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Conserved domains on  [gi|1622897691|ref|XP_014979703|]
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zinc finger protein 112 isoform X1 [Macaca mulatta]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204378)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
8-68 6.33e-26

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 101.13  E-value: 6.33e-26
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622897691    8 VTFKDVAVVFTEEELGLLDSVQRKLYRDVMLENFRNLLLVAHQPFKPDLISQLEREEKLLM 68
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
365-756 4.46e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.18  E-value: 4.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897691 365 EKAFSHSLDLNSIFRVHTRDEPHE--YEENENVFNQSSCLQVHQKIHTEEKLYT--DVEYGKSFICSSNLDIQHRVHmee 440
Cdd:COG5048    40 TDSFSRLEHLTRHIRSHTGEKPSQcsYSGCDKSFSRPLELSRHLRTHHNNPSDLnsKSLPLSNSKASSSSLSSSSSN--- 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897691 441 NSYNSEECGNDFSLASHFQDLQIVHTKEQPYKRYVCGNSFSHNLYLQGHPKIHIGEKPHKDCGNGFNWSSKLkdHQRVHT 520
Cdd:COG5048   117 SNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLI--SSNVST 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897691 521 GQKPYKCNICGKGFNHRSVLNVHQRVHTGEKPYKCEECDKGFSRSSYLQAHQRVHTGEKPYKCEECGKGF--SRNSYLQG 598
Cdd:COG5048   195 SIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSlpTASSQSSS 274

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897691 599 HQRVHTGE-----KPYKCEECGKGFSRSSHLQGHQR--VHTGE--KPFKCEE--CGKGFSWSFNLQIHQRVHTGEKPYKC 667
Cdd:COG5048   275 PNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKE 354

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897691 668 --EECGKGFSKASTLLAHQRVH-----TGEKPYQCD--ECGKSFSQRSYLQSHQSVHSGERP--YICEVCGKGFSQRAYL 736
Cdd:COG5048   355 klLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNL 434

                         410       420
                  ....*....|....*....|
gi 1622897691 737 QGHQRVHTRVKPYKCEMCGK 756
Cdd:COG5048   435 IPHKKIHTNHAPLLCSILKS 454
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 763-856 7.68e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.25  E-value: 7.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897691 763 RLEAHRRVHTGGKPYKCEV--CTKGFSESSRLQAHqRVHAEGRPYKCEQcgkgfsgySSLQAHHRVHTGEKPYKCEVCGK 840
Cdd:COG5189   336 DTPSRMLKVKDGKPYKCPVegCNKKYKNQNGLKYH-MLHGHQNQKLHEN--------PSPEKMNIFSAKDKPYRCEVCDK 406

                          90
                  ....*....|....*.
gi 1622897691 841 GFSQRSNLQAHqRVHT 856
Cdd:COG5189   407 RYKNLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
847-870 1.35e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.35e-03
                          10        20
                  ....*....|....*....|....
gi 1622897691 847 NLQAHQRVHTGEKPYKCDACGKGF 870
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
8-68 6.33e-26

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 101.13  E-value: 6.33e-26
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622897691    8 VTFKDVAVVFTEEELGLLDSVQRKLYRDVMLENFRNLLLVAHQPFKPDLISQLEREEKLLM 68
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 7-47 4.83e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 80.98  E-value: 4.83e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1622897691   7 MVTFKDVAVVFTEEELGLLDSVQRKLYRDVMLENFRNLLLV 47
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 8-44 4.10e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 69.89  E-value: 4.10e-15
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1622897691   8 VTFKDVAVVFTEEELGLLDSVQRKLYRDVMLENFRNL 44
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
365-756 4.46e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.18  E-value: 4.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897691 365 EKAFSHSLDLNSIFRVHTRDEPHE--YEENENVFNQSSCLQVHQKIHTEEKLYT--DVEYGKSFICSSNLDIQHRVHmee 440
Cdd:COG5048    40 TDSFSRLEHLTRHIRSHTGEKPSQcsYSGCDKSFSRPLELSRHLRTHHNNPSDLnsKSLPLSNSKASSSSLSSSSSN--- 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897691 441 NSYNSEECGNDFSLASHFQDLQIVHTKEQPYKRYVCGNSFSHNLYLQGHPKIHIGEKPHKDCGNGFNWSSKLkdHQRVHT 520
Cdd:COG5048   117 SNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLI--SSNVST 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897691 521 GQKPYKCNICGKGFNHRSVLNVHQRVHTGEKPYKCEECDKGFSRSSYLQAHQRVHTGEKPYKCEECGKGF--SRNSYLQG 598
Cdd:COG5048   195 SIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSlpTASSQSSS 274

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897691 599 HQRVHTGE-----KPYKCEECGKGFSRSSHLQGHQR--VHTGE--KPFKCEE--CGKGFSWSFNLQIHQRVHTGEKPYKC 667
Cdd:COG5048   275 PNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKE 354

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897691 668 --EECGKGFSKASTLLAHQRVH-----TGEKPYQCD--ECGKSFSQRSYLQSHQSVHSGERP--YICEVCGKGFSQRAYL 736
Cdd:COG5048   355 klLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNL 434

                         410       420
                  ....*....|....*....|
gi 1622897691 737 QGHQRVHTRVKPYKCEMCGK 756
Cdd:COG5048   435 IPHKKIHTNHAPLLCSILKS 454
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 763-856 7.68e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.25  E-value: 7.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897691 763 RLEAHRRVHTGGKPYKCEV--CTKGFSESSRLQAHqRVHAEGRPYKCEQcgkgfsgySSLQAHHRVHTGEKPYKCEVCGK 840
Cdd:COG5189   336 DTPSRMLKVKDGKPYKCPVegCNKKYKNQNGLKYH-MLHGHQNQKLHEN--------PSPEKMNIFSAKDKPYRCEVCDK 406

                          90
                  ....*....|....*.
gi 1622897691 841 GFSQRSNLQAHqRVHT 856
Cdd:COG5189   407 RYKNLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
651-676 5.38e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 5.38e-04
                          10        20
                  ....*....|....*....|....*.
gi 1622897691 651 NLQIHQRVHTGEKPYKCEECGKGFSK 676
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
847-870 1.35e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.35e-03
                          10        20
                  ....*....|....*....|....
gi 1622897691 847 NLQAHQRVHTGEKPYKCDACGKGF 870
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 833-855 1.71e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.51  E-value: 1.71e-03
                          10        20
                  ....*....|....*....|...
gi 1622897691 833 YKCEVCGKGFSQRSNLQAHQRVH 855
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 607-659 6.74e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.38  E-value: 6.74e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1622897691 607 KPYkCEECGKGFSRSSHLQGHQRvhtgEKPFKCEECGKGFSWSFNLQIH-QRVH 659
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQK----AKHFKCHICHKKLYTAGGLAVHcLQVH 49
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
8-68 6.33e-26

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 101.13  E-value: 6.33e-26
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622897691    8 VTFKDVAVVFTEEELGLLDSVQRKLYRDVMLENFRNLLLVAHQPFKPDLISQLEREEKLLM 68
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 7-47 4.83e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 80.98  E-value: 4.83e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1622897691   7 MVTFKDVAVVFTEEELGLLDSVQRKLYRDVMLENFRNLLLV 47
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 8-44 4.10e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 69.89  E-value: 4.10e-15
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1622897691   8 VTFKDVAVVFTEEELGLLDSVQRKLYRDVMLENFRNL 44
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
365-756 4.46e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.18  E-value: 4.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897691 365 EKAFSHSLDLNSIFRVHTRDEPHE--YEENENVFNQSSCLQVHQKIHTEEKLYT--DVEYGKSFICSSNLDIQHRVHmee 440
Cdd:COG5048    40 TDSFSRLEHLTRHIRSHTGEKPSQcsYSGCDKSFSRPLELSRHLRTHHNNPSDLnsKSLPLSNSKASSSSLSSSSSN--- 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897691 441 NSYNSEECGNDFSLASHFQDLQIVHTKEQPYKRYVCGNSFSHNLYLQGHPKIHIGEKPHKDCGNGFNWSSKLkdHQRVHT 520
Cdd:COG5048   117 SNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLI--SSNVST 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897691 521 GQKPYKCNICGKGFNHRSVLNVHQRVHTGEKPYKCEECDKGFSRSSYLQAHQRVHTGEKPYKCEECGKGF--SRNSYLQG 598
Cdd:COG5048   195 SIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSlpTASSQSSS 274

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897691 599 HQRVHTGE-----KPYKCEECGKGFSRSSHLQGHQR--VHTGE--KPFKCEE--CGKGFSWSFNLQIHQRVHTGEKPYKC 667
Cdd:COG5048   275 PNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKE 354

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897691 668 --EECGKGFSKASTLLAHQRVH-----TGEKPYQCD--ECGKSFSQRSYLQSHQSVHSGERP--YICEVCGKGFSQRAYL 736
Cdd:COG5048   355 klLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNL 434

                         410       420
                  ....*....|....*....|
gi 1622897691 737 QGHQRVHTRVKPYKCEMCGK 756
Cdd:COG5048   435 IPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
250-627 4.00e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.63  E-value: 4.00e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897691 250 SIQTEEKPYPCTGY--RKAFNNDSSSEVHQQFHLKGKPYT-----YSSHGKGCSYSSLLHHHQNiQREDDIENSHLKSYQ 322
Cdd:COG5048    54 RSHTGEKPSQCSYSgcDKSFSRPLELSRHLRTHHNNPSDLnskslPLSNSKASSSSLSSSSSNS-NDNNLLSSHSLPPSS 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897691 323 RVHTEEKPCKCSEYGGNFNHYSPLNTYELIHTGEMSYRHNIYEKAFSHSLDL-NSIFRVHTRDEPHEYEENENVFNQS-- 399
Cdd:COG5048   133 RDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLsLLISSNVSTSIPSSSENSPLSSSYSip 212

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897691 400 SCLQVHQKIHTEEKLYTDVEYG---KSFICSSNLDIQHRVHMEENSYNSEECGND--FSLASHFQDLQIVHT-KEQPYKR 473
Cdd:COG5048   213 SSSSDQNLENSSSSLPLTTNSQlspKSLLSQSPSSLSSSDSSSSASESPRSSLPTasSQSSSPNESDSSSEKgFSLPIKS 292

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897691 474 YVCGNSFSHNLYLQGHP--KIHIGEK------PHKDCGNGFNWSSKLKDHQRVHTGQKPYKCNIC------GKGFNHRSV 539
Cdd:COG5048   293 KQCNISFSRSSPLTRHLrsVNHSGESlkpfscPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfSPLLNNEPP 372

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897691 540 LNVHQRVHTGEKPYKC---EECDKGFSRSSYLQAHQRVHTGEKP--YKCEECGKGFSRNSYLQGHQRVHTGEKPYKCEEC 614
Cdd:COG5048   373 QSLQQYKDLKNDKKSEtlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSIL 452

                         410
                  ....*....|...
gi 1622897691 615 GKgFSRSSHLQGH 627
Cdd:COG5048   453 KS-FRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
315-728 2.32e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 2.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897691 315 NSHLKSYQRVHTEEKPCKCSEYGGNFNHYSPLNtyelihtgemSYRHNIYEKAFSHSLDLNSIFRVHTRDEPHEYEeNEN 394
Cdd:COG5048    46 LEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLE----------LSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS-SSS 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897691 395 VFNQSSCLQVHQKIHTEEKLYTDveygkSFICSSNLDIQHRVHMEENSYNSEECGNDFSLashfqdlqIVHTKEQPYKRY 474
Cdd:COG5048   115 SNSNDNNLLSSHSLPPSSRDPQL-----PDLLSISNLRNNPLPGNNSSSVNTPQSNSLHP--------PLPANSLSKDPS 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897691 475 VCGNSFSHNLYLQGHPKIHIGEKPHKdcgngFNWSSKLKDHQRVHTGQKPYKCNICG----KGFNHRSVLNVHQRVHTGE 550
Cdd:COG5048   182 SNLSLLISSNVSTSIPSSSENSPLSS-----SYSIPSSSSDQNLENSSSSLPLTTNSqlspKSLLSQSPSSLSSSDSSSS 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897691 551 KPYKCEEC--DKGFSRSSYLQAHQRVHTG-EKPYKCEECGKGFSRNSYLQGHQR--VHTGE--KPYKCEE--CGKGFSRS 621
Cdd:COG5048   257 ASESPRSSlpTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRN 336

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897691 622 SHLQGHQRVHTGEKPFKC--EECGKGFSWSFN----LQIHQRVHTGEKPYKC---EECGKGFSKASTLLAHQRVHTGEKP 692
Cdd:COG5048   337 DALKRHILLHTSISPAKEklLNSSSKFSPLLNneppQSLQQYKDLKNDKKSEtlsNSCIRNFKRDSNLSLHIITHLSFRP 416

                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 1622897691 693 YQCD--ECGKSFSQRSYLQSHQSVHSGERPYICEVCGK 728
Cdd:COG5048   417 YNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
522-855 5.04e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.08  E-value: 5.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897691 522 QKPYKCNICGKGFNHRSVLNVHQRVHTGEKPYKC--EECDKGFSRSSYLQAHQRVHTGEKPYKCEecgkgfsrnsylQGH 599
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS------------KSL 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897691 600 QRVHTGEKPYKCEECGKGFSRSSHLQGHQRVHTGEKPFKCEEC------GKGFSWSFNLQIHQRVHTGEK-PYKCEECGK 672
Cdd:COG5048    99 PLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLsisnlrNNPLPGNNSSSVNTPQSNSLHpPLPANSLSK 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897691 673 GFSKASTLLAHQRVHTGEKPYQCDECGKSFSQRSYLQSHQSVHSGERPYICEVCGKGFSQRAYLQGHQRVHTRVKPYKCE 752
Cdd:COG5048   179 DPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSAS 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897691 753 MCG------KGFSQSSRLEAHRRVHTG-GKPYKCEVCTKGFSESSRLQAHQRVH----AEGRPYKC--EQCGKGFSGYSS 819
Cdd:COG5048   259 ESPrsslptASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSVnhsgESLKPFSCpySLCGKLFSRNDA 338

                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 1622897691 820 LQAHHRVHTGEKPYKC--EVCGKGFSQRSNLQAHQRVH 855
Cdd:COG5048   339 LKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQ 376
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 763-856 7.68e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.25  E-value: 7.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897691 763 RLEAHRRVHTGGKPYKCEV--CTKGFSESSRLQAHqRVHAEGRPYKCEQcgkgfsgySSLQAHHRVHTGEKPYKCEVCGK 840
Cdd:COG5189   336 DTPSRMLKVKDGKPYKCPVegCNKKYKNQNGLKYH-MLHGHQNQKLHEN--------PSPEKMNIFSAKDKPYRCEVCDK 406

                          90
                  ....*....|....*.
gi 1622897691 841 GFSQRSNLQAHqRVHT 856
Cdd:COG5189   407 RYKNLNGLKYH-RKHS 421
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
579-910 1.92e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.07  E-value: 1.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897691 579 KPYKCEECGKGFSRNSYLQGHQRVHTGEKPYKCEECGKGFSRS----------------SHLQGHQRVHTGEKPFKCEEC 642
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrplelsrhlrthhnnpSDLNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897691 643 GKGFSWSFNLQIHQRVHTGEKPY---------------KCEECGKGF--SKASTLLAHQ--RVHTGEKPYQCDECGKSFS 703
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDpqlpdllsisnlrnnPLPGNNSSSvnTPQSNSLHPPlpANSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897691 704 QRSYLQSHQSVHSGERPYICEVCGkgfsqraylqGHQRVHTRVKPYKCEMCGKGFSQSSRLEahRRVHTGGKPYKCEVCT 783
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSS----------SDQNLENSSSSLPLTTNSQLSPKSLLSQ--SPSSLSSSDSSSSASE 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897691 784 KGFSESSRLQAHQRVHAE---------GRPYKCEQCGKGFSGYSSLQAH--HRVHTGE--KPYKC--EVCGKGFSQRSNL 848
Cdd:COG5048   260 SPRSSLPTASSQSSSPNEsdsssekgfSLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCpySLCGKLFSRNDAL 339

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622897691 849 QAHQRVHTGEKPYKCDACGKGFrWSSGLLIHQRVHTSDKFYRSEDFGKDYPSSENLHRNEDS 910
Cdd:COG5048   340 KRHILLHTSISPAKEKLLNSSS-KFSPLLNNEPPQSLQQYKDLKNDKKSETLSNSCIRNFKR 400
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 499-632 3.61e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.94  E-value: 3.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897691 499 HKDCGNGfNWSSKLKDHQRVHTGQKPYKCNICGKGFNHRSVLNV----HQRVHTGEKPYKCE--ECDKGFSRSSYLQAHq 572
Cdd:COG5189   293 HKSVGNK-EIRGGISTGEMIDVRKLPCTNSSSNGKLAHGGERNIdtpsRMLKVKDGKPYKCPveGCNKKYKNQNGLKYH- 370

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897691 573 RVHTgekpykceECGKGFSRNSYLQGHQRVHTGEKPYKCEECGKGFSRSSHLQGHqRVHT 632
Cdd:COG5189   371 MLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
651-676 5.38e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 5.38e-04
                          10        20
                  ....*....|....*....|....*.
gi 1622897691 651 NLQIHQRVHTGEKPYKCEECGKGFSK 676
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
567-592 6.36e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 6.36e-04
                          10        20
                  ....*....|....*....|....*.
gi 1622897691 567 YLQAHQRVHTGEKPYKCEECGKGFSR 592
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
540-564 9.06e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 9.06e-04
                          10        20
                  ....*....|....*....|....*
gi 1622897691 540 LNVHQRVHTGEKPYKCEECDKGFSR 564
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
595-620 1.06e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 1.06e-03
                          10        20
                  ....*....|....*....|....*.
gi 1622897691 595 YLQGHQRVHTGEKPYKCEECGKGFSR 620
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
680-704 1.14e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.14e-03
                          10        20
                  ....*....|....*....|....*
gi 1622897691 680 LLAHQRVHTGEKPYQCDECGKSFSQ 704
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
512-536 1.28e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.28e-03
                          10        20
                  ....*....|....*....|....*
gi 1622897691 512 LKDHQRVHTGQKPYKCNICGKGFNH 536
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
847-870 1.35e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.35e-03
                          10        20
                  ....*....|....*....|....
gi 1622897691 847 NLQAHQRVHTGEKPYKCDACGKGF 870
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
623-647 1.60e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.60e-03
                          10        20
                  ....*....|....*....|....*
gi 1622897691 623 HLQGHQRVHTGEKPFKCEECGKGFS 647
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 833-855 1.71e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.51  E-value: 1.71e-03
                          10        20
                  ....*....|....*....|...
gi 1622897691 833 YKCEVCGKGFSQRSNLQAHQRVH 855
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
819-844 2.17e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.17e-03
                          10        20
                  ....*....|....*....|....*.
gi 1622897691 819 SLQAHHRVHTGEKPYKCEVCGKGFSQ 844
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 553-575 3.56e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 3.56e-03
                          10        20
                  ....*....|....*....|...
gi 1622897691 553 YKCEECDKGFSRSSYLQAHQRVH 575
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 609-631 3.85e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 3.85e-03
                          10        20
                  ....*....|....*....|...
gi 1622897691 609 YKCEECGKGFSRSSHLQGHQRVH 631
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 607-659 6.74e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.38  E-value: 6.74e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1622897691 607 KPYkCEECGKGFSRSSHLQGHQRvhtgEKPFKCEECGKGFSWSFNLQIH-QRVH 659
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQK----AKHFKCHICHKKLYTAGGLAVHcLQVH 49
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 693-715 7.59e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 7.59e-03
                          10        20
                  ....*....|....*....|...
gi 1622897691 693 YQCDECGKSFSQRSYLQSHQSVH 715
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 801-886 8.52e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 8.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622897691 801 EGRPYKCE--QCGKGFSGYSSLQaHHRVHTGEKPYKCEVCGKgfsqrsnlQAHQRVHTGEKPYKCDACGKGFRWSSGLLI 878
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLK-YHMLHGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*...
gi 1622897691 879 HqRVHTSD 886
Cdd:COG5189   417 H-RKHSHD 423
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 551-603 9.31e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.00  E-value: 9.31e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1622897691 551 KPYkCEECDKGFSRSSYLQAHQRvhtgEKPYKCEECGKGFSRNSYLQGH-QRVH 603
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQK----AKHFKCHICHKKLYTAGGLAVHcLQVH 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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