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Conserved domains on  [gi|966925063|ref|XP_014985358|]
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cilia- and flagella-associated protein 44 isoform X4 [Macaca mulatta]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 12822048)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
234-599 2.88e-24

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 107.30  E-value: 2.88e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925063  234 VNFNYSGTLLASVGSnpDYTLTIWNWKEEQPILRTKAFSQEVFKVTFNPDNEEQLTTSGSGHIKFWEMAftfTGLKLQGS 313
Cdd:COG2319    84 VAFSPDGRLLASASA--DGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA---TGKLLRTL 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925063  314 LGRFGKTTTTDIegymeLPDGKVL-SGSEWGNMLLWE---GGLIKVelCRGtskscHNGPINQIML--DEGEVITVGSDG 387
Cdd:COG2319   159 TGHSGAVTSVAF-----SPDGKLLaSGSDDGTVRLWDlatGKLLRT--LTG-----HTGAVRSVAFspDGKLLASGSADG 226

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925063  388 CVRIWDFETidtadiidetGlleiEPINELQVDKNVNL---FSmtkmsetGNNFWLA---QDANGAIWKLDlsfsniTQD 461
Cdd:COG2319   227 TVRLWDLAT----------G----KLLRTLTGHSGSVRsvaFS-------PDGRLLAsgsADGTVRLWDLA------TGE 279

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925063  462 PECLFSFHSGAVEAVAVSPLTYLMATTALDCSVRIYDFASKTLLTQMKFKQGG-TALVWVPrmvnfTGAEIIVGFEDGVV 540
Cdd:COG2319   280 LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAvRSVAFSP-----DGKTLASGSDDGTV 354

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 966925063  541 RVLELYDPKGLTIFVGrkkisdadirlkqvfkpHTARVTALAYERDGEILATGSKDQTV 599
Cdd:COG2319   355 RLWDLATGELLRTLTG-----------------HTGAVTSVAFSPDGRTLASGSADGTV 396
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 567-639 1.43e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 45.40  E-value: 1.43e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966925063  567 LKQVFKPHTARVTALAYERDGEILATGSKDQTVFFFEVERDYKPIGYINTPGPVCQLMWSPmshlESTLLIIC 639
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASA----DGTYLASG 69
PTZ00121 super family cl31754
MAEBL; Provisional
 917-1229 1.47e-03

MAEBL; Provisional


The actual alignment was detected with superfamily member PTZ00121:

Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.59  E-value: 1.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925063  917 EDPKAYSIENARRKREHDKLMKEVEEIKAQkrEQIKALRTEFCKLLEMNEELPTHMQFKRTDFDVDSKIRAEMHRRTAFK 996
Cdd:PTZ00121 1508 AKKKADEAKKAEEAKKADEAKKAEEAKKAD--EAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEE 1585

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925063  997 IQQVEKELAWEKEKHELGLKKLKNRFRDPLESDTIVVHAILSDHKISSYRLVQPSKYSKFKRTSQSERKPSKLDRFEKEG 1076
Cdd:PTZ00121 1586 AKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAE 1665

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925063 1077 TGRKDSQRDAGGSIAIQEESiiEKGKKfrpktlseimvENQIEKTRKLILKAERAQLKIQQRKKEWEELYKSkpgDDYED 1156
Cdd:PTZ00121 1666 EAKKAEEDKKKAEEAKKAEE--DEKKA-----------AEALKKEAEEAKKAEELKKKEAEEKKKAEELKKA---EEENK 1729

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966925063 1157 PKDLQAIKEAQvymgdfnlktaPDYKIPEHMRINAAKKEEelghldslVHGNKRYMNKCILSLRDLKVAVVEE 1229
Cdd:PTZ00121 1730 IKAEEAKKEAE-----------EDKKKAEEAKKDEEEKKK--------IAHLKKEEEKKAEEIRKEKEAVIEE 1783
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
234-599 2.88e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 107.30  E-value: 2.88e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925063  234 VNFNYSGTLLASVGSnpDYTLTIWNWKEEQPILRTKAFSQEVFKVTFNPDNEEQLTTSGSGHIKFWEMAftfTGLKLQGS 313
Cdd:COG2319    84 VAFSPDGRLLASASA--DGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA---TGKLLRTL 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925063  314 LGRFGKTTTTDIegymeLPDGKVL-SGSEWGNMLLWE---GGLIKVelCRGtskscHNGPINQIML--DEGEVITVGSDG 387
Cdd:COG2319   159 TGHSGAVTSVAF-----SPDGKLLaSGSDDGTVRLWDlatGKLLRT--LTG-----HTGAVRSVAFspDGKLLASGSADG 226

