NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1622890935|ref|XP_014978566|]
View 

prostaglandin E2 receptor EP1 subtype isoform X1 [Macaca mulatta]

Protein Classification

G protein-coupled receptor family protein; olfactory receptor subfamily 2A protein( domain architecture ID 11606870)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters| olfactory receptor (OR) subfamily 2A protein, such as human olfactory receptor 2A2 and related proteins in other mammals and sauropsids; ORs play a central role in olfaction, the sense of smell, and belong to the class A rhodopsin-like family of seven-transmembrane G protein-coupled receptors (7TM GPCRs)

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
7tmA_PGE2_EP1 cd15144
prostaglandin E2 receptor EP1 subtype, member of the class A family of seven-transmembrane G ...
33-363 4.20e-114

prostaglandin E2 receptor EP1 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP1, also called prostanoid EP1 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. It has been shown that stimulation of the EP1 receptor by PGE2 causes smooth muscle contraction and increased intracellular Ca2+ levels; however, it is still unclear whether EP1 receptor is exclusively coupled to G(q/11), which leading to activation of phospholipase C and phosphatidylinositol hydrolysis. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


:

Pssm-ID: 320272 [Multi-domain]  Cd Length: 294  Bit Score: 335.21  E-value: 4.20e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890935  33 GASPALPIFSMTLGAVSNLLALALLAQAAGRLRRRRSAaTFLLFVASLLATDLAGHVIPGALVLRLYTAGRAPAGG---- 108
Cdd:cd15144     1 PASPAMPIFSMTLGALSNIVALVILAQSYARFRRRSKA-TFLLFASSLVLTDLAGHVIPGALVLRLYLSGQMPAEEprga 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890935 109 ACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTRPLLHAARVSVSRARLALAAVAAVALAVALLPLARVGRYELQYPGTWC 188
Cdd:cd15144    80 LCQFFGACMVFFGLCPLFLGCAMAVERCVGVTRPLLHSSVVTTTRTKLSLLAIWAVALAVALLPLFRFGRYKPQFPGTWC 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890935 189 FIGLGPSGGWRQALLAGLFAGLGLVALLAALVCNTLSGLALLrarwrrrsrgpppasgpdsRRRWGARGPrsasassass 268
Cdd:cd15144   160 FIKVQPPGSWADVAFALLFSLLGLASLLVSLVCNTISGLTLV-------------------RARLRKKCS---------- 210
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890935 269 iasastafggsqsrGSARRARSHDVEMVGQLVGIMVVSCICWSPMLVLVALAVGGWSS---TSLQRPLFLAVRLASWNQI 345
Cdd:cd15144   211 --------------CSNRRAKSHDIEMVVQLVGIMVVSCICWSPLLIFVLISVSRSYErpkHQYEKLLFLGVRLASWNQI 276
                         330
                  ....*....|....*...
gi 1622890935 346 LDPWVYILLRQAVLRQLL 363
Cdd:cd15144   277 LDPWVYILLRRAVLRKVL 294
 
Name Accession Description Interval E-value
7tmA_PGE2_EP1 cd15144
prostaglandin E2 receptor EP1 subtype, member of the class A family of seven-transmembrane G ...
33-363 4.20e-114

