEQKLEAHSDWVRDVAWAPSiglpTSTIASCSQDGRVFIW 289
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPD----GKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
71-335 1.10e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 136.96  E-value: 1.10e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900023  71 GTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWAHPmyGNILASCSYDRKVIIWREENGtwEKSHEHAGHDS 150
Cdd:COG2319   132 GKTLASGSADGTVRLWDLATGK--LLRTLTGHSGAVTSVAFSPD--GKLLASGSDDGTVRLWDLATG--KLLRTLTGHTG 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900023 151 SVNSVCWAPHdyGLILACGSSDGAISLlmYTGEGQWEVKKInNAHTIGCNAVSWApavvpgslidqPSGQkpnyikRFAS 230
Cdd:COG2319   206 AVRSVAFSPD--GKLLASGSADGTVRL--WDLATGKLLRTL-TGHSGSVRSVAFS-----------PDGR------LLAS 263

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900023 231 GGCDNLIKLWkeeeDGQWKEE-QKLEAHSDWVRDVAWAPSiGlptSTIASCSQDGRVFIWtcddasgNTWSPKLLHKFN- 308
Cdd:COG2319   264 GSADGTVRLW----DLATGELlRTLTGHSGGVNSVAFSPD-G---KLLASGSDDGTVRLW-------DLATGKLLRTLTg 328

                         250       260
                  ....*....|....*....|....*....
gi 1622900023 309 --DVVWHVSWSITANILAVSGGDNKVTLW 335
Cdd:COG2319   329 htGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
71-335 2.81e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 133.11  E-value: 2.81e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900023  71 GTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWAHPmyGNILASCSYDRKVIIWREENGTWEKSHEhaGHDS 150
Cdd:COG2319   174 GKLLASGSDDGTVRLWDLATGK--LLRTLTGHTGAVRSVAFSPD--GKLLASGSADGTVRLWDLATGKLLRTLT--GHSG 247

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900023 151 SVNSVCWAPhDyGLILACGSSDGAISLlmytgegqWEVK-----KINNAHTIGCNAVSWApavvpgslidqPSGqkpnyi 225
Cdd:COG2319   248 SVRSVAFSP-D-GRLLASGSADGTVRL--------WDLAtgellRTLTGHSGGVNSVAFS-----------PDG------ 300

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900023 226 KRFASGGCDNLIKLWkeeEDGQWKEEQKLEAHSDWVRDVAWAPSiglpTSTIASCSQDGRVFIWtcddasgNTWSPKLLH 305
Cdd:COG2319   301 KLLASGSDDGTVRLW---DLATGKLLRTLTGHTGAVRSVAFSPD----GKTLASGSDDGTVRLW-------DLATGELLR 366

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1622900023 306 KFN---DVVWHVSWSITANILAVSGGDNKVTLW 335
Cdd:COG2319   367 TLTghtGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
56-335 2.27e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 130.80  E-value: 2.27e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900023  56 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWAHPmyGNILASCSYDRKVIIWREE 135
Cdd:COG2319    75 LGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGL--LLRTLTGHTGAVRSVAFSPD--GKTLASGSADGTVRLWDLA 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900023 136 NGtwEKSHEHAGHDSSVNSVCWAPhDyGLILACGSSDGAISLL-MYTGEGQWEVKkinnAHTIGCNAVSWApavvpgsli 214
Cdd:COG2319   151 TG--KLLRTLTGHSGAVTSVAFSP-D-GKLLASGSDDGTVRLWdLATGKLLRTLT----GHTGAVRSVAFS--------- 213

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900023 215 dqPSGQkpnyikRFASGGCDNLIKLWkEEEDGqwKEEQKLEAHSDWVRDVAWAPSiGlptSTIASCSQDGRVFIWtcdDA 294
Cdd:COG2319   214 --PDGK------LLASGSADGTVRLW-DLATG--KLLRTLTGHSGSVRSVAFSPD-G---RLLASGSADGTVRLW---DL 275

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1622900023 295 SGNTWsPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLW 335
Cdd:COG2319   276 ATGEL-LRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 56-335 1.75e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 120.52  E-value: 1.75e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900023  56 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGgqILIADLRGHEGPVWQVAWAHpmYGNILASCSYDRKVIIWREE 135
Cdd:cd00200     6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG--ELLRTLKGHTGPVRDVAASA--DGTYLASGSSDKTIRLWDLE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900023 136 NGtwEKSHEHAGHDSSVNSVCWAPHDYglILACGSSDGAISLlmytgegqWEVKKIN-----NAHTIGCNAVSWAPAvvp 210
Cdd:cd00200    82 TG--ECVRTLTGHTSYVSSVAFSPDGR--ILSSSSRDKTIKV--------WDVETGKclttlRGHTDWVNSVAFSPD--- 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900023 211 gslidqpsgqkpnyiKRFASGGC-DNLIKLWkeeEDGQWKEEQKLEAHSDWVRDVAWAPSiglpTSTIASCSQDGRVFIW 289
Cdd:cd00200   147 ---------------GTFVASSSqDGTIKLW---DLRTGKCVATLTGHTGEVNSVAFSPD----GEKLLSSSSDGTIKLW 204