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925063  388 CVRIWDFETidtadiidetGlleiEPINELQVDKNVNL---FSmtkmsetGNNFWLA---QDANGAIWKLDlsfsniTQD 461
Cdd:COG2319   227 TVRLWDLAT----------G----KLLRTLTGHSGSVRsvaFS-------PDGRLLAsgsADGTVRLWDLA------TGE 279

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925063  462 PECLFSFHSGAVEAVAVSPLTYLMATTALDCSVRIYDFASKTLLTQMKFKQGG-TALVWVPrmvnfTGAEIIVGFEDGVV 540
Cdd:COG2319   280 LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAvRSVAFSP-----DGKTLASGSDDGTV 354

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 966925063  541 RVLELYDPKGLTIFVGrkkisdadirlkqvfkpHTARVTALAYERDGEILATGSKDQTV 599
Cdd:COG2319   355 RLWDLATGELLRTLTG-----------------HTGAVTSVAFSPDGRTLASGSADGTV 396
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 234-599 1.19e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 97.02  E-value: 1.19e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925063  234 VNFNYSGTLLASVGSnpDYTLTIWNWKEEQPILRTKAFSQEVFKVTFNPDNEEQLTTSGSGHIKFW-----EMAFTFTGL 308
Cdd:cd00200    15 VAFSPDGKLLATGSG--DGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWdletgECVRTLTGH 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925063  309 KLQGSLGRFgkttttdiegymeLPDGKVLSGSEW-GNMLLWEggLIKVELCrgTSKSCHNGPINQI-MLDEGEVITVGS- 385
Cdd:cd00200    93 TSYVSSVAF-------------SPDGRILSSSSRdKTIKVWD--VETGKCL--TTLRGHTDWVNSVaFSPDGTFVASSSq 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925063  386 DGCVRIWDFETIdtadiidetglleiepinelqvdknvnlfsmtkmsetgnnfwlaqdangaiwkldlsfsnitqdpECL 465
Cdd:cd00200   156 DGTIKLWDLRTG-----------------------------------------------------------------KCV 170

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925063  466 --FSFHSGAVEAVAVSPLTYLMATTALDCSVRIYDFASKTLLTQMKFKQGG-TALVWvprmvNFTGAEIIVGFEDGVVRV 542
Cdd:cd00200   171 atLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGvNSVAF-----SPDGYLLASGSEDGTIRV 245

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 966925063  543 lelYDpkgltifvGRKKisdadiRLKQVFKPHTARVTALAYERDGEILATGSKDQTV 599
Cdd:cd00200   246 ---WD--------LRTG------ECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTI 285
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 566-603 4.19e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 4.19e-05
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 966925063    566 RLKQVFKPHTARVTALAYERDGEILATGSKDQTVFFFE 603
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
566-603 1.15e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 1.15e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 966925063   566 RLKQVFKPHTARVTALAYERDGEILATGSKDQTVFFFE 603
Cdd:pfam00400    2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 567-639 1.43e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.40  E-value: 1.43e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966925063  567 LKQVFKPHTARVTALAYERDGEILATGSKDQTVFFFEVERDYKPIGYINTPGPVCQLMWSPmshlESTLLIIC 639
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASA----DGTYLASG 69
PTZ00121 PTZ00121
MAEBL; Provisional
 917-1229 1.47e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.59  E-value: 1.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925063  917 EDPKAYSIENARRKREHDKLMKEVEEIKAQkrEQIKALRTEFCKLLEMNEELPTHMQFKRTDFDVDSKIRAEMHRRTAFK 996
Cdd:PTZ00121 1508 AKKKADEAKKAEEAKKADEAKKAEEAKKAD--EAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEE 1585

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925063  997 IQQVEKELAWEKEKHELGLKKLKNRFRDPLESDTIVVHAILSDHKISSYRLVQPSKYSKFKRTSQSERKPSKLDRFEKEG 1076
Cdd:PTZ00121 1586 AKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAE 1665

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925063 1077 TGRKDSQRDAGGSIAIQEESiiEKGKKfrpktlseimvENQIEKTRKLILKAERAQLKIQQRKKEWEELYKSkpgDDYED 1156
Cdd:PTZ00121 1666 EAKKAEEDKKKAEEAKKAEE--DEKKA-----------AEALKKEAEEAKKAEELKKKEAEEKKKAEELKKA---EEENK 1729

