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Conserved domains on  [gi|1622898790|ref|XP_014978904|]
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zinc finger protein 682 [Macaca mulatta]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-64 4.45e-32

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 116.92  E-value: 4.45e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622898790    4 LTFRDVTIEFSLEEWEFLKPAQQNLYRKVMLENYRNLVSLGLTVSKPELISCLEQRQEPWN 64
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
239-445 1.17e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.40  E-value: 1.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622898790 239 NWCSTLTKHKRIHTgekPYRCEECGKAFHWCSPFVRHK--KIHTGE--KPYTCEE--CGRAFNRHSHLTKHKTIHTGKKP 312
Cdd:COG5048   275 PNESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622898790 313 YKCKecgkafnhcslLTVHERTHTGEKPYKCEECgkafnsssilTEHKVIHSGEKPYKCE--KCDKVFKRFSYLTKHKRI 390
Cdd:COG5048   352 AKEK-----------LLNSSSKFSPLLNNEPPQS----------LQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIIT 410

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622898790 391 HTGEKP--YKCEECGKAFNWSSILTEHKRIHTGEKPYNCEECGKaFNRCSHLTRHKK 445
Cdd:COG5048   411 HLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
215-239 4.95e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.95e-04
                          10        20
                  ....*....|....*....|....*
gi 1622898790 215 YLTKHKRIHTGEKPYKCEECGKAFN 239
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 super family cl34881
FOG: Zn-finger [General function prediction only];
130-277 4.11e-03

FOG: Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5048:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.68  E-value: 4.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622898790 130 YNGLNQCLSTLPSKIFPYNKCVKVFSKSSSLKRQSIRHTTEKLFKCV--QCGKVFKS-----HSGLSYHKIIHTEEKLYI 202
Cdd:COG5048   309 LRSVNHSGESLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPllnnePPQSLQQYKDLKNDKKSE 388

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622898790 203 CE--ECGKTFKWFSYLTKHKRIHTGEKP--YKCEECGKAFNWCSTLTKHKRIHTGEKPYRCEECGKaFHWCSPFVRHKK 277
Cdd:COG5048   389 TLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
439-464 4.59e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.59e-03
                          10        20
                  ....*....|....*....|....*.
gi 1622898790 439 HLTRHKKIHTAIKHYKCEECGKAFKR 464
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-64 4.45e-32

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 116.92  E-value: 4.45e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622898790    4 LTFRDVTIEFSLEEWEFLKPAQQNLYRKVMLENYRNLVSLGLTVSKPELISCLEQRQEPWN 64
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 4.35e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 85.99  E-value: 4.35e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1622898790   3 LLTFRDVTIEFSLEEWEFLKPAQQNLYRKVMLENYRNLVSLG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-43 4.46e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 74.51  E-value: 4.46e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1622898790   4 LTFRDVTIEFSLEEWEFLKPAQQNLYRKVMLENYRNLVSL 43
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
239-445 1.17e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.40  E-value: 1.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622898790 239 NWCSTLTKHKRIHTgekPYRCEECGKAFHWCSPFVRHK--KIHTGE--KPYTCEE--CGRAFNRHSHLTKHKTIHTGKKP 312
Cdd:COG5048   275 PNESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622898790 313 YKCKecgkafnhcslLTVHERTHTGEKPYKCEECgkafnsssilTEHKVIHSGEKPYKCE--KCDKVFKRFSYLTKHKRI 390
Cdd:COG5048   352 AKEK-----------LLNSSSKFSPLLNNEPPQS----------LQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIIT 410

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622898790 391 HTGEKP--YKCEECGKAFNWSSILTEHKRIHTGEKPYNCEECGKaFNRCSHLTRHKK 445
Cdd:COG5048   411 HLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
215-239 4.95e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.95e-04
                          10        20
                  ....*....|....*....|....*
gi 1622898790 215 YLTKHKRIHTGEKPYKCEECGKAFN 239
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
383-407 4.95e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.95e-04
                          10        20
                  ....*....|....*....|....*
gi 1622898790 383 YLTKHKRIHTGEKPYKCEECGKAFN 407
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
130-277 4.11e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.68  E-value: 4.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622898790 130 YNGLNQCLSTLPSKIFPYNKCVKVFSKSSSLKRQSIRHTTEKLFKCV--QCGKVFKS-----HSGLSYHKIIHTEEKLYI 202
Cdd:COG5048   309 LRSVNHSGESLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPllnnePPQSLQQYKDLKNDKKSE 388

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622898790 203 CE--ECGKTFKWFSYLTKHKRIHTGEKP--YKCEECGKAFNWCSTLTKHKRIHTGEKPYRCEECGKaFHWCSPFVRHKK 277
Cdd:COG5048   389 TLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
439-464 4.59e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.59e-03
                          10        20
                  ....*....|....*....|....*.
gi 1622898790 439 HLTRHKKIHTAIKHYKCEECGKAFKR 464
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-64 4.45e-32

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 116.92  E-value: 4.45e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622898790    4 LTFRDVTIEFSLEEWEFLKPAQQNLYRKVMLENYRNLVSLGLTVSKPELISCLEQRQEPWN 64
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 4.35e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 85.99  E-value: 4.35e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1622898790   3 LLTFRDVTIEFSLEEWEFLKPAQQNLYRKVMLENYRNLVSLG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-43 4.46e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 74.51  E-value: 4.46e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1622898790   4 LTFRDVTIEFSLEEWEFLKPAQQNLYRKVMLENYRNLVSL 43
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
239-445 1.17e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.40  E-value: 1.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622898790 239 NWCSTLTKHKRIHTgekPYRCEECGKAFHWCSPFVRHK--KIHTGE--KPYTCEE--CGRAFNRHSHLTKHKTIHTGKKP 312
Cdd:COG5048   275 PNESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622898790 313 YKCKecgkafnhcslLTVHERTHTGEKPYKCEECgkafnsssilTEHKVIHSGEKPYKCE--KCDKVFKRFSYLTKHKRI 390
Cdd:COG5048   352 AKEK-----------LLNSSSKFSPLLNNEPPQS----------LQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIIT 410

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622898790 391 HTGEKP--YKCEECGKAFNWSSILTEHKRIHTGEKPYNCEECGKaFNRCSHLTRHKK 445
Cdd:COG5048   411 HLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
292-474 3.83e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.47  E-value: 3.83e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622898790 292 RAFNRHSHLTKHKTIHTGK-KPYKCKECGKAFNHCSLLTVHERT--HTGE--KPYKCEE--CGKAFNSSSILTEHKVIHS 364
Cdd:COG5048   268 ASSQSSSPNESDSSSEKGFsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHT 347

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622898790 365 GEKPYKC--EKCDKVF------KRFSYLTKHKRIHTGEKPYKCEECGKAFNWS-SILTEHKRIHTGEKPYNCE--ECGKA 433
Cdd:COG5048   348 SISPAKEklLNSSSKFspllnnEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRdSNLSLHIITHLSFRPYNCKnpPCSKS 427

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1622898790 434 FNRCSHLTRHKKIHTAIKHYKCEECGKaFKRCSHLNEHKRV 474
Cdd:COG5048   428 FNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
199-485 2.40e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.16  E-value: 2.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622898790 199 KLYICEECGKTFKWFSYLTKHKRIHTGEKPYKC--EECGKAFNWCSTLTKHKRIHTGEKPYRCE-ECGKAFHWCSPFVRH 275
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622898790 276 KKIHTGEKPYTCEECGRAFNRHS---HLTKHKTIHTGKKPYKCKECGKAFNHCSLL-------------------TVHER 333
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDpqlPDLLSISNLRNNPLPGNNSSSVNTPQSNSLhpplpanslskdpssnlslLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622898790 334 THTGEKPYKCEECGKAFNSSSILTEHKVIHSGEKPYKCEKCDKVF------------------------------KRFSY 383
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsqspsslsssdssssasesprsslpTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622898790 384 LTKHKRIHTGE-----KPYKCEECGKAFNWSSILTEHKR--IHTGE--KPYNCEE--CGKAFNRCSHLTRHKKIHTAIKH 452
Cdd:COG5048   272 SSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1622898790 453 YKC--EECGKAFKRCSHLNEHKRVQRREKSCKYKK 485
Cdd:COG5048   352 AKEklLNSSSKFSPLLNNEPPQSLQQYKDLKNDKK 386
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 310-392 4.61e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 4.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622898790 310 KKPYKCKECGKAFNHCSLLTVHERTH----TGEKPYKCE--ECGKAFNSSSILTEHK-------------------VIHS 364
Cdd:COG5189   315 KLPCTNSSSNGKLAHGGERNIDTPSRmlkvKDGKPYKCPveGCNKKYKNQNGLKYHMlhghqnqklhenpspekmnIFSA 394

                          90       100
                  ....*....|....*....|....*...
gi 1622898790 365 GEKPYKCEKCDKVFKRFSYLtKHKRIHT 392
Cdd:COG5189   395 KDKPYRCEVCDKRYKNLNGL-KYHRKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
215-239 4.95e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.95e-04
                          10        20
                  ....*....|....*....|....*
gi 1622898790 215 YLTKHKRIHTGEKPYKCEECGKAFN 239
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
383-407 4.95e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.95e-04
                          10        20
                  ....*....|....*....|....*
gi 1622898790 383 YLTKHKRIHTGEKPYKCEECGKAFN 407
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
328-352 8.24e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 8.24e-04
                          10        20
                  ....*....|....*....|....*
gi 1622898790 328 LTVHERTHTGEKPYKCEECGKAFNS 352
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
299-324 1.22e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.22e-03
                          10        20
                  ....*....|....*....|....*.
gi 1622898790 299 HLTKHKTIHTGKKPYKCKECGKAFNH 324
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
412-436 1.27e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.27e-03
                          10        20
                  ....*....|....*....|....*
gi 1622898790 412 LTEHKRIHTGEKPYNCEECGKAFNR 436
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
244-266 1.47e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.47e-03
                          10        20
                  ....*....|....*....|...
gi 1622898790 244 LTKHKRIHTGEKPYRCEECGKAF 266
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 365-445 1.63e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 1.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622898790 365 GEKPYKCE--KCDKVFKRFSYLtKHKRIHTGEKPYKCEecgkafNWSSIltEHKRIHTGEKPYNCEECGKAFNRCSHLTR 442
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGL-KYHMLHGHQNQKLHE------NPSPE--KMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ...
gi 1622898790 443 HKK 445
Cdd:COG5189   417 HRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
274-296 3.78e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.78e-03
                          10        20
                  ....*....|....*....|...
gi 1622898790 274 RHKKIHTGEKPYTCEECGRAFNR 296
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
130-277 4.11e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.68  E-value: 4.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622898790 130 YNGLNQCLSTLPSKIFPYNKCVKVFSKSSSLKRQSIRHTTEKLFKCV--QCGKVFKS-----HSGLSYHKIIHTEEKLYI 202
Cdd:COG5048   309 LRSVNHSGESLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPllnnePPQSLQQYKDLKNDKKSE 388

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622898790 203 CE--ECGKTFKWFSYLTKHKRIHTGEKP--YKCEECGKAFNWCSTLTKHKRIHTGEKPYRCEECGKaFHWCSPFVRHKK 277
Cdd:COG5048   389 TLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
439-464 4.59e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.59e-03
                          10        20
                  ....*....|....*....|....*.
gi 1622898790 439 HLTRHKKIHTAIKHYKCEECGKAFKR 464
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
310-374 7.09e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.91  E-value: 7.09e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622898790 310 KKPYKCKECGKAFNHCSLLTVHERTHTGEKPYKC--EECGKAFNSSSILTEHKVIHSGEKPYKCEKC 374
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKS 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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