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Conserved domains on  [gi|1622914245|ref|XP_014982152|]
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contactin-associated protein-like 4 isoform X2 [Macaca mulatta]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 512-630 2.25e-30

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 116.37  E-value: 2.25e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914245 512 FKTTASSGVFLEN-LGITDFIRIELRSPTVVtFSFDVGNGPFEISVqSPTHFNDNQWHHVRIERNMKEASLQVDQLTRKT 590
Cdd:pfam02210   1 FRTRQPNGLLLYAgGGGSDFLALELVNGRLV-LRYDLGSGPESLLS-SGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1622914245 591 QPAPADGHvLLQLNSQLFVGG--------TATRQRGFLGCIRSLQLNG 630
Cdd:pfam02210  79 SLPPGESL-LLNLNGPLYLGGlppllllpALPVRAGFVGCIRDVRVNG 125
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 89-215 4.11e-27

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 107.12  E-value: 4.11e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914245  89 FRTWNKAGLLLFSElQLVSGSILLFLSDGKLKLNLYQPGKLPSDITAGVGLNDGQWHSVSLSAKKNHLSVAVDGQ-LASA 167
Cdd:pfam02210   1 FRTRQPNGLLLYAG-GGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQtVVSS 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1622914245 168 APPLGPEQIYSDGTYYFGGCPDKSfGSKCKSPLGGFQGCMRLISIGGR 215
Cdd:pfam02210  80 LPPGESLLLNLNGPLYLGGLPPLL-LLPALPVRAGFVGCIRDVRVNGE 126
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 737-867 1.02e-18

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 83.24  E-value: 1.02e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914245 737 FRTTRTPSLLLFVSSFYKEYLSVIIaKNGSLQIRYKLNRYQEPDVVNFdfKNMADGQLHHVVINREEGVVFIEIDDNTRR 816
Cdd:pfam02210   1 FRTRQPNGLLLYAGGGGSDFLALEL-VNGRLVLRYDLGSGPESLLSSG--KNLNDGQWHSVRVERNGNTLTLSVDGQTVV 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1622914245 817 QVHLSSGTE-FSAVKSLVLGRileHSDVDQETALAGAQGFTGCLSAVQLSHV 867
Cdd:pfam02210  78 SSLPPGESLlLNLNGPLYLGG---LPPLLLLPALPVRAGFVGCIRDVRVNGE 126
GGGWT_bact super family cl49103
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 284-325 4.88e-08

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


The actual alignment was detected with superfamily member NF040941:

Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 49.87  E-value: 4.88e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1622914245 284 SCEAYKHRGNT--SGFYYIDSDGSGPLEPFLLYCNMteTT----WTII 325
Cdd:NF040941    1 SCWEILQAGPSapSGVYWIDPDGMGGLAPFQVYCDM--TTdgggWTLV 46
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 244-275 2.21e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.29  E-value: 2.21e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1622914245 244 CSPNYCEHGGECSQSWSAFHCNCTnTGYRGAT 275
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTGKR 31
COLFI super family cl02436
Fibrillar collagen C-terminal domain; Found at C-termini of fibrillar collagens: Ephydatia ...
 295-378 5.40e-04

Fibrillar collagen C-terminal domain; Found at C-termini of fibrillar collagens: Ephydatia muelleri procollagen EMF1 alpha, vertebrate collagens alpha(1)III, alpha(1)II, alpha(2)V etc.


The actual alignment was detected with superfamily member smart00038:

Pssm-ID: 470578  Cd Length: 232  Bit Score: 42.84  E-value: 5.40e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914245  295 SGFYYIDSDGSGPLEPFLLYCNMtETTWTIIQHNGSDLTRVRNTNPENPYAGF---------FEYVAS----MEQLQATI 361
Cdd:smart00038  44 SGEYWVDPNQGCIRDAIKVFCNF-ETGETCVSPSPSSIPRKTWYSGKSKHVWFgetmnggfkFSYGDSegppVGVVQLTF 122