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966925063 1157 PKDLQAIKEAQvymgdfnlktaPDYKIPEHMRINAAKKEEelghldslVHGNKRYMNKCILSLRDLKVAVVEE 1229
Cdd:PTZ00121 1730 IKAEEAKKEAE-----------EDKKKAEEAKKDEEEKKK--------IAHLKKEEEKKAEEIRKEKEAVIEE 1783
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
234-599 2.88e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 107.30  E-value: 2.88e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925063  234 VNFNYSGTLLASVGSnpDYTLTIWNWKEEQPILRTKAFSQEVFKVTFNPDNEEQLTTSGSGHIKFWEMAftfTGLKLQGS 313
Cdd:COG2319    84 VAFSPDGRLLASASA--DGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA---TGKLLRTL 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925063  314 LGRFGKTTTTDIegymeLPDGKVL-SGSEWGNMLLWE---GGLIKVelCRGtskscHNGPINQIML--DEGEVITVGSDG 387
Cdd:COG2319   159 TGHSGAVTSVAF-----SPDGKLLaSGSDDGTVRLWDlatGKLLRT--LTG-----HTGAVRSVAFspDGKLLASGSADG 226

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925063  388 CVRIWDFETidtadiidetGlleiEPINELQVDKNVNL---FSmtkmsetGNNFWLA---QDANGAIWKLDlsfsniTQD 461
Cdd:COG2319   227 TVRLWDLAT----------G----KLLRTLTGHSGSVRsvaFS-------PDGRLLAsgsADGTVRLWDLA------TGE 279

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925063  462 PECLFSFHSGAVEAVAVSPLTYLMATTALDCSVRIYDFASKTLLTQMKFKQGG-TALVWVPrmvnfTGAEIIVGFEDGVV 540
Cdd:COG2319   280 LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAvRSVAFSP-----DGKTLASGSDDGTV 354

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 966925063  541 RVLELYDPKGLTIFVGrkkisdadirlkqvfkpHTARVTALAYERDGEILATGSKDQTV 599
Cdd:COG2319   355 RLWDLATGELLRTLTG-----------------HTGAVTSVAFSPDGRTLASGSADGTV 396
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 234-599 1.19e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 97.02  E-value: 1.19e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925063  234 VNFNYSGTLLASVGSnpDYTLTIWNWKEEQPILRTKAFSQEVFKVTFNPDNEEQLTTSGSGHIKFW-----EMAFTFTGL 308
Cdd:cd00200    15 VAFSPDGKLLATGSG--DGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWdletgECVRTLTGH 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925063  309 KLQGSLGRFgkttttdiegymeLPDGKVLSGSEW-GNMLLWEggLIKVELCrgTSKSCHNGPINQI-MLDEGEVITVGS- 385
Cdd:cd00200    93 TSYVSSVAF-------------SPDGRILSSSSRdKTIKVWD--VETGKCL--TTLRGHTDWVNSVaFSPDGTFVASSSq 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925063  386 DGCVRIWDFETIdtadiidetglleiepinelqvdknvnlfsmtkmsetgnnfwlaqdangaiwkldlsfsnitqdpECL 465
Cdd:cd00200   156 DGTIKLWDLRTG-----------------------------------------------------------------KCV 170

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925063  466 --FSFHSGAVEAVAVSPLTYLMATTALDCSVRIYDFASKTLLTQMKFKQGG-TALVWvprmvNFTGAEIIVGFEDGVVRV 542
Cdd:cd00200   171 atLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGvNSVAF-----SPDGYLLASGSEDGTIRV 245

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 966925063  543 lelYDpkgltifvGRKKisdadiRLKQVFKPHTARVTALAYERDGEILATGSKDQTV 599
Cdd:cd00200   246 ---WD--------LRTG------ECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
238-627 1.39e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.22  E-value: 1.39e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925063  238 YSGTLLASVGSNPDYTLTIWNWKEEQPILRTKAFSQEVFKVTFNPDNEEQLTTSGSGHIKFWEMAftfTGLKLQGSLGRF 317
Cdd:COG2319    44 ASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLA---TGLLLRTLTGHT 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925063  318 GKTTTTDIEgymelPDGK-VLSGSEWGNMLLWE---GGLIKVelcrgtsKSCHNGPINQIML--DEGEVITVGSDGCVRI 391
Cdd:COG2319   121 GAVRSVAFS-----PDGKtLASGSADGTVRLWDlatGKLLRT-------LTGHSGAVTSVAFspDGKLLASGSDDGTVRL 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925063  392 WDFETidtadiidetGlleiEPINELQVDKNVnLFSMTkMSETGNnfWLA---QDANGAIWKLDlsfsniTQDPECLFSF 468
Cdd:COG2319   189 WDLAT----------G----KLLRTLTGHTGA-VRSVA-FSPDGK--LLAsgsADGTVRLWDLA------TGKLLRTLTG 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925063  469 HSGAVEAVAVSPLTYLMATTALDCSVRIYDFASKTLLTQMKFKQGG-TALVWVPrmvnfTGAEIIVGFEDGVVRVLELyd 547
Cdd:COG2319   245 HSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGvNSVAFSP-----DGKLLASGSDDGTVRLWDL-- 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925063  548 pkgltifvgrkkisdADIRLKQVFKPHTARVTALAYERDGEILATGSKDQTVFFFEVERDYKPIGYINTPGPVCQLMWSP 627
Cdd:COG2319   318 ---------------ATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP 382
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 209-498 2.71e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 90.09  E-value: 2.71e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925063  209 IIIYEYPSLRPYRILRdGTEKGYAYVNFNYSGTLLASVGSnpDYTLTIWNWKEEQPILRTKAFSQEVFKVTFNPDNEEQL 288
Cdd:cd00200    33 IKVWDLETGELLRTLK-GHTGPVRDVAASADGTYLASGSS--DKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925063  289 TTSGSGHIKFWEMA-----FTFTGLKLQGSLGRFgkttttdiegymeLPDGKVLSGSEW-GNMLLWEGGLIKvelCRGTS 362
Cdd:cd00200   110 SSSRDKTIKVWDVEtgkclTTLRGHTDWVNSVAF-------------SPDGTFVASSSQdGTIKLWDLRTGK---CVATL 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925063  363 KScHNGPINQIML--DEGEVITVGSDGCVRIWDFETIDTadiideTGLLEI--EPINELQVDKNVNLFSmtkmsetgnnf 438
Cdd:cd00200   174 TG-HTGEVNSVAFspDGEKLLSSSSDGTIKLWDLSTGKC------LGTLRGheNGVNSVAFSPDGYLLA----------- 235

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966925063  439 wlAQDANGAI--WKLDlsfsnitqDPECLFSF--HSGAVEAVAVSPLTYLMATTALDCSVRIYD 498
Cdd:cd00200   236 --SGSEDGTIrvWDLR--------TGECVQTLsgHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 332-627 7.90e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 88.55  E-value: 7.90e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925063  332 PDGKVL-SGSEWGNMLLW--EGGLIKVELCrGtskscHNGPINQIML--DEGEVITVGSDGCVRIWDFETIdtadiidet 406
Cdd:cd00200    19 PDGKLLaTGSGDGTIKVWdlETGELLRTLK-G-----HTGPVRDVAAsaDGTYLASGSSDKTIRLWDLETG--------- 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925063  407 glleiEPINELQVDKNvNLFSMTKMSetgNNFWLA---QDANGAIWKLDlsfsnitqDPECLFSF--HSGAVEAVAVSPL 481
Cdd:cd00200    84 -----ECVRTLTGHTS-YVSSVAFSP---DGRILSsssRDKTIKVWDVE--------TGKCLTTLrgHTDWVNSVAFSPD 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925063  482 TYLMATTALDCSVRIYDFASKTLLTQMKFKQGG-TALVWVPrmvnfTGAEIIVGFEDGVVRVLELYDPKgltifvgrkki 560
Cdd:cd00200   147 GTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEvNSVAFSP-----DGEKLLSSSSDGTIKLWDLSTGK----------- 210

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966925063  561 sdadirLKQVFKPHTARVTALAYERDGEILATGSKDQTVFFFEVERDYKPIGYINTPGPVCQLMWSP 627
Cdd:cd00200   211 ------CLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP 271
WD40 COG2319
WD40 repeat [General function prediction only];
239-627 1.22e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 78.03  E-value: 1.22e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925063  239 SGTLLASVGSNPDYTLTIWNWKEEQPILRTKAFSQEVFKVTFNPDNEEQLTTSGSGHIKFWEMAFTFTGLKLQGSLGRfg 318
Cdd:COG2319     3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA-- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925063  319 kttttdIEGYMELPDGKVL-SGSEWGNMLLW--EGGLIKVELcrgtskSCHNGPINQIML--DEGEVITVGSDGCVRIWD 393
Cdd:COG2319    81 ------VLSVAFSPDGRLLaSASADGTVRLWdlATGLLLRTL------TGHTGAVRSVAFspDGKTLASGSADGTVRLWD 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925063  394 fetidtadiidetglleiepinelqvdknvnlfsmtkmsetgnnfwlaqdangaiwkldlsfsniTQDPECLFSF--HSG 471
Cdd:COG2319   149 -----------------------------------------------------------------LATGKLLRTLtgHSG 163