prostaglandin E2 receptor EP1 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP1, also called prostanoid EP1 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. It has been shown that stimulation of the EP1 receptor by PGE2 causes smooth muscle contraction and increased intracellular Ca2+ levels; however, it is still unclear whether EP1 receptor is exclusively coupled to G(q/11), which leading to activation of phospholipase C and phosphatidylinositol hydrolysis. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320272 [Multi-domain]  Cd Length: 294  Bit Score: 335.21  E-value: 4.20e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890935  33 GASPALPIFSMTLGAVSNLLALALLAQAAGRLRRRRSAaTFLLFVASLLATDLAGHVIPGALVLRLYTAGRAPAGG---- 108
Cdd:cd15144     1 PASPAMPIFSMTLGALSNIVALVILAQSYARFRRRSKA-TFLLFASSLVLTDLAGHVIPGALVLRLYLSGQMPAEEprga 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890935 109 ACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTRPLLHAARVSVSRARLALAAVAAVALAVALLPLARVGRYELQYPGTWC 188
Cdd:cd15144    80 LCQFFGACMVFFGLCPLFLGCAMAVERCVGVTRPLLHSSVVTTTRTKLSLLAIWAVALAVALLPLFRFGRYKPQFPGTWC 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890935 189 FIGLGPSGGWRQALLAGLFAGLGLVALLAALVCNTLSGLALLrarwrrrsrgpppasgpdsRRRWGARGPrsasassass 268
Cdd:cd15144   160 FIKVQPPGSWADVAFALLFSLLGLASLLVSLVCNTISGLTLV-------------------RARLRKKCS---------- 210
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890935 269 iasastafggsqsrGSARRARSHDVEMVGQLVGIMVVSCICWSPMLVLVALAVGGWSS---TSLQRPLFLAVRLASWNQI 345
Cdd:cd15144   211 --------------CSNRRAKSHDIEMVVQLVGIMVVSCICWSPLLIFVLISVSRSYErpkHQYEKLLFLGVRLASWNQI 276
                         330
                  ....*....|....*...
gi 1622890935 346 LDPWVYILLRQAVLRQLL 363
Cdd:cd15144   277 LDPWVYILLRRAVLRKVL 294
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
280-351 2.74e-04

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 42.28  E-value: 2.74e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622890935 280 QSRGSARRARSHDVEMVGQLVGIMVVsciCWSPMLVLVALAVGGW---SSTSLQRPLFLAVRLASWNQILDPWVY 351
Cdd:pfam00001 185 QKSSERTQRRRKALKTLAVVVVVFIL---CWLPYHIVNLLDSLALdceLSRLLDKALSVTLWLAYVNSCLNPIIY 256
 
Name Accession Description Interval E-value
7tmA_PGE2_EP1 cd15144
prostaglandin E2 receptor EP1 subtype, member of the class A family of seven-transmembrane G ...
33-363 4.20e-114

prostaglandin E2 receptor EP1 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP1, also called prostanoid EP1 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. It has been shown that stimulation of the EP1 receptor by PGE2 causes smooth muscle contraction and increased intracellular Ca2+ levels; however, it is still unclear whether EP1 receptor is exclusively coupled to G(q/11), which leading to activation of phospholipase C and phosphatidylinositol hydrolysis. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320272 [Multi-domain]  Cd Length: 294  Bit Score: 335.21  E-value: 4.20e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890935  33 GASPALPIFSMTLGAVSNLLALALLAQAAGRLRRRRSAaTFLLFVASLLATDLAGHVIPGALVLRLYTAGRAPAGG---- 108
Cdd:cd15144     1 PASPAMPIFSMTLGALSNIVALVILAQSYARFRRRSKA-TFLLFASSLVLTDLAGHVIPGALVLRLYLSGQMPAEEprga 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890935 109 ACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTRPLLHAARVSVSRARLALAAVAAVALAVALLPLARVGRYELQYPGTWC 188
Cdd:cd15144    80 LCQFFGACMVFFGLCPLFLGCAMAVERCVGVTRPLLHSSVVTTTRTKLSLLAIWAVALAVALLPLFRFGRYKPQFPGTWC 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890935 189 FIGLGPSGGWRQALLAGLFAGLGLVALLAALVCNTLSGLALLrarwrrrsrgpppasgpdsRRRWGARGPrsasassass 268
Cdd:cd15144   160 FIKVQPPGSWADVAFALLFSLLGLASLLVSLVCNTISGLTLV-------------------RARLRKKCS---------- 210
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890935 269 iasastafggsqsrGSARRARSHDVEMVGQLVGIMVVSCICWSPMLVLVALAVGGWSS---TSLQRPLFLAVRLASWNQI 345
Cdd:cd15144   211 --------------CSNRRAKSHDIEMVVQLVGIMVVSCICWSPLLIFVLISVSRSYErpkHQYEKLLFLGVRLASWNQI 276
                         330
                  ....*....|....*...
gi 1622890935 346 LDPWVYILLRQAVLRQLL 363
Cdd:cd15144   277 LDPWVYILLRRAVLRKVL 294
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
33-362 2.84e-71