                           90
                   ....*....|....*....
gi 1622914245  362 NR--AEHCEQEFTYYCKKS 378
Cdd:smart00038 123 LRllSTEAHQNITYHCKNS 141
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 653-687 3.38e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 3.38e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1622914245 653 CSSYGkLCRNGGKCRERPIGFFCDCTfSAYTGPFC 687
Cdd:cd00054     5 CASGN-PCQNGGTCVNTVGSYRCSCP-PGYTGRNC 37
 
Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 512-630 2.25e-30

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 116.37  E-value: 2.25e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914245 512 FKTTASSGVFLEN-LGITDFIRIELRSPTVVtFSFDVGNGPFEISVqSPTHFNDNQWHHVRIERNMKEASLQVDQLTRKT 590
Cdd:pfam02210   1 FRTRQPNGLLLYAgGGGSDFLALELVNGRLV-LRYDLGSGPESLLS-SGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1622914245 591 QPAPADGHvLLQLNSQLFVGG--------TATRQRGFLGCIRSLQLNG 630
Cdd:pfam02210  79 SLPPGESL-LLNLNGPLYLGGlppllllpALPVRAGFVGCIRDVRVNG 125
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 485-629 3.56e-30

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 116.75  E-value: 3.56e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914245 485 SASFDTEaSYLHFPTFHGEL-SADVSFFFKTTASSGV--FLENLGITDFIRIELRSPTVVtfsFDVGNGPFEISVQSPTH 561
Cdd:cd00110     1 GVSFSGS-SYVRLPTLPAPRtRLSISFSFRTTSPNGLllYAGSQNGGDFLALELEDGRLV---LRYDLGSGSLVLSSKTP 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622914245 562 FNDNQWHHVRIERNMKEASLQVDQLTRKTQPAPaDGHVLLQLNSQLFVGGT--------ATRQRGFLGCIRSLQLN 629
Cdd:cd00110    77 LNDGQWHSVSVERNGRSVTLSVDGERVVESGSP-GGSALLNLDGPLYLGGLpedlkspgLPVSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
507-631 2.93e-29

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 113.59  E-value: 2.93e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914245  507 DVSFFFKTTASSGV--FLENLGITDFIRIELRSPTVVtFSFDVGNGPFEISVQsPTHFNDNQWHHVRIERNMKEASLQVD 584
Cdd:smart00282   1 SISFSFRTTSPNGLllYAGSKGGGDYLALELRDGRLV-LRYDLGSGPARLTSD-PTPLNDGQWHRVAVERNGRSVTLSVD 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1622914245  585 QLTRKTQPAPAdGHVLLQLNSQLFVGGT--------ATRQRGFLGCIRSLQLNGM 631
Cdd:smart00282  79 GGNRVSGESPG-GLTILNLDGPLYLGGLpedlklppLPVTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 89-215 4.11e-27

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 107.12  E-value: 4.11e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914245  89 FRTWNKAGLLLFSElQLVSGSILLFLSDGKLKLNLYQPGKLPSDITAGVGLNDGQWHSVSLSAKKNHLSVAVDGQ-LASA 167
Cdd:pfam02210   1 FRTRQPNGLLLYAG-GGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQtVVSS 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1622914245 168 APPLGPEQIYSDGTYYFGGCPDKSfGSKCKSPLGGFQGCMRLISIGGR 215
Cdd:pfam02210  80 LPPGESLLLNLNGPLYLGGLPPLL-LLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 62-212 1.41e-26

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 106.35  E-value: 1.41e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914245  62 PVTFlSSRSYLALPDFSGEE-EVSATFQFRTWNKAGLLLFSELQLVSGSILLFLSDGKLKLNlYQPGKLPSDITAGVGLN 140
Cdd:cd00110     1 GVSF-SGSSYVRLPTLPAPRtRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLR-YDLGSGSLVLSSKTPLN 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622914245 141 DGQWHSVSLSAKKNHLSVAVDG-QLASAAPPLGPEQIYSDGTYYFGGCPDKSfGSKCKSPLGGFQGCMRLISI 212
Cdd:cd00110    79 DGQWHSVSVERNGRSVTLSVDGeRVVESGSPGGSALLNLDGPLYLGGLPEDL-KSPGLPVSPGFVGCIRDLKV 150
LamG smart00282
Laminin G domain;
84-215 4.09e-22

