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Conserved domains on  [gi|967499641|ref|XP_014980179|]
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myeloid cell surface antigen CD33 isoform X1 [Macaca mulatta]

Protein Classification

Ig_Siglec_N and Ig domain-containing protein( domain architecture ID 10145902)

Ig_Siglec_N and Ig domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgV_CD33 cd05712
Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic ...
 22-138 2.78e-59

Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic acid-binding Ig-like lectins); The members here are composed of the immunoglobulin (Ig) domain at the N-terminus of Cluster of Differentiation (CD) 33 and related Siglecs (sialic acid-binding Ig-like lectins). Siglec refers to a structurally related protein family that specifically recognizes sialic acid in oligosaccharide chains of glycoproteins and glycolipids. Siglecs are type I transmembrane proteins, organized as an extracellular module composed of Ig-like domains, an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains, followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG, the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11.


:

Pssm-ID: 409377  Cd Length: 119  Bit Score: 187.21  E-value: 2.78e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967499641  22 LEVQESVTVQEGLCVLVPCTFFHPVPYHtRNSPVHGYWFREGAIVSLDSPVATNKLDQEVREETQGRFRLLGDPSRNNCS 101
Cdd:cd05712    3 LQMPKSVTVQEGLCVLIPCSFSYPADYW-VSNPVHGYWYRGGPYPKYRPPVATNNRTREVHESTQGRFRLLGDPGKKNCS 81

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 967499641 102 LSIVDTRRRDNGSYFFRMEKG-STKYSYKSTQLSVHVT 138
Cdd:cd05712   82 LSISDARPEDSGKYFFRVERGdSNKYSYLSNQLSLTVT 119
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 144-229 3.11e-36

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd20987:

Pssm-ID: 472250  Cd Length: 94  Bit Score: 126.92  E-value: 3.11e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967499641 144 PQILIPGALDPDHSKNLTCSVPWACEQGtPPIFSWMSAAPTSL---------GLRTTHSSVLIITPRPQDHGTNLTCQVK 214
Cdd:cd20987    1 PNIHVPEELEAGQEVTLTCSVPDNCPAL-SPEFSWLGAALTPLppvlgrleeEGTTTHSSVLTFTPRPEDHGTNLTCQVK 79

                         90
                 ....*....|....*
gi 967499641 215 FPGAGVTTERTIQLN 229
Cdd:cd20987   80 FPGATVTTERTIQLN 94
 
Name Accession Description Interval E-value
IgV_CD33 cd05712
Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic ...
 22-138 2.78e-59

Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic acid-binding Ig-like lectins); The members here are composed of the immunoglobulin (Ig) domain at the N-terminus of Cluster of Differentiation (CD) 33 and related Siglecs (sialic acid-binding Ig-like lectins). Siglec refers to a structurally related protein family that specifically recognizes sialic acid in oligosaccharide chains of glycoproteins and glycolipids. Siglecs are type I transmembrane proteins, organized as an extracellular module composed of Ig-like domains, an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains, followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG, the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11.


Pssm-ID: 409377  Cd Length: 119  Bit Score: 187.21  E-value: 2.78e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967499641  22 LEVQESVTVQEGLCVLVPCTFFHPVPYHtRNSPVHGYWFREGAIVSLDSPVATNKLDQEVREETQGRFRLLGDPSRNNCS 101
Cdd:cd05712    3 LQMPKSVTVQEGLCVLIPCSFSYPADYW-VSNPVHGYWYRGGPYPKYRPPVATNNRTREVHESTQGRFRLLGDPGKKNCS 81

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 967499641 102 LSIVDTRRRDNGSYFFRMEKG-STKYSYKSTQLSVHVT 138
Cdd:cd05712   82 LSISDARPEDSGKYFFRVERGdSNKYSYLSNQLSLTVT 119
IgC2_CD33_d2_like cd20987
Second immunoglobulin domain of Cluster of Differentiation (CD) 33 and related Siglecs; member ...
 144-229 3.11e-36

Second immunoglobulin domain of Cluster of Differentiation (CD) 33 and related Siglecs; member of the C2-set of IgSF domains; The members here are composed of the second immunoglobulin (Ig) domain of Cluster of Differentiation (CD) 33 (also known as sialic-acid binding immunoglobulin type-lectin 3 (Siglec-3)) and related Siglecs. CD33, a Siglec family member, is a well-known immunotherapeutic target in acute myeloid leukemia (AML). It is an inhibitory sialoadhesin expressed in human leukocytes of the myeloid lineage and some lymphoid subsets, including natural killer (NK) cells. Siglecs are primarily expressed on immune cells and recognize sialic acid-containing glycan ligands. Siglecs are organized as an extracellular module composed of Ig-like domains (an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains), followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG (Siglec-4, myelin-associated glycoprotein), the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11. CD33 (Siglec-3) is the smallest Siglec member. It preferentially binds to alpha2-6- and alpha2-3-sialylated glycans and strongly binds to sialylated ligands on leukemic cell lines. Ig Superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group includes CD33-related Siglecs which belong to the C2-set of IgSF domains. Unlike the C1-set, the C2-set structures do not have a D strand.


