|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
234-599 |
3.26e-24 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 107.30 E-value: 3.26e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 234 VNFNYSGTLLASVGSnpDYTLTIWNWKEEQPILRTKAFSQEVFKVTFNPDNEEQLTTSGSGHIKFWEMAftfTGLKLQGS 313
Cdd:COG2319 84 VAFSPDGRLLASASA--DGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA---TGKLLRTL 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 314 LGRFGKTTTTDIegymeLPDGKVL-SGSEWGNMLLWE---GGLIKVelCRGtskscHNGPINQIML--DEGEVITVGSDG 387
Cdd:COG2319 159 TGHSGAVTSVAF-----SPDGKLLaSGSDDGTVRLWDlatGKLLRT--LTG-----HTGAVRSVAFspDGKLLASGSADG 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 388 CVRIWDFETidtadiidetGlleiEPINELQVDKNVNL---FSmtkmsetGNNFWLA---QDANGAIWKLDlsfsniTQD 461
Cdd:COG2319 227 TVRLWDLAT----------G----KLLRTLTGHSGSVRsvaFS-------PDGRLLAsgsADGTVRLWDLA------TGE 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 462 PECLFSFHSGAVEAVAVSPLTYLMATTALDCSVRIYDFASKTLLTQMKFKQGG-TALVWVPrmvnfTGAEIIVGFEDGVV 540
Cdd:COG2319 280 LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAvRSVAFSP-----DGKTLASGSDDGTV 354
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 966925061 541 RVLELYDPKGLTIFVGrkkisdadirlkqvfkpHTARVTALAYERDGEILATGSKDQTV 599
Cdd:COG2319 355 RLWDLATGELLRTLTG-----------------HTGAVTSVAFSPDGRTLASGSADGTV 396
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
234-599 |
1.34e-21 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 97.02 E-value: 1.34e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 234 VNFNYSGTLLASVGSnpDYTLTIWNWKEEQPILRTKAFSQEVFKVTFNPDNEEQLTTSGSGHIKFW-----EMAFTFTGL 308
Cdd:cd00200 15 VAFSPDGKLLATGSG--DGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWdletgECVRTLTGH 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 309 KLQGSLGRFgkttttdiegymeLPDGKVLSGSEW-GNMLLWEggLIKVELCrgTSKSCHNGPINQI-MLDEGEVITVGS- 385
Cdd:cd00200 93 TSYVSSVAF-------------SPDGRILSSSSRdKTIKVWD--VETGKCL--TTLRGHTDWVNSVaFSPDGTFVASSSq 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 386 DGCVRIWDFETIdtadiidetglleiepinelqvdknvnlfsmtkmsetgnnfwlaqdangaiwkldlsfsnitqdpECL 465
Cdd:cd00200 156 DGTIKLWDLRTG-----------------------------------------------------------------KCV 170
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 466 --FSFHSGAVEAVAVSPLTYLMATTALDCSVRIYDFASKTLLTQMKFKQGG-TALVWvprmvNFTGAEIIVGFEDGVVRV 542
Cdd:cd00200 171 atLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGvNSVAF-----SPDGYLLASGSEDGTIRV 245
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 966925061 543 lelYDpkgltifvGRKKisdadiRLKQVFKPHTARVTALAYERDGEILATGSKDQTV 599
Cdd:cd00200 246 ---WD--------LRTG------ECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTI 285
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
1411-1692 |
4.49e-07 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 54.94 E-value: 4.49e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 1411 LTLQLREKRLDIEEALVEekkvVDNLKKEYDTLSKKVKIVATNLNAAEEALEAYQREKQQRLNELLVVIpLKLHQIeyvv 1490
Cdd:COG1196 216 RELKEELKELEAELLLLK----LRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELE-LELEEA---- 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 1491 fgeipsdlsgtlvfsNHALRRLQERIRELQEENSKQQKLNKEWRERRKQLIREKREMTKTIHKMEETVRQLmiskfgrvv 1570
Cdd:COG1196 287 ---------------QAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEEL--------- 342
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 1571 NLEALQTLSVNTTLEELKIRKLRKELANAKEMKMWEEKIAQMRWELMMKTKEHTRKLYQMNDLCIEKKKLDSRLNTLQNQ 1650
Cdd:COG1196 343 EEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEE 422
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 966925061 1651 QGNAFQSLREADVVAREEVTELIQLQAERISALKEEIALLRR 1692
Cdd:COG1196 423 LEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLEL 464
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
1406-1693 |
1.11e-05 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 50.44 E-value: 1.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 1406 VALFELTLQLREKRLDIEEA---LVEEKKVVDNLKKEYDTLSKKVKIVATNLNAAEEALEAYQREKQQrLNELLVVIPLK 1482
Cdd:TIGR02168 705 KELEELEEELEQLRKELEELsrqISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEE-AEEELAEAEAE 783
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 1483 LHQIEYVVfgeipSDLSGTLVFSNHALRRLQERIRELQEENSKQQklnkewrERRKQLIREKREMTKTIHKMEETVRQLm 1562
Cdd:TIGR02168 784 IEELEAQI-----EQLKEELKALREALDELRAELTLLNEEAANLR-------ERLESLERRIAATERRLEDLEEQIEEL- 850
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 1563 iskfgrvvnLEALQTLSVNTTLEELKIRKLRKELANA-KEMKMWEEKIAQMRWE---LMMKTKEHTRKLYQMNDLCIEKK 1638
Cdd:TIGR02168 851 ---------SEDIESLAAEIEELEELIEELESELEALlNERASLEEALALLRSEleeLSEELRELESKRSELRRELEELR 921
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 966925061 1639 ----KLDSRLNTLQNQQGNAFQSLREADVVAREEVTELIQLQAERISALKEEIALLRRK 1693
Cdd:TIGR02168 922 eklaQLELRLEGLEVRIDNLQERLSEEYSLTLEEAEALENKIEDDEEEARRRLKRLENK 980
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
566-603 |
4.65e-05 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 41.91 E-value: 4.65e-05
10 20 30
....*....|....*....|....*....|....*...
gi 966925061 566 RLKQVFKPHTARVTALAYERDGEILATGSKDQTVFFFE 603
Cdd:smart00320 3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
566-603 |
1.27e-04 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 40.79 E-value: 1.27e-04
10 20 30
....*....|....*....|....*....|....*...
gi 966925061 566 RLKQVFKPHTARVTALAYERDGEILATGSKDQTVFFFE 603
Cdd:pfam00400 2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
567-639 |
1.60e-04 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 45.40 E-value: 1.60e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966925061 567 LKQVFKPHTARVTALAYERDGEILATGSKDQTVFFFEVERDYKPIGYINTPGPVCQLMWSPmshlESTLLIIC 639
Cdd:cd00200 1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASA----DGTYLASG 69
|
|
| SMC_N |
pfam02463 |
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ... |
777-1693 |
2.04e-04 |
|
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.