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 92.79  E-value: 4.09e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914245   84 SATFQFRTWNKAGLLLFSELQLVSGSILLFLSDGKLKLnLYQPGKLPSDITAGVG-LNDGQWHSVSLSAKKNHLSVAVDG 162
Cdd:smart00282   1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVL-RYDLGSGPARLTSDPTpLNDGQWHRVAVERNGRSVTLSVDG 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1622914245  163 QLASAAP-PLGPEQIYSDGTYYFGGCPDkSFGSKCKSPLGGFQGCMRLISIGGR 215
Cdd:smart00282  80 GNRVSGEsPGGLTILNLDGPLYLGGLPE-DLKLPPLPVTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 737-867 1.02e-18

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 83.24  E-value: 1.02e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914245 737 FRTTRTPSLLLFVSSFYKEYLSVIIaKNGSLQIRYKLNRYQEPDVVNFdfKNMADGQLHHVVINREEGVVFIEIDDNTRR 816
Cdd:pfam02210   1 FRTRQPNGLLLYAGGGGSDFLALEL-VNGRLVLRYDLGSGPESLLSSG--KNLNDGQWHSVRVERNGNTLTLSVDGQTVV 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1622914245 817 QVHLSSGTE-FSAVKSLVLGRileHSDVDQETALAGAQGFTGCLSAVQLSHV 867
Cdd:pfam02210  78 SSLPPGESLlLNLNGPLYLGG---LPPLLLLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 733-864 1.15e-13

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 69.37  E-value: 1.15e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914245 733 IKFSFRTTRTPSLLLFVSSF-YKEYLSVIIaKNGSLQIRYKLN----RYQEPDVVNfdfknmaDGQLHHVVINREEGVVF 807
Cdd:cd00110    24 ISFSFRTTSPNGLLLYAGSQnGGDFLALEL-EDGRLVLRYDLGsgslVLSSKTPLN-------DGQWHSVSVERNGRSVT 95

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622914245 808 IEIDDNTRRQVHLSSGTEF-SAVKSLVLGRILEHSDVdqeTALAGAQGFTGCLSAVQL 864
Cdd:cd00110    96 LSVDGERVVESGSPGGSALlNLDGPLYLGGLPEDLKS---PGLPVSPGFVGCIRDLKV 150
LamG smart00282
Laminin G domain;
733-867 2.07e-13

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 68.13  E-value: 2.07e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914245  733 IKFSFRTTRTPSLLLFVSSFYK-EYLSVIIaKNGSLQIRYKLNryQEPDVVNFDFKNMADGQLHHVVINREEGVVFIEID 811
Cdd:smart00282   2 ISFSFRTTSPNGLLLYAGSKGGgDYLALEL-RDGRLVLRYDLG--SGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVD 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622914245  812 DNTRRQVHLSSGTEFSAVKS-LVLGRILEHSDVDQETAlagAQGFTGCLSAVQLSHV 867
Cdd:smart00282  79 GGNRVSGESPGGLTILNLDGpLYLGGLPEDLKLPPLPV---TPGFRGCIRNLKVNGK 132
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 284-325 4.88e-08

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 49.87  E-value: 4.88e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1622914245 284 SCEAYKHRGNT--SGFYYIDSDGSGPLEPFLLYCNMteTT----WTII 325
Cdd:NF040941    1 SCWEILQAGPSapSGVYWIDPDGMGGLAPFQVYCDM--TTdgggWTLV 46
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 244-275 2.21e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.29  E-value: 2.21e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1622914245 244 CSPNYCEHGGECSQSWSAFHCNCTnTGYRGAT 275
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTGKR 31
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
 286-334 2.24e-04

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 43.42  E-value: 2.24e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1622914245  286 EAYKHRGNTSGFYYIDSDGSGplEPFLLYCNMTETT--WTIIQH--NGS-DLTR 334
Cdd:smart00186   7 DVLQNGGKTSGLYTIYPDGSS--RPLKVYCDMETDGggWTVIQRrmDGSvDFYR 58
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 283-330 2.30e-04

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 43.77  E-value: 2.30e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1622914245 283 QSC-EAYKHRGNTSGFYYIDSDGSgpLEPFLLYCNMTETT--WTIIQH--NGS 330
Cdd:cd00087     4 RDCsEVLQRGGRTSGVYTIQPPGS--NEPFQVYCDMDTDGggWTVIQRrgDGS 54
COLFI smart00038
Fibrillar collagens C-terminal domain; Found at C-termini of fibrillar collagens: Ephydatia ...
 295-378 5.40e-04

Fibrillar collagens C-terminal domain; Found at C-termini of fibrillar collagens: Ephydatia muelleri procollagen EMF1alpha, vertebrate collagens alpha(1)III, alpha(1)II, alpha(2)V etc.


Pssm-ID: 197483  Cd Length: 232  Bit Score: 42.84  E-value: 5.40e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914245  295 SGFYYIDSDGSGPLEPFLLYCNMtETTWTIIQHNGSDLTRVRNTNPENPYAGF---------FEYVAS----MEQLQATI 361
Cdd:smart00038  44 SGEYWVDPNQGCIRDAIKVFCNF-ETGETCVSPSPSSIPRKTWYSGKSKHVWFgetmnggfkFSYGDSegppVGVVQLTF 122

                           90
                   ....*....|....*....
gi 1622914245  362 NR--AEHCEQEFTYYCKKS 378
Cdd:smart00038 123 LRllSTEAHQNITYHCKNS 141
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 235-276 3.22e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 3.22e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1622914245 235 IDSCGisdrcSPNYCEHGGECSQSWSAFHCNCTNtGYRGATC 276
Cdd:cd00054     2 IDECA-----SGNPCQNGGTCVNTVGSYRCSCPP-GYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 653-687 3.38e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 3.38e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1622914245 653 CSSYGkLCRNGGKCRERPIGFFCDCTfSAYTGPFC 687
Cdd:cd00054     5 CASGN-PCQNGGTCVNTVGSYRCSCP-PGYTGRNC 37
 
Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 512-630 2.25e-30

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 116.37  E-value: 2.25e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914245 512 FKTTASSGVFLEN-LGITDFIRIELRSPTVVtFSFDVGNGPFEISVqSPTHFNDNQWHHVRIERNMKEASLQVDQLTRKT 590
Cdd:pfam02210   1 FRTRQPNGLLLYAgGGGSDFLALELVNGRLV-LRYDLGSGPESLLS-SGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1622914245 591 QPAPADGHvLLQLNSQLFVGG--------TATRQRGFLGCIRSLQLNG 630
Cdd:pfam02210  79 SLPPGESL-LLNLNGPLYLGGlppllllpALPVRAGFVGCIRDVRVNG 125
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 485-629 3.56e-30

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 116.75  E-value: 3.56e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914245 485 SASFDTEaSYLHFPTFHGEL-SADVSFFFKTTASSGV--FLENLGITDFIRIELRSPTVVtfsFDVGNGPFEISVQSPTH 561
Cdd:cd00110     1 GVSFSGS-SYVRLPTLPAPRtRLSISFSFRTTSPNGLllYAGSQNGGDFLALELEDGRLV---LRYDLGSGSLVLSSKTP 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622914245 562 FNDNQWHHVRIERNMKEASLQVDQLTRKTQPAPaDGHVLLQLNSQLFVGGT--------ATRQRGFLGCIRSLQLN 629
Cdd:cd00110    77 LNDGQWHSVSVERNGRSVTLSVDGERVVESGSP-GGSALLNLDGPLYLGGLpedlkspgLPVSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
507-631 2.93e-29

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 113.59  E-value: 2.93e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914245  507 DVSFFFKTTASSGV--FLENLGITDFIRIELRSPTVVtFSFDVGNGPFEISVQsPTHFNDNQWHHVRIERNMKEASLQVD 584
Cdd:smart00282   1 SISFSFRTTSPNGLllYAGSKGGGDYLALELRDGRLV-LRYDLGSGPARLTSD-PTPLNDGQWHRVAVERNGRSVTLSVD 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1622914245  585 QLTRKTQPAPAdGHVLLQLNSQLFVGGT--------ATRQRGFLGCIRSLQLNGM 631
Cdd:smart00282  79 GGNRVSGESPG-GLTILNLDGPLYLGGLpedlklppLPVTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 89-215 4.11e-27

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 107.12  E-value: 4.11e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914245  89 FRTWNKAGLLLFSElQLVSGSILLFLSDGKLKLNLYQPGKLPSDITAGVGLNDGQWHSVSLSAKKNHLSVAVDGQ-LASA 167
Cdd:pfam02210   1 FRTRQPNGLLLYAG-GGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQtVVSS 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1622914245 168 APPLGPEQIYSDGTYYFGGCPDKSfGSKCKSPLGGFQGCMRLISIGGR 215
Cdd:pfam02210  80 LPPGESLLLNLNGPLYLGGLPPLL-LLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 62-212 1.41e-26

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 106.35  E-value: 1.41e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914245  62 PVTFlSSRSYLALPDFSGEE-EVSATFQFRTWNKAGLLLFSELQLVSGSILLFLSDGKLKLNlYQPGKLPSDITAGVGLN 140
Cdd:cd00110     1 GVSF-SGSSYVRLPTLPAPRtRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLR-YDLGSGSLVLSSKTPLN 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622914245 141 DGQWHSVSLSAKKNHLSVAVDG-QLASAAPPLGPEQIYSDGTYYFGGCPDKSfGSKCKSPLGGFQGCMRLISI 212
Cdd:cd00110    79 DGQWHSVSVERNGRSVTLSVDGeRVVESGSPGGSALLNLDGPLYLGGLPEDL-KSPGLPVSPGFVGCIRDLKV 150
LamG smart00282
Laminin G domain;
84-215 4.09e-22

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 92.79  E-value: 4.09e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914245   84 SATFQFRTWNKAGLLLFSELQLVSGSILLFLSDGKLKLnLYQPGKLPSDITAGVG-LNDGQWHSVSLSAKKNHLSVAVDG 162
Cdd:smart00282   1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVL-RYDLGSGPARLTSDPTpLNDGQWHRVAVERNGRSVTLSVDG 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1622914245  163 QLASAAP-PLGPEQIYSDGTYYFGGCPDkSFGSKCKSPLGGFQGCMRLISIGGR 215
Cdd:smart00282  80 GNRVSGEsPGGLTILNLDGPLYLGGLPE-DLKLPPLPVTPGFRGCIRNLKVNGK 132
Laminin_G_1 pfam00054
Laminin G domain;
512-634 1.50e-20

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 88.53  E-value: 1.50e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914245 512 FKTTASSGVFLENLGIT--DFIRIELRSPTVvTFSFDVGNGPfeISVQSPTHFNDNQWHHVRIERNMKEASLQVDQLTRK 589
Cdd:pfam00054   1 FRTTEPSGLLLYNGTQTerDFLALELRDGRL-EVSYDLGSGA--AVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARP 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622914245 590 T--QPAPADGHvlLQLNSQLFVGGT---------ATRQRGFLGCIRSLQLNGMTLD 634
Cdd:pfam00054  78 TgeSPLGATTD--LDVDGPLYVGGLpslgvkkrrLAISPSFDGCIRDVIVNGKPLD 131
Laminin_G_1 pfam00054
Laminin G domain;
89-218 2.46e-20

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 87.76  E-value: 2.46e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914245  89 FRTWNKAGLLLFSELQLVSGSILLFLSDGKLKLnLYQPGKLPSDITAGVGLNDGQWHSVSLSAKKNHLSVAVDGQLA-SA 167
Cdd:pfam00054   1 FRTTEPSGLLLYNGTQTERDFLALELRDGRLEV-SYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARpTG 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1622914245 168 APPLGPEQIYS-DGTYYFGGCPDKSFGSKCKSPLGGFQGCMRLISIGGRVVD 218
Cdd:pfam00054  80 ESPLGATTDLDvDGPLYVGGLPSLGVKKRRLAISPSFDGCIRDVIVNGKPLD 131
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 737-867 1.02e-18

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 83.24  E-value: 1.02e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914245 737 FRTTRTPSLLLFVSSFYKEYLSVIIaKNGSLQIRYKLNRYQEPDVVNFdfKNMADGQLHHVVINREEGVVFIEIDDNTRR 816
Cdd:pfam02210   1 FRTRQPNGLLLYAGGGGSDFLALEL-VNGRLVLRYDLGSGPESLLSSG--KNLNDGQWHSVRVERNGNTLTLSVDGQTVV 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1622914245 817 QVHLSSGTE-FSAVKSLVLGRileHSDVDQETALAGAQGFTGCLSAVQLSHV 867
Cdd:pfam02210  78 SSLPPGESLlLNLNGPLYLGG---LPPLLLLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 733-864 1.15e-13

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 69.37  E-value: 1.15e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914245 733 IKFSFRTTRTPSLLLFVSSF-YKEYLSVIIaKNGSLQIRYKLN----RYQEPDVVNfdfknmaDGQLHHVVINREEGVVF 807
Cdd:cd00110    24 ISFSFRTTSPNGLLLYAGSQnGGDFLALEL-EDGRLVLRYDLGsgslVLSSKTPLN-------DGQWHSVSVERNGRSVT 95

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622914245 808 IEIDDNTRRQVHLSSGTEF-SAVKSLVLGRILEHSDVdqeTALAGAQGFTGCLSAVQL 864
Cdd:cd00110    96 LSVDGERVVESGSPGGSALlNLDGPLYLGGLPEDLKS---PGLPVSPGFVGCIRDLKV 150
LamG smart00282
Laminin G domain;
733-867 2.07e-13

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 68.13  E-value: 2.07e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914245  733 IKFSFRTTRTPSLLLFVSSFYK-EYLSVIIaKNGSLQIRYKLNryQEPDVVNFDFKNMADGQLHHVVINREEGVVFIEID 811
Cdd:smart00282   2 ISFSFRTTSPNGLLLYAGSKGGgDYLALEL-RDGRLVLRYDLG--SGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVD 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622914245  812 DNTRRQVHLSSGTEFSAVKS-LVLGRILEHSDVDQETAlagAQGFTGCLSAVQLSHV 867
Cdd:smart00282  79 GGNRVSGESPGGLTILNLDGpLYLGGLPEDLKLPPLPV---TPGFRGCIRNLKVNGK 132
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 284-325 4.88e-08

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 49.87  E-value: 4.88e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1622914245 284 SCEAYKHRGNT--SGFYYIDSDGSGPLEPFLLYCNMteTT----WTII 325
Cdd:NF040941    1 SCWEILQAGPSapSGVYWIDPDGMGGLAPFQVYCDM--TTdgggWTLV 46
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 244-275 2.21e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.29  E-value: 2.21e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1622914245 244 CSPNYCEHGGECSQSWSAFHCNCTnTGYRGAT 275
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTGKR 31
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
 286-334 2.24e-04

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 43.42  E-value: 2.24e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1622914245  286 EAYKHRGNTSGFYYIDSDGSGplEPFLLYCNMTETT--WTIIQH--NGS-DLTR 334
Cdd:smart00186   7 DVLQNGGKTSGLYTIYPDGSS--RPLKVYCDMETDGggWTVIQRrmDGSvDFYR 58
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 283-330 2.30e-04

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 43.77  E-value: 2.30e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1622914245 283 QSC-EAYKHRGNTSGFYYIDSDGSgpLEPFLLYCNMTETT--WTIIQH--NGS 330
Cdd:cd00087     4 RDCsEVLQRGGRTSGVYTIQPPGS--NEPFQVYCDMDTDGggWTVIQRrgDGS 54
COLFI smart00038
Fibrillar collagens C-terminal domain; Found at C-termini of fibrillar collagens: Ephydatia ...
 295-378 5.40e-04

Fibrillar collagens C-terminal domain; Found at C-termini of fibrillar collagens: Ephydatia muelleri procollagen EMF1alpha, vertebrate collagens alpha(1)III, alpha(1)II, alpha(2)V etc.


Pssm-ID: 197483  Cd Length: 232  Bit Score: 42.84  E-value: 5.40e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914245  295 SGFYYIDSDGSGPLEPFLLYCNMtETTWTIIQHNGSDLTRVRNTNPENPYAGF---------FEYVAS----MEQLQATI 361
Cdd:smart00038  44 SGEYWVDPNQGCIRDAIKVFCNF-ETGETCVSPSPSSIPRKTWYSGKSKHVWFgetmnggfkFSYGDSegppVGVVQLTF 122

                           90
                   ....*....|....*....
gi 1622914245  362 NR--AEHCEQEFTYYCKKS 378
Cdd:smart00038 123 LRllSTEAHQNITYHCKNS 141
TSPN smart00210
Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of ...
 80-186 8.10e-04

Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of thrombospondin


Pssm-ID: 214560  Cd Length: 184  Bit Score: 41.57  E-value: 8.10e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914245   80 EEEVSATFQFRTWNKAGLLLFSELQLVSGSILLFLSDGKLKLNLY----QPGKLPSDITAGVGLNDGQWHSVSLSAKKNH 155
Cdd:smart00210  51 PEDFSLLTTFRQTPKSRGVLFAIYDAQNVRQFGLEVDGRANTLLLryqgVDGKQHTVSFRNLPLADGQWHKLALSVSGSS 130

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1622914245  156 LSVAVDGQLASAAP--PLGPEQIYSDGTYYFGG 186
Cdd:smart00210 131 ATLYVDCNEIDSRPldRPGQPPIDTDGIEVRGA 163
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 235-276 3.22e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 3.22e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1622914245 235 IDSCGisdrcSPNYCEHGGECSQSWSAFHCNCTNtGYRGATC 276
Cdd:cd00054     2 IDECA-----SGNPCQNGGTCVNTVGSYRCSCPP-GYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 653-687 3.38e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 3.38e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1622914245 653 CSSYGkLCRNGGKCRERPIGFFCDCTfSAYTGPFC 687
Cdd:cd00054     5 CASGN-PCQNGGTCVNTVGSYRCSCP-PGYTGRNC 37
Laminin_G_3 pfam13385
Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin ...
 107-186 3.57e-03

Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.


Pssm-ID: 463865 [Multi-domain]  Cd Length: 151  Bit Score: 38.90  E-value: 3.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914245 107 SGSILLFL-SDGKLKLNLYQPGKLPSDITAGVGLNDGQWHSVSLSAKKNHLSVAVDGQLASAAPPLGPEQIYSDGTYYFG 185
Cdd:pfam13385  43 GGGYSLGLdGDGRLRFAVNGGNGGWDTVTSGASVPLGQWTHVAVTYDGGTLRLYVNGVLVGSSTLTGGPPPGTGGPLYIG 122


                  .
gi 1622914245 186 G 186
Cdd:pfam13385 123 R 123
TSPN smart00210
Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of ...
 698-820 4.16e-03

Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of thrombospondin


Pssm-ID: 214560  Cd Length: 184  Bit Score: 39.26  E-value: 4.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914245  698 GSSVIYNFQENyllsKNSSSHAASFHgDMKLSREM-IKFSFRTTRTPSLLLF--VSSFYKEYLSVIIakNGSLQI---RY 771
Cdd:smart00210  25 PGSPAYRLGDP----ALVPQPTRDLF-PSGLPEDFsLLTTFRQTPKSRGVLFaiYDAQNVRQFGLEV--DGRANTlllRY 97

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1622914245  772 KLNRyQEPDVVNFDFKNMADGQLHHVVINREEGVVFIEIDDNTRRQVHL 820
Cdd:smart00210  98 QGVD-GKQHTVSFRNLPLADGQWHKLALSVSGSSATLYVDCNEIDSRPL 145
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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