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 225.20  E-value: 2.84e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890935  33 GASPALPIFSMTLGAVSNLLALALLAqaagRLRRRRSAATFLLFVASLLATDLAGHVIPGALVLRLYTAGRAPAGG--AC 110
Cdd:cd14981     1 GESPAPPALMFVFGVLGNLLALIVLA----RSSKSHKWSVFYRLVAGLAITDLLGILLTSPVVLAVYASNFEWDGGqpLC 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890935 111 HFLGGCMVFFGLCPLLLGCGMAVERCVGVTRPLLHAARVSVSRARLALAAVAAVALAVALLPLARVGRYELQYPGTWCFI 190
Cdd:cd14981    77 DYFGFMMSFFGLSSLLIVCAMAVERFLAITHPFFYNSHVKKRRARLMLGAVWAFALLIASLPLLGLGSYVLQYPGTWCFL 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890935 191 GLGpSGGWRQALLAGLFAGLGLVALLAALVCNTLSGLALlrarwrrrsrgpppasgpdSRRRWGARGPRSasassassia 270
Cdd:cd14981   157 DFY-SKNTGDAAYAYLYSILGLLILLVTLLCNLLVIITL-------------------LRMRRRKKRHRR---------- 206
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890935 271 sastafggsqSRGSARRARSHDVEMVGQLVGIMVVSCICWSPMLVLVALAVGGWSSTSlQRPLFLAVRLASWNQILDPWV 350
Cdd:cd14981   207 ----------SRRSARRQKRNEIQMVVLLLAITVVFSVCWLPLMIRVLINATGDSEKN-GKTDLLAVRMASWNQILDPWV 275
                         330
                  ....*....|..
gi 1622890935 351 YILLRQAVLRQL 362
Cdd:cd14981   276 YILLRKEVLRRL 287
7tmA_FP cd15145
prostaglandin F2-alpha receptor, member of the class A family of seven-transmembrane G ...
40-362 3.69e-54

prostaglandin F2-alpha receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The PGF2-alpha receptor, also called prostanoid FP receptor, is a class A G-protein coupled receptor whose endogenous ligand is prostaglandin F2-alpha. PGF2-alpha binding to this receptor is coupled to the stimulation of phospholipase C (PLC) pathway via G-protein subunit G(q). This leads to the release of inositol trisphosphate (IP3) and diacylglycerol (DAG) which results in increased intracellular Ca2+ levels and activation of PKC. The receptor activation primarily induces uterine contraction and bronchoconstriction, and stimulates luteolysis. Like most prostanoid receptors, the PGF2-alpha receptor has also been implicated in tumor angiogenesis and metastasis.


Pssm-ID: 320273 [Multi-domain]  Cd Length: 290  Bit Score: 181.17  E-value: 3.69e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890935  40 IFSMTLGAVSNLLALALLAQAAGRLRRRrSAATFLLFVASLLATDLAGHVIPGALVLRLYTAGRA-----PAGGACHFLG 114
Cdd:cd15145     8 IIFMTVGILSNSLAIAILMKAYQRFRQK-SKASFLLLASGLVITDFFGHLINGTIAVFVYASDKDwirfdQSNILCSVFG 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890935 115 GCMVFFGLCPLLLGCGMAVERCVGVTRPLLHAARVSVSRARLALAAVAAVALAVALLPLARVGRYELQYPGTWCFIGLGP 194
Cdd:cd15145    87 ICMVFFGLCPLLLGSVMAVERCIGVTKPIFHSTKMTSKHVKMMLSGVCLFAVLVALLPILGHRDYQIQASRTWCFYKTEH 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890935 195 SGGWRQALLAGLFAGLGLVALLAALVCNTLSGLALLRarwrrrsrgpppasgpdSRRRwgargprsasassassiasast 274
Cdd:cd15145   167 IEDWEDRFYLLLFSFLGLLALAISFLCNAITGITLLR-----------------VKFR---------------------- 207
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890935 275 afggSQSRgsaRRARSHDVEMVGQLVGIMVVSCICWSPMLVLVALAV--GGWSSTSLQRPLFlAVRLASWNQILDPWVYI 352
Cdd:cd15145   208 ----SQQH---RQGRSHHFEMVIQLLAIMCVSCICWSPFLVTMANIGinGRDSLESCETILF-ALRMATWNQILDPWVYI 279
                         330
                  ....*....|
gi 1622890935 353 LLRQAVLRQL 362
Cdd:cd15145   280 LLRKAVLKNL 289
7tmA_TXA2_R cd15143
thromboxane A2 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
66-362 3.88e-42

thromboxane A2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The thromboxane receptor, also known as the prostanoid TP receptor, is a class A G-protein coupled receptor whose endogenous ligand is thromboxane A2 (TXA2). TXA2 is the major product of cyclooxygenase metabolite of arachidonic acid that found predominantly in platelets and stimulates platelet aggregation, Ca2+ influx into platelets, and also causes vasoconstriction. TXA2 has been shown to be involved in immune regulation, angiogenesis and metastasis, among many others. Activation of TXA2 receptor is coupled to G(q) and G(13), resulting in the activations of phospholipase C and RhoGEF, respectively. TXA2 receptor is widely distributed in the body and is abundantly expressed in thymus and spleen.


Pssm-ID: 320271 [Multi-domain]  Cd Length: 296  Bit Score: 149.97  E-value: 3.88e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890935  66 RRRSAATFLLFVASLLATDLAGHVIPGALVLRLYTAGRA-----PAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVT 140
Cdd:cd15143    33 KSRSRSSFLIFLCGLVVTDFLGLLVTGTIVISFHLTNFNwrvvdPDCYLCNFMGLSMVFYGLCPLLLGATMAVERFFGIN 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890935 141 RPLLHAARVSVSRARLALAAVAAVALAVALLPLARVGRYELQYPGTWCFIGLGPSGGwrQALLAGLFAGLGLVALLAALV 220
Cdd:cd15143   113 RPFSRSTAMSKRRAWYMVGMVWAFAFLLGLLPILGLGRYTLQYPGSWCFLTLLFDSK--DVAFGLLFSFLGILSVGLSFL 190
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890935 221 CNTLSGLALLRARwrrrsrgpppasgpdsrrrwgargprsasassassiasastafggsQSRGSARRARSHDVEMVGQLV 300
Cdd:cd15143   191 LNTVSVVTLCRVY----------------------------------------------HDRESVQRRRDSEVEMMVQLL 224
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622890935 301 GIMVVSCICWSPMLVLVALAV---------GGWSSTSLQRPLFLAVRLASWNQILDPWVYILLRQAVLRQL 362
Cdd:cd15143   225 GIMVIASVCWLPLLVFIAQTVlqkppamllAGQIPRLTEKKLLIYLRFATWNQILDPWVYILFRRAVLKRL 295
7tmA_PGE2_EP3 cd15146
prostaglandin E2 receptor EP3 subtype, member of the class A family of seven-transmembrane G ...
35-361 5.03e-31

