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Conserved domains on  [gi|967506250|ref|XP_014983258|]
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protocadherin-11 X-linked isoform X5 [Macaca mulatta]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Protocadherin pfam08374
Protocadherin; The structure of protocadherins is similar to that of classic cadherins ...
 775-976 1.24e-80

Protocadherin; The structure of protocadherins is similar to that of classic cadherins (pfam00028), but particularly on the cytoplasmic domains they also have some unique features. They are expressed in a variety of organizms and are found in high concentrations in the brain where they seem to be localized mainly at cell-cell contact sites. Their expression seems to be developmentally regulated.


:

Pssm-ID: 462451  Cd Length: 217  Bit Score: 263.91  E-value: 1.24e-80
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967506250   775 SVTNATLINELLHKSTEAPVTPNT-EIADASSPTIDYVKILVAVVAGTITVVVVISITAVVR-CRQA--PHLKAAQKnkQ 850
Cdd:pfam08374    1 SLANATLVEELVRRSLETPLDRDIaGDPDYSSLGKDYLKILIAILAGAMTVILVIFIVVLVRyCRQKekPGYKAGKK--Q 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967506250   851 NSEWATPNPENRQMIMMKKKKKKKKHP---PKNLLLNFVTIEETKADDVDDDGNSITLELPIdleeqtmgkynwvTTPTT 927
Cdd:pfam08374   79 NSDWVTPNPENKQMKGKKKKKKKRPKPaklPKSLLLNLVTIEESKPDDVENEGDSPRIDLPI-------------TLPTT 145

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 967506250   928 FKPDSPDLARHYKSASPQPAFQIQPETPLN-SKHHIIQELPLDNTFV-ACD 976
Cdd:pfam08374  146 FKPDSPDLARHYKSNSPLPAFQLQPESPSAsKKHQAVQELPLDNTFVgTGD 196
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 253-351 9.19e-34

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 125.50  E-value: 9.19e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967506250  253 EIEVSIPENAPVGTSVTQLHATDADIGENARIHFSfsnLVSNIAKRLFHLNSTTGLITIKEPLDREETPNHKLLVLASDG 332
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYS---IVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                          90       100
                  ....*....|....*....|.
gi 967506250  333 GLVP--ARAMVLVNVTDVNDN 351
Cdd:cd11304    78 GGPPlsSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 574-669 4.61e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 123.19  E-value: 4.61e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967506250  574 EYNFYVPENLPKHGTVGLITVTDPDYGENSAVTLSILDENDG--FTIDSKTGVIRPNISFDREKQESYTFYVKAEDGGRV 651
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDglFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 967506250  652 SRSSSAKVTINVVDVNDN 669
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 472-566 3.24e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 120.88  E-value: 3.24e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967506250  472 TVSIPENNSPGIQLTKVSATDADTGPNAEINF-LLGPDAPPEFSLDRRTGMLTVLKKLDREKEEKYFFTVLAKDNGVPPL 550
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYsIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                          90
                  ....*....|....*.
gi 967506250  551 TSNVTVFVSVIDQNDN 566
Cdd:cd11304    83 SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 143-245 9.10e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.22  E-value: 9.10e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967506250  143 VINISIPENSAINSKYTLPAAIDPDVGINGVQNYELIKG--QNIFgldVIETPEGEkmpqLIVQKELDREEKDTYVMKVK 220
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGneDGLF---SIDPSTGE----ITTAKPLDREEQSSYTLTVT 73

                          90       100
                  ....*....|....*....|....*
gi 967506250  221 VEDGGFPQRSSTAILQVSVTDTNDN 245
Cdd:cd11304    74 ATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 681-772 6.57e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.83  E-value: 6.57e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967506250  681 SYELVLP-STDPGTVVFQVIAVDNDTGMNAEVRYSIVGENTRDLFEINETTGNIIMKEKCDVTDLGLHRVLVKANDLGQP 759
Cdd:cd11304     1 SYEVSVPeNAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|...
gi 967506250  760 dSLFSVVTVNLFV 772
Cdd:cd11304    81 -PLSSTATVTITV 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 384-464 1.97e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 63.91  E-value: 1.97e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967506250    384 TVTDKDADHNGRVTCF---TDHEIPFRLRPvfsNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDEN 460
Cdd:smart00112    1 SATDADSGENGKVTYSilsGNDDGLFSIDP---ETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 967506250    461 DNAP 464
Cdd:smart00112   78 DNAP 81
KLF10_11_N super family cl41731
N-terminal domain of Kruppel-like factor (KLF) 10, KLF11, and similar proteins; This subfamily ...
 1171-1280 3.00e-06

N-terminal domain of Kruppel-like factor (KLF) 10, KLF11, and similar proteins; This subfamily is composed of Kruppel-like factor or Krueppel-like factor (KLF) 10, KLF11, and similar proteins. KLF10 was first identified in human osteoblasts and plays a role in mediating estrogen (E2) signaling in bone and skeletal homeostasis and a regulatory role in tumor formation and metastasis. KLF11 is involved in cell growth, apoptosis, cellular inflammation and differentiation, endometriosis, and cholesterol, prostaglandin, neurotransmitter, fat, and sugar metabolism. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF10/11 belong to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF10, KLF11, and similar proteins.


The actual alignment was detected with superfamily member cd21974:

Pssm-ID: 425362 [Multi-domain]  Cd Length: 229  Bit Score: 49.93  E-value: 3.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967506250 1171 LCQSPPlsqasthhHSPPVTQTIALCHSPPVTQTIALCHSPPPIQISALHHSPPL--AQATA-LRH---SPPSAQASALC 1244
Cdd:cd21974    56 LCMTPP--------YSPPFFEASHSPSVASLHPPSAASSQPPPEPESSEPPAASPqrAQATSvIRHtadPVPVSPPPVLC 127

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 967506250 1245 YSPPLAQAAAICHGSPLPQVTALHRSQAQSSVSLQQ 1280
Cdd:cd21974   128 QMLPVSSSSGVIVAFLKAPQQPSPQPQKPALPQPQV 163
Cadherin_2 super family cl29227
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 28-97 6.11e-06

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


The actual alignment was detected with superfamily member pfam08266:

Pssm-ID: 462413  Cd Length: 83  Bit Score: 45.60  E-value: 6.11e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967506250    28 YTIREEMPENVLIGDLLKDLNLSLvsnKSLsSAMQFKLVYKtGDVPLIRIEEGTGEIFTTGaRIDREKLC 97
Cdd:pfam08266    4 YSVPEETERGSFVGNLAKDLGLEV---GEL-AARGARVVSK-GNKQYFQLNPETGDLLLNE-KLDREELC 67
 
Name Accession Description Interval E-value
Protocadherin pfam08374
Protocadherin; The structure of protocadherins is similar to that of classic cadherins ...
 775-976 1.24e-80

Protocadherin; The structure of protocadherins is similar to that of classic cadherins (pfam00028), but particularly on the cytoplasmic domains they also have some unique features. They are expressed in a variety of organizms and are found in high concentrations in the brain where they seem to be localized mainly at cell-cell contact sites. Their expression seems to be developmentally regulated.


Pssm-ID: 462451  Cd Length: 217  Bit Score: 263.91  E-value: 1.24e-80
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967506250   775 SVTNATLINELLHKSTEAPVTPNT-EIADASSPTIDYVKILVAVVAGTITVVVVISITAVVR-CRQA--PHLKAAQKnkQ 850
Cdd:pfam08374    1 SLANATLVEELVRRSLETPLDRDIaGDPDYSSLGKDYLKILIAILAGAMTVILVIFIVVLVRyCRQKekPGYKAGKK--Q 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967506250   851 NSEWATPNPENRQMIMMKKKKKKKKHP---PKNLLLNFVTIEETKADDVDDDGNSITLELPIdleeqtmgkynwvTTPTT 927
Cdd:pfam08374   79 NSDWVTPNPENKQMKGKKKKKKKRPKPaklPKSLLLNLVTIEESKPDDVENEGDSPRIDLPI-------------TLPTT 145

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 967506250   928 FKPDSPDLARHYKSASPQPAFQIQPETPLN-SKHHIIQELPLDNTFV-ACD 976
Cdd:pfam08374  146 FKPDSPDLARHYKSNSPLPAFQLQPESPSAsKKHQAVQELPLDNTFVgTGD 196
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 253-351 9.19e-34

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 125.50  E-value: 9.19e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967506250  253 EIEVSIPENAPVGTSVTQLHATDADIGENARIHFSfsnLVSNIAKRLFHLNSTTGLITIKEPLDREETPNHKLLVLASDG 332
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYS---IVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                          90       100
                  ....*....|....*....|.
gi 967506250  333 GLVP--ARAMVLVNVTDVNDN 351
Cdd:cd11304    78 GGPPlsSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 574-669 4.61e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 123.19  E-value: 4.61e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967506250  574 EYNFYVPENLPKHGTVGLITVTDPDYGENSAVTLSILDENDG--FTIDSKTGVIRPNISFDREKQESYTFYVKAEDGGRV 651
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDglFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 967506250  652 SRSSSAKVTINVVDVNDN 669
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 472-566 3.24e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 120.88  E-value: 3.24e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967506250  472 TVSIPENNSPGIQLTKVSATDADTGPNAEINF-LLGPDAPPEFSLDRRTGMLTVLKKLDREKEEKYFFTVLAKDNGVPPL 550
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYsIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                          90
                  ....*....|....*.
gi 967506250  551 TSNVTVFVSVIDQNDN 566
Cdd:cd11304    83 SSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 489-568 2.00e-25

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 100.89  E-value: 2.00e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967506250    489 SATDADTGPNAEINF-LLGPDAPPEFSLDRRTGMLTVLKKLDREKEEKYFFTVLAKDNGVPPLTSNVTVFVSVIDQNDNS 567
Cdd:smart00112    1 SATDADSGENGKVTYsILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 967506250    568 P 568
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 593-671 9.90e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 96.26  E-value: 9.90e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967506250    593 TVTDPDYGENSAVTLSILDENDG--FTIDSKTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNK 670
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDglFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 967506250    671 P 671
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
254-346 1.99e-22

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 92.75  E-value: 1.99e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967506250   254 IEVSIPENAPVGTSVTQLHATDADIGENARIHFSfsnLVSNIAKRLFHLNSTTGLITIKEPLDREETPNHKLLVLASDGG 333
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYS---ILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|....*
gi 967506250   334 LVP--ARAMVLVNVT 346
Cdd:pfam00028   78 GPPlsSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 272-353 3.42e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 91.64  E-value: 3.42e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967506250    272 HATDADIGENARIHFSfsnLVSNIAKRLFHLNSTTGLITIKEPLDREETPNHKLLVLASDGGLVP--ARAMVLVNVTDVN 349
Cdd:smart00112    1 SATDADSGENGKVTYS---ILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPlsSTATVTITVLDVN 77


                    ....
gi 967506250    350 DNVP 353
Cdd:smart00112   78 DNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 143-245 9.10e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.22  E-value: 9.10e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967506250  143 VINISIPENSAINSKYTLPAAIDPDVGINGVQNYELIKG--QNIFgldVIETPEGEkmpqLIVQKELDREEKDTYVMKVK 220
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGneDGLF---SIDPSTGE----ITTAKPLDREEQSSYTLTVT 73

                          90       100
                  ....*....|....*....|....*
gi 967506250  221 VEDGGFPQRSSTAILQVSVTDTNDN 245
Cdd:cd11304    74 ATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
472-561 2.06e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 86.97  E-value: 2.06e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967506250   472 TVSIPENNSPGIQLTKVSATDADTGPNAEINF-LLGPDAPPEFSLDRRTGMLTVLKKLDREKEEKYFFTVLAKDNGVPPL 550
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYsILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPL 81

                           90
                   ....*....|.
gi 967506250   551 TSNVTVFVSVI 561
Cdd:pfam00028   82 SSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
575-663 5.84e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 85.82  E-value: 5.84e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967506250   575 YNFYVPENLPKHGTVGLITVTDPDYGENSAVTLSIL--DENDGFTIDSKTGVIRPNISFDREKQESYTFYVKAEDGGRVS 652
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILggGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 967506250   653 RSSSAKVTINV 663
Cdd:pfam00028   81 LSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 681-772 6.57e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.83  E-value: 6.57e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967506250  681 SYELVLP-STDPGTVVFQVIAVDNDTGMNAEVRYSIVGENTRDLFEINETTGNIIMKEKCDVTDLGLHRVLVKANDLGQP 759
Cdd:cd11304     1 SYEVSVPeNAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|...
gi 967506250  760 dSLFSVVTVNLFV 772
Cdd:cd11304    81 -PLSSTATVTITV 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 163-247 1.16e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 75.85  E-value: 1.16e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967506250    163 AIDPDVGINGVQNYElIKGQNIFGLDVIETPEGEkmpqLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDT 242
Cdd:smart00112    2 ATDADSGENGKVTYS-ILSGNDDGLFSIDPETGE----ITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                    ....*
gi 967506250    243 NDNHP 247
Cdd:smart00112   77 NDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 384-464 1.97e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 63.91  E-value: 1.97e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967506250    384 TVTDKDADHNGRVTCF---TDHEIPFRLRPvfsNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDEN 460
Cdd:smart00112    1 SATDADSGENGKVTYSilsGNDDGLFSIDP---ETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 967506250    461 DNAP 464
Cdd:smart00112   78 DNAP 81
Cadherin pfam00028
Cadherin domain;
691-772 4.12e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.47  E-value: 4.12e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967506250   691 PGTVVFQVIAVDNDTGMNAEVRYSIVGENTRDLFEINETTGNIIMKEKCDVTDLGLHRVLVKANDLGQPdSLFSVVTVNL 770
Cdd:pfam00028   11 VGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP-PLSSTATVTI 89


                   ..
gi 967506250   771 FV 772
Cdd:pfam00028   90 TV 91
Cadherin pfam00028
Cadherin domain;
144-240 1.15e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 62.32  E-value: 1.15e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967506250   144 INISIPENSAINSKYTLPAAIDPDVGINGVQNYeLIKGQNIFGLDVIETPEGEkmpqLIVQKELDREEKDTYVMKVKVED 223
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFY-SILGGGPGGNFRIDPDTGD----ISTTKPLDRESIGEYELTVEATD 75

                           90
                   ....*....|....*..
gi 967506250   224 GGFPQRSSTAILQVSVT 240
Cdd:pfam00028   76 SGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 700-772 3.21e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 60.44  E-value: 3.21e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 967506250    700 AVDNDTGMNAEVRYSIVGENTRDLFEINETTGNIIMKEKCDVTDLGLHRVLVKANDLGQPdSLFSVVTVNLFV 772
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP-PLSSTATVTITV 73
Cadherin pfam00028
Cadherin domain;
367-456 8.36e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 56.93  E-value: 8.36e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967506250   367 TVVLSENVPLNTKIALITVTDKDADHNGRVTcftdHEIpfrLRPVFSNQF-------LLETAAYLDYESTKEYAIKLLAA 439
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIF----YSI---LGGGPGGNFridpdtgDISTTKPLDRESIGEYELTVEAT 74

                           90
                   ....*....|....*..
gi 967506250   440 DAGKPPLNQSAMLFIKV 456
Cdd:pfam00028   75 DSGGPPLSSTATVTITV 91
KLF10_11_N cd21974
N-terminal domain of Kruppel-like factor (KLF) 10, KLF11, and similar proteins; This subfamily ...
 1171-1280 3.00e-06

N-terminal domain of Kruppel-like factor (KLF) 10, KLF11, and similar proteins; This subfamily is composed of Kruppel-like factor or Krueppel-like factor (KLF) 10, KLF11, and similar proteins. KLF10 was first identified in human osteoblasts and plays a role in mediating estrogen (E2) signaling in bone and skeletal homeostasis and a regulatory role in tumor formation and metastasis. KLF11 is involved in cell growth, apoptosis, cellular inflammation and differentiation, endometriosis, and cholesterol, prostaglandin, neurotransmitter, fat, and sugar metabolism. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF10/11 belong to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF10, KLF11, and similar proteins.


Pssm-ID: 409243 [Multi-domain]  Cd Length: 229  Bit Score: 49.93  E-value: 3.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967506250 1171 LCQSPPlsqasthhHSPPVTQTIALCHSPPVTQTIALCHSPPPIQISALHHSPPL--AQATA-LRH---SPPSAQASALC 1244
Cdd:cd21974    56 LCMTPP--------YSPPFFEASHSPSVASLHPPSAASSQPPPEPESSEPPAASPqrAQATSvIRHtadPVPVSPPPVLC 127

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 967506250 1245 YSPPLAQAAAICHGSPLPQVTALHRSQAQSSVSLQQ 1280
Cdd:cd21974   128 QMLPVSSSSGVIVAFLKAPQQPSPQPQKPALPQPQV 163
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 28-97 6.11e-06

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 45.60  E-value: 6.11e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967506250    28 YTIREEMPENVLIGDLLKDLNLSLvsnKSLsSAMQFKLVYKtGDVPLIRIEEGTGEIFTTGaRIDREKLC 97
Cdd:pfam08266    4 YSVPEETERGSFVGNLAKDLGLEV---GEL-AARGARVVSK-GNKQYFQLNPETGDLLLNE-KLDREELC 67
FAM47 pfam14642
FAM47 family; The function of this Chordate family of proteins is not known.
 1175-1242 1.14e-05

FAM47 family; The function of this Chordate family of proteins is not known.


Pssm-ID: 405345 [Multi-domain]  Cd Length: 257  Bit Score: 48.72  E-value: 1.14e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 967506250  1175 PPLSQASTHHHSPPVTQTIALCHSPPVTQTIALCHSPPPIQISALHHSPPLAQATALRHSPPSAQASA 1242
Cdd:pfam14642  190 PPETRVSCLPPEPPKTPVSSLRPEPPETGVSHLRPQPPKTQVSSLHLEPPETGVSHLRPEPPKTQVSS 257
 
Name Accession Description Interval E-value
Protocadherin pfam08374
Protocadherin; The structure of protocadherins is similar to that of classic cadherins ...
 775-976 1.24e-80

Protocadherin; The structure of protocadherins is similar to that of classic cadherins (pfam00028), but particularly on the cytoplasmic domains they also have some unique features. They are expressed in a variety of organizms and are found in high concentrations in the brain where they seem to be localized mainly at cell-cell contact sites. Their expression seems to be developmentally regulated.


Pssm-ID: 462451  Cd Length: 217  Bit Score: 263.91  E-value: 1.24e-80
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967506250   775 SVTNATLINELLHKSTEAPVTPNT-EIADASSPTIDYVKILVAVVAGTITVVVVISITAVVR-CRQA--PHLKAAQKnkQ 850
Cdd:pfam08374    1 SLANATLVEELVRRSLETPLDRDIaGDPDYSSLGKDYLKILIAILAGAMTVILVIFIVVLVRyCRQKekPGYKAGKK--Q 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967506250   851 NSEWATPNPENRQMIMMKKKKKKKKHP---PKNLLLNFVTIEETKADDVDDDGNSITLELPIdleeqtmgkynwvTTPTT 927
Cdd:pfam08374   79 NSDWVTPNPENKQMKGKKKKKKKRPKPaklPKSLLLNLVTIEESKPDDVENEGDSPRIDLPI-------------TLPTT 145

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 967506250   928 FKPDSPDLARHYKSASPQPAFQIQPETPLN-SKHHIIQELPLDNTFV-ACD 976
Cdd:pfam08374  146 FKPDSPDLARHYKSNSPLPAFQLQPESPSAsKKHQAVQELPLDNTFVgTGD 196
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 253-351 9.19e-34

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 125.50  E-value: 9.19e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967506250  253 EIEVSIPENAPVGTSVTQLHATDADIGENARIHFSfsnLVSNIAKRLFHLNSTTGLITIKEPLDREETPNHKLLVLASDG 332
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYS---IVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                          90       100
                  ....*....|....*....|.
gi 967506250  333 GLVP--ARAMVLVNVTDVNDN 351
Cdd:cd11304    78 GGPPlsSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 574-669 4.61e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 123.19  E-value: 4.61e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967506250  574 EYNFYVPENLPKHGTVGLITVTDPDYGENSAVTLSILDENDG--FTIDSKTGVIRPNISFDREKQESYTFYVKAEDGGRV 651
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDglFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 967506250  652 SRSSSAKVTINVVDVNDN 669
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 472-566 3.24e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 120.88  E-value: 3.24e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967506250  472 TVSIPENNSPGIQLTKVSATDADTGPNAEINF-LLGPDAPPEFSLDRRTGMLTVLKKLDREKEEKYFFTVLAKDNGVPPL 550
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYsIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                          90
                  ....*....|....*.
gi 967506250  551 TSNVTVFVSVIDQNDN 566
Cdd:cd11304    83 SSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 489-568 2.00e-25

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 100.89  E-value: 2.00e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967506250    489 SATDADTGPNAEINF-LLGPDAPPEFSLDRRTGMLTVLKKLDREKEEKYFFTVLAKDNGVPPLTSNVTVFVSVIDQNDNS 567
Cdd:smart00112    1 SATDADSGENGKVTYsILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 967506250    568 P 568
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 593-671 9.90e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 96.26  E-value: 9.90e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967506250    593 TVTDPDYGENSAVTLSILDENDG--FTIDSKTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNK 670
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDglFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 967506250    671 P 671
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
254-346 1.99e-22

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 92.75  E-value: 1.99e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967506250   254 IEVSIPENAPVGTSVTQLHATDADIGENARIHFSfsnLVSNIAKRLFHLNSTTGLITIKEPLDREETPNHKLLVLASDGG 333
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYS---ILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|....*
gi 967506250   334 LVP--ARAMVLVNVT 346
Cdd:pfam00028   78 GPPlsSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 272-353 3.42e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 91.64  E-value: 3.42e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967506250    272 HATDADIGENARIHFSfsnLVSNIAKRLFHLNSTTGLITIKEPLDREETPNHKLLVLASDGGLVP--ARAMVLVNVTDVN 349
Cdd:smart00112    1 SATDADSGENGKVTYS---ILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPlsSTATVTITVLDVN 77


                    ....
gi 967506250    350 DNVP 353
Cdd:smart00112   78 DNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 143-245 9.10e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.22  E-value: 9.10e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967506250  143 VINISIPENSAINSKYTLPAAIDPDVGINGVQNYELIKG--QNIFgldVIETPEGEkmpqLIVQKELDREEKDTYVMKVK 220
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGneDGLF---SIDPSTGE----ITTAKPLDREEQSSYTLTVT 73

                          90       100
                  ....*....|....*....|....*
gi 967506250  221 VEDGGFPQRSSTAILQVSVTDTNDN 245
Cdd:cd11304    74 ATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
472-561 2.06e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 86.97  E-value: 2.06e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967506250   472 TVSIPENNSPGIQLTKVSATDADTGPNAEINF-LLGPDAPPEFSLDRRTGMLTVLKKLDREKEEKYFFTVLAKDNGVPPL 550
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYsILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPL 81

                           90
                   ....*....|.
gi 967506250   551 TSNVTVFVSVI 561
Cdd:pfam00028   82 SSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
575-663 5.84e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 85.82  E-value: 5.84e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967506250   575 YNFYVPENLPKHGTVGLITVTDPDYGENSAVTLSIL--DENDGFTIDSKTGVIRPNISFDREKQESYTFYVKAEDGGRVS 652
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILggGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 967506250   653 RSSSAKVTINV 663
Cdd:pfam00028   81 LSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 681-772 6.57e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.83  E-value: 6.57e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967506250  681 SYELVLP-STDPGTVVFQVIAVDNDTGMNAEVRYSIVGENTRDLFEINETTGNIIMKEKCDVTDLGLHRVLVKANDLGQP 759
Cdd:cd11304     1 SYEVSVPeNAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|...
gi 967506250  760 dSLFSVVTVNLFV 772
Cdd:cd11304    81 -PLSSTATVTITV 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 163-247 1.16e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 75.85  E-value: 1.16e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967506250    163 AIDPDVGINGVQNYElIKGQNIFGLDVIETPEGEkmpqLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDT 242
Cdd:smart00112    2 ATDADSGENGKVTYS-ILSGNDDGLFSIDPETGE----ITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                    ....*
gi 967506250    243 NDNHP 247
Cdd:smart00112   77 NDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 384-464 1.97e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 63.91  E-value: 1.97e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967506250    384 TVTDKDADHNGRVTCF---TDHEIPFRLRPvfsNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDEN 460
Cdd:smart00112    1 SATDADSGENGKVTYSilsGNDDGLFSIDP---ETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 967506250    461 DNAP 464
Cdd:smart00112   78 DNAP 81
Cadherin pfam00028
Cadherin domain;
691-772 4.12e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.47  E-value: 4.12e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967506250   691 PGTVVFQVIAVDNDTGMNAEVRYSIVGENTRDLFEINETTGNIIMKEKCDVTDLGLHRVLVKANDLGQPdSLFSVVTVNL 770
Cdd:pfam00028   11 VGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP-PLSSTATVTI 89


                   ..
gi 967506250   771 FV 772
Cdd:pfam00028   90 TV 91
Cadherin pfam00028
Cadherin domain;
144-240 1.15e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 62.32  E-value: 1.15e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967506250   144 INISIPENSAINSKYTLPAAIDPDVGINGVQNYeLIKGQNIFGLDVIETPEGEkmpqLIVQKELDREEKDTYVMKVKVED 223
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFY-SILGGGPGGNFRIDPDTGD----ISTTKPLDRESIGEYELTVEATD 75

                           90
                   ....*....|....*..
gi 967506250   224 GGFPQRSSTAILQVSVT 240
Cdd:pfam00028   76 SGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 700-772 3.21e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 60.44  E-value: 3.21e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 967506250    700 AVDNDTGMNAEVRYSIVGENTRDLFEINETTGNIIMKEKCDVTDLGLHRVLVKANDLGQPdSLFSVVTVNLFV 772
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP-PLSSTATVTITV 73
Cadherin pfam00028
Cadherin domain;
367-456 8.36e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 56.93  E-value: 8.36e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967506250   367 TVVLSENVPLNTKIALITVTDKDADHNGRVTcftdHEIpfrLRPVFSNQF-------LLETAAYLDYESTKEYAIKLLAA 439
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIF----YSI---LGGGPGGNFridpdtgDISTTKPLDRESIGEYELTVEAT 74

                           90
                   ....*....|....*..
gi 967506250   440 DAGKPPLNQSAMLFIKV 456
Cdd:pfam00028   75 DSGGPPLSSTATVTITV 91
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 470-566 2.80e-06

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 46.95  E-value: 2.80e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967506250  470 LVTVSIPENNSPGIQLTKV-SATDADTGPNAEINfLLGPDAPPE-FSLDRRTGMLTVLKKLDREKEEKYFFTVLAKDNGV 547
Cdd:cd00031     1 IPDGSAVEGRSRGSFRVSIpTDLIASSGEIIKIS-AAGKEALPSwLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGA 79

                          90
                  ....*....|....*....
gi 967506250  548 PPLTSNVTVFVSVIDQNDN 566
Cdd:cd00031    80 NVPQTSSVFSIEVYDENDN 98
KLF10_11_N cd21974
N-terminal domain of Kruppel-like factor (KLF) 10, KLF11, and similar proteins; This subfamily ...
 1171-1280 3.00e-06

N-terminal domain of Kruppel-like factor (KLF) 10, KLF11, and similar proteins; This subfamily is composed of Kruppel-like factor or Krueppel-like factor (KLF) 10, KLF11, and similar proteins. KLF10 was first identified in human osteoblasts and plays a role in mediating estrogen (E2) signaling in bone and skeletal homeostasis and a regulatory role in tumor formation and metastasis. KLF11 is involved in cell growth, apoptosis, cellular inflammation and differentiation, endometriosis, and cholesterol, prostaglandin, neurotransmitter, fat, and sugar metabolism. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF10/11 belong to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF10, KLF11, and similar proteins.


Pssm-ID: 409243 [Multi-domain]  Cd Length: 229  Bit Score: 49.93  E-value: 3.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967506250 1171 LCQSPPlsqasthhHSPPVTQTIALCHSPPVTQTIALCHSPPPIQISALHHSPPL--AQATA-LRH---SPPSAQASALC 1244
Cdd:cd21974    56 LCMTPP--------YSPPFFEASHSPSVASLHPPSAASSQPPPEPESSEPPAASPqrAQATSvIRHtadPVPVSPPPVLC 127

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 967506250 1245 YSPPLAQAAAICHGSPLPQVTALHRSQAQSSVSLQQ 1280
Cdd:cd21974   128 QMLPVSSSSGVIVAFLKAPQQPSPQPQKPALPQPQV 163
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 28-97 6.11e-06

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 45.60  E-value: 6.11e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967506250    28 YTIREEMPENVLIGDLLKDLNLSLvsnKSLsSAMQFKLVYKtGDVPLIRIEEGTGEIFTTGaRIDREKLC 97
Cdd:pfam08266    4 YSVPEETERGSFVGNLAKDLGLEV---GEL-AARGARVVSK-GNKQYFQLNPETGDLLLNE-KLDREELC 67
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 254-319 6.17e-06

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 45.60  E-value: 6.17e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 967506250   254 IEVSIPENAPVGTSVTQLhATD--ADIGE----NARIhfsfsnlVSNIAKRLFHLNSTTGLITIKEPLDREE 319
Cdd:pfam08266    2 IRYSVPEETERGSFVGNL-AKDlgLEVGElaarGARV-------VSKGNKQYFQLNPETGDLLLNEKLDREE 65
FAM47 pfam14642
FAM47 family; The function of this Chordate family of proteins is not known.
 1175-1242 1.14e-05

FAM47 family; The function of this Chordate family of proteins is not known.


Pssm-ID: 405345 [Multi-domain]  Cd Length: 257  Bit Score: 48.72  E-value: 1.14e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 967506250  1175 PPLSQASTHHHSPPVTQTIALCHSPPVTQTIALCHSPPPIQISALHHSPPLAQATALRHSPPSAQASA 1242
Cdd:pfam14642  190 PPETRVSCLPPEPPKTPVSSLRPEPPETGVSHLRPQPPKTQVSSLHLEPPETGVSHLRPEPPKTQVSS 257
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 254-351 6.47e-05

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 43.10  E-value: 6.47e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967506250  254 IEVSIPENAPVGTSVTQLhatDADIGENARIHFSFSNLVSNIAKRLFHLNSTTGLITIKEPLDREETPNHKLLVLA-SDG 332
Cdd:cd00031     2 PDGSAVEGRSRGSFRVSI---PTDLIASSGEIIKISAAGKEALPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAaSLG 78

                          90       100
                  ....*....|....*....|
gi 967506250  333 GLVPARAMVLV-NVTDVNDN 351
Cdd:cd00031    79 ANVPQTSSVFSiEVYDENDN 98
FAM47 pfam14642
FAM47 family; The function of this Chordate family of proteins is not known.
 1187-1254 3.67e-04

FAM47 family; The function of this Chordate family of proteins is not known.


Pssm-ID: 405345 [Multi-domain]  Cd Length: 257  Bit Score: 44.10  E-value: 3.67e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 967506250  1187 PPVTQTIALCHSPPVTQTIALCHSPPPIQISALHHSPPLAQATALRHSPPSAQASALCYSPPLAQAAA 1254
Cdd:pfam14642  190 PPETRVSCLPPEPPKTPVSSLRPEPPETGVSHLRPQPPKTQVSSLHLEPPETGVSHLRPEPPKTQVSS 257
DUF4958 pfam16319
Domain of unknown function (DUF4958); This family consists of uncharacterized proteins around ...
 608-774 4.60e-04

Domain of unknown function (DUF4958); This family consists of uncharacterized proteins around 720 residues in length and is mainly found in various Bacteroides species. The function of this protein is unknown.


Pssm-ID: 406670 [Multi-domain]  Cd Length: 731  Bit Score: 44.54  E-value: 4.60e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967506250   608 SILDENDGFTIDSKTGVIRPNISFDREKQESYTFYVKAedggRVSRSSSAKVTINVVDVNDNKpvFIVPPSNYSYELVlp 687
Cdd:pfam16319  292 SVSPAIDKIKIDENTGVLSVAAGHGLKKGEKYKISVCA----RNMYSEEGVVFENVFTLNIVE--FIEPIDNFYYENE-- 363

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967506250   688 stdPGTVVFQVIAVDNDTGMNAEVRYSIVGENTRD--LFEINETTGNIIMKEKCDVTdLGLHRVLVKA-NDLGQPDSLFs 764
Cdd:pfam16319  364 ---TNTIEVEYTIEPTIVFKGEEIKYTFIECEPELqkNIELDATTGAITMKKGNKLV-IGSYTMKVKAaNSKYSETANI- 438

                          170
                   ....*....|
gi 967506250   765 vvTVNLFVNE 774
Cdd:pfam16319  439 --TFKLTQNP 446
FAM47 pfam14642
FAM47 family; The function of this Chordate family of proteins is not known.
 1199-1265 7.05e-04

FAM47 family; The function of this Chordate family of proteins is not known.


Pssm-ID: 405345 [Multi-domain]  Cd Length: 257  Bit Score: 42.94  E-value: 7.05e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 967506250  1199 PPVTQTIALCHSPPPIQISALHHSPPLAQATALRHSPPSAQASALCYSPPlaqAAAICHGSPLPQVT 1265
Cdd:pfam14642  190 PPETRVSCLPPEPPKTPVSSLRPEPPETGVSHLRPQPPKTQVSSLHLEPP---ETGVSHLRPEPPKT 253
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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