NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|967499814|ref|XP_014980258|]
View 

zinc finger protein 83 isoform X3 [Macaca mulatta]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
171-504 3.40e-11

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.49  E-value: 3.40e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967499814 171 KQLKCDICGKSFNKKSNLASHRRIHTGEKPYKCN--ECGKVFNNISHLAQHRRIHTGEKPYKCNECG------KVFNQIS 242
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLplsnskASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967499814 243 HLAQHQRIHTGEKPYKCNecGKVFHQISHLAQHRTIHTGEKPYKCNKCGKVFSRNSYLIQHLIIHtgekpykcNECGKVF 322
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLP--PSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN--------SLSKDPS 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967499814 323 NHISHLAQHRRIHTGEKPYKCNECGKvFSHKSSLANHWRIHTGEKPYKCNECGKVFSRNSYLAQHLLIHTGEKPFKCDEC 402
Cdd:COG5048  182 SNLSLLISSNVSTSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASES 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967499814 403 NKAFSQNSHLVQHRRIHTGE-------KPYKCNECGKVFSQNSYLAYHRR--IHTGE--KPYKCNE--CGKVFSLNSSLA 469
Cdd:COG5048  261 PRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALK 340

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 967499814 470 HHRKIHTGEKPYKCNECGKAFSVRSSLTNHHVTHT 504
Cdd:COG5048  341 RHILLHTSISPAKEKLLNSSSKFSPLLNNEPPQSL 375
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
171-504 3.40e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.49  E-value: 3.40e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967499814 171 KQLKCDICGKSFNKKSNLASHRRIHTGEKPYKCN--ECGKVFNNISHLAQHRRIHTGEKPYKCNECG------KVFNQIS 242
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLplsnskASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967499814 243 HLAQHQRIHTGEKPYKCNecGKVFHQISHLAQHRTIHTGEKPYKCNKCGKVFSRNSYLIQHLIIHtgekpykcNECGKVF 322
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLP--PSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN--------SLSKDPS 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967499814 323 NHISHLAQHRRIHTGEKPYKCNECGKvFSHKSSLANHWRIHTGEKPYKCNECGKVFSRNSYLAQHLLIHTGEKPFKCDEC 402
Cdd:COG5048  182 SNLSLLISSNVSTSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASES 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967499814 403 NKAFSQNSHLVQHRRIHTGE-------KPYKCNECGKVFSQNSYLAYHRR--IHTGE--KPYKCNE--CGKVFSLNSSLA 469
Cdd:COG5048  261 PRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALK 340

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 967499814 470 HHRKIHTGEKPYKCNECGKAFSVRSSLTNHHVTHT 504
Cdd:COG5048  341 RHILLHTSISPAKEKLLNSSSKFSPLLNNEPPQSL 375
zf-H2C2_2 pfam13465
Zinc-finger double domain;
215-240 8.24e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 8.24e-04
                          10        20
                  ....*....|....*....|....*.
gi 967499814  215 HLAQHRRIHTGEKPYKCNECGKVFNQ 240
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 199-251 2.26e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.15  E-value: 2.26e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 967499814 199 KPYkCNECGKVFNNISHLAQHRRIHTgekpYKCNECGKVFNQISHLAQH-QRIH 251
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
171-504 3.40e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.49  E-value: 3.40e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967499814 171 KQLKCDICGKSFNKKSNLASHRRIHTGEKPYKCN--ECGKVFNNISHLAQHRRIHTGEKPYKCNECG------KVFNQIS 242
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLplsnskASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967499814 243 HLAQHQRIHTGEKPYKCNecGKVFHQISHLAQHRTIHTGEKPYKCNKCGKVFSRNSYLIQHLIIHtgekpykcNECGKVF 322
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLP--PSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN--------SLSKDPS 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967499814 323 NHISHLAQHRRIHTGEKPYKCNECGKvFSHKSSLANHWRIHTGEKPYKCNECGKVFSRNSYLAQHLLIHTGEKPFKCDEC 402
Cdd:COG5048  182 SNLSLLISSNVSTSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASES 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967499814 403 NKAFSQNSHLVQHRRIHTGE-------KPYKCNECGKVFSQNSYLAYHRR--IHTGE--KPYKCNE--CGKVFSLNSSLA 469
Cdd:COG5048  261 PRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALK 340

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 967499814 470 HHRKIHTGEKPYKCNECGKAFSVRSSLTNHHVTHT 504
Cdd:COG5048  341 RHILLHTSISPAKEKLLNSSSKFSPLLNNEPPQSL 375
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
106-500 1.67e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.09  E-value: 1.67e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967499814 106 SPPQGISSTVKTHVSHTHAYNFVDSLFTQKEKANIGTEHYKCNECGKSFHQGLHFTIHQIIHAEEKQLKCDICGKSFNKK 185
Cdd:COG5048   54 RSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSR 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967499814 186 SNLASHRRIHT---GEKPYKCNECGKVFNNISHL-AQHRRIHTGEKPYKCNecgkvfnqisHLAQHQRIHTGEKPYKCNE 261
Cdd:COG5048  134 DPQLPDLLSISnlrNNPLPGNNSSSVNTPQSNSLhPPLPANSLSKDPSSNL----------SLLISSNVSTSIPSSSENS 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967499814 262 CGKVFHQISHLAQHRTIHTGEKPYKCNKCGKVFSRNSYLIQHLIIHTGEKPYKCNECGKVFNHISHLAQHRRIHTGE--- 338
Cdd:COG5048  204 PLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSsse 283

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967499814 339 ----KPYKCNECGKVFSHKSSLANHWR--IHTGE--KPYKCNE--CGKVFSRNSYLAQHLLIHTGEKPFKC--DECNKAF 406
Cdd:COG5048  284 kgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKF 363

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967499814 407 SQNSH-----LVQHRRIHTGEKPYKC--NECGKVFSQNSYLAYHRRIHTGEKPY--KCNECGKVFSLNSSLAHHRKIHTg 477
Cdd:COG5048  364 SPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHT- 442

                        410       420
                 ....*....|....*....|...
gi 967499814 478 EKPYKCNECGKAFSVRSSLTNHH 500
Cdd:COG5048  443 NHAPLLCSILKSFRRDLDLSNHG 465
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
227-539 6.61e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.01  E-value: 6.61e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967499814 227 KPYKCNECGKVFNQISHLAQHQRIHTGEKPYKCN--ECGKVFHQISHLAQHRTIHTGEKPYKCNKCGKvfSRNSYLIQHL 304
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP--LSNSKASSSS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967499814 305 IIHTGEKPYKCN-ECGKVFNHISHLAQHRRIHTGEKPYKCNECGKVFSHKSSLANHWRIHTGEKPYKCNECGKVFSRNSy 383
Cdd:COG5048  110 LSSSSSNSNDNNlLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLI- 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967499814 384 laqHLLIHTGEKPFKCDECNKAFSQNSHLVQHRRIHTGEKPYKCNECGKVFSQNSYLAYHRRIHTGEKPYKCNECGKVFS 463
Cdd:COG5048  189 ---SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967499814 464 LNSSLAHHRKIHTGE-------KPYKCNECGKAFSVRSSLTNH--HVTHTGE--KPFKCNE--CGKLFRDSSYLVGHQRF 530
Cdd:COG5048  266 PTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345


                 ....*....
gi 967499814 531 HAGEESNKC 539
Cdd:COG5048  346 HTSISPAKE 354
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
180-444 1.90e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.46  E-value: 1.90e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967499814 180 KSFNKKSNLASHRRIHTGEKPYKCNECGKVFNNISHLAQHRRIHTGEKPYKCNECGKVFNQISHLAQHQRIHTGEKPYKC 259
Cdd:COG5048  178 KDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSA 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967499814 260 NECGKVFHQISHLAQHRTIHTGE-------KPYKCNKCGKVFSRNSYLIQHL--IIHTGE--KPYKCNE--CGKVFNHIS 326
Cdd:COG5048  258 SESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRND 337

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967499814 327 HLAQHRRIHTGEKPYKC--NECGKVFSHKS-----SLANHWRIHTGEKPYKC--NECGKVFSRNSYLAQHLLIHTGEKP- 396
Cdd:COG5048  338 ALKRHILLHTSISPAKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPy 417

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 967499814 397 -FKCDECNKAFSQNSHLVQHRRIHTGEKPYKCNECGKVFSQNSYLAYHR 444
Cdd:COG5048  418 nCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
219-472 9.09e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.07  E-value: 9.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967499814 219 HRRIHTGEKPYKCNECGKVFNQISHLAQHQRIHTGEKPYKCNECGKVFHQISHLAQHRTIHTGEKPYKCNKCGKVFSRNS 298
Cdd:COG5048  189 SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTA 268

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967499814 299 YLIQHLIIHTGE-------KPYKCNECGKVFNHISHLAQHRR--IHTGE--KPYKCNE--CGKVFSHKSSLANHWRIHTG 365
Cdd:COG5048  269 SSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967499814 366 EKPYKC--NECGKVFSRNSYLAQHLLIH-----TGEKPFKCD--ECNKAFSQNSHLVQHRRIHTGEKPY--KCNECGKVF 434
Cdd:COG5048  349 ISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSF 428

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 967499814 435 SQNSYLAYHRRIHTGEKPYKCNECGKVFSLNSSLAHHR 472
Cdd:COG5048  429 NRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
215-240 8.24e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 8.24e-04
                          10        20
                  ....*....|....*....|....*.
gi 967499814  215 HLAQHRRIHTGEKPYKCNECGKVFNQ 240
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
327-352 9.01e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 9.01e-04
                          10        20
                  ....*....|....*....|....*.
gi 967499814  327 HLAQHRRIHTGEKPYKCNECGKVFSH 352
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
411-436 1.04e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.04e-03
                          10        20
                  ....*....|....*....|....*.
gi 967499814  411 HLVQHRRIHTGEKPYKCNECGKVFSQ 436
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
187-212 1.10e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.10e-03
                          10        20
                  ....*....|....*....|....*.
gi 967499814  187 NLASHRRIHTGEKPYKCNECGKVFNN 212
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 393-473 1.19e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 1.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967499814 393 GEKPFKCD--ECNKAFSQNSHLVQHRRihTGEKPYKCNECGKVFSQNSYLAyhrrihtGEKPYKCNECGKVFSLNSSLAH 470
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHML--HGHQNQKLHENPSPEKMNIFSA-------KDKPYRCEVCDKRYKNLNGLKY 416


                 ...
gi 967499814 471 HRK 473
Cdd:COG5189  417 HRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
243-266 1.49e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.49e-03
                          10        20
                  ....*....|....*....|....
gi 967499814  243 HLAQHQRIHTGEKPYKCNECGKVF 266
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 199-251 2.26e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.15  E-value: 2.26e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 967499814 199 KPYkCNECGKVFNNISHLAQHRRIHTgekpYKCNECGKVFNQISHLAQH-QRIH 251
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 227-275 2.98e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.77  E-value: 2.98e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 967499814 227 KPYkCNECGKVFNQISHLAQHQRIHTgekpYKCNECGKVFHQISHLAQH 275
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 365-444 3.10e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 3.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967499814 365 GEKPYKCN--ECGKVFSRNSYLAQHLLiHtgekpfkcDECNKAFSQNSHLVQHRRIHTGEKPYKCNECGKVFSQNSYLAY 442
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHML-H--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ..
gi 967499814 443 HR 444
Cdd:COG5189  417 HR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 394-504 3.53e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 3.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967499814 394 EKPFKCDECNKAFSQNSHL---VQHRRIHT-GEKPYKCN--ECGKVFSQNSYLAYHRrihtgekpyKCNECGKVFSLNSS 467
Cdd:COG5189  315 KLPCTNSSSNGKLAHGGERnidTPSRMLKVkDGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPS 385

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 967499814 468 LAHHRKIHTGEKPYKCNECGKAFSVRSSLtNHHVTHT 504
Cdd:COG5189  386 PEKMNIFSAKDKPYRCEVCDKRYKNLNGL-KYHRKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
439-463 4.46e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.46e-03
                          10        20
                  ....*....|....*....|....*
gi 967499814  439 YLAYHRRIHTGEKPYKCNECGKVFS 463
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
383-408 4.55e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.55e-03
                          10        20
                  ....*....|....*....|....*.
gi 967499814  383 YLAQHLLIHTGEKPFKCDECNKAFSQ 408
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
299-324 4.60e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.60e-03
                          10        20
                  ....*....|....*....|....*.
gi 967499814  299 YLIQHLIIHTGEKPYKCNECGKVFNH 324
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
271-296 7.66e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.66e-03
                          10        20
                  ....*....|....*....|....*.
gi 967499814  271 HLAQHRTIHTGEKPYKCNKCGKVFSR 296
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 311-363 8.10e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 35.61  E-value: 8.10e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 967499814 311 KPYkCNECGKVFNHISHLAQHRRIHTgekpYKCNECGKVFSHKSSLANH-WRIH 363
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH