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Conserved domains on  [gi|1622897978|ref|XP_014980562|]
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zinc finger protein 17 isoform X1 [Macaca mulatta]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

CATH:  3.30.160.60|1.10.287.1360
Gene Ontology:  GO:0003700|GO:0005515|GO:0008270|GO:0003677|GO:0006355|GO:0001217
PubMed:  22803940|8183940|2023909|8183939|10748030|27867147|28765213|11361095|30718982|10940247
SCOP:  4003583|4002243

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 7-48 8.90e-17

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 74.04  E-value: 8.90e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1622897978   7 CMVFEDVAIHFSQEEWGILNGVQRHLHSDVMLENFALLSSVG 48
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
244-656 2.31e-13

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.81  E-value: 2.31e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897978 244 RPYKCSECGKAFSLKYNVVQHQKIHTGERPYECS--ECGKAFLRKSHLLQHQRIHTRPRPYLCSecgKTFLTQAHLVGHQ 321
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNS---KSLPLSNSKASSS 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897978 322 KIH--TGERPYGCNECGKYFM----YSSALIRHQKVHTGERPFYCCECGKFFMDSCTLIIHQRVHTgekpyecNECGKFF 395
Cdd:COG5048   109 SLSssSSNSNDNNLLSSHSLPpssrDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN-------SLSKDPS 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897978 396 RYRSTLIRHQKVHTGEKPYECSECGKFFMDTStLIIHQRVHTGEKPYECSECGKFFRYCFTLNRHQRVHSGERPYECSEC 475
Cdd:COG5048   182 SNLSLLISSNVSTSIPSSSENSPLSSSYSIPS-SSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASES 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897978 476 GKFFV--DSCTLKSHQRVHTGER-----PFECSICGKSFRCRSTLDTHQR--IHTGE--RPYECSE--CGKFFRHNSNHI 542
Cdd:COG5048   261 PRSSLptASSQSSSPNESDSSSEkgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALK 340

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897978 543 RHRRNHFGERSFEC--TECGRVFSQNS----HLIRHQKVHTRERTYKC---SKCGKFFMDSSTLISHQRVHTGEKPYEC- 612
Cdd:COG5048   341 RHILLHTSISPAKEklLNSSSKFSPLLnnepPQSLQQYKDLKNDKKSEtlsNSCIRNFKRDSNLSLHIITHLSFRPYNCk 420

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 1622897978 613 -SECGKVFRYNSSLIKHRRIHTGERPYQCSECGRvFNQNSHLIQH 656
Cdd:COG5048   421 nPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 7-48 8.90e-17

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 74.04  E-value: 8.90e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1622897978   7 CMVFEDVAIHFSQEEWGILNGVQRHLHSDVMLENFALLSSVG 48
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
244-656 2.31e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.81  E-value: 2.31e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897978 244 RPYKCSECGKAFSLKYNVVQHQKIHTGERPYECS--ECGKAFLRKSHLLQHQRIHTRPRPYLCSecgKTFLTQAHLVGHQ 321
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNS---KSLPLSNSKASSS 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897978 322 KIH--TGERPYGCNECGKYFM----YSSALIRHQKVHTGERPFYCCECGKFFMDSCTLIIHQRVHTgekpyecNECGKFF 395
Cdd:COG5048   109 SLSssSSNSNDNNLLSSHSLPpssrDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN-------SLSKDPS 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897978 396 RYRSTLIRHQKVHTGEKPYECSECGKFFMDTStLIIHQRVHTGEKPYECSECGKFFRYCFTLNRHQRVHSGERPYECSEC 475
Cdd:COG5048   182 SNLSLLISSNVSTSIPSSSENSPLSSSYSIPS-SSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASES 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897978 476 GKFFV--DSCTLKSHQRVHTGER-----PFECSICGKSFRCRSTLDTHQR--IHTGE--RPYECSE--CGKFFRHNSNHI 542
Cdd:COG5048   261 PRSSLptASSQSSSPNESDSSSEkgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALK 340

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897978 543 RHRRNHFGERSFEC--TECGRVFSQNS----HLIRHQKVHTRERTYKC---SKCGKFFMDSSTLISHQRVHTGEKPYEC- 612
Cdd:COG5048   341 RHILLHTSISPAKEklLNSSSKFSPLLnnepPQSLQQYKDLKNDKKSEtlsNSCIRNFKRDSNLSLHIITHLSFRPYNCk 420

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 1622897978 613 -SECGKVFRYNSSLIKHRRIHTGERPYQCSECGRvFNQNSHLIQH 656
Cdd:COG5048   421 nPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
KRAB smart00349
krueppel associated box;
8-49 3.05e-13

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 64.54  E-value: 3.05e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1622897978    8 MVFEDVAIHFSQEEWGILNGVQRHLHSDVMLENFALLSSVGC 49
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 10-46 3.93e-12

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 61.03  E-value: 3.93e-12
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1622897978  10 FEDVAIHFSQEEWGILNGVQRHLHSDVMLENFALLSS 46
Cdd:cd07765     3 FEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
zf-H2C2_2 pfam13465
Zinc-finger double domain;
485-509 2.91e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.91e-03
                          10        20
                  ....*....|....*....|....*
gi 1622897978 485 LKSHQRVHTGERPFECSICGKSFRC 509
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 7-48 8.90e-17

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 74.04  E-value: 8.90e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1622897978   7 CMVFEDVAIHFSQEEWGILNGVQRHLHSDVMLENFALLSSVG 48
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
244-656 2.31e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.81  E-value: 2.31e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897978 244 RPYKCSECGKAFSLKYNVVQHQKIHTGERPYECS--ECGKAFLRKSHLLQHQRIHTRPRPYLCSecgKTFLTQAHLVGHQ 321
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNS---KSLPLSNSKASSS 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897978 322 KIH--TGERPYGCNECGKYFM----YSSALIRHQKVHTGERPFYCCECGKFFMDSCTLIIHQRVHTgekpyecNECGKFF 395
Cdd:COG5048   109 SLSssSSNSNDNNLLSSHSLPpssrDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN-------SLSKDPS 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897978 396 RYRSTLIRHQKVHTGEKPYECSECGKFFMDTStLIIHQRVHTGEKPYECSECGKFFRYCFTLNRHQRVHSGERPYECSEC 475
Cdd:COG5048   182 SNLSLLISSNVSTSIPSSSENSPLSSSYSIPS-SSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASES 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897978 476 GKFFV--DSCTLKSHQRVHTGER-----PFECSICGKSFRCRSTLDTHQR--IHTGE--RPYECSE--CGKFFRHNSNHI 542
Cdd:COG5048   261 PRSSLptASSQSSSPNESDSSSEkgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALK 340

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897978 543 RHRRNHFGERSFEC--TECGRVFSQNS----HLIRHQKVHTRERTYKC---SKCGKFFMDSSTLISHQRVHTGEKPYEC- 612
Cdd:COG5048   341 RHILLHTSISPAKEklLNSSSKFSPLLnnepPQSLQQYKDLKNDKKSEtlsNSCIRNFKRDSNLSLHIITHLSFRPYNCk 420

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 1622897978 613 -SECGKVFRYNSSLIKHRRIHTGERPYQCSECGRvFNQNSHLIQH 656
Cdd:COG5048   421 nPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
KRAB smart00349
krueppel associated box;
8-49 3.05e-13

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 64.54  E-value: 3.05e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1622897978    8 MVFEDVAIHFSQEEWGILNGVQRHLHSDVMLENFALLSSVGC 49
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 10-46 3.93e-12

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 61.03  E-value: 3.93e-12
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1622897978  10 FEDVAIHFSQEEWGILNGVQRHLHSDVMLENFALLSS 46
Cdd:cd07765     3 FEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
190-544 9.07e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.01  E-value: 9.07e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897978 190 YSCSQCGKDFCHQRMLFEHQKIHTEERPYECSECGKFFRY--NSDLIKHQRNHTGE----------------RPYKCSEC 251
Cdd:COG5048    34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFsrPLELSRHLRTHHNNpsdlnskslplsnskaSSSSLSSS 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897978 252 GKAFSLKYNVVQH---QKIHTGERPYECSEC----------------GKAFLRKSHLLQHQRIHTRPRPYLCSECGKTFL 312
Cdd:COG5048   114 SSNSNDNNLLSSHslpPSSRDPQLPDLLSISnlrnnplpgnnsssvnTPQSNSLHPPLPANSLSKDPSSNLSLLISSNVS 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897978 313 TQA----------------HLVGHQKIHTGERPYGCNECGKYFMYSSALIRHQKVHTGERPFYCCECGKFFM--DSCTLI 374
Cdd:COG5048   194 TSIpsssensplsssysipSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLptASSQSS 273

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897978 375 IHQRVHTGE-----KPYECNECGKFFRYRSTLIRHQ--KVHTGE--KPYECSE--CGKFFMDTSTLIIHQRVHTGEKPYE 443
Cdd:COG5048   274 SPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAK 353

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897978 444 C--SECGKFFRYCFTLNRHQRVH-----SGERPYEC--SECGKFFVDSCTLKSHQRVHTGERP--FECSICGKSFRCRST 512
Cdd:COG5048   354 EklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYN 433

                         410       420       430
                  ....*....|....*....|....*....|....
gi 1622897978 513 LDTHQRIHTGERPYECSECGKFFR--HNSNHIRH 544
Cdd:COG5048   434 LIPHKKIHTNHAPLLCSILKSFRRdlDLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
356-660 1.95e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.85  E-value: 1.95e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897978 356 RPFYCCECGKFFMDSCTLIIHQRVHTGEKPYECNECGKFFRY--RSTLIRHQKVHTGEKPYECS---------------- 417
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFsrPLELSRHLRTHHNNPSDLNSkslplsnskassssls 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897978 418 ECGKFFMDTSTL---IIHQRVHTGEKPYECSEC---GKFFRYCFTLNRHQRVHSGER---PYECSECGKFFVDSCTLksH 488
Cdd:COG5048   112 SSSSNSNDNNLLsshSLPPSSRDPQLPDLLSISnlrNNPLPGNNSSSVNTPQSNSLHpplPANSLSKDPSSNLSLLI--S 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897978 489 QRVHTGERPFECSICGKSFRCRSTLDTHQRIHTGERPYECSECGKFFRHNSNHIRHRRNHFGERSFECTECGRVFSQNSH 568
Cdd:COG5048   190 SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTAS 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897978 569 LIRHQKVHTRERT-------YKCSKCGKFFMDSSTLISHQR--VHTGE--KPYECSE--CGKVFRYNSSLIKHRRIHTGE 635
Cdd:COG5048   270 SQSSSPNESDSSSekgfslpIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSI 349

                         330       340
                  ....*....|....*....|....*..
gi 1622897978 636 RPYQC--SECGRVFNQNSHLIQHQKVH 660
Cdd:COG5048   350 SPAKEklLNSSSKFSPLLNNEPPQSLQ 376
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
412-661 3.49e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 3.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897978 412 KPYECSECGKFFMDTSTLIIHQRVHTGEKPYECSECGKFFRYCFTLN--RHQRVHSGERPYECS---------------- 473
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLElsRHLRTHHNNPSDLNSkslplsnskassssls 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897978 474 ECGKFFVDSCTLKSH---QRVHTGERPFECSIC--------------------------------GKSFRCRSTLDTHQR 518
Cdd:COG5048   112 SSSSNSNDNNLLSSHslpPSSRDPQLPDLLSISnlrnnplpgnnsssvntpqsnslhpplpanslSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897978 519 IHTGERPYECSECGKFFRHNSNHIRHRRNHFGERSFECTECGRVFSQNSHLIRHQKVHTRERTYKCSKCGKFFMDSSTLI 598
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622897978 599 SHQRVHTGE-------KPYECSECGKVFRYNSSLIKHRR--IHTGE--RPYQCSE--CGRVFNQNSHLIQHQKVHT 661
Cdd:COG5048   272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHT 347
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
563-641 1.72e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 1.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897978 563 FSQNSHLIRHQKVHTRE------RTYKCSKCGKFFMDSSTLISHQRVHTGEKPYECSECGKVFRY--NSSLIKHRRIHTG 634
Cdd:COG5048     9 SSSNNSVLSSTPKSTLKslsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFsrPLELSRHLRTHHN 88


                  ....*..
gi 1622897978 635 ERPYQCS 641
Cdd:COG5048    89 NPSDLNS 95
zf-H2C2_2 pfam13465
Zinc-finger double domain;
485-509 2.91e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.91e-03
                          10        20
                  ....*....|....*....|....*
gi 1622897978 485 LKSHQRVHTGERPFECSICGKSFRC 509
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
232-256 3.98e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.98e-03
                          10        20
                  ....*....|....*....|....*
gi 1622897978 232 DLIKHQRNHTGERPYKCSECGKAFS 256
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
513-537 5.19e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.19e-03
                          10        20
                  ....*....|....*....|....*
gi 1622897978 513 LDTHQRIHTGERPYECSECGKFFRH 537
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
260-285 6.70e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.70e-03
                          10        20
                  ....*....|....*....|....*.
gi 1622897978 260 NVVQHQKIHTGERPYECSECGKAFLR 285
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 554-576 9.04e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 9.04e-03
                          10        20
                  ....*....|....*....|...
gi 1622897978 554 FECTECGRVFSQNSHLIRHQKVH 576
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
597-621 9.36e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 9.36e-03
                          10        20
                  ....*....|....*....|....*
gi 1622897978 597 LISHQRVHTGEKPYECSECGKVFRY 621
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
457-480 9.83e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 9.83e-03
                          10        20
                  ....*....|....*....|....
gi 1622897978 457 LNRHQRVHSGERPYECSECGKFFV 480
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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