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Conserved domains on  [gi|1622969495|ref|XP_014982902|]
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G2/mitotic-specific cyclin-B3 isoform X1 [Macaca mulatta]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_CCNB3_rpt1 cd20508
first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is ...
 1092-1232 3.26e-84

first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410212 [Multi-domain]  Cd Length: 142  Bit Score: 271.05  E-value: 3.26e-84
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969495 1092 DIDEDSS-DPSFNPMYAKEIFSYMKEREEQFILTDYMNKQIEITSDMRAILVDWLVEVQVSFEMTHETLYLAVKLVDLYL 1170
Cdd:cd20508      1 DIDEENSdDPFQVSEYAKDIFDYMKEREEKFVVPDYLEKQTELTPSMRAILVDWLVEVQENFELNHETLYLAVKLVDLYL 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622969495 1171 MKAVCKKDKLQLLGATAFMIAAKFEEHHPPCVDDFVYICDDNYQRYEMLNVEIDILNVLKFD 1232
Cdd:cd20508     81 SKKVVKKEKLQLLGATAILIASKFDERCPPCVDDFLYICDDAYTREELLKMEREILKTLDFD 142
CYCLIN_SF super family cl40454
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 1236-1350 2.01e-53

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


The actual alignment was detected with superfamily member cd20510:

Pssm-ID: 477360  Cd Length: 115  Bit Score: 182.10  E-value: 2.01e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969495 1236 PVAYHFLRRYARCIHTNMKTLTLSRYICEMTLQEYNYVQEKASKLAAASLLLALYMKKLGYWVPFLEYYSGYSISELHPL 1315
Cdd:cd20510      1 PLSYRFLRRYAKCARASMETLTLARYILELSLMEYQFVQERASKLAAAALLLALKMKNLGEWTPTLEYYSGYSAEDLLPL 80

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1622969495 1316 VRRLNKLLTFSSYDSLKAVYYKYSHPVFFEVAKIP 1350
Cdd:cd20510     81 VRKLNAMLTKPPNKKLKTVRSKYSHKVFFEVAKIP 115
 
Name Accession Description Interval E-value
CYCLIN_CCNB3_rpt1 cd20508
first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is ...
 1092-1232 3.26e-84

first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410212 [Multi-domain]  Cd Length: 142  Bit Score: 271.05  E-value: 3.26e-84
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969495 1092 DIDEDSS-DPSFNPMYAKEIFSYMKEREEQFILTDYMNKQIEITSDMRAILVDWLVEVQVSFEMTHETLYLAVKLVDLYL 1170
Cdd:cd20508      1 DIDEENSdDPFQVSEYAKDIFDYMKEREEKFVVPDYLEKQTELTPSMRAILVDWLVEVQENFELNHETLYLAVKLVDLYL 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622969495 1171 MKAVCKKDKLQLLGATAFMIAAKFEEHHPPCVDDFVYICDDNYQRYEMLNVEIDILNVLKFD 1232
Cdd:cd20508     81 SKKVVKKEKLQLLGATAILIASKFDERCPPCVDDFLYICDDAYTREELLKMEREILKTLDFD 142
CYCLIN_CCNB3_rpt2 cd20510
second cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 ...
 1236-1350 2.01e-53

second cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410214  Cd Length: 115  Bit Score: 182.10  E-value: 2.01e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969495 1236 PVAYHFLRRYARCIHTNMKTLTLSRYICEMTLQEYNYVQEKASKLAAASLLLALYMKKLGYWVPFLEYYSGYSISELHPL 1315
Cdd:cd20510      1 PLSYRFLRRYAKCARASMETLTLARYILELSLMEYQFVQERASKLAAAALLLALKMKNLGEWTPTLEYYSGYSAEDLLPL 80

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1622969495 1316 VRRLNKLLTFSSYDSLKAVYYKYSHPVFFEVAKIP 1350
Cdd:cd20510     81 VRKLNAMLTKPPNKKLKTVRSKYSHKVFFEVAKIP 115
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 1109-1234 1.02e-45

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 160.76  E-value: 1.02e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969495 1109 EIFSYMKEREEQF-ILTDYMNKQIEITSDMRAILVDWLVEVQVSFEMTHETLYLAVKLVDLYLMKAVCKKDKLQLLGATA 1187
Cdd:pfam00134    1 DIFQYLRELELKYlPKPDYMDQQPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVTC 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1622969495 1188 FMIAAKFEEHHPPCVDDFVYICDDNYQRYEMLNVEIDILNVLKFDIN 1234
Cdd:pfam00134   81 LFIAAKYEEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
1084-1343 8.05e-44

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 166.10  E-value: 8.05e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969495 1084 KEQITPWEDID-EDSSDPSFNPMYAKEIFSYMKEREEQFILT-DYMNKQIEITSDMRAILVDWLVEVQVSFEMTHETLYL 1161
Cdd:COG5024    157 KRESQSWQDLDaTDQEDPLMVPEYASDIFEYLLKLELIDLPNpNYLIKQSLYEWSMRSILVDWLVEVHGKFGLLPETLFL 236

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969495 1162 AVKLVDLYLMKAVCKKDKLQLLGATAFMIAAKFEEHHPPCVDDFVYICDDNYQRYEMLNVEIDILNVLKFDINIPVAYHF 1241
Cdd:COG5024    237 AINIIDRFLSSRVVSLEKYQLVGISALFIASKYEEVNCPSIKDLVYATDGAFTRDDIIRAERYMLEVLDFNISWPSPMSF 316

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969495 1242 LRRYARCIHTNMKTLTLSRYICEMTLQEYNYVQEKASKLAAASLLLALYMKKLGYWVPFLEYYSG-YSISELHPLVRRLN 1320
Cdd:COG5024    317 LRRISKASDYDIFSRTPAKFSSEISPVDYKFIQISPSWCAAAAMYLSRKILSQNQWDRTLIHYSGnYTNPDLKPLNESNK 396

                          250       260
                   ....*....|....*....|...
gi 1622969495 1321 KLLtFSSYDSLKAVYYKYSHPVF 1343
Cdd:COG5024    397 ENL-QNPSVHHDAIFPKYPSPTF 418
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 1236-1352 1.33e-20

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 88.45  E-value: 1.33e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969495 1236 PVAYHFLRRYARCIH--TNMKTLTLSRYICEMTLQEYNYVQEKASKLAAASLLLALYMKKLGYWVPFLEYYSGYSISELH 1313
Cdd:pfam02984    1 PTPLSFLRRFSKAADylHDLELRTLAKYLLELTLLDYDFLKYPPSLIAAAAVYLARKTLNSPEWTETLEHYTGYSEEDLK 80

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1622969495 1314 PLVRRLNKLLTFSSYDSLKAVYYKYSHPVFFEVAKIPAL 1352
Cdd:pfam02984   81 PCVKLLLELLLNAPSSKLQAVRRKYSSSKFMKVSTLPPL 119
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 1143-1227 1.12e-17

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 78.79  E-value: 1.12e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969495  1143 DWLVEVQVSFEMTHETLYLAVKLVDLYLMKAVCKKDKLQLLGATAFMIAAKFEEHHPPCVDDFVYICDdnYQRYEMLNVE 1222
Cdd:smart00385    1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGY--FTEEEILRME 78


                    ....*
gi 1622969495  1223 IDILN 1227
Cdd:smart00385   79 RLLLE 83
 
Name Accession Description Interval E-value
CYCLIN_CCNB3_rpt1 cd20508
first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is ...
 1092-1232 3.26e-84

first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410212 [Multi-domain]  Cd Length: 142  Bit Score: 271.05  E-value: 3.26e-84
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969495 1092 DIDEDSS-DPSFNPMYAKEIFSYMKEREEQFILTDYMNKQIEITSDMRAILVDWLVEVQVSFEMTHETLYLAVKLVDLYL 1170
Cdd:cd20508      1 DIDEENSdDPFQVSEYAKDIFDYMKEREEKFVVPDYLEKQTELTPSMRAILVDWLVEVQENFELNHETLYLAVKLVDLYL 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622969495 1171 MKAVCKKDKLQLLGATAFMIAAKFEEHHPPCVDDFVYICDDNYQRYEMLNVEIDILNVLKFD 1232
Cdd:cd20508     81 SKKVVKKEKLQLLGATAILIASKFDERCPPCVDDFLYICDDAYTREELLKMEREILKTLDFD 142
CYCLIN_CCNB3_rpt2 cd20510
second cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 ...
 1236-1350 2.01e-53

second cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410214  Cd Length: 115  Bit Score: 182.10  E-value: 2.01e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969495 1236 PVAYHFLRRYARCIHTNMKTLTLSRYICEMTLQEYNYVQEKASKLAAASLLLALYMKKLGYWVPFLEYYSGYSISELHPL 1315
Cdd:cd20510      1 PLSYRFLRRYAKCARASMETLTLARYILELSLMEYQFVQERASKLAAAALLLALKMKNLGEWTPTLEYYSGYSAEDLLPL 80

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1622969495 1316 VRRLNKLLTFSSYDSLKAVYYKYSHPVFFEVAKIP 1350
Cdd:cd20510     81 VRKLNAMLTKPPNKKLKTVRSKYSHKVFFEVAKIP 115
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 1106-1231 4.25e-50

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 173.10  E-value: 4.25e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969495 1106 YAKEIFSYMKEREEQF-ILTDYMNKQIEITSDMRAILVDWLVEVQVSFEMTHETLYLAVKLVDLYLMKAVCKKDKLQLLG 1184
Cdd:cd20507      4 YVKDIYKYLRQLEKKYaIDPDYLSGQPEITERMRAILVDWLVEVHLKFKLLPETLYLTVNIIDRYLSKKQVPRKKLQLVG 83

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1622969495 1185 ATAFMIAAKFEEHHPPCVDDFVYICDDNYQRYEMLNVEIDILNVLKF 1231
Cdd:cd20507     84 VTALLIASKYEEIYPPEIKDFVYITDNAYTREEILQMERDILKTLDF 130
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 1109-1234 1.02e-45

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 160.76  E-value: 1.02e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969495 1109 EIFSYMKEREEQF-ILTDYMNKQIEITSDMRAILVDWLVEVQVSFEMTHETLYLAVKLVDLYLMKAVCKKDKLQLLGATA 1187
Cdd:pfam00134    1 DIFQYLRELELKYlPKPDYMDQQPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVTC 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1622969495 1188 FMIAAKFEEHHPPCVDDFVYICDDNYQRYEMLNVEIDILNVLKFDIN 1234
Cdd:pfam00134   81 LFIAAKYEEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
1084-1343 8.05e-44

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 166.10  E-value: 8.05e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969495 1084 KEQITPWEDID-EDSSDPSFNPMYAKEIFSYMKEREEQFILT-DYMNKQIEITSDMRAILVDWLVEVQVSFEMTHETLYL 1161
Cdd:COG5024    157 KRESQSWQDLDaTDQEDPLMVPEYASDIFEYLLKLELIDLPNpNYLIKQSLYEWSMRSILVDWLVEVHGKFGLLPETLFL 236

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969495 1162 AVKLVDLYLMKAVCKKDKLQLLGATAFMIAAKFEEHHPPCVDDFVYICDDNYQRYEMLNVEIDILNVLKFDINIPVAYHF 1241
Cdd:COG5024    237 AINIIDRFLSSRVVSLEKYQLVGISALFIASKYEEVNCPSIKDLVYATDGAFTRDDIIRAERYMLEVLDFNISWPSPMSF 316

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969495 1242 LRRYARCIHTNMKTLTLSRYICEMTLQEYNYVQEKASKLAAASLLLALYMKKLGYWVPFLEYYSG-YSISELHPLVRRLN 1320
Cdd:COG5024    317 LRRISKASDYDIFSRTPAKFSSEISPVDYKFIQISPSWCAAAAMYLSRKILSQNQWDRTLIHYSGnYTNPDLKPLNESNK 396

                          250       260
                   ....*....|....*....|...
gi 1622969495 1321 KLLtFSSYDSLKAVYYKYSHPVF 1343
Cdd:COG5024    397 ENL-QNPSVHHDAIFPKYPSPTF 418
CYCLIN_CCNA_rpt1 cd20504
first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 1106-1231 1.09e-43

first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. The model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410208 [Multi-domain]  Cd Length: 128  Bit Score: 154.71  E-value: 1.09e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969495 1106 YAKEIFSYMKEREEQFI-LTDYMNKQIEITSDMRAILVDWLVEVQVSFEMTHETLYLAVKLVDLYLMKAVCKKDKLQLLG 1184
Cdd:cd20504      2 YADDIYEYLRESELKHRpKPDYMRKQPDINPSMRSILVDWLVEVAEEYKLVPETLYLAVNYIDRFLSQMSVLRSKLQLVG 81

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1622969495 1185 ATAFMIAAKFEEHHPPCVDDFVYICDDNYQRYEMLNVEIDILNVLKF 1231
Cdd:cd20504     82 TACMFIAAKYEEIYPPEVEEFVYITDDTYTKKQVLRMEHLVLKVLSF 128
CYCLIN_CLBs_yeast_rpt1 cd20568
first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces ...
 1099-1231 2.69e-40

first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transitions. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410271  Cd Length: 134  Bit Score: 145.52  E-value: 2.69e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969495 1099 DPSFNPMYAKEIFSYMKEREEQFILT-DYMNKQIEITSDMRAILVDWLVEVQVSFEMTHETLYLAVKLVDLYLMKAVCKK 1177
Cdd:cd20568      1 DPLMVAEYVPEIFEYLRELELKTLPNpNYMDDQKELRWKMRGILVDWLVEVHEKFRLLPETLFLAVNIIDRFLSKRVVSL 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1622969495 1178 DKLQLLGATAFMIAAKFEEHHPPCVDDFVYICDDNYQRYEMLNVEIDILNVLKF 1231
Cdd:cd20568     81 NKLQLVGISALFIASKYEEVNSPSIKNFAYMTDGAYTVEDILRAERYMLNTLEF 134
CYCLIN_AtCycB-like_rpt1 cd20567
first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 1092-1231 1.76e-39

first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410270  Cd Length: 147  Bit Score: 143.64  E-value: 1.76e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969495 1092 DIDE-DSSDPSFNPMYAKEIFSYMKEREEQF-ILTDYMNKQIEITSDMRAILVDWLVEVQVSFEMTHETLYLAVKLVDLY 1169
Cdd:cd20567      6 DIDEvDKNNPLAAVEYVEDIYSFYRKVEPEScVPPYYMSQQPDINEKMRAILIDWLIEVHLKFELMPETLYLTVNLIDRF 85

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622969495 1170 L-MKAVCKKdKLQLLGATAFMIAAKFEEHHPPCVDDFVYICDDNYQRYEMLNVEIDILNVLKF 1231
Cdd:cd20567     86 LsVKQVPRK-ELQLVGVTAMLIASKYEEIWAPEVNDFVYISDNAYTRKQILVMEKTMLNTLEF 147
CYCLIN_AtCycA_like_rpt1 cd20562
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 1099-1232 3.36e-39

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410265  Cd Length: 136  Bit Score: 142.55  E-value: 3.36e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969495 1099 DPSFNPMYAKEIFSYMKERE-EQFILTDYMNK-QIEITSDMRAILVDWLVEVQVSFEMTHETLYLAVKLVDLYLMKAVCK 1176
Cdd:cd20562      1 DPQMCSLYATDIYLNLRVAElKRRPLPDYMEKiQRDITPSMRGILVDWLVEVAEEYKLVPDTLYLTVSYIDRFLSGNYVN 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622969495 1177 KDKLQLLGATAFMIAAKFEEHHPPCVDDFVYICDDNYQRYEMLNVEIDILNVLKFD 1232
Cdd:cd20562     81 RQRLQLLGVSCMLIASKYEEICAPQVEEFCYITDNTYTKQEVLEMEIDVLNALQFE 136
CYCLIN_CCNA2_rpt1 cd20561
first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S ...
 1104-1232 7.87e-34

first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly over-expressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410264 [Multi-domain]  Cd Length: 131  Bit Score: 126.71  E-value: 7.87e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969495 1104 PMYAKEIFSYMKEREEQFI-LTDYMNKQIEITSDMRAILVDWLVEVQVSFEMTHETLYLAVKLVDLYLMKAVCKKDKLQL 1182
Cdd:cd20561      2 PDYHEDIHTYLREMEVKCKpKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQL 81

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1622969495 1183 LGATAFMIAAKFEEHHPPCVDDFVYICDDNYQRYEMLNVEIDILNVLKFD 1232
Cdd:cd20561     82 VGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFD 131
CYCLIN_CCNA1_rpt1 cd20560
first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of ...
 1088-1232 5.57e-33

first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410263  Cd Length: 163  Bit Score: 125.72  E-value: 5.57e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969495 1088 TPWEDIDEDSSDPSFNPMYAKEIFSYMKEREEQF-ILTDYMNKQIEITSDMRAILVDWLVEVQVSFEMTHETLYLAVKLV 1166
Cdd:cd20560     18 SQSEDDSAADVDVLAVPEYAEDIHQYLREAELKHrPKPGYMRKQPDITTGMRTILVDWLVEVGEEYKLQTETLYLAVNYL 97

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622969495 1167 DLYLMKAVCKKDKLQLLGATAFMIAAKFEEHHPPCVDDFVYICDDNYQRYEMLNVEIDILNVLKFD 1232
Cdd:cd20560     98 DRFLSCMSVLRGKLQLVGTAAILLASKYEEIYPPEVDEFVYITDDTYTKKQLLRMEHLLLKVLAFD 163
CYCLIN_CCNB1_rpt1 cd20565
first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the ...
 1106-1231 1.75e-30

first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410268 [Multi-domain]  Cd Length: 129  Bit Score: 117.29  E-value: 1.75e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969495 1106 YAKEIFSYMKERE-EQFILTDYMNKQiEITSDMRAILVDWLVEVQVSFEMTHETLYLAVKLVDLYLMKAVCKKDKLQLLG 1184
Cdd:cd20565      4 YVKDIYAYLRQLEeEQAVRPKYLEGQ-EVTGNMRAILIDWLVQVQMKFRLLQETMYMTVAIIDRFLQNNPVPKKMLQLVG 82

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1622969495 1185 ATAFMIAAKFEEHHPPCVDDFVYICDDNYQRYEMLNVEIDILNVLKF 1231
Cdd:cd20565     83 VTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALDF 129
CYCLIN_CCNB2_rpt1 cd20566
first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is ...
 1099-1231 1.13e-28

first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410269 [Multi-domain]  Cd Length: 133  Bit Score: 112.26  E-value: 1.13e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969495 1099 DPSFNPMYAKEIFSYMKERE-EQFILTDYMNKQiEITSDMRAILVDWLVEVQVSFEMTHETLYLAVKLVDLYLMKAVCKK 1177
Cdd:cd20566      1 NPQLCSDYVKDIYQYLRQLEvQQSIRPHYLDGK-EINERMRAILVDWLVQVHSRFQLLQETLYMCVAIMDRFLQVQPVSR 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1622969495 1178 DKLQLLGATAFMIAAKFEEHHPPCVDDFVYICDDNYQRYEMLNVEIDILNVLKF 1231
Cdd:cd20566     80 KKLQLVGVTALLLASKYEEMYSPEIGDFVYITDNAYTKAQIREMEMLILKELNF 133
CYCLIN_CCNE_rpt1 cd20519
first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 1108-1231 1.95e-27

first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410223  Cd Length: 131  Bit Score: 108.55  E-value: 1.95e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969495 1108 KEIFSYMKEREEQFILT-DYMNKQIEITSDMRAILVDWLVEVQVSFEMTHETLYLAVKLVDLYL-MKAVCKKDKLQLLGA 1185
Cdd:cd20519      6 EEVWDLMLKKEELYKRDrDFLNRHPSLQPRMRAILLDWLMEVCEVYRLHRETFYLAVDFVDRYLsTQTNVPKTQLQLIGI 85

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1622969495 1186 TAFMIAAKFEEHHPPCVDDFVYICDDNYQRYEMLNVEIDILNVLKF 1231
Cdd:cd20519     86 TCLFIAAKLEEIYPPKLSEFAYVTDGACTEDEILTMELIILKALNW 131
CYCLIN_CCNO_rpt1 cd20536
first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required ...
 1137-1229 6.32e-27

first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410239  Cd Length: 93  Bit Score: 105.87  E-value: 6.32e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969495 1137 MRAILVDWLVEVQVSFEMTHETLYLAVKLVDLYLMKAVCKKDKLQLLGATAFMIAAKFEEHHPPCVDDFVYICDDNYQRY 1216
Cdd:cd20536      1 MRAKLISWLIPVHRHFNLSQETLFLAVNILDRFLATTPVARDCFQLLGVTSLLIACKQEEIYPPEVKDLLALCCGAYTRE 80

                           90
                   ....*....|...
gi 1622969495 1217 EMLNVEIDILNVL 1229
Cdd:cd20536     81 QICNLECIILTKL 93
CYCLIN_CNTD2 cd20542
cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; ...
 1138-1233 7.15e-27

cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; CNTD2 is an atypical cyclin upregulated in human cancer tissues. It promotes cell proliferation and migration, as well as increases tumor growth in vivo. It can function as a prognostic factor and drug target. CNTD2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410245 [Multi-domain]  Cd Length: 96  Bit Score: 105.48  E-value: 7.15e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969495 1138 RAILVDWLVEVQVSFEMTHETLYLAVKLVDLYLMKAVCKKDKLQLLGATAFMIAAKFEEHHPPCVDDFVYICDDNYQRYE 1217
Cdd:cd20542      1 RAILVDWLVQVQEHLELSTQTLHLAVALLDRYLSRQKISLSLLQLLGITCLFIACKFEERFPPEVATLCYLTDDSYSKKQ 80

                           90
                   ....*....|....*.
gi 1622969495 1218 MLNVEIDILNVLKFDI 1233
Cdd:cd20542     81 VLRMERRVLRRLRFDL 96
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 1236-1352 1.33e-20

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 88.45  E-value: 1.33e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969495 1236 PVAYHFLRRYARCIH--TNMKTLTLSRYICEMTLQEYNYVQEKASKLAAASLLLALYMKKLGYWVPFLEYYSGYSISELH 1313
Cdd:pfam02984    1 PTPLSFLRRFSKAADylHDLELRTLAKYLLELTLLDYDFLKYPPSLIAAAAVYLARKTLNSPEWTETLEHYTGYSEEDLK 80

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1622969495 1314 PLVRRLNKLLTFSSYDSLKAVYYKYSHPVFFEVAKIPAL 1352
Cdd:pfam02984   81 PCVKLLLELLLNAPSSKLQAVRRKYSSSKFMKVSTLPPL 119
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 1143-1227 1.12e-17

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 78.79  E-value: 1.12e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969495  1143 DWLVEVQVSFEMTHETLYLAVKLVDLYLMKAVCKKDKLQLLGATAFMIAAKFEEHHPPCVDDFVYICDdnYQRYEMLNVE 1222
Cdd:smart00385    1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGY--FTEEEILRME 78


                    ....*
gi 1622969495  1223 IDILN 1227
Cdd:smart00385   79 RLLLE 83
CYCLIN_CCNE1_rpt1 cd20579
first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 1109-1231 3.78e-17

first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410282 [Multi-domain]  Cd Length: 137  Bit Score: 79.54  E-value: 3.78e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969495 1109 EIFSYMKEREEQFIL-TDYMNKQIEITSDMRAILVDWLVEVQVSFEMTHETLYLAVKLVDLYL-MKAVCKKDKLQLLGAT 1186
Cdd:cd20579     13 EVWKNMLNKDKTYLRdKNFLQKHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRFMaTQENVVKTRLQLIGIS 92

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1622969495 1187 AFMIAAKFEEHHPPCVDDFVYICDDNYQRYEMLNVEIDILNVLKF 1231
Cdd:cd20579     93 SLFIAAKLEEIYPPKLHQFAYVTDGACTEDEILSMELIIMKALKW 137
CYCLIN_CCNB1-like_rpt2 cd20509
second cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 1236-1346 5.92e-16

second cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410213  Cd Length: 111  Bit Score: 74.96  E-value: 5.92e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969495 1236 PVAYHFLRRYARCIHTNMKTLTLSRYICEMTLQEYNYVQEKASKLAAASLLLALYMKKLGYWVPFLEYYSGYSISELHPL 1315
Cdd:cd20509      1 PLPLHFLRRFSKAGGADAQKHTLAKYLMELTLLDYDMVHYKPSEIAAAALCLSRKILDEPEWTPTLEHYSTYSEEDLLPI 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1622969495 1316 VRRLNKLLTFSSYDSLKAVYYKYSHPVFFEV 1346
Cdd:cd20509     81 VQKMAKLVVKSQTSKYQAVKNKYSSSKFMRI 111
CYCLIN_CCNE2_rpt1 cd20580
first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control ...
 1107-1231 1.82e-15

first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410283 [Multi-domain]  Cd Length: 137  Bit Score: 74.50  E-value: 1.82e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969495 1107 AKEIFSYMKEREEQFI-LTDYMNKQIEITSDMRAILVDWLVEVQVSFEMTHETLYLAVKLVDLYLM-KAVCKKDKLQLLG 1184
Cdd:cd20580     11 SKDVWLNMLKKESKYVhDKHFLQLHPALQPKMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLtQKNINKSMLQLIG 90

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1622969495 1185 ATAFMIAAKFEEHHPPCVDDFVYICDDNYQRYEMLNVEIDILNVLKF 1231
Cdd:cd20580     91 ITSLFIASKLEEIYPPKLHEFAYVTDGACSEDDILDMELIILKALKW 137
CYCLIN_CCNF_rpt1 cd20521
first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also ...
 1137-1217 8.80e-15

first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410225  Cd Length: 95  Bit Score: 71.19  E-value: 8.80e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969495 1137 MRAILVDWLVEVQVSFEMTHETLYLAVKLVDLYLMKAVCKKDKLQLLGATAFMIAAKFEEHHPPCVDDFVYICDDNYqRY 1216
Cdd:cd20521      3 MRYILVDWLVEVATMKDFSSLTLHVAVSCVDRYLMVRKVPRSKLQLLGIACMVIATRFLGKDILTIREAAWLTDNTY-KY 81


                   .
gi 1622969495 1217 E 1217
Cdd:cd20521     82 E 82
CYCLIN_ScCLN_like cd20559
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar ...
 1141-1232 1.45e-14

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar proteins; ScCLNs, including ScCLN1-3, are essential for the control of the cell cycle at the G1/S (start) transition in Saccharomyces. ScCLN1 and ScCLN2 interact with the CDC28 protein kinase to form maturation promoting factor (MPF). ScCLN3 may be an upstream activator of the G1 cyclins that directly initiate G1/S transition. This family also includes Schizosaccharomyces pombe cyclin puc1, which contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. It interacts with protein kinase A. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410262 [Multi-domain]  Cd Length: 95  Bit Score: 70.49  E-value: 1.45e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969495 1141 LVDWLVEVQVSFEMTHETLYLAVKLVDLYLMKAVCKKDKLQLLGATAFMIAAKFEEHHP--PCVDDFVYICDDNYQRYEM 1218
Cdd:cd20559      2 LLDFLFELHVELRLSPQTFFLSVNLIDRYCSKRIVLKKHYQLVGCTCLWIASKFWESKArvPLLSELSKMCCNSYGEELF 81

                           90
                   ....*....|....
gi 1622969495 1219 LNVEIDILNVLKFD 1232
Cdd:cd20559     82 IQMEMHILNTLNWD 95
CYCLIN_CCNJ-like_rpt1 cd20528
first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 1137-1231 1.49e-11

first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410231 [Multi-domain]  Cd Length: 103  Bit Score: 62.24  E-value: 1.49e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969495 1137 MRAILVDWLVEVQVSFEMTHETLYLAVKLVDLYLMKAVCKKDKLQLLGATAFMIAAKFEE--HHPPCVDDFV-YICDDNY 1213
Cdd:cd20528      6 LRRYLVDWLAVVSERLKLSDTTLHLAVYLLDRFMDRYDISEDQLHLVALTCLLLAAKFEEldDNIPKISDLNrYLCNSVY 85

                           90
                   ....*....|....*...
gi 1622969495 1214 QRYEMLNVEIDILNVLKF 1231
Cdd:cd20528     86 SKQEYLQMELLILEFFQW 103
CYCLIN_vCyC_rpt1 cd20517
first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle ...
 1133-1231 3.52e-11

first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle progression and apoptotic signaling pathways. It forms an active kinase complex with cellular CDK6, a cellular cyclin-dependent kinase known to interact with cellular type D cyclins. v-Cyclin belongs to Cyclin D subfamily. It contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410221  Cd Length: 99  Bit Score: 61.04  E-value: 3.52e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969495 1133 ITSDMRAILVDWLVEVQVSFEMTHETLYLAVKLVDLYLMKAVCKKDKLQLLGATAFMIAAKFEEHHPPCVDDFVYICDDN 1212
Cdd:cd20517      1 VTSDNRKILLTWMFLVCESFELDKNVFPLAVSLLDRLLLKKQGTKETLQKTGAACLLIASKIRTVKPITVSKLTYLSCDC 80

                           90
                   ....*....|....*....
gi 1622969495 1213 YQRYEMLNVEIDILNVLKF 1231
Cdd:cd20517     81 FTNLELINQEKDILEALKW 99
CYCLIN_CCND3_rpt1 cd20575
first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a ...
 1130-1232 4.18e-11

first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410278  Cd Length: 150  Bit Score: 62.31  E-value: 4.18e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969495 1130 QIEITSDMRAILVDWLVEVQVSFEMTHETLYLAVKLVDLYLMKAVCKKDKLQLLGATAFMIAAKFEEHHPPCVDDFVYIC 1209
Cdd:cd20575     48 QREIKPYMRKMLAYWMLEVCEEQKCEEEVFPLAMNYVDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYT 127

                           90       100
                   ....*....|....*....|...
gi 1622969495 1210 DDNYQRYEMLNVEIDILNVLKFD 1232
Cdd:cd20575    128 DNSISPRQLLDWEILVLGKLKWD 150
CYCLIN_CCND_rpt1 cd20515
first cyclin box found in cyclin-D (CCND) family; The CCND family includes three ...
 1118-1232 4.62e-11

first cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410219  Cd Length: 150  Bit Score: 62.32  E-value: 4.62e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969495 1118 EEQFIL-TDYMNK-QIEITSDMRAILVDWLVEVQVSFEMTHETLYLAVKLVDLYLMKAVCKKDKLQLLGATAFMIAAKFE 1195
Cdd:cd20515     34 EERYLPsASYFKCvQTEIQPFMRKMVTTWMLEVCEEQNCEEEVFPLAVNYLDRFLSLVPIRKSQLQLLGAVCLFLASKLK 113

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1622969495 1196 EHHPPCVDDFVYICDDNYQRYEMLNVEIDILNVLKFD 1232
Cdd:cd20515    114 ETIPLTAEKLCIYTDNSITLQELLDWELLVLTKLKWD 150
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 1141-1224 1.19e-10

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 58.96  E-value: 1.19e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969495 1141 LVDWLVEVQVSFEMTHETLYLAVKLVDLYLMKAVCKKDKLQLLGATAFMIAAKFEEHHPPcVDDFVYICddNYQRYEMLN 1220
Cdd:cd00043      2 AVDFIRRLCSKLGLPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACKLEELPRT-LKEIAKVS--GVSEKELRK 78


                   ....
gi 1622969495 1221 VEID 1224
Cdd:cd00043     79 AEKE 82
CYCLIN_CCND1_rpt1 cd20573
first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma ...
 1130-1232 6.45e-10

first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1. The complex also regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410276  Cd Length: 149  Bit Score: 58.84  E-value: 6.45e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969495 1130 QIEITSDMRAILVDWLVEVQVSFEMTHETLYLAVKLVDLYLMKAVCKKDKLQLLGATAFMIAAKFEEHHPPCVDDFVYIC 1209
Cdd:cd20573     47 QKEILPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSVEPTKKSRLQLLGATCMFLASKMKETIPLTAEKLCIYT 126

                           90       100
                   ....*....|....*....|...
gi 1622969495 1210 DDNYQRYEMLNVEIDILNVLKFD 1232
Cdd:cd20573    127 DNSIRPEELLQMELLVLNKLKWD 149
CYCLIN_AtCycA-like_rpt2 cd20506
second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 1241-1343 1.09e-09

second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410210  Cd Length: 111  Bit Score: 57.26  E-value: 1.09e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969495 1241 FLRRY---ARCIHTNMKTLTLSRYICEMTLQEYNYVQEKASKLAAASLLLALYMKKLGYWVPFLEYYSGYSISELHPLVR 1317
Cdd:cd20506      6 FLRRFlraAQASVPDLKLEFLANYLAELSLLDYEFLKYLPSLIAASAVFLARHTLNPHPWNPTLEHYTGYKAADLKPCVQ 85

                           90       100
                   ....*....|....*....|....*.
gi 1622969495 1318 RLNKLLTFSSYDSLKAVYYKYSHPVF 1343
Cdd:cd20506     86 ALHDLQLNASGSSLQAVREKYKQHKF 111
CYCLIN_AtCycB-like_rpt2 cd20511
second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 1236-1350 5.70e-08

second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410215  Cd Length: 117  Bit Score: 52.31  E-value: 5.70e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969495 1236 PVAYHFLRRYARCIHTNMKTLTLSRYICEMTLQEYNYVQEKASKLAAASLLLALY-MKKLGYWVPFLEYYSGYSISELHP 1314
Cdd:cd20511      1 PTPYVFLVRFLKAAQSDKKLENLAFFLVELGLVEYEMLKYSPSMLAASAVYTARCtLNKTPEWTSTLEFHTGYSESQLME 80

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1622969495 1315 LVRRLNKLLTFSSYDSLKAVYYKYSHPVFFEVAKIP 1350
Cdd:cd20511     81 CARLMVRLHSKAGTGKLTAVYKKYSSSKFGAVALLP 116
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 1138-1230 1.89e-07

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410246  Cd Length: 99  Bit Score: 50.39  E-value: 1.89e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969495 1138 RAILVDWLVEVQVSFEMTHETLYLAVKLVDLYLMKAVCKKDK---LQLLGATAFMIAAKFEEHHPPCVDDF-----VYIC 1209
Cdd:cd20543      2 RNEAIDWILKVRSRYGFGPLTAYLAVNYLDRFLSSYDLPKDKpwmLQLLAVACLSLAAKMEETDVPLLVDLqveepKYVF 81

                           90       100
                   ....*....|....*....|..
gi 1622969495 1210 D-DNYQRYEMLnveidILNVLK 1230
Cdd:cd20543     82 EaKTIQRMELL-----VLSTLE 98
CYCLIN_CCND2_rpt1 cd20574
first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of ...
 1100-1232 2.52e-07

first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410277  Cd Length: 150  Bit Score: 51.53  E-value: 2.52e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969495 1100 PSFNPMYAKEIFSYMKEREEQFI--LTDYMNKQIEITSDMRAILVDWLVEVQVSFEMTHETLYLAVKLVDLYLMKAVCKK 1177
Cdd:cd20574     16 PDPNLLYDDRVLQNLLTIEERYLpqCSYFKCVQKDIQPFMRRMVATWMLEVCEEQKCEEEVFPLAMNYLDRFLAVVPTRK 95

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1622969495 1178 DKLQLLGATAFMIAAKFEEHHPPCVDDFVYICDDNYQRYEMLNVEIDILNVLKFD 1232
Cdd:cd20574     96 CHLQLLGAVCMFLASKLKETIPLTAEKLCIYTDNSIKPQELLEWELVVLGKLKWN 150
CYCLIN_CCNO-like_rpt2 cd20537
second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of ...
 1236-1323 5.13e-07

second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of CCNO and similar proteins including Schizosaccharomyces pombe meiosis-specific cyclin rem1, Drosophila melanogaster G2/mitotic-specific cyclin-A (CCNA), and Candida albicans G1/S-specific cyclin CCN1, among others. Rem1 is required for pre-meiotic DNA synthesis and S phase progression. CCNA is essential for the control of the cell cycle at the G2/M (mitosis) transition. CCN1 is essential for the control of the cell cycle at the G1/S (start) transition and for maintenance of filamentous growth. CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It is involved in the activation of cyclin-dependent kinase 2. Members of this subfamily contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410240 [Multi-domain]  Cd Length: 91  Bit Score: 48.84  E-value: 5.13e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969495 1236 PVAYHFLRRYARCIHTNMKTLTLSRYICEMTLQEYNYVQekasklaaaslllalY----------------MKKLGYWVP 1299
Cdd:cd20537      1 PTPLSFLRRYLSLLGLDEKVRHLARYLLELSLLDYEFLK---------------YrpsliaaaalylarkiLGEPPPSPQ 65

                           90       100
                   ....*....|....*....|....
gi 1622969495 1300 FLEYYSGYSISELHPLVRRLNKLL 1323
Cdd:cd20537     66 LLQLVTGYSENDLQECAKELLELL 89
CYCLIN_CCNA_rpt2 cd20505
second cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 1236-1341 2.62e-05

second cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410209 [Multi-domain]  Cd Length: 110  Bit Score: 44.59  E-value: 2.62e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969495 1236 PVAYHFLRRYARCIHTNMKTLTLSRYICEMTLQEYN-YVQEKASKLAAASLLLALYMKKLGYWVPFLEYYSGYSISELHP 1314
Cdd:cd20505      1 PTSNWFLERFLKHSNADEKTKSLAMYLCELSLIDADpYLKYLPSVIAAAAVCLANHTLGNEVWPQKLARSTGYSLEDLLP 80

                           90       100
                   ....*....|....*....|....*..
gi 1622969495 1315 LVRRLNKLLTFSSYDSLKAVYYKYSHP 1341
Cdd:cd20505     81 CLRDLHRTFLNAPSSPQQAIREKYKSS 107
CYCLIN_CCNA1_rpt2 cd20563
second cyclin box found in cyclin-A1 (CCNA1) and similar proteins; CCNA1 may primarily ...
 1236-1357 4.13e-04

second cyclin box found in cyclin-A1 (CCNA1) and similar proteins; CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410266  Cd Length: 123  Bit Score: 41.72  E-value: 4.13e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969495 1236 PVAYHFLRRYARCIHTNMKTLTLSRYICEMTLQEYN-YVQEKASKLAAASLLLALYMKKLGYWVPFLEYYSGYSISELHP 1314
Cdd:cd20563      1 PTINQFLLQYLKRHEVCEKTENLAMYVAELSLLEVDpFLKYLPSLTAAAAYCLANYTVNKVFWPETLAAFTGYSLSEIVP 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1622969495 1315 LVRRLNKLLTFSSYDSLKAVYYKYSHPVFFEVAKIPALDVLKL 1357
Cdd:cd20563     81 CLSDLHKACLGAPHRPQQAIREKYKGSKYMQVSLLEPPAVLPL 123
CYCLIN_CCNB2_rpt2 cd20570
second cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 ...
 1236-1352 4.36e-04

second cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410273  Cd Length: 119  Bit Score: 41.41  E-value: 4.36e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969495 1236 PVAYHFLRRYARCIHTNMKTLTLSRYICEMTLQEYNYVQEKASKLAAASLLLALYMKKLGYWVPFLEYYSGYSISELHPL 1315
Cdd:cd20570      1 PLPLHFLRRASKAGSADVEKHTLAKYLMELTLIDYDMVHYHPSEIAAAALCLSQKVLDGGKWSLTQQYYTGYTEDDLKPI 80

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1622969495 1316 VRRLNKLLTFSSYDSLK--AVYYKYSHPVFFEVAKIPAL 1352
Cdd:cd20570     81 MQHMAKNVVKVNEGLTKhvAVKNKYASSKLMKISTIPQL 119
CYCLIN_CCNB1_rpt2 cd20569
second cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1) and similar proteins; CCNB1 ...
 1236-1321 6.39e-04

second cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1) and similar proteins; CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410272  Cd Length: 121  Bit Score: 41.03  E-value: 6.39e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969495 1236 PVAYHFLRRYARCIHTNMKTLTLSRYICEMTLQEYNYVQEKASKLAAASLLLALYMKKLGYWVPFLEYYSGYSISELHPL 1315
Cdd:cd20569      1 PLPLHFLRRASKIGEVDVEQHTLAKYLMELTMVDYDMVHFPPSQIAAAAFCLALKILDNGEWTPTLQHYMSYTEESLLPV 80


                   ....*.
gi 1622969495 1316 VRRLNK 1321
Cdd:cd20569     81 MQHMAK 86
CYCLIN_CCNI-like cd20526
cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because ...
 1142-1233 8.89e-03

cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because it is most abundant in post-mitotic cells. It is involved in various biological processes, such as cell survival, angiogenesis, cell differentiation, and cell cycle progression. CCNI contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. The cyclin box is a protein binding domain.


Pssm-ID: 410230  Cd Length: 99  Bit Score: 37.29  E-value: 8.89e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622969495 1142 VDWLVEVQVSFEMTHETLYLAVKLVDLYLMKAVCKKDKLQLLGATAFMIAAKF--EEHHPPCVDDFVYICDDNYQRYEML 1219
Cdd:cd20526      6 VRWLAELNSQFKFYPETFALAVSILDRFLASVKARPKYLRCIAISCLFLAAKTneEDEVIPSTKDLVRVSKCGCSVAEVL 85

                           90
                   ....*....|....
gi 1622969495 1220 NVEIDILNVLKFDI 1233
Cdd:cd20526     86 RMERIILDKLHWDL 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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