Pssm-ID: 426784 [Multi-domain] Cd Length: 1161 Bit Score: 46.50 E-value: 2.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 777 IEDPKAYSIENARRKREHDKLMKEVEEIKAQKREQIKALRTEFcKLLEMNEELPTHMQFKRTDFDVDSKIRAEmhrrtaf 856
Cdd:pfam02463 158 IEEEAAGSRLKRKKKEALKKLIEETENLAELIIDLEELKLQEL-KLKEQAKKALEYYQLKEKLELEEEYLLYL------- 229
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 857 KIQQVEKElaWEKEKHELGLKKLKnrfrdplesdtivvhailsdhKISSYRLVQPSKYSKFKRTSQSERKPSKLDRFEKE 936
Cdd:pfam02463 230 DYLKLNEE--RIDLLQELLRDEQE---------------------EIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEE 286
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 937 GTGRKDSQRDAGGSIAIQEESIIEKGKkfRPKTLSEIMVENQIEKTRKLILKAERAQ--LKIQQRKKEWEELYKSKPGDD 1014
Cdd:pfam02463 287 ELKLLAKEEEELKSELLKLERRKVDDE--EKLKESEKEKKKAEKELKKEKEEIEELEkeLKELEIKREAEEEEEEELEKL 364
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 1015 YE-DPKDLQAIKEAQVYMGDFNLKTAPDYKIPEHMRINAAKKEEELGHLDSlvhgNKRYMNKCILSLRDLKVAVVEEIQC 1093
Cdd:pfam02463 365 QEkLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELAR----QLEDLLKEEKKEELEILEEEEESIE 440
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 1094 LVQELKNIQST-LHVSKHIpipQIPQIHPEEVPEKRFQYDEETLLNFKQQHMKSD-DEKSPGVEQTGSGGPGGGFLKLSS 1171
Cdd:pfam02463 441 LKQGKLTEEKEeLEKQELK---LLKDELELKKSEDLLKETQLVKLQEQLELLLSRqKLEERSQKESKARSGLKVLLALIK 517
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 1172 GKDGDLTTRDSMSRSSKASTLSLDIPKYMEFEKAEPTDVELEIMKRDEIKHVYMQQYLVNRVKELIVTFDAELRLLRHQK 1251
Cdd:pfam02463 518 DGVGGRIISAHGRLGDLGVAVENYKVAISTAVIVEVSATADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVL 597
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 1252 LKLDTQMKLSDLHHVTLFQEI----LLLKNFEKQENILQERVNSLDKEEQYMQWKINETLKEMEEKKNEITKLQEQEKAL 1327
Cdd:pfam02463 598 EIDPILNLAQLDKATLEADEDdkraKVVEGILKDTELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLE 677
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 1328 YAGFQTAIGENNKFANFLMKVLKKKIKRVKKKEVEGDADEDEESEESSEEESSLESDEDESESEDEVFDDSICPTNCDVA 1407
Cdd:pfam02463 678 IQELQEKAESELAKEEILRRQLEIKKKEQREKEELKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRL 757
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 1408 LFELTLQLREKRLDIEEALvEEKKVVDNLKKEYDTLSKKVKIVATNLNAAEEALEAYQREKQQRLNELLVVIPLKLHQIE 1487
Cdd:pfam02463 758 KKEEKEEEKSELSLKEKEL-AEEREKTEKLKVEEEKEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELE 836
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 1488 YvvfgeipsdLSGTLVFSNHALRRLQERIRELQEENSKQQKLNKEWRERRKQLIREKREMTKTIHKMEETVRQlmiskfg 1567
Cdd:pfam02463 837 E---------LALELKEEQKLEKLAEEELERLEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKK------- 900
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 1568 rvvnlEALQTLSVNTTLEELKIRKLRKELANAKEMKMWEEkiaqmrWELMMKTKEHTRKLYQMNDLCIEKKKLDSRLNTL 1647
Cdd:pfam02463 901 -----ELEEESQKLNLLEEKENEIEERIKEEAEILLKYEE------EPEELLLEEADEKEKEENNKEEEEERNKRLLLAK 969
|
890 900 910 920
....*....|....*....|....*....|....*....|....*....
gi 966925061 1648 Q---NQQGNAFQSLREADVVAREEVTELIQLQAERISALKEEIALLRRK 1693
Cdd:pfam02463 970 EelgKVNLMAIEEFEEKEERYNKDELEKERLEEEKKKLIRAIIEETCQR 1018
|
|
| PRK03918 |
PRK03918 |
DNA double-strand break repair ATPase Rad50; |
1410-1688 |
3.75e-03 |
|
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 41.97 E-value: 3.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 1410 ELTLQLREKRLDIEEALVEEKKVVDNLKKEYDTLSKKVKI-----VATNLNAAEEALEAYQREKQQRLNELLVVIPLKLH 1484
Cdd:PRK03918 456 EYTAELKRIEKELKEIEEKERKLRKELRELEKVLKKESELiklkeLAEQLKELEEKLKKYNLEELEKKAEEYEKLKEKLI 535
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 1485 QIEyvvfGEIpsdlsgtlvfsnhalRRLQERIRELQEENSKQQKLNKEWR---ERRKQLIREKREMT-KTIHKMEETVRQ 1560
Cdd:PRK03918 536 KLK----GEI---------------KSLKKELEKLEELKKKLAELEKKLDeleEELAELLKELEELGfESVEELEERLKE 596
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 1561 L--MISKFGRVVN----LEALQTL--SVNTTLEEL---------KIRKLRKELaNAKEMKMWEEKIAQMRWELMMKTKEH 1623
Cdd:PRK03918 597 LepFYNEYLELKDaekeLEREEKElkKLEEELDKAfeelaetekRLEELRKEL-EELEKKYSEEEYEELREEYLELSREL 675
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966925061 1624 TRKLYQMNDLCIEKKKLDSRLNTLQNQQGNAFQSLREADVV--AREEVTELIqlqaERISALKEEIA 1688
Cdd:PRK03918 676 AGLRAELEELEKRREEIKKTLEKLKEELEEREKAKKELEKLekALERVEELR----EKVKKYKALLK 738
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
778-1090 |
8.36e-03 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 41.28 E-value: 8.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 778 EDPKAYSIENARRKREHDKLMKEVEEIKAQkrEQIKALRTEFCKLLEMNEELPTHMQFKRTDFDVDSKIRAEMHRRTAFK 857
Cdd:PTZ00121 1508 AKKKADEAKKAEEAKKADEAKKAEEAKKAD--EAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEE 1585
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 858 IQQVEKELAWEKEKHELGLKKLKNRFRDPLESDTIVVHAILSDHKISSYRLVQPSKYSKFKRTSQSERKPSKLDRFEKEG 937
Cdd:PTZ00121 1586 AKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAE 1665
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 938 TGRKDSQRDAGGSIAIQEESiiEKGKKfrpktlseimvENQIEKTRKLILKAERAQLKIQQRKKEWEELYKSkpgDDYED 1017
Cdd:PTZ00121 1666 EAKKAEEDKKKAEEAKKAEE--DEKKA-----------AEALKKEAEEAKKAEELKKKEAEEKKKAEELKKA---EEENK 1729
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966925061 1018 PKDLQAIKEAQvymgdfnlktaPDYKIPEHMRINAAKKEEelghldslVHGNKRYMNKCILSLRDLKVAVVEE 1090
Cdd:PTZ00121 1730 IKAEEAKKEAE-----------EDKKKAEEAKKDEEEKKK--------IAHLKKEEEKKAEEIRKEKEAVIEE 1783
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
234-599 |
3.26e-24 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 107.30 E-value: 3.26e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 234 VNFNYSGTLLASVGSnpDYTLTIWNWKEEQPILRTKAFSQEVFKVTFNPDNEEQLTTSGSGHIKFWEMAftfTGLKLQGS 313
Cdd:COG2319 84 VAFSPDGRLLASASA--DGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA---TGKLLRTL 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 314 LGRFGKTTTTDIegymeLPDGKVL-SGSEWGNMLLWE---GGLIKVelCRGtskscHNGPINQIML--DEGEVITVGSDG 387
Cdd:COG2319 159 TGHSGAVTSVAF-----SPDGKLLaSGSDDGTVRLWDlatGKLLRT--LTG-----HTGAVRSVAFspDGKLLASGSADG 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 388 CVRIWDFETidtadiidetGlleiEPINELQVDKNVNL---FSmtkmsetGNNFWLA---QDANGAIWKLDlsfsniTQD 461
Cdd:COG2319 227 TVRLWDLAT----------G----KLLRTLTGHSGSVRsvaFS-------PDGRLLAsgsADGTVRLWDLA------TGE 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 462 PECLFSFHSGAVEAVAVSPLTYLMATTALDCSVRIYDFASKTLLTQMKFKQGG-TALVWVPrmvnfTGAEIIVGFEDGVV 540
Cdd:COG2319 280 LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAvRSVAFSP-----DGKTLASGSDDGTV 354
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 966925061 541 RVLELYDPKGLTIFVGrkkisdadirlkqvfkpHTARVTALAYERDGEILATGSKDQTV 599
Cdd:COG2319 355 RLWDLATGELLRTLTG-----------------HTGAVTSVAFSPDGRTLASGSADGTV 396
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
234-599 |
1.34e-21 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 97.02 E-value: 1.34e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 234 VNFNYSGTLLASVGSnpDYTLTIWNWKEEQPILRTKAFSQEVFKVTFNPDNEEQLTTSGSGHIKFW-----EMAFTFTGL 308
Cdd:cd00200 15 VAFSPDGKLLATGSG--DGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWdletgECVRTLTGH 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 309 KLQGSLGRFgkttttdiegymeLPDGKVLSGSEW-GNMLLWEggLIKVELCrgTSKSCHNGPINQI-MLDEGEVITVGS- 385
Cdd:cd00200 93 TSYVSSVAF-------------SPDGRILSSSSRdKTIKVWD--VETGKCL--TTLRGHTDWVNSVaFSPDGTFVASSSq 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 386 DGCVRIWDFETIdtadiidetglleiepinelqvdknvnlfsmtkmsetgnnfwlaqdangaiwkldlsfsnitqdpECL 465
Cdd:cd00200 156 DGTIKLWDLRTG-----------------------------------------------------------------KCV 170
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 466 --FSFHSGAVEAVAVSPLTYLMATTALDCSVRIYDFASKTLLTQMKFKQGG-TALVWvprmvNFTGAEIIVGFEDGVVRV 542
Cdd:cd00200 171 atLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGvNSVAF-----SPDGYLLASGSEDGTIRV 245
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 966925061 543 lelYDpkgltifvGRKKisdadiRLKQVFKPHTARVTALAYERDGEILATGSKDQTV 599
Cdd:cd00200 246 ---WD--------LRTG------ECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTI 285
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
238-627 |
1.57e-21 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 99.22 E-value: 1.57e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 238 YSGTLLASVGSNPDYTLTIWNWKEEQPILRTKAFSQEVFKVTFNPDNEEQLTTSGSGHIKFWEMAftfTGLKLQGSLGRF 317
Cdd:COG2319 44 ASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLA---TGLLLRTLTGHT 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 318 GKTTTTDIEgymelPDGK-VLSGSEWGNMLLWE---GGLIKVelcrgtsKSCHNGPINQIML--DEGEVITVGSDGCVRI 391
Cdd:COG2319 121 GAVRSVAFS-----PDGKtLASGSADGTVRLWDlatGKLLRT-------LTGHSGAVTSVAFspDGKLLASGSDDGTVRL 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 392 WDFETidtadiidetGlleiEPINELQVDKNVnLFSMTkMSETGNnfWLA---QDANGAIWKLDlsfsniTQDPECLFSF 468
Cdd:COG2319 189 WDLAT----------G----KLLRTLTGHTGA-VRSVA-FSPDGK--LLAsgsADGTVRLWDLA------TGKLLRTLTG 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 469 HSGAVEAVAVSPLTYLMATTALDCSVRIYDFASKTLLTQMKFKQGG-TALVWVPrmvnfTGAEIIVGFEDGVVRVLELyd 547
Cdd:COG2319 245 HSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGvNSVAFSP-----DGKLLASGSDDGTVRLWDL-- 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 548 pkgltifvgrkkisdADIRLKQVFKPHTARVTALAYERDGEILATGSKDQTVFFFEVERDYKPIGYINTPGPVCQLMWSP 627
Cdd:COG2319 318 ---------------ATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP 382
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
209-498 |
3.05e-19 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 90.09 E-value: 3.05e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 209 IIIYEYPSLRPYRILRdGTEKGYAYVNFNYSGTLLASVGSnpDYTLTIWNWKEEQPILRTKAFSQEVFKVTFNPDNEEQL 288
Cdd:cd00200 33 IKVWDLETGELLRTLK-GHTGPVRDVAASADGTYLASGSS--DKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILS 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 289 TTSGSGHIKFWEMA-----FTFTGLKLQGSLGRFgkttttdiegymeLPDGKVLSGSEW-GNMLLWEGGLIKvelCRGTS 362
Cdd:cd00200 110 SSSRDKTIKVWDVEtgkclTTLRGHTDWVNSVAF-------------SPDGTFVASSSQdGTIKLWDLRTGK---CVATL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 363 KScHNGPINQIML--DEGEVITVGSDGCVRIWDFETIDTadiideTGLLEI--EPINELQVDKNVNLFSmtkmsetgnnf 438
Cdd:cd00200 174 TG-HTGEVNSVAFspDGEKLLSSSSDGTIKLWDLSTGKC------LGTLRGheNGVNSVAFSPDGYLLA----------- 235
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966925061 439 wlAQDANGAI--WKLDlsfsnitqDPECLFSF--HSGAVEAVAVSPLTYLMATTALDCSVRIYD 498
Cdd:cd00200 236 --SGSEDGTIrvWDLR--------TGECVQTLsgHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
332-627 |
8.89e-19 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 88.55 E-value: 8.89e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 332 PDGKVL-SGSEWGNMLLW--EGGLIKVELCrGtskscHNGPINQIML--DEGEVITVGSDGCVRIWDFETIdtadiidet 406
Cdd:cd00200 19 PDGKLLaTGSGDGTIKVWdlETGELLRTLK-G-----HTGPVRDVAAsaDGTYLASGSSDKTIRLWDLETG--------- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 407 glleiEPINELQVDKNvNLFSMTKMSetgNNFWLA---QDANGAIWKLDlsfsnitqDPECLFSF--HSGAVEAVAVSPL 481
Cdd:cd00200 84 -----ECVRTLTGHTS-YVSSVAFSP---DGRILSsssRDKTIKVWDVE--------TGKCLTTLrgHTDWVNSVAFSPD 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 482 TYLMATTALDCSVRIYDFASKTLLTQMKFKQGG-TALVWVPrmvnfTGAEIIVGFEDGVVRVLELYDPKgltifvgrkki 560
Cdd:cd00200 147 GTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEvNSVAFSP-----DGEKLLSSSSDGTIKLWDLSTGK----------- 210
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966925061 561 sdadirLKQVFKPHTARVTALAYERDGEILATGSKDQTVFFFEVERDYKPIGYINTPGPVCQLMWSP 627
Cdd:cd00200 211 ------CLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP 271
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
239-627 |
1.38e-14 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 78.03 E-value: 1.38e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 239 SGTLLASVGSNPDYTLTIWNWKEEQPILRTKAFSQEVFKVTFNPDNEEQLTTSGSGHIKFWEMAFTFTGLKLQGSLGRfg 318
Cdd:COG2319 3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA-- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 319 kttttdIEGYMELPDGKVL-SGSEWGNMLLW--EGGLIKVELcrgtskSCHNGPINQIML--DEGEVITVGSDGCVRIWD 393
Cdd:COG2319 81 ------VLSVAFSPDGRLLaSASADGTVRLWdlATGLLLRTL------TGHTGAVRSVAFspDGKTLASGSADGTVRLWD 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 394 fetidtadiidetglleiepinelqvdknvnlfsmtkmsetgnnfwlaqdangaiwkldlsfsniTQDPECLFSF--HSG 471
Cdd:COG2319 149 -----------------------------------------------------------------LATGKLLRTLtgHSG 163
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 472 AVEAVAVSPLTYLMATTALDCSVRIYDFASKTLLTQMKfkqGGTALVWVprmVNFT--GAEIIVGFEDGVVRVLELYDPK 549
Cdd:COG2319 164 AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT---GHTGAVRS---VAFSpdGKLLASGSADGTVRLWDLATGK 237
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966925061 550 GLTIFVGrkkisdadirlkqvfkpHTARVTALAYERDGEILATGSKDQTVFFFEVErDYKPIGYINTP-GPVCQLMWSP 627
Cdd:COG2319 238 LLRTLTG-----------------HSGSVRSVAFSPDGRLLASGSADGTVRLWDLA-TGELLRTLTGHsGGVNSVAFSP 298
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
158-393 |
1.12e-11 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 67.36 E-value: 1.12e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 158 IYIAG--NQLIFLNLKTKEQIylRSSSGEGIGVIGVHPHKTYFIVAekGSFPD--IIIYEYPSLRPYRILRdGTEKGYAY 233
Cdd:cd00200 66 LASGSsdKTIRLWDLETGECV--RTLTGHTSYVSSVAFSPDGRILS--SSSRDktIKVWDVETGKCLTTLR-GHTDWVNS 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 234 VNFNYSGTLLASVGSnpDYTLTIWNWKEEQPILRTKAFSQEVFKVTFNPDNEEQLTTSGSGHIKFWEMAFTFTGLKLQGS 313
Cdd:cd00200 141 VAFSPDGTFVASSSQ--DGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGH 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 314 LGRFgktTTTDIegymeLPDGK-VLSGSEWGNMLLWegglikvELCRGTSKSC---HNGPINQIML--DEGEVITVGSDG 387
Cdd:cd00200 219 ENGV---NSVAF-----SPDGYlLASGSEDGTIRVW-------DLRTGECVQTlsgHTNSVTSLAWspDGKRLASGSADG 283
|
....*.
gi 966925061 388 CVRIWD 393
Cdd:cd00200 284 TIRIWD 289
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
234-396 |
2.54e-11 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 67.63 E-value: 2.54e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 234 VNFNYSGTLLASVGSnpDYTLTIWNWKEEQPILRTKAFSQEVFKVTFNPDNEeQL-TTSGSGHIKFWEMAftfTGLKLQG 312
Cdd:COG2319 252 VAFSPDGRLLASGSA--DGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGK-LLaSGSDDGTVRLWDLA---TGKLLRT 325
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 313 SLGRFGKTTTTDIegymeLPDGKVL-SGSEWGNMLLW--EGGLIKVELcRGtskscHNGPINQIML--DEGEVITVGSDG 387
Cdd:COG2319 326 LTGHTGAVRSVAF-----SPDGKTLaSGSDDGTVRLWdlATGELLRTL-TG-----HTGAVTSVAFspDGRTLASGSADG 394
|
....*....
gi 966925061 388 CVRIWDFET 396
Cdd:COG2319 395 TVRLWDLAT 403
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
209-396 |
2.80e-11 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 67.63 E-value: 2.80e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 209 IIIYEYPSLRPYRILRDGTEKGYAyVNFNYSGTLLASVGSnpDYTLTIWNWKEEQPILRTKAFSQEVFKVTFNPDNeEQL 288
Cdd:COG2319 186 VRLWDLATGKLLRTLTGHTGAVRS-VAFSPDGKLLASGSA--DGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDG-RLL 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 289 -TTSGSGHIKFWEMAftfTGLKLQGSLGRFGKTTTTDIegymeLPDGKVL-SGSEWGNMLLWEGGLIKvelCRGTSKScH 366
Cdd:COG2319 262 aSGSADGTVRLWDLA---TGELLRTLTGHSGGVNSVAF-----SPDGKLLaSGSDDGTVRLWDLATGK---LLRTLTG-H 329
|
170 180 190
....*....|....*....|....*....|..
gi 966925061 367 NGPINQIML--DEGEVITVGSDGCVRIWDFET 396
Cdd:COG2319 330 TGAVRSVAFspDGKTLASGSDDGTVRLWDLAT 361
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
469-631 |
4.48e-10 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 62.74 E-value: 4.48e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 469 HSGAVEAVAVSPLTYLMATTALDCSVRIYDFASKTLLTQMKFKQGG-TALVWVPRmvnftGAEIIVGFEDGVVRVLELYD 547
Cdd:cd00200 8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPvRDVAASAD-----GTYLASGSSDKTIRLWDLET 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 548 PKGLTIFVGrkkisdadirlkqvfkpHTARVTALAYERDGEILATGSKDQTVFFFEVErDYKPIGYINT-PGPVCQLMWS 626
Cdd:cd00200 83 GECVRTLTG-----------------HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE-TGKCLTTLRGhTDWVNSVAFS 144
|
....*
gi 966925061 627 PMSHL 631
Cdd:cd00200 145 PDGTF 149
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
1411-1692 |
4.49e-07 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 54.94 E-value: 4.49e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 1411 LTLQLREKRLDIEEALVEekkvVDNLKKEYDTLSKKVKIVATNLNAAEEALEAYQREKQQRLNELLVVIpLKLHQIeyvv 1490
Cdd:COG1196 216 RELKEELKELEAELLLLK----LRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELE-LELEEA---- 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 1491 fgeipsdlsgtlvfsNHALRRLQERIRELQEENSKQQKLNKEWRERRKQLIREKREMTKTIHKMEETVRQLmiskfgrvv 1570
Cdd:COG1196 287 ---------------QAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEEL--------- 342
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 1571 NLEALQTLSVNTTLEELKIRKLRKELANAKEMKMWEEKIAQMRWELMMKTKEHTRKLYQMNDLCIEKKKLDSRLNTLQNQ 1650
Cdd:COG1196 343 EEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEE 422
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 966925061 1651 QGNAFQSLREADVVAREEVTELIQLQAERISALKEEIALLRR 1692
Cdd:COG1196 423 LEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLEL 464
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
1406-1693 |
1.11e-05 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 50.44 E-value: 1.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 1406 VALFELTLQLREKRLDIEEA---LVEEKKVVDNLKKEYDTLSKKVKIVATNLNAAEEALEAYQREKQQrLNELLVVIPLK 1482
Cdd:TIGR02168 705 KELEELEEELEQLRKELEELsrqISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEE-AEEELAEAEAE 783
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 1483 LHQIEYVVfgeipSDLSGTLVFSNHALRRLQERIRELQEENSKQQklnkewrERRKQLIREKREMTKTIHKMEETVRQLm 1562
Cdd:TIGR02168 784 IEELEAQI-----EQLKEELKALREALDELRAELTLLNEEAANLR-------ERLESLERRIAATERRLEDLEEQIEEL- 850
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 1563 iskfgrvvnLEALQTLSVNTTLEELKIRKLRKELANA-KEMKMWEEKIAQMRWE---LMMKTKEHTRKLYQMNDLCIEKK 1638
Cdd:TIGR02168 851 ---------SEDIESLAAEIEELEELIEELESELEALlNERASLEEALALLRSEleeLSEELRELESKRSELRRELEELR 921
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 966925061 1639 ----KLDSRLNTLQNQQGNAFQSLREADVVAREEVTELIQLQAERISALKEEIALLRRK 1693
Cdd:TIGR02168 922 eklaQLELRLEGLEVRIDNLQERLSEEYSLTLEEAEALENKIEDDEEEARRRLKRLENK 980
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
1414-1699 |
3.26e-05 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 48.22 E-value: 3.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 1414 QLREKRLDIEEALVEEKKVVDNLKKEYDTLSKKVKIVATNLNAAEEALEAYQREkqqrlnellvviplklhqieyvvfge 1493
Cdd:COG4942 24 EAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQE-------------------------- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 1494 ipsdlsgtlvfsnhaLRRLQERIRELQEEnskQQKLNKEWRERRKQLirekREMTKTIHKMEETVRQLMI----SKFGRV 1569
Cdd:COG4942 78 ---------------LAALEAELAELEKE---IAELRAELEAQKEEL----AELLRALYRLGRQPPLALLlspeDFLDAV 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 1570 VNLEALQTLSVNTTLEELKIRKLRKELANAKEmkmweeKIAQMRWELMMKTKEHTRKLYQMNDLCIEKKKLDSRLNTLQN 1649
Cdd:COG4942 136 RRLQYLKYLAPARREQAEELRADLAELAALRA------ELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELA 209
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 966925061 1650 QQGNAFQSLREADVVAREEVTELIQLQAERiSALKEEIALLRRKGGLILP 1699
Cdd:COG4942 210 ELAAELAELQQEAEELEALIARLEAEAAAA-AERTPAAGFAALKGKLPWP 258
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
169-302 |
4.43e-05 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 47.98 E-value: 4.43e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 169 NLKTKEQIYLRSSSGEGIGVIGVHPHKTYFIVAekGSFPDIIIYEYPSLRPYRILRDGTEKGYAyVNFNYSGTLLASVGS 248
Cdd:COG2319 274 DLATGELLRTLTGHSGGVNSVAFSPDGKLLASG--SDDGTVRLWDLATGKLLRTLTGHTGAVRS-VAFSPDGKTLASGSD 350
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 966925061 249 npDYTLTIWNWKEEQPILRTKAFSQEVFKVTFNPDNEEQLTTSGSGHIKFWEMA 302
Cdd:COG2319 351 --DGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
566-603 |
4.65e-05 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 41.91 E-value: 4.65e-05
10 20 30
....*....|....*....|....*....|....*...
gi 966925061 566 RLKQVFKPHTARVTALAYERDGEILATGSKDQTVFFFE 603
Cdd:smart00320 3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
1414-1653 |
4.86e-05 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 48.51 E-value: 4.86e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 1414 QLREKRLDIEEALVEEKKVVDNLKKEYDTLSKKVKIVA---TNLNAAEEALEAYQREKQQRLNELLvvipLKLHQIEYvv 1490
Cdd:TIGR02168 271 ELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRerlANLERQLEELEAQLEELESKLDELA----EELAELEE-- 344
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 1491 fgeipsDLSGTLVFSNHALRRLQERIRELQEENSKQQKLNKEWRERRKQLIREKREMT---KTIHKMEETVRQLMiskfG 1567
Cdd:TIGR02168 345 ------KLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIAslnNEIERLEARLERLE----D 414
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 1568 RVVNLEAlQTLSVNTTLEELKIRKLRKELANAKEM-KMWEEKIAQMRWELMMKTKEHTRKLYQMNDLCIEKKKLDSRLNT 1646
Cdd:TIGR02168 415 RRERLQQ-EIEELLKKLEEAELKELQAELEELEEElEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDS 493
|
....*..
gi 966925061 1647 LQNQQGN 1653
Cdd:TIGR02168 494 LERLQEN 500
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
566-603 |
1.27e-04 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 40.79 E-value: 1.27e-04
10 20 30
....*....|....*....|....*....|....*...
gi 966925061 566 RLKQVFKPHTARVTALAYERDGEILATGSKDQTVFFFE 603
Cdd:pfam00400 2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
567-639 |
1.60e-04 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 45.40 E-value: 1.60e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966925061 567 LKQVFKPHTARVTALAYERDGEILATGSKDQTVFFFEVERDYKPIGYINTPGPVCQLMWSPmshlESTLLIIC 639
Cdd:cd00200 1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASA----DGTYLASG 69
|
|
| SMC_N |
pfam02463 |
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ... |
777-1693 |
2.04e-04 |
|
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.
Pssm-ID: 426784 [Multi-domain] Cd Length: 1161 Bit Score: 46.50 E-value: 2.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 777 IEDPKAYSIENARRKREHDKLMKEVEEIKAQKREQIKALRTEFcKLLEMNEELPTHMQFKRTDFDVDSKIRAEmhrrtaf 856
Cdd:pfam02463 158 IEEEAAGSRLKRKKKEALKKLIEETENLAELIIDLEELKLQEL-KLKEQAKKALEYYQLKEKLELEEEYLLYL------- 229
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 857 KIQQVEKElaWEKEKHELGLKKLKnrfrdplesdtivvhailsdhKISSYRLVQPSKYSKFKRTSQSERKPSKLDRFEKE 936
Cdd:pfam02463 230 DYLKLNEE--RIDLLQELLRDEQE---------------------EIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEE 286
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 937 GTGRKDSQRDAGGSIAIQEESIIEKGKkfRPKTLSEIMVENQIEKTRKLILKAERAQ--LKIQQRKKEWEELYKSKPGDD 1014
Cdd:pfam02463 287 ELKLLAKEEEELKSELLKLERRKVDDE--EKLKESEKEKKKAEKELKKEKEEIEELEkeLKELEIKREAEEEEEEELEKL 364
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 1015 YE-DPKDLQAIKEAQVYMGDFNLKTAPDYKIPEHMRINAAKKEEELGHLDSlvhgNKRYMNKCILSLRDLKVAVVEEIQC 1093
Cdd:pfam02463 365 QEkLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELAR----QLEDLLKEEKKEELEILEEEEESIE 440
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 1094 LVQELKNIQST-LHVSKHIpipQIPQIHPEEVPEKRFQYDEETLLNFKQQHMKSD-DEKSPGVEQTGSGGPGGGFLKLSS 1171
Cdd:pfam02463 441 LKQGKLTEEKEeLEKQELK---LLKDELELKKSEDLLKETQLVKLQEQLELLLSRqKLEERSQKESKARSGLKVLLALIK 517
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 1172 GKDGDLTTRDSMSRSSKASTLSLDIPKYMEFEKAEPTDVELEIMKRDEIKHVYMQQYLVNRVKELIVTFDAELRLLRHQK 1251
Cdd:pfam02463 518 DGVGGRIISAHGRLGDLGVAVENYKVAISTAVIVEVSATADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVL 597
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 1252 LKLDTQMKLSDLHHVTLFQEI----LLLKNFEKQENILQERVNSLDKEEQYMQWKINETLKEMEEKKNEITKLQEQEKAL 1327
Cdd:pfam02463 598 EIDPILNLAQLDKATLEADEDdkraKVVEGILKDTELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLE 677
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 1328 YAGFQTAIGENNKFANFLMKVLKKKIKRVKKKEVEGDADEDEESEESSEEESSLESDEDESESEDEVFDDSICPTNCDVA 1407
Cdd:pfam02463 678 IQELQEKAESELAKEEILRRQLEIKKKEQREKEELKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRL 757
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 1408 LFELTLQLREKRLDIEEALvEEKKVVDNLKKEYDTLSKKVKIVATNLNAAEEALEAYQREKQQRLNELLVVIPLKLHQIE 1487
Cdd:pfam02463 758 KKEEKEEEKSELSLKEKEL-AEEREKTEKLKVEEEKEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELE 836
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 1488 YvvfgeipsdLSGTLVFSNHALRRLQERIRELQEENSKQQKLNKEWRERRKQLIREKREMTKTIHKMEETVRQlmiskfg 1567
Cdd:pfam02463 837 E---------LALELKEEQKLEKLAEEELERLEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKK------- 900
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 1568 rvvnlEALQTLSVNTTLEELKIRKLRKELANAKEMKMWEEkiaqmrWELMMKTKEHTRKLYQMNDLCIEKKKLDSRLNTL 1647
Cdd:pfam02463 901 -----ELEEESQKLNLLEEKENEIEERIKEEAEILLKYEE------EPEELLLEEADEKEKEENNKEEEEERNKRLLLAK 969
|
890 900 910 920
....*....|....*....|....*....|....*....|....*....
gi 966925061 1648 Q---NQQGNAFQSLREADVVAREEVTELIQLQAERISALKEEIALLRRK 1693
Cdd:pfam02463 970 EelgKVNLMAIEEFEEKEERYNKDELEKERLEEEKKKLIRAIIEETCQR 1018
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
459-498 |
1.60e-03 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 37.68 E-value: 1.60e-03
10 20 30 40
....*....|....*....|....*....|....*....|
gi 966925061 459 TQDPECLFSFHSGAVEAVAVSPLTYLMATTALDCSVRIYD 498
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| NBCH_WD40 |
pfam20426 |
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ... |
560-606 |
1.62e-03 |
|
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.
Pssm-ID: 466575 [Multi-domain] Cd Length: 350 Bit Score: 42.75 E-value: 1.62e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 966925061 560 ISDADIRLKQVFKPHTARVTALAYERDGEILATGSKDQTVFFFEVER 606
Cdd:pfam20426 109 ISLNDGRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVLR 155
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
1441-1661 |
1.68e-03 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 43.37 E-value: 1.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 1441 DTLSKKVKIVATNLNAAEEALEAYQREKQQRLNELLVviplkLHQIEYVVFGEIpsDLSGTLvfsnHALRRLQERIRELQ 1520
Cdd:COG4913 613 AALEAELAELEEELAEAEERLEALEAELDALQERREA-----LQRLAEYSWDEI--DVASAE----REIAELEAELERLD 681
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 1521 EENSKQQKLNKEW---RERRKQLIREKREMTKTIHKMEETVRQLmiskfgrvvnlealqtlsvnttleELKIRKLRKELA 1597
Cdd:COG4913 682 ASSDDLAALEEQLeelEAELEELEEELDELKGEIGRLEKELEQA------------------------EEELDELQDRLE 737
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966925061 1598 NAKEMKMWE--EKIAQMRWELMmkTKEHTRKLyqmndlcieKKKLDSRLNTLQNQQGNAFQSLREA 1661
Cdd:COG4913 738 AAEDLARLElrALLEERFAAAL--GDAVEREL---------RENLEERIDALRARLNRAEEELERA 792
|
|
| PRK03918 |
PRK03918 |
DNA double-strand break repair ATPase Rad50; |
1410-1688 |
3.75e-03 |
|
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 41.97 E-value: 3.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 1410 ELTLQLREKRLDIEEALVEEKKVVDNLKKEYDTLSKKVKI-----VATNLNAAEEALEAYQREKQQRLNELLVVIPLKLH 1484
Cdd:PRK03918 456 EYTAELKRIEKELKEIEEKERKLRKELRELEKVLKKESELiklkeLAEQLKELEEKLKKYNLEELEKKAEEYEKLKEKLI 535
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 1485 QIEyvvfGEIpsdlsgtlvfsnhalRRLQERIRELQEENSKQQKLNKEWR---ERRKQLIREKREMT-KTIHKMEETVRQ 1560
Cdd:PRK03918 536 KLK----GEI---------------KSLKKELEKLEELKKKLAELEKKLDeleEELAELLKELEELGfESVEELEERLKE 596
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 1561 L--MISKFGRVVN----LEALQTL--SVNTTLEEL---------KIRKLRKELaNAKEMKMWEEKIAQMRWELMMKTKEH 1623
Cdd:PRK03918 597 LepFYNEYLELKDaekeLEREEKElkKLEEELDKAfeelaetekRLEELRKEL-EELEKKYSEEEYEELREEYLELSREL 675
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966925061 1624 TRKLYQMNDLCIEKKKLDSRLNTLQNQQGNAFQSLREADVV--AREEVTELIqlqaERISALKEEIA 1688
Cdd:PRK03918 676 AGLRAELEELEKRREEIKKTLEKLKEELEEREKAKKELEKLekALERVEELR----EKVKKYKALLK 738
|
|
| SMC_N |
pfam02463 |
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ... |
688-1556 |
4.19e-03 |
|
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.
Pssm-ID: 426784 [Multi-domain] Cd Length: 1161 Bit Score: 41.88 E-value: 4.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 688 EIEKRERQRKLKEKIREERRNKLAAEMGEDGEKEFQEEEEEEEEEEEEEPLPEIFipstpspilcGFYSEPGKFWVSLFG 767
Cdd:pfam02463 178 LIEETENLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLDYL----------KLNEERIDLLQELLR 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 768 IETEPIPEDIEDPKAYSIENARRKREHDKLMKEVEEIKAQKREQIKALRTEFCKLLemNEELPTHMQFKRTDFDVDSKIR 847
Cdd:pfam02463 248 DEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELL--KLERRKVDDEEKLKESEKEKKK 325
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 848 AEMHrrtafKIQQVEKELAWEKEKHELGLKKLKNRFRDPLESDTIVVHAILSDHKISSYRLVQPSKYSKFKRTSQSERKP 927
Cdd:pfam02463 326 AEKE-----LKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELK 400
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 928 SKLDRFEKEGTGRKDSQRDAGGSIAIQEESIIEKGKKFRPKTLSEIMVENQIEKTRKLILKAERAQLKIQQRKKEWEELY 1007
Cdd:pfam02463 401 SEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLV 480
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 1008 KSKpgddYEDPKDLQAIKEAQVYMGDFNLKtapdykiPEHMRINAAKKEEELGHLDSLVHGNKRYMNKCILSLRDLKVAV 1087
Cdd:pfam02463 481 KLQ----EQLELLLSRQKLEERSQKESKAR-------SGLKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKVAISTAV 549
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 1088 VEEIQCLVQELKNIQSTLHVSKHIPIPQIPQIHP---EEVPEKRFQ---YDEETLLNFKQQHMKSDDEKSPGVEQTGSGG 1161
Cdd:pfam02463 550 IVEVSATADEVEERQKLVRALTELPLGARKLRLLipkLKLPLKSIAvleIDPILNLAQLDKATLEADEDDKRAKVVEGIL 629
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 1162 PGGGFLKLSSGKDGDLTTRDSMSRSSKASTLSLDIPKYMEFEKAEPTDVELEIMKRDEIKHVYMQQYLVNRVKELIVTFD 1241
Cdd:pfam02463 630 KDTELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREK 709
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 1242 AELRLLRHQKLKLDTQMKLSDLHHVTLFQEILLLKNFEKQENILQERVNSLDKEEQYMQWKINETLKEMEEKKNEITKLQ 1321
Cdd:pfam02463 710 EELKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVE 789
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 1322 EQEKALyagfqtaigENNKFANFLMKVLKKKIKRVKKKEVEGDADEDEESEESSEEESSLESDEDESESEDEVFDDSICP 1401
Cdd:pfam02463 790 EEKEEK---------LKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELERLE 860
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 1402 TNCDVALFELTLQLREKRLDIEEALVEEKKVVDNLKKEYDTLSKKVKIVATNLNAAEEALEAYQREKQQRLNELLVviPL 1481
Cdd:pfam02463 861 EEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEILLKYEEE--PE 938
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966925061 1482 KLHQIEYVVFGEIPSDLSGTLVFSNHALRRLQEriRELQEENSKQQKLNKEWRERRKQLIREKREMTKTIHKMEE 1556
Cdd:pfam02463 939 ELLLEEADEKEKEENNKEEEEERNKRLLLAKEE--LGKVNLMAIEEFEEKEERYNKDELEKERLEEEKKKLIRAI 1011
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
1509-1693 |
5.16e-03 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 41.68 E-value: 5.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 1509 LRRLQERIRELQEENSKQQKLNKEWRERRKQLIREKREMTKTIHKMEETVRQLmiskfgrvvnLEALQTLSVNTTLEELK 1588
Cdd:COG4717 48 LERLEKEADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAELQEELEEL----------EEELEELEAELEELREE 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 1589 IRKLRKELANAKEMKMWEEKIAQMRwELMMKTKEHTRKLYQMNDLCIEKKKLDSRLNTLQNQQGNAFQSLREADVVAREE 1668
Cdd:COG4717 118 LEKLEKLLQLLPLYQELEALEAELA-ELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQD 196
|
170 180
....*....|....*....|....*
gi 966925061 1669 VTELIQLQAERISALKEEIALLRRK 1693
Cdd:COG4717 197 LAEELEELQQRLAELEEELEEAQEE 221
|
|
| 235kDa-fam |
TIGR01612 |
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ... |
1427-1649 |
6.11e-03 |
|
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.
Pssm-ID: 130673 [Multi-domain] Cd Length: 2757 Bit Score: 41.58 E-value: 6.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 1427 VEEKKVVDNLKKEYDTLSKKVKivatnlNAAEEALEAYQREKQQRLNELL-VVIPLKLHqieyvVFGEIPSDLSGTLV-- 1503
Cdd:TIGR01612 692 TEDKAKLDDLKSKIDKEYDKIQ------NMETATVELHLSNIENKKNELLdIIVEIKKH-----IHGEINKDLNKILEdf 760
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 1504 -------------FSNH--ALRRLQERIRELQEENSKQQKLNKEWRERRKQLIREKREMTKTIH-KMEETVRQL------ 1561
Cdd:TIGR01612 761 knkekelsnkindYAKEkdELNKYKSKISEIKNHYNDQINIDNIKDEDAKQNYDKSKEYIKTISiKEDEIFKIInemkfm 840
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 1562 ---MISKFGRVVNLEALQTLSVNTTLEELK--IRKLRKELANAKeMKMWEEKIAQMRwELMMKTKEHTRKLYQ-MNDLci 1635
Cdd:TIGR01612 841 kddFLNKVDKFINFENNCKEKIDSEHEQFAelTNKIKAEISDDK-LNDYEKKFNDSK-SLINEINKSIEEEYQnINTL-- 916
|
250
....*....|....
gi 966925061 1636 ekKKLDSRLNTLQN 1649
Cdd:TIGR01612 917 --KKVDEYIKICEN 928
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
1428-1697 |
7.83e-03 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 41.05 E-value: 7.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 1428 EEKKV---VDNLKKEYDTLskkvkivatnlNAAEEALEayqREKQQRlnELLVVIPlKLHQ------IEYVVFGEIPSDL 1498
Cdd:COG4913 219 EEPDTfeaADALVEHFDDL-----------ERAHEALE---DAREQI--ELLEPIR-ELAEryaaarERLAELEYLRAAL 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 1499 sgTLVFSNHALRRLQERIRELQEENSKQQKLNKEWRERRKQLIREKREMTktihkmeetvRQLMISKFGRVVNLEAlqtl 1578
Cdd:COG4913 282 --RLWFAQRRLELLEAELEELRAELARLEAELERLEARLDALREELDELE----------AQIRGNGGDRLEQLER---- 345
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 1579 svnttleelKIRKLRKELAN-AKEMKMWEEKIAQMRWELmmktkEHTRKLYQMNdlcieKKKLDSRLNTLQNQQGNAFQS 1657
Cdd:COG4913 346 ---------EIERLERELEErERRRARLEALLAALGLPL-----PASAEEFAAL-----RAEAAALLEALEEELEALEEA 406
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 966925061 1658 LREADVvareevtELIQLQAERiSALKEEIALLRRKGGLI 1697
Cdd:COG4913 407 LAEAEA-------ALRDLRREL-RELEAEIASLERRKSNI 438
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
463-498 |
8.09e-03 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 35.78 E-value: 8.09e-03
10 20 30
....*....|....*....|....*....|....*...
gi 966925061 463 ECLFSF--HSGAVEAVAVSPLTYLMATTALDCSVRIYD 498
Cdd:pfam00400 2 KLLKTLegHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
778-1090 |
8.36e-03 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 41.28 E-value: 8.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 778 EDPKAYSIENARRKREHDKLMKEVEEIKAQkrEQIKALRTEFCKLLEMNEELPTHMQFKRTDFDVDSKIRAEMHRRTAFK 857
Cdd:PTZ00121 1508 AKKKADEAKKAEEAKKADEAKKAEEAKKAD--EAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEE 1585
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 858 IQQVEKELAWEKEKHELGLKKLKNRFRDPLESDTIVVHAILSDHKISSYRLVQPSKYSKFKRTSQSERKPSKLDRFEKEG 937
Cdd:PTZ00121 1586 AKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAE 1665
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966925061 938 TGRKDSQRDAGGSIAIQEESiiEKGKKfrpktlseimvENQIEKTRKLILKAERAQLKIQQRKKEWEELYKSkpgDDYED 1017
Cdd:PTZ00121 1666 EAKKAEEDKKKAEEAKKAEE--DEKKA-----------AEALKKEAEEAKKAEELKKKEAEEKKKAEELKKA---EEENK 1729
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966925061 1018 PKDLQAIKEAQvymgdfnlktaPDYKIPEHMRINAAKKEEelghldslVHGNKRYMNKCILSLRDLKVAVVEE 1090
Cdd:PTZ00121 1730 IKAEEAKKEAE-----------EDKKKAEEAKKDEEEKKK--------IAHLKKEEEKKAEEIRKEKEAVIEE 1783
|
|
| |