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1622900023 290 tcdDASGNTWSpKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLW 335
Cdd:cd00200   205 ---DLSTGKCL-GTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVW 246
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 53-336 4.58e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 113.97  E-value: 4.58e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900023  53 TVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWaHPMyGNILASCSYDRKVIIW 132
Cdd:cd00200    45 RTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE--CVRTLTGHTSYVSSVAF-SPD-GRILSSSSRDKTIKVW 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900023 133 REENGtwEKSHEHAGHDSSVNSVCWAPHdyGLILACGSSDGAISLlmytgegqWEVKKIN-----NAHTIGCNAVSWApa 207
Cdd:cd00200   121 DVETG--KCLTTLRGHTDWVNSVAFSPD--GTFVASSSQDGTIKL--------WDLRTGKcvatlTGHTGEVNSVAFS-- 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900023 208 vvpgslidqPSGqkpnyiKRFASGGCDNLIKLWkEEEDGQWKEEqkLEAHSDWVRDVAWAPSIGLptstIASCSQDGRVF 287
Cdd:cd00200   187 ---------PDG------EKLLSSSSDGTIKLW-DLSTGKCLGT--LRGHENGVNSVAFSPDGYL----LASGSEDGTIR 244

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1622900023 288 IWtcddasgNTWSPKLLHKF---NDVVWHVSWSITANILAVSGGDNKVTLWK 336
Cdd:cd00200   245 VW-------DLRTGECVQTLsghTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
71-335 1.49e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 109.23  E-value: 1.49e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900023  71 GTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWAHPmyGNILASCSYDRKVIIWREENGTWEksHEHAGHDS 150
Cdd:COG2319    48 GARLAAGAGDLTLLLLDAAAGA--LLATLLGHTAAVLSVAFSPD--GRLLASASADGTVRLWDLATGLLL--RTLTGHTG 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900023 151 SVNSVCWAPhDyGLILACGSSDGAISLL-MYTGEGQWEVKkinnAHTIGCNAVSWApavvpgslidqPSGqkpnyiKRFA 229
Cdd:COG2319   122 AVRSVAFSP-D-GKTLASGSADGTVRLWdLATGKLLRTLT----GHSGAVTSVAFS-----------PDG------KLLA 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900023 230 SGGCDNLIKLWkeeEDGQWKEEQKLEAHSDWVRDVAWAPSiGlptSTIASCSQDGRVFIWtcdDASGNTWsPKLLHKFND 309
Cdd:COG2319   179 SGSDDGTVRLW---DLATGKLLRTLTGHTGAVRSVAFSPD-G---KLLASGSADGTVRLW---DLATGKL-LRTLTGHSG 247

                         250       260
                  ....*....|....*....|....*.
gi 1622900023 310 VVWHVSWSITANILAVSGGDNKVTLW 335
Cdd:COG2319   248 SVRSVAFSPDGRLLASGSADGTVRLW 273
WD40 COG2319
WD40 repeat [General function prediction only];
56-133 5.42e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.39  E-value: 5.42e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622900023  56 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWAHPmyGNILASCSYDRKVIIWR 133
Cdd:COG2319   327 TGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGE--LLRTLTGHTGAVTSVAFSPD--GRTLASGSADGTVRLWD 400
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 95-132 1.79e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 1.79e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1622900023   95 LIADLRGHEGPVWQVAWAHpmYGNILASCSYDRKVIIW 132
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSP--DGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 247-289 7.96e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 7.96e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1622900023  247 QWKEEQKLEAHSDWVRDVAWAPSiglpTSTIASCSQDGRVFIW 289
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPD----GKYLASGSDDGTIKLW 39
PTZ00420 PTZ00420
coronin; Provisional
 57-136 1.65e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 43.40  E-value: 1.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900023  57 SHEDMIHDAQMD-YYGTRLATCSSDRSVKIFDVRNGGQIL--IAD----LRGHEGPVWQVAWaHPMYGNILASCSYDRKV 129
Cdd:PTZ00420   72 GHTSSILDLQFNpCFSEILASGSEDLTIRVWEIPHNDESVkeIKDpqciLKGHKKKISIIDW-NPMNYYIMCSSGFDSFV 150


                  ....*..
gi 1622900023 130 IIWREEN 136
Cdd:PTZ00420  151 NIWDIEN 157
WD40 pfam00400
WD domain, G-beta repeat;
248-289 3.17e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 3.17e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1622900023 248 WKEEQKLEAHSDWVRDVAWAPSiglpTSTIASCSQDGRVFIW 289
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPD----GKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
95-132 3.30e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 3.30e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1622900023  95 LIADLRGHEGPVWQVAWAHpmYGNILASCSYDRKVIIW 132
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSP--DGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 138-177 1.76e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 1.76e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1622900023  138 TWEKSHEHAGHDSSVNSVCWAPHdyGLILACGSSDGAISL 177
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPD--GKYLASGSDDGTIKL 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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