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925063  472 AVEAVAVSPLTYLMATTALDCSVRIYDFASKTLLTQMKfkqGGTALVWVprmVNFT--GAEIIVGFEDGVVRVLELYDPK 549
Cdd:COG2319   164 AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT---GHTGAVRS---VAFSpdGKLLASGSADGTVRLWDLATGK 237

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966925063  550 GLTIFVGrkkisdadirlkqvfkpHTARVTALAYERDGEILATGSKDQTVFFFEVErDYKPIGYINTP-GPVCQLMWSP 627
Cdd:COG2319   238 LLRTLTG-----------------HSGSVRSVAFSPDGRLLASGSADGTVRLWDLA-TGELLRTLTGHsGGVNSVAFSP 298
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 158-393 9.94e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 67.36  E-value: 9.94e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925063  158 IYIAG--NQLIFLNLKTKEQIylRSSSGEGIGVIGVHPHKTYFIVAekGSFPD--IIIYEYPSLRPYRILRdGTEKGYAY 233
Cdd:cd00200    66 LASGSsdKTIRLWDLETGECV--RTLTGHTSYVSSVAFSPDGRILS--SSSRDktIKVWDVETGKCLTTLR-GHTDWVNS 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925063  234 VNFNYSGTLLASVGSnpDYTLTIWNWKEEQPILRTKAFSQEVFKVTFNPDNEEQLTTSGSGHIKFWEMAFTFTGLKLQGS 313
Cdd:cd00200   141 VAFSPDGTFVASSSQ--DGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGH 218

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925063  314 LGRFgktTTTDIegymeLPDGK-VLSGSEWGNMLLWegglikvELCRGTSKSC---HNGPINQIML--DEGEVITVGSDG 387
Cdd:cd00200   219 ENGV---NSVAF-----SPDGYlLASGSEDGTIRVW-------DLRTGECVQTlsgHTNSVTSLAWspDGKRLASGSADG 283


                  ....*.
gi 966925063  388 CVRIWD 393
Cdd:cd00200   284 TIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
234-396 2.26e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 67.63  E-value: 2.26e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925063  234 VNFNYSGTLLASVGSnpDYTLTIWNWKEEQPILRTKAFSQEVFKVTFNPDNEeQL-TTSGSGHIKFWEMAftfTGLKLQG 312
Cdd:COG2319   252 VAFSPDGRLLASGSA--DGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGK-LLaSGSDDGTVRLWDLA---TGKLLRT 325

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925063  313 SLGRFGKTTTTDIegymeLPDGKVL-SGSEWGNMLLW--EGGLIKVELcRGtskscHNGPINQIML--DEGEVITVGSDG 387
Cdd:COG2319   326 LTGHTGAVRSVAF-----SPDGKTLaSGSDDGTVRLWdlATGELLRTL-TG-----HTGAVTSVAFspDGRTLASGSADG 394


                  ....*....
gi 966925063  388 CVRIWDFET 396
Cdd:COG2319   395 TVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
209-396 2.49e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 67.63  E-value: 2.49e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925063  209 IIIYEYPSLRPYRILRDGTEKGYAyVNFNYSGTLLASVGSnpDYTLTIWNWKEEQPILRTKAFSQEVFKVTFNPDNeEQL 288
Cdd:COG2319   186 VRLWDLATGKLLRTLTGHTGAVRS-VAFSPDGKLLASGSA--DGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDG-RLL 261

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925063  289 -TTSGSGHIKFWEMAftfTGLKLQGSLGRFGKTTTTDIegymeLPDGKVL-SGSEWGNMLLWEGGLIKvelCRGTSKScH 366
Cdd:COG2319   262 aSGSADGTVRLWDLA---TGELLRTLTGHSGGVNSVAF-----SPDGKLLaSGSDDGTVRLWDLATGK---LLRTLTG-H 329

                         170       180       190
                  ....*....|....*....|....*....|..
gi 966925063  367 NGPINQIML--DEGEVITVGSDGCVRIWDFET 396
Cdd:COG2319   330 TGAVRSVAFspDGKTLASGSDDGTVRLWDLAT 361
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 469-631 3.99e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 62.74  E-value: 3.99e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925063  469 HSGAVEAVAVSPLTYLMATTALDCSVRIYDFASKTLLTQMKFKQGG-TALVWVPRmvnftGAEIIVGFEDGVVRVLELYD 547
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPvRDVAASAD-----GTYLASGSSDKTIRLWDLET 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925063  548 PKGLTIFVGrkkisdadirlkqvfkpHTARVTALAYERDGEILATGSKDQTVFFFEVErDYKPIGYINT-PGPVCQLMWS 626
Cdd:cd00200    83 GECVRTLTG-----------------HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE-TGKCLTTLRGhTDWVNSVAFS 144


                  ....*
gi 966925063  627 PMSHL 631
Cdd:cd00200   145 PDGTF 149
WD40 COG2319
WD40 repeat [General function prediction only];
169-302 3.95e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.98  E-value: 3.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925063  169 NLKTKEQIYLRSSSGEGIGVIGVHPHKTYFIVAekGSFPDIIIYEYPSLRPYRILRDGTEKGYAyVNFNYSGTLLASVGS 248
Cdd:COG2319   274 DLATGELLRTLTGHSGGVNSVAFSPDGKLLASG--SDDGTVRLWDLATGKLLRTLTGHTGAVRS-VAFSPDGKTLASGSD 350

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 966925063  249 npDYTLTIWNWKEEQPILRTKAFSQEVFKVTFNPDNEEQLTTSGSGHIKFWEMA 302
Cdd:COG2319   351 --DGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 566-603 4.19e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 4.19e-05
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 966925063    566 RLKQVFKPHTARVTALAYERDGEILATGSKDQTVFFFE 603
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
566-603 1.15e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 1.15e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 966925063   566 RLKQVFKPHTARVTALAYERDGEILATGSKDQTVFFFE 603
Cdd:pfam00400    2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 567-639 1.43e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.40  E-value: 1.43e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966925063  567 LKQVFKPHTARVTALAYERDGEILATGSKDQTVFFFEVERDYKPIGYINTPGPVCQLMWSPmshlESTLLIIC 639
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASA----DGTYLASG 69
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 560-606 1.44e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 42.75  E-value: 1.44e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 966925063   560 ISDADIRLKQVFKPHTARVTALAYERDGEILATGSKDQTVFFFEVER 606
Cdd:pfam20426  109 ISLNDGRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVLR 155
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 459-498 1.45e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 1.45e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 966925063    459 TQDPECLFSFHSGAVEAVAVSPLTYLMATTALDCSVRIYD 498
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00121 PTZ00121
MAEBL; Provisional
 917-1229 1.47e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.59  E-value: 1.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925063  917 EDPKAYSIENARRKREHDKLMKEVEEIKAQkrEQIKALRTEFCKLLEMNEELPTHMQFKRTDFDVDSKIRAEMHRRTAFK 996
Cdd:PTZ00121 1508 AKKKADEAKKAEEAKKADEAKKAEEAKKAD--EAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEE 1585

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925063  997 IQQVEKELAWEKEKHELGLKKLKNRFRDPLESDTIVVHAILSDHKISSYRLVQPSKYSKFKRTSQSERKPSKLDRFEKEG 1076
Cdd:PTZ00121 1586 AKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAE 1665

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925063 1077 TGRKDSQRDAGGSIAIQEESiiEKGKKfrpktlseimvENQIEKTRKLILKAERAQLKIQQRKKEWEELYKSkpgDDYED 1156
Cdd:PTZ00121 1666 EAKKAEEDKKKAEEAKKAEE--DEKKA-----------AEALKKEAEEAKKAEELKKKEAEEKKKAEELKKA---EEENK 1729

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966925063 1157 PKDLQAIKEAQvymgdfnlktaPDYKIPEHMRINAAKKEEelghldslVHGNKRYMNKCILSLRDLKVAVVEE 1229
Cdd:PTZ00121 1730 IKAEEAKKEAE-----------EDKKKAEEAKKDEEEKKK--------IAHLKKEEEKKAEEIRKEKEAVIEE 1783
WD40 pfam00400
WD domain, G-beta repeat;
463-498 7.30e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.78  E-value: 7.30e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 966925063   463 ECLFSF--HSGAVEAVAVSPLTYLMATTALDCSVRIYD 498
Cdd:pfam00400    2 KLLKTLegHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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