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Conserved domains on  [gi|1622914629|ref|XP_014981969|]
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cadherin-3 isoform X1 [Macaca mulatta]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 219-324 1.72e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.01  E-value: 1.72e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914629 219 TFRGSVLEGVLPGTSVMQVTATDEDDAIhtyNGVVAYSIHSQEPKDphdlMFTIHRSTGTISVISSgLDREKVPEYTLTI 298
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGE---NGEVTYSIVSGNEDG----LFSIDPSTGEITTAKP-LDREEQSSYTLTV 72

                          90       100
                  ....*....|....*....|....*.
gi 1622914629 299 QATDMDGDGSTTTAVAVVEILDANDN 324
Cdd:cd11304    73 TATDGGGPPLSSTATVTITVLDVNDN 98
CA_like super family cl46864
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 113-211 2.02e-24

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


The actual alignment was detected with superfamily member cd00031:

Pssm-ID: 481204  Cd Length: 98  Bit Score: 98.19  E-value: 2.02e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914629 113 PISVPENGKGPfpQRLNQLKSNKDRDTKIFYSITGPGADSPPeGVFAVEKETGWLLLNKPLDREEIAKYELFGHAVSENG 192
Cdd:cd00031     3 DGSAVEGRSRG--SFRVSIPTDLIASSGEIIKISAAGKEALP-SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGA 79

                          90
                  ....*....|....*....
gi 1622914629 193 ASVEDPMNISVIVTDQNDH 211
Cdd:cd00031    80 NVPQTSSVFSIEVYDENDN 98
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 765-824 6.57e-24

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


:

Pssm-ID: 460041  Cd Length: 60  Bit Score: 95.30  E-value: 6.57e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914629 765 ANTDPTAPPYDSLLVFDYEGSGSDAASLSSLTSSTSDQDQDYDYLNEWGSRFKKLADMYG 824
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 333-436 3.72e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.30  E-value: 3.72e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914629 333 YESHVPENA-VGHEVQRLTVTDLDAPnsPAWRATYLIVGGDDGDHFTIathpESNQGILTTRKGLDFEAKNQHTLYVEVT 411
Cdd:cd11304     2 YEVSVPENApPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|....*
gi 1622914629 412 NEAPFVLklpTSTATIVVHVEDVNE 436
Cdd:cd11304    76 DGGGPPL---SSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 446-544 7.96e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.58  E-value: 7.96e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914629 446 VVEVQEGIPTGEAVCVYTAKDPDK-ENQKISYRILR-DPAGWLAMDPDSGQVTVAGTLDREderfvRNNIYEVMVLAVDN 523
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSgENGEVTYSIVSgNEDGLFSIDPSTGEITTAKPLDRE-----EQSSYTLTVTATDG 77

                          90       100
                  ....*....|....*....|.
gi 1622914629 524 GSPPTTGTGTLLLTLIDVNDH 544
Cdd:cd11304    78 GGPPLSSTATVTITVLDVNDN 98
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 219-324 1.72e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.01  E-value: 1.72e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914629 219 TFRGSVLEGVLPGTSVMQVTATDEDDAIhtyNGVVAYSIHSQEPKDphdlMFTIHRSTGTISVISSgLDREKVPEYTLTI 298
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGE---NGEVTYSIVSGNEDG----LFSIDPSTGEITTAKP-LDREEQSSYTLTV 72

                          90       100
                  ....*....|....*....|....*.
gi 1622914629 299 QATDMDGDGSTTTAVAVVEILDANDN 324
Cdd:cd11304    73 TATDGGGPPLSSTATVTITVLDVNDN 98
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 113-211 2.02e-24

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 98.19  E-value: 2.02e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914629 113 PISVPENGKGPfpQRLNQLKSNKDRDTKIFYSITGPGADSPPeGVFAVEKETGWLLLNKPLDREEIAKYELFGHAVSENG 192
Cdd:cd00031     3 DGSAVEGRSRG--SFRVSIPTDLIASSGEIIKISAAGKEALP-SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGA 79

                          90
                  ....*....|....*....
gi 1622914629 193 ASVEDPMNISVIVTDQNDH 211
Cdd:cd00031    80 NVPQTSSVFSIEVYDENDN 98
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 765-824 6.57e-24

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 95.30  E-value: 6.57e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914629 765 ANTDPTAPPYDSLLVFDYEGSGSDAASLSSLTSSTSDQDQDYDYLNEWGSRFKKLADMYG 824
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 333-436 3.72e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.30  E-value: 3.72e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914629 333 YESHVPENA-VGHEVQRLTVTDLDAPnsPAWRATYLIVGGDDGDHFTIathpESNQGILTTRKGLDFEAKNQHTLYVEVT 411
Cdd:cd11304     2 YEVSVPENApPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|....*
gi 1622914629 412 NEAPFVLklpTSTATIVVHVEDVNE 436
Cdd:cd11304    76 DGGGPPL---SSTATVTITVLDVND 97
Cadherin pfam00028
Cadherin domain;
220-319 9.11e-22

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 90.44  E-value: 9.11e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914629 220 FRGSVLEGVLPGTSVMQVTATDEDDaihTYNGVVAYSIHSQEPKDphdlMFTIHRSTGTISVISSgLDREKVPEYTLTIQ 299
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDL---GPNGRIFYSILGGGPGG----NFRIDPDTGDISTTKP-LDRESIGEYELTVE 72

                          90       100
                  ....*....|....*....|
gi 1622914629 300 ATDMDGDGSTTTAVAVVEIL 319
Cdd:pfam00028  73 ATDSGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 238-326 7.98e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.41  E-value: 7.98e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914629  238 TATDEDDAIhtyNGVVAYSIHSQEPKDphdlMFTIHRSTGTISVISSgLDREKVPEYTLTIQATDMDGDGSTTTAVAVVE 317
Cdd:smart00112   1 SATDADSGE---NGKVTYSILSGNDDG----LFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGGPPLSSTATVTIT 72


                   ....*....
gi 1622914629  318 ILDANDNAP 326
Cdd:smart00112  73 VLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
333-432 6.71e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 85.04  E-value: 6.71e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914629 333 YESHVPENA-VGHEVQRLTVTDLDAPnsPAWRATYLIVGGDDGDHFTIATHPesnqGILTTRKGLDFEAKNQHTLYVEVT 411
Cdd:pfam00028   1 YSASVPENApVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|.
gi 1622914629 412 NEAPFVLklpTSTATIVVHVE 432
Cdd:pfam00028  75 DSGGPPL---SSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 446-544 7.96e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.58  E-value: 7.96e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914629 446 VVEVQEGIPTGEAVCVYTAKDPDK-ENQKISYRILR-DPAGWLAMDPDSGQVTVAGTLDREderfvRNNIYEVMVLAVDN 523
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSgENGEVTYSIVSgNEDGLFSIDPSTGEITTAKPLDRE-----EQSSYTLTVTATDG 77

                          90       100
                  ....*....|....*....|.
gi 1622914629 524 GSPPTTGTGTLLLTLIDVNDH 544
Cdd:cd11304    78 GGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 350-438 7.37e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.15  E-value: 7.37e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914629  350 TVTDLDAPNSpaWRATYLIVGGDDGDHFTIathpESNQGILTTRKGLDFEAKNQHTLYVEVTNEAPFVLklpTSTATIVV 429
Cdd:smart00112   1 SATDADSGEN--GKVTYSILSGNDDGLFSI----DPETGEITTTKPLDREEQPEYTLTVEATDGGGPPL---SSTATVTI 71


                   ....*....
gi 1622914629  430 HVEDVNEAP 438
Cdd:smart00112  72 TVLDVNDNA 80
Cadherin pfam00028
Cadherin domain;
113-206 8.87e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.10  E-value: 8.87e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914629 113 PISVPENGK-GPFPQRLNQLKSNKDRDTKIFYSITGPGadspPEGVFAVEKETGWLLLNKPLDREEIAKYELFGHAVSEN 191
Cdd:pfam00028   2 SASVPENAPvGTEVLTVTATDPDLGPNGRIFYSILGGG----PGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....*
gi 1622914629 192 GASVEDPMNISVIVT 206
Cdd:pfam00028  78 GPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
446-527 3.43e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.56  E-value: 3.43e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914629 446 VVEVQEGIPTGEAVCVYTAKDPDKE-NQKISYRILRD-PAGWLAMDPDSGQVTVAGTLDREderfvRNNIYEVMVLAVDN 523
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDLGpNGRIFYSILGGgPGGNFRIDPDTGDISTTKPLDRE-----SIGEYELTVEATDS 76


                  ....
gi 1622914629 524 GSPP 527
Cdd:pfam00028  77 GGPP 80
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 463-546 5.47e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 65.06  E-value: 5.47e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914629  463 TAKDPDK-ENQKISYRILR-DPAGWLAMDPDSGQVTVAGTLDREDerfvrNNIYEVMVLAVDNGSPPTTGTGTLLLTLID 540
Cdd:smart00112   1 SATDADSgENGKVTYSILSgNDDGLFSIDPETGEITTTKPLDREE-----QPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 1622914629  541 VNDHGP 546
Cdd:smart00112  76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 136-213 6.21e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 64.68  E-value: 6.21e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914629  136 DRDT----KIFYSITGPGADsppeGVFAVEKETGWLLLNKPLDREEIAKYELFGHAVSENGASVEDPMNISVIVTDQNDH 211
Cdd:smart00112   4 DADSgengKVTYSILSGNDD----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                   ..
gi 1622914629  212 KP 213
Cdd:smart00112  80 AP 81
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 219-324 1.72e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.01  E-value: 1.72e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914629 219 TFRGSVLEGVLPGTSVMQVTATDEDDAIhtyNGVVAYSIHSQEPKDphdlMFTIHRSTGTISVISSgLDREKVPEYTLTI 298
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGE---NGEVTYSIVSGNEDG----LFSIDPSTGEITTAKP-LDREEQSSYTLTV 72

                          90       100
                  ....*....|....*....|....*.
gi 1622914629 299 QATDMDGDGSTTTAVAVVEILDANDN 324
Cdd:cd11304    73 TATDGGGPPLSSTATVTITVLDVNDN 98
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 113-211 2.02e-24

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 98.19  E-value: 2.02e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914629 113 PISVPENGKGPfpQRLNQLKSNKDRDTKIFYSITGPGADSPPeGVFAVEKETGWLLLNKPLDREEIAKYELFGHAVSENG 192
Cdd:cd00031     3 DGSAVEGRSRG--SFRVSIPTDLIASSGEIIKISAAGKEALP-SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGA 79

                          90
                  ....*....|....*....
gi 1622914629 193 ASVEDPMNISVIVTDQNDH 211
Cdd:cd00031    80 NVPQTSSVFSIEVYDENDN 98
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 765-824 6.57e-24

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 95.30  E-value: 6.57e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914629 765 ANTDPTAPPYDSLLVFDYEGSGSDAASLSSLTSSTSDQDQDYDYLNEWGSRFKKLADMYG 824
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 333-436 3.72e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.30  E-value: 3.72e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914629 333 YESHVPENA-VGHEVQRLTVTDLDAPnsPAWRATYLIVGGDDGDHFTIathpESNQGILTTRKGLDFEAKNQHTLYVEVT 411
Cdd:cd11304     2 YEVSVPENApPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|....*
gi 1622914629 412 NEAPFVLklpTSTATIVVHVEDVNE 436
Cdd:cd11304    76 DGGGPPL---SSTATVTITVLDVND 97
Cadherin pfam00028
Cadherin domain;
220-319 9.11e-22

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 90.44  E-value: 9.11e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914629 220 FRGSVLEGVLPGTSVMQVTATDEDDaihTYNGVVAYSIHSQEPKDphdlMFTIHRSTGTISVISSgLDREKVPEYTLTIQ 299
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDL---GPNGRIFYSILGGGPGG----NFRIDPDTGDISTTKP-LDRESIGEYELTVE 72

                          90       100
                  ....*....|....*....|
gi 1622914629 300 ATDMDGDGSTTTAVAVVEIL 319
Cdd:pfam00028  73 ATDSGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 238-326 7.98e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.41  E-value: 7.98e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914629  238 TATDEDDAIhtyNGVVAYSIHSQEPKDphdlMFTIHRSTGTISVISSgLDREKVPEYTLTIQATDMDGDGSTTTAVAVVE 317
Cdd:smart00112   1 SATDADSGE---NGKVTYSILSGNDDG----LFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGGPPLSSTATVTIT 72


                   ....*....
gi 1622914629  318 ILDANDNAP 326
Cdd:smart00112  73 VLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
333-432 6.71e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 85.04  E-value: 6.71e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914629 333 YESHVPENA-VGHEVQRLTVTDLDAPnsPAWRATYLIVGGDDGDHFTIATHPesnqGILTTRKGLDFEAKNQHTLYVEVT 411
Cdd:pfam00028   1 YSASVPENApVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|.
gi 1622914629 412 NEAPFVLklpTSTATIVVHVE 432
Cdd:pfam00028  75 DSGGPPL---SSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 446-544 7.96e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.58  E-value: 7.96e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914629 446 VVEVQEGIPTGEAVCVYTAKDPDK-ENQKISYRILR-DPAGWLAMDPDSGQVTVAGTLDREderfvRNNIYEVMVLAVDN 523
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSgENGEVTYSIVSgNEDGLFSIDPSTGEITTAKPLDRE-----EQSSYTLTVTATDG 77

                          90       100
                  ....*....|....*....|.
gi 1622914629 524 GSPPTTGTGTLLLTLIDVNDH 544
Cdd:cd11304    78 GGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 350-438 7.37e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.15  E-value: 7.37e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914629  350 TVTDLDAPNSpaWRATYLIVGGDDGDHFTIathpESNQGILTTRKGLDFEAKNQHTLYVEVTNEAPFVLklpTSTATIVV 429
Cdd:smart00112   1 SATDADSGEN--GKVTYSILSGNDDGLFSI----DPETGEITTTKPLDREEQPEYTLTVEATDGGGPPL---SSTATVTI 71


                   ....*....
gi 1622914629  430 HVEDVNEAP 438
Cdd:smart00112  72 TVLDVNDNA 80
Cadherin pfam00028
Cadherin domain;
113-206 8.87e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.10  E-value: 8.87e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914629 113 PISVPENGK-GPFPQRLNQLKSNKDRDTKIFYSITGPGadspPEGVFAVEKETGWLLLNKPLDREEIAKYELFGHAVSEN 191
Cdd:pfam00028   2 SASVPENAPvGTEVLTVTATDPDLGPNGRIFYSILGGG----PGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....*
gi 1622914629 192 GASVEDPMNISVIVT 206
Cdd:pfam00028  78 GPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
446-527 3.43e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.56  E-value: 3.43e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914629 446 VVEVQEGIPTGEAVCVYTAKDPDKE-NQKISYRILRD-PAGWLAMDPDSGQVTVAGTLDREderfvRNNIYEVMVLAVDN 523
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDLGpNGRIFYSILGGgPGGNFRIDPDTGDISTTKPLDRE-----SIGEYELTVEATDS 76


                  ....
gi 1622914629 524 GSPP 527
Cdd:pfam00028  77 GGPP 80
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 463-546 5.47e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 65.06  E-value: 5.47e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914629  463 TAKDPDK-ENQKISYRILR-DPAGWLAMDPDSGQVTVAGTLDREDerfvrNNIYEVMVLAVDNGSPPTTGTGTLLLTLID 540
Cdd:smart00112   1 SATDADSgENGKVTYSILSgNDDGLFSIDPETGEITTTKPLDREE-----QPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 1622914629  541 VNDHGP 546
Cdd:smart00112  76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 136-213 6.21e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 64.68  E-value: 6.21e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914629  136 DRDT----KIFYSITGPGADsppeGVFAVEKETGWLLLNKPLDREEIAKYELFGHAVSENGASVEDPMNISVIVTDQNDH 211
Cdd:smart00112   4 DADSgengKVTYSILSGNDD----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                   ..
gi 1622914629  212 KP 213
Cdd:smart00112  80 AP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 114-211 7.42e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 65.03  E-value: 7.42e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914629 114 ISVPENGkgPFPQRLNQLKSnKDRDT----KIFYSITGPgadsPPEGVFAVEKETGWLLLNKPLDREEIAKYELFGHAVS 189
Cdd:cd11304     4 VSVPENA--PPGTVVLTVSA-TDPDSgengEVTYSIVSG----NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATD 76

                          90       100
                  ....*....|....*....|..
gi 1622914629 190 ENGASVEDPMNISVIVTDQNDH 211
Cdd:cd11304    77 GGGPPLSSTATVTITVLDVNDN 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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