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Conserved domains on  [gi|1622968999|ref|XP_014983557|]
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WD repeat-containing protein 44 isoform X1 [Macaca mulatta]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
205-525 1.16e-36

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 141.59  E-value: 1.16e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622968999 205 YDFDQIKVVQDLSGeHMGAVWTMKFSHCGRLLASAGQDNVVRIWalknafdyfnnmrmkyntegrvspspsqeslsssks 284
Cdd:COG2319   147 WDLATGKLLRTLTG-HSGAVTSVAFSPDGKLLASGSDDGTVRLW------------------------------------ 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622968999 285 DTDTGVCSGTdedpddknapfrqrpfckYKGHTADLLDLSWSKN-YFLLSSSMDKTVRLWHISRRECLCCFQ-HIDFVTA 362
Cdd:COG2319   190 DLATGKLLRT------------------LTGHTGAVRSVAFSPDgKLLASGSADGTVRLWDLATGKLLRTLTgHSGSVRS 251

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622968999 363 IAFHPrDDRYFLSGSLDGKLRLWNIPDKKvaLWNEVDGQTKLITAANFCQNGKYAVIGTYDGRCIFYDTEhlkyhTQIHV 442
Cdd:COG2319   252 VAFSP-DGRLLASGSADGTVRLWDLATGE--LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA-----TGKLL 323

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622968999 443 RSTRGRNkvgRKITGIEPLPGENKILVTSNDSRIRLYDLRDLSLSMKYKG---YVNSssqikASFSHDFTYLVSGSEDKY 519
Cdd:COG2319   324 RTLTGHT---GAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGhtgAVTS-----VAFSPDGRTLASGSADGT 395


                  ....*.
gi 1622968999 520 VYIWST 525
Cdd:COG2319   396 VRLWDL 401
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
205-525 1.16e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 141.59  E-value: 1.16e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622968999 205 YDFDQIKVVQDLSGeHMGAVWTMKFSHCGRLLASAGQDNVVRIWalknafdyfnnmrmkyntegrvspspsqeslsssks 284
Cdd:COG2319   147 WDLATGKLLRTLTG-HSGAVTSVAFSPDGKLLASGSDDGTVRLW------------------------------------ 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622968999 285 DTDTGVCSGTdedpddknapfrqrpfckYKGHTADLLDLSWSKN-YFLLSSSMDKTVRLWHISRRECLCCFQ-HIDFVTA 362
Cdd:COG2319   190 DLATGKLLRT------------------LTGHTGAVRSVAFSPDgKLLASGSADGTVRLWDLATGKLLRTLTgHSGSVRS 251

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622968999 363 IAFHPrDDRYFLSGSLDGKLRLWNIPDKKvaLWNEVDGQTKLITAANFCQNGKYAVIGTYDGRCIFYDTEhlkyhTQIHV 442
Cdd:COG2319   252 VAFSP-DGRLLASGSADGTVRLWDLATGE--LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA-----TGKLL 323

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622968999 443 RSTRGRNkvgRKITGIEPLPGENKILVTSNDSRIRLYDLRDLSLSMKYKG---YVNSssqikASFSHDFTYLVSGSEDKY 519
Cdd:COG2319   324 RTLTGHT---GAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGhtgAVTS-----VAFSPDGRTLASGSADGT 395


                  ....*.
gi 1622968999 520 VYIWST 525
Cdd:COG2319   396 VRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 220-567 6.52e-36

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 136.31  E-value: 6.52e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622968999 220 HMGAVWTMKFSHCGRLLASAGQDNVVRIWalknafdyfnnmrmkyntegrvspspsqeslsssksDTDTGVCSGTdedpd 299
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIKVW------------------------------------DLETGELLRT----- 46

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622968999 300 dknapfrqrpfckYKGHTADLLDLSWSKN-YFLLSSSMDKTVRLWHISRRECLCCF-QHIDFVTAIAFHPrDDRYFLSGS 377
Cdd:cd00200    47 -------------LKGHTGPVRDVAASADgTYLASGSSDKTIRLWDLETGECVRTLtGHTSYVSSVAFSP-DGRILSSSS 112

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622968999 378 LDGKLRLWNIPDKKVALwnEVDGQTKLITAANFCQNGKYAVIGTYDGRCIFYDTEhlkyhTQIHVRSTRGRNKVgrkITG 457
Cdd:cd00200   113 RDKTIKVWDVETGKCLT--TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLR-----TGKCVATLTGHTGE---VNS 182

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622968999 458 IEPLPGENKILVTSNDSRIRLYDLRDLSLSMKYKG---YVNSssqikASFSHDFTYLVSGSEDKYVYIWstyhDLSKFTS 534
Cdd:cd00200   183 VAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhenGVNS-----VAFSPDGYLLASGSEDGTIRVW----DLRTGEC 253

                         330       340       350
                  ....*....|....*....|....*....|...
gi 1622968999 535 VRRdrndfwegIKAHNAVVTSAIFAPNPSLMLS 567
Cdd:cd00200   254 VQT--------LSGHTNSVTSLAWSPDGKRLAS 278
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 348-386 3.31e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 3.31e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1622968999  348 RECLCCFQ-HIDFVTAIAFHPrDDRYFLSGSLDGKLRLWN 386
Cdd:smart00320   2 GELLKTLKgHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 333-527 9.18e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 48.93  E-value: 9.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622968999 333 SSSMDKTVRLWHISRRECLCCF-QHIDFVTAIAFHPRDDRYFLSGSLDGKLRLWNIpDKKVALwnevdGQTKliTAANFC 411
Cdd:PLN00181  550 SSNFEGVVQVWDVARSQLVTEMkEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSI-NQGVSI-----GTIK--TKANIC 621

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622968999 412 ------QNGKYAVIGTYDGRCIFYDTEHLKyhtqIHVRSTRGRNKVGRKITGIEplpgENKILVTSNDSRIRLYDLrDLS 485
Cdd:PLN00181  622 cvqfpsESGRSLAFGSADHKVYYYDLRNPK----LPLCTMIGHSKTVSYVRFVD----SSTLVSSSTDNTLKLWDL-SMS 692

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1622968999 486 LS-------MKYKGYVNSSSQIKASFSHDftYLVSGSEDKYVYIwstYH 527
Cdd:PLN00181  693 ISginetplHSFMGHTNVKNFVGLSVSDG--YIATGSETNEVFV---YH 736
WD40 pfam00400
WD domain, G-beta repeat;
348-386 1.55e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 1.55e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1622968999 348 RECLCCFQ-HIDFVTAIAFHPrDDRYFLSGSLDGKLRLWN 386
Cdd:pfam00400   1 GKLLKTLEgHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
205-525 1.16e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 141.59  E-value: 1.16e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622968999 205 YDFDQIKVVQDLSGeHMGAVWTMKFSHCGRLLASAGQDNVVRIWalknafdyfnnmrmkyntegrvspspsqeslsssks 284
Cdd:COG2319   147 WDLATGKLLRTLTG-HSGAVTSVAFSPDGKLLASGSDDGTVRLW------------------------------------ 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622968999 285 DTDTGVCSGTdedpddknapfrqrpfckYKGHTADLLDLSWSKN-YFLLSSSMDKTVRLWHISRRECLCCFQ-HIDFVTA 362
Cdd:COG2319   190 DLATGKLLRT------------------LTGHTGAVRSVAFSPDgKLLASGSADGTVRLWDLATGKLLRTLTgHSGSVRS 251

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622968999 363 IAFHPrDDRYFLSGSLDGKLRLWNIPDKKvaLWNEVDGQTKLITAANFCQNGKYAVIGTYDGRCIFYDTEhlkyhTQIHV 442
Cdd:COG2319   252 VAFSP-DGRLLASGSADGTVRLWDLATGE--LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA-----TGKLL 323

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622968999 443 RSTRGRNkvgRKITGIEPLPGENKILVTSNDSRIRLYDLRDLSLSMKYKG---YVNSssqikASFSHDFTYLVSGSEDKY 519
Cdd:COG2319   324 RTLTGHT---GAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGhtgAVTS-----VAFSPDGRTLASGSADGT 395


                  ....*.
gi 1622968999 520 VYIWST 525
Cdd:COG2319   396 VRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
205-567 2.21e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 140.82  E-value: 2.21e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622968999 205 YDFDQIKVVQDLSGeHMGAVWTMKFSHCGRLLASAGQDNVVRIWalknafdyfnnmrmkyntegrvspspsqeslsssks 284
Cdd:COG2319   105 WDLATGLLLRTLTG-HTGAVRSVAFSPDGKTLASGSADGTVRLW------------------------------------ 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622968999 285 DTDTGVCSGTdedpddknapfrqrpfckYKGHTADLLDLSWSKN-YFLLSSSMDKTVRLWHISRRECLCCFQ-HIDFVTA 362
Cdd:COG2319   148 DLATGKLLRT------------------LTGHSGAVTSVAFSPDgKLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRS 209

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622968999 363 IAFHPrDDRYFLSGSLDGKLRLWNIPDKKVALwnEVDGQTKLITAANFCQNGKYAVIGTYDGRCIFYDTEhlkyhTQIHV 442
Cdd:COG2319   210 VAFSP-DGKLLASGSADGTVRLWDLATGKLLR--TLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA-----TGELL 281

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622968999 443 RSTRGRNkvgRKITGIEPLPGENKILVTSNDSRIRLYDLRDLSLSMKYKGYVNSSSQIkaSFSHDFTYLVSGSEDKYVYI 522
Cdd:COG2319   282 RTLTGHS---GGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFSPDGKTLASGSDDGTVRL 356

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 1622968999 523 WstyhDLSKFTSVRRdrndfwegIKAHNAVVTSAIFAPNPSLMLS 567
Cdd:COG2319   357 W----DLATGELLRT--------LTGHTGAVTSVAFSPDGRTLAS 389
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 220-567 6.52e-36

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 136.31  E-value: 6.52e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622968999 220 HMGAVWTMKFSHCGRLLASAGQDNVVRIWalknafdyfnnmrmkyntegrvspspsqeslsssksDTDTGVCSGTdedpd 299
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIKVW------------------------------------DLETGELLRT----- 46

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622968999 300 dknapfrqrpfckYKGHTADLLDLSWSKN-YFLLSSSMDKTVRLWHISRRECLCCF-QHIDFVTAIAFHPrDDRYFLSGS 377
Cdd:cd00200    47 -------------LKGHTGPVRDVAASADgTYLASGSSDKTIRLWDLETGECVRTLtGHTSYVSSVAFSP-DGRILSSSS 112

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622968999 378 LDGKLRLWNIPDKKVALwnEVDGQTKLITAANFCQNGKYAVIGTYDGRCIFYDTEhlkyhTQIHVRSTRGRNKVgrkITG 457
Cdd:cd00200   113 RDKTIKVWDVETGKCLT--TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLR-----TGKCVATLTGHTGE---VNS 182

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622968999 458 IEPLPGENKILVTSNDSRIRLYDLRDLSLSMKYKG---YVNSssqikASFSHDFTYLVSGSEDKYVYIWstyhDLSKFTS 534
Cdd:cd00200   183 VAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhenGVNS-----VAFSPDGYLLASGSEDGTIRVW----DLRTGEC 253

                         330       340       350
                  ....*....|....*....|....*....|...
gi 1622968999 535 VRRdrndfwegIKAHNAVVTSAIFAPNPSLMLS 567
Cdd:cd00200   254 VQT--------LSGHTNSVTSLAWSPDGKRLAS 278
WD40 COG2319
WD40 repeat [General function prediction only];
220-567 1.14e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 127.33  E-value: 1.14e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622968999 220 HMGAVWTMKFSHCGRLLASAGQDNVVRIWalknafdyfnnmrmkyntegrvspspsqeslsssksDTDTGVCSGTdedpd 299
Cdd:COG2319    77 HTAAVLSVAFSPDGRLLASASADGTVRLW------------------------------------DLATGLLLRT----- 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622968999 300 dknapfrqrpfckYKGHTADLLDLSWSKN-YFLLSSSMDKTVRLWHISRRECLCCFQ-HIDFVTAIAFHPrDDRYFLSGS 377
Cdd:COG2319   116 -------------LTGHTGAVRSVAFSPDgKTLASGSADGTVRLWDLATGKLLRTLTgHSGAVTSVAFSP-DGKLLASGS 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622968999 378 LDGKLRLWNIPDKKvaLWNEVDGQTKLITAANFCQNGKYAVIGTYDGRCIFYDTEhlkyhTQIHVRSTRGRnkvGRKITG 457
Cdd:COG2319   182 DDGTVRLWDLATGK--LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLA-----TGKLLRTLTGH---SGSVRS 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622968999 458 IEPLPGENKILVTSNDSRIRLYDLRDLSLSMKYKGYVNSSSQIkaSFSHDFTYLVSGSEDKYVYIWstyhDLSKFTSVRr 537
Cdd:COG2319   252 VAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSV--AFSPDGKLLASGSDDGTVRLW----DLATGKLLR- 324

                         330       340       350
                  ....*....|....*....|....*....|
gi 1622968999 538 drndfweGIKAHNAVVTSAIFAPNPSLMLS 567
Cdd:COG2319   325 -------TLTGHTGAVRSVAFSPDGKTLAS 347
WD40 COG2319
WD40 repeat [General function prediction only];
205-483 9.13e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 121.56  E-value: 9.13e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622968999 205 YDFDQIKVVQDLSGeHMGAVWTMKFSHCGRLLASAGQDNVVRIWalknafdyfnnmrmkyntegrvspspsqeslsssks 284
Cdd:COG2319   189 WDLATGKLLRTLTG-HTGAVRSVAFSPDGKLLASGSADGTVRLW------------------------------------ 231