prostaglandin E2 receptor EP3 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP3, also called prostanoid EP3 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. Stimulation of the EP3 receptor by PGE2 preferentially couples to G(i) protein. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels, which subsequently produces smooth muscle contraction. Knockout mice studies suggest that the EP3 receptor may act as a systemic vasopressor. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320274 [Multi-domain]  Cd Length: 308  Bit Score: 120.37  E-value: 5.03e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890935  35 SPALPIFSMTLGAVSNLLALALLAQAAgRLRRRRSAATFLLFVASLLATDLAGHVIPGALVLRLYTAGRA-----PAGGA 109
Cdd:cd15146     3 SVAFPITMMITGMVGNALAMLLVYRSY-RKKENKRKRSFLLCIGSLALTDLFGQLLTSPIVISVYLSDRKwervdPSGRL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890935 110 CHFLGGCMVFFGLCPLLLGCGMAVERCVGVTRPLLHAARVSVSRARLALAAVAAVALAVALLPLARVGRYELQYPGTWCF 189
Cdd:cd15146    82 CPFFGLCMTVFGLCPLFIASAMAIERALAIRAPHWYSSHMKTRVTKAVLLGIWLAVLAFALLPIAGVGQYTLQWPGTWCF 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890935 190 IGLGpSGGWRQALLAGLFAGLGLVALLAALVCNTLSglallrarwrrrsrgpppASGPDSRRRWGArgprsasassassi 269
Cdd:cd15146   162 ISTG-DGEPGNNFFASTFASLGLFSLCVTFSCNLAT------------------IRALVSRCKTKA-------------- 208
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890935 270 asastafggSQSRGSARRARShDVEMVGQLVGIMVVSCICWSPMLVLV-------------ALAVGGWSSTSLQRP--LF 334
Cdd:cd15146   209 ---------GASVSSKQWERI-TTETLIQLLGIMCVLSACWSPLLVLMlkmisnhtssehcKSATAPPQSTELQKDcnFF 278
                         330       340
                  ....*....|....*....|....*...
gi 1622890935 335 L-AVRLASWNQILDPWVYILLRQAVLRQ 361
Cdd:cd15146   279 LtAVRLASLNQILDPWVYLLLRKILLRK 306
7tmA_PGE2_EP4 cd15142
prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G ...
33-363 6.93e-25

prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP4, also called prostanoid EP4 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. Like the EP2 receptor, stimulation of the EP4 receptor by PGE2 causes cAMP accumulation through G(s) protein activation. Knockout studies in mice suggest that EP4 receptor may be involved in the maintenance of bone mass and fracture healing. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320270 [Multi-domain]  Cd Length: 302  Bit Score: 103.35  E-value: 6.93e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890935  33 GASPALPIFSMTLGAVSNLLALALLAQAagrlRRRRSAATFLLFVASLLATDLAGHVIPGALVLRLYTAGRAPAGGA-CH 111
Cdd:cd15142     1 ATPPTIPAVMFIFGVVGNLIAIVVLCKS----RKEQKETTFYTLVCGLAVTDLLGTCLASPVTIATYLKGRWPGGQPlCE 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890935 112 FLGGCMVFFGLCPLLLGCGMAVERCVGVTRPLLHAARVSVSRARLALAAVAAVALAVALLPLARVGRYELQYPGTWCFIG 191
Cdd:cd15142    77 YFSFILLFFSLSGLSIICAMSIERYLAINHAYFYNHYVDKRLAGLTLFAIYASNILFCALPSMGLGKSKLQYPKTWCFID 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890935 192 lgpsggWRQALLAG-----LFAGLGLVALLAALVCNTLSGLALLRARWRRRSRgppPASGPDSRrrwgargprsasassa 266
Cdd:cd15142   157 ------WRTNVSVHaaysyMYAGFSSLLILVTVLCNVLVCGALIRMHRQFVRR---TSLGTDQR---------------- 211
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890935 267 ssiasastaFGGSQSRGSARRARSHDVEMVGQLVGIMVVSCICWSPMLVLV---ALAVGGWSSTSLQRPLFLAVRLASWN 343
Cdd:cd15142   212 ---------LSDFRRRRSFRRMAGAEIQMVILLIATSVVVLICSIPLVVRVfvnQLYQPAVEKDLDKNPDLQAIRIASVN 282
                         330       340
                  ....*....|....*....|
gi 1622890935 344 QILDPWVYILLRQAVLRQLL 363
Cdd:cd15142   283 PILDPWIYILLRKTVLSKLI 302
7tmA_PGE2_EP2 cd15139
prostaglandin E2 receptor EP2 subtype, member of the class A family of seven-transmembrane G ...
33-362 6.64e-18

prostaglandin E2 receptor EP2 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP2, also called prostanoid EP2 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. Stimulation of the EP2 receptor by PGE2 causes cAMP accumulation through G(s) protein activation, which subsequently produces smooth muscle relaxation and mediates the systemic vasodepressor response to PGE2. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320267 [Multi-domain]  Cd Length: 299  Bit Score: 83.29  E-value: 6.64e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890935  33 GASPALPIFSMTLGAVSNLLALALLAQAAgRLRRRRSAATFLLFVASLLATDLAGHVIPGALVLRLYTA-----GRAPAG 107
Cdd:cd15139     1 GGSPAISALMFSAGVLGNVLALVLLERRR-RKEVGRRQSLFHVLVTSLVITDLLGTCLISPVVLASYSRnttlvGMSPNR 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890935 108 GACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTRPLLHAARVSVSRARLALAAVAAVALAVALLPLARVGRYeLQY-PGT 186
Cdd:cd15139    80 LVCGYFGFAMTFFSLATMLILLAMALERCLSIGHPYFYERYVSKRCGYVTIPLIYLLCALFCLFPFLGFGKY-VQYcPGT 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890935 187 WCFIGLGPSGGWRQALlAGLFAGLGLVALLAALVCNTLSGLALLRArwrrrsrgpppasgpdsRRRWGARGPRSasassa 266
Cdd:cd15139   159 WCFIDMNPEASEHRAY-ANLYATLLLLLIVAVVLCNASVIYHLVRM-----------------YRRRKRNRSSV------ 214
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890935 267 ssiasastafGGSQSRGSARRARSHDVEMVGQLVGIMVVSCICWSPMLVLVALAVGGWSSTslQRPLFLAVRLASWNQIL 346
Cdd:cd15139   215 ----------GGRARSHRRRFSMAEEVEHLILLVFMTIIFVICSLPLTIQVYMNTFSDSEN--HKWDLIALRFLSVNPII 282
                         330
                  ....*....|....*.
gi 1622890935 347 DPWVYILLRQAVLRQL 362
Cdd:cd15139   283 DPWVFIILSPPVLRLL 298
7tmA_PGI2 cd15141
prostaglandin I2 receptor, member of the class A family of seven-transmembrane G ...
63-362 2.24e-14

prostaglandin I2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin I2 receptor (also called prostacyclin receptor or prostanoid IP receptor) is a class A, G protein-coupled receptor whose endogenous ligand is prostacyclin, which is the major product of cyclooxygenase metabolite of arachidonic acid that found predominantly in platelets and vascular smooth muscle cells (VSMCs). The PGI2 receptor is coupled to both G(s) and G(q) protein subtypes, resulting in increased cAMP formation, phosphoinositide turnover, and Ca2+ signaling. PGI2 receptor activation by prostacyclin induces VSMC differentiation and produces a potent vasodilation and inhibition of platelet aggregation.


Pssm-ID: 320269 [Multi-domain]  Cd Length: 301  Bit Score: 73.32  E-value: 2.24e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890935  63 RLRRRRSAATFLLFVASLLATDLAGHVIPGALVLRLYT-----AGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCV 137
Cdd:cd15141    29 RKERRTKSSAFCVLVTGLAATDLLGTCFLSPMVFVSYAqnsslLGLAAGQPLCHLFAFAMTFFGLASMLILFAMAVERCL 108
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890935 138 GVTRPLLHAARVSVSRARLALAAVAAVALAVALLPLARVGRYELQYPGTWCFIGLGPSGGWRQALLAG--LFAGLGLVAL 215
Cdd:cd15141   109 AISHPYFYAQHSGRRLAKLALPAIYAFGALFCALPLLGVGRHKQYCPGTWCFIRMTVPGHREPGSLAFslLYASLMALLI 188
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890935 216 LAALVCNtlsglallrarwrrrsrGPPPASGPDSRRRWGARgprsasassassiasaSTAFGGSQSRGSARRARSHDVEM 295
Cdd:cd15141   189 AAIFLCN-----------------GSVTVSLCRMYRGQKAR----------------RGSLRRCGRLGWWLGQGEEEVDH 235
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622890935 296 VGQLVGIMVVSCICWSPMLVLVALavGGWSSTSLQRPLFLAVRLASWNQILDPWVYILLRQAVLRQL 362
Cdd:cd15141   236 LILLALMTVIFVVCSLPLTIRAFL--GAIAPDGNESGDLLAFRFSAFNPILDPWIFIIFRKAVFRKL 300
7tmA_PGD2 cd15140
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
67-363 1.02e-06

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor (also called prostanoid DP receptor, DP1, or PGD2R1) is a G-protein coupled receptor whose endogenous ligand is prostaglandin D2 (PGD2). PGD2, the major cyclooxygenase metabolite of arachidonic acid produced by mast cells, mediates inflammatory reactions in response to allergen challenge and causes peripheral vasodilation. PGD2 exerts its biological effects by binding to two types of cell surface receptors: a DP1 receptor that belongs to the prostanoid receptor family and a chemoattractant receptor-homologous molecule expressed on the T-helper type 2 cells (CRTH2 or PD2R2).


Pssm-ID: 320268 [Multi-domain]  Cd Length: 312  Bit Score: 49.89  E-value: 1.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890935  67 RRSAATFLLFVASLLATDLAGHVIPGALVLRLYTAGR-----APAGGA--CHFLGGCMVFFGLCPLLLGCGMAVERCVGV 139
Cdd:cd15140    39 RPRTSVFYVLVTVLTVTDLLGKCLLSPVVLAAYAQNRslvglTPAGNLnlCQVFAFLMIFFGLASTFILLAMALECWLSL 118
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890935 140 TRPLLHAARVSVSRARLALAAVAAVALAVALLPLARVGRYELQYPGTWCFIGLGPSGGWRQALL-AGLFAGLGLVALLAA 218
Cdd:cd15140   119 GHPFFYQRHINKRLGALVSLILYAFCLGFCALPFFGFGRYVQYCPGTWCFIQMTAEESSTSALAySVLYGSLMGLLVLAI 198
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890935 219 LVCNTLSGLALLRARWRRRSRGPPpasgpdSRRRWGARGPrsasassassiasastafggsqsrgsARRARSHDVEMVGQ 298
Cdd:cd15140   199 VLCNLGIMRNLYQMYRRENEKGIP------STDLQGAAAF--------------------------PRQQEPAGMEELEH 246
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622890935 299 LV--GIM-VVSCICWSPmlVLVALAVGGWSSTSLQRPLFLAVRLASWNQILDPWVYILLRQAVLRQLL 363
Cdd:cd15140   247 LIllALMtVLFTACSLP--VIARAYVGAFKGEKNEAADLTALRFLSVNSIVDPWIFIIFRTSKFRGFL 312
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
280-351 2.74e-04

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 42.28  E-value: 2.74e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622890935 280 QSRGSARRARSHDVEMVGQLVGIMVVsciCWSPMLVLVALAVGGW---SSTSLQRPLFLAVRLASWNQILDPWVY 351
Cdd:pfam00001 185 QKSSERTQRRRKALKTLAVVVVVFIL---CWLPYHIVNLLDSLALdceLSRLLDKALSVTLWLAYVNSCLNPIIY 256
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
65-150 2.01e-03

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 39.58  E-value: 2.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890935  65 RRRRSaaTFLLFVASLLATDL--AGHVIPgaLVLRLYTAGRAPAGGA-CHFLGGCMVFFGLCPLLLGCGMAVERCVGVTR 141
Cdd:cd00637    27 RRLRT--VTNYFILNLAVADLlvGLLVIP--FSLVSLLLGRWWFGDAlCKLLGFLQSVSLLASILTLTAISVDRYLAIVH 102

                  ....*....
gi 1622890935 142 PLLHAARVS 150
Cdd:cd00637   103 PLRYRRRFT 111
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
65-151 7.26e-03

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 38.05  E-value: 7.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890935  65 RRRRSAATFllFVASLLATDLAGHV--IPGALVlRLYTAGRAPAG-GACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTR 141
Cdd:pfam00001  13 KKLRTPTNI--FLLNLAVADLLFSLltLPFWLV-YYLNHGDWPFGsALCKIVGALFVVNGYASILLLTAISIDRYLAIVH 89
                          90
                  ....*....|
gi 1622890935 142 PLLHAARVSV 151
Cdd:pfam00001  90 PLRYKRRRTP 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH