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Conserved domains on  [gi|1622896444|ref|XP_014979023|]
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zinc finger protein 30 isoform X3 [Macaca mulatta]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
8-67 3.26e-28

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 107.29  E-value: 3.26e-28
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896444    8 VTFEDVAIAFSQQEWESLDSSQRGLYRDVMLENYRNLVSMaGHSLSKPHVIALLERWKEP 67
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSL-GFQVPKPDLISQLEQGEEP 59
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
253-611 2.16e-15

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 78.97  E-value: 2.16e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896444 253 KPFVCEECGKAFSTFSYLIQHQRIHTGEKPYEC--KECGKAFSTSSPLAKHQRIHTGEKPYECK---------------- 314
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsnskassssls 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896444 315 ECGKAFTV--------YGQLTRHQSIHTGEKPFE--------CKECGKAFRLSSFLHA-------------------HQR 359
Cdd:COG5048   112 SSSSNSNDnnllsshsLPPSSRDPQLPDLLSISNlrnnplpgNNSSSVNTPQSNSLHPplpanslskdpssnlslliSSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896444 360 IHAGIKPYGCKECGKTFSRASYLVQHGRLHTGEKPYECKECGKAFSTGSYLVQHQRIHTGEKPHECKECG------KAFI 433
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPrsslptASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896444 434 SRHQLTVHQRVHTG-EKPYECKECGKAFRVHVHLTQHR--KIHT--DVKPYECKE--CGKTFSRASYLVQHGRIHTGKKP 506
Cdd:COG5048   272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSgeSLKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896444 507 YECK--ECGKAFSSGSY-----LVQHQRIHTGEKPYEC--NKCGKAFTVYGQLIGHQSVHTGEKP--FECKECGKAFRLN 575
Cdd:COG5048   352 AKEKllNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRH 431

                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 1622896444 576 SFLTEHQRVHTGEKPFKCKICGKtFRYSSALKVHLR 611
Cdd:COG5048   432 YNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
94-296 9.54e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 9.54e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896444  94 MLPSENCPSFAPHQKISRQKPRECREYGKTLCQDSKPVQH--ERIHSSEKPNRCKECGKNFSNGHQLTIHQRLYVDE--- 168
Cdd:COG5048   239 SLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESdsSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSVNHSges 318

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896444 169 -KPYKC--EKCGKAFIRGSAFVKHRRIHTGEKSLKCK--RCEKTFSG-----NYQLTVHESIHTGKKPYEC--GECGKAF 236
Cdd:COG5048   319 lKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPllnnePPQSLQQYKDLKNDKKSETlsNSCIRNF 398

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622896444 237 LAYGKLTRHQSIHTGEKPFVCE--ECGKAFSTFSYLIQHQRIHTGEKPYECKECGKAFSTSS 296
Cdd:COG5048   399 KRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
8-67 3.26e-28

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 107.29  E-value: 3.26e-28
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896444    8 VTFEDVAIAFSQQEWESLDSSQRGLYRDVMLENYRNLVSMaGHSLSKPHVIALLERWKEP 67
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSL-GFQVPKPDLISQLEQGEEP 59
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 7-47 4.06e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 89.07  E-value: 4.06e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1622896444   7 SVTFEDVAIAFSQQEWESLDSSQRGLYRDVMLENYRNLVSM 47
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 8-47 3.79e-21

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 86.45  E-value: 3.79e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1622896444   8 VTFEDVAIAFSQQEWESLDSSQRGLYRDVMLENYRNLVSM 47
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
253-611 2.16e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 78.97  E-value: 2.16e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896444 253 KPFVCEECGKAFSTFSYLIQHQRIHTGEKPYEC--KECGKAFSTSSPLAKHQRIHTGEKPYECK---------------- 314
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsnskassssls 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896444 315 ECGKAFTV--------YGQLTRHQSIHTGEKPFE--------CKECGKAFRLSSFLHA-------------------HQR 359
Cdd:COG5048   112 SSSSNSNDnnllsshsLPPSSRDPQLPDLLSISNlrnnplpgNNSSSVNTPQSNSLHPplpanslskdpssnlslliSSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896444 360 IHAGIKPYGCKECGKTFSRASYLVQHGRLHTGEKPYECKECGKAFSTGSYLVQHQRIHTGEKPHECKECG------KAFI 433
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPrsslptASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896444 434 SRHQLTVHQRVHTG-EKPYECKECGKAFRVHVHLTQHR--KIHT--DVKPYECKE--CGKTFSRASYLVQHGRIHTGKKP 506
Cdd:COG5048   272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSgeSLKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896444 507 YECK--ECGKAFSSGSY-----LVQHQRIHTGEKPYEC--NKCGKAFTVYGQLIGHQSVHTGEKP--FECKECGKAFRLN 575
Cdd:COG5048   352 AKEKllNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRH 431

                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 1622896444 576 SFLTEHQRVHTGEKPFKCKICGKtFRYSSALKVHLR 611
Cdd:COG5048   432 YNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
94-296 9.54e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 9.54e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896444  94 MLPSENCPSFAPHQKISRQKPRECREYGKTLCQDSKPVQH--ERIHSSEKPNRCKECGKNFSNGHQLTIHQRLYVDE--- 168
Cdd:COG5048   239 SLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESdsSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSVNHSges 318

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896444 169 -KPYKC--EKCGKAFIRGSAFVKHRRIHTGEKSLKCK--RCEKTFSG-----NYQLTVHESIHTGKKPYEC--GECGKAF 236
Cdd:COG5048   319 lKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPllnnePPQSLQQYKDLKNDKKSETlsNSCIRNF 398

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622896444 237 LAYGKLTRHQSIHTGEKPFVCE--ECGKAFSTFSYLIQHQRIHTGEKPYECKECGKAFSTSS 296
Cdd:COG5048   399 KRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
zf-H2C2_2 pfam13465
Zinc-finger double domain;
269-294 3.20e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.20e-04
                          10        20
                  ....*....|....*....|....*.
gi 1622896444 269 YLIQHQRIHTGEKPYECKECGKAFST 294
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 253-305 3.51e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.46  E-value: 3.51e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1622896444 253 KPFvCEECGKAFSTFSYLIQHQRIHTgekpYECKECGKAFSTSSPLAKH-QRIH 305
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
8-67 3.26e-28

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 107.29  E-value: 3.26e-28
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896444    8 VTFEDVAIAFSQQEWESLDSSQRGLYRDVMLENYRNLVSMaGHSLSKPHVIALLERWKEP 67
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSL-GFQVPKPDLISQLEQGEEP 59
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 7-47 4.06e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 89.07  E-value: 4.06e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1622896444   7 SVTFEDVAIAFSQQEWESLDSSQRGLYRDVMLENYRNLVSM 47
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 8-47 3.79e-21

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 86.45  E-value: 3.79e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1622896444   8 VTFEDVAIAFSQQEWESLDSSQRGLYRDVMLENYRNLVSM 47
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
253-611 2.16e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 78.97  E-value: 2.16e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896444 253 KPFVCEECGKAFSTFSYLIQHQRIHTGEKPYEC--KECGKAFSTSSPLAKHQRIHTGEKPYECK---------------- 314
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsnskassssls 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896444 315 ECGKAFTV--------YGQLTRHQSIHTGEKPFE--------CKECGKAFRLSSFLHA-------------------HQR 359
Cdd:COG5048   112 SSSSNSNDnnllsshsLPPSSRDPQLPDLLSISNlrnnplpgNNSSSVNTPQSNSLHPplpanslskdpssnlslliSSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896444 360 IHAGIKPYGCKECGKTFSRASYLVQHGRLHTGEKPYECKECGKAFSTGSYLVQHQRIHTGEKPHECKECG------KAFI 433
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPrsslptASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896444 434 SRHQLTVHQRVHTG-EKPYECKECGKAFRVHVHLTQHR--KIHT--DVKPYECKE--CGKTFSRASYLVQHGRIHTGKKP 506
Cdd:COG5048   272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSgeSLKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896444 507 YECK--ECGKAFSSGSY-----LVQHQRIHTGEKPYEC--NKCGKAFTVYGQLIGHQSVHTGEKP--FECKECGKAFRLN 575
Cdd:COG5048   352 AKEKllNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRH 431

                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 1622896444 576 SFLTEHQRVHTGEKPFKCKICGKtFRYSSALKVHLR 611
Cdd:COG5048   432 YNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
281-613 1.85e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.64  E-value: 1.85e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896444 281 KPYECKECGKAFSTSSPLAKHQRIHTGEKPYEC--KECGKAFTVYGQLTRHQSIHTGEKPFECKecgKAFRLSSFLHAHQ 358
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS---KSLPLSNSKASSS 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896444 359 RIHAGI----KPYGCKECGKTFSRASYLVQHGRLHTGEKPYECKEC-----------------------GKAFSTGSYLV 411
Cdd:COG5048   109 SLSSSSsnsnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslsKDPSSNLSLLI 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896444 412 QHQRIHTGEKPHECKECGKAFISRHQLTVHQRVH-----------------------TGEKPY----ECKECGKAFRVHV 464
Cdd:COG5048   189 SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENsssslplttnsqlspksllsqspSSLSSSdsssSASESPRSSLPTA 268

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896444 465 HLTQHRKIHTDV-------KPYECKECGKTFSRASYLVQH--GRIHTGK--KPYECKE--CGKAFSSGSYLVQHQRIHTG 531
Cdd:COG5048   269 SSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896444 532 EKPYEC--NKCGKAFTV-----YGQLIGHQSVHTGEKPFEC--KECGKAFRLNSFLTEHQRVHTGEKP--FKCKICGKTF 600
Cdd:COG5048   349 ISPAKEklLNSSSKFSPllnnePPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSF 428

                         410
                  ....*....|...
gi 1622896444 601 RYSSALKVHLRKH 613
Cdd:COG5048   429 NRHYNLIPHKKIH 441
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
94-296 9.54e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 9.54e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896444  94 MLPSENCPSFAPHQKISRQKPRECREYGKTLCQDSKPVQH--ERIHSSEKPNRCKECGKNFSNGHQLTIHQRLYVDE--- 168
Cdd:COG5048   239 SLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESdsSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSVNHSges 318

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896444 169 -KPYKC--EKCGKAFIRGSAFVKHRRIHTGEKSLKCK--RCEKTFSG-----NYQLTVHESIHTGKKPYEC--GECGKAF 236
Cdd:COG5048   319 lKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPllnnePPQSLQQYKDLKNDKKSETlsNSCIRNF 398

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622896444 237 LAYGKLTRHQSIHTGEKPFVCE--ECGKAFSTFSYLIQHQRIHTGEKPYECKECGKAFSTSS 296
Cdd:COG5048   399 KRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
365-618 4.28e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 4.28e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896444 365 KPYGCKECGKTFSRASYLVQHGRLHTGEKPYEC--KECGKAFSTGSYLVQHQRIHTGEKPHECKecgKAFISRHQLTVHQ 442
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS---KSLPLSNSKASSS 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896444 443 --RVHTGEKPYECKECGKAFRVHVHLTQHRKIHTDVKPYECKE-------------------------CGKTFSRASYLV 495
Cdd:COG5048   109 slSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLpgnnsssvntpqsnslhpplpanslSKDPSSNLSLLI 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896444 496 QHGRIHTGKKPYECKECG---KAFSSGSYLV---------QHQRIHTGEKPY---------------ECNKCGKAFTVYG 548
Cdd:COG5048   189 SSNVSTSIPSSSENSPLSssySIPSSSSDQNlensssslpLTTNSQLSPKSLlsqspsslsssdsssSASESPRSSLPTA 268

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896444 549 QLIGHQSVHTGE-------KPFECKECGKAFRLNSFLTEHQR--VHTGE--KPFKC--KICGKTFRYSSALKVHLRKHMG 615
Cdd:COG5048   269 SSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTS 348


                  ...
gi 1622896444 616 VIP 618
Cdd:COG5048   349 ISP 351
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 531-613 1.04e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 48.18  E-value: 1.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896444 531 GEKPYECN--KCGKAFT-----VYGQLIGHQSVHTGEKPFECKecgkafrLNSFLTEhqrvhtgEKPFKCKICGKTFRYS 603
Cdd:COG5189   346 DGKPYKCPveGCNKKYKnqnglKYHMLHGHQNQKLHENPSPEK-------MNIFSAK-------DKPYRCEVCDKRYKNL 411

                          90
                  ....*....|
gi 1622896444 604 SALKVHlRKH 613
Cdd:COG5189   412 NGLKYH-RKH 420
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
475-542 2.21e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.38  E-value: 2.21e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896444 475 DVKPYECKECGKTFSRASYLVQHGRIHTGKKPYEC--KECGKAFSSGSYLVQHQRIHTGEKPYECNKCGK 542
Cdd:COG5048    30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP 99
zf-H2C2_2 pfam13465
Zinc-finger double domain;
269-294 3.20e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.20e-04
                          10        20
                  ....*....|....*....|....*.
gi 1622896444 269 YLIQHQRIHTGEKPYECKECGKAFST 294
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 253-305 3.51e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.46  E-value: 3.51e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1622896444 253 KPFvCEECGKAFSTFSYLIQHQRIHTgekpYECKECGKAFSTSSPLAKH-QRIH 305
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
zf-H2C2_2 pfam13465
Zinc-finger double domain;
409-434 4.42e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.42e-04
                          10        20
                  ....*....|....*....|....*.
gi 1622896444 409 YLVQHQRIHTGEKPHECKECGKAFIS 434
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
298-321 5.93e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.93e-04
                          10        20
                  ....*....|....*....|....
gi 1622896444 298 LAKHQRIHTGEKPYECKECGKAFT 321
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
521-545 8.45e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 8.45e-04
                          10        20
                  ....*....|....*....|....*
gi 1622896444 521 YLVQHQRIHTGEKPYECNKCGKAFT 545
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 561-610 1.84e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.54  E-value: 1.84e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1622896444 561 KPFeCKECGKAFRLNSFLTEHQRvhtgEKPFKCKICGKTFRYSSALKVHL 610
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQK----AKHFKCHICHKKLYTAGGLAVHC 45
zf-H2C2_2 pfam13465
Zinc-finger double domain;
578-602 2.61e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.61e-03
                          10        20
                  ....*....|....*....|....*
gi 1622896444 578 LTEHQRVHTGEKPFKCKICGKTFRY 602
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 591-613 3.17e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 3.17e-03
                          10        20
                  ....*....|....*....|...
gi 1622896444 591 FKCKICGKTFRYSSALKVHLRKH 613
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
438-460 3.87e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.87e-03
                          10        20
                  ....*....|....*....|...
gi 1622896444 438 LTVHQRVHTGEKPYECKECGKAF 460
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
326-348 4.15e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.15e-03
                          10        20
                  ....*....|....*....|...
gi 1622896444 326 LTRHQSIHTGEKPFECKECGKAF 348
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
242-266 4.19e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.19e-03
                          10        20
                  ....*....|....*....|....*
gi 1622896444 242 LTRHQSIHTGEKPFVCEECGKAFST 266
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
493-518 5.85e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.85e-03
                          10        20
                  ....*....|....*....|....*.
gi 1622896444 493 YLVQHGRIHTGKKPYECKECGKAFSS 518
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
465-490 6.78e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 6.78e-03
                          10        20
                  ....*....|....*....|....*.
gi 1622896444 465 HLTQHRKIHTDVKPYECKECGKTFSR 490
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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