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622968999 285 DTDTGVCSGTdedpddknapfrqrpfckYKGHTADLLDLSWSKN-YFLLSSSMDKTVRLWHISRRECLCCFQ-HIDFVTA 362
Cdd:COG2319   232 DLATGKLLRT------------------LTGHSGSVRSVAFSPDgRLLASGSADGTVRLWDLATGELLRTLTgHSGGVNS 293

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622968999 363 IAFHPrDDRYFLSGSLDGKLRLWNIPDKKVAlwNEVDGQTKLITAANFCQNGKYAVIGTYDGRCIFYDTEhlkyhTQIHV 442
Cdd:COG2319   294 VAFSP-DGKLLASGSDDGTVRLWDLATGKLL--RTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA-----TGELL 365

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1622968999 443 RSTRGRnkvGRKITGIEPLPGENKILVTSNDSRIRLYDLRD 483
Cdd:COG2319   366 RTLTGH---TGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
315-567 6.35e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.16  E-value: 6.35e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622968999 315 GHTADLLDLSWSKNY-FLLSSSMDKTVRLWHISRRECLCCFQ-HIDFVTAIAFHPrDDRYFLSGSLDGKLRLWNIPDKKv 392
Cdd:COG2319    76 GHTAAVLSVAFSPDGrLLASASADGTVRLWDLATGLLLRTLTgHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATGK- 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622968999 393 aLWNEVDGQTKLITAANFCQNGKYAVIGTYDGRCIFYDTEHLKyhtqiHVRSTRGRNKVgrkITGIEPLPGENKILVTSN 472
Cdd:COG2319   154 -LLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK-----LLRTLTGHTGA---VRSVAFSPDGKLLASGSA 224

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622968999 473 DSRIRLYDLRDLSLSMKYKGYVNSSSQIkaSFSHDFTYLVSGSEDKYVYIWstyhDLSKFTSVRRdrndfwegIKAHNAV 552
Cdd:COG2319   225 DGTVRLWDLATGKLLRTLTGHSGSVRSV--AFSPDGRLLASGSADGTVRLW----DLATGELLRT--------LTGHSGG 290

                         250
                  ....*....|....*
gi 1622968999 553 VTSAIFAPNPSLMLS 567
Cdd:COG2319   291 VNSVAFSPDGKLLAS 305
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 313-567 9.58e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 98.56  E-value: 9.58e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622968999 313 YKGHTADLLDLSWSKNY-FLLSSSMDKTVRLWHISRRECLCCFQ-HIDFVTAIAFHPrDDRYFLSGSLDGKLRLWNIPDK 390
Cdd:cd00200     5 LKGHTGGVTCVAFSPDGkLLATGSGDGTIKVWDLETGELLRTLKgHTGPVRDVAASA-DGTYLASGSSDKTIRLWDLETG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622968999 391 KVAlwNEVDGQTKLITAANFCQNGKYAVIGTYDGRCIFYDTEHLKYhtqihVRSTRGRNkvgrkitgieplpgenkilvt 470
Cdd:cd00200    84 ECV--RTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKC-----LTTLRGHT--------------------- 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622968999 471 sndsrirlydlrdlslsmkykGYVNSssqikASFSHDFTYLVSGSEDKYVYIWstyhDLSKFTSVRRdrndfwegIKAHN 550
Cdd:cd00200   136 ---------------------DWVNS-----VAFSPDGTFVASSSQDGTIKLW----DLRTGKCVAT--------LTGHT 177

                         250
                  ....*....|....*..
gi 1622968999 551 AVVTSAIFAPNPSLMLS 567
Cdd:cd00200   178 GEVNSVAFSPDGEKLLS 194
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 397-564 2.21e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 61.97  E-value: 2.21e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622968999 397 EVDGQTKLITAANFCQNGKYAVIGTYDGRCIFYDTEHLKYHTQIHVRStrgrnkvgRKITGIEPLPGENKILVTSNDSRI 476
Cdd:cd00200     4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHT--------GPVRDVAASADGTYLASGSSDKTI 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622968999 477 RLYDLRDLSLSMKYKG---YVNSssqikASFSHDFTYLVSGSEDKYVYIWstyhDLSKFTSVRRdrndfwegIKAHNAVV 553
Cdd:cd00200    76 RLWDLETGECVRTLTGhtsYVSS-----VAFSPDGRILSSSSRDKTIKVW----DVETGKCLTT--------LRGHTDWV 138

                         170
                  ....*....|.
gi 1622968999 554 TSAIFAPNPSL 564
Cdd:cd00200   139 NSVAFSPDGTF 149
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 348-386 3.31e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 3.31e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1622968999  348 RECLCCFQ-HIDFVTAIAFHPrDDRYFLSGSLDGKLRLWN 386
Cdd:smart00320   2 GELLKTLKgHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 211-248 5.91e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 5.91e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1622968999  211 KVVQDLSGeHMGAVWTMKFSHCGRLLASAGQDNVVRIW 248
Cdd:smart00320   3 ELLKTLKG-HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 333-527 9.18e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 48.93  E-value: 9.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622968999 333 SSSMDKTVRLWHISRRECLCCF-QHIDFVTAIAFHPRDDRYFLSGSLDGKLRLWNIpDKKVALwnevdGQTKliTAANFC 411
Cdd:PLN00181  550 SSNFEGVVQVWDVARSQLVTEMkEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSI-NQGVSI-----GTIK--TKANIC 621

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622968999 412 ------QNGKYAVIGTYDGRCIFYDTEHLKyhtqIHVRSTRGRNKVGRKITGIEplpgENKILVTSNDSRIRLYDLrDLS 485
Cdd:PLN00181  622 cvqfpsESGRSLAFGSADHKVYYYDLRNPK----LPLCTMIGHSKTVSYVRFVD----SSTLVSSSTDNTLKLWDL-SMS 692

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1622968999 486 LS-------MKYKGYVNSSSQIKASFSHDftYLVSGSEDKYVYIwstYH 527
Cdd:PLN00181  693 ISginetplHSFMGHTNVKNFVGLSVSDG--YIATGSETNEVFV---YH 736
PTZ00420 PTZ00420
coronin; Provisional
 306-394 1.27e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 48.41  E-value: 1.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622968999 306 RQRPFCKYKGHTADLLDLSWSKNY--FLLSSSMDKTVRLWHISR--------RECLCCFQ-HIDFVTAIAFHPRDDRYFL 374
Cdd:PTZ00420   63 RKPPVIKLKGHTSSILDLQFNPCFseILASGSEDLTIRVWEIPHndesvkeiKDPQCILKgHKKKISIIDWNPMNYYIMC 142

                          90       100
                  ....*....|....*....|
gi 1622968999 375 SGSLDGKLRLWNIPDKKVAL 394
Cdd:PTZ00420  143 SSGFDSFVNIWDIENEKRAF 162
WD40 pfam00400
WD domain, G-beta repeat;
348-386 1.55e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 1.55e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1622968999 348 RECLCCFQ-HIDFVTAIAFHPrDDRYFLSGSLDGKLRLWN 386
Cdd:pfam00400   1 GKLLKTLEgHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 308-344 7.90e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 7.90e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1622968999  308 RPFCKYKGHTADLLDLSWSKN-YFLLSSSMDKTVRLWH 344
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDgKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
211-248 9.20e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 9.20e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1622968999 211 KVVQDLSGeHMGAVWTMKFSHCGRLLASAGQDNVVRIW 248
Cdd:pfam00400   2 KLLKTLEG-HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
312-343 2.27e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 2.27e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1622968999 312 KYKGHTADLLDLSWSKN-YFLLSSSMDKTVRLW 343
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDgKLLASGSDDGTVKVW 38
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 369-525 3.66e-03

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 39.90  E-value: 3.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622968999 369 DDRYFLSGsldGK---LRLWNIPDKKVALW-------NEVDGQTKL-ITAANFcqngkyavIGTYDGRCIFYDTEHlkyH 437
Cdd:cd22857   137 NENYFAFG---GKeveLNVWDLEEKPGKIWraknvpnDSLGLRVPVwVTDLTF--------LSKDDHRKIVTGTGY---H 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622968999 438 tQIHVRSTR-GR----NKVGRK--ITGIEPLPGENKILVTSNDSRIRLYDLRDLSLSMKYKGYvnSSSQIKASFSH-DFT 509
Cdd:cd22857   203 -QVRLYDTRaQRrpvvSVDFGEtpIKAVAEDPDGHTVYVGDTSGDLASIDLRTGKLLGCFKGK--CGGSIRSIARHpELP 279

                         170
                  ....*....|....*.
gi 1622968999 510 YLVSGSEDKYVYIWST 525
Cdd:cd22857   280 LIASCGLDRYLRIWDT 295
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 491-524 8.65e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.60  E-value: 8.65e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1622968999  491 KGYVNSssqikASFSHDFTYLVSGSEDKYVYIWS 524
Cdd:smart00320  12 TGPVTS-----VAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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