Pssm-ID: 409579  Cd Length: 94  Bit Score: 126.92  E-value: 3.11e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967499641 144 PQILIPGALDPDHSKNLTCSVPWACEQGtPPIFSWMSAAPTSL---------GLRTTHSSVLIITPRPQDHGTNLTCQVK 214
Cdd:cd20987    1 PNIHVPEELEAGQEVTLTCSVPDNCPAL-SPEFSWLGAALTPLppvlgrleeEGTTTHSSVLTFTPRPEDHGTNLTCQVK 79

                         90
                 ....*....|....*
gi 967499641 215 FPGAGVTTERTIQLN 229
Cdd:cd20987   80 FPGATVTTERTIQLN 94
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 23-136 7.45e-13

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 64.40  E-value: 7.45e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967499641   23 EVQESVTVQEGLCVLVPCTffhpvpYHTRNSPVHG--YWFREGAIVSLDSPVATNKLDQEVrEETQGRFRLLGDPSRNNC 100
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCT------YSSSMSEASTsvYWYRQPPGKGPTFLIAYYSNGSEE-GVKKGRFSGRGDPSNGDG 73

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 967499641  101 SLSIVDTRRRDNGSYFFRMEKGSTKYSYKSTQLSVH 136
Cdd:pfam07686  74 SLTIQNLTLSDSGTYTCAVIPSGEGVFGKGTRLTVL 109
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 25-135 4.33e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 38.64  E-value: 4.33e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967499641    25 QESVTVQEGLCVLVPCTFFHpvpyhtrNSPVHGYWFREGAIVSLDSPvatnkldqevreetqgrfRLLGDPSRNNCSLSI 104
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASG-------SPPPEVTWYKQGGKLLAESG------------------RFSVSRSGSTSTLTI 55

                           90       100       110
                   ....*....|....*....|....*....|.
gi 967499641   105 VDTRRRDNGSYFFRMEKGSTKYSyKSTQLSV 135
Cdd:smart00410  56 SNVTPEDSGTYTCAATNSSGSAS-SGTTLTV 85
C2-set_2 pfam08205
CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.
 144-217 2.08e-03

CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.


Pssm-ID: 400489  Cd Length: 89  Bit Score: 37.01  E-value: 2.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967499641  144 PQILIPGAldPDHSKNLTCSVpwaCEQGTPPIFSWMSAAPTSLGLRT-----------THSSVLIITPRPQDHGTNLTCQ 212
Cdd:pfam08205   5 PPASLLEG--EGPEVVATCSS---AGGKPAPRITWYLDGKPLEAAETsseqdpesglvTVTSELKLVPSRSDHGQSLTCQ 79


                  ....*
gi 967499641  213 VKFPG 217
Cdd:pfam08205  80 VSYGA 84
 
Name Accession Description Interval E-value
IgV_CD33 cd05712
Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic ...
 22-138 2.78e-59

Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic acid-binding Ig-like lectins); The members here are composed of the immunoglobulin (Ig) domain at the N-terminus of Cluster of Differentiation (CD) 33 and related Siglecs (sialic acid-binding Ig-like lectins). Siglec refers to a structurally related protein family that specifically recognizes sialic acid in oligosaccharide chains of glycoproteins and glycolipids. Siglecs are type I transmembrane proteins, organized as an extracellular module composed of Ig-like domains, an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains, followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG, the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11.


Pssm-ID: 409377  Cd Length: 119  Bit Score: 187.21  E-value: 2.78e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967499641  22 LEVQESVTVQEGLCVLVPCTFFHPVPYHtRNSPVHGYWFREGAIVSLDSPVATNKLDQEVREETQGRFRLLGDPSRNNCS 101
Cdd:cd05712    3 LQMPKSVTVQEGLCVLIPCSFSYPADYW-VSNPVHGYWYRGGPYPKYRPPVATNNRTREVHESTQGRFRLLGDPGKKNCS 81

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 967499641 102 LSIVDTRRRDNGSYFFRMEKG-STKYSYKSTQLSVHVT 138
Cdd:cd05712   82 LSISDARPEDSGKYFFRVERGdSNKYSYLSNQLSLTVT 119
IgC2_CD33_d2_like cd20987
Second immunoglobulin domain of Cluster of Differentiation (CD) 33 and related Siglecs; member ...
 144-229 3.11e-36

Second immunoglobulin domain of Cluster of Differentiation (CD) 33 and related Siglecs; member of the C2-set of IgSF domains; The members here are composed of the second immunoglobulin (Ig) domain of Cluster of Differentiation (CD) 33 (also known as sialic-acid binding immunoglobulin type-lectin 3 (Siglec-3)) and related Siglecs. CD33, a Siglec family member, is a well-known immunotherapeutic target in acute myeloid leukemia (AML). It is an inhibitory sialoadhesin expressed in human leukocytes of the myeloid lineage and some lymphoid subsets, including natural killer (NK) cells. Siglecs are primarily expressed on immune cells and recognize sialic acid-containing glycan ligands. Siglecs are organized as an extracellular module composed of Ig-like domains (an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains), followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG (Siglec-4, myelin-associated glycoprotein), the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11. CD33 (Siglec-3) is the smallest Siglec member. It preferentially binds to alpha2-6- and alpha2-3-sialylated glycans and strongly binds to sialylated ligands on leukemic cell lines. Ig Superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group includes CD33-related Siglecs which belong to the C2-set of IgSF domains. Unlike the C1-set, the C2-set structures do not have a D strand.


Pssm-ID: 409579  Cd Length: 94  Bit Score: 126.92  E-value: 3.11e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967499641 144 PQILIPGALDPDHSKNLTCSVPWACEQGtPPIFSWMSAAPTSL---------GLRTTHSSVLIITPRPQDHGTNLTCQVK 214
Cdd:cd20987    1 PNIHVPEELEAGQEVTLTCSVPDNCPAL-SPEFSWLGAALTPLppvlgrleeEGTTTHSSVLTFTPRPEDHGTNLTCQVK 79

                         90
                 ....*....|....*
gi 967499641 215 FPGAGVTTERTIQLN 229
Cdd:cd20987   80 FPGATVTTERTIQLN 94
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 23-136 7.45e-13

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 64.40  E-value: 7.45e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967499641   23 EVQESVTVQEGLCVLVPCTffhpvpYHTRNSPVHG--YWFREGAIVSLDSPVATNKLDQEVrEETQGRFRLLGDPSRNNC 100
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCT------YSSSMSEASTsvYWYRQPPGKGPTFLIAYYSNGSEE-GVKKGRFSGRGDPSNGDG 73

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 967499641  101 SLSIVDTRRRDNGSYFFRMEKGSTKYSYKSTQLSVH 136
Cdd:pfam07686  74 SLTIQNLTLSDSGTYTCAVIPSGEGVFGKGTRLTVL 109
IgC1_CD22_d2 cd20938
Second immunoglobulin domain of Cluster of Differentiation (CD) 22; member of the Constant 1 ...
 144-230 9.92e-08

Second immunoglobulin domain of Cluster of Differentiation (CD) 22; member of the Constant 1 (C1)-set of IgSF domains; The members here are composed of the second immunoglobulin domain of clusters of differentiation (CD) 22 (also known as Siglec-2). CD22, a sialic-acid binding immunoglobulin type-lectin (Siglec) family member, is an inhibitory co-receptor of the B-cell receptor (BCR). The inhibitory function of CD22 and its restricted expression on B cells makes CD22 an attractive target against dysregulated B cells that cause autoimmune diseases and B-cell-derived cancers. CD22 plays a vital role in establishing a baseline level of B-cell inhibition, and thus is an important determinant of homeostasis in humoral immunity. Siglecs are primarily expressed on immune cells and recognize sialic acid-containing glycan ligands. Siglecs are organized as an extracellular module composed of Ig-like domains (an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains), followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG (Siglec-4, myelin-associated glycoprotein), the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group belongs to the C1-set of IgSF domains.


Pssm-ID: 409532  Cd Length: 98  Bit Score: 49.56  E-value: 9.92e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967499641 144 PQILIPGALDPDHSKNLTCSVPWACeQGTPPIFSWM-------SAAPTSLGLRTTH---SSVLIITPRPQDHGTNLTCQV 213
Cdd:cd20938    3 PHIQLPPEIQESQEVTLTCLLNFSC-YGYPIQLQWLlegspmrQAAVTSTSLTIKSvftRSELKFQPKWSHHGKIVTCQL 81

                         90
                 ....*....|....*..
gi 967499641 214 KFPGAGVTTERTIQLNV 230
Cdd:cd20938   82 QDADGKVLSEDTVQLNV 98
IgV_CD22_d1 cd20929
First immunoglobulin domain of Cluster of Differentiation (CD) 22; member of the V-set of IgSF ...
 26-126 2.58e-07

First immunoglobulin domain of Cluster of Differentiation (CD) 22; member of the V-set of IgSF domains; The members here are composed of the first immunoglobulin domain in Cluster of Differentiation (CD) 22 (also known as Siglec-2). CD22, a sialic-acid binding immunoglobulin type-lectin (Siglec) family member, is an inhibitory co-receptor of the B-cell receptor (BCR). The inhibitory function of CD22 and its restricted expression on B cells makes CD22 an attractive target against dysregulated B cells that cause autoimmune diseases and B-cell-derived cancers. CD22 plays a vital role in establishing a baseline level of B-cell inhibition, and thus is an important determinant of homeostasis in humoral immunity. Siglecs are primarily expressed on immune cells and recognize sialic acid-containing glycan ligands. Siglecs are organized as an extracellular module composed of Ig-like domains (an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains), followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG (Siglec-4, myelin-associated glycoprotein), the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group belongs to the V-set of IgSF domains.


Pssm-ID: 409523  Cd Length: 114  Bit Score: 48.84  E-value: 2.58e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967499641  26 ESVTVQEGLCVLVPCTFFHPVPYHTRNSPVHGYWFREgAIVSLDSPVATNKLDQEVREETQGRFRLLGDpSRNNCSLSIV 105
Cdd:cd20929    7 ETLYAWEGACVWIPCTYRALDGDLESFILFHNPEYNK-ATSKFDGTRLYESTKDGKVPSEQKRVQFLGD-KNKNCTLSIH 84

                         90       100
                 ....*....|....*....|.
gi 967499641 106 DTRRRDNGSYFFRMEKGSTKY 126
Cdd:cd20929   85 PVHLNDSGQLGLRMESKTEKW 105
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 25-135 4.33e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 38.64  E-value: 4.33e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967499641    25 QESVTVQEGLCVLVPCTFFHpvpyhtrNSPVHGYWFREGAIVSLDSPvatnkldqevreetqgrfRLLGDPSRNNCSLSI 104
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASG-------SPPPEVTWYKQGGKLLAESG------------------RFSVSRSGSTSTLTI 55

                           90       100       110
                   ....*....|....*....|....*....|.
gi 967499641   105 VDTRRRDNGSYFFRMEKGSTKYSyKSTQLSV 135
Cdd:smart00410  56 SNVTPEDSGTYTCAATNSSGSAS-SGTTLTV 85
C2-set_2 pfam08205
CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.
 144-217 2.08e-03

CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.


Pssm-ID: 400489  Cd Length: 89  Bit Score: 37.01  E-value: 2.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967499641  144 PQILIPGAldPDHSKNLTCSVpwaCEQGTPPIFSWMSAAPTSLGLRT-----------THSSVLIITPRPQDHGTNLTCQ 212
Cdd:pfam08205   5 PPASLLEG--EGPEVVATCSS---AGGKPAPRITWYLDGKPLEAAETsseqdpesglvTVTSELKLVPSRSDHGQSLTCQ 79


                  ....*
gi 967499641  213 VKFPG 217
Cdd:pfam08205  80 VSYGA 84
IGv smart00406
Immunoglobulin V-Type;
38-116 5.15e-03

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 35.44  E-value: 5.15e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967499641    38 VPCTFfhpvpYHTRNSPVHGYWFREGA-----IVSLDSPVATNKLDQEVReetqGRFRLLGDPSRNNCSLSIVDTRRRDN 112
Cdd:smart00406   4 LSCKF-----SGSTFSSYYVSWVRQPPgkgleWLGYIGSNGSSYYQESYK----GRFTISKDTSKNDVSLTISNLRVEDT 74


                   ....
gi 967499641   113 GSYF 116
Cdd:smart00406  75 GTYY 78
IgV_TCR_alpha cd04983
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar ...
 25-136 8.23e-03

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar proteins; The members here are composed of the immunoglobulin (Ig) variable domain of the alpha chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta polypeptide chains with variable (V) and constant (C) regions. This group represents the variable domain of the alpha chain of TCRs and also includes the variable domain of delta chains of TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409372 [Multi-domain]  Cd Length: 109  Bit Score: 35.71  E-value: 8.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967499641  25 QESVTVQEGLCVLVPCTffhpvpYHTRNSPvHGYWFRE---GAIVSLDSPVATNkldqevREETQGRFRLLGDPSRNNCS 101
Cdd:cd04983    5 PQSLSVQEGENVTLNCN------YSTSTFY-YLFWYRQypgQGPQFLIYISSDS------GNKKKGRFSATLDKSRKSSS 71

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 967499641 102 LSIVDTRRRDNGSYF--FRMEKGSTKYSY-KSTQLSVH 136
Cdd:cd04983   72 LHISAAQLSDSAVYFcaLSESGGTGKLTFgKGTRLTVE 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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