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Conserved domains on  [gi|1622827025|ref|XP_014982719|]
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WD repeat-containing protein 64 isoform X3 [Macaca mulatta]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 13234759)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 205-459 4.86e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 100.49  E-value: 4.86e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827025  205 KLHNDWVMKIRYISALNCFGSCSLDSnhslvleSLK--RLEDNLPVREFsmpRGANTFCYCVKAN----VIVTGGDDKVI 278
Cdd:cd00200     48 KGHTGPVRDVAASADGTYLASGSSDK-------TIRlwDLETGECVRTL---TGHTSYVSSVAFSpdgrILSSSSRDKTI 117

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827025  279 RLWHpNISTKPVGKLVGHMFSITEIVTNEKDQHIVSLSSAKVFRVWDIQTLSLLQVFHDSQGgpgdmQIYSMIYDANHGM 358
Cdd:cd00200    118 KVWD-VETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTG-----EVNSVAFSPDGEK 191

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827025  359 LITGSSVMDMYPLTRMIQDTKQVPHTHEREINVMLY--NKYLhqvLTICSE-SIIRVWELETGLQVYQIldpHGFNIEVT 435
Cdd:cd00200    192 LLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFspDGYL---LASGSEdGTIRVWDLRTGECVQTL---SGHTNSVT 265

                          250       260
                   ....*....|....*....|....
gi 1622827025  436 SAAVDESGFFFATGAYNGTVRIWD 459
Cdd:cd00200    266 SLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
309-827 7.43e-10

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 62.24  E-value: 7.43e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827025  309 DQHIVSLSSAKVFRVWDIQTLSLLQVFHDSQGgpgdmQIYSMIYDANHGMLITGSSVMDMYPLTRMIQDTKQVPHTHERE 388
Cdd:COG2319      6 GAALAAASADLALALLAAALGALLLLLLGLAA-----AVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827025  389 INVMLYNKYLHQVLTICSESIIRVWELETGLQVYQILDPHGfniEVTSAAVDESGFFFATGAYNGTVRIWDFGSGQEMKV 468
Cdd:COG2319     81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTG---AVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRT 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827025  469 LLEGKDWkeeehcLQRLVFLKaqeKHQHLVLAlERNGTIKmiqgkeddiylmvIWELPD--VVPFLQDGKHAVH-LRVSt 545
Cdd:COG2319    158 LTGHSGA------VTSVAFSP---DGKLLASG-SDDGTVR-------------LWDLATgkLLRTLTGHTGAVRsVAFS- 213

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827025  546 rdrnmaipfPDvelivernasqpsnnpamdslrvncidllqveGyNLIAAGTLNGMIILWNFVTSTVKKVcrledcfpvn 625
Cdd:COG2319    214 ---------PD--------------------------------G-KLLASGSADGTVRLWDLATGKLLRT---------- 241

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827025  626 pdLHPKHFKINDILFlfrtpecarrssqdsicsssqceSSKGPQ--SskGSkqsiHDSEVKgeQTDVTVGEQQPVDKKHP 703
Cdd:COG2319    242 --LTGHSGSVRSVAF-----------------------SPDGRLlaS--GS----ADGTVR--LWDLATGELLRTLTGHS 288

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827025  704 GSAN----LPEAQppILVTAHEDGHLRLWTLE-GRLLKdmlPFTKHSAiSLTSLYTDSCTRILLAGNVEGHVILCNISSf 778
Cdd:COG2319    289 GGVNsvafSPDGK--LLASGSDDGTVRLWDLAtGKLLR---TLTGHTG-AVRSVAFSPDGKTLASGSDDGTVRLWDLAT- 361

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*....
gi 1622827025  779 ldpphdekkFKQLLSWRAHSLEIIQVIYVEEKQVVITASIDGSVRLWHA 827
Cdd:COG2319    362 ---------GELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 205-459 4.86e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 100.49  E-value: 4.86e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827025  205 KLHNDWVMKIRYISALNCFGSCSLDSnhslvleSLK--RLEDNLPVREFsmpRGANTFCYCVKAN----VIVTGGDDKVI 278
Cdd:cd00200     48 KGHTGPVRDVAASADGTYLASGSSDK-------TIRlwDLETGECVRTL---TGHTSYVSSVAFSpdgrILSSSSRDKTI 117

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827025  279 RLWHpNISTKPVGKLVGHMFSITEIVTNEKDQHIVSLSSAKVFRVWDIQTLSLLQVFHDSQGgpgdmQIYSMIYDANHGM 358
Cdd:cd00200    118 KVWD-VETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTG-----EVNSVAFSPDGEK 191

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827025  359 LITGSSVMDMYPLTRMIQDTKQVPHTHEREINVMLY--NKYLhqvLTICSE-SIIRVWELETGLQVYQIldpHGFNIEVT 435
Cdd:cd00200    192 LLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFspDGYL---LASGSEdGTIRVWDLRTGECVQTL---SGHTNSVT 265

                          250       260
                   ....*....|....*....|....
gi 1622827025  436 SAAVDESGFFFATGAYNGTVRIWD 459
Cdd:cd00200    266 SLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
269-475 1.78e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.90  E-value: 1.78e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827025  269 IVTGGDDKVIRLWHPNiSTKPVGKLVGHMFSITEIVTNEKDQHIVSLSSAKVFRVWDIQTLSLLQVFHDSQGGpgdmqIY 348
Cdd:COG2319    177 LASGSDDGTVRLWDLA-TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGS-----VR 250

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827025  349 SMIYDANHGMLITGSSvmdmyplTRMIQ----DTKQVPHT---HEREINVMLYNKYLHQVLTICSESIIRVWELETGlQV 421
Cdd:COG2319    251 SVAFSPDGRLLASGSA-------DGTVRlwdlATGELLRTltgHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATG-KL 322

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1622827025  422 YQILDPHgfNIEVTSAAVDESGFFFATGAYNGTVRIWDFGSGQEMKVLLEGKDW 475
Cdd:COG2319    323 LRTLTGH--TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGA 374
WD40 COG2319
WD40 repeat [General function prediction only];
309-827 7.43e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 62.24  E-value: 7.43e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827025  309 DQHIVSLSSAKVFRVWDIQTLSLLQVFHDSQGgpgdmQIYSMIYDANHGMLITGSSVMDMYPLTRMIQDTKQVPHTHERE 388
Cdd:COG2319      6 GAALAAASADLALALLAAALGALLLLLLGLAA-----AVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827025  389 INVMLYNKYLHQVLTICSESIIRVWELETGLQVYQILDPHGfniEVTSAAVDESGFFFATGAYNGTVRIWDFGSGQEMKV 468
Cdd:COG2319     81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTG---AVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRT 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827025  469 LLEGKDWkeeehcLQRLVFLKaqeKHQHLVLAlERNGTIKmiqgkeddiylmvIWELPD--VVPFLQDGKHAVH-LRVSt 545
Cdd:COG2319    158 LTGHSGA------VTSVAFSP---DGKLLASG-SDDGTVR-------------LWDLATgkLLRTLTGHTGAVRsVAFS- 213

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827025  546 rdrnmaipfPDvelivernasqpsnnpamdslrvncidllqveGyNLIAAGTLNGMIILWNFVTSTVKKVcrledcfpvn 625
Cdd:COG2319    214 ---------PD--------------------------------G-KLLASGSADGTVRLWDLATGKLLRT---------- 241

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827025  626 pdLHPKHFKINDILFlfrtpecarrssqdsicsssqceSSKGPQ--SskGSkqsiHDSEVKgeQTDVTVGEQQPVDKKHP 703
Cdd:COG2319    242 --LTGHSGSVRSVAF-----------------------SPDGRLlaS--GS----ADGTVR--LWDLATGELLRTLTGHS 288

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827025  704 GSAN----LPEAQppILVTAHEDGHLRLWTLE-GRLLKdmlPFTKHSAiSLTSLYTDSCTRILLAGNVEGHVILCNISSf 778
Cdd:COG2319    289 GGVNsvafSPDGK--LLASGSDDGTVRLWDLAtGKLLR---TLTGHTG-AVRSVAFSPDGKTLASGSDDGTVRLWDLAT- 361

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*....
gi 1622827025  779 ldpphdekkFKQLLSWRAHSLEIIQVIYVEEKQVVITASIDGSVRLWHA 827
Cdd:COG2319    362 ---------GELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 433-459 2.08e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 2.08e-03
                            10        20
                    ....*....|....*....|....*..
gi 1622827025   433 EVTSAAVDESGFFFATGAYNGTVRIWD 459
Cdd:smart00320   14 PVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 711-831 2.70e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.78  E-value: 2.70e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827025  711 AQPPILVTAHEDGHLRLWTLEGRLLKDMLpfTKHSAISLTSLYTDSCTRILLAGNveGHVILCnissfldppHDEKKFKQ 790
Cdd:cd00200     19 PDGKLLATGSGDGTIKVWDLETGELLRTL--KGHTGPVRDVAASADGTYLASGSS--DKTIRL---------WDLETGEC 85

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1622827025  791 LLSWRAHSLEIIQVIYVEEKQVVITASIDGSVRLW--------HALNGH 831
Cdd:cd00200     86 VRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWdvetgkclTTLRGH 134
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 205-459 4.86e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 100.49  E-value: 4.86e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827025  205 KLHNDWVMKIRYISALNCFGSCSLDSnhslvleSLK--RLEDNLPVREFsmpRGANTFCYCVKAN----VIVTGGDDKVI 278
Cdd:cd00200     48 KGHTGPVRDVAASADGTYLASGSSDK-------TIRlwDLETGECVRTL---TGHTSYVSSVAFSpdgrILSSSSRDKTI 117

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827025  279 RLWHpNISTKPVGKLVGHMFSITEIVTNEKDQHIVSLSSAKVFRVWDIQTLSLLQVFHDSQGgpgdmQIYSMIYDANHGM 358
Cdd:cd00200    118 KVWD-VETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTG-----EVNSVAFSPDGEK 191

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827025  359 LITGSSVMDMYPLTRMIQDTKQVPHTHEREINVMLY--NKYLhqvLTICSE-SIIRVWELETGLQVYQIldpHGFNIEVT 435
Cdd:cd00200    192 LLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFspDGYL---LASGSEdGTIRVWDLRTGECVQTL---SGHTNSVT 265

                          250       260
                   ....*....|....*....|....
gi 1622827025  436 SAAVDESGFFFATGAYNGTVRIWD 459
Cdd:cd00200    266 SLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
269-475 1.78e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.90  E-value: 1.78e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827025  269 IVTGGDDKVIRLWHPNiSTKPVGKLVGHMFSITEIVTNEKDQHIVSLSSAKVFRVWDIQTLSLLQVFHDSQGGpgdmqIY 348
Cdd:COG2319    177 LASGSDDGTVRLWDLA-TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGS-----VR 250

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827025  349 SMIYDANHGMLITGSSvmdmyplTRMIQ----DTKQVPHT---HEREINVMLYNKYLHQVLTICSESIIRVWELETGlQV 421
Cdd:COG2319    251 SVAFSPDGRLLASGSA-------DGTVRlwdlATGELLRTltgHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATG-KL 322

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1622827025  422 YQILDPHgfNIEVTSAAVDESGFFFATGAYNGTVRIWDFGSGQEMKVLLEGKDW 475
Cdd:COG2319    323 LRTLTGH--TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGA 374
WD40 COG2319
WD40 repeat [General function prediction only];
269-475 3.19e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.13  E-value: 3.19e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827025  269 IVTGGDDKVIRLWHPNiSTKPVGKLVGHMFSITEIVTNEKDQHIVSLSSAKVFRVWDIQTLSLLQVFHDSQGGpgdmqIY 348
Cdd:COG2319    135 LASGSADGTVRLWDLA-TGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA-----VR 208

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827025  349 SMIYDANHGMLITGSSvmDmypltRMIQ----DTKQVPHT---HEREINVMLYNKYLHQVLTICSESIIRVWELETGLQV 421
Cdd:COG2319    209 SVAFSPDGKLLASGSA--D-----GTVRlwdlATGKLLRTltgHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELL 281

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1622827025  422 yQILDPHGFniEVTSAAVDESGFFFATGAYNGTVRIWDFGSGQEMKVLLEGKDW 475
Cdd:COG2319    282 -RTLTGHSG--GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA 332
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 255-469 5.13e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 88.55  E-value: 5.13e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827025  255 RGANTFCYCVKA----NVIVTGGDDKVIRLWhpNIST-KPVGKLVGHMFSITEIVTNEKDQHIVSLSSAKVFRVWDIQTL 329
Cdd:cd00200      6 KGHTGGVTCVAFspdgKLLATGSGDGTIKVW--DLETgELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETG 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827025  330 SLLQVFHDSQGGpgdmqIYSMIYDANHGMLITGSSvmDMyplTRMIQDT-----KQVPHTHEREINVMLYNKYLHQVLTI 404
Cdd:cd00200     84 ECVRTLTGHTSY-----VSSVAFSPDGRILSSSSR--DK---TIKVWDVetgkcLTTLRGHTDWVNSVAFSPDGTFVASS 153

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622827025  405 CSESIIRVWELETGLQVYQIldpHGFNIEVTSAAVDESGFFFATGAYNGTVRIWDFGSGQEMKVL 469
Cdd:cd00200    154 SQDGTIKLWDLRTGKCVATL---TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTL 215
WD40 COG2319
WD40 repeat [General function prediction only];
267-459 4.47e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 87.66  E-value: 4.47e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827025  267 NVIVTGGDDKVIRLWHPNiSTKPVGKLVGHMFSITEIVTNEKDQHIVSLSSAKVFRVWDIQTLSLLQVFHDSQGGpgdmq 346
Cdd:COG2319    217 KLLASGSADGTVRLWDLA-TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGG----- 290

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827025  347 IYSMIYDANHGMLITGSS-----VMDMypltrmiqDTKQVPHT---HEREINVMLYNKYLHQVLTICSESIIRVWELETG 418
Cdd:COG2319    291 VNSVAFSPDGKLLASGSDdgtvrLWDL--------ATGKLLRTltgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATG 362

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 1622827025  419 LQVYQILDPHGfniEVTSAAVDESGFFFATGAYNGTVRIWD 459
Cdd:COG2319    363 ELLRTLTGHTG---AVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
268-475 4.66e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 81.50  E-value: 4.66e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827025  268 VIVTGGDDKVIRLWHPNiSTKPVGKLVGHMFSITEIVTNEKDQHIVSLSSAKVFRVWDIQTLSLLQVFHDSQGGpgdmqI 347
Cdd:COG2319     92 LLASASADGTVRLWDLA-TGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGA-----V 165

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827025  348 YSMIYDANHGMLITGSSvmdmyplTRMIQ----DTKQVPHT---HEREINVMLYN---KYLhqvLTICSESIIRVWELET 417
Cdd:COG2319    166 TSVAFSPDGKLLASGSD-------DGTVRlwdlATGKLLRTltgHTGAVRSVAFSpdgKLL---ASGSADGTVRLWDLAT 235

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622827025  418 GLQVyQILDPHGFniEVTSAAVDESGFFFATGAYNGTVRIWDFGSGQEMKVLLEGKDW 475
Cdd:COG2319    236 GKLL-RTLTGHSG--SVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGG 290
WD40 COG2319
WD40 repeat [General function prediction only];
266-469 2.11e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 70.33  E-value: 2.11e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827025  266 ANVIVTGGDDKVIRLWhPNISTKPVGKLVGHMFSITEIVTNEKDQHIVSLSSAKVFRVWDIQTLSLLQVFHDSQGGpgdm 345
Cdd:COG2319     48 GARLAAGAGDLTLLLL-DAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGA---- 122

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827025  346 qIYSMIYDANHGMLITGSS-----VMDMypltrmiqDTKQVPHT---HEREINVMLYN---KYLhqvLTICSESIIRVWE 414
Cdd:COG2319    123 -VRSVAFSPDGKTLASGSAdgtvrLWDL--------ATGKLLRTltgHSGAVTSVAFSpdgKLL---ASGSDDGTVRLWD 190

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1622827025  415 LETGlQVYQILDPHGFniEVTSAAVDESGFFFATGAYNGTVRIWDFGSGQEMKVL 469
Cdd:COG2319    191 LATG-KLLRTLTGHTG--AVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTL 242
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 289-469 2.61e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 62.74  E-value: 2.61e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827025  289 PVGKLVGHMFSITEIVTNEKDQHIVSLSSAKVFRVWDIQTLSLLQVFHDSQGGpgdmqIYSMIYDANHGMLITGSsvMDm 368
Cdd:cd00200      1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGP-----VRDVAASADGTYLASGS--SD- 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827025  369 ypltRMIQ----DTKQVPHT---HEREINVMLYNKYLHQVLTICSESIIRVWELETGLQVYQILDPHGFnieVTSAAVDE 441
Cdd:cd00200     73 ----KTIRlwdlETGECVRTltgHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDW---VNSVAFSP 145

                          170       180
                   ....*....|....*....|....*...
gi 1622827025  442 SGFFFATGAYNGTVRIWDFGSGQEMKVL 469
Cdd:cd00200    146 DGTFVASSSQDGTIKLWDLRTGKCVATL 173
WD40 COG2319
WD40 repeat [General function prediction only];
309-827 7.43e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 62.24  E-value: 7.43e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827025  309 DQHIVSLSSAKVFRVWDIQTLSLLQVFHDSQGgpgdmQIYSMIYDANHGMLITGSSVMDMYPLTRMIQDTKQVPHTHERE 388
Cdd:COG2319      6 GAALAAASADLALALLAAALGALLLLLLGLAA-----AVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827025  389 INVMLYNKYLHQVLTICSESIIRVWELETGLQVYQILDPHGfniEVTSAAVDESGFFFATGAYNGTVRIWDFGSGQEMKV 468
Cdd:COG2319     81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTG---AVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRT 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827025  469 LLEGKDWkeeehcLQRLVFLKaqeKHQHLVLAlERNGTIKmiqgkeddiylmvIWELPD--VVPFLQDGKHAVH-LRVSt 545
Cdd:COG2319    158 LTGHSGA------VTSVAFSP---DGKLLASG-SDDGTVR-------------LWDLATgkLLRTLTGHTGAVRsVAFS- 213

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827025  546 rdrnmaipfPDvelivernasqpsnnpamdslrvncidllqveGyNLIAAGTLNGMIILWNFVTSTVKKVcrledcfpvn 625
Cdd:COG2319    214 ---------PD--------------------------------G-KLLASGSADGTVRLWDLATGKLLRT---------- 241

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827025  626 pdLHPKHFKINDILFlfrtpecarrssqdsicsssqceSSKGPQ--SskGSkqsiHDSEVKgeQTDVTVGEQQPVDKKHP 703
Cdd:COG2319    242 --LTGHSGSVRSVAF-----------------------SPDGRLlaS--GS----ADGTVR--LWDLATGELLRTLTGHS 288

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827025  704 GSAN----LPEAQppILVTAHEDGHLRLWTLE-GRLLKdmlPFTKHSAiSLTSLYTDSCTRILLAGNVEGHVILCNISSf 778
Cdd:COG2319    289 GGVNsvafSPDGK--LLASGSDDGTVRLWDLAtGKLLR---TLTGHTG-AVRSVAFSPDGKTLASGSDDGTVRLWDLAT- 361

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*....
gi 1622827025  779 ldpphdekkFKQLLSWRAHSLEIIQVIYVEEKQVVITASIDGSVRLWHA 827
Cdd:COG2319    362 ---------GELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 347-475 1.15e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 57.73  E-value: 1.15e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827025  347 IYSMIYDANHGMLITGSSvmD----MYPLTRMIQDTKQVPHTHEreINVMLYNKYLHQVLTICSESIIRVWELETGLQVY 422
Cdd:cd00200     12 VTCVAFSPDGKLLATGSG--DgtikVWDLETGELLRTLKGHTGP--VRDVAASADGTYLASGSSDKTIRLWDLETGECVR 87

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1622827025  423 QIldpHGFNIEVTSAAVDESGFFFATGAYNGTVRIWDFGSGQEMKVLLEGKDW 475
Cdd:cd00200     88 TL---TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDW 137
WD40 COG2319
WD40 repeat [General function prediction only];
269-328 1.88e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 48.37  E-value: 1.88e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827025  269 IVTGGDDKVIRLWHPNiSTKPVGKLVGHMFSITEIVTNEKDQHIVSLSSAKVFRVWDIQT 328
Cdd:COG2319    345 LASGSDDGTVRLWDLA-TGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
715-830 1.44e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 45.29  E-value: 1.44e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827025  715 ILVTAHEDGHLRLWTLE-GRLLKdmlPFTKHS------AISltslyTDSctRILLAGNVEGHVILCNISSFldpphdekk 787
Cdd:COG2319    134 TLASGSADGTVRLWDLAtGKLLR---TLTGHSgavtsvAFS-----PDG--KLLASGSDDGTVRLWDLATG--------- 194

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1622827025  788 fKQLLSWRAHSLEIIQVIYVEEKQVVITASIDGSVRLWHALNG 830
Cdd:COG2319    195 -KLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG 236
WD40 COG2319
WD40 repeat [General function prediction only];
687-830 5.28e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 43.75  E-value: 5.28e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827025  687 QTDVTVGEQQPVDKKHPGSANLPEAQPP--ILVTAHEDGHLRLWTLEGRLLKdmLPFTKHSAiSLTSLYTDSCTRILLAG 764
Cdd:COG2319     62 LLDAAAGALLATLLGHTAAVLSVAFSPDgrLLASASADGTVRLWDLATGLLL--RTLTGHTG-AVRSVAFSPDGKTLASG 138

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622827025  765 NVEGHVILCNISSFldpphdekkfKQLLSWRAHSLEIIQVIYVEEKQVVITASIDGSVRLWHALNG 830
Cdd:COG2319    139 SADGTVRLWDLATG----------KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG 194
WD40 COG2319
WD40 repeat [General function prediction only];
715-830 1.14e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.59  E-value: 1.14e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827025  715 ILVTAHEDGHLRLWTLE-GRLLKdmlPFTKHSAiSLTSLYTDSCTRILLAGNVEGHVILCNISSFldpphdekkfKQLLS 793
Cdd:COG2319    176 LLASGSDDGTVRLWDLAtGKLLR---TLTGHTG-AVRSVAFSPDGKLLASGSADGTVRLWDLATG----------KLLRT 241

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1622827025  794 WRAHSLEIIQVIYVEEKQVVITASIDGSVRLWHALNG 830
Cdd:COG2319    242 LTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG 278
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 433-459 2.08e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 2.08e-03
                            10        20
                    ....*....|....*....|....*..
gi 1622827025   433 EVTSAAVDESGFFFATGAYNGTVRIWD 459
Cdd:smart00320   14 PVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 711-831 2.70e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.78  E-value: 2.70e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622827025  711 AQPPILVTAHEDGHLRLWTLEGRLLKDMLpfTKHSAISLTSLYTDSCTRILLAGNveGHVILCnissfldppHDEKKFKQ 790
Cdd:cd00200     19 PDGKLLATGSGDGTIKVWDLETGELLRTL--KGHTGPVRDVAASADGTYLASGSS--DKTIRL---------WDLETGEC 85

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1622827025  791 LLSWRAHSLEIIQVIYVEEKQVVITASIDGSVRLW--------HALNGH 831
Cdd:cd00200     86 VRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWdvetgkclTTLRGH 134
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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