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Conserved domains on  [gi|967497283|ref|XP_014979037|]
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leucine-rich repeat LGI family member 4 isoform X3 [Macaca mulatta]

Protein Classification

LRR_8 and EPTP domain-containing protein( domain architecture ID 12158096)

LRR_8 and EPTP domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
82-173 2.51e-11

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 65.73  E-value: 2.51e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967497283  82 DLPVSFS--PNLLSLSFVRTGVTQLKAgSFLRIPSLHLLFIEDNEIGSISKnALRGLRSLTHLSLANNHLEALPRFLfRG 159
Cdd:COG4886  150 DLPEPLGnlTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLPEPL-AN 226

                         90
                 ....*....|....
gi 967497283 160 LETLTHVDLRGNPF 173
Cdd:COG4886  227 LTNLETLDLSNNQL 240
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 409-450 1.55e-08

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 50.54  E-value: 1.55e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 967497283  409 RFERRTDIPEAeDVYATRHFQAGGDVFLCLTRYIGDSMVMRW 450
Cdd:pfam03736   1 KFVPYQTIPTR-GARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 144-219 2.89e-08

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 57.01  E-value: 2.89e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 967497283   144 LANNHLEALPRFLFRGLETLTHVDLRGNPFQCDCRVLWLLQWMPTVNASV---GTGACAGPAALSHMQLRHLDPETFKC 219
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqpEAALCAGPGALAGQPLLGIPLLDSGC 80
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 364-405 3.20e-05

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 41.30  E-value: 3.20e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 967497283  364 GFYPHQSLHAWhRDTDAEALELDGRPHLLLASASQRPVLFHW 405
Cdd:pfam03736   1 KFVPYQTIPTR-GARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 227-263 1.45e-04

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 39.37  E-value: 1.45e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 967497283  227 FQTV-GESALSVEPFSYEGEPHIVLAqPFAGRCLILSW 263
Cdd:pfam03736   5 YQTIpTRGARDVEPFSIGGDLFLAVA-NFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 454-493 6.60e-04

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 37.45  E-value: 6.60e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 967497283  454 MFRLLQQLPSRGAHVFQPLLIARDQLAILGSDFAFSQVLR 493
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYR 40
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
82-173 2.51e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 65.73  E-value: 2.51e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967497283  82 DLPVSFS--PNLLSLSFVRTGVTQLKAgSFLRIPSLHLLFIEDNEIGSISKnALRGLRSLTHLSLANNHLEALPRFLfRG 159
Cdd:COG4886  150 DLPEPLGnlTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLPEPL-AN 226

                         90
                 ....*....|....
gi 967497283 160 LETLTHVDLRGNPF 173
Cdd:COG4886  227 LTNLETLDLSNNQL 240
LRR_8 pfam13855
Leucine rich repeat;
113-173 9.73e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.45  E-value: 9.73e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 967497283  113 PSLHLLFIEDNEIGSISKNALRGLRSLTHLSLANNHLEALPRFLFRGLETLTHVDLRGNPF 173
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 409-450 1.55e-08

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 50.54  E-value: 1.55e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 967497283  409 RFERRTDIPEAeDVYATRHFQAGGDVFLCLTRYIGDSMVMRW 450
Cdd:pfam03736   1 KFVPYQTIPTR-GARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 144-219 2.89e-08

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 57.01  E-value: 2.89e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 967497283   144 LANNHLEALPRFLFRGLETLTHVDLRGNPFQCDCRVLWLLQWMPTVNASV---GTGACAGPAALSHMQLRHLDPETFKC 219
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqpEAALCAGPGALAGQPLLGIPLLDSGC 80
LRRCT smart00082
Leucine rich repeat C-terminal domain;
171-219 3.47e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 47.04  E-value: 3.47e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 967497283   171 NPFQCDCRVLWLLQWMPTVNASVGTGA--CAGPAALsHMQLRHLDPETFKC 219
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDlrCASPSSL-RGPLLELLHSEFKC 50
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 113-173 3.49e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 48.24  E-value: 3.49e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 967497283 113 PSLHLLFIEDNEIGSISKnaLRGLRSLTHLSLANNHLEALPRF--LFRGLETLTHVDLRGNPF 173
Cdd:cd21340  120 NSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEELldLLSSWPSLRELDLTGNPV 180
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 364-405 3.20e-05

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 41.30  E-value: 3.20e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 967497283  364 GFYPHQSLHAWhRDTDAEALELDGRPHLLLASASQRPVLFHW 405
Cdd:pfam03736   1 KFVPYQTIPTR-GARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 227-263 1.45e-04

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 39.37  E-value: 1.45e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 967497283  227 FQTV-GESALSVEPFSYEGEPHIVLAqPFAGRCLILSW 263
Cdd:pfam03736   5 YQTIpTRGARDVEPFSIGGDLFLAVA-NFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 454-493 6.60e-04

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 37.45  E-value: 6.60e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 967497283  454 MFRLLQQLPSRGAHVFQPLLIARDQLAILGSDFAFSQVLR 493
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYR 40
LRR smart00370
Leucine-rich repeats, outliers;
136-159 2.50e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.41  E-value: 2.50e-03
                           10        20
                   ....*....|....*....|....
gi 967497283   136 LRSLTHLSLANNHLEALPRFLFRG 159
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
82-173 2.51e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 65.73  E-value: 2.51e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967497283  82 DLPVSFS--PNLLSLSFVRTGVTQLKAgSFLRIPSLHLLFIEDNEIGSISKnALRGLRSLTHLSLANNHLEALPRFLfRG 159
Cdd:COG4886  150 DLPEPLGnlTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLPEPL-AN 226

                         90
                 ....*....|....
gi 967497283 160 LETLTHVDLRGNPF 173
Cdd:COG4886  227 LTNLETLDLSNNQL 240
LRR_8 pfam13855
Leucine rich repeat;
113-173 9.73e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.45  E-value: 9.73e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 967497283  113 PSLHLLFIEDNEIGSISKNALRGLRSLTHLSLANNHLEALPRFLFRGLETLTHVDLRGNPF 173
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
82-173 6.32e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 58.02  E-value: 6.32e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967497283  82 DLPVSFS--PNLLSLSFVRTGVTQLKAgSFLRIPSLHLLFIEDNEIGSISknALRGLRSLTHLSLANNHLEALPRFLfrG 159
Cdd:COG4886  196 DLPEPLGnlTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--N 270

                         90
                 ....*....|....
gi 967497283 160 LETLTHVDLRGNPF 173
Cdd:COG4886  271 LTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
82-173 1.27e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 57.25  E-value: 1.27e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967497283  82 DLPVSFS--PNLLSLSFVRTGVTQLKAgSFLRIPSLHLLFIEDNEIGSISKnALRGLRSLTHLSLANNHLEALPRFLfrG 159
Cdd:COG4886  173 DLPEELGnlTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLPELG--N 248

                         90
                 ....*....|....
gi 967497283 160 LETLTHVDLRGNPF 173
Cdd:COG4886  249 LTNLEELDLSNNQL 262
LRR_8 pfam13855
Leucine rich repeat;
89-149 1.31e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.37  E-value: 1.31e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 967497283   89 PNLLSLSFVRTGVTQLKAGSFLRIPSLHLLFIEDNEIGSISKNALRGLRSLTHLSLANNHL 149
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 409-450 1.55e-08

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 50.54  E-value: 1.55e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 967497283  409 RFERRTDIPEAeDVYATRHFQAGGDVFLCLTRYIGDSMVMRW 450
Cdd:pfam03736   1 KFVPYQTIPTR-GARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 144-219 2.89e-08

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 57.01  E-value: 2.89e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 967497283   144 LANNHLEALPRFLFRGLETLTHVDLRGNPFQCDCRVLWLLQWMPTVNASV---GTGACAGPAALSHMQLRHLDPETFKC 219
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqpEAALCAGPGALAGQPLLGIPLLDSGC 80
LRRCT smart00082
Leucine rich repeat C-terminal domain;
171-219 3.47e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 47.04  E-value: 3.47e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 967497283   171 NPFQCDCRVLWLLQWMPTVNASVGTGA--CAGPAALsHMQLRHLDPETFKC 219
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDlrCASPSSL-RGPLLELLHSEFKC 50
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 113-173 3.49e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 48.24  E-value: 3.49e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 967497283 113 PSLHLLFIEDNEIGSISKnaLRGLRSLTHLSLANNHLEALPRF--LFRGLETLTHVDLRGNPF 173
Cdd:cd21340  120 NSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEELldLLSSWPSLRELDLTGNPV 180
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
109-171 1.56e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 47.62  E-value: 1.56e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 967497283 109 FLRIPSLHLLFIEDNEIGSISKnALRGLRSLTHLSLANNHLEALPRFLFrGLETLTHVDLRGN 171
Cdd:COG4886  109 LSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEPLG-NLTNLKSLDLSNN 169
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 364-405 3.20e-05

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 41.30  E-value: 3.20e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 967497283  364 GFYPHQSLHAWhRDTDAEALELDGRPHLLLASASQRPVLFHW 405
Cdd:pfam03736   1 KFVPYQTIPTR-GARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 227-263 1.45e-04

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 39.37  E-value: 1.45e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 967497283  227 FQTV-GESALSVEPFSYEGEPHIVLAqPFAGRCLILSW 263
Cdd:pfam03736   5 YQTIpTRGARDVEPFSIGGDLFLAVA-NFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 454-493 6.60e-04

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 37.45  E-value: 6.60e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 967497283  454 MFRLLQQLPSRGAHVFQPLLIARDQLAILGSDFAFSQVLR 493
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYR 40
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
90-173 9.29e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.84  E-value: 9.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967497283  90 NLLSLSFVRTGVTQLKAGSFLRIPSLHLLFIEDNeigsiskNALRGLRSLTHLSLANNHLEALPRFLFRgLETLTHVDLR 169
Cdd:COG4886   73 LLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEELAN-LTNLKELDLS 144


                 ....
gi 967497283 170 GNPF 173
Cdd:COG4886  145 NNQL 148
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 138-180 1.11e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.84  E-value: 1.11e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 967497283  138 SLTHLSLANNHLEALPrfLFRGLETLTHVDLRGNPFQCDCRVL 180
Cdd:pfam12799   2 NLEVLDLSNNQITDIP--PLAKLPNLETLDLSGNNKITDLSDL 42
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
82-152 1.83e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 40.69  E-value: 1.83e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 967497283  82 DLPVSFS--PNLLSLSFVRTGVTQLKagSFLRIPSLHLLFIEDNEIGSISKNAlrGLRSLTHLSLANNHLEAL 152
Cdd:COG4886  219 DLPEPLAnlTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDL 287
LRR smart00370
Leucine-rich repeats, outliers;
136-159 2.50e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.41  E-value: 2.50e-03
                           10        20
                   ....*....|....*....|....
gi 967497283   136 LRSLTHLSLANNHLEALPRFLFRG 159
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
136-159 2.50e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 35.41  E-value: 2.50e-03
                           10        20
                   ....*....|....*....|....
gi 967497283   136 LRSLTHLSLANNHLEALPRFLFRG